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344 results on '"Polonara, Gabriele"'

9. Cerebral Aneurysms and Arteriovenous Malformation: Preliminary Experience with the Use of Near-Infrared Fluorescence Imaging Applied to Endoscopy.

Author

Aiudi, Denis, Iacoangeli, Alessio, Mattioli, Andrea, Raggi, Alessio, Dobran, Mauro, Polonara, Gabriele, Gigli, Riccardo, Iacoangeli, Maurizio, and Gladi, Maurizio

Subjects
CEREBRAL arteriovenous malformations, INDOCYANINE green, CEREBRAL circulation, ARTERIOVENOUS fistula, INTRACRANIAL aneurysms
Abstract

Background/Objectives: Indocyanine green video angiography, integrated into the operative microscope, is frequently used in cerebrovascular surgery. This technology is often preferred, for cost or availability, to Doppler or intraoperative DSA (digital subtraction angiography). With the same assumption it was possible, in our preliminary experience, to partially vicariate the aforementioned devices using the SPY mode of the Stryker endoscope; it allowed the visualization of fluorescence in high definition. Methods: A retrospective analysis was conducted on a series of five patients suffering from cerebral aneurysm or AVM (arteriovenous malformation) who underwent, during the last year, surgical treatment with the aid of the microscope supported by the Stryker endoscope in the SPY mode for the visualization of the fluorescence emitted by indocyanine green. Results: All aneurysms were completely excluded from the cerebrovascular circulation in the absence of residues in the collar and occlusion of adjacent vessels; the complete removal of the nidus in all the AVMs was achieved with no residues. Conclusions: The intraoperative use of indocyanine green was a safe, rapid, and effective technique within a preliminary case study of "regular—not giant" aneurysms and superficially located AVM. The endoscopic technique in the SPY mode has allowed to partially vicariate the use of Doppler, intraoperative angiography, and integrated microscope video angiography. For these purposes, we propose, in selected cases, the support of the endoscope in the SPY mode during the microsurgical procedure in order to visualize the green fluorescence of indocyanine. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Point-Of-Care low-field MRI in acute Stroke (POCS): protocol for a multicentric prospective open-label study evaluating diagnostic accuracy

Author

Foschi, Matteo, primary, Galante, Angelo, additional, Ornello, Raffaele, additional, Necozione, Stefano, additional, Marini, Carmine, additional, Muselli, Mario, additional, Achard, Paola Olimpia, additional, Fratocchi, Luciano, additional, Vinci, Sergio Lucio, additional, Cavallaro, Marco, additional, Silvestrini, Mauro, additional, Polonara, Gabriele, additional, Marcheselli, Simona, additional, Straffi, Laura, additional, Colasurdo, Marco, additional, Sorrentino, Luca, additional, Franconi, Enrico, additional, Alecci, Marcello, additional, Caulo, Massimo, additional, and Sacco, Simona, additional

Published
2024
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21. The ATTRACT study: screening for the early identification of axial psoriatic arthritis in a cohort of Italian psoriatic patients.

Author

Gentiloni, Michele Maria Luchetti, Paci, Valentino, Cimaroli, Ilaria, Agostinelli, Alice, Giannoni, Melania, Campanati, Anna, Diotallevi, Federico, Carotti, Marina, Sessa, Francesco, Sordillo, Raffaella, Macchini, Cristina, Fiorini, Federico, Massaccesi, Leonardo, Ciferri, Monia, Gigli, Marco, Marconi, Valentina, Perini, Lucia, Marani, Andrea, Giovagnoni, Andrea, and Polonara, Gabriele

Subjects
CROSS-sectional method, PSORIATIC arthritis, DISEASE duration, ANKYLOSIS, QUESTIONNAIRES, SPONDYLOARTHROPATHIES, MEDICAL screening, EARLY diagnosis, DERMATOLOGISTS, INFLAMMATION, BACKACHE, SACROILIAC joint, C-reactive protein, EVALUATION, SYMPTOMS
Abstract

Objective There is growing interest in the early identification of patients with axial PsA (axPsA). We aimed to evaluate whether a dermatology-based screening strategy could help to identify axPsA patients. Methods The dermatologist-centred screening (DCS) questionnaire was administrated by dermatologists to consecutive patients fulfilling the inclusion criteria [(i) age ≥18 years and (ii) clinical diagnosis of psoriasis made by a dermatologist] to identify patients eligible (affirmative answers 1–3c of the DCS) for rheumatological evaluation. Clinical, laboratory, genetic and imaging data were collected from all referred patients. Results Among the 365 patients screened, 265 fulfilled the inclusion criteria and 124/265 (46.8%) were eligible for rheumatological referral. Diagnosis of axPsA, with or without peripheral PsA (pPsA), was made in 36/124 (29.0%) patients; pPsA without axial involvement was found in 21/124 (16.9%) patients. Back pain at screening was recorded in 174 (66%) patients, with 158 (60%) reporting a back pain duration longer than 3 months and 140 (53%) reporting back pain onset before the age of 45 years. Active inflammatory and/or structural post-inflammatory changes in the sacroiliac joints and/or spine were observed in all axPsA patients. Patients with PsA showed a numerically longer duration of back pain and higher CRP levels in comparison with patients with psoriasis without PsA. Conclusion The DCS tool proved to be a valuable screening strategy for detecting and characterizing patients with axPsA in a real-life cohort of psoriasis patients in a dermatological setting and helped to identify a substantial number of patients affected by undiagnosed pPsA. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Tumor Progression : Morphofunctional MR Follow-up in Glioblastoma Multiforme

