424 results on '"Polito C"'
Search Results
2. Long-term use of pharmacological treatment in Alzheimer’s disease: a retrospective cohort study in real-world clinical practice
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Lombardi, G, Lombardi, N, Bettiol, A, Crescioli, G, Ferrari, C, Lucidi, G, Polito, C, Berti, V, Bessi, V, Bagnoli, S, Nacmias, B, Vannacci, A, and Sorbi, S
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- 2022
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3. Patients on Benralizumab, Dupilumab, or Mepolizumab Have Lower Post-vaccination SARS-CoV-2 Immunity
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Lamothe, P., primary, Runnstrom, M., additional, Faliti, C., additional, Cheedarla, N., additional, Moreno, A., additional, Suthar, M., additional, Nahata, R., additional, Ravindran, M., additional, Haddad, N., additional, Morrison-Porter, A., additional, Quehl, H., additional, Ramonell, R.P., additional, Woodruff, M., additional, Anam, F., additional, Zhang, R., additional, Swenson, C., additional, Polito, C., additional, Neveu, W.A., additional, Patel, R., additional, Smirnova, N., additional, Kim, C., additional, Hentenaar, I., additional, Kyu, S., additional, Usman, S., additional, Ngo, T., additional, Guo, Z., additional, Wu, H., additional, Daiss, J., additional, Park, J., additional, Wali, B., additional, Manning, K., additional, Ellis, M., additional, Sharma, S., additional, Holguin, F.L., additional, Cheedarla, S., additional, Neish, A., additional, Roback, J., additional, Sanz, I., additional, and Lee, F.E.-H., additional
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- 2024
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4. Optimized protocol for repeated chest X-ray in a pediatric cardiac intensive care unit
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Polito, C., Genovese, E., Longo, M., Cassano, B., Donatiello, S., Secinaro, A., Magistrelli, A., Tomà, P., and Cannatà, V.
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- 2021
- Full Text
- View/download PDF
5. GFR DETERMINATION FROM PLASMA CLEARANCE CURVE: A SIMPLIFIED PROCEDURE USING BLOOD SAMPLES AND HAEMATOCRIT
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Ciucci, D., primary, Camillocci, E. Solfaroli, additional, Palmieri, D., additional, Donatiello, S., additional, Napolitano, A., additional, Polito, C., additional, Villani, M.F., additional, Pizzoferro, M., additional, Altini, C., additional, Garganese, M.C., additional, and Cannatà, V., additional
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- 2023
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6. REVIEW OF METHODS AND SOFTWARE FOR PATIENTS AND FETAL DOSE ASSESSMENT
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Cannatà, V., primary, Ciucci, D., additional, Donatiello, S., additional, Napolitano, A., additional, and Polito, C., additional
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- 2023
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- View/download PDF
7. LaBr[formula omitted]:Ce and NaI:Tl performance comparison for single photon emission detector
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Bettiol, M., Preziosi, E., Borrazzo, C., Polito, C., Cinti, M.N., Pellegrini, R., and Pani, R.
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- 2018
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8. Imaging performances of a small FoV gamma camera based on CRY018 scintillation crystal
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Polito, C., Pani, R., Frantellizzi, V., De Vincentis, G., and Pellegrini, R.
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- 2018
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9. Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
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Bussy, A., Levy, J., Best, T., Patel, R., Cupo, L., Van Langenhove, T., Nielsen, J., Pijnenburg, Y., Waldö, M., Remes, A., Schroeter, M., Santana, I., Pasquier, F., Otto, M., Danek, A., Levin, J., Le Ber, I., Vandenberghe, R., Synofzik, M., Moreno, F., de Mendonça, A., Sanchez‐Valle, R., Laforce, R., Langheinrich, T., Gerhard, A., Graff, C., Butler, C., Sorbi, S., Jiskoot, L., Seelaar, H., van Swieten, J., Finger, E., Tartaglia, M., Masellis, M., Tiraboschi, P., Galimberti, D., Borroni, B., Rowe, J., Bocchetta, M., Rohrer, J., Devenyi, G., Chakravarty, M., Ducharme, S., Esteve, A., Nelson, A., Bouzigues, A., Heller, C., Greaves, C., Cash, D., Thomas, D., Todd, E., Benotmane, H., Zetterberg, H., Swift, I., Nicholas, J., Samra, K., Russell, L., Shafei, R., Convery, R., Timberlake, C., Cope, T., Rittman, T., Benussi, A., Premi, E., Gasparotti, R., Archetti, S., Gazzina, S., Cantoni, V., Arighi, A., Fenoglio, C., Scarpini, E., Fumagalli, G., Borracci, V., Rossi, G., Giaccone, G., Di Fede, G., Caroppo, P., Prioni, S., Redaelli, V., Tang‐Wai, D., Rogaeva, E., Castelo‐Branco, M., Freedman, M., Keren, R., Black, S., Mitchell, S., Shoesmith, C., Bartha, R., Rademakers, R., Poos, J., Papma, J., Giannini, L., van Minkelen, R., Nacmias, B., Ferrari, C., Polito, C., Lombardi, G., Bessi, V., Veldsman, M., Andersson, C., Thonberg, H., Öijerstedt, L., Jelic, V., Thompson, P., Lladó, A., Antonell, A., Olives, J., Balasa, M., Bargalló, N., Borrego‐Ecija, S., Verdelho, A., Maruta, C., Ferreira, C., Miltenberger, G., do Couto, F., Gabilondo, A., Gorostidi, A., Villanua, J., Cañada, M., Tainta, M., Zulaica, M., Barandiaran, M., Alves, P., Bender, B., Wilke, C., Graf, L., Vogels, A., Vandenbulcke, M., Van Damme, P., Bruffaerts, R., Poesen, K., Rosa‐Neto, P., Gauthier, S., Camuzat, A., Brice, A., Bertrand, A., Funkiewiez, A., Rinaldi, D., Saracino, D., Colliot, O., Sayah, S., Prix, C., Wlasich, E., Wagemann, O., Loosli, S., Schönecker, S., Hoegen, T., Lombardi, J., Anderl‐Straub, S., Rollin, A., Kuchcinski, G., Bertoux, M., Lebouvier, T., Deramecourt, V., Santiago, B., Duro, D., Leitão, M., Almeida, M., Tábuas‐Pereira, M., Afonso, S., Engel, A., Polyakova, M., Erasmus MC other, Neurology, Radiology & Nuclear Medicine, Clinical Genetics, GENetic Frontotemporal dementia Initiative (GENFI), Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, Verdelho, Ana, Maruta, Carolina, Ferreira, Catarina B, Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Engel, Annerose, Polyakova, Maryna, Esteve, Aitana Sogorb, Nelson, Annabel, Bouzigues, Arabella, Heller, Carolin, Greaves, Caroline V, Cash, David, Thomas, David L, Todd, Emily, Benotmane, Hanya, Zetterberg, Henrik, Swift, Imogen J, Nicholas, Jennifer, Samra, Kiran, Russell, Lucy L, Bocchetta, Martina, Shafei, Rachelle, Convery, Rhian S, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Scarpini, Elio, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Tiraboschi, Pietro, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M, Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Bussy, Aurélie [0000-0001-6695-9941], Nielsen, Jørgen E [0000-0003-0453-5582], Borroni, Barbara [0000-0001-9340-9814], Bocchetta, Martina [0000-0003-1814-5024], Devenyi, Gabriel A [0000-0002-7766-1187], Apollo - University of Cambridge Repository, and Amsterdam Neuroscience - Neurodegeneration
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C9orf72 Protein ,Radiological and Ultrasound Technology ,Medizin ,frontotemporal dementia ,Neurology ,Frontotemporal Dementia ,Cerebellum ,Humans ,magnetic resonance imaging ,genetics ,neuropsychiatry ,Radiology, Nuclear Medicine and imaging ,Human medicine ,ddc:610 ,Neurology (clinical) ,Atrophy ,Anatomy ,genetics [Frontotemporal Dementia] ,genetics [C9orf72 Protein] - Abstract
Funder: Alzheimer Society of Canada; Id: http://dx.doi.org/10.13039/501100000143, Funder: Weston Brain Institute; Id: http://dx.doi.org/10.13039/100012479, Funder: Fonds de Recherche du Québec ‐ Santé, Funder: Canadian Institutes of Health Research; Id: http://dx.doi.org/10.13039/501100000024, Funder: NIHR Rare Diseases Translational Research Collaboration, Funder: Deutsche Forschungsgemeinschaft; Id: http://dx.doi.org/10.13039/501100001659, Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD symptomatology. The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Our study included 983 participants from the Genetic Frontotemporal dementia Initiative including mutation carriers and noncarrier first-degree relatives of known symptomatic carriers. Voxel-wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses (PLS) were used to link morphometry and behavior. In presymptomatic C9orf72 expansion carriers, thalamic atrophy was found compared to noncarriers, suggesting the importance of this structure in FTD prodromes. PLS analyses demonstrated that the cerebello-subcortical circuitry is related to neuropsychiatric symptoms, with significant overlap in brain/behavior patterns, but also specificity for each genetic mutation group. The largest differences were in the cerebellar atrophy (larger extent in C9orf72 expansion group) and more prominent amygdalar volume reduction in the MAPT group. Brain scores in the C9orf72 expansion carriers and MAPT carriers demonstrated covariation patterns concordant with atrophy patterns detectable up to 20 years before expected symptom onset. Overall, these results demonstrated the important role of the subcortical structures in genetic FTD symptom expression, particularly the cerebellum in C9orf72 and the amygdala in MAPT carriers.
