101 results on '"Polymyositis-Dermatomyositis"'
Search Results
2. Thymus variants on imaging of patients with primary Sjögren's syndrome and polymyositis/dermatomyositis: clinical and immunological significance.
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Murata, Okinori, Suzuki, Katsuya, and Takeuchi, Tsutomu
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SJOGREN'S syndrome ,DERMATOMYOSITIS ,POLYMYOSITIS ,MYOSITIS ,THYMUS ,RHEUMATOID factor ,COMPUTED tomography - Abstract
We investigated the presence of radiographic thymus variants using a scoring system and examined their association with clinical and immunological features in primary Sjögren's syndrome (pSS) and polymyositis/dermatomyositis (PM/DM) patients. Cases of 72 patients with pSS and 47 with PM/DM were randomly selected from all visitors to our department who received chest CT scanning, excluding those with thymoma or thymic cyst, or age <30 years. We quantitatively interpreted and assessed thymus size and attenuation score in axial CT images. Thymic enlargement was identified in 16 (22.2%) pSS and 14 (29.8%) PM/DM patients. A thymus attenuation score ≥ 2 was seen in 11 (15.3%) pSS and 9 (19.1%) PM/DM patients. Thymic enlargement showed a significant association with the titre of rheumatoid factor in PM/DM patients. Thymic enlargement and score showed a significant association with body weight in pSS patients. Radiographic thymus variants are often observed in pSS and PM/DM patients, particularly in cases of PM/DM, and may suggest the role of an abnormal immune response in their pathogenesis. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Risk Prediction Modeling Based on a Combination of Initial Serum Biomarker Levels in Polymyositis/Dermatomyositis–Associated Interstitial Lung Disease
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Takahisa, Gono, Kenichi, Masui, Naoshi, Nishina, Yasushi, Kawaguchi, Atsushi, Kawakami, Kei, Ikeda, Yohei, Kirino, Yumiko, Sugiyama, Yoshinori, Tanino, Takahiro, Nunokawa, Yuko, Kaneko, Shinji, Sato, Katsuaki, Asakawa, Taro, Ukichi, Shinjiro, Kaieda, Taio, Naniwa, Yutaka, Okano, Masataka, Kuwana, and Yoshie, Kawahara
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Immunology ,Risk Assessment ,Polymyositis ,Dermatomyositis ,Rheumatology ,Serum biomarkers ,Internal medicine ,Risk of mortality ,Humans ,Immunology and Allergy ,Medicine ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Proportional hazards model ,Mucin-1 ,Interstitial lung disease ,Retrospective cohort study ,Middle Aged ,Models, Theoretical ,Prognosis ,medicine.disease ,Polymyositis-Dermatomyositis ,C-Reactive Protein ,Female ,Lung Diseases, Interstitial ,Risk assessment ,business ,Biomarkers - Abstract
OBJECTIVE To establish predictive models for mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD) using a combination of initial serum biomarker levels. METHODS The Multicenter Retrospective Cohort of Japanese Patients with Myositis-Associated ILD (JAMI) database of 497 incident cases of PM/DM-ILD was used as a derivation cohort, and 111 cases were additionally collected as a validation cohort. Risk factors predictive of all-cause mortality were identified by univariate and multivariable Cox regression analyses using candidate serum biomarkers as explanatory variables. The predictive models for mortality were generated in patients with and those without anti-melanoma differentiation-associated gene 5 (MDA-5) antibody, using a combination of risk factors. Cumulative survival rates were assessed using Kaplan-Meier analysis, and were compared between subgroups using the Breslow test. RESULTS In the derivation cohort, C-reactive protein (CRP) and Krebs von den Lungen 6 (KL-6) levels were identified as independent risk factors for mortality in both anti-MDA-5-positive and anti-MDA-5-negative patients. We then developed a prediction model based on anti-MDA-5 antibody status, CRP level, and KL-6 level, termed the "MCK model," to identify patients at low (
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- 2021
4. 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes
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Katsuya Mitamura, R. Wakiya, Hiroaki Dobashi, Yuka Yamamoto, Yasukage Takami, Yoshihiro Nishiyama, Takashi Norikane, Kengo Fujimoto, Shusaku Nakashima, and Hanae Arai-Okuda
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,lcsh:R895-920 ,Biophysics ,030204 cardiovascular system & hematology ,Polymyositis ,Gastroenterology ,Dermatomyositis ,030218 nuclear medicine & medical imaging ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Computer Science (miscellaneous) ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,chemistry.chemical_classification ,biology ,business.industry ,Skeletal muscle ,medicine.disease ,18F-FDG ,Polymyositis-Dermatomyositis ,Enzyme ,medicine.anatomical_structure ,PET ,chemistry ,biology.protein ,Molecular Medicine ,Creatine kinase ,Original Article ,business - Abstract
Background Muscle enzymes are the major noninvasive diagnostic parameters useful in polymyositis/dermatomyositis (PM/DM). Few studies have yet correlated findings on 18F-FDG PET with disease activity in patients with PM/DM. Purpose We evaluated 18F-FDG muscle uptake in patients with PM/DM compared with non-muscular diseases and correlated the results with serum muscle enzymes. Methods A total of 28 patients with untreated PM/DM and 28 control patients with non-muscular diseases were examined with 18F-FDG PET/CT. 18F-FDG uptake was evaluated in 9 proximal skeletal muscle regions bilaterally. The uptake was scored as follows: 0 = less than that of the mediastinal blood vessels, 1 = greater than or equal to that of the mediastinal blood vessels, and 2 = greater than or equal to that of the liver. A score 1 or 2 was considered positive. The mean and maximum standardized uptake values (SUV) were calculated in each muscle and were averaged for all muscle regions. PET findings were correlated with serum muscle enzymes. Results 18F-FDG uptake was observed in 82% of patients with PM/DM and 7% of control patients. The number of positive regions, total score, mean SUVmean, and mean SUVmax in patients with PM/DM were significantly higher than those in the control patients (all P < 0.001). The total score of 2 was the best cut-off value that could discriminate patients with PM/DM from control patients. The total score, mean SUVmean, and mean SUVmax showed significant correlations with creatine kinase (P = 0.047, 0.002, 0.010, respectively) and aldolase (P = 0.036, 0.005, 0.038, respectively). Conclusion 18F-FDG PET/CT using visual and SUV methods demonstrated its usefulness by discriminating PM/DM from non-muscular diseases and correlating with serum muscle enzymes in patients with PM/DM.
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- 2020
5. Clinical and Serological Features and Pregnancy Outcomes in Women with Polymyositis/Dermatomyositis: A Case-based Review
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Ayako Nakajima, Kentaro Noda, Yuhei Ito, Yasuo Suzuki, and Yoshiki Yamamoto
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Dermatomyositis ,Serology ,Pregnancy ,Internal Medicine ,medicine ,Humans ,Caesarean section ,Myositis ,Autoantibodies ,business.industry ,Cesarean Section ,Infant, Newborn ,Pregnancy Outcome ,General Medicine ,medicine.disease ,Tacrolimus ,Polymyositis-Dermatomyositis ,Prednisolone ,Female ,business ,medicine.drug - Abstract
We encountered a 30-year-old woman who developed dermatomyositis during pregnancy and was positive for anti-Mi-2 antibodies. She was successfully treated with prednisolone and tacrolimus and delivered a healthy child. We reviewed the cases of idiopathic inflammatory myositis (IIM) that developed during pregnancy that were published after the year 2000 to elucidate the profile of myositis-specific antibodies (MSAs) in them and to evaluate their obstetric outcomes. In cases with IIM that developed during pregnancy, anti-Mi-2, anti-TIF1-g, anti-Jo-1, and anti-EJ antibodies was detected in one case each. The obstetric outcomes of the IIM-complicated pregnancies were poor, especially when complicated with active maternal myositis. Further studies focusing on the possible causal relationships between MSAs and cases with IIM that developed during pregnancy are needed. For better obstetric outcomes, appropriate suppression of the maternal disease activity using immunosuppressants and vigilance regarding the patient's requirement of Caesarean section is important.
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- 2021
6. miR-1 is a novel biomarker for polymyositis/dermatomyositis-associated interstitial lung disease
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D. Kishimoto, Ryusuke Yoshimi, Reikou Kamiyama, Hideaki Nakajima, Mitsuhiro Takeno, Yumiko Sugiyama, Shigeru Ohno, Yohei Kirino, and Yosuke Kunishita
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Adult ,Male ,medicine.medical_specialty ,macromolecular substances ,Gastroenterology ,Polymyositis ,Dermatomyositis ,Disease activity ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Aged ,030203 arthritis & rheumatology ,Immunosuppressive treatment ,business.industry ,Interstitial lung disease ,Middle Aged ,medicine.disease ,MicroRNAs ,Polymyositis-Dermatomyositis ,Biomarker (medicine) ,Female ,Lung Diseases, Interstitial ,business ,Biomarkers - Abstract
Objectives: Although intensive immunosuppressive treatment is necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/D...
