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5. Interleukin-1 Signaling and Alcohol-Induced Cortical Dysfunction

Author

Varodayan, Florence P., primary, Pahng, A.R., additional, Davis, T.D., additional, Nadav, T., additional, Polis, I., additional, Cates-Gatto, C.C., additional, Bajo, M., additional, Burkart, M.D., additional, Edwards, S., additional, Roberts, A.J., additional, and Roberto, M., additional

Published
2023
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8. Impact of Adaptive Gastric Electrical Stimulation on Weight, Food Intake, and Food Intake Rate in Dogs

Author

Debelle, Adrien, Hesta, Myriam, de Rooster, Hilde, Bianchini, Erika, Vanhoestenberghe, Anne, Stock, Emmelie, Vanderperren, Katrien, Polis, I., Smets, Hugo, Cury, Joaquin, Acuna Otarola, Vicente, Delchambre, Alain, Innocenti, Bernardo, Devière, Jacques, Nonclercq, Antoine, Debelle, Adrien, Hesta, Myriam, de Rooster, Hilde, Bianchini, Erika, Vanhoestenberghe, Anne, Stock, Emmelie, Vanderperren, Katrien, Polis, I., Smets, Hugo, Cury, Joaquin, Acuna Otarola, Vicente, Delchambre, Alain, Innocenti, Bernardo, Devière, Jacques, and Nonclercq, Antoine

Abstract

Background: Gastric electrical stimulation (GES) has been studied for decades as a promising treatment for obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations with regard to overcoming habituation to GES and inter-subject variation. This study aims to analyze the efficacy of an adaptive GES protocol for reducing food intake and maintaining lean weight in dogs. Methods: Six beagle dogs were implanted with a remotely programmable gastric stimulator. An adaptive protocol was designed to increase the stimulation energy proportionally to the excess of food consumption, with respect to the dogs’ maintenance energy requirements. After surgery and habituation to experimental conditions, the dogs went through both a control and a stimulation period of 4 weeks each, in a randomized order. The stimulation parameters were adapted daily. Body weight, food intake, food intake rate, and postprandial cutaneous electrogastrograms (EGG) were recorded to assess the effect of adaptive GES. Results: Adaptive GES decreased food intake and food intake rate (p < 0.05) resulting in weight maintenance. In the absence of GES, the dogs gained weight (p < 0.05). Postprandial EGG dominant frequency was accelerated by GES (p < 0.05). The strategy of adapting the stimulation energy was effective in causing significant mid-term changes. Conclusion: Adaptive GES is effective for reducing food intake and maintaining lean weight. The proposed adaptive strategy may offer benefits to counter habituation and adapt to inter-subject variation in clinical use of GES for obesity., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

22. Clinical and electrophysiological characterization of myokymia and neuromyotonia in Jack Russell Terriers

Author

Vanhaesebrouck, AE, Van Soens, I, Poncelet, L, Duchateau, L, Bhatti, S, Polis, I, Diels, S, Van Ham, L, Vanhaesebrouck, An [0000-0003-1721-6169], and Apollo - University of Cambridge Repository

Subjects
Male, Dogs, Neural Conduction, Animals, Female, Myokymia, Dog Diseases, Isaacs Syndrome, Electrophysiological Phenomena
Abstract

BACKGROUND: Generalized myokymia and neuromyotonia (M/NM) in Jack Russell Terriers (JRTs) is related to peripheral nerve hyperexcitability syndrome in humans, a symptom complex resulting from diverse etiologies. OBJECTIVE: Clinical and electrodiagnostic evaluation is used to narrow the list of possible etiological diagnoses in JRTs with M/NM. ANIMALS: Nine healthy JRTs and 8 affected JRTs. METHODS: A prospective study was conducted comparing clinical and electrophysiological characteristics in 8 JRTs affected by M/NM with 9 healthy JRT controls. RESULTS: All affected dogs except 1 had clinical signs typical of hereditary ataxia (HA). In 6 dogs, neuromyotonic discharges were recorded during electromyogram. Motor nerve conduction studies showed an axonal neuropathy in only 1 affected dog. Compared with controls, brainstem auditory-evoked potentials (BAEP) showed prolonged latencies (P

Published
2019
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28. Immunohistochemical Expression of Potential Therapeutic Targets in Canine Thyroid Carcinoma

Author

Campos, M, Ducatelle, R, Kooistra, H S, Rutteman, G, Duchateau, L, Polis, I, Daminet, S, Sub Endocrinologie, Sub Oncologie/Cytologie, Sub Endocrinologie, and Sub Oncologie/Cytologie