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- 2023
10. On Finite Matrix Bi-Dimensional Formulation of $D=4n+2$ Classical Field Models
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Colatto, L. P., Penna, A. L. A., and Polito, C. M. M.
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High Energy Physics - Theory - Abstract
We introduce a basis for a bi-dimensional finite matrix calculus and a bi-dimensional finite matrix action principle. As an application, we analyze scalar and spinorial fields in $D=4n+2$ in this approach. We verify that to establish a bi-dimensional matrix action principle we have to define a Dirac-algebra-modified Lebniz rule. From the bi-dimensional equations of motion, we obtain a matrix holomorphic feature for massless matrix scalar and spinorial fields., Comment: 9 pages, LaTex, revised version
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- 2000
11. Motor symptoms in genetic frontotemporal dementia: developing a new module for clinical rating scales
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Samra, K, MacDougall, AM, Peakman, G, Bouzigues, A, Bocchetta, M, Cash, DM, Greaves, CV, Convery, RS, van Swieten, JC, Jiskoot, L, Seelaar, H, Butler, CR, Fenoglio, C, Rohrer, JD, Gerhard, A, Ducharme, S, Le Ber, I, Tiraboschi, P, Santana, I, Pasquier, F, Levin, J, Shoesmith, C, Otto, M, Russell, LL, Nelson, A, Cash, D, Thomas, DL, Todd, E, Ferrari, C, Benotmane, H, Timberlake, C, Gabilondo, A, Cope, T, Rittman, T, Benussi, A, Premi, E, Gasparotti, R, Thompson, P, Archetti, S, Fumagalli, G, do Couto, FS, Borracci, V, Polito, C, Rossi, G, Giaccone, G, Di Fede, G, Caroppo, P, Ferreira, CB, Prioni, S, Langheinrich, T, Redaelli, V, Lladó, A, Bartha, R, Tang-Wai, D, Rogaeva, E, Castelo-Branco, M, Freedman, M, Keren, R, Black, S, Mitchell, S, Miltenberger, G, Rademakers, R, Poos, J, Papma, JM, Giannini, L, van Minkelen, R, Pijnenburg, Y, Gauthier, S, Nacmias, B, Lombardi, G, Bessi, V, Veldsman, M, Andersson, C, Thonberg, H, Öijerstedt, L, Prix, C, Jelic, V, Antonell, A, Graff, C, Olives, J, Balasa, M, Bargalló, N, Borrego-Ecija, S, Verdelho, A, Kuchcinski, G, Maruta, C, Gorostidi, A, Laforce, R, Villanua, J, Wlasich, E, Cañada, M, Tainta, M, Zulaica, M, Barandiaran, M, Moreno, F, Alves, P, Bender, B, Bertoux, M, Wilke, C, Lebouvier, T, Camuzat, A, Graf, L, Vogels, A, Vandenbulcke, M, Van Damme, P, Bruffaerts, R, Poesen, K, Rosa-Neto, P, Sanchez-Valle, R, Brice, A, Bertrand, A, Funkiewiez, A, Rinaldi, D, Saracino, D, Colliot, O, Sorbi, S, Sayah, S, Wagemann, O, Loosli, S, Schönecker, S, Hoegen, T, Lombardi, J, Anderl-Straub, S, Nicholas, J, Rollin, A, Deramecourt, V, Arighi, A, Santiago, B, Duro, D, Leitão, MJ, Almeida, MR, Tábuas-Pereira, M, Gazzina, S, Afonso, S, Masellis, M, Tartaglia, C, Shafei, R, Rowe, JB, Borroni, B, Finger, E, Synofzik, M, Galimberti, D, Vandenberghe, R, de Mendonça, A, Cantoni, V, Genetic FTD Initiative (GENFI), Samra, Kiran [0000-0002-3105-7099], Apollo - University of Cambridge Repository, Maruta, Carolina, Ferreira, Catarina B, Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Nelson, Annabel, Bocchetta, Martina, Cash, David, Thomas, David L, Todd, Emily, Benotmane, Hanya, Nicholas, Jennifer, Samra, Kiran, Shafei, Rachelle, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Tiraboschi, Pietro, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M, Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, and Verdelho, Ana
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Progranulin ,Clinical Neurology ,C9ORF72 ,tau Proteins ,AMYOTROPHIC-LATERAL-SCLEROSIS ,diagnosis [Frontotemporal Dementia] ,C9orf72 ,Tremor ,Genetics ,Humans ,ddc:610 ,genetics [Frontotemporal Dementia] ,genetics [C9orf72 Protein] ,MUTATION ,Science & Technology ,C9orf72 Protein ,HERITABILITY ,Amyotrophic Lateral Sclerosis ,PROGRESSIVE SUPRANUCLEAR PALSY ,COGNITIVE IMPAIRMENT ,REPEAT EXPANSION ,genetics [tau Proteins] ,Motor ,PATHOLOGICAL FEATURES ,Neurology ,FOS: Biological sciences ,Frontotemporal Dementia ,Mutation ,Human medicine ,Neurosciences & Neurology ,Neurology (clinical) ,Tau ,TAU ,Life Sciences & Biomedicine ,Frontotemporal dementia ,PARKINSONISM - Abstract
Funder: CIBERNED, Funder: Canadian Institutes of Health Research; doi: http://dx.doi.org/10.13039/501100000024, Funder: Lemaire Family Foundation, Funder: Swedish Frontotemporal Dementia Initiative, Funder: Italian Ministry of Health, Funder: Weston Brain Institute; doi: http://dx.doi.org/10.13039/100012479, Funder: Mady Browaaeys Fund, Funder: Miriam Marks Brain Research UK, Funder: Bluefield Project, OBJECTIVE: To investigate the optimal method of adding motor features to a clinical rating scale for frontotemporal dementia (FTD). METHODS: Eight hundred and thirty-two participants from the international multicentre Genetic FTD Initiative (GENFI) study were recruited: 522 mutation carriers (with C9orf72, GRN and MAPT mutations) and 310 mutation-negative controls. A standardised clinical questionnaire was used to assess eight motor symptoms (dysarthria, dysphagia, tremor, slowness, weakness, gait disorder, falls and functional difficulties using hands). Frequency and severity of each motor symptom was assessed, and a principal component analysis (PCA) was performed to identify how the different motor symptoms loaded together. Finally, addition of a motor component to the CDR® plus NACC FTLD was investigated (CDR® plus NACC FTLD-M). RESULTS: 24.3% of mutation carriers had motor symptoms (31.7% C9orf72, 18.8% GRN, 19.3% MAPT) compared to 6.8% of controls. Slowness and gait disorder were the commonest in all genetic groups while tremor and falls were the least frequent. Symptom severity scores were similar to equivalent physical motor examination scores. PCA revealed that all motor symptoms loaded together so a single additional motor component was added to the CDR® plus NACC FTLD to form the CDR® plus NACC FTLD-M. Individual global scores were more severe with the CDR® plus NACC FTLD-M, and no patients with a clinically diagnosed motor disorder (ALS/FTD-ALS or parkinsonism) were classified anymore as asymptomatic (unlike the CDR® plus NACC FTLD alone). CONCLUSIONS: Motor features are present in mutation carriers at all disease stages across all three genetic groups. Inclusion of motor symptoms in a rating scale that can be used in future clinical trials will not only ensure a more accurate severity measure is recorded but that a wider spectrum of FTD phenotypes can be included in the same trial.
