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1. Automated office blood pressure measurements in primary care are misleading in more than one third of treated hypertensives: The VALENTINE-Greece Home Blood Pressure Monitoring study

Author

Demerouti, E., Voulgaris, D., Papadakis, I., Karsanidis, A., Triantafillou, A., Garzonis, S., Gourgoulis, G., Trikalinou, A., Karidas, P., Savvalas, D., Aggelopoulos, T., Alevizos, A., Moraiti, A., Rosmarakis, E., Chatzigeorgiou, G., Antonakis, V., Alexandropoulou-Tsirka, A., Markaki, I., Astrinakis, S., Roilidis, V., Polymeros, S., Chariatis, E., Panageas, V., Kontoriga, A., Patsioura, M., Kleftaki-Manta, A., Kalantaridou, A., Kourouklis, S., Papakonstantinos, G., Barouni, P., Grekidou, E., Sklaveniti, A., Kolovou, I., Antoniadis, A., Pelekanos, I., Zervaki Drakou, N., Tikka-Zoumpou, K., Dalaklidou, V., Menti, A., Christofeli, A., Androutsakos, T., Doulgerakis, D., Oikonomopoulou, I., Moschos, M., Koutras, D., Skias, I., Boutsikos, P., Matsaggoura-Sameli, M., Riga, M., Sainis, P., Mitilinaiou-Karakozi, E., Mainas, K., Nikolaou, K., Chatziparaskevas, S., Ozai, O., Vogiatzis, G., Lilis, L., Plaskas, D., Chatzizisi, S., Gianasmidis, A., Petrovitsos, E., Koykoyfikis, G., Pittas, A., Rovithis, D., Ioannidis, A., Dalamaga, E., Kladas, G., Afthonidis, N., Pourou, E., Katainidis, S., Gavrilidou, M., Kourtidou, P., Tsamopoulos, L., Kairis, K., Arampatzi, S., Basoukos, C., Daskalakis, K., Megianis, V., Simintiridou, D., Christoforidis, T., Lafazanis, G., Chatzioannidis, L., Stephopoulos, C., Karanika-Chandolia, K., Teneketzi, E., Mellidis, C., Tsepelis, P., Louspas, C., Biternas, M., Xionis, T., Tsantilas, D., Kosmanou, M., Gougousis, I., Chatzi, F., Vassos, A., Bitchavas, S., Dalaveris, E., Spiroulias, G., Anastasopoulos, I., Karlis, D., Chiotis, D., Christodoulou, G., Arfanakis, D., Psarogianni-Sinou, V., Kokkinos, S., Anifantis, I., Alogogianni, P., Michas, A., Oikonomou, A., Charalampous, A., Papadopoulos, P., Philipoiou Kotsoni, M., Dragonas, P., Laskari, E., Tsiamtsiouri, G., Kritsova-Avgerou, V., Tiligadas, T., Vrettos, N., Vernardos, N., Melessanakis, M., Melidoniotis, A., Liodakis, E., Manousakis, A., Galanakis, C., Lampousakis, I., Vyzoukakis, E., Strimpouli, G., Patramanis, I., Chatziliadou, D., Nioti, K., Koynalakis, D., Tserkis, I., Androutsopoulou, C., Liavvas, C., Karaoglanidou, D., Kollias, A., Papadatos, S.S., Dominiczak, A.F., Parati, G., and Stergiou, G.S.

Published
2020
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2. Automated office blood pressure measurements in primary care are misleading in more than one third of treated hypertensives: The VALENTINE-Greece Home Blood Pressure Monitoring study