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- 2019
7. Exploration of pathomechanism using comprehensive analysis of serum cytokines in polymyositis/dermatomyositis-interstitial lung disease
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Shogo Matsuda, Shigeki Arawaka, Takayasu Suzuka, Tohru Takeuchi, Yuri Ito, Kentaro Isoda, Shigeki Makino, Takaaki Ishida, Youhei Fujiki, Koji Nagai, Keisuke Fukui, Kenichiro Hata, Takeshi Shoda, and Takuya Kotani
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Male ,0301 basic medicine ,Cytokine profile ,medicine.medical_treatment ,Polymyositis ,Dermatomyositis ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,medicine ,Cluster Analysis ,Humans ,Pharmacology (medical) ,Aged ,Retrospective Studies ,030203 arthritis & rheumatology ,Principal Component Analysis ,biology ,business.industry ,Interstitial lung disease ,Middle Aged ,Prognosis ,medicine.disease ,Serum cytokine ,Polymyositis-Dermatomyositis ,030104 developmental biology ,Cytokine ,Immunology ,biology.protein ,Cytokines ,Female ,Antibody ,Lung Diseases, Interstitial ,business ,Biomarkers - Abstract
Objectives To elucidate the serum cytokine profile and address the pathomechanism of interstitial lung disease (ILD) complicated with PM/DM. Methods Forty patients with PM/DM-ILD were enrolled, and principal components analysis and cluster analysis were performed to classify patients into subgroups. Additionally, we compared cytokine profiles between the survivors and dead patients and between anti-melanoma differentiation-associated gene 5 antibody- and anti-aminoacyl tRNA synthetase antibody-positive ILD patients. We also examined the association of various cytokines with disease activity indicators and prognosis of ILD. Results The principal components analysis data allowed classification of the cytokine profile into three groups: group 1, neutrophilic and M1-macrophage-driven cytokines; group 2, type 1 Th cell-driven and M2-macrophage-induced cytokines; and group 3, M2-macrophage-driven cytokines. Cluster analysis showed the presence of PM/DM-ILD patient groups with high or low levels of total cytokines. Ninety percent of patients who died of ILD were included in clusters with high cytokine levels. Serum cytokine levels of all groups were significantly higher in the anti-melanoma differentiation-associated gene 5 antibody-positive patients than in the anti-aminoacyl tRNA synthetase antibody-positive patients. Groups 1 and 2 significantly correlated with known factors for poor prognosis, such as serum ferritin levels and alveolar-arterial oxygen difference. Serum cytokine levels of patients in group 1 were significantly higher initially and at 2 and 4 weeks in those who died. Conclusion These findings suggested that the activation of monocytes, macrophages and type 1 Th cells, and neutrophils play roles in the pathomechanism of PM/DM-ILD, and group 1 cytokines could be useful biomarkers for predicting prognosis of PM/DM-ILD.
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- 2019
8. KL-6 is a long-term disease-activity biomarker for interstitial lung disease associated with polymyositis/dermatomyositis, but is not a short-term disease-activity biomarker
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Hisashi Yamanaka, Yasuhiro Katsumata, Hidenaga Kawasumi, Yasushi Kawaguchi, and Masanori Hanaoka
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Adult ,Male ,medicine.medical_specialty ,Gastroenterology ,Polymyositis ,Dermatomyositis ,Disease activity ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Aged ,030203 arthritis & rheumatology ,business.industry ,Mucin-1 ,Interstitial lung disease ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,Polymyositis-Dermatomyositis ,Biomarker (medicine) ,Female ,Lung Diseases, Interstitial ,business ,Biomarkers - Abstract
Objectives: We aimed to evaluate the usefulness of serum KL-6 for interstitial lung disease (ILD) with polymyositis/dermatomyositis (PM/DM).Methods: All consecutive and previously untreated adult p...
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- 2019
9. Cutaneous Tuberculosis Presenting as Polymyositis-Dermatomyositis Complex
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Kavita Poonia, Surbhi Jain, and Gurvinder P. Thami
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Polymyositis-Dermatomyositis ,medicine.medical_specialty ,Cutaneous tuberculosis ,Rheumatology ,business.industry ,Medicine ,Humans ,Tuberculosis ,business ,Dermatology ,Dermatomyositis ,Polymyositis - Published
- 2020
10. Comparison of Clinical Features and Prognostic Factors of Polymyositis/Dermatomyositis Associated Interstitial Lung Disease According to Autoantibodies: Anti-Aminoacyl tRNA Synthetase Antibodies Versus Anti-Melanoma Differentiation-Associated Gene 5 Antibody
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Hui Li, Miaomiao Xie, Mei Huang, Yujuan Gao, Hourong Cai, Yan Li, Xin Yan, Jingjing Ding, Min Cao, and Jinghong Dai
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biology ,business.industry ,Aminoacyl tRNA synthetase ,Autoantibody ,Interstitial lung disease ,medicine.disease ,MELANOMA DIFFERENTIATION-ASSOCIATED GENE 5 ,Polymyositis-Dermatomyositis ,chemistry.chemical_compound ,chemistry ,medicine ,biology.protein ,Cancer research ,Antibody ,business - Abstract
Objective: The serum myositis-specific autoantibodies has been considered to be relatively specific and be useful for diagnosis of polymyositis/dermatomyositis associated interstitial lung disease (PM/DM-ILD). The goal of our retrospective study was to identify clinical features and prognostic factors for PM/DM-ILD based on serological phenotypes.Methods: PM/DM-ILD patients were diagnosed in the Department of Respiratory Medicine, Nanjing Drum Tower Hospital. MSAs were measured by anti-myositis antibody profile IgG detection kit. Based on the results of MSAs, the patients were divided into three groups: anti-MDA5 group, anti-Jo-1 group and other anti-ARS group. Kaplan-Meier, log rank, Kruskal-Wallis test and chi-square tests were used for analysis.Results: We identified 30 patients (22.0%) with positive anti-MDA5, 42 patients (31.0%) with positive anti-Jo-1 and 64 patients(47.0%) with other anti-ARS. acute disease onset was more frequently observed in the anti-MDA5 group (P = 0.005). The highest mortality rate was in the anti-MDA5 group (66.7%, P P P = 0.002), DAD pattern for HRCT imaging (P P = 0.02), presence of Anti-MDA5 (P P P = 0.02), and the treatment with PSL pulse and IVIG were markedly correlated with high mortality (P P = 0.001, respectively).Conclusion: Anti–MDA5 antibody is significantly associated with associated with worse prognosis in PM/DM-ILD patients. The application of PSL pulse and IVIG are not necessarily an effective treatment for positive anti-MDA5 patients.
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- 2020
11. Corticosteroids Treatment in Spinal Cord and Neuromuscular Disorders
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Sang Jun Na
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Pathology ,medicine.medical_specialty ,Neuromyelitis optica ,Chronic inflammatory demyelinating polyneuropathy ,business.industry ,medicine.disease ,Spinal cord ,lcsh:RC346-429 ,Myasthenia gravis ,Polymyositis-Dermatomyositis ,medicine.anatomical_structure ,medicine ,Acute spinal cord injury ,Corticosteroids ,Polymyositis/dermatomyositis ,business ,lcsh:Neurology. Diseases of the nervous system - Abstract
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of the vertebrates, as well as the synthetic analogs of these hormones that are synthesized in the laboratories. Two main classes of corticosteroids, glucocorticoids, and mineralocorticoids, are involved in a wide range of physiologic processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. Corticosteroids have been used for almost 60 years in medicine and their roles in patients have always been discussed by researchers and clinicians dedicated in the related field. Currently, they are still used in the treatment of patients with neurological disorders. Usually, corticosteroids are used in the treatment of various inflammatory diseases and conditions. In this review, we present five key indications, i.e., neuromyelitis optica, acute spinal cord injury, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, polymyositis/dermatomyositis for the systemic use of corticosteroids in neurology based on a mix of quality of evidence, prevalence, and impact on disease management.