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- 2022
12. Comparing two picture naming tasks in Primary Progressive Aphasia: insights from behavioural and neural results
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Polito, C., primary, Conca, F., additional, Santi, G.C., additional, Esposito, V., additional, Caminiti, S.P., additional, Boccalini, C., additional, Berti, V., additional, Morinelli, C., additional, Mazzeo, S., additional, Marcone, A., additional, Iannaccone, S., additional, Bessi, V., additional, Sorbi, S., additional, Perani, D., additional, Cappa, S.F., additional, and Catricalà, E., additional
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- 2023
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13. KS-01.3 - REVIEW OF METHODS AND SOFTWARE FOR PATIENTS AND FETAL DOSE ASSESSMENT
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Cannatà, V., Ciucci, D., Donatiello, S., Napolitano, A., and Polito, C.
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- 2023
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14. PD-03.1 - GFR DETERMINATION FROM PLASMA CLEARANCE CURVE: A SIMPLIFIED PROCEDURE USING BLOOD SAMPLES AND HAEMATOCRIT
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Ciucci, D., Camillocci, E. Solfaroli, Palmieri, D., Donatiello, S., Napolitano, A., Polito, C., Villani, M.F., Pizzoferro, M., Altini, C., Garganese, M.C., and Cannatà, V.
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- 2023
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15. CO-08.6 - DOSE EVALUATION FOR 177LU-PRRT RADIATION SAFETY IN PAEDIATRIC PATIENTS
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Camillocci, E. Solfaroli, Ciucci, D., Altini, C., Donatiello, S., Napolitano, A., Palmieri, D., Pizzoferro, M., Polito, C., Villani, M.F., Garganese, M.C., and Cannatà, V.
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- 2023
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16. ‘Frequently recurring’ nocturnal polyuria is predictive of response to desmopressin in monosymptomatic nocturnal enuresis in childhood
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Marzuillo, P., Marotta, R., Guarino, S., Fedele, M.C., Palladino, F., Capalbo, D., Della Vecchia, N., Miraglia del Giudice, E., Polito, C., and La Manna, A.
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- 2019
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17. Looking at my body. Similarities and differences between anorexia nervosa patients and controls in body image visual processing
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Castellini, G., Polito, C., Bolognesi, E., D’Argenio, A., Ginestroni, A., Mascalchi, M., Pellicanò, G., Mazzoni, L.N., Rotella, F., Faravelli, C., Pupi, A., and Ricca, V.
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- 2013
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18. Neural correlates of naming errors across different neurodegenerative diseases: An FDG-PET study
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Catricala, E, Polito, C, Presotto, L, Esposito, V, Sala, A, Conca, F, Gasparri, C, Berti, V, Filippi, M, Pupi, A, Sorbi, S, Iannaccone, S, Magnani, G, Cappa, S, Perani, D, Catricala E., Polito C., Presotto L., Esposito V., Sala A., Conca F., Gasparri C., Berti V., Filippi M., Pupi A., Sorbi S., Iannaccone S., Magnani G., Cappa S. F., Perani D., Catricala, E, Polito, C, Presotto, L, Esposito, V, Sala, A, Conca, F, Gasparri, C, Berti, V, Filippi, M, Pupi, A, Sorbi, S, Iannaccone, S, Magnani, G, Cappa, S, Perani, D, Catricala E., Polito C., Presotto L., Esposito V., Sala A., Conca F., Gasparri C., Berti V., Filippi M., Pupi A., Sorbi S., Iannaccone S., Magnani G., Cappa S. F., and Perani D.
- Abstract
OBJECTIVE: To investigate the types of errors produced in a picture naming task by patients with neurodegenerative dementia due to different etiologies and their neural correlates. METHODS: The same standardized picture naming test was administered to a consecutive sample of patients (n = 148) who had been studied with [18F] FDG-PET. The errors were analyzed in 3 categories (visual, semantic, and phonologic). The PET data were analyzed using an optimized single-subject procedure, and the statistical parametric mapping multiple regression design was used to explore the correlation between each type of error and brain hypometabolism in the whole group. Metabolic connectivity analyses were run at the group level on 7 left hemisphere cortical areas corresponding to an a priori defined naming network. RESULTS: Semantic errors were predominant in most patients, independent of clinical diagnosis. In the whole group analysis, visual errors correlated with hypometabolism in the right inferior occipital lobe and in the left middle occipital lobe. Semantic errors correlated with hypometabolism in the left fusiform gyrus, the inferior and middle temporal gyri, and the temporal pole. Phonologic errors were associated with hypometabolism in the left superior and middle temporal gyri. Both positive (occipital-posterior fusiform) and negative (anterior fusiform gyrus and the superior anterior temporal lobe) connectivity changes were associated with semantic errors. CONCLUSIONS: Naming errors reflect the dysfunction of separate stages of the naming process and are specific markers for different patterns of brain involvement. These correlations are not limited to primary progressive aphasia but extend to other neurodegenerative dementias.
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- 2020
19. Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia
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Panman, J. L., Venkatraghavan, V., Van Der Ende, E. L., Steketee, R. M. E., Jiskoot, L. C., Poos, J. M., Dopper, E. G. P., Meeter, L. H. H., Kaat, L. D., Rombouts, S. A. R. B., Vernooij, M. W., Kievit, A. J. A., Premi, E., Cosseddu, M., Bonomi, E., Olives, J., Rohrer, J. D., Sanchez-Valle, R., Borroni, B., Bron, E. E., Van Swieten, J. C., Papma, J. M., Klein, S., Afonso, S., Almeida, M. R., Anderl-Straub, S., Andersson, C., Antonell, A., Archetti, S., Arighi, A., Balasa, M., Barandiaran, M., Bargallo, N., Bartha, R., Bender, B., Black, S., Butler, C., Bocchetta, M., Borrego-Ecija, S., Bras, J., Bruffaerts, R., Caroppo, P., Cash, D., Castelo-Branco, M., Convery, R., Cope, T., Danek, A., De Arriba, M., De Mendonca, A., Di Fede, G., Diaz, Z., Ducharme, S., Duro, D., Fenoglio, C., Ferreira, C. B., Finger, E., Flanagan, T., Fox, N., Freedman, M., Fumagalli, G., Gabilondo, A., Galimberti, D., Gasparotti, R., Gauthier, S., Gazzina, S., Gerhard, A., Giaccone, G., Gorostidi, A., Graff, C., Greaves, C., Guerreiro, R., Heller, C., Hoegen, T., Indakoetxea, B., Jelic, V., Karnath, H. -O., Keren, R., Laforce, R., Leitao, M. J., Levin, J., Llado, A., Loosli, S., Maruta, C., Masellis, M., Mead, S., Miltenberger, G., Van Minkelenm Sara Mitchell, R., Moore, K., Moreno, F., Nicholas, J., Oijerstedt, L., Otto, M., Ourselin, S., Padovani, A., Peakman, G., Pijnenburg, Y., Polito, C., Prioni, S., Prix, C., Rademakers, R., Redaelli, V., Rittman, T., Rogaeva, E., Rosa-Neto, P., Rossi, G., Rosser, M., Rowe, J., Santana, I., Santiago, B., Scarpini, E., Schonecker, S., Shafei, E. S. R., Shoesmith, C., Synofzik, M., Tabuas-Pereira, M., Tagliavini, F., Tartaglia, C., Tainta, M., Taipa, R., Tang-Wai, D., Thomas, D. L., Thonberg, H., Timberlake, C., Tiraboschi, P., Todd, E., Vandamme, P., Vandenberghe, R., Vandenbulcke, M., Veldsman, M., Verdelho, A., Villanua, J., Warren, J., Wilkeione, C., Elisabeth, W., Henrik, W., Zulaica, Z. M., Neurology, Physics and medical technology, Radiology & Nuclear Medicine, Clinical Genetics, and Medical Research Council
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Male ,Oncology ,Disease ,Neuropsychological Tests ,GENFI consortium investigators ,Primary progressive aphasia ,Cognition ,Progranulins ,0302 clinical medicine ,Neurofilament Proteins ,BEHAVIORAL VARIANT ,HETEROGENEITY ,Gray Matter ,11 Medical and Health Sciences ,Language ,Psychiatry ,0303 health sciences ,Brain ,Middle Aged ,Magnetic Resonance Imaging ,White Matter ,17 Psychology and Cognitive Sciences ,ALZHEIMERS-DISEASE ,Psychiatry and Mental health ,Phenotype ,medicine.anatomical_structure ,Frontotemporal Dementia ,Disease Progression ,Biomarker (medicine) ,Female ,Life Sciences & Biomedicine ,Frontotemporal dementia ,medicine.medical_specialty ,Clinical Neurology ,EVENT-BASED MODEL ,Grey matter ,Lateralization of brain function ,White matter ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Internal medicine ,NEUROFILAMENT LIGHT-CHAIN ,medicine ,Humans ,LOBAR DEGENERATION ,PROGRANULIN ,Aged ,030304 developmental biology ,Science & Technology ,Neurology & Neurosurgery ,business.industry ,DISEASE PROGRESSION ,medicine.disease ,Mutation ,WHITE-MATTER INTEGRITY ,Surgery ,Neurosciences & Neurology ,Neurology (clinical) ,business ,GENFI ,Biomarkers ,030217 neurology & neurosurgery ,Progressive disease - Abstract
ObjectiveProgranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive disease. Modelling the cascade of multimodal biomarker changes aids in understanding the aetiology of this disease and enables monitoring of individual mutation carriers. In this cross-sectional study, we estimated the temporal cascade of biomarker changes for FTD-GRN, in a data-driven way.MethodsWe included 56 presymptomatic and 35 symptomatic GRN mutation carriers, and 35 healthy non-carriers. Selected biomarkers were neurofilament light chain (NfL), grey matter volume, white matter microstructure and cognitive domains. We used discriminative event-based modelling to infer the cascade of biomarker changes in FTD-GRN and estimated individual disease severity through cross-validation. We derived the biomarker cascades in non-fluent variant primary progressive aphasia (nfvPPA) and behavioural variant FTD (bvFTD) to understand the differences between these phenotypes.ResultsLanguage functioning and NfL were the earliest abnormal biomarkers in FTD-GRN. White matter tracts were affected before grey matter volume, and the left hemisphere degenerated before the right. Based on individual disease severities, presymptomatic carriers could be delineated from symptomatic carriers with a sensitivity of 100% and specificity of 96.1%. The estimated disease severity strongly correlated with functional severity in nfvPPA, but not in bvFTD. In addition, the biomarker cascade in bvFTD showed more uncertainty than nfvPPA.ConclusionDegeneration of axons and language deficits are indicated to be the earliest biomarkers in FTD-GRN, with bvFTD being more heterogeneous in disease progression than nfvPPA. Our data-driven model could help identify presymptomatic GRN mutation carriers at risk of conversion to the clinical stage.