Author

Kollias, A, Papadatos, S, Dominiczak, A, Parati, G, Stergiou, G, Demerouti, E, Voulgaris, D, Papadakis, I, Karsanidis, A, Triantafillou, A, Garzonis, S, Gourgoulis, G, Trikalinou, A, Karidas, P, Savvalas, D, Aggelopoulos, T, Alevizos, A, Moraiti, A, Rosmarakis, E, Chatzigeorgiou, G, Antonakis, V, Alexandropoulou-Tsirka, A, Markaki, I, Astrinakis, S, Roilidis, V, Polymeros, S, Chariatis, E, Panageas, V, Kontoriga, A, Patsioura, M, Kleftaki-Manta, A, Kalantaridou, A, Kourouklis, S, Papakonstantinos, G, Barouni, P, Grekidou, E, Sklaveniti, A, Kolovou, I, Antoniadis, A, Pelekanos, I, Zervaki Drakou, N, Tikka-Zoumpou, K, Dalaklidou, V, Menti, A, Christofeli, A, Androutsakos, T, Doulgerakis, D, Oikonomopoulou, I, Moschos, M, Koutras, D, Skias, I, Boutsikos, P, Matsaggoura-Sameli, M, Riga, M, Sainis, P, Mitilinaiou-Karakozi, E, Mainas, K, Nikolaou, K, Chatziparaskevas, S, Ozai, O, Vogiatzis, G, Lilis, L, Plaskas, D, Chatzizisi, S, Gianasmidis, A, Petrovitsos, E, Koykoyfikis, G, Pittas, A, Rovithis, D, Ioannidis, A, Dalamaga, E, Kladas, G, Afthonidis, N, Pourou, E, Katainidis, S, Gavrilidou, M, Kourtidou, P, Tsamopoulos, L, Kairis, K, Arampatzi, S, Basoukos, C, Daskalakis, K, Megianis, V, Simintiridou, D, Christoforidis, T, Lafazanis, G, Chatzioannidis, L, Stephopoulos, C, Karanika-Chandolia, K, Teneketzi, E, Mellidis, C, Tsepelis, P, Louspas, C, Biternas, M, Xionis, T, Tsantilas, D, Kosmanou, M, Gougousis, I, Chatzi, F, Vassos, A, Bitchavas, S, Dalaveris, E, Spiroulias, G, Anastasopoulos, I, Karlis, D, Chiotis, D, Christodoulou, G, Arfanakis, D, Psarogianni-Sinou, V, Kokkinos, S, Anifantis, I, Alogogianni, P, Michas, A, Oikonomou, A, Charalampous, A, Papadopoulos, P, Philipoiou Kotsoni, M, Dragonas, P, Laskari, E, Tsiamtsiouri, G, Kritsova-Avgerou, V, Tiligadas, T, Vrettos, N, Vernardos, N, Melessanakis, M, Melidoniotis, A, Liodakis, E, Manousakis, A, Galanakis, C, Lampousakis, I, Vyzoukakis, E, Strimpouli, G, Patramanis, I, Chatziliadou, D, Nioti, K, Koynalakis, D, Tserkis, I, Androutsopoulou, C, Liavvas, C, Karaoglanidou, D, Kollias A., Papadatos S. S., Dominiczak A. F., Parati G., Stergiou G. S., Demerouti E., Voulgaris D., Papadakis I., Karsanidis A., Triantafillou A., Garzonis S., Gourgoulis G., Trikalinou A., Karidas P., Savvalas D., Aggelopoulos T., Alevizos A., Moraiti A., Rosmarakis E., Chatzigeorgiou G., Antonakis V., Alexandropoulou-Tsirka A., Markaki I., Astrinakis S., Roilidis V., Polymeros S., Chariatis E., Panageas V., Kontoriga A., Patsioura M., Kleftaki-Manta A., Kalantaridou A., Kourouklis S., Papakonstantinos G., Barouni P., Grekidou E., Sklaveniti A., Kolovou I., Antoniadis A., Pelekanos I., Zervaki Drakou N., Tikka-Zoumpou K., Dalaklidou V., Menti A., Christofeli A., Androutsakos T., Doulgerakis D., Oikonomopoulou I., Moschos M., Koutras D., Skias I., Boutsikos P., Matsaggoura-Sameli M., Riga M., Sainis P., Mitilinaiou-Karakozi E., Mainas K., Nikolaou K., Chatziparaskevas S., Ozai O., Vogiatzis G., Lilis L., Plaskas D., Chatzizisi S., Gianasmidis A., Petrovitsos E., Koykoyfikis G., Pittas A., Rovithis D., Ioannidis A., Dalamaga E., Kladas G., Afthonidis N., Pourou E., Katainidis S., Gavrilidou M., Kourtidou P., Tsamopoulos L., Kairis K., Arampatzi S., Basoukos C., Daskalakis K., Megianis V., Simintiridou D., Christoforidis T., Lafazanis G., Chatzioannidis L., Stephopoulos C., Karanika-Chandolia K., Teneketzi E., Mellidis C., Tsepelis P., Louspas C., Biternas M., Xionis T., Tsantilas D., Kosmanou M., Gougousis I., Chatzi F., Vassos A., Bitchavas S., Dalaveris E., Spiroulias G., Anastasopoulos I., Karlis D., Chiotis D., Christodoulou G., Arfanakis D., Psarogianni-Sinou V., Kokkinos S., Anifantis I., Alogogianni P., Michas A., Oikonomou A., Charalampous A., Papadopoulos P., Philipoiou Kotsoni M., Dragonas P., Laskari E., Tsiamtsiouri G., Kritsova-Avgerou V., Tiligadas T., Vrettos N., Vernardos N., Melessanakis M., Melidoniotis A., Liodakis E., Manousakis A., Galanakis C., Lampousakis I., Vyzoukakis E., Strimpouli G., Patramanis I., Chatziliadou D., Nioti K., Koynalakis D., Tserkis I., Androutsopoulou C., Liavvas C., Karaoglanidou