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- 2017
12. AB0439 CAPILLAROSCOPIC PATTERNS IN PATIENTS WITH SYSTEMIC SCLEROSIS-POLYMYOSITIS/DERMATOMYOSITIS (SSc-PM/DM) OVERLAP SYNDROME
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O. Desinova, M. Starovoytova, and L. P. Ananyeva
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Plexus ,Pathology ,medicine.medical_specialty ,business.industry ,Immunology ,Overlap syndrome ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,Scleroderma ,Microcirculation ,Pathogenesis ,Polymyositis-Dermatomyositis ,Rheumatology ,Capillary sclerosis ,medicine ,Immunology and Allergy ,In patient ,business - Abstract
Background:Impaired microcirculation is one of the leading factors in local and general pathogenesis of SSc. Widefield nail-fold video-capillaroscopy (NFVC) stands as the most informative and at the same time simple method used for evaluation of capillary circulation.Objectives:To identify characteristic and specific for SSc– PM/DM capillaroscopic features.Methods:Both hand II – V fingers of 68 pts with SSc-PM/DM were subjected to widefield NFC, evaluated using a binocular 20x magnification Olympus microscope and analyzed in view of specific skin lesions discriminating diffuse and limited SSc forms.Results:SSc-specific dilatations of capillary loops were the most common for SSc-PM/DM and were found in all pts; 50% of them had signs of active scleroderma pattern, such as capillary loss or “avascular areas” (50%) and hemorrhages (51.5%), associated with generalized microvascular spasm in early disease and capillary sclerosis in advanced disease. The morphological capillary abnormalities such as varying degrees of capillary loops tortuosity/vascular inhomogeneity were present in 63% of examined nailfolds, branching bushy behavior of capillary loops and mega-capillaries predominated; architectural disorientation/disarrangement of capillary loops with formation of subcutaneous plexus was seen in more than 50% of them. Capillaroscopic changes consistent with active scleroderma pattern were present in 54 % and were associated with lab signs of inflammatory muscle syndrome and immunological disorders: giant capillaries (pConclusion:Thus, widefield NFVC revealed a “mixed” nature of capillaroscopic changes, combining features specific for SSc (capillary dilation, avascular areas, hemorrhages) and for PM/DM (bushy and giant capillaries, disorientation of capillary loops of the nailfold with formation of subcutaneous plexuses.)Disclosure of Interests:None declared
- Published
- 2021
13. Pulmonary hypertension in polymyositis-dermatomyositis: clinical and hemodynamic characteristics and response to vasoactive therapy.
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Minai, O. A.
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PULMONARY hypertension , *POLYMYOSITIS , *DERMATOMYOSITIS , *VASODILATORS - Abstract
The increased incidence of pulmonary hypertension and its association with decreased survival is well-recognised in patients with systemic sclerosis. This association is not widely appreciated in patients with polymyositis-dermatomyositis. We report clinical and hemodynamic characteristics and response to vasoactive therapy in three patients with polymyositis-dermatomyositis and pulmonary hypertension and discuss them in light of the available literature. [ABSTRACT FROM AUTHOR]
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- 2009
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14. Two distinct clinical types of interstitial lung disease associated with polymyositis-dermatomyositis.
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Won Huh, Jin, Soon Kim, Dong, Keun Lee, Chang, Yoo, Bin, Bum Seo, Joon, Kitaichi, Masanori, and Colby, Thomas V
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Summary: Most patients with interstitial lung disease (ILD) associated with collagen vascular diseases (CVD) have a chronic indolent course with a relatively favorable prognosis; however, acute progression has been reported in some polymyositis-dermatomyositis patients. This study evaluated the prevalence, clinical features, and outcome relative to the presentation type of ILD in polymyositis-dermatomyositis (PM–DM). Ninety-nine patients with newly diagnosed polymyositis-dermatomyositis seen at the Asan Medical Center in Korea between January 1990 and December 2004 were enrolled. The clinical, radiological, and pathological findings were retrospectively reviewed. ILD were divided into acute (dyspnea within 1 month before diagnosis) or chronic types. ILD was found on chest radiographs in 33 patients (33.3%), and 11 (33.3%) of these were considered acute. The acute group presented with more severe respiratory symptoms, hypoxemia, and poorer lung function. Patients with an acute presentation had ground glass opacity and consolidation on high-resolution computed tomography (HRCT), in contrast to reticulation and honeycombing in the chronic type. Surgical lung biopsy of one acute-type patient revealed diffuse alveolar damage, whereas biopsies in the chronic type showed usual interstitial pneumonia (UIP) in four cases and nonspecific interstitial pneumonia (NSIP) in another four. Eight acute-type patients (72.7%) died of respiratory failure within 1–2 months despite steroid therapy. The 3-year mortality rate of the chronic-type patients (21.2%) was not statistically significantly different from that of the patients without ILD (10.2%). In polymyositis-dermatomyositis, the acute, severe form of ILD was not infrequent. [Copyright &y& Elsevier]
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- 2007
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15. Anti-SS-A/Ro antibody positivity as a risk factor for relapse in patients with polymyositis/dermatomyositis
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Yoshia Miyawaki, Ken-Ei Sada, Sumie Hiramatsu, Haruki Watanabe, Yosuke Asano, Tomoko Kawabata, Keiji Ohashi, Michiko Morishita, Mariko Narazaki, Noriko Tatebe, Jun Wada, Katsue Watanabe, Eri Katsuyama, Takayuki Katsuyama, and Sonia Zeggar
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Adult ,Male ,medicine.medical_specialty ,genetic structures ,Disease ,Gastroenterology ,Polymyositis ,Dermatomyositis ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Recurrence ,Risk Factors ,Internal medicine ,medicine ,Humans ,In patient ,030212 general & internal medicine ,Risk factor ,Aged ,Retrospective Studies ,030203 arthritis & rheumatology ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Polymyositis-Dermatomyositis ,Antibodies, Antinuclear ,Immunology ,Female ,business ,Biomarkers ,Anti-SSA/Ro autoantibodies - Abstract
The objective of this study is to elucidate predictors of relapse in patients with polymyositis and dermatomyositis (PM/DM).Fifty PM/DM patients who achieved disease stabilization at Okayama University Hospital in 2004-2014 were enrolled retrospectively. Candidate predictors such as demographic factors, clinical symptoms, laboratory data, and treatment status were compared.The mean age of enrolled patients was 58 years; 34 were female. The patient groupings were as follows: 21 with PM, 27 with DM, and two with clinically amyopathic DM. During a mean observation period of 685 d, 5 patients (10%) died and 20 (40%) relapsed. The relapsed patients displayed baseline muscle weakness less frequently (85% versus 100%, p = .03) and anti-SS-A/Ro antibody more frequently (65% versus 27%, p = .007). Anti-SS-A/Ro-positive patients exhibited a higher relapse rate than anti-SS-A/Ro-negative patients (log-rank test, p = .03). Anti-SS-A/Ro-positive patients also exhibited higher anti-Jo-1 antibody positivity and lower levels of serum complement. After adjusting anti-Jo-1 antibody positivity, age, sex, CK500 IU/L, and lung involvement, anti-SS-A/Ro positivity was still an independent risk factor for higher relapse-rate (odds ratio, 5.5; 95% confidence interval, 1.4-25.1).Anti-SS-A/Ro antibody positivity may be a useful biomarker for prediction of relapse.
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- 2017
16. Association of anti-aminoacyl-transfer RNA synthetase antibody and anti-melanoma differentiation-associated gene 5 antibody with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease
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Naomi Yoshida, Tomohiro Ebata, Masataka Kuwana, Tomoaki Hoshino, Morihiro Tajiri, Daisuke Wakasugi, Hiroaki Ida, Masayuki Nakamura, Masaki Tominaga, Kiminori Fujimoto, Shinjiro Kaieda, Masaki Okamoto, Tsuneyo Mimori, and Tomotaka Kawayama
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Male ,Pulmonary and Respiratory Medicine ,Interferon-Induced Helicase, IFIH1 ,Antisynthetase syndrome ,Polymyositis ,Dermatomyositis ,Amino Acyl-tRNA Synthetases ,03 medical and health sciences ,0302 clinical medicine ,Cyclosporin a ,Diffusing capacity ,medicine ,Humans ,Autoantibodies ,Retrospective Studies ,030203 arthritis & rheumatology ,Lung ,biology ,business.industry ,Interstitial lung disease ,Middle Aged ,medicine.disease ,Polymyositis-Dermatomyositis ,Treatment Outcome ,medicine.anatomical_structure ,030228 respiratory system ,Immunology ,biology.protein ,Female ,Antibody ,Lung Diseases, Interstitial ,Tomography, X-Ray Computed ,business - Abstract
Background We attempted to clarify whether the presence of anti-aminoacyl-transfer RNA synthetase antibody (anti-ARS Ab) or anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) is associated with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). Methods We retrospectively investigated 22 patients with PM/DM-ILD (10 positive for anti-ARS Ab and nine positive for anti-MDA5 Ab) for whom antibody analysis of conserved serum was possible. We assessed mortality in the first three months as the therapeutic response in the acute phase and compared changes in clinical data for up to one year considered as the chronic phase. We classified the clinical changes over the year into three groups: Improvement (increased % vital capacity [%VC] or diffusing capacity of the lung for carbon monoxide [%D LCO ]≥10 or 15%), deterioration (decreased %VC or %D LCO ≥10 or 15%), and no change (remainder of the changes). The extent of abnormality demonstrated by high-resolution computed tomography (HRCT) was scored. Results Positivity for anti-MDA5 Ab, but not for anti-ARS Ab, was associated with mortality in the first 3 months. Evaluation of the therapeutic response in the first year showed that positivity for the anti-ARS Ab, but not for the anti-MDA5 Ab, was associated with an improvement in %D LCO and a decline in the serum KL-6 levels. Positivity for the anti-ARS Ab or negativity for anti-MDA5 Ab was associated with a greater decrease in bronchial dilatation as seen by HRCT. Conclusions Anti-ARS and anti-MDA5 Abs are associated with the therapeutic response of PM/DM-ILD.