Subjects
p53, Vascular Endothelial Growth Factor A, Pathology, medicine.medical_specialty, Cyclooxygenase‐2, medicine.medical_treatment, Adenocarcinoma, Medullary, Follicular cell, Thyroid carcinoma, chemistry.chemical_compound, Dogs, Adenocarcinoma, Follicular, P‐glycoprotein, Medicine, Animals, ATP Binding Cassette Transporter, Subfamily B, Member 1, Dog Diseases, Thyroid Neoplasms, 630 Agriculture, General Veterinary, business.industry, Carcinoma, Thyroid, Follicular, P-Glycoprotein, Cancer, veterinary, medicine.disease, VEGF, Standard Articles, Vascular endothelial growth factor, medicine.anatomical_structure, Medullary carcinoma, chemistry, Calcitonin, Cyclooxygenase 2, Carcinoma, Medullary, Thyroglobulin, Original Article, Tumor Suppressor Protein p53, business, metabolism
Abstract

Background Thyroid carcinoma is a common endocrine tumor in the dog. Local invasive growth frequently precludes surgical excision and, in up to 38% of dogs, the tumor has already metastasized by the time of diagnosis. Therefore, it is important to investigate new treatment modalities that may be useful for the large number of dogs with inoperable tumors or metastatic disease. Hypothesis/Objectives To investigate the immunohistochemical expression of potential therapeutic targets in canine thyroid tumors. Animals 74 dogs with thyroid neoplasia. Methods Immunohistochemistry was performed for thyroglobulin, calcitonin, vascular endothelial growth factor (VEGF), p53, cycloxygenase-2 (cox-2), and P-glycoprotein (P-gp). Results Fifty-four (73%) tumors were classified as follicular cell thyroid carcinomas (FTCs) and 20 (27%) as medullary thyroid carcinomas (MTCs). Eighty percent of FTCs and all MTCs had a high percentage (76–100%) of neoplastic cells immunopositive for VEGF. Thirteen percent of FTCs and 50% of MTCs expressed cox-2. Seven percent of FTCs and 70% of MTCs expressed P-gp. No tumor was immunopositive for p53 expression. Expression of VEGF (P = .034), cox-2 (P = .013), and P-gp (P

Published
2014

34. Congenital lobar emphysema in a kitten

Author

Blonk, M., primary, Van de Maele, I., additional, Combes, A., additional, Stablay, B., additional, De Cock, H., additional, Polis, I., additional, Rybachuk, G., additional, and de Rooster, H., additional

Published
2017
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40. Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid

Author

De Luca, Maria Antonietta, Bimpisidis, Zisis, Melis, Miriam, Marti, Matteo, Caboni, Pierluigi, Valentini, Valentina, Margiani, G, Pintori, N, Polis, I, Marsicano, Giovanni, Parsons, Larry H, Di Chiara, Gaetano, De Luca, Maria Antonietta, Bimpisidis, Zisis, Melis, Miriam, Marti, Matteo, Caboni, Pierluigi, Valentini, Valentina, Margiani, G, Pintori, N, Polis, I, Marsicano, Giovanni, Parsons, Larry H, and Di Chiara, Gaetano

Published
2015

42. Anesthesia in kittens a review of the literature with stress on the possibilities in Belgium : Anesthesie van kittens een literatuuroverzicht met nadruk op de mogelijkheden in België

Author

Peeters, Els, Porters, N, Bols, PEJ, Nelissen, M, Moons, CPH, de Rooster, H, and Polis, I

Subjects
anesthesie, kitten
Abstract

In Belgium, elective surgical procedures in very young small animals are rarely performed. Consequently, most veterinarians have little experience in anesthetizing pediatric patients. This article describes potential problems of anesthesia in kittens, which are mainly linked to their specific anatomy and physiology. Additionally, some practical anesthetic protocols are highlighted. Combinations with ketamine are practical, economical and efficient options. In België worden zelden electieve chirurgische ingrepen uitgevoerd bij zeer jonge kleine huisdieren. Veel dierenartsen hebben dan ook weinig ervaring met de anesthesie van pediatrische patiënten. In dit overzichtsartikel wordt kort ingegaan op de risicofactoren bij de anesthesie van kittens, gezien hun specifieke anatomie en fysiologie. Vervolgens wordt een overzicht gegeven van geschikte anesthetische protocollen. Injectieanesthesie op basis van combinaties met ketamine is een praktische, economische en efficiënte optie. ispartof: Vlaams Diergeneeskundig Tijdschrift vol:81 issue:3 pages:129-137 status: published

Published
2012

43. Anesthesie van kittens : een overzicht van de mogelijkheden

Author

Peeters, E.H.K.A., Porters, N., Bols, Peter, Nelissen, Mark, Moons, C.P.H., de Rooster, H., and Polis, I.

Subjects
Veterinary medicine
Abstract

In Belgium, elective surgical procedures in very young small animals are rarely performed. Consequently, most veterinarians have little experience in anesthetizing pediatric patients. This article describes potential problems of anesthesia in kittens, which are mainly linked to their specific anatomy and physiology. Additionally, some practical anesthetic protocols are highlighted. Combinations with ketamine are practical, economical and efficient options.

Published
2012

50. Megaesophagus in dogs and cats

Author

Van Ham, A, Vanhaesebrouck, A, Polis, I, Van Ham, L, Vanhaesebrouck, An [0000-0003-1721-6169], and Apollo - University of Cambridge Repository

Published
2009

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