D., Kollias, A, Papadatos, S, Dominiczak, A, Parati, G, Stergiou, G, Demerouti, E, Voulgaris, D, Papadakis, I, Karsanidis, A, Triantafillou, A, Garzonis, S, Gourgoulis, G, Trikalinou, A, Karidas, P, Savvalas, D, Aggelopoulos, T, Alevizos, A, Moraiti, A, Rosmarakis, E, Chatzigeorgiou, G, Antonakis, V, Alexandropoulou-Tsirka, A, Markaki, I, Astrinakis, S, Roilidis, V, Polymeros, S, Chariatis, E, Panageas, V, Kontoriga, A, Patsioura, M, Kleftaki-Manta, A, Kalantaridou, A, Kourouklis, S, Papakonstantinos, G, Barouni, P, Grekidou, E, Sklaveniti, A, Kolovou, I, Antoniadis, A, Pelekanos, I, Zervaki Drakou, N, Tikka-Zoumpou, K, Dalaklidou, V, Menti, A, Christofeli, A, Androutsakos, T, Doulgerakis, D, Oikonomopoulou, I, Moschos, M, Koutras, D, Skias, I, Boutsikos, P, Matsaggoura-Sameli, M, Riga, M, Sainis, P, Mitilinaiou-Karakozi, E, Mainas, K, Nikolaou, K, Chatziparaskevas, S, Ozai, O, Vogiatzis, G, Lilis, L, Plaskas, D, Chatzizisi, S, Gianasmidis, A, Petrovitsos, E, Koykoyfikis, G, Pittas, A, Rovithis, D, Ioannidis, A, Dalamaga, E, Kladas, G, Afthonidis, N, Pourou, E, Katainidis, S, Gavrilidou, M, Kourtidou, P, Tsamopoulos, L, Kairis, K, Arampatzi, S, Basoukos, C, Daskalakis, K, Megianis, V, Simintiridou, D, Christoforidis, T, Lafazanis, G, Chatzioannidis, L, Stephopoulos, C, Karanika-Chandolia, K, Teneketzi, E, Mellidis, C, Tsepelis, P, Louspas, C, Biternas, M, Xionis, T, Tsantilas, D, Kosmanou, M, Gougousis, I, Chatzi, F, Vassos, A, Bitchavas, S, Dalaveris, E, Spiroulias, G, Anastasopoulos, I, Karlis, D, Chiotis, D, Christodoulou, G, Arfanakis, D, Psarogianni-Sinou, V, Kokkinos, S, Anifantis, I, Alogogianni, P, Michas, A, Oikonomou, A, Charalampous, A, Papadopoulos, P, Philipoiou Kotsoni, M, Dragonas, P, Laskari, E, Tsiamtsiouri, G, Kritsova-Avgerou, V, Tiligadas, T, Vrettos, N, Vernardos, N, Melessanakis, M, Melidoniotis, A, Liodakis, E, Manousakis, A, Galanakis, C, Lampousakis, I, Vyzoukakis, E, Strimpouli, G, Patramanis, I, Chatziliadou, D, Nioti, K, Koynalakis, D, Tserkis, I, Androutsopoulou, C, Liavvas, C, Karaoglanidou, D, Kollias A., Papadatos S. S., Dominiczak A. F., Parati G., Stergiou G. S., Demerouti E., Voulgaris D., Papadakis I., Karsanidis A., Triantafillou A., Garzonis S., Gourgoulis G., Trikalinou A., Karidas P., Savvalas D., Aggelopoulos T., Alevizos A., Moraiti A., Rosmarakis E., Chatzigeorgiou G., Antonakis V., Alexandropoulou-Tsirka A., Markaki I., Astrinakis S., Roilidis V., Polymeros S., Chariatis E., Panageas V., Kontoriga A., Patsioura M., Kleftaki-Manta A., Kalantaridou A., Kourouklis S., Papakonstantinos G., Barouni P., Grekidou E., Sklaveniti A., Kolovou I., Antoniadis A., Pelekanos I., Zervaki Drakou N., Tikka-Zoumpou K., Dalaklidou V., Menti A., Christofeli A., Androutsakos T., Doulgerakis D., Oikonomopoulou I., Moschos M., Koutras D., Skias I., Boutsikos P., Matsaggoura-Sameli M., Riga M., Sainis P., Mitilinaiou-Karakozi E., Mainas K., Nikolaou K., Chatziparaskevas S., Ozai O., Vogiatzis G., Lilis L., Plaskas D., Chatzizisi S., Gianasmidis A., Petrovitsos E., Koykoyfikis G., Pittas A., Rovithis D., Ioannidis A., Dalamaga E., Kladas G., Afthonidis N., Pourou E., Katainidis S., Gavrilidou M., Kourtidou P., Tsamopoulos L., Kairis K., Arampatzi S., Basoukos C., Daskalakis K., Megianis V., Simintiridou D., Christoforidis T., Lafazanis G., Chatzioannidis L., Stephopoulos C., Karanika-Chandolia K., Teneketzi E., Mellidis C., Tsepelis P., Louspas C., Biternas M., Xionis T., Tsantilas D., Kosmanou M., Gougousis I., Chatzi F., Vassos A., Bitchavas S., Dalaveris E., Spiroulias G., Anastasopoulos I., Karlis D., Chiotis D., Christodoulou G., Arfanakis D., Psarogianni-Sinou V., Kokkinos S., Anifantis I., Alogogianni P., Michas A., Oikonomou A., Charalampous A., Papadopoulos P., Philipoiou Kotsoni M., Dragonas P., Laskari E., Tsiamtsiouri G., Kritsova-Avgerou V., Tiligadas T., Vrettos N., Vernardos N., Melessanakis M., Melidoniotis A., Liodakis E., Manousakis A., Galanakis C., Lampousakis I., Vyzoukakis E., Strimpouli G., Patramanis I., Chatziliadou D., Nioti K., Koynalakis D., Tserkis I., Androutsopoulou C., Liavvas C., and Karaoglanidou D.