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- 2017
17. Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance
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Li-Hua Zhang, Li Li, and Chun-Ye Wu
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Adult ,Male ,medicine.medical_specialty ,lcsh:Medicine ,030204 cardiovascular system & hematology ,PM/DM ,Gastroenterology ,Polymyositis ,behavioral disciplines and activities ,Dermatomyositis ,Pathogenesis ,Transforming Growth Factor beta1 ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,TGF-β1 ,medicine ,Humans ,030212 general & internal medicine ,Chemokine CCL2 ,business.industry ,Monocyte ,Research ,lcsh:R ,Interstitial lung disease ,General Medicine ,respiratory system ,medicine.disease ,respiratory tract diseases ,body regions ,Polymyositis-Dermatomyositis ,medicine.anatomical_structure ,Female ,Complication ,business ,ILD ,Transforming growth factor ,MCP-1 - Abstract
Objective This study aims to detect serum levels of monocyte chemoattractant protein-1 (MPC-1) and transforming growth factor-β1 (TGF-β1) in polymyositis/dermatomyositis (PM/DM) patients complicated with interstitial lung disease (ILD), to reveal the significance of the changes in these levels in the pathogenesis of PM/DM complicated with ILD. Methods Serum MCP-1 and TGF-β1 levels in PM/DM patients complicated with ILD, patients with pulmonary infections and normal controls (n = 30, each) were detected using enzyme-linked immunosorbent assay (ELISA), and the correlation between PM/DM complicated with ILD and serum MCP-1 and TGF-β1 levels was analyzed. Results Serum MCP-1 and TGF-β1 levels were both higher in PM/DM patients complicated with ILD compared with patients with pulmonary infections and normal controls. Conclusion Serum MCP-1 and TGF-β1 levels increased in PM/DM patients, and were closely correlated to the complication of ILD. This finding can be used for distinguishing between pulmonary infections and ILD, providing a new diagnostic method for the early prediction of DM/PM complicated with ILD.
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- 2019
18. Current Concepts and Trends in Management of Polymyositis/Dermatomyositis
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Chihiro Terai and Takahisa Gono
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030203 arthritis & rheumatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Polymyositis-Dermatomyositis ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Medicine ,General Medicine ,Current (fluid) ,business ,Dermatology - Published
- 2016
19. Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease
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Sonoko Nagai, Toyohiro Hirai, Kizuku Watanabe, Takeshi Kubo, Kazuhiro Hatta, Ryuji Uozumi, Yoshinari Nakatsuka, Akihiko Yoshizawa, Tsuneyo Mimori, Yuji Hosono, Yuko Murase, Yoshio Taguchi, Kiminobu Tanizawa, Michiaki Mishima, Ran Nakashima, Kazuo Chin, Kohei Ikezoe, Tatsuaki Tsuruyama, Akihiko Sokai, Kazuko Uno, Shinsaku Tokuda, and Tomohiro Handa
- Subjects
030203 arthritis & rheumatology ,medicine.medical_specialty ,biology ,business.industry ,Interstitial lung disease ,Odds ratio ,Matrix metalloproteinase ,medicine.disease ,Gastroenterology ,03 medical and health sciences ,Polymyositis-Dermatomyositis ,0302 clinical medicine ,030228 respiratory system ,Rheumatology ,Fibrosis ,Internal medicine ,medicine ,biology.protein ,Immunohistochemistry ,Pharmacology (medical) ,Clinical significance ,Antibody ,business - Abstract
Objective We aimed to clarify the clinical significance of serum levels of MMPs in interstitial lung disease (ILD) complicated with PM/DM (PM/DM-ILD). Methods We retrospectively analysed serum levels of seven subsets of MMPs in 52 PM/DM-ILD patients diagnosed at Kyoto University Hospital or Tenri Hospital from January 2005 to December 2014. The patients were sub-grouped based on the presence of anti-amimoacyl-tRNA synthetase antibody (anti-ARS antibody), anti-melanoma differentiation-associated protein 5 antibody (anti-MDA5 antibody) or lack of the antibodies (ARS-ILD, MDA5-ILD and other-ILD groups, respectively) and independently analysed. Eighteen PM/DM patients without ILD and 55 healthy control were also analysed. Associations between serum levels of MMPs and clinical findings including mortality were analysed. Results Among the MMPs analysed, MMP-7 serum levels in the ARS-ILD group were significantly higher compared with those in any of the other groups of PM/DM patients or in healthy controls. On the other hand, in the MDA5-ILD group, serum MMP-7 levels >5.08 ng/ml were associated with worse overall survival both in univariate (P = 0.017; odds ratio 18.0; 95% CI 1.69, 192.00) and multivariate (P = 0.027; odds ratio 14.60; 95% CI 1.11, 192.00) analyses. Immunohistochemical analysis suggested that MMP-7 was expressed in type II alveolar epithelial cells adjacent to the fibrotic lesions. Conclusion Serum MMP-7 levels were higher in anti-ARS antibody-positive PM/DM-ILD patients, while higher serum MMP-7 levels among anti-MDA5 antibody-positive PM/DM-ILD patients were associated with a worse prognosis. Fibrotic processes may be associated with the elevation of serum MMP-7 levels.
- Published
- 2018
20. Polymyositis, Dermatomyositis, Inclusion Body Myositis
- Author
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Abhisekh Ray and Ardhendu Ray
- Subjects
Polymyositis-Dermatomyositis ,medicine.medical_specialty ,business.industry ,medicine ,Inclusion body myositis ,medicine.disease ,business ,Dermatology - Published
- 2017
21. Anti-synthetase syndrome presenting as cryptogenic organizing pneumonia.
- Author
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Haydour, Qusay, Wells, Melissa A., McCoy, Sara S., Nelsen, Eric, Escalante, Patricio, and Matteson, Eric L.
- Subjects
CRYPTOGENIC organizing pneumonia ,INTERSTITIAL lung diseases ,AUTOIMMUNE diseases ,POLYMYOSITIS ,DERMATOMYOSITIS ,MEDICAL radiology ,IMMUNOGLOBULINS ,BIOPSY - Abstract
Abstract: Interstitial lung disease (ILD) is a unique group of lung diseases that can be associated with inflammatory conditions, such as polymyositis-dermatomyositis (PM-DM). Presentation of PM-DM with ILD is not uncommon but clinical and radiological features can be similar to other conditions (e.g. atypical pneumonia) and can be challenging to diagnose. Delayed diagnosis of PM-DM can be associated with progression of pulmonary involvement and potentially increase morbidity. We report a patient presenting with pulmonary symptoms who had positive anti-Jo-1 antibodies and cryptogenic organizing pneumonia features on biopsy, which is a rare reported finding. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
22. Treatment of Interstitial Lung Disease Associated with Polymyositis- Dermatomyositis: An Update
- Author
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Ichiei Narita, Toshinori Takada, and Eiichi Suzuki
- Subjects
Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Polymyositis-Dermatomyositis ,business.industry ,Interstitial lung disease ,medicine ,medicine.disease ,business - Published
- 2013
23. Interstitielle Lungenkrankheit bei Polymyositis/Dermatomyositis
- Author
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A. Schnabel
- Subjects
Gynecology ,Polymyositis-Dermatomyositis ,medicine.medical_specialty ,Rheumatology ,Non-specific interstitial pneumonia ,business.industry ,Interstitial lung disease ,Medicine ,business ,medicine.disease - Abstract
Bei konsequentem Screening weisen ca. 40 % der Patienten mit einer Polymyositis/Dermatomyositis (PM/DM) Zeichen einer interstitiellen Lungenkrankheit auf. In der Mehrzahl der Falle handelt es sich dabei um eine „non-specific interstitial pneumonia“, einen histopathologischen Typ, der initial durch ein Entzundungsbild charakterisiert ist und einer immunsuppressiven Therapie zuganglich ist. Die Diagnose der interstitiellen Lungenkrankheit (ILD) im entzundlichen Fruhstadium wird unterstutzt durch die Autoantikorperbestimmung (mehrheitlich Antisynthetaseantikorper), die differenzierte Spirometrie und die Dunnschicht-Computertomographie. Die Wertigkeit dieser Techniken fur die Fruherkennung und Prognoseabschatzung wird dargestellt, und die derzeit ausschlieslich empirischen Therapieoptionen werden erlautert.