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- 2021
20. Stylistic design engineering (SDE) to conceptualize a futuristic sports car
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Frizziero L., Donnici G., Liverani A., Santi G. M., Belsito A., Polito C., Sdruccioli M., Frizziero L., Donnici G., Liverani A., Santi G.M., Belsito A., Polito C., and Sdruccioli M.
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3D Printing ,QFD ,Sportcar ,SDE - Abstract
The present work is a case study about the application of the methodology named Stylistic Design Engineering (SDE), that is an approach to develop car design projects in the industrial world. For attending this goal, it was chosen the S-segment car products, category that identifies the sport car as today’s Lotus. The inspiration for the project started from the top model in the past years of the car manufacturer Audi, or the Audi Quattro (1980-1991). This model represented all the time the most advanced technology in the automotive world of the house, and the most important thing was the all-wheel drive, therefore with four-wheel drive. In the following pages will be illustrated the summary of the path that led to the final product following the “instructions” of SDE method.
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- 2021
21. Functional neuroimaging in anorexia nervosa: A clinical approach
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Pietrini, F., Castellini, G., Ricca, V., Polito, C., Pupi, A., and Faravelli, C.
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- 2011
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22. Effective and eye lens dose evaluation in fluoroscopic-guided procedures
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Cignitti, S. Proietti, primary, Anastasio, G., additional, Polito, C., additional, Pressello, M.C., additional, Rauco, R., additional, and Aragno, D., additional
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- 2021
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23. DTI parameters in neonates with hypoxic-ischemic encephalopathy after total body hypothermia.
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Longo, D., Bottino, F., Lucignani, G., Scarciolla, L., Pasquini, L., Rossi Espagnet, M. C., Polito, C., Figà-Talamanca, L., Calbi, G., Savarese, I., Giliberti, P., and Napolitano, A.
- Abstract
MR imaging provides means for discriminating different patterns of Hypoxic-ischemic encephalopathy (HIE) and may distinguish most severe cases from less severe but is unable to predict long-term outcome. Diffusion tensor imaging (DTI) offers information for a more complete characterization of HIE. The purpose of this study is to compare the modifications of DTI parameters in newborns one week and six months following total-body cooling to healthy controls. Forty-seven cooled newborns were studied with MRI, 20 underwent follow-up at 6 months. 12 healthy newborns and nine children at 6 months were enrolled as control groups (HC). Inferior Longitudinal Fasciculus (ILF), Corpus Callosum Fasciculus (CCF), Corticospinal Tract (CST), Optical Tract (OT), Optic Radiation (OR) were generated in all subjects. DTI parameters were evaluated in basal ganglia (BG), thalamus (TH) and tracks. Statistical analysis was performed with MANOVA. In newborns HIE versus HC, there were significantly lower fractional anisotropy (FA) on OR and CST and higher axial diffusivity (AD), apparent diffusion coefficient (ADC) and radial diffusivity (RD) values on CST, BG and TH in HIE-N. At 6 months there were no significant grouping effects. The analysis showed a significant increase of FA, decrease of ADC, AD, RD after 6 months for HIE and HC. We observed modifications of parameter values in HIE newborns vs HC; however normalization of values at 6 months suggests that changes of parameters cannot be considered early biomarkers for evaluation of therapeutic hypothermia in newborns with moderate HIE and normal conventional MRI. [ABSTRACT FROM AUTHOR]
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- 2022
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24. 355 The Role of Noninvasive, End-Tidal Capnography in Out-of-Hospital Sepsis Identification
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Hoke, R., primary, Wells, L., additional, O'Sullivan, J.W., additional, Bloom, I., additional, Kumar, L., additional, Haber, M., additional, Sevransky, J., additional, and Polito, C., additional
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- 2021
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25. Large-Strain Damping of Sands: Parameter Effects
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Doygun, O., primary, Brandes, H. G., additional, and Polito, C. P., additional
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- 2021
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26. Behavioural disorders in Alzheimer's disease: the descriptive and predictive role of brain 18F-fluorodesoxyglucose-positron emission tomography
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Cappelletto, P., Polito, C., Berti, V., Lombardi, G., Lucidi, G., Bessi, V., Sorbi, S., and Ferrari, C.
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Alzheimer's disease ,BPSD ,brain FDG-PET ,dementia ,Aged ,Brain ,Fluorodeoxyglucose F18 ,Humans ,Positron-Emission Tomography ,Retrospective Studies ,Tomography, X-Ray Computed ,Alzheimer Disease ,Problem Behavior - Published
- 2021
27. Patient factors associated with identification of sepsis in the ED☆
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Wilson, D. K., Polito, C. C., Haber, M. J., Yancey, A., II, Martin, G. S., Isakov, A., Anderson, B. J., Kundel, V., and Sevransky, J. E.
