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326 results on '"Polo G"'

4. Niemann-Pick Type C-2 Disease: Identification by Analysis of Plasma Cholestane-3β,5α,6β-Triol and Further Insight into the Clinical Phenotype

Author

Reunert, J., Lotz-Havla, A. S., Polo, G., Kannenberg, F., Fobker, M., Griese, M., Mengel, E., Muntau, A. C., Schnabel, P., Sommerburg, O., Borggraefe, I., Dardis, A., Burlina, A. P., Mall, M. A., Ciana, G., Bembi, B., Burlina, A. B., Marquardt, T., Zschocke, Johannes, Editor-in-chief, Baumgartner, Matthias, editor, Morava, Eva, editor, Patterson, Marc, editor, Rahman, Shamima, editor, and Peters, Verena, editor

Published
2015
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9. The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis

Author

Santomartino, R, Camponeschi, I, Polo, G, Immesi, A, Rinaldi, T, Mazzoni, C, Brambilla, L, Bianchi, M, Santomartino R., Camponeschi I., Polo G., Immesi A., Rinaldi T., Mazzoni C., Brambilla L., Bianchi M. M., Santomartino, R, Camponeschi, I, Polo, G, Immesi, A, Rinaldi, T, Mazzoni, C, Brambilla, L, Bianchi, M, Santomartino R., Camponeschi I., Polo G., Immesi A., Rinaldi T., Mazzoni C., Brambilla L., and Bianchi M. M.

Abstract

Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes. The response and/or adaptation to hypoxia and other changing environmental conditions can influence the properties and functions of membranes by modifying lipid composition. In the yeast Kluyveromyces lactis, the KlMga2 gene is a hypoxic regulatory factor for lipid biosynthesis-fatty acids and sterols- A nd is also involved in glucose signaling, glucose catabolism and is generally important for cellular fitness. In this work we show that, in addition to the above defects, the absence of the KlMGA2 gene caused increased resistance to oxidative stress and extended lifespan of the yeast, associated with increased expression levels of catalase and SOD genes. We propose that KlMga2 might also act as a mediator of the oxidative stress response/adaptation, thus revealing connections among hypoxia, glucose signaling, fatty acid biosynthesis and ROS metabolism in K. lactis.

Published
2019

18. Family-centred care for children and young people with cerebral palsy: results from an Italian multicenter observational study

Author

Molinaro, A, Fedrizzi, E, Calza, S, Pagliano, E, Galli, J, Fazzi, E, Trabacca, A, Vespino, T, Gallino, F, Villani, A, Picciolini, O, Cozzaglio, M, Baranello, G, Zambonin, F, Daniela, F, Mandalari, P, Mirabile, L, Nacinovich, R, Broggi, F, De Polo, G, Da Ruos, F, Cazzagon, M, Godio, M, Piantoni, C, Dusi, E, Marzaroli, M, Fusari, D, Arisi, D, Magri, S, Landi, N, Roberti, L, Signorini, S, Luparia, A, Sabbadini, M, Riccioli, N, Turconi, A, Molteni, F, Marcelli, M, Di Brina, C, Molinaro A., Fedrizzi E., Calza S., Pagliano E., Galli J., Fazzi E., Trabacca A., Vespino T., Gallino F., Villani A., Picciolini O., Cozzaglio M., Baranello G., Zambonin F., Daniela F., Mandalari P., Mirabile L., Nacinovich R., Broggi F., De Polo G., Da Ruos F., Cazzagon M., Godio M., Piantoni C., Dusi E., Marzaroli M., Fusari D., Arisi D., Magri S., Landi N., Roberti L., Signorini S., Luparia A., Sabbadini M., Riccioli N., Turconi A. C., Molteni F., Marcelli M., Di Brina C., Molinaro, A, Fedrizzi, E, Calza, S, Pagliano, E, Galli, J, Fazzi, E, Trabacca, A, Vespino, T, Gallino, F, Villani, A, Picciolini, O, Cozzaglio, M, Baranello, G, Zambonin, F, Daniela, F, Mandalari, P, Mirabile, L, Nacinovich, R, Broggi, F, De Polo, G, Da Ruos, F, Cazzagon, M, Godio, M, Piantoni, C, Dusi, E, Marzaroli, M, Fusari, D, Arisi, D, Magri, S, Landi, N, Roberti, L, Signorini, S, Luparia, A, Sabbadini, M, Riccioli, N, Turconi, A, Molteni, F, Marcelli, M, Di Brina, C, Molinaro A., Fedrizzi E., Calza S., Pagliano E., Galli J., Fazzi E., Trabacca A., Vespino T., Gallino F., Villani A., Picciolini O., Cozzaglio M., Baranello G., Zambonin F., Daniela F., Mandalari P., Mirabile L., Nacinovich R., Broggi F., De Polo G., Da Ruos F., Cazzagon M., Godio M., Piantoni C., Dusi E., Marzaroli M., Fusari D., Arisi D., Magri S., Landi N., Roberti L., Signorini S., Luparia A., Sabbadini M., Riccioli N., Turconi A. C., Molteni F., Marcelli M., and Di Brina C.