- Published
- 2013
24. Polymyositis-dermatomyositis recognized during the follow-up of a patient with type 2 diabetes
- Author
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Mária Csóka, Katalin Dankó, and Francis Samer
- Subjects
medicine.medical_specialty ,business.industry ,Anti-Inflammatory Agents ,Autoimmunity ,General Medicine ,Type 2 diabetes ,Middle Aged ,medicine.disease ,Methylprednisolone ,Gastroenterology ,Dermatomyositis ,Drug Administration Schedule ,Surgery ,Diabetes Complications ,Polymyositis-Dermatomyositis ,Treatment Outcome ,Idiopathic inflammatory myopathies ,Diabetes Mellitus, Type 2 ,Internal medicine ,Humans ,Medicine ,Female ,business - Abstract
Polymyositis-dermatomyositis is a rare systemic autoimmune disease which belongs to the class of idiopathic inflammatory myopathies. The disease exhibits high inter-individual variability, but chronic myositis is a common feature. As different manifestations often appear in atypical forms, establishing the precise diagnosis can be rather complicated. The prognosis and the patient’s life expectations highly depend on whether the clinician considers this possibility in the diagnostic process or not. The authors present the case of a 50-year-old woman who was referred to hospital with suspected myopathy by her general practitioner. The history of the patient, the overall clinical picture and some marked laboratory abnormalities raised the possibility of polymyositis-dermatomyositis, which was unequivocally confirmed by immunological tests. Drug therapy was started immediately with the administration of high dose corticosteroid (1–2 mg/kg/day methylprednisolone), which was found to be an effective strategy leading to fast and remarkable improvement in the patient’s condition. From the first hospital day, the patient also received insulin therapy in order to prevent any potential corticosteroid-induced imbalance in her carbohydrate metabolism. The long-term patient management was provided by an interdisciplinary team the members of which (both clinicians and other health care professionals) worked according to a co-ordinated, complex care plan, and managed not only the “physiological functions” but the different psychological and social problems as well, which are usually associated with the disease. The follow-up period of this polyphase disease process lasted for 4.5 years, during which only two relapses occurred, and muscle strength typically varied between 3 and 4 on a five grade scale with the exception of the relapse periods. Good outcome was attributed to the strict follow-up and individualized therapy/care. Orv. Hetil., 2012, 153, 467–474.
- Published
- 2012
25. Polymyositis, Dermatomyositis, and Autoimmune Necrotizing Myopathy: Clinical Features
- Author
-
Lisa Christopher-Stine and Sabiha Khan
- Subjects
Pathology ,medicine.medical_specialty ,Weakness ,business.industry ,Dermatomyositis ,medicine.disease ,Polymyositis ,Autoimmune necrotizing myopathy ,Autoimmune Diseases ,Inflammatory myopathy ,Necrosis ,Polymyositis-Dermatomyositis ,Rheumatology ,medicine ,Humans ,Inclusion body myositis ,medicine.symptom ,Muscle, Skeletal ,business ,Myositis - Abstract
Idiopathic inflammatory myopathies are a heterogeneous group of autoimmune disorders predominantly affecting skeletal muscles, resulting in muscle inflammation and weakness. The 3 most common inflammatory myopathies are polymyositis (PM), dermatomyositis (DM), and inclusion body myositis. This review details the clinical findings noted in PM, DM, and the emerging entity of autoimmune necrotizing myopathy.
- Published
- 2011
26. Anti-glycyl tRNA synthetase antibody associated interstitial lung disease without symptoms of polymyositis/dermatomyositis
- Author
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Yuki Hara, Kazuhiro Tabata, Akira Shiraki, Tomonori Tanaka, Yukio Kashima, Kentaro Hayashi, Tomayoshi Hayashi, and Junya Fukuoka
- Subjects
Pathology ,medicine.medical_specialty ,biology ,business.industry ,Interstitial lung disease ,General Medicine ,medicine.disease ,Pathology and Forensic Medicine ,Polymyositis-Dermatomyositis ,Pneumonia ,Glycyl-tRNA synthetase ,Immunology ,medicine ,biology.protein ,Antibody ,business - Published
- 2014
27. Histomorphologie interstitieller Lungengerüstveränderungen und pulmonaler Vaskulitiden
- Author
-
K. Holl-Ulrich and I. Bittmann
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Churg-strauss syndrome ,medicine.disease ,Interstitial pneumonitis ,Polymyositis-Dermatomyositis ,Rheumatology ,Lung disease ,Wegener granulomatosis ,medicine ,business ,Wegener granulomatose ,Granulomatous vasculitis ,Rheumatoide arthritis - Abstract
Rheumatische Erkrankungen oder Kollagenosen sind eine heterogene Gruppe von Systemerkrankungen, bei denen die Lunge ein haufig mitbeteiligtes Organ ist. Die Beteiligung der Lunge kann vielfaltige Ursachen haben, wie Infektionen, Medikamententoxizitat und spezifische Manifestationen des der Grunderkrankung zugrunde liegenden immunologischen Prozesses. Dabei kann die Lunge in all ihren Gewebskompartimenten von einer Schadigung betroffen sein. Aufgrund ihrer auserordentlich breiten Differerenzialdiagnose stellen pulmonale vaskulitische Syndrome noch immer eine Herausforderung fur den Pathologen dar. Die Lunge ist haufig betroffen bei den mit ANCA-assoziierten primar systemischen Vaskuliden (PSV); die ubrigen PSV fuhren nur selten zu einer Mitbeteiligung der Lunge. Histomorphologisch konnen eine Kleingefasvaskulitis mit neutrophiler Alveolitis und diffuser alveolarer Hamorrhagie sowie extravaskulare intraparenchymale oder peribronchiale Granulome auf eine PSV hinweisen. Haufig sind in einer einzelnen Biopsie nicht alle diagnostischen Kriterien nachweisbar; daher ist die Wahl geeigneten Biopsiematerials sowie eine Korrelation mit den klinischen, serologischen und radiologischen Parametern unerlasslich. Nahezu alle Formen der idiopathischen interstitiellen Pneumonien finden sich auch als Muster der Lungenbeteiligung bei Kollagenosen, wobei sich in vielen Fallen nicht nur ein morphologisches Muster, sondern mehrere nebeneinander finden.
- Published
- 2009
28. Infections, connective tissue diseases and vasculitis
- Subjects
ANTICARDIOLIPIN ANTIBODIES ,antiphospholipid antibody syndrome ,ANTIPHOSPHOLIPID SYNDROME ,Wegener's granulomatosis ,vasculitis ,MIXED CRYOGLOBULINEMIA ,PARVOVIRUS B19 INFECTION ,MOLECULAR MIMICRY ,WEGENERS-GRANULOMATOSIS ,systemic lupus erythematosus ,polymyositis-dermatomyositis ,immunosuppressants ,infections ,SYSTEMIC-LUPUS-ERYTHEMATOSUS ,EPSTEIN-BARR-VIRUS ,MYCOPHENOLATE-MOFETIL ,STAPHYLOCOCCUS-AUREUS - Abstract
In genetically predisposed individuals, viruses, bacteria, or parasitic infectious agents are suspected of inducing autoimmunity and/or exacerbating autoimmune rheumatic diseases (ARD) once self tolerance is broken. Although direct evidence for this association is still lacking, numerous data from animal models as well as from humans support the hypothesis of a direct contribution of pathogens to the induction of several ARD.This review focuses on the possible role of infectious agents as triggers of autoimmunity in systemic lupus erythematosus, polymyositis-dermatomyositis, antiphospholipid antibody syndrome, and primary vasculitis. Indeed, vasculitis may be a clinical manifestation of tin infectious disease (secondary vasculitris).In addition, immune response abnormalities and immunosuppressive medications may be responsible for the high percentage of infectious complications in ARD patients. Recent therapeutic approaches aimed at lowering doses of cytotoxic agents and shortening duration of treatment with the most toxic drugs, have proved to be as effective as conventional regimens. New drugs and strategies aimed at preventing infections could further improve the outcome of ARD patients.