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- 2014
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28. Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia
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Altmann, A., Cash, D. M., Bocchetta, M., Heller, C., Reynolds, R., Moore, K., Convery, R. S., Thomas, D. L., Van Swieten, J. C., Moreno, F., Sanchez-Valle, R., Borroni, B., Laforce, R., Masellis, M., Tartaglia, M. C., Graff, C., Galimberti, D., Rowe, J. B., Finger, E., Synofzik, M., Vandenberghe, R., De Mendonca, A., Tagliavini, F., Santana, I., Ducharme, S., Butler, C. R., Gerhard, A., Levin, J., Danek, A., Frisoni, G., Ghidoni, R., Sorbi, S., Otto, M., Ryten, M., Rohrer, J. D., Greaves, C., Peakman, G., Shafei, R., Todd, E., Rossor, M. N., Warren, J. D., Fox, N. C., Zetterberg, H., Guerreiro, R., Bras, J., Nicholas, J., Mead, S., Jiskoot, L., Meeter, L., Panman, J., Papma, J. M., Van Minkelen, R., Pijnenburg, Y., Barandiaran, M., Indakoetxea, B., Gabilondo, A., Tainta, M., De Arriba, M., Gorostidi, A., Zulaica, M., Villanua, J., Diaz, Z., Borrego-Ecija, S., Olives, J., Llado, A., Balasa, M., Antonell, A., Bargallo, N., Premi, E., Cosseddu, M., Gazzina, S., Padovani, A., Gasparotti, R., Archetti, S., Black, S., Mitchell, S., Rogaeva, E., Freedman, M., Keren, R., Tang-Wai, D., Oijerstedt, L., Andersson, C., Jelic, V., Thonberg, H., Arighi, A., Fenoglio, C., Scarpini, E., Fumagalli, G., Cope, T., Timberlake, C., Rittman, T., Shoesmith, C., Bartha, R., Rademakers, R., Wilke, C., Karnarth, H. -O., Bender, B., Bruffaerts, R., Van Damme, P., Vandenbulcke, M., Ferreira, C. B., Miltenberger, G., Maruta, C., Verdelho, A., Afonso, S., Taipa, R., Caroppo, P., Di Fede, G., Giaccone, G., Prioni, S., Redaelli, V., Rossi, G., Tiraboschi, P., Duro, D., Almeida, M. R., Castelo-Branco, M., Leitao, M. J., Tabuas-Pereira, M., Santiago, B., Gauthier, S., Rosa-Neto, P., Veldsman, M., Thompson, P., Langheinrich, T., Prix, C., Hoegen, T., Wlasich, E., Loosli, S., Schonecker, S., Semler, E., Anderl-Straub, S., Benussi, L., Binetti, G., Pievani, M., Lombardi, G., Nacmias, B., Ferrari, C., Bessi, V., Polito, C., Rowe, James [0000-0001-7216-8679], Apollo - University of Cambridge Repository, Medical Research Council, and Genetic FTD Initiative, GENFI
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0301 basic medicine ,Cell type ,Imaging genetics ,Clinical Neurology ,Medizin ,Biology ,Article ,DISEASE ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,atrophy ,C9orf72 ,Gene expression ,medicine ,Astrocytes ,Frontotemporal dementia ,ddc:610 ,10. No inequality ,Gene ,030304 developmental biology ,Genetics ,0303 health sciences ,Science & Technology ,TREM2 ,AcademicSubjects/SCI01870 ,Neurodegeneration ,General Engineering ,C9orf72 Gene ,Neurosciences ,astrocytes ,Genetic FTD Initiative, GENFI ,medicine.disease ,C9orf72 Protein ,030104 developmental biology ,gene expression ,imaging genetics ,Original Article ,AcademicSubjects/MED00310 ,Human medicine ,Neurosciences & Neurology ,Life Sciences & Biomedicine ,030217 neurology & neurosurgery - Abstract
Frontotemporal dementia is a heterogeneous neurodegenerative disorder characterized by neuronal loss in the frontal and temporal lobes. Despite progress in understanding which genes are associated with the aetiology of frontotemporal dementia, the biological basis of how mutations in these genes lead to cell loss in specific cortical regions remains unclear. In this work, we combined gene expression data for 16 772 genes from the Allen Institute for Brain Science atlas with brain maps of grey matter atrophy in symptomatic C9orf72, GRN and MAPT mutation carriers obtained from the Genetic Frontotemporal dementia Initiative study. No significant association was seen between C9orf72, GRN and MAPT expression and the atrophy patterns in the respective genetic groups. After adjusting for spatial autocorrelation, between 1000 and 5000 genes showed a negative or positive association with the atrophy pattern within each individual genetic group, with the most significantly associated genes being TREM2, SSBP3 and GPR158 (negative association in C9Orf72, GRN and MAPT respectively) and RELN, MXRA8 and LPA (positive association in C9Orf72, GRN and MAPT respectively). An overrepresentation analysis identified a negative association with genes involved in mitochondrial function, and a positive association with genes involved in vascular and glial cell function in each of the genetic groups. A set of 423 and 700 genes showed significant positive and negative association, respectively, with atrophy patterns in all three maps. The gene set with increased expression in spared cortical regions was enriched for neuronal and microglial genes, while the gene set with increased expression in atrophied regions was enriched for astrocyte and endothelial cell genes. Our analysis suggests that these cell types may play a more active role in the onset of neurodegeneration in frontotemporal dementia than previously assumed, and in the case of the positively associated cell marker genes, potentially through emergence of neurotoxic astrocytes and alteration in the blood–brain barrier, respectively., Altmann et al. investigated the concordance between spatial cortical gene expression in healthy subjects and atrophy patterns in genetic frontotemporal dementia. They found that elevated gene expression of endothelial cell and astrocyte-related genes in regions with atrophy, suggesting a role of these cell types in the aetiology of frontotemporal dementia., Graphical Abstract Graphical Abstract
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- 2020
29. DTI parameters in neonates with hypoxic-ischemic encephalopathy after total body hypothermia
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Longo, D., primary, Bottino, F., additional, Lucignani, G., additional, Scarciolla, L., additional, Pasquini, L., additional, Rossi Espagnet, M. C., additional, Polito, C., additional, Figà-Talamanca, L., additional, Calbi, G., additional, Savarese, I., additional, Giliberti, P., additional, and Napolitano, A., additional
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- 2020
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30. Clinical presentation and natural course of idiopathic hypercalciuria in children
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Polito, C., La Manna, A., Cioce, F., Villani, J., Nappi, B., and Di Toro, R.
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- 2000
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31. PS-7-14 Surgical Outcome after Penile Inversion Vaginoplasty: A Retrospective Study of 102 Transgender Women
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Cocci, A., primary, Morelli, G., additional, Matteucci, V., additional, Grisanti Caroassai, S., additional, Delle Rose, A., additional, Cito, G., additional, Polito, C., additional, Rosi, F., additional, Frediani, D., additional, Durante, J., additional, Di Vico, T., additional, Bartoletti, R., additional, Carini, M., additional, Serni, S., additional, Minervini, A., additional, and Francesca, F., additional
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- 2020
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32. Imaging performance dependence on crystal absorption properties: the CRY018 and CRY019 comparison
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Pellegrini, R., primary, Camera, F., additional, Polito, C., additional, Falconi, R., additional, Bettiol, M., additional, Longo, M., additional, Vincentis, G. De, additional, Indovina, L., additional, Pani, R., additional, and Frantellizzi, V., additional
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- 2020
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33. Characterization of monolithic GAGG:Ce coupled to both PMT and SiPM array for gamma imaging in Nuclear Medicine
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Pani, R., primary, Pergola, A., additional, Bettiol, M., additional, Longo, M., additional, Polito, C., additional, Falconi, R., additional, De Sio, L., additional, Pontico, M., additional, Pani, P., additional, Indovina, L., additional, Vincentis, G. De, additional, Pellegrini, R., additional, and Frantellizzi, V., additional
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- 2020
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34. Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study
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Premi, Enrico, Grassi, Mario, van Swieten John, Galimberti, Daniela, Graff, Caroline, Masellis, Mario, Tartaglia, Carmela, Tagliavini, Fabrizio, Rowe James, B, Laforce, Robert, Finger, Elizabeth, Frisoni Giovanni, B, de Mendonça Alexandre, Sorbi, Sandro, Gazzina, Stefano, Cosseddu, Maura, Archetti, Silvana, Gasparotti, Roberto, Manes, Marta, Alberici, Antonella, Cardoso Manuel, J, Bocchetta, Martina, Cash David, M, Ourselin, Sebastian, Padovani, Alessandro, Rohrer Jonathan, D, Andersson, C, Arighi, A, Benussi, L, Binetti, G, Black, S, Dick, K, Fallström, M, Ferreira, C, Fenoglio, C, Fox, N, Freedman, M, Fumagalli, G, Ghidoni, R, Grisoli, M, Jelic, V, Jiskoot, L, Keren, R, Lombardi, G, Maruta, C, Meeter, L, Miltenberger-Miltényi, G, Nacmias, B, Öijerstedt, L, Panman, J, Pievani, M, Polito, C, Prioni, S, Rademakers, R, Redaelli, V, Rogaeva, E, Rossi, G, Rossor, M, Scarpini, E, Tang-Wai, D, Thomas, D, Thonberg, H, Tiraboschi, P, van Minkelen, R, Verdelho, A, Warren, J, Borroni, Barbara, Rowe, James [0000-0001-7216-8679], Apollo - University of Cambridge Repository, and Neurology
- Subjects
Male ,0301 basic medicine ,Oncology ,frontotemporal dementia ,Cognitive reserve ,Frontotemporal dementia ,Genetics ,Structural MRI ,TMEM106b ,Cohort Studies ,ddc:616.89 ,0302 clinical medicine ,C9orf72 ,genetics ,Gray Matter ,10. No inequality ,medicine.diagnostic_test ,Middle Aged ,cognitive reserve ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,structural MRI ,Brain size ,Educational Status ,Female ,Psychology ,Adult ,medicine.medical_specialty ,Genotype ,Prodromal Symptoms ,Nerve Tissue Proteins ,Grey matter ,03 medical and health sciences ,Internal medicine ,mental disorders ,medicine ,Humans ,Dementia ,Cerebral atrophy ,Polymorphism, Genetic ,Mini–Mental State Examination ,Membrane Proteins ,Original Articles ,medicine.disease ,Editor's Choice ,030104 developmental biology ,Neurology (clinical) ,Atrophy ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Frontotemporal dementia (FTD) shows substantial phenotypic variability. In a multicentre study, Premi et al. explore the effect of cognitive reserve and TMEM106B genotype in modulating grey matter volume in presymptomatic FTD. Environmental as well as genetic factors affect rates of brain atrophy, suggesting a possible strategy for delaying disease onset., Frontotemporal dementia is a heterogeneous neurodegenerative disorder with around a third of cases having autosomal dominant inheritance. There is wide variability in phenotype even within affected families, raising questions about the determinants of the progression of disease and age at onset. It has been recently demonstrated that cognitive reserve, as measured by years of formal schooling, can counteract the ongoing pathological process. The TMEM106B genotype has also been found to be a modifier of the age at disease onset in frontotemporal dementia patients with TDP-43 pathology. This study therefore aimed to elucidate the modulating effect of environment (i.e. cognitive reserve as measured by educational attainment) and genetic background (i.e. TMEM106B polymorphism, rs1990622 T/C) on grey matter volume in a large cohort of presymptomatic subjects bearing frontotemporal dementia-related pathogenic mutations. Two hundred and thirty-one participants from the GENFI study were included: 108 presymptomatic MAPT, GRN, and C9orf72 mutation carriers and 123 non-carriers. For each subject, cortical and subcortical grey matter volumes were generated using a parcellation of the volumetric T1-weighted magnetic resonance imaging brain scan. TMEM106B genotyping was carried out, and years of education recorded. First, we obtained a composite measure of grey matter volume by graph-Laplacian principal component analysis, and then fitted a linear mixed-effect interaction model, considering the role of (i) genetic status; (ii) educational attainment; and (iii) TMEM106B genotype on grey matter volume. The presence of a mutation was associated with a lower grey matter volume (P = 0.002), even in presymptomatic subjects. Education directly affected grey matter volume in all the samples (P = 0.02) with lower education attainment being associated with lower volumes. TMEM106B genotype did not influence grey matter volume directly on its own but in mutation carriers it modulated the slope of the correlation between education and grey matter volume (P = 0.007). Together, these results indicate that brain atrophy in presymptomatic carriers of common frontotemporal dementia mutations is affected by both genetic and environmental factors such that TMEM106B enhances the benefit of cognitive reserve on brain structure. These findings should be considered in evaluating outcomes in future disease-modifying trials, and support the search for protective mechanisms in people at risk of dementia that might facilitate new therapeutic strategies.