Abstract

Background: Family-centred care (FCC) is recognized as the model of best practice for the provision of services for children who have physical disabilities and their families. Objective: To assess the overall perception of FCC provided in an Italian network of 17 rehabilitation services, as perceived by parents of children with cerebral palsy and professionals, and to explore whether children, families, service providers and service-related characteristics influence parent satisfaction regarding service provision in an FCC practice. Methods: The Measure of Processes of Care (MPOC-20) for parents/caregivers and the Measure of Processes of Care for Service Providers (MPOC-SP) for healthcare providers were used. For the purposes of the study, an ad hoc information form was developed to collect information concerning children, families, service providers and services. Results: A total of 382 parents/caregivers and 269 healthcare providers completed the MPOC questionnaires. Parents and service providers both identified the domains for enabling partnerships and interpersonal sensitivity as a strength, while the domain relating to general information was always scored the lowest. An advanced maternal age, being a single parent, being unemployed and having lower socio-economic status were factors identified as individually predictive of lower FCC scores on the MPOC-20. Higher intensity treatment, inpatient services, primary healthcare settings and settings identified with limited financial resources and reduced space/time for each family were other variables significantly associated with less favourable MPOC-20 ratings. Conclusions: The perception of FCC provided was fairly positive, with some areas of improvement, such as the domain of provision of information. Professionals should, therefore, provide better communication and take more time in giving information and attention to parents. Potential sources of variation in parent perceptions of FCC based on family characteri

Published
2017

24. Patient preferences for heart valve disease intervention

Author

Simon Fifer, Brittany Keen, Polo Guilbert‐Wright, Kaoru Yamabe, and Dale J. Murdoch

Subjects
discrete choice experiment, heart valve disease, patient preference, Medicine (General), R5-920, Public aspects of medicine, RA1-1270
Abstract

Abstract Background This study aimed to determine how patients trade‐off the benefits and risks of two different types of procedures used to treat heart valve disease (HVD). It also aimed to determine patients' preferences for HVD treatments (predicted uptake) and the relative importance of each treatment attribute. Methods A discrete choice experiment (DCE) was conducted in Australia and Japan with patients who required a heart valve procedure. Patients were stratified into three categories: no prior procedure experience, minimally invasive procedure experience and invasive procedure experience. DCE attributes included risk of mortality; risk of stroke; needing dialysis; needing a new pacemaker; valve durability; independence 1 month after surgery; and out‐of‐pocket expenses. Participants chose between two hypothetical labelled approaches to therapy (‘invasive procedure’ and ‘minimally invasive procedure’), with a separate opt‐out included. A mixed multinomial logit model was used to analyse preferences. Results The DCE was completed by 143 Australian and 206 Japanese patients. Both populations demonstrated an overall preference for the minimally invasive procedure over the invasive procedure. All attributes tested significantly predicted choice and were important to patient decision‐making. However, patients' choices were most influenced by the durability of the valve and the likelihood of independence postprocedure, irrespective of their prior procedure experience. Differences in preference were observed between Australian and Japanese patients; valve durability was the most important attribute among Australian patients, while Japanese patients emphasised regaining independence postsurgery. Risk of mortality was less important relative to other key attributes in Japan; however, it remained significant to the model. Conclusions HVD patients prefer a minimally invasive procedure over an invasive procedure, irrespective of prior treatment experience. Key attributes contributing to treatment preferences are valve durability and faster recovery. These results can be used to help inform healthcare decision‐makers about what features of heart valve procedures patients value most. Patient and Public Contribution People with lived experience of HVD were included in multiple stages of the design phase of this research. First, patients and doctors were consulted by taking part in qualitative interviews. The qualitative interviews helped inform which treatment attributes to include in the DCE based on what was important to those with lived experience and those who help make treatment decisions on behalf of patients. Qualitative interview participants also assisted with the framing of questions in the online survey to ensure the terminology was patient‐friendly and relevant to those with lived experience. Following qualitative interviews, the DCE attribute list was agreed on in expert consultation with a steering committee, which included patient representatives and treating physicians (interventional cardiologists, cardiothoracic surgeons). The survey was also pilot tested with a small sample of patients and minor adjustments were made to the wording to ensure it was appropriate and meaningful to those with lived experience of HVD.