- Published
- 2008
29. 多発性筋炎・皮膚筋炎の研究の発展
- Author
-
Hitoshi Kohsaka and Naoko Okiyama
- Subjects
Muscle tissue ,B-Lymphocytes ,business.industry ,T-Lymphocytes ,Immunology ,General Medicine ,Disease ,Dermatomyositis ,medicine.disease ,Polymyositis ,Polymyositis-Dermatomyositis ,medicine.anatomical_structure ,Humoral immunity ,medicine ,Animals ,Humans ,Immunology and Allergy ,Immunohistochemistry ,Cytotoxic T cell ,business - Abstract
The idiopathic inflammatory myopathies, polymyositis (PM) and dermatomyositis (DM), are evaluated as systemic autoimmune diseases without the pathology determined. Past immunohistochemical findings suggested that the effector response is driven predominantly by CD4 T cells and by humoral immunity in DM, and by cytotoxic T cells in PM. However, histological observations of muscle tissue do not necessarily distinguish DM and PM. Thus, the two diseases including amyopathic DM might represent a spectrum of illness in which some patients suffer only from a muscle disease or from a skin disease. In comparison with research studies on other rheumatic diseases, there are much fewer research studies conducted on PM/DM. The relationship between PM and DM is not clear yet. We reviewed past clinical and basic research on the pathology of PM/DM, including research on relevant T cells, B cells and cytokines.
- Published
- 2008
30. Three cases of polymyositis/dermatomyositis complicated by pneumomediastinum
- Author
-
Yasuhiro Yagi, Shirou Fukuhara, Yoshio Ozaki, Seibun Yonezu, Tomoki Ito, Takashi Yokoi, Hideki Amuro, Keiko Shimamoto, Maiko Ota-Imamura, Tsutomu Tanijiri, and Yonsu Son
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Immunology ,General Medicine ,Middle Aged ,Dermatomyositis ,medicine.disease ,Dermatology ,respiratory tract diseases ,Polymyositis-Dermatomyositis ,Respiratory symptom ,Pneumothorax ,Humans ,Immunology and Allergy ,Medicine ,Female ,Interstitial pneumonia ,Pneumomediastinum ,medicine.symptom ,Complication ,business ,Mediastinal Emphysema ,Subcutaneous emphysema - Abstract
Pneumomediastinum is a rare complication of dermatomyositis (DM) and Polymiositis (PM). We report here three cases of PM/DM who developed pneumomediastinum. First case was 61 years old woman with amyopathic dermatomyositis (aDM). Her aDM was complicated with skin ulceration due to vasculopathy, but complicated interstitial pneumonia was not severe. She developed subcutaneous emphysema and pneumomediastinum. Second case was 57 years old woman with DM, who had intractable skin phenomena and mild interstitial pneumonia. The patient became subcutaneous emphysema and pneumomediastinum following severe vasculopathy of skin. The last case was 63 years old man with PM. His PM was complicated with interstitial pneumonia. He had intractable respiratory symptom. Ten years later, he became subcutaneous emphysema and pneumomediastinum following pneumothorax. First and second cases suggest that their pneumomediastinum were due to vasculopathy. On the other hand, pneumomediastinum of the last patient seemed to be associated with interstitial pneumonia and steroid.
- Published
- 2008
31. Infections, connective tissue diseases and vasculitis
- Subjects
ANTICARDIOLIPIN ANTIBODIES ,antiphospholipid antibody syndrome ,ANTIPHOSPHOLIPID SYNDROME ,Wegener's granulomatosis ,vasculitis ,MIXED CRYOGLOBULINEMIA ,PARVOVIRUS B19 INFECTION ,MOLECULAR MIMICRY ,WEGENERS-GRANULOMATOSIS ,systemic lupus erythematosus ,polymyositis-dermatomyositis ,immunosuppressants ,infections ,SYSTEMIC-LUPUS-ERYTHEMATOSUS ,EPSTEIN-BARR-VIRUS ,MYCOPHENOLATE-MOFETIL ,STAPHYLOCOCCUS-AUREUS - Abstract
In genetically predisposed individuals, viruses, bacteria, or parasitic infectious agents are suspected of inducing autoimmunity and/or exacerbating autoimmune rheumatic diseases (ARD) once self tolerance is broken. Although direct evidence for this association is still lacking, numerous data from animal models as well as from humans support the hypothesis of a direct contribution of pathogens to the induction of several ARD. This review focuses on the possible role of infectious agents as triggers of autoimmunity in systemic lupus erythematosus, polymyositis-dermatomyositis, antiphospholipid antibody syndrome, and primary vasculitis. Indeed, vasculitis may be a clinical manifestation of tin infectious disease (secondary vasculitris). In addition, immune response abnormalities and immunosuppressive medications may be responsible for the high percentage of infectious complications in ARD patients. Recent therapeutic approaches aimed at lowering doses of cytotoxic agents and shortening duration of treatment with the most toxic drugs, have proved to be as effective as conventional regimens. New drugs and strategies aimed at preventing infections could further improve the outcome of ARD patients.
- Published
- 2008
32. Distinct profiles of myositis-specific autoantibodies in Chinese and Japanese patients with polymyositis/dermatomyositis
- Author
-
Ziwei Guo, Masataka Kuwana, Lingyun Sun, Zhiyong Chen, Yan Wang, and Wei Hu
- Subjects
Male ,medicine.medical_specialty ,China ,Interferon-Induced Helicase, IFIH1 ,Enzyme-Linked Immunosorbent Assay ,Gastroenterology ,Polymyositis ,Dermatomyositis ,Cohort Studies ,DEAD-box RNA Helicases ,Rheumatology ,Asian People ,Japan ,Internal medicine ,medicine ,Humans ,Immunoprecipitation ,Autoantibodies ,business.industry ,Autoantibody ,General Medicine ,Middle Aged ,medicine.disease ,Polymyositis-Dermatomyositis ,Immunology ,Cohort ,Female ,Myositis specific autoantibodies ,business ,Cohort study - Abstract
The study aims to comprehensively assess the profiles of myositis-specific autoantibodies (MSAs) in Chinese patients with polymyositis (PM)/dermatomyositis (DM) and compare them with a Japanese cohort. One hundred forty-five Chinese patients (68 classic DM, 25 clinically amyopathic DM [CADM], and 52 PM) and 165 Japanese patients (56 classic DM, 52 CADM, and 57 PM) were recruited. MSAs were measured with immunoprecipitation, enzyme-linked immunosorbent assay, or immunoprecipitation-immunoblotting. MSA frequencies were compared. The overall frequency of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was significantly higher in the Chinese patients than in the Japanese cohort (36.6 % [53/145] versus 15.8 % [26/165], respectively, P 0.001), whereas the frequencies of anti-signal recognition particle (SRP) antibodies (1.4 % [2/145] versus 7.9 % [13/165], respectively, P = 0.008) and anti-aminoacyl-transfer RNA synthetase (anti-ARS) antibodies (27.6 % [40/145] versus 40 % [66/165], respectively, P = 0.02,) were significantly lower. The significantly lower frequency of anti-ARS antibodies and significantly higher frequency of anti-MDA5 antibodies in the Chinese patients were observed in the classic DM subset (14.7 % [10/68] versus 46.4 % [26/56], respectively, P 0.001, and 45.6 % [31/68] versus 5.4 % [3/56], respectively, P 0.001) and CADM subset (8.0 % [2/25] versus 28.8 % [15/52], respectively, P = 0.04, and 88.0 % [22/25] versus 44.2 % [23/52], respectively, P = 0.0002), but not in the PM subset. The first detailed profile of MSAs in Chinese patients with PM/DM was established. The differences in MSA frequencies in the Chinese cohort and Japanese cohort suggest underlying genetic and/or environmental differences between these two populations. Key Messages • A significantly higher frequency of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was observed in Chinese patients with polymyositis/dermatomyositis (PM/DM) than in Japanese patients. • Our findings suggest that distinct genetic and/or local environmental factors affect Chinese and Japanese patients with PM/DM, who have been considered a "homogeneous" population in previous studies.
- Published
- 2015
33. Bronchiolitis obliterans organizing pneumonia in patients with autoimmune rheumatic diseases
- Author
-
Ricardo Gómez-Huelgas, Silvio Ragozzino, Leonardo Punzi, Elisabetta Borella, Lavinia Palma, Carmen Maria Lara Rojas, Enrique de Ramón, and Andrea Doria
- Subjects
Pathology ,medicine.medical_specialty ,Lung ,business.industry ,Immunology ,Bronchiolitis obliterans organizing pneumonia ,Granulation tissue ,medicine.disease ,Dermatology ,Autoimmune Diseases ,Broad spectrum ,Polymyositis-Dermatomyositis ,medicine.anatomical_structure ,Cryptogenic Organizing Pneumonia ,Rheumatic Diseases ,medicine ,Humans ,In patient ,Organizing pneumonia ,business - Abstract
Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to corticosteroids and an excellent prognosis. It can occur in association with a broad spectrum of clinical conditions or can be isolated, in this last case named cryptogenic organizing pneumonia. We searched for BOOP in patients with autoimmune rheumatic diseases (ARD) in the literature, and we found 32 well-documented cases. We reported here demographic features, manifestations, treatment and outcome of patients with BOOP associated with ARD. Notably, BOOP can be the presenting feature in some patients with ARD; thus, a close follow-up of patients with BOOP is recommended.