Abstract

Background: This study assessed the diagnostic reliability of automated office blood pressure (OBP) measurements in treated hypertensive patients in primary care by evaluating the prevalence of white coat hypertension (WCH) and masked uncontrolled hypertension (MUCH) phenomena. Methods: Primary care physicians, nationwide in Greece, assessed consecutive hypertensive patients on stable treatment using OBP (1 visit, triplicate measurements) and home blood pressure (HBP) measurements (7 days, duplicate morning and evening measurements). All measurements were performed using validated automated devices with bluetooth capacity (Omron M7 Intelli-IT). Uncontrolled OBP was defined as ≥140/90 mmHg, and uncontrolled HBP was defined as ≥135/85 mmHg. Results: A total of 790 patients recruited by 135 doctors were analyzed (age: 64.5 ± 14.4 years, diabetics: 21.4%, smokers: 20.6%, and average number of antihypertensive drugs: 1.6 ± 0.8). OBP (137.5 ± 9.4/84.3 ± 7.7 mmHg, systolic/diastolic) was higher than HBP (130.6 ± 11.2/79.9 ± 8 mmHg; difference 6.9 ± 11.6/4.4 ± 7.6 mmHg, p < 0.001). WCH phenomenon (high OBP with low HBP) was observed in 22.7% of the patients, MUCH (low OBP with high HBP) in 15.8%, uncontrolled hypertension (high OBP with high HBP) in 29.9%, and controlled hypertension (low OBP with low HBP) in 31.6%. In multivariate logistic regression analysis, WCH was determined by stage-1 systolic hypertension (odds ratio [OR] 8.6, 95% confidence intervals [CI] 5.7, 13.1) and female gender (OR 1.6, 95% CI 1.1, 2.4), whereas MUCH was determined by high-normal systolic OBP (OR 6.2, 95% CI 3.8, 10.1) and male gender (OR 2.0, 95% CI 1.2, 3.1). Conclusions: In primary care, automated OBP measurements are misleading in approximately 40% of treated hypertensive patients. HBP monitoring is mandatory to avoid overtreatment of subjects with WCH phenomenon and prevent undertreatment and subsequent excess cardiovascular disease in MUCH.

