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With the increasing complexity of buildings and their facilities, integrating IoT infrastructure with digital building models has become essential. This integration allows facility managers to make informed decisions using spatially oriented sensor data, creating a digital twin of the building for more efficient resource management and problem-solving. This contribution reviews various case studies that demonstrate the potential of IoT-driven BIM models, showcasing approaches to optimize thermal comfort, HVAC performance, and building monitoring using GIS data and CFD simulations. To streamline these systems, the article introduces a proprietary classification system for IoT sensors and actors. Lastly, the paper presents a unique approach to integrating this classification system with BIM while managing spatial data, further enhancing the efficiency of facility management.

Whitewater slalom, a thrilling and challenging water sport, requires carefully designed courses that provide a dynamic and engaging experience for athletes. Traditional methods of designing slalom courses in natural riverbeds have relied on manual measurements and estimations, which can be time-consuming, labour-intensive, and subject to human error. However, with the advent of photogrammetry, a cutting-edge technology that involves the use of aerial or ground-based cameras to capture and process 3D data from images, there is a new frontier in designing and analysing white water slalom courses.This article explores the usage of photogrammetry in the context of white-water slalom course design in natural riverbeds. It highlights how photogrammetry can revolutionize the course design process by providing accurate and detailed 3D models of the riverbed terrain, which can be used for virtual simulations, rapid prototyping, and precise analysis of different design options. The advantages of using photogrammetry include improved accuracy, efficiency, and cost-effectiveness in comparison to traditional methods.The article concludes by discussing the challenges and limitations of using photogrammetry for whitewater slalom course design, including issues related to data acquisition, processing, and accuracy. Despite these challenges, the potential of photogrammetry in revolutionizing the design and analysis of white-water slalom courses in natural riverbeds is immense, and it opens up exciting opportunities for further research, innovation, and advancement in the field of water sports.

The article provides an analysis of hydraulic technical requirements based on model investigations of the artificial slalom courses designed for the Tokyo 2020 Olympic Games. A main, “Competition Course“ will be used for top level sporting events such as the Olympic Games, World Championships and/or World Cups, as well as commercial rafting and other recreational activities in Legacy. A second “Training Course“ will be used for pre-race warmup, as well as for post-Games recreation and training opportunities for all varieties of whitewater enthusiasts, including youth development and instructional programs. The main aim of the physical model investigations was to evaluate these courses designs from a hydraulic point of view - to validate technical performance objectives and to determine the optimal positioning for hydraulic features within the channels, with respect to design criteria which are: optimal water depth at prescribed flows, optimal current velocities, optimal Games-ready hydraulic configurations, safety criteria compliance, suitability for various Legacy uses (per IOC intent).

The modelling of a secondary settling tank area using numerical methods has been quite extensively explored and researched by numerous authors and papers. These developed models utilize different approaches, from efforts to create a solely deterministic models to attempts to generalize calibrated empirical models. Nevertheless, the processes are not easy to simulate due to the high complexity of the physics involving multiple phases, bio-chemical reactions and non-Newtonian fluids. Therefore, an additional research effort should be focused on improving these models and to validate and verify them against experimental measurements. This article is focused on creating a numerical model for settling tank optimization, which builds on the previous works and is then extended with newly obtained relations from vast experimental measuring using the database approach. The objective is to create a model, which is based on an obtained relation and could easily be adjusted to different flow scenarios and sludge types at different wastewater treatment plants.

The paper deals with the design of swinging self-clean screen bars and the assessment of pressure losses in the combined sewer overflow chamber (HOBAS CSO Chamber), sold by the company HOBAS. The HOBAS CSO Chamber ensures a safe transfer of rainwater during a major rain event. The main goal of the research was to determine the pressure losses of the overflow chamber under various conditions - without self-clean screen bars; with screen bars without impurities and with screen bars partially or fully clogged with various impurities. The measurements were performed on a 1 : 5 scale physical model of CSO using 4 probes for measuring level heights. From the measured values, the coefficients of local losses were calculated, which were then entered into the currently used design table of flow capacities of the CSO HOBAC Chamber. At the same time, the optimal shape of individual rods of swinging self-clean bars was investigated, so that the oscillation of the free ends of the rods supports the separation and self-cleaning function during their operation. The research was conducted on a 1 : 1 scale model, so that impurities present in the CSO during the overflow (i.e. textile, cosmetic handkerchiefs, feminine hygiene products, condoms and others) could be used directly in the measurement. At the end of the experiments, the variants of the rods of screen bars that were the most effective in the separation and self-cleaning function were selected. The self-cleaning effect, which occurs at the end of the rain event and ensures that the CSO is free of impurities and ready for further use, was subsequently tested with the selected variant of the rods.

Lukas Pollert,1 Zuzana Prikrylova,1 Jan Berousek,1 Frantisek Mosna,1 Robert Lischke2 1Department of Anaesthesiology and Intensive Care, 2nd Faculty of Medicine, 23rd Surgical Department, 1st Faculty of Medicine, Charles University in Prague and Motol University Hospital, Praha, Czech Republic Background: Lung transplantation is considered an established treatment for patients with end-stage chronic respiratory failure. Patients with acute respiratory failure requiring respiratory support with invasive mechanical ventilation while awaiting lung transplantation are at high risk of death. Extracorporeal membrane oxygenation (ECMO) has been proposed as an alternative bridging strategy to mechanical ventilation. The shear stress created by the mechanical pumps causes changes in the hematological system in almost all patients treated with ECMO. An antithrombotic strategy to mitigate ECMO bleeding and thrombotic complications is necessary. The use of thrombolytic therapy is recommended for patients with acute symptomatic embolism with associated hypotension or shock. In this setting, the hemodynamic benefits of thrombolytic treatment far outweigh its bleeding risk.Case presentation: This case report describes a 32-year-old woman suffering from lymphangioleiomyomatosis, who underwent urgent double-lung transplantation. This patient was maintained on ECMO preoperatively, perioperatively, and postoperatively due to life-threatening hypoxemia caused by the progression of her pulmonary tissue damage. Multiple thrombi developed in the early postoperative period, in both right and left heart atria. Direct thrombolysis was successfully performed on the first postoperative day.Conclusion: According to the current published literature, direct thrombolysis of thrombi in both right and left atria in a patient supported on ECMO following urgent double-lung transplantation is an extremely rare treatment method. Even when taking into account all of the risks associated with thrombolysis and arteriovenous ECMO support, we found that this technique is very effective and, without a doubt, it saved the life of our patient. Keywords: thrombolysis, double-lung transplantation, extracorporeal membrane oxygenation, general anesthesia, lymphangioleiomyomatosis