Published
2024
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25. Family-centred care for children and young people with cerebral palsy: results from an Italian multicenter observational study

Author

Molinaro, A., Fedrizzi, Ermellina, Calza, S., Pagliano, E., Galli, J., Fazzi, E., Trabacca, A., Vespino, T., Gallino, F., Villani, A., Picciolini, Odoardo, Cozzaglio, M., Baranello, G., Zambonin, F., Daniela, F., Mandalari, P., Mirabile, L., Nacinovich, R., Broggi, F., De Polo, G., Da Ruos, F., Cazzagon, M., Godio, M., Piantoni, Chiara, Dusi, E., Marzaroli, M., Fusari, Donatella, Arisi, D., Magri, Stefania, Landi, N., Roberti, L., Signorini, S., Luparia, A., Sabbadini, M., Riccioli, N., Turconi, ANNA CARLA, Molteni, Francesca, Marcelli, M., Di Brina, C., Molinaro, A, Fedrizzi, E, Calza, S, Pagliano, E, Galli, J, Fazzi, E, Trabacca, A, Vespino, T, Gallino, F, Villani, A, Picciolini, O, Cozzaglio, M, Baranello, G, Zambonin, F, Daniela, F, Mandalari, P, Mirabile, L, Nacinovich, R, Broggi, F, De Polo, G, Da Ruos, F, Cazzagon, M, Godio, M, Piantoni, C, Dusi, E, Marzaroli, M, Fusari, D, Arisi, D, Magri, S, Landi, N, Roberti, L, Signorini, S, Luparia, A, Sabbadini, M, Riccioli, N, Turconi, A, Molteni, F, Marcelli, M, and Di Brina, C

Subjects
Male, cerebral palsy, family-centred care, family-centred service, MPOC-20, MPOC-SP, service delivery, Adolescent, Caregivers, Cerebral Palsy, Child, Child, Preschool, Delivery of Health Care, Integrated, Family, Female, Health Personnel, Hospitalization, Humans, Infant, Infant, Newborn, Interpersonal Relations, Italy, Primary Health Care, Young Adult, Adolescent Health Services, Child Health Services, Integrated, Preschool, Newborn, MED/39 - NEUROPSICHIATRIA INFANTILE, Delivery of Health Care
Abstract

Background: Family-centred care (FCC) is recognized as the model of best practice for the provision of services for children who have physical disabilities and their families. Objective: To assess the overall perception of FCC provided in an Italian network of 17 rehabilitation services, as perceived by parents of children with cerebral palsy and professionals, and to explore whether children, families, service providers and service-related characteristics influence parent satisfaction regarding service provision in an FCC practice. Methods: The Measure of Processes of Care (MPOC-20) for parents/caregivers and the Measure of Processes of Care for Service Providers (MPOC-SP) for healthcare providers were used. For the purposes of the study, an ad hoc information form was developed to collect information concerning children, families, service providers and services. Results: A total of 382 parents/caregivers and 269 healthcare providers completed the MPOC questionnaires. Parents and service providers both identified the domains for enabling partnerships and interpersonal sensitivity as a strength, while the domain relating to general information was always scored the lowest. An advanced maternal age, being a single parent, being unemployed and having lower socio-economic status were factors identified as individually predictive of lower FCC scores on the MPOC-20. Higher intensity treatment, inpatient services, primary healthcare settings and settings identified with limited financial resources and reduced space/time for each family were other variables significantly associated with less favourable MPOC-20 ratings. Conclusions: The perception of FCC provided was fairly positive, with some areas of improvement, such as the domain of provision of information. Professionals should, therefore, provide better communication and take more time in giving information and attention to parents. Potential sources of variation in parent perceptions of FCC based on family characteristics and the organization of services highlight the importance the need to support services through the provision of greater financial and human resources.