Author

Polonara, Gabriele, Alvaro, Lorenzo, Sessa, Francesco, Scarabino, Tommaso, editor, Caranci, Ferdinando, Cooperation partner, Carriero, Alessandro, Cooperation partner, Muto, Mario, Cooperation partner, Pollice, Saverio, Cooperation partner, Polonara, Gabriele, Cooperation partner, Popolizio, Teresa, Cooperation partner, Stecco, Alessandro, Cooperation partner, and Tartaro, Armando, Cooperation partner

Published
2012
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35. Stable Disease : Morphofunctional MR Follow-up in Glioblastoma Multiforme

Author

Polonara, Gabriele, Alvaro, Lorenzo, Herber, Nathalie, Scarabino, Tommaso, editor, Caranci, Ferdinando, Cooperation partner, Carriero, Alessandro, Cooperation partner, Muto, Mario, Cooperation partner, Pollice, Saverio, Cooperation partner, Polonara, Gabriele, Cooperation partner, Popolizio, Teresa, Cooperation partner, Stecco, Alessandro, Cooperation partner, and Tartaro, Armando, Cooperation partner

Published
2012
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41. Pediatric Moyamoya Disease and Syndrome in Italy: A Multicenter Cohort

Author

Po', Chiara, Nosadini, Margherita, Zedde, Marialuisa, Pascarella, Rosario, Mirone, Giuseppe, Cicala, Domenico, Rosati, Anna, Cosi, Alessandra, Toldo, Irene, Colombatti, Raffaella, Martelli, Paola, Iodice, Alessandro, Accorsi, Patrizia, Giordano, Lucio, Savasta, Salvatore, Foiadelli, Thomas, Sanfilippo, Giuseppina, Lafe, Elvis, Thyrion, Federico Zappoli, Polonara, Gabriele, Campa, Serena, Raviglione, Federico, Scelsa, Barbara, Bova, Stefania Maria, Greco, Filippo, Cordelli, Duccio Maria, Cirillo, Luigi, Toni, Francesco, Baro, Valentina, Causin, Francesco, Frigo, Anna Chiara, Suppiej, Agnese, Sainati, Laura, Azzolina, Danila, Agostini, Manuela, Cesaroni, Elisabetta, De Carlo, Luigi, Di Rosa, Gabriella, Esposito, Giacomo, Grazian, Luisa, Morini, Giovanna, Nicita, Francesco, Operto, Francesca Felicia, Pruna, Dario, Ragazzi, Paola, Rollo, Massimo, Spalice, Alberto, Striano, Pasquale, Skabar, Aldo, Lanterna, Luigi Alberto, Carai, Andrea, Marras, Carlo Efisio, Manara, Renzo, Sartori, Stefano, Po', Chiara, Nosadini, Margherita, Zedde, Marialuisa, Pascarella, Rosario, Mirone, Giuseppe, Cicala, Domenico, Rosati, Anna, Cosi, Alessandra, Toldo, Irene, Colombatti, Raffaella, Martelli, Paola, Iodice, Alessandro, Accorsi, Patrizia, Giordano, Lucio, Savasta, Salvatore, Foiadelli, Thoma, Sanfilippo, Giuseppina, Lafe, Elvi, Thyrion, Federico Zappoli, Polonara, Gabriele, Campa, Serena, Raviglione, Federico, Scelsa, Barbara, Bova, Stefania Maria, Greco, Filippo, Cordelli, Duccio Maria, Cirillo, Luigi, Toni, Francesco, Baro, Valentina, Causin, Francesco, Frigo, Anna Chiara, Suppiej, Agnese, Sainati, Laura, Azzolina, Danila, Agostini, Manuela, Cesaroni, Elisabetta, De Carlo, Luigi, Di Rosa, Gabriella, Esposito, Giacomo, Grazian, Luisa, Morini, Giovanna, Nicita, Francesco, Operto, Francesca Felicia, Pruna, Dario, Ragazzi, Paola, Rollo, Massimo, Spalice, Alberto, Striano, Pasquale, Skabar, Aldo, Lanterna, Luigi Alberto, Carai, Andrea, Marras, Carlo Efisio, Manara, Renzo, and Sartori, Stefano