The aim of the research was to carry out a hydraulic design of rowing/sculling and paddling simulator. Nowadays there are two main approaches in the simulator design. The first one includes a static water with no artificial movement and counts on specially cut oars to provide the same resistance in the water. The second approach, on the other hand uses pumps or similar devices to force the water to circulate but both of the designs share many problems. Such problems are affecting already built facilities and can be summarized as unrealistic feeling, unwanted turbulent flow and bad velocity profile. Therefore, the goal was to design a new rowing simulator that would provide nature-like conditions for the racers and provide an unmatched experience. In order to accomplish this challenge, it was decided to use in-depth numerical modeling to solve the hydraulic problems. The general measures for the design were taken in accordance with space availability of the simulator ́s housing. The entire research was coordinated with other stages of the construction using BIM. The detailed geometry was designed using a numerical model in Ansys Fluent and parametric auto-optimization tools which led to minimum negative hydraulic phenomena and decreased investment and operational costs due to the decreased hydraulic losses in the system.

During the last 30 years, a number of devices has been developed for dynamic separation of settle able solids in wastewaters. Initially, these separators were used for control of Combined Sewer Overflow (CSO) pollution by retaining the bulk of solids in the underflow, directed to the sewage treatment plant (STP), and allowing combined sewage with reduced pollutant loads to overflow from the sewer systém. This paper is describing CSO “OK 3D Evropská” in Prague 6 on Evropská Street. Inlet to CSO is 3 m diameter tube collecting water from location of Oepy, Vokovice, Liboc and Ruzyně. The outflow throttle pipe is 1.1 m in diameter and continues to central wastewater treatment plant and overflow is ending in Šárecký creek. Šárecký creek flows through the Šárka valley which is environmentally protected area. CSO “OK 3D Evropská" has high overflow crest and probability of the function is 0.44 per year.

Abstract: Background: This study provides new information on how rapidly and extensively alcohol is absorbed after Roux-en-Y gastric bypass (RYGB). Previous alcohol pharmacokinetic research in RYGB patients has not reported blood alcohol concentrations in this early time period after ingestion. The objective of this study was to examine the rate and extent of alcohol absorption, particularly in the first 10 minutes after a dose of alcohol. Methods: Five female participants who had undergone RYGB 3 to 4 years previously completed the study. Participants were given .3 g/kg of actual weight of ethanol. After the dose of alcohol, blood samples were collected through an indwelling intravenous catheter every minute for the first 5 minutes and at 7.5, 10, 20, and 60 minutes. Results: The observed mean Cmax was 138.4±28.6 mg/dL (range 98.0–170.0 mg/dL), and the observed mean Tmax was 5.4±3.1 minutes (range 2–10 minutes) after alcohol consumption. Conclusions: Within minutes after consumption of a beverage containing a modest amount of alcohol, post-RYGB patients achieve disproportionately high blood alcohol concentrations. All 5 participants in this study reached blood alcohol concentrations>.08%, the legal driving limit in the United States, within 10 minutes after a dose of alcohol. Clinicians are encouraged to educate patients about the marked changes in alcohol pharmacokinetics that are they are likely to experience after RYGB and to guide patients in making modifications to alcohol intake after surgery accordingly. [Copyright &y& Elsevier]

Abstract: Today the use of nanoparticles based on magnetite Fe3O4 or maghemite γ-Fe2O3 for magnetic fluid hyperthermia (MFH) application is preferred for evident reasons as biocompatibility and easy synthesis. However, they only show moderate heating capacities because their magnetic properties cannot be simply adjusted to a suitable level. A possible improvement of the MFH technique consists in using more complex magnetic oxides such as: (i) cobalt ferrite and derived phases whose magnetic properties depend on the composition and coercivity is essentially controlled by the magnetocrystalline and/or shape anisotropy, (ii) La1−x SrxMnO3 perovskites whose magnetic properties are influenced by the composition and crystallite size, and (iii) SrFe12O19/γ-Fe2O3 composites whose magnetic properties are mainly controlled by the ratio of the respective magnetic phases. Our main results concerning the synthesis of these compounds in the form of submicronic particles, their magnetic properties and their heating abilities are summarized, compared and discussed in this paper. [Copyright &y& Elsevier]

Abstract: Magnetic nanoparticles have attracted attention because of their current and potential usefulness as contrast agents for magnetic resonance imaging (MRI) or colloidal mediators for cancer magnetic hyperthermia. This contribution examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint (e.g. relaxivity for MRI and specific absorption rate for hyperthermia), the factors affecting their biodistribution and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells. Then, the synthesis strategies developed in our group are presented and focused on covalent platforms capable to be tailor-derivatised by surface molecular chemistry. The opportunity of using more complex oxides than conventional magnetite for controlling the in vivo temperature is also discussed. [Copyright &y& Elsevier]