16 results on '"Polidoro D"'
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2. Sonda uretral flexível como método alternativo para aferição invasiva da pressão intracraniana em trauma cranioencefálico induzido em coelhos
- Author
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Aiello, G., primary, Andrades, A.O., additional, Ripplinger, A., additional, Soares, A.V., additional, Polidoro, D., additional, Vaz, M.A.B., additional, Colvero, A.C., additional, Santos, R.P., additional, Conceição, R., additional, Chaves, R.O., additional, and Mazzanti, A., additional
- Published
- 2017
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3. Extrusão de disco intervertebral caudal (coccígea) em um Basset Hound: primeiro relato de caso
- Author
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Polidoro, D., primary, Corrêa, L.F.D., additional, Santos, R.P., additional, Aiello, G., additional, Chaves, R.O., additional, Baumhardt, R., additional, Ripplinger, A., additional, and Mazzanti, A., additional
- Published
- 2017
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4. Immediate physical therapy in dogs with rupture of the cranial cruciate ligament submitted to extracapsular surgical stabilization
- Author
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Berté, L., Mazzanti, A., Salbego, F.Z., Beckmann, D.V., Santos, R.P., Polidoro, D., and Baumhardt, R.
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surgery ,fisioterapia ,trauma ,cão ,dog ,knee ,joelho ,cirurgia ,physiotherapy - Abstract
The study evaluated the influence of immediate physical therapy on the functional recovery of hind limbs of dogs with experimental cranial cruciate ligament rupture which underwent surgical extracapsular stabilization as well as to verify its interference in joint stability. Eight dogs were randomly divided into two groups: GI (control) (n=4) and GII (physical therapy) (n=4). The dogs in GII underwent the following therapeutic treatments in the postoperative period: cryotherapy, passive joint movement, massage, passive straightening, neuromuscular electrical stimulation, hydrotherapy (bath and aquatic mat) and therapeutic exercises. We performed evaluations of the thigh circumference, goniometry, X-ray, and knee stability (drawer test). Results did not demonstrate a significant difference between the groups nor between different post-operative times. Regarding gait analysis, we found that the 4 dogs in GI remained in degree 3 of lameness 45 and 90 days postoperatively. However, in GII, one dog remained in degree 3 45 and 90 days after surgery; one dog changed from degree 3 to 4 90 days after surgery and the other 2 dogs changed from degree 3 to 5 90 days after surgery. It is possible to conclude that dogs with CCL rupture that undergo immediate physical therapy demonstrate better results in regards to functional gait recovery. The therapeutic modalities used in the immediate post-operative period did not cause instability of the operated knee. Further studies are needed with a larger number of dogs to indicate the immediate physical therapy in dogs with CCL ligament rupture which underwent extracapsular stabilization. Avaliou-se a influência da fisioterapia imediata na recuperação funcional do membro pélvico de cães com ruptura experimental do ligamento cruzado cranial (LCC) submetidos à estabilização cirúrgica extracapsular e verificou-se sua interferência na estabilidade articular. Foram utilizados oito cães distribuídos, aleatoriamente, em GI ou controle (n=4) e GII ou fisioterapia (n=4). Nos cães do GII, as modalidades terapêuticas empregadas no pós-operatório foram crioterapia, movimentação passiva da articulação, massagem, alongamento passivo, estimulação elétrica neuromuscular, hidroterapia (ducha e esteira aquática) e exercícios terapêuticos. Foram realizadas avaliações da circunferência da coxa, goniometria, radiografias e estabilidade do joelho (teste de gaveta) e os resultados não demonstraram diferença significativa entre os grupos e nos diferentes tempos de pós-operatório. Na análise da marcha, aos 45 dias, todos os cães do GI e do GII apresentaram grau 3 de claudicação. Aos 90 dias, quatros cães do GI permaneceram em grau 3 e no GII, um cão em grau 3, um em grau 4 e dois em grau 5. Conclui-se que cães com ruptura de LCC submetidos à fisioterapia imediata demonstraram melhores resultados quanto à recuperação funcional da marcha e as modalidades terapêuticas empregadas no pós-operatório imediato não ocasionaram instabilidade do joelho operado. Novas pesquisas são necessárias com um maior número de cães para poder indicar a fisioterapia imediata em cães com ruptura do ligamento cruzado cranial submetidos à estabilização cirúrgica extracapsular.