Subjects
arteriopathy, indirect revascularization, aspirin, moyamoya, cerebrovascular event, transient ischemic attack, Pediatrics, Perinatology and Child Health, cerebrovascular events, headache, stroke, NO
Abstract

BackgroundMoyamoya is a rare progressive cerebral arteriopathy, occurring as an isolated phenomenon (moyamoya disease, MMD) or associated with other conditions (moyamoya syndrome, MMS), responsible for 6–10% of all childhood strokes and transient ischemic attacks (TIAs).MethodsWe conducted a retrospective multicenter study on pediatric-onset MMD/MMS in Italy in order to characterize disease presentation, course, management, neuroradiology, and outcome in a European country.ResultsA total of 65 patients (34/65 women) with MMD (27/65) or MMS (38/65) were included. About 18% (12/65) of patients were asymptomatic and diagnosed incidentally during investigations performed for an underlying condition (incMMS), whereas 82% (53/65) of patients with MMD or MMS were diagnosed due to the presence of neurological symptoms (symptMMD/MMS). Of these latter, before diagnosis, 66% (43/65) of patients suffered from cerebrovascular events with or without other manifestations (ischemic stroke 42%, 27/65; TIA 32%, 21/65; and no hemorrhagic strokes), 18% (12/65) of them reported headache (in 4/12 headache was not associated with any other manifestation), and 26% (17/65) of them experienced multiple phenotypes (≥2 among: stroke/TIA/seizures/headache/others). Neuroradiology disclosed ≥1 ischemic lesion in 67% (39/58) of patients and posterior circulation involvement in 51% (30/58) of them. About 73% (47/64) of patients underwent surgery, and 69% (45/65) of them received aspirin, but after diagnosis, further stroke events occurred in 20% (12/61) of them, including operated patients (11%, 5/47). Between symptom onset and last follow-up, the overall patient/year incidence of stroke was 10.26% (IC 95% 7.58–13.88%). At last follow-up (median 4 years after diagnosis, range 0.5–15), 43% (26/61) of patients had motor deficits, 31% (19/61) of them had intellectual disability, 13% (8/61) of them had epilepsy, 11% (7/61) of them had behavioral problems, and 25% (13/52) of them had mRS > 2. The proportion of final mRS > 2 was significantly higher in patients with symptMMD/MMS than in patients with incMMS (p = 0.021). Onset age p = 0.0010 and p = 0.0071, respectively) and mRS > 2 at follow-up (p = 0.0106 and p = 0.0009, respectively).ConclusionsMoyamoya is a severe condition that may affect young children and frequently cause cerebrovascular events throughout the disease course, but may also manifest with multiple and non-cerebrovascular clinical phenotypes including headache (isolated or associated with other manifestations), seizures, and movement disorder. Younger onset age and stroke before diagnosis may associate with increased risk of worse outcome (final mRS > 2).

Published
2022

44. Pediatric Moyamoya Disease and Syndrome in Italy: A Multicenter Cohort

Author

Po', Chiara, primary, Nosadini, Margherita, additional, Zedde, Marialuisa, additional, Pascarella, Rosario, additional, Mirone, Giuseppe, additional, Cicala, Domenico, additional, Rosati, Anna, additional, Cosi, Alessandra, additional, Toldo, Irene, additional, Colombatti, Raffaella, additional, Martelli, Paola, additional, Iodice, Alessandro, additional, Accorsi, Patrizia, additional, Giordano, Lucio, additional, Savasta, Salvatore, additional, Foiadelli, Thomas, additional, Sanfilippo, Giuseppina, additional, Lafe, Elvis, additional, Thyrion, Federico Zappoli, additional, Polonara, Gabriele, additional, Campa, Serena, additional, Raviglione, Federico, additional, Scelsa, Barbara, additional, Bova, Stefania Maria, additional, Greco, Filippo, additional, Cordelli, Duccio Maria, additional, Cirillo, Luigi, additional, Toni, Francesco, additional, Baro, Valentina, additional, Causin, Francesco, additional, Frigo, Anna Chiara, additional, Suppiej, Agnese, additional, Sainati, Laura, additional, Azzolina, Danila, additional, Agostini, Manuela, additional, Cesaroni, Elisabetta, additional, De Carlo, Luigi, additional, Di Rosa, Gabriella, additional, Esposito, Giacomo, additional, Grazian, Luisa, additional, Morini, Giovanna, additional, Nicita, Francesco, additional, Operto, Francesca Felicia, additional, Pruna, Dario, additional, Ragazzi, Paola, additional, Rollo, Massimo, additional, Spalice, Alberto, additional, Striano, Pasquale, additional, Skabar, Aldo, additional, Lanterna, Luigi Alberto, additional, Carai, Andrea, additional, Marras, Carlo Efisio, additional, Manara, Renzo, additional, and Sartori, Stefano, additional

Published
2022
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