Published
2017

27. N-Acetylglutamate Synthase Deficiency Due to a Recurrent Sequence Variant in the N-acetylglutamate Synthase Enhancer Region

Author

Williams, M. (Monique), Burlina, A.B. (Alberto), Rubert, L. (Laura), Polo, G. (Giulia), Ruijter, G.J.G. (George), Born, M. (Myrthe) van den, Rüfenacht, V. (Véronique), Haskins, N. (Nantaporn), Zutven, L.J.C.M. (Laura) van, Tuchman, M. (Mendel), Saris, J.J. (Jasper J.), Häberle, J. (Johannes), Caldovic, L. (Ljubica), Williams, M. (Monique), Burlina, A.B. (Alberto), Rubert, L. (Laura), Polo, G. (Giulia), Ruijter, G.J.G. (George), Born, M. (Myrthe) van den, Rüfenacht, V. (Véronique), Haskins, N. (Nantaporn), Zutven, L.J.C.M. (Laura) van, Tuchman, M. (Mendel), Saris, J.J. (Jasper J.), Häberle, J. (Johannes), and Caldovic, L. (Ljubica)

Abstract

N-acetylglutamate synthase deficiency (NAGSD, MIM #237310) is an autosomal recessive disorder of the urea cycle that results from absent or decreased production of N-acetylglutamate (NAG) due to either decreased NAGS gene expression or defective NAGS enzyme. NAG is essential for the activity of carbamylphosphate synthetase 1 (CPS1), the first and rate-limiting enzyme of the urea cycle. NAGSD is the only urea cycle disorder that can be treated with a single drug, N-carbamylglutamate (NCG), which can activate CPS1 and completely restore ureagenesis in patients with NAGSD. We describe a novel sequence variant NM_153006.2:c.-3026C > T in the NAGS enhancer that was found in three patients from two families with NAGSD; two patients had hyperammonemia that resolved upon treatment with NCG, while the third patient increased dietary protein intake after initiation of NCG therapy. Two patients were homozygous for the variant while the third patient had the c.-3026C > T variant and a partial uniparental disomy that encompassed the NAGS gene on chromosome 17. The c.-3026C > T sequence variant affects a base pair that is highly conserved in vertebrates; the variant is predicted to be deleterious by several bioinformatics tools. Functional assays in cultured HepG2 cells demonstrated that the c.-3026C > T substitution could result in reduced expression of the NAGS gene. These findings underscore the importance of analyzing NAGS gene regulatory regions when looking for molecular causes of NAGSD.

Published
2018
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28. N-Acetylglutamate Synthase Deficiency Due to a Recurrent Sequence Variant in the N-acetylglutamate Synthase Enhancer Region

Author

Williams, Monique, Burlina, A, Rubert, L, Polo, G, Ruijter, George, van den Born, Myrthe, Rufenacht, V, Haskins, N, van Zutven, Laura, Tuchman, M, Saris, Jasper, Haberle, J, Caldovic, L, Williams, Monique, Burlina, A, Rubert, L, Polo, G, Ruijter, George, van den Born, Myrthe, Rufenacht, V, Haskins, N, van Zutven, Laura, Tuchman, M, Saris, Jasper, Haberle, J, and Caldovic, L

