269 results on '"Polyak, Steven W"'
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2. Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance
3. Structural optimization of natural product nordihydroguaretic acid to discover novel analogues as AcrB inhibitors
4. Cofactors and Coenzymes | Biotin
5. A template guided approach to generating cell permeable inhibitors of Staphylococcus aureus biotin protein ligase
6. Fortuitous In Vitro Compound Degradation Produces a Tractable Hit against Mycobacterium tuberculosis Dethiobiotin Synthetase: A Cautionary Tale of What Goes In Does Not Always Come Out
7. Measuring Small Molecule Binding to Escherichia coli AcrB by Surface Plasmon Resonance
8. Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin
9. Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6
10. Native mass spectrometry identifies an alternative DNA-binding pathway for BirA from Staphylococcus aureus
11. Structural Study of Potent Triazole-Based Inhibitors of Staphylococcus aureus Biotin Protein Ligase
12. Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase
13. Role of intracellular energy metabolism in Mn(Ⅱ) removal by the novel bacterium Stenotrophomonas sp. MNB17
14. A New 1,2,3-Triazole Scaffold with Improved Potency against Staphylococcus aureus Biotin Protein Ligase
15. Cinnamaldehyde derivatives act as antimicrobial agents against Acinetobacter baumannii through the inhibition of cell division
16. The Role of Biotin in Bacterial Physiology and Virulence: a Novel Antibiotic Target forMycobacterium tuberculosis
17. Differential growth inhibition, cell cycle arrest and apoptosis of MCF-7 and MDA-MB-231 cells to holocarboxylase synthetase suppression
18. Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase (MtDTBS): Toward Next-Generation Antituberculosis Agents
19. Actinonin resistance of pathogenic Vibrio anguillarum in aquaculture
20. A novel molecular mechanism to explain biotin-unresponsive holocarboxylase synthetase deficiency
21. Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention
22. Molecular cloning and characterization of a new cold-active esterase from a deep-sea metagenomic library
23. Escherichia coli biotin protein ligase: characterization and development of a high-throughput assay
24. Microbial biotin protein ligases aid in understanding holocarboxylase synthetase deficiency
25. A hypoxia-activated antibacterial prodrug
26. Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus
27. New Isocoumarin Analogues from the Marine-Derived Fungus Paraphoma sp. CUGBMF180003
28. Cinnamaldehyde derivatives act as antimicrobial agents against Acinetobacter baumannii through the inhibition of cell division.
29. Antimicrobial Action and Reversal of Resistance in MRSA by Difluorobenzamide Derivatives Targeted at FtsZ
30. Design and synthesis of novel 4-substituted quinazoline-2-carboxamide derivatives targeting AcrB to reverse the bacterial multidrug resistance
31. Probing the stability of the disulfide radical intermediate of thioredoxin using direct electrochemistry
32. Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: An antibiotic target
33. Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance
34. Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid‐binding globulin
35. Biochemical characterisation of class III biotin protein ligases from Botrytis cinerea and Zymoseptoria tritici
36. Overexpression of Holocarboxylase Synthetase Predicts Lymph Node Metastasis and Unfavorable Prognosis in Breast Cancer
37. Short Photoswitchable Antibacterial Peptides
38. Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase
39. Biotin
40. Reduced Half-life of Holocarboxylase Synthetase from Patients with Severe Multiple Carboxylase Deficiency
41. Probing the stability of the disulfide radical intermediate of thioredoxin using direct electrochemistry
42. Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads
43. Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
44. Photopharmacological Control of Cyclic Antimicrobial Peptides
45. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
46. Precipitant–ligand exchange technique reveals the ADP binding mode inMycobacterium tuberculosisdethiobiotin synthetase
47. Biosynthetically Guided Structure–Activity Relationship Studies of Merochlorin A, an Antibiotic Marine Natural Product
48. Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus
49. Mechanisms Governing Precise Protein Biotinylation
50. Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase
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