Published
2020

4. Automated office blood pressure measurements in primary care are misleading in more than one third of treated hypertensives: The VALENTINE-Greece Home Blood Pressure Monitoring study

Author

Kollias, A., primary, Papadatos, S.S., additional, Dominiczak, A.F., additional, Parati, G., additional, Stergiou, G.S., additional, Demerouti, E., additional, Voulgaris, D., additional, Papadakis, I., additional, Karsanidis, A., additional, Triantafillou, A., additional, Garzonis, S., additional, Gourgoulis, G., additional, Trikalinou, A., additional, Karidas, P., additional, Savvalas, D., additional, Aggelopoulos, T., additional, Alevizos, A., additional, Moraiti, A., additional, Rosmarakis, E., additional, Chatzigeorgiou, G., additional, Antonakis, V., additional, Alexandropoulou-Tsirka, A., additional, Markaki, I., additional, Astrinakis, S., additional, Roilidis, V., additional, Polymeros, S., additional, Chariatis, E., additional, Panageas, V., additional, Kontoriga, A., additional, Patsioura, M., additional, Kleftaki-Manta, A., additional, Kalantaridou, A., additional, Kourouklis, S., additional, Papakonstantinos, G., additional, Barouni, P., additional, Grekidou, E., additional, Sklaveniti, A., additional, Kolovou, I., additional, Antoniadis, A., additional, Pelekanos, I., additional, Zervaki Drakou, N., additional, Tikka-Zoumpou, K., additional, Dalaklidou, V., additional, Menti, A., additional, Christofeli, A., additional, Androutsakos, T., additional, Doulgerakis, D., additional, Oikonomopoulou, I., additional, Moschos, M., additional, Koutras, D., additional, Skias, I., additional, Boutsikos, P., additional, Matsaggoura-Sameli, M., additional, Riga, M., additional, Sainis, P., additional, Mitilinaiou-Karakozi, E., additional, Mainas, K., additional, Nikolaou, K., additional, Chatziparaskevas, S., additional, Ozai, O., additional, Vogiatzis, G., additional, Lilis, L., additional, Plaskas, D., additional, Chatzizisi, S., additional, Gianasmidis, A., additional, Petrovitsos, E., additional, Koykoyfikis, G., additional, Pittas, A., additional, Rovithis, D., additional, Ioannidis, A., additional, Dalamaga, E., additional, Kladas, G., additional, Afthonidis, N., additional, Pourou, E., additional, Katainidis, S., additional, Gavrilidou, M., additional, Kourtidou, P., additional, Tsamopoulos, L., additional, Kairis, K., additional, Arampatzi, S., additional, Basoukos, C., additional, Daskalakis, K., additional, Megianis, V., additional, Simintiridou, D., additional, Christoforidis, T., additional, Lafazanis, G., additional, Chatzioannidis, L., additional, Stephopoulos, C., additional, Karanika-Chandolia, K., additional, Teneketzi, E., additional, Mellidis, C., additional, Tsepelis, P., additional, Louspas, C., additional, Biternas, M., additional, Xionis, T., additional, Tsantilas, D., additional, Kosmanou, M., additional, Gougousis, I., additional, Chatzi, F., additional, Vassos, A., additional, Bitchavas, S., additional, Dalaveris, E., additional, Spiroulias, G., additional, Anastasopoulos, I., additional, Karlis, D., additional, Chiotis, D., additional, Christodoulou, G., additional, Arfanakis, D., additional, Psarogianni-Sinou, V., additional, Kokkinos, S., additional, Anifantis, I., additional, Alogogianni, P., additional, Michas, A., additional, Oikonomou, A., additional, Charalampous, A., additional, Papadopoulos, P., additional, Philipoiou Kotsoni, M., additional, Dragonas, P., additional, Laskari, E., additional, Tsiamtsiouri, G., additional, Kritsova-Avgerou, V., additional, Tiligadas, T., additional, Vrettos, N., additional, Vernardos, N., additional, Melessanakis, M., additional, Melidoniotis, A., additional, Liodakis, E., additional, Manousakis, A., additional, Galanakis, C., additional, Lampousakis, I., additional, Vyzoukakis, E., additional, Strimpouli, G., additional, Patramanis, I., additional, Chatziliadou, D., additional, Nioti, K., additional, Koynalakis, D., additional, Tserkis, I., additional, Androutsopoulou, C., additional, Liavvas, C., additional, and Karaoglanidou, D., additional