Published
2018

31. Behavior Evaluation Of An Anchored Wall

Author

Edison, Polo G. Yohn and Rocha F. Pedricto

Subjects
Strain gauges, Retaining wall, Anchors, Instrumentation
Abstract

This work presents a study about a retaining structure designed for the duplication of the rail FEPASA on the 74th km between Santos and São Paulo. This structure, an anchored retaining wall, was instrumented in the anchors heads with strain gauges in order to monitor its loads. The load measurements occurred during the performance test, locking and also after the works were concluded. A decrease on anchors loads is noticed at the moment immediately after the locking, during construction and after the works finished. It was observed that a loss of load in the anchors occurred to a maximum of 54%., {"references":["Terzaghi, K. and Peck R. (1967) \"Soil Mechanics in Engineering Practice\" John Wiley & Sons, New York.","Terzaghi, K., Peck, R. and Mesri G. (1996) \"Soil Mechanics in Engineering Practice\" John Wiley & Sons, New York.","Sabatini, et al. Ground Anchors and Anchored Systems. Geotechnical Engineering Circular No. 4 (FHWA-if-99-015) Federal Highway Administration, Washington D.C .","Zeitoune, N.M. Instrumentação e Analise de uma Cortina Atirantada Localizada no km 74 da Ferrovia Santos – São Paulo, FEPASA. 1982. 263p. Dissertação (Mestrado em Engenharia Civil) – Pontifícia Universidade Católica do Rio de Janeiro - RJ.","Brahana D. C., Tanner W. M., Mullins l. D. Deflection and Earth Pressure Measurements of an Anchored Concrete Shoring Wall in:. International Symposium on Field Measurements in Geomechanics. 7th. 2007, Boston, Massachusetts.","Jaky, J. (1944) \"The Coefficient of Earth Pressure at Rest\". Journal of Society of Hungarian Architects and Engineers, Budapest, Hungary, pp. 355-358."]}

Published
2016
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33. Behavior Evaluation of an Anchored Wall

Author

Polo G. Yohn Edison and Rocha F. Pedricto

Subjects
Strain gauges, Retaining wall, Anchors, Instrumentation
Abstract

This work presents a study about a retaining structure designed for the duplication of the rail FEPASA on the 74th km between Santos and São Paulo. This structure, an anchored retaining wall, was instrumented in the anchors heads with strain gauges in order to monitor its loads. The load measurements occurred during the performance test, locking and also after the works were concluded. A decrease on anchors loads is noticed at the moment immediately after the locking, during construction and after the works finished. It was observed that a loss of load in the anchors occurred to a maximum of 54%.

Published
2016
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35. Muro cortante de placa de acero – aplicación a la construcción en Panamá

Author

Polo G., Gabriel E.

Subjects
cortante
Abstract

El sistema de muro cortante de placa de acero (SPSW – Steel Plate Shear Wall), como su nombre lo indica, es un sistema compuesto por un panel de acero (alma), confinado por vigas y columnas (elementos de borde), típicamente de acero estructural. Entre cada uno de los niveles de piso de la edificación se coloca un panel de acero, permitiendo la continuidad de las placas.

Published
2013

37. Two administrations of an intravaginal progesterone device on the induction of ovarian cyclicity in anestrous mares

Author

Polo, G, primary, Weiss, R R, additional, Formighieri Bertol, M E, additional, Capalbo Milleo Polasek, T, additional, De Lima, L G V, additional, Kozicki, L E, additional, Dell’aqua Jr, J A, additional, Camargo, C E, additional, Saporski Segui, M, additional, Macan, R, additional, Alberini, V, additional, and Ladewig, E, additional

Published
2016
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44. Testing and Analysis of Two Deep Beams Designed Using Strut-and-Tie Method.

Author

Martinez, G. A., Beiter, K. S., Ghiami Azad, A. R., Polo, G. E., Shinn, R. L., Hrynyk, T. D., and Bayrak, O.

Subjects
CONCRETE beams, STRUT & tie models, BRIDGE design & construction, FAILURE mode & effects analysis, REINFORCED concrete, FINITE element method
Abstract

The seventh edition of the AASHTO LRFD Bridge Design Specifications (2016 interim) includes revised provisions for the design of deep beams using the strut-and-tie method. The validity and accuracy of these provisions as applied to simply supported deep beams loaded in a manner that generates an inflection point between the supports was investigated in this research. As part of a course-related laboratory investigation, graduate students at the University of Texas at Austin used these provisions to design two reduced-scale deep beams. The specimens were subsequently constructed and tested. The experimental behaviors of the specimens including governing failure modes, load-displacement curves, and their ultimate capacities were investigated and compared with estimates developed from the strutand-tie method. The results obtained validated the suitability of the revised provisions for the design of deep beams with inflection points located between supports. Additionally, the students developed pre-test estimates for the behaviors and strengths of the two deep beam specimens using the finite element software program VecTor2. While there was some variation among the computed responses, the blind predictions accurately captured governing failure modes and provided reasonable capacity estimates. [ABSTRACT FROM AUTHOR]