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- 2017
35. Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study
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Mutsaerts, H. J. M. M., Mirza, S. S., Petr, J., Thomas, D. L., Cash, D. M., Bocchetta, M., De Vita, E., Metcalfe, A. W. S., Shirzadi, Z., Robertson, A. D., Tartaglia, M. C., Mitchell, S. B., Black, S. E., Freedman, M., Tang-Wai, D., Keren, R., Rogaeva, E., Van Swieten, J., Laforce, R., Tagliavini, F., Borroni, B., Galimberti, D., Rowe, J. B., Graff, C., Frisoni, G. B., Finger, E., Sorbi, S., De Mendonca, A., Rohrer, J. D., Macintosh, B. J., Masellis, M., Andersson, C., Archetti, S., Arighi, A., Benussi, L., Binetti, G., Cosseddu, M., Dick, K. M., Fallstrom, M., Ferreira, C., Fenoglio, C., Fox, N. C., Fumagalli, G., Gazzina, S., Ghidoni, R., Grisoli, M., Jelic, V., Jiskoot, L., Lombardi, G., Maruta, C., Mead, S., Meeter, L., Van Minkelen, R., Nacmias, B., Oijerstedt, L., Ourselin, S., Padovani, A., Panman, J., Pievani, M., Polito, C., Premi, E., Prioni, S., Rademakers, R., Redaelli, V., Rossi, G., Rossor, M. N., Scarpini, E., Thonberg, H., Tiraboschi, P., Verdelho, A., Warren, J. D., Rowe, James [0000-0001-7216-8679], Apollo - University of Cambridge Repository, Neurology, Amsterdam Neuroscience - Neurodegeneration, and Radiology and Nuclear Medicine
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0301 basic medicine ,Male ,Pathology ,Tau Proteins/genetics ,cerebral blood flow ,Gene mutation ,Neuropsychological Tests ,Arterial spin labelling ,Frontotemporal Dementia/genetics ,0302 clinical medicine ,Progranulins ,C9orf72 ,Brain ,Middle Aged ,Corrigenda ,Magnetic Resonance Imaging ,Cerebral blood flow ,Cerebrovascular Circulation ,Frontotemporal Dementia ,Female ,arterial spin labelling ,Frontotemporal dementia ,Adult ,medicine.medical_specialty ,Heterozygote ,genetic frontotemporal dementia ,presymptomatic biomarker ,C9orf72 Protein/genetics ,tau Proteins ,Progranulins/genetics ,03 medical and health sciences ,Neuroimaging ,mental disorders ,medicine ,Brain/metabolism ,Dementia ,Humans ,Cerebral perfusion pressure ,Aged ,C9orf72 Protein ,business.industry ,Original Articles ,Voxel-based morphometry ,medicine.disease ,arterial spin labeling ,ddc:616.8 ,Genetic frontotemporal dementia ,Presymptomatic biomarker ,030104 developmental biology ,Cross-Sectional Studies ,Mutation ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Cerebrovascular Circulation/genetics - Abstract
Imaging biomarkers are needed to detect early brain changes in presymptomatic carriers harbouring FTD mutations. Using arterial spin labelling-MRI, Mutsaerts, Mirza et al. identify an inverse association between cerebral perfusion in frontotemporoparietal regions and expected age of onset. Cerebral perfusion may be a promising imaging biomarker for presymptomatic genetic FTD., Genetic forms of frontotemporal dementia are most commonly due to mutations in three genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing those at risk. While cerebral blood flow shows differences between frontotemporal dementia and other forms of dementia, there is limited evidence of its utility in presymptomatic stages of frontotemporal dementia. This study aimed to delineate the cerebral blood flow signature of presymptomatic, genetic frontotemporal dementia using a voxel-based approach. In the multicentre GENetic Frontotemporal dementia Initiative (GENFI) study, we investigated cross-sectional differences in arterial spin labelling MRI-based cerebral blood flow between presymptomatic C9orf72, GRN or MAPT mutation carriers (n = 107) and non-carriers (n = 113), using general linear mixed-effects models and voxel-based analyses. Cerebral blood flow within regions of interest derived from this model was then explored to identify differences between individual gene carrier groups and to estimate a timeframe for the expression of these differences. The voxel-based analysis revealed a significant inverse association between cerebral blood flow and the expected age of symptom onset in carriers, but not non-carriers. Regions included the bilateral insulae/orbitofrontal cortices, anterior cingulate/paracingulate gyri, and inferior parietal cortices, as well as the left middle temporal gyrus. For all bilateral regions, associations were greater on the right side. After correction for partial volume effects in a region of interest analysis, the results were found to be largely driven by the C9orf72 genetic subgroup. These cerebral blood flow differences first appeared approximately 12.5 years before the expected symptom onset determined on an individual basis. Cerebral blood flow was lower in presymptomatic mutation carriers closer to and beyond their expected age of symptom onset in key frontotemporal dementia signature regions. These results suggest that arterial spin labelling MRI may be a promising non-invasive imaging biomarker for the presymptomatic stages of genetic frontotemporal dementia.
- Published
- 2019
36. Tumor Dosimetry And Radiobiological Study For High-Activity 131I-mIBG Therapy In The Management Of Refractory/Relapsed Neuroblastoma
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Polito, C, Cassano, B, Genovese, E, Longo, M, Donatiello, S, Insero, T, Valeri, S, Villani, Mf, Castellano, A, Garganese, Mc, and Cannata, V
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- 2019
37. Dosimetric analysis and clinical outcome for patient with High-Risk Neuroblastoma administered with high-activity therapy of 131I-mIBG
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Cassano, B, Polito, C, Genovese, E, Longo, M, Donatiello, S, Napolitano, A, Insero, T, Valeri, S, Villani, Mf, Castellano, A, Garganese, Mc, and Cannata, V
- Published
- 2019
38. Life quality improvement in Pediatric Patients submitted to Radioiodine Therapy for a return to daily life As Fast As Reasonably Achievable
- Author
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Pizzoferro, M, Polito, C, Cassano, B, Villani, Mf, Longo, M, Genovese, E, Castellano, A, Grossi, A, and Garganese, Mc
- Published
- 2019
39. Preliminary dosimetric study with 177-Lutetium Peptide Receptor Radionuclide Therapy for Pediatric Patients with neuroendocrine tumors
- Author
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Cassano, B, Genovese, E, Polito, C, Longo, M, Donatiello, S, Napolitano, A, Insero, T, Valeri, S, Pizzoferro, M, Serra, A, Garganese, Mc, and Cannata, V
- Published
- 2019
40. Altered body water distribution in subjects with juvenile rheumatoid arthritis and its effects on the measurement of water compartments from bioelectric impedance
- Author
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Bedogni, G., Polito, C., Severi, S., Strano, C.G., Manzieri, A.M., Alessio, M., Iovene, A., and Battistini, N.