- Published
- 2015
34. Infections in Systemic Connective Tissue Diseases: Systemic Lupus Erythematosus, Scleroderma, and Polymyositis/Dermatomyositis
- Author
-
Graciela S. Alarcón
- Subjects
Microbiology (medical) ,business.industry ,medicine.drug_class ,Connective tissue ,medicine.disease ,Scleroderma ,Polymyositis-Dermatomyositis ,Infectious Diseases ,Increased risk ,medicine.anatomical_structure ,Immune system ,Immunology ,medicine ,Proper treatment ,Corticosteroid ,business ,Organ system - Abstract
In SLE, scleroderma, and PM/DM, infections are important causes of morbidity and mortality. This increased risk for developing infections is the result of immune abnormalities and of organ system manifestations associated with these diseases and their treatments. Common bacteria are responsible for most mild and lethal infections; however, opportunistic microorganisms cause death in some patients, particularly in those receiving high doses of corticosteroid and immunosuppressive therapy. Various viral and fungal infections also contribute to the morbidity and mortality associated with these diseases. Regardless of the cause of infections, adequate and prompt recognition and proper treatment of the infected patient are imperative. Patients who have these diseases, especially when receiving high doses of corticosteroids and immunosuppressive therapy, need to be monitored closely for these infections. This care and concern is necessary to ensure optimal patient outcomes, both in morbidity and mortality.
- Published
- 2006
35. Pulmonary Manifestations of Polymyositis/Dermatomyositis
- Author
-
Michael J. Morris, Kimberly Kehoe, Jonathan Brewer, Ethan E. Emmons, Sahar Abouchahine, and Patrick F. Allan
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Polymyositis-Dermatomyositis ,business.industry ,Medicine ,Critical Care and Intensive Care Medicine ,business ,Dermatology - Published
- 2006
36. Echocardiographic abnormalities in new-onset polymyositis/dermatomyositis
- Author
-
Ágnes Balogh, István Édes, Melinda Nagy-Vincze, Andrea Péter, Réka Faludi, Katalin Dankó, and Szabolcs Szilágyi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heart Ventricles ,Immunology ,Diastole ,Polymyositis ,Doppler imaging ,Dermatomyositis ,New onset ,Rheumatology ,Internal medicine ,Ventricular Dysfunction ,Immunology and Allergy ,Medicine ,Humans ,Tricuspid valve ,Ejection fraction ,business.industry ,medicine.disease ,Polymyositis-Dermatomyositis ,medicine.anatomical_structure ,Echocardiography ,Cardiology ,Female ,Tricuspid Valve ,business - Abstract
Objective.To identify early echocardiographic abnormalities at the time of diagnosis of polymyositis (PM) and dermatomyositis (DM) and follow the echocardiographic findings during the first 3 months of therapy.Methods.We included 30 PM/DM patients (23/7) with a mean age of 42.3 ± 1.6 years and without cardiovascular symptoms. Age-matched healthy patients served as controls. Clinical characteristics were recorded. Traditional echocardiography and tissue Doppler imaging (TDI) were performed to measure systolic [ejection fraction, right ventricular fractional area change (RV FAC), lateral and tricuspid annulus s velocities] and diastolic echocardiographic variables (mitral inflow velocities: E, A; deceleration time: DT; lateral and tricuspid annulus e′, a′ velocities, lateral E/e′).Results.The left and right ventricular systolic dysfunction detected by TDI at the time of the PM/DM diagnosis improved, and characteristic values at the end of the followup period were comparable to those of the controls (lateral s: 10.6 ± 0.2, 8.7 ± 0.4, 9.6 ± 0.3, 11.3 ± 0.2 cm/s; RV FAC: 45.2 ± 2.3, 36.9 ± 1.5, 42.2 ± 1.3, 46.9 ± 1.2%; tricuspid s: 13.3 ± 0.2, 9.5 ± 0.4, 10.3 ± 0.3, 11.6 ± 0.5 cm/s; control, 0, 1, and 3 mos, respectively). Measurements indicated the development of diastolic dysfunction at 3 mos (E/A: 1.4 ± 0.1, 1.29 ± 0.05, 1.03 ± 0.05, 0.92 ± 0.05; DT: 148.6 ± 3.6, 157.3 ± 5.7, 168.3 ± 6.0, 184.3 ± 6.2 ms; lateral e′: 12.8 ± 0.3, 12.1 ± 0.5, 10.2 ± 0.6, 10.8 ± 0.8 cm/s; E/e′: 5.6 ± 0.1, 5.0 ± 0.22, 6.92 ± 0.46, 7.64 ± 0.47; control, 0, 1, and 3 mos, respectively).Conclusion.TDI is a useful method to detect early cardiac abnormalities complementing the conventional echocardiographic measurements. LV and RV systolic dysfunction found in the acute phase significantly improved during the first 3 months of therapy; however, deterioration of diastolic dysfunction was also observed.
- Published
- 2014
37. Fall 52 Polymyositis, Dermatomyositis
- Author
-
Andreas Bickel and Roland Gerlach
- Subjects
Polymyositis-Dermatomyositis ,medicine.medical_specialty ,business.industry ,medicine ,business ,Dermatology - Published
- 2014
38. Treatment of interstitial pneumonia associated with polymyositis/dermatomyositis with cyclosporin A
- Author
-
Masako Hara, Kae Takagi, and Masayoshi Harigai
- Subjects
medicine.medical_specialty ,Collagen disease ,business.industry ,Immunology ,Treatment outcome ,General Medicine ,Drug resistance ,Dermatomyositis ,medicine.disease ,Dermatology ,Polymyositis ,Drug Resistance, Multiple ,Polymyositis-Dermatomyositis ,Treatment Outcome ,Cyclosporin a ,Cyclosporine ,medicine ,Humans ,Immunology and Allergy ,Steroids ,Interstitial pneumonia ,Lung Diseases, Interstitial ,business - Published
- 1999
39. Tumor necrosis factor-alpha-308G/A promoter polymorphism is associated with the susceptibility of polymyositis/dermatomyositis in a Chinese Han population
- Author
-
Yong-Wei Li, Ai-E Xu, Ji‐Feng Liu, Xiao‐Hang Du, Yang‐Jie Ou, and Xu Tang
- Subjects
Polymyositis-Dermatomyositis ,Chinese han population ,business.industry ,Promoter polymorphism ,Cancer research ,Medicine ,Tumor necrosis factor alpha ,Dermatology ,General Medicine ,business - Published
- 2007
40. Cyclosporin A therapy for interstitial pneumonitis in patients with polymyositis/dermatomyositis(PM/DM)
- Author
-
Koichi Amano, Isao Ito, Tsutomu Takeuchi, Tohru Abe, Jun Koide, Yasuhide Takano, Tatsuya Ito, Hiroshi Maruyama, Keiko Saito, and Kazutoshi Aoki
- Subjects
medicine.medical_specialty ,Polymyositis-Dermatomyositis ,business.industry ,Internal medicine ,Cyclosporin a ,medicine ,In patient ,business ,Gastroenterology ,Interstitial pneumonitis - Published
- 1997
41. Polymyositis, Dermatomyositis, and Inclusion Body Myositis
- Author
-
Janice L. Holton, Lucy R. Wedderburn, and Michael G. Hanna
- Subjects
Pathology ,medicine.medical_specialty ,Muscle biopsy ,medicine.diagnostic_test ,business.industry ,Dermatomyositis ,medicine.disease ,Polymyositis ,Polymyositis-Dermatomyositis ,medicine ,Idiopathic Inflammatory Myopathy ,Inclusion body myositis ,business ,Juvenile dermatomyositis - Published
- 2013
42. Multiple myositis and dermatomyositis and autoantibody
- Author
-
M. Akizuki, M. Hirakata, and K. Mitsumori
- Subjects
Polymyositis-Dermatomyositis ,business.industry ,Immunology ,Autoantibody ,Immunology and Allergy ,Medicine ,General Medicine ,business - Published
- 1996
43. The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis
- Author
-
Satoshi Ubukata, Takao Fujii, Machiko Arita, Tsuneyo Mimori, Satoshi Konishi, Mika Saigusa, Yasushi Fukuda, Kei Kunimasa, Maki Tanaka, Kazuya Tsubouchi, Takashi Nakazawa, Tadashi Ishida, Hiroaki Nakagawa, and Yohei Korogi
- Subjects
Isoleucine-tRNA Ligase ,Male ,Pathology ,medicine.medical_specialty ,Polymyositis ,Dermatomyositis ,Internal Medicine ,medicine ,Humans ,Aged ,Autoantibodies ,business.industry ,Isoleucyl-tRNA synthetase ,Interstitial lung disease ,Clinical course ,Autoantibody ,Sclerodactyly ,General Medicine ,medicine.disease ,Polymyositis-Dermatomyositis ,Female ,medicine.symptom ,business ,Lung Diseases, Interstitial - Abstract
We herein report the clinical and laboratory characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis (PM/DM). We compared these characteristics with previously published findings. Previous reports and our present cases show that anti-OJ autoantibody-positive interstitial lung disease (ILD) patients with PM/DM lack the manifestations of Raynaud's phenomenon and sclerodactyly and show good prognoses and responses to glucocorticoid therapy. These results indicate that the presence of anti-OJ autoantibodies may be useful for predicting the prognosis of ILD and its clinical course in PM/DM patients.