- Published
- 2012
5. Immediate physical therapy in dogs with rupture of the cranial cruciate ligament submitted to extracapsular surgical stabilization
- Author
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Berté, L., primary, Mazzanti, A., additional, Salbego, F.Z., additional, Beckmann, D.V., additional, Santos, R.P., additional, Polidoro, D., additional, and Baumhardt, R., additional
- Published
- 2012
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6. PILOT STUDY DETERMINING THE FEASIBILITY OF DIAGNOSING PANCREATIC CANCER USING SINGLE CELL PARTIAL WAVE SPECTROSCOPY OF THE DUODENAL MUCOSA
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Subramanian, H., primary, Brand, R., additional, Pradhan, P., additional, Deep, N., additional, Parikh, V., additional, Hasabou, N., additional, Polidoro, D., additional, Sturgis, C., additional, and Backman, V., additional
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- 2007
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7. Diversified upgrading of HMF via acetylation, aldol condensation, carboxymethylation, vinylation and reductive amination reactions
- Author
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Davide Rigo, Daniele Polidoro, Alvise Perosa, Maurizio Selva, Rigo, D., Polidoro, D., Perosa, A., and Selva, M.
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isopropenyl acetate ,vinylation ,Methyl acetate ,Phosphonium salt ,Salt (chemistry) ,Reductive amination ,reductive amination ,Catalysis ,chemistry.chemical_compound ,Vinylation ,dimethyl carbonate ,Acetone ,Tandem reaction ,Organic chemistry ,Physical and Theoretical Chemistry ,carboxymethylation ,acetylation ,chemistry.chemical_classification ,5-hydroxymethylfurfural ,Process Chemistry and Technology ,Settore CHIM/06 - Chimica Organica ,Isopropenyl acetate ,5-hmf ,Dimethyl carbonate ,Tandem reactions ,chemistry ,Aldol condensation ,5-hydroxymethylfurfural, carboxymethylation, acetylation, reductive amination, vinylation, dimethyl carbonate, isopropenyl acetate - Abstract
Multiple sustainable methodologies were developed for the chemical upgrading of HMF: i) at 30–90 °C, highly selective base-catalyzed acetylation and carboxymethylation reactions of HMF with nontoxic reagents as isopropenyl acetate (iPAc) and dimethyl carbonate (DMC) were achieved to prepare the corresponding ester and carbonate products, (5-formylfuran-2-yl)methyl acetate (5-formylfuran-2-yl) methyl carbonate, respectively; ii) based on the combined use of iPAc/DMC with acetone, a tandem protocol of acetylation/transcarbonation and aldol condensation was designed to synthesize a variety of HMF-derived α,β-unsaturated carbonyl compounds; iii) in water as a solvent, a chemoselective Pd-catalysed reductive amination of HMF with amino-alcohols also including glycerol derivatives, was developed using H2 at atmospheric pressure; iv) finally, both HMF and its ester and carbonate products successfully underwent Wittig vinylation reactions promoted by a methyl carbonate phosphonium salt ( [Ph3PCH3] [CH3OCO2]), to obtain the corresponding olefins. The vinylation reagent (the salt) was a DMC derivative. In all cases i-iv), not only processes occurred under mild conditions, but post-reaction procedures (work-up and purification) were optimized to isolate final products in high yields of 85–98%.
- Published
- 2021
8. Controllable deposition of dispersed Pd nanoparticles on ZnO for Suzuki-Miyaura cross-coupling reactions.
- Author
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Bressi V, Len T, Polidoro D, Esposito R, Mazur M, Selva M, Espro C, and Luque R
- Abstract
Palladium nanoparticles find extensive applications in catalysis in both homogeneously and heterogeneously catalyzed processes. Supporting metal nanoparticles enhances their stability as compared to their unsupported counterparts. The role of catalytic support is increasingly recognized as crucial in determining the behaviour of these materials. However, controlling the deposition and anchoring of palladium nanoparticles remains a significant challenge. This contribution discusses the preparation of straight lines of palladium particles on zinc oxide by wet impregnation. This phenomenon is attributed to the highly stepped morphology of the employed ZnO that created steric anchoring sites to stabilize the metal particles. Palladium-based catalysts were evaluated for the valuable Suzuki-Miyaura cross-coupling reaction. The dispersed Pd/ZnO catalyst achieved a conversion rate of 86% with 100% selectivity, remarkably superior to that of the Pd/Al
2 O3 and Pd/TiO2 counterparts.- Published
- 2023
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9. Continuous Flow Hydrogenation of Lignin-model Aromatic Compounds over Carbon-supported Noble Metals.