- Subjects
Impedance, Bioelectric -- Usage ,Water in the body -- Measurement ,Rheumatoid arthritis in children -- Physiological aspects - Abstract
Bioelectric impedance analysis for predicting the total body water (TBW) and extracellular water (ECW) gives incorrect results for juvenile rheumatoid arthritis patients (JRA) due to their altered body water distribution. A formula which depends on the ratio of ECW to intracellular water (ICW) is developed using a sample of healthy children. JRA patients have a higher TBW% and ECW:ICW ratio due to chronic inflammation and malnutrition. Population-specific formulae that incorporate these differences in TCW and ECW:ICW give more accurate results for JRA patients.
- Published
- 1996
41. Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort
- Author
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Cury, C. (Claire), Durrleman, S. (Stanley), Cash, D.M. (David M.), Lorenzi, M. (Marco), Nicholas, J.M. (Jennifer M.), Bocchetta, M. (Martina), Swieten, J.C. (John) van, Borroni, B. (Barbara), Galimberti, D. (Daniela), Masellis, M. (Mario), Tartaglia, M.C. (Maria Carmela), Rowe, J.B. (James), Graff, C. (Caroline), Tagliavini, F. (Fabrizio), Frisoni, G.B. (Giovanni B.), Laforce, R. (Robert), Finger, E. (Elizabeth), De Mendonça, A. (Alexandre), Sorbi, S. (Sandro), Ourselin, S. (Sebastien), Rohrer, J.D. (Jonathan D.), Modat, M. (Marc), Andersson, C. (Christin), Archetti, S. (Silvana), Arighi, A. (Andrea), Benussi, L. (Luisa), Black, S. (Sandra), Cosseddu, M. (Maura), Fallstrm, M. (Marie), Ferreira, C. (Carlos), Fenoglio, C. (Chiara), Fox, N. (Nick), Freedman, M. (Morris), Fumagalli, G. (Giorgio), Gazzina, S. (Stefano), Ghidoni, R. (Roberta), Grisoli, M. (Marina), Jelic, V. (Vesna), Jiskoot, L.C. (Lize), Keren, R. (Ron), Lombardi, G. (Gemma), Maruta, C. (Carolina), Meeter, L.H.H. (Lieke), Thornton, A.S. (Andrew), Nacmias, B. (Benedetta), ijerstedt, L. (Linn), Padovani, A. (Alessandro), Panman, J. (Jessica), Pievani, M. (Michela), Polito, C. (Cristina), Premi, E. (Enrico), Prioni, S. (Sara), Rademakers, S. (Suzanne), Redaelli, V. (Veronica), Rogaeva, E. (Ekaterina), Rossi, G. (Giacomina), Rossor, M. (Martin), Scarpini, E. (Elio), Tang-Wai, D. (David), Tartaglia, C. (Carmela), Thonberg, H. (Håkan), Tiraboschi, P. (Pietro), Verdelho, A. (Ana), Warren, J. (Jason), Cury, C. (Claire), Durrleman, S. (Stanley), Cash, D.M. (David M.), Lorenzi, M. (Marco), Nicholas, J.M. (Jennifer M.), Bocchetta, M. (Martina), Swieten, J.C. (John) van, Borroni, B. (Barbara), Galimberti, D. (Daniela), Masellis, M. (Mario), Tartaglia, M.C. (Maria Carmela), Rowe, J.B. (James), Graff, C. (Caroline), Tagliavini, F. (Fabrizio), Frisoni, G.B. (Giovanni B.), Laforce, R. (Robert), Finger, E. (Elizabeth), De Mendonça, A. (Alexandre), Sorbi, S. (Sandro), Ourselin, S. (Sebastien), Rohrer, J.D. (Jonathan D.), Modat, M. (Marc), Andersson, C. (Christin), Archetti, S. (Silvana), Arighi, A. (Andrea), Benussi, L. (Luisa), Black, S. (Sandra), Cosseddu, M. (Maura), Fallstrm, M. (Marie), Ferreira, C. (Carlos), Fenoglio, C. (Chiara), Fox, N. (Nick), Freedman, M. (Morris), Fumagalli, G. (Giorgio), Gazzina, S. (Stefano), Ghidoni, R. (Roberta), Grisoli, M. (Marina), Jelic, V. (Vesna), Jiskoot, L.C. (Lize), Keren, R. (Ron), Lombardi, G. (Gemma), Maruta, C. (Carolina), Meeter, L.H.H. (Lieke), Thornton, A.S. (Andrew), Nacmias, B. (Benedetta), ijerstedt, L. (Linn), Padovani, A. (Alessandro), Panman, J. (Jessica), Pievani, M. (Michela), Polito, C. (Cristina), Premi, E. (Enrico), Prioni, S. (Sara), Rademakers, S. (Suzanne), Redaelli, V. (Veronica), Rogaeva, E. (Ekaterina), Rossi, G. (Giacomina), Rossor, M. (Martin), Scarpini, E. (Elio), Tang-Wai, D. (David), Tartaglia, C. (Carmela), Thonberg, H. (Håkan), Tiraboschi, P. (Pietro), Verdelho, A. (Ana), and Warren, J. (Jason)
- Abstract
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. In this paper we propose a spatiotemporal analysis pipeline based on Large Diffeomorphic Deformation Metric Mapping (LDDMM) to detect shape changes from volumetric MRI scans. We applied our framework to a cohort of individuals with genetic variants of frontotemporal dementia and healthy controls from the Genetic FTD Initiative (GENFI) study. Our method, take full advantage of the LDDMM framework, and relies on the creation of a population specific average spatiotemporal trajectory of a relevant brain structure of interest, the thalamus in our case. The residuals from each patient data to the average spatiotemporal trajectory are then clustered and studied to assess when presymptomatic mutation carriers differ from healthy control subjects. We found statistical differences in shape in the anterior region of the thalamus at least five years before the mutation carrier subjects develop any clinical symptoms. This region of the thalamus has been shown to be predominantly connected to the frontal lobe, consistent with the pattern of cortical atrophy seen in the disease.
- Published
- 2019
- Full Text
- View/download PDF
42. Idiopathic hypercalciuria and hyperuricosuria: family prevalence of nephrolithiasis
- Author
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Polito, C., La Manna, A., Nappi, B., Villani, J., and Di Toro, R.
- Published
- 2000
- Full Text
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43. Cyclic voiding cystourethrography in the diagnosis of occult vesicoureteric reflux
- Author
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Polito, C., Moggio, G., La Manna, A., Cioce, F., Cappabianca, S., and Di Toro, R.
- Published
- 2000
- Full Text
- View/download PDF
44. Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)
- Author
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Mutsaerts, H. J. M. M., Petr, J., Thomas, D. L., De Vita, E., Cash, D. M., van Osch, M. J. P., Golay, X., Groot, P. F. C., Ourselin, S., van Swieten, J., Laforce, R., Tagliavini, F., Borroni, B., Galimberti, D., Rowe, J. B., Graff, C., Pizzini, F. B., Finger, E., Sorbi, S., Castelo Branco, M., Rohrer, J. D., Masellis, M., Macintosh, B. J., Rossor, M., Fox, N., Warren, J., Bocchetta, M., Dick, K., Pievani, M., Ghidoni, R., Benussi, L., Padovani, A., Cosseddu, M., Mendonca, A., Frisoni, G., Premi, E., Archetti, S., Scarpini, E., Fumagalli, G., Arighi, A., Fenoglio, C., Prioni, S., Redaelii, V., Grisoli, M., Tiraboschi, P., Black, S., Rogaeva, E., Freedman, M., Tartaglia, M. C., Tang-Wai, D., Keren, R., Panman, J., Meeter, L., Jiskoot, L., van Minkelen, R., Lombardi, G., Polito, C., Nacmias, B., Jelic, V., Andersson, C., Oijerstedt, L., Fallstrom, M., Thonberg, H., Verdelho, A., Maruta, C., Neurology, Mutsaerts, Henri JMM [0000-0003-0894-0307], Apollo - University of Cambridge Repository, and Other departments
- Subjects
Adult ,Male ,cerebral blood flow ,Brain ,Reproducibility of Results ,Arteries ,Middle Aged ,arterial spin labeling ,Magnetic Resonance Imaging ,Article ,Perfusion ,image registration ,Young Adult ,Imaging, Three-Dimensional ,Cerebrovascular Circulation ,Frontotemporal Dementia ,Image Processing, Computer-Assisted ,Humans ,Female ,Spin Labels ,Gray Matter - Abstract
PURPOSE: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. MATERIALS AND METHODS: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking). In addition to visual comparison, we quantified image similarity using the Pearson correlation coefficient (CC), and used the Mann-Whitney U rank sum test. RESULTS: CBF-pGM outperformed M0-T1w (CC improvement 47.2% ± 22.0%; P < 0.001), and the non-rigid transformation outperformed rigid-body (20.6% ± 5.3%; P < 0.001). Masking only improved the M0-T1w rigid-body registration (14.5% ± 15.5%; P = 0.007). CONCLUSION: The choice of image registration strategy impacts ASL group analyses. The non-rigid transformation is promising but requires validation. CBF-pGM rigid-body registration without masking can be used as a default strategy. In patients with expansive perfusion deficits, M0-T1w may outperform CBF-pGM in sequences with high effective spatial resolution. BET-masking only improves M0-T1w registration when the M0 image has sufficient contrast. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:131-140.