Published
2020
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6. Myocardial inflammation in Duchenne Muscular Dystrophy as a precipitating factor for heart failure: a prospective study

Author

Kaklamanis Loukas, Polymeros Spyridon, Demerouti Eftichia, Kolovou Genovefa, Georgakopoulos Dimitris, Karanasios Evangelos, Papadopoulos George, Constandoulakis Pantelis, Spargias Kostas, Papavasiliou Antigoni, Mavrogeni Sophie, Magoutas Anastasios, Papadopoulou Evangelia, Markussis Vyron, and Cokkinos Dennis V

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background In patients with Duchenne Muscular Dystrophy (DMD), the absent or diminished dystrophin leads to progressive skeletal muscle and heart failure. We evaluated the role of myocardial inflammation as a precipitating factor in the development of heart failure in DMD. Methods 20 DMD patients (aged 15-18 yrs) and 20 age-matched healthy volunteers were studied and followed-up for 2 years. Evaluation of myocarditis with cardiovascular magnetic resonance imaging (CMR) was performed using STIR T2-weighted (T2W), T1-weighted (T1W) before and after contrast media and late enhanced images (LGE). Left ventricular volumes and ejection fraction were also calculated. Myocardial biopsy was performed in patients with positive CMR and immunohistologic and polymerase chain reaction (PCR) analysis was employed. Results In DMD patients, left ventricular end-diastolic volume (LVEDV) was not different compared to controls. Left ventricular end-systolic volume (LVESV) was higher (45.1 ± 6.6 vs. 37.3 ± 3.8 ml, p < 0.001) and left ventricular ejection fraction (LVEF) was lower (53.9 ± 2.1 vs. 63 ± 2.4%, p < 0.001). T2 heart/skeletal muscle ratio and early T1 ratio values in DMD patients presented no difference compared to controls. LGE areas were identified in six DMD patients. In four of them with CMR evidence of myocarditis, myocardial biopsy was performed. Active myocarditis was identified in one and healing myocarditis in three using immunohistology. All six patients with CMR evidence of myocarditis had a rapid deterioration of left ventricular function during the next year. Conclusions DMD patients with myocardial inflammation documented by CMR had a rigorous progression to heart failure.

Published
2010
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7. Poster session 6: Saturday 6 December 2014, 08:30-12:30 * Location: Poster area