Published
2017
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47. Studio Triveneto Lamotrigina: Risultati migliori per la casistica di sesso femminile nelle epilessie

Author

Garofalo, P. G, Ghiotto, M. C., Bassetti, M. A., Piovan, T., Tonon, A., Pauletto, Giada, Durisotti, C., Panozzo, M. T., Amerio, R., Artuso, G., Benetello, P. P., Bergonzi, Paolo, Biamino, P., Bongiovanni, L. G., Boniver, C., Bouquet, F., Cagnin, G., Calzolari, S., Candeago, R. M., Cernetti, R., Costa, Pietro, Crichiutti, Giovanni, Cristofori, Guido, Cruciatti, B., Dal Pozzo, F., DE MARCO, Pasquale, De Polo, G., Dolso, P. G., Gigli, Gian Luigi, Idone, D., Lucci, Bruno, Marinig, Roberto, Masè, G., Miottello, P. G., Munerati, V., Orrico, D., Paladin, F., Panico, ANNA CLARA, Pianalto, P., Privato, Fiorenza, Prugger, M., Rozza, L., Sanson, F., Schoenhuber, R., Serena, Marina, Stenta, G., Toldo, Massimiliano, Tortorici, G., Vecchi, M., and Zamagni, M.

Subjects
Survival Curve, Gender, Women, Neurology (clinical), Lamotrigine
Published
2003

49. Studio triveneto sulla Lamotrigina: Mantenimento ed efficacia terapeutica nell'arco di due anni

Author

Garofalo, P. G, DE MARCO, Pasquale, Benetello, P. P., Boniver, C., Marotti, E., Amerio, R., Bassetti, M. A., Bergonzi, Paolo, Biamino, P., Bongiovanni, L. G., Bouquet, F., Cagnin, G., Calzolari, S., Cernetti, R., Costa, Pietro, Cristofori, Guido, Cruciatti, B., Dal Pozzo, F., De Polo, G., Dolso, P. G., Gigli, Gian Luigi, Idone, D., Lucci, Bruno, Marinig, Roberto, Masè, G., Miottello, P. G., Munerati, V., Orrico, D., Paladin, F., Panico, ANNA CLARA, Pauletto, Giada, Pianalto, P., Privato, Fiorenza, Prugger, M., Rozza, L., Sanson, F., Schoenhuber, R., Serena, Marina, Toldo, Massimiliano, Tonon, A., Tortorici, G., and Zamagni, M.

Subjects
Persistence of Efficacy, Lamotrigine, Neurology (clinical)
Published
2002

50. Studio triveneto sulla lamotrigina: Correlazione tra efficacia del farmaco e l'età di esordio dell'epilessia nelle varie forme sindromiche

Author

Garofalo, P. G, DE MARCO, Pasquale, Boniver, C., Benetello, P. P., Marotti, E., Amerio, R., Bassetti, M. A., Bergonzi, Paolo, Biamino, P., Bongiovanni, L. G., Bouquet, F., Cagnin, G., Calzolari, S., Cernetti, R., Costa, Pietro, Cristofori, Guido, Cruciatti, B., Dal Pozzo, F., De Polo, G., Dolso, P. G., Gigli, Gian Luigi, Idone, D., Lucci, Bruno, Marinig, Roberto, Masè, G., Miottello, P. G., Munerati, V., Orrico, D., Paladin, F., Panico, ANNA CLARA, Pauletto, Giada, Pianalto, P., Privato, Fiorenza, Prugger, M., Rozza, L., Sanson, F., Schoenhuber, R., Serena, Marina, Toldo, Massimiliano, Tonon, A., Tortorici, G., and Zamagni, M.

Subjects
Epilepsy Onset Age, Lamotrigine, Neurology (clinical)
Published
2002

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