- Published
- 2018
- Full Text
- View/download PDF
45. Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
- Author
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Young, A. L., Marinescu, R. V., Oxtoby, N. P., Bocchetta, M., Yong, K., Firth, N. C., Cash, D. M., Thomas, D. L., Dick, K. M., Cardoso, J., van Swieten, J., Borroni, B., Galimberti, D., Masellis, M., Tartaglia, M. C., Rowe, J. B., Graff, C., Tagliavini, F., Frisoni, G. B., Laforce, R., Finger, E., de Mendonca, A., Sorbi, S., Warren, J. D., Crutch, S., Fox, N. C., Ourselin, S., Schott, J. M., Rohrer, J. D., Alexander, D. C., Andersson, C., Archetti, S., Arighi, A., Benussi, L., Binetti, G., Black, S., Cosseddu, M., Fallstrom, M., Ferreira, C., Fenoglio, C., Freedman, M., Fumagalli, G. G., Gazzina, S., Ghidoni, R., Grisoli, M., Jelic, V., Jiskoot, L., Keren, R., Lombardi, G., Maruta, C., Meeter, L., Mead, S., van Minkelen, R., Nacmias, B., Oijerstedt, L., Padovani, A., Panman, J., Pievani, M., Polito, C., Premi, E., Prioni, S., Rademakers, R., Redaelli, V., Rogaeva, E., Rossi, G., Rossor, M., Scarpini, E., Tang-Wai, D., Thonberg, H., Tiraboschi, P., Verdelho, A., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., Khachaturian, Z., Sorensen, G., Kuller, L., Raichle, M., Paul, S., Davies, P., Fillit, H., Hefti, F., Holtzman, D., Mesulam, M. M., Potter, W., Snyder, P., Schwartz, A., Montine, T., Thomas, R. G., Donohue, M., Walter, S., Gessert, D., Sather, T., Jiminez, G., Harvey, D., Bernstein, M., Thompson, P., Schuff, N., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Landau, S., Cairns, N. J., Householder, E., Taylor-Reinwald, L., Lee, V., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Faber, K., Kim, S., Nho, K., Thal, L., Buckholtz, N., Albert, M., Frank, R., Hsiao, J., Kaye, J., Quinn, J., Lind, B., Carter, R., Dolen, S., Schneider, L. S., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B. M., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J. L., Lord, J. L., Mason, S. S., Albers, C. S., Knopman, D., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L. S., Bell, K. L., Ances, B., Carroll, M., Leon, S., Mintun, M. A., Schneider, S., Oliver, A., Marson, D., Griffith, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Grossman, H., Mitsis, E., de Toledo-Morrell, L., Shah, R. C., Duara, R., Varon, D., Greig, M. T., Roberts, P., Onyike, C., D'Agostino, D., Kielb, S., Galvin, J. E., Cerbone, B., Michel, C. A., Rusinek, H., de Leon, M. J., Glodzik, L., De Santi, S., Doraiswamy, P. M., Petrella, J. R., Wong, T. Z., Arnold, S. E., Karlawish, J. H., Wolk, D., Smith, C. D., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Lopez, O. L., Oakley, M. A., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Mulnard, R. A., Thai, G., Mc-Adams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Diaz-Arrastia, R., King, R., Weiner, M., Martin-Cook, K., Devous, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Anderson, H. S., Swerdlow, R. H., Apostolova, L., Tingus, K., Woo, E., Silverman, D. H., P. H., Lu, Bartzokis, G., Graff-Radford, N. R., Parfitt, F., Kendall, T., Johnson, H., Farlow, M. R., Hake, A. M., Matthews, B. R., Herring, S., Hunt, C., van Dyck, C. H., Carson, R. E., Macavoy, M. G., Chertkow, H., Bergman, H., Hosein, C., Stefanovic, B., Caldwell, C., Hsiung, G. -Y. R., Feldman, H., Mudge, B., Assaly, M., Kertesz, A., Rogers, J., Bernick, C., Munic, D., Kerwin, D., Mesulam, M. -M., Lipowski, K., C. -K., Wu, Johnson, N., Sadowsky, C., Martinez, W., Villena, T., Turner, R. S., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Frey, M., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M. N., Belden, C. M., Jacobson, S. A., Sirrel, S. A., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Allard, J., Lerner, A., Ogrocki, P., Hudson, L., Fletcher, E., Carmichael, O., Olichney, J., Decarli, C., Kittur, S., Borrie, M., Lee, T. -Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C. M., Potkin, S. G., Preda, A., Nguyen, D., Tariot, P., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Adeli, A., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Santulli, R. B., Kitzmiller, T. J., Schwartz, E. S., Sink, K. M., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Mintzer, J., Spicer, K., Bachman, D., Pasternak, S., Rachinsky, I., Drost, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Ponto, L. L. B., Shim, H., Smith, K. E., Relkin, N., Chaing, G., Raudin, L., Smith, A., Fargher, K., Raj, B. A., Neylan, T., Grafman, J., Davis, M., Morrison, R., Hayes, J., Finley, S., Friedl, K., Fleischman, D., Arfanakis, K., James, O., Massoglia, D., Fruehling, J. J., Harding, S., Peskind, E. R., Petrie, E. C., Li, G., Yesavage, J. A., Taylor, J. L., and Furst, A. J.
- Published
- 2018
46. Combined positivity for P63 and ERG in intraductal carcinoma of the prostate
- Author
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Tognarelli, A., Di Vico, T., Durante, J., Polito, C., Meneghetti, I., Tesi, L., Baldesi, R., PINUCCIA FAVIANA, and Riccardo Bartoletti
- Published
- 2018
47. Safety of collagenase clostridium hystolyticum in patients affected by peyronie’s disease under anti-platelets or anti-coagulants
- Author
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Laruccia, N., primary, Mondaini, N., additional, Cito, G., additional, Polito, C., additional, Gemma, L., additional, Di Costanzo, R., additional, Verrienti, P., additional, Russo, G., additional, Di Maida, F., additional, Falcone, M., additional, Polloni, G., additional, Serni, S., additional, Mari, A., additional, Campi, R., additional, Minervini, A., additional, Giammusso, B., additional, Verze, P., additional, Capece, M., additional, Salonia, A., additional, and Cocci, A., additional
- Published
- 2019
- Full Text
- View/download PDF
48. Impact of Re-usable surgical drapes on perioperative wound and systemic infections
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Lencioni, M., primary, Durante, J., additional, Di Vico, T., additional, Tesi, L., additional, Tognarelli, A., additional, Meneghetti, I., additional, Polito, C., additional, Brizzi, L., additional, Malloggi, S., additional, Perotti, A., additional, Bracchitta, D., additional, and Bartoletti, R., additional
- Published
- 2019
- Full Text
- View/download PDF
49. Novel Gamma Tracker for Rapid Radiation Direction Detection for UAV Drone Use
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Pani, R., primary, Camera, F., additional, Pergola, A., additional, Polito, C., additional, Falconi, R., additional, Franciosini, G., additional, Longo, M., additional, Bettiol, M., additional, Frantellizzi, V., additional, Vincentis, G. De, additional, and Pani, A., additional
- Published
- 2019
- Full Text
- View/download PDF
50. Front Line of Sepsis Care: Training Emergency Medical Services Providers to Identify Sepsis Using a Validated Sepsis Screening Tool
- Author
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Sayad, K., primary, Rajasekar, S., additional, Mohsin, A., additional, Nabavi, N., additional, Yancey II, A., additional, Sevransky, J.E., additional, and Polito, C., additional
- Published
- 2019
- Full Text
- View/download PDF
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