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16 results on '"Polveroni, Thomas M."'

7. List of contributors

Author

Abdellatif, Bahaa, Adeleye, Olufunmilola, Adenwalla, Ammar, Allen, Christopher, Anderson, Scott T., Antezana, Luis, Arya, Namrata, Ashraf, Asad M., Badejo, Megan A., Baez, Catalina, Bass, Elisa, Beck, Kelsey, Bindi, Victoria E., Bisen, Shivani Singh, Cameron Greene, Justin, Campany, Megan, Campbell, Leigh, Choueka, Jack, Dean, Michael C., Deshpande, Anagha, Diaz, Michael, Elahi, Muhammad Ali, Gerges, Paul, Ghaith, Summer, Golub, Ivan J., Gonzalez, Viviana, Guirgis, Mirian, Hao, Kevin Anthony, Harrison, Noah James, Hijazin, Amanda, Hla, Diana A., Holm, Skye, Hones, Keegan M., Hwang, James, Islam, Fatima Z., Islam, Muhammad S., Jenkins, Anna S., Jin, Mauricio Franco, Khalil, Yusuf, Kirollos, Monica, Lee, Yeonsoo Sara, Lin, Keldon Kai, Malik, Sara, Manzur, Karen, Martinez, Frank, Miller, Matthew, Molla, Vadim, Moore, Michael Lane, Muro-Cardenas, Jose, Murphy, Sierra, Nelson, Benjamin Alan, Newman, Hana R., O'Neill, Stephen, Ogbaudu, Ewoma, Ohaya, Theresa C., Osborne, Andrew, Patel, Shyam, Pereira, Daniel E., Pollock, Jordan R., Polveroni, Thomas M., Quintero-Martinez, Juan Andres, Ragheb, Jonathan, Ragheb, Daniel, Razi, Afshin E., Roche, Martin W., Rosenow, Christian S., Saba, Dina, Saleeb, Andrew, Sequeira, Lynette M., Sequeira, Sean, Shigley, Christian, Skjaerlund, Jonathan, Smith, Jacob F., Smith, Julianna, Soriano, David F., Thakkar, Raashi, Thakkar, Khushi, Vakharia, Ajit M., Vakharia, Rushabh M., Vialonga, Mason, Voleti, Sandeep Sai, Weisberg, Miriam D., Weston, Gabriella F., Yacoub, Joseph, Yacoub, Michael, Yacoub, David, Yacoub, Benjamin, Yacoub, Sarah, and Yoon, Richard S.

Published
2024
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10. Formative Feedback with In-Class Question Bank Utilization Improves Resident Satisfaction with General Surgery Didactics

Author

Hammond,Jacob B, Sheaffer,William W, Teven,Chad M, Wasif,Nabil, Mishra,Nitin, Davila,Victor J, Casey,William J, Polveroni,Thomas M, Moore,Leah W, Smith,Anthony A, Hammond,Jacob B, Sheaffer,William W, Teven,Chad M, Wasif,Nabil, Mishra,Nitin, Davila,Victor J, Casey,William J, Polveroni,Thomas M, Moore,Leah W, and Smith,Anthony A

Abstract

Jacob B Hammond, William W Sheaffer, Chad M Teven, Nabil Wasif, Nitin Mishra, Victor J Davila, William J Casey, Thomas M Polveroni, Leah W Moore, Anthony A Smith Department of Surgery, Mayo Clinic, Phoenix, AZ, USACorrespondence: Anthony A Smith Email smith.anthony@mayo.eduBackground: Formative feedback provides low-stakes opportunities for educational improvement. To enrich our basic science didactics, formative feedback measures were incorporated into our didactics using mobile devices.Materials and Methods: Lecture changes included institutional paid access to a commercial question bank, a 5-item in-class pre-didactic quiz curated from the question bank and taken on the resident’s mobile device, and group discussion of quiz topics. An anonymous survey was sent to participating residents.Results: Overall response rate was 71% among residents. All reported that the new lecture format was a valuable addition to the basic science curriculum (100% Agree/Strongly Agree), and formative assessments provided valuable feedback about the progress of their learning (Strongly Agree = 42%, Agree =58%). All residents reported that in-class use of their mobile device for quizzes was convenient, with majority (84%) preferring it over paper printouts. Residents were more motivated to study before lecture (Strongly Agree = 42%, Agree =42%), with majority also reporting the new format helped identify weaknesses in their knowledgebase (Strongly Agree = 58%, Agree =33%). While majority of residents agreed that quizzes motivated them to study more after lecture, a large portion disagreed (42%). Majority of senior residents reported that the process of composing quizzes prior to lecture enriched their own learning (57%) and helped them find gaps in their knowledge (71%).Conclusion: Incorporating a commercial question bank within didactics gives general surgery residents formative feedback and encourages learning outside the classroom, leading to improved satisfaction with basic scienc