Author

Goirigolzarri Artaza, J, Gallego Delgado, M, Jaimes Castellanos, CP, Cavero Gibanel, MA, Pastrana Ledesma, MA, Alonso Pulpon, LA, Gonzalez Mirelis, J, Al Ansi, R Z, Sokolovic, S, Cerin, G, Szychta, W, Popa, B A, Botezatu, D, Benea, D, Manganiello, S, Corlan, A, Jabour, A, Igual Munoz, B, Osaca Asensi, JOA, Andres La Huerta, AALH, Maceira Gonzalez, AMG, Estornell Erill, JEE, Cano Perez, OCP, Sancho-Tello, MJSTDC, Alonso Fernandez, PAF, Sepulveda Sanchez, PSS, Montero Argudo, AMA, Palombo, C, Morizzo, C, Baluci, M, Kozakova, M, Panajotu, A, Karady, J, Szeplaki, G, Horvath, T, Tarnoki, DL, Jermendy, AL, Geller, L, Merkely, B, Maurovich-Horvat, P, Group, MTA-SE "Lendület" Cardiovascular Imaging Research, Moustafa, S, Mookadam, F, Youssef, M, Zuhairy, H, Connelly, M, Prieur, T, Alvarez, N, Ashikhmin, Y, Drapkina, O, Boutsikou, M, Demerouti, E, Leontiadis, E, Petrou, E, Karatasakis, G, Kozakova, M, Morizzo, C, Bianchi, V, Marchi, B, Federico, G, Palombo, C, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Goto, M, Uejima, T, Itatani, K, Pedrizzetti, G, Mada, RO, Daraban, AM, Duchenne, J, Voigt, JU, Chiu, D Y Y, Green, D, Johnstone, L, Sinha, S, Kalra, PA, Abidin, N, Group, Salford Vascular Research, Sikora-Frac, M, Zaborska, B, Maciejewski, P, Bednarz, B, Budaj, A, Nemes, A, Sasi, V, Gavaller, H, Kalapos, A, Domsik, P, Katona, A, Szucsborus, T, Ungi, T, Forster, T, Ungi, I, Pluchinotta, FR, Arcidiacono, C, Saracino, A, Carminati, M, Bussadori, C, Dahlslett, T, Karlsen, S, Grenne, B, Sjoli, B, Bendz, B, Skulstad, H, Smiseth, OA, Edvardsen, T, Brunvand, H, Vereckei, A, Szelenyi, ZS, Szenasi, G, Santoro, C, Galderisi, M, Niglio, T, Santoro, M, Stabile, E, Rapacciuolo, A, Spinelli, L, De Simone, G, Esposito, G, Trimarco, B, Hubert, S, Jacquier, A, Fromonot, J, Resseguier, C, Tessier, A, Guieu, R, Renard, S, Haentjiens, J, Lavoute, C, Habib, G, Menting, M E, Koopman, LP, Mcghie, 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Figueiredo, L, and Cruz Ferreira, R

Abstract

Introduction: The increase of left auricular volume (LAV) is a robust cardiovascular event predictor. Despite that echochardiography is more often used, cardiac MRI is considered more accurate. Our objetives are to validate "fast" LAV measures by MRI vs the considered gold standard (GS) and to compare Echo and MRI in a wide spectrum of patients. Methods: In a non-selected popullation with MRI study previously realized, we measured LAV by biplane method (BPMR) and by area-length in 4 chamber view (ALMR) and compared them with biplane (BPe) and discs method (MDDe) in 4 chamber view in echo. To validate MRI measurements, we measured LAV in short axis slices (Simpson Method, SM) in a group of patients and considered it the GS. Results: 186 patients were included (mean age 51 ± 17 age; 123 male; 14 in AF) with clinical indication of cardiac MRI (Philips 1,5 T). In 24 patients SM was calculated. 29% of cardiac MRI were considered normal. Mean underlying pathologies were myocardiopathy (27%), Ischemic myocardiopathy (17%), myopericarditis (10%), prior to AF ablation (4%), valvular disease (6%) and miscellaneous (7%). Excellent correlation was obtained between "fast" MRI measurements and SM in MRI (SM vs BPMR interclass correlation coefficient ICC=0.965 and SM vs ALMR, ICC=0.958; P<0.05) with low interobserver variability (ICC=0.983 for SM; ICC=0.949 for BPMR; ICC=0.931 for ALMR). "Fast" measurements by MRI showed stadistical correlation between them (CCI=0.910) (Figure). Correlation between Echo and MRI measures was only moderate. (BPRM vs BPe CCI=0,469 mean difference -30 ml; ALMR vs MDDe ICC=0,456 mean difference -24 mL). Conclusions: ‘fast’ LAV measures by MRI are comparable with the MRI GS and also between them. Echo values seem to underestimate compared to MRI, so its use may not be suitable.

Published
2014
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8. The predictive value and evolution of N-terminal pro-B-type natriuretic peptide levels following transcutaneous aortic valve implantation.