- Published
- 2012
44. 6 Inflammatory myopathies (polymyositis, dermatomyositis)
- Author
-
Rudolf Mierau and Ekkehard Genth
- Subjects
medicine.medical_specialty ,Polymyositis-Dermatomyositis ,business.industry ,medicine ,business ,Dermatology - Published
- 2012
45. Marked increase in serum KL-6 and surfactant protein D levels during the first 4 weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/dermatomyositis
- Author
-
Kazuhiro Kurasawa, Satoko Arai, Takayoshi Owada, H. Okada, Takeshi Fukuda, and Reika Maezawa
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Poor prognosis ,Polymyositis ,Dermatomyositis ,Rheumatology ,Medicine ,Humans ,Interstitial pneumonia ,In patient ,Aged ,Retrospective Studies ,business.industry ,Mucin-1 ,Surfactant protein D ,Middle Aged ,medicine.disease ,Prognosis ,Pulmonary Surfactant-Associated Protein D ,Polymyositis-Dermatomyositis ,Treatment Outcome ,Female ,business ,Lung Diseases, Interstitial ,After treatment - Abstract
The aim of this study is to determine whether serum KL-6 and surfactant protein D (SP-D) levels predict the prognosis of patients with interstitial pneumonia (IP) in cases of polymyositis (PM) and dermatomyositis (DM).Fifty consecutive patients with PM (n = 17) or DM (n = 33) and active IP, 6 of whom died of respiratory failure, were enrolled in this study. Serum KL-6 and SP-D levels were measured every 2-4 weeks. Medical records were reviewed retrospectively. Univariate analyses and multivariate analyses with a logistic regression model were conducted.Serum KL-6 and SP-D levels were elevated in patients with active IP. At the time of diagnosis of active IP, the serum KL-6 level was within the normal range in 28 % of patients and the SP-D level was within the normal range in 46 % of patients. Serum KL-6 level increased up to 3 months after starting treatment and then decreased gradually to baseline, whereas SP-D level peaked within the first 4 weeks after treatment and decreased rapidly to normal levels. Patients with poor prognosis showed increases in KL-6 and SP-D levels during the first 4 weeks after treatment, which was confirmed by uni- and multivariate analyses. Comparing the marker levels at 2-4 weeks after treatment with those at 0 weeks, an increase in the ratio over 1.70 for KL-6 and over 1.75 for SP-D, and an increase in KL-6 over 850 U/ml during the first 4 weeks after treatment, were poor prognostic factors.Increases in serum KL-6 and SP-D levels during the first 4 weeks after starting therapy, but not their levels at any one time point, predict poor prognosis in patients with PM/DM. When marked increases of KL-6 and SP-D levels during the first 4 weeks are found or are predicted by serial measurement of the markers, patients have risks of poor prognosis and additional therapy should be considered.
- Published
- 2012
46. Retrospective Longitudinal Study Of Polymyositis/Dermatomyositis Associated Interstitial Lung Disease
- Author
-
Joseph Parambil, Meng Xu, Jeffrey T. Chapman, Ruchi Yadav, Isabel Mira-Avendano, and Daniel A. Culver
- Subjects
Polymyositis-Dermatomyositis ,Longitudinal study ,Pathology ,medicine.medical_specialty ,business.industry ,Interstitial lung disease ,Medicine ,business ,medicine.disease - Published
- 2012
47. Is there an association between injectable collagen and polymyositis/dermatomyositis?
- Author
-
Morris Reichlin and Mph Michael J. Rosenberg Md
- Subjects
Adult ,Male ,medicine.medical_specialty ,Systemic disease ,Bovine collagen ,Adolescent ,Immunology ,Population ,Sensitivity and Specificity ,Polymyositis ,Dermatomyositis ,Rheumatology ,Internal medicine ,Epidemiology ,Confidence Intervals ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,Risk factor ,education ,Aged ,education.field_of_study ,Models, Statistical ,business.industry ,Middle Aged ,medicine.disease ,Polymyositis-Dermatomyositis ,Female ,Collagen ,business ,Follow-Up Studies - Abstract
Objective. Recent case reports have raised the possibility that use of injectable bovine collagen may be associated with polymyositis/dermatomyositis (PM/DM). Because the number of collagen users is high, PM/DM would be expected to occur in some for reasons unrelated to the collagen use. A central issue is whether the number of observed cases exceeds the number expected on the basis of background rates alone. The present study was undertaken to investigate this. Methods. The number of observed cases was determined by review of the medical records of collagen users who had reported illnesses consistent with PM/DM. Because of the uncertainty about diagnosis of PM/DM, population incidence rates, number of patients treated with collagen, and duration of followup after treatment, we examined a range of estimates of each of these factors that would affect the expected number of cases. Results. From reports among collagen users, 7 probable or definite cases of PM/DM were confirmed. In contrast, 13 cases would be expected based on the best estimates of relevant factors. Under the most conservative estimates for factors that influence the number of expected cases, 12 cases would be expected, while worst-case assumptions would yield an expected 130 cases. Conclusion. The consistent finding of fewer-than-expected PM/DM cases among collagen users suggests that collagen use is not associated with the development of PM/DM.
- Published
- 1994
48. Polymyositis, Dermatomyositis und Einschlußkörperchenmyositis*
- Author
-
M. C. Dalakas
- Subjects
Polymyositis-Dermatomyositis ,medicine.medical_specialty ,Rheumatology ,business.industry ,medicine ,business ,Dermatology - Published
- 1992
49. Pulmonary hypertension in polymyositis-dermatomyositis: clinical and hemodynamic characteristics and response to vasoactive therapy
- Author
-
OA Minai
- Subjects
Adult ,medicine.medical_specialty ,Hypertension, Pulmonary ,Vasodilator Agents ,Hemodynamics ,Scleroderma ,Dermatomyositis ,Fatal Outcome ,Rheumatology ,Internal medicine ,Vasoactive ,medicine ,Humans ,Scleroderma, Systemic ,business.industry ,Incidence (epidemiology) ,Interstitial lung disease ,Cardiovascular Agents ,Middle Aged ,medicine.disease ,Connective tissue disease ,Pulmonary hypertension ,Polymyositis-Dermatomyositis ,Cardiology ,Female ,business - Abstract
The increased incidence of pulmonary hypertension and its association with decreased survival is well-recognised in patients with systemic sclerosis. This association is not widely appreciated in patients with polymyositis-dermatomyositis. We report clinical and hemodynamic characteristics and response to vasoactive therapy in three patients with polymyositis-dermatomyositis and pulmonary hypertension and discuss them in light of the available literature.
- Published
- 2009
50. Polymyositis, Dermatomyositis, and Inclusion-Body Myositis
- Author
-
Marinos C. Dalakas
- Subjects
Inclusion Bodies ,Pathology ,medicine.medical_specialty ,Heterogeneous group ,Myositis ,Response to therapy ,business.industry ,Muscle weakness ,General Medicine ,Dermatomyositis ,medicine.disease ,Polymyositis ,Polymyositis-Dermatomyositis ,medicine ,Humans ,Inclusion body myositis ,medicine.symptom ,business - Abstract
THE polymyositis and dermatomyositis complex encompasses a heterogeneous group of acquired muscle diseases called inflammatory myopathies because muscle weakness and inflammatory infiltrates within the skeletal muscles are the principal clinical and histologic findings.1 2 3 4 5 6 7 8 9 10 11 12 Traditionally, polymyositis and dermatomyositis have been viewed as pathogenetically similar and part of the spectrum of "idiopathic" inflammatory myopathies,9 , 10 , 13 , 14 despite the variability in their clinical and laboratory characteristics, prognosis, and response to therapy. With the evolution over the past 10 years of rather well defined clinical, demographic, histologic, and immunopathological criteria and the identification of inclusion-body myositis as a distinct type of polymyositis,15 the inflammatory myopathies now . . .
- Published
- 1991
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