Published
2021

12. Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

Author

Seabright, Gemma E., primary, Cottrell, Christopher A., additional, van Gils, Marit J., additional, D'addabbo, Alessio, additional, Harvey, David J., additional, Behrens, Anna-Janina, additional, Allen, Joel D., additional, Watanabe, Yasunori, additional, Scaringi, Nicole, additional, Polveroni, Thomas M., additional, Maker, Allison, additional, Vasiljevic, Snezana, additional, de Val, Natalia, additional, Sanders, Rogier W., additional, Ward, Andrew B., additional, and Crispin, Max, additional

Published
2020
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13. Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits

Author

Yang, Yuhe R., primary, McCoy, Laura E., additional, van Gils, Marit J., additional, Andrabi, Raiees, additional, Turner, Hannah L., additional, Yuan, Meng, additional, Cottrell, Christopher A., additional, Ozorowski, Gabriel, additional, Voss, James, additional, Pauthner, Matthias, additional, Polveroni, Thomas M., additional, Messmer, Terrence, additional, Wilson, Ian A., additional, Sanders, Rogier W., additional, Burton, Dennis R., additional, and Ward, Andrew B., additional

Published
2020
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14. Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

Author

Yang, Yuhe R., primary, McCoy, Laura E., additional, van Gils, Marit J., additional, Andrabi, Raiees, additional, Turner, Hannah L., additional, Yuan, Meng, additional, Cottrell, Christopher A., additional, Ozorowski, Gabriel, additional, Voss, James, additional, Pauthner, Matthias, additional, Polveroni, Thomas M., additional, Messmer, Terrence, additional, Wilson, Ian A., additional, Sanders, Rogier W., additional, Burton, Dennis R., additional, and Ward, Andrew B., additional

Published
2019
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16. Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits.

Author

Yang, Yuhe R., McCoy, Laura E., van Gils, Marit J., Andrabi, Raiees, Turner, Hannah L., Yuan, Meng, Cottrell, Christopher A., Ozorowski, Gabriel, Voss, James, Pauthner, Matthias, Polveroni, Thomas M., Messmer, Terrence, Wilson, Ian A., Sanders, Rogier W., Burton, Dennis R., and Ward, Andrew B.

Subjects
*ANTIBODY formation, *HIV antibodies, *RABBITS, *AMINO acids, *IMMUNOGLOBULINS
Abstract

Extensive studies with subtype A BG505-derived HIV Env immunogens have revealed that the dominant autologous neutralizing epitope in rabbits is located in an exposed region of the heavily glycosylated trimer that lacks potential N-linked glycosylation sites at positions 230, 241, and 289. The Env derived from B41, a subtype B virus, shares a glycan hole centered on positions 230 and 289. To test whether broader neutralization to the common glycan hole can be achieved, we immunized rabbits with B41 SOSIP alone, as well as B41 and BG505 co-immunization. We isolated autologous neutralizing antibodies (nAbs) and described their structure in complex with the B41 Env. Our data suggest that distinct autologous nAb lineages are induced by BG505 and B41 immunogens, even when both were administered together. In contrast to previously described BG505 glycan hole antibodies, the B41-specific nAbs accommodate the >97% conserved N241 glycan, which is present in B41. Single particle cryo-electron microscopy studies confirmed that B41 and BG505-specific nAbs bind to overlapping glycan hole epitopes. We then used our high-resolution data to guide mutations in the BG505 glycan hole epitope in an attempt to broaden the reactivity of a B41-specific nAb, but only recovered partial binding. Our data demonstrate that lack of cross- reactivity in glycan hole antibodies is due to amino acid differences within the epitope and our attempts to rationally design cross-reactive trimers resulted in only limited success. Thus, even for the immunodominant glycan hole shared between BG505 and B41 the prospect of designing prime-boost immunogens remains difficult. [ABSTRACT FROM AUTHOR]

Published
2020
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