Author

Spargias K, Polymeros S, Dimopoulos A, Manginas A, Pavlides G, Balanika M, Smirli A, Stavridis G, Dangas G, and Cokkinos DV

Subjects
Aged, 80 and over, Aortic Valve diagnostic imaging, Aortic Valve pathology, Chi-Square Distribution, Echocardiography, Female, Health Status Indicators, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases pathology, Heart Valve Prosthesis Implantation instrumentation, Humans, Male, Predictive Value of Tests, Prognosis, Time Factors, Aortic Valve surgery, Heart Valve Diseases surgery, Heart Valve Prosthesis Implantation methods, Natriuretic Peptide, Brain blood, Peptide Fragments blood
Abstract

Aims: We sought to define the predictive value and evolution of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels following transcutaneous aortic valve implantation (TAVI)., Methods and Results: We investigated 91 consecutive patients who underwent TAVI (59 transfemoral [TF], 32 transapical [TA]) in our institution. The balloon-expandable valve was implanted in 75 and the self-expanding in 16 patients. The baseline (within 48 hours prior to procedure), early (24-74 hours), and late (3-12 months) postprocedural NT-proBNP levels were determined. The mortality status of all patients was ascertained as of September 2010. The 30-day and 1.3(mean)-year mortality was 3% and 12% (2%, 9% in the TF and 6%, 19% in the TA group). Increased baseline (χ(2) = 5.9, P = 0.016) and early (χ(2) = 4.9, P = 0.028) NT-proBNP levels were predictive of mortality. All decrements of the NT-proBNP levels in the TF patients were significant (baseline 4,984 ± 8,106 vs. early 3,912 ± 6,551 pg/mL, P = 0.016; late 633 ± 606 pg/mL, P = 0.003). In contrast, there was a trend for the early levels to increase in the TA patients (6,423 ± 8,897 vs. 8,100 ± 10,178 pg/mL, P = 0.090), and a significant decline in the late levels as compared to baseline (1,704 ± 3,417 pg/mL, P = 0.005)., Conclusion: NT-proBNP levels are predictive of mortality following TAVI. There is a differential early evolution of their levels between the TF and TA patients and a significant decline later in both groups. , (©2011, Wiley Periodicals, Inc.)

Published
2011
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9. Transcatheter aortic valve implantation: first Greek experience.

Author

Spargias K, Manginas A, Pavlides G, Khoury M, Stavridis G, Rellia P, Smirli A, Thanopoulos A, Balanika M, Polymeros S, Thomopoulou S, Athanassopoulos G, Karatasakis G, Mastorakou R, Lacoumenta S, Michalis A, Alivizatos P, and Cokkinos D

Subjects
Aged, Aged, 80 and over, Aortic Valve Stenosis surgery, Cardiac Catheterization, Coronary Angiography, Female, Humans, Length of Stay, Male, Prognosis, Heart Valve Prosthesis Implantation methods
Abstract

Introduction: Percutaneous aortic valve replacement represents an alternative to conventional open-heart surgery for selected high-risk patients without the need for sternotomy, aortotomy, or cardiopulmonary bypass. We present the first Greek series of transcatheter prosthetic aortic valve implantation procedures, performed in our centre., Methods: All 12 patients (age 81 +/- 5 years) had severe, symptomatic, calcific aortic stenosis and were judged not to have a reasonable surgical option by a medical team including experienced cardiac surgeons. The patients' mean logistic EuroSCORE was 34 +/- 15% (min 11%, max 61%). Eight (8) of them underwent transfemoral (SAPIEN, Edwards 23 mm valve in 7 and 26 mm in 1 patient) and 4 transapical (26 mm in 2 and 23 mm in 2 patients) prosthetic aortic valve implantation, all in the cardiac catheterisation laboratory under general anaesthesia., Results: The procedural, in-hospital and 2-month (mean follow up 50 days, min 17, max 122 days) mortality was 0%. The length of hospital stay was 8 +/- 2 days (min 5, max 12 days). The aortic valve area increased from 0.64 +/- 0.14 cm2 to 1.83 +/- 0.14 cm2 and the mean pressure gradient decreased from 57 +/- 23 mmHg to 10 +/- 3 mmHg post-implantation (p<0.001 for both). The patients' mean NYHA functional status improved from 2.8 +/- 0.7 to 1.3 +/- 0.5 at follow-up (p<0.001)., Conclusions: Our initial experience with transcatheter prosthetic aortic valve implantation demonstrates that it can be performed safely and with excellent short and mid-term clinical outcomes.

Published
2008

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