- Author
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Polidoro D, Selva M, and Luque R
- Abstract
An efficient continuous-flow (CF) protocol was designed for the hydrogenation of lignin-derived aromatics to the corresponding cycloalkanes derivatives. A parametric analysis of the reaction was carried out by tuning the temperature, the H
2 pressure and the flow rate, and using diphenyl ether (DPE) as a model substrate, commercial Ru/C as a catalyst, and isopropanol as a solvent: at 25 °C, 50 bar H2 , and a flow rate of 0.1 mL min-1 , dicyclohexyl ether was achieved in an 86 % selectivity, at quantitative conversion. By-products from the competitive C-O bond cleavage of DPE, cyclohexanol and cyclohexane, did not exceed 14 % in total. Remarkably, prolonged experiments demonstrated an excellent stability of the catalyst whose performance was unaltered for up to 420 min of time-of-stream. A substrate scope evaluation proved that under the same conditions used for DPE, a variety of substrates including alkoxy-, allyl-, and carbonyl-functionalized phenols, biphenyl, aryl benzyl- and phenethyl ethers (10 examples) yielded the ring-hydrogenated products with selectivity up to 99 % at complete conversion., (© 2023 Wiley-VCH Verlag GmbH.)- Published
- 2023
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10. Chitin-Derived Nanocatalysts for Reductive Amination Reactions.
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Polidoro D, Rodriguez-Padron D, Perosa A, Luque R, and Selva M
- Abstract
Chitin, the second most abundant biopolymer in the planet after cellulose, represents a renewable carbon and nitrogen source. A thrilling opportunity for the valorization of chitin is focused on the preparation of biomass-derived N -doped carbonaceous materials. In this contribution, chitin-derived N -doped carbons were successfully prepared and functionalized with palladium metal nanoparticles. The physicochemical properties of these nanocomposites were investigated following a multi-technique strategy and their catalytic activity in reductive amination reactions was explored. In particular, a biomass-derived platform molecule, namely furfural, was upgraded to valuable bi-cyclic compounds under continuous flow conditions.
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- 2023
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11. Metal-Free N -Doped Carbons for Solvent-Less CO 2 Fixation Reactions: A Shrimp Shell Valorization Opportunity.
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Polidoro D, Perosa A, Rodríguez-Castellón E, Canton P, Castoldi L, Rodríguez-Padrón D, and Selva M
- Abstract
High anthropogenic CO
2 emissions are among the main causes of climate change. Herein, we investigate the use of CO2 for the synthesis of organic cyclic carbonates on metal-free nitrogen-doped carbon catalysts obtained from chitosan, chitin, and shrimp shell wastes, both in batch and in continuous flow (CF). The catalysts were characterized by N2 physisorption, CO2 -temperature-programmed desorption, X-ray photoelectron spectroscopy, scanning electron microscopy, and CNHS elemental analysis, and all reactivity tests were run in the absence of solvents. Under batch conditions, the catalyst obtained by calcination of chitin exhibited excellent performance in the conversion of epichlorohydrin (selected as a model epoxide), resulting in the corresponding cyclic carbonate with 96% selectivity at complete conversion, at 150 °C and 30 bar CO2 , for 4 h. On the other hand, in a CF regime, a quantitative conversion and a carbonate selectivity >99% were achieved at 150 °C, by using the catalyst obtained from shrimp waste. Remarkably, the material displayed an outstanding stability over a reaction run time of 180 min. The robustness of the synthetized catalysts was confirmed by their good operational stability and reusability: ca. (75 ± 3)% of the initial conversion was achieved/retained by all systems, after six recycles. Also, additional batch experiments proved that the catalysts were successful on different terminal and internal epoxides., Competing Interests: The authors declare no competing financial interest., (© 2022 American Chemical Society.)- Published
- 2022
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12. Tunable Multi-Phase System for Highly Chemo-Selective Oxidation of Hydroxymethyl-Furfural.
- Author
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Polidoro D, Perosa A, and Selva M
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- Acids, Catalysis, Oxidants, Oxidation-Reduction, Furaldehyde, Furans
- Abstract
Three different multiphase systems (MP 1-3) comprised of two immiscible liquids, with or without an ionic liquid (IL: methyltrioctyl ammonium chloride), were investigated for the oxidation of 5-hydroxymethyl-furfural (HMF) over 5 % Ru/C as a catalyst and air (8 bar) as an oxidant. These conditions proved versatile for an excellent control of the reaction selectivity to 4 distinct products derived from full or partial oxidation of the carbonyl and alcohol functions of HMF, and each one achieved in 87-96 % isolated yield at complete conversion. MP1 based on water and isooctane, yielded 2,5-furandicarboxylic acid (FDCA, 91 % yield). In MP2, obtained by adding the IL to MP1, the oxidation proceeded towards the formation of 5-formyl-2-furancarboxylic acid (FFCA, 87-89 % yield). MP2 also proved successful in the design of a one pot-two step oxidation/reduction sequence to prepare 5-hydroxymethyl-2-furancarboxylic acid (HMFCA, 85 % yield). In MP3, the use of an acetonitrile/cyclooctane biphase yielded 2,5-diformylfuran (DFF, 96 % yield). All the multiphase systems MP 1-3 allowed a perfect segregation of the catalyst in a single phase (either the hydrocarbon or the IL) distinct from the one containing HMF and its oxidation products. This was crucial not only for the catalyst/product separation but also for the recycle of Ru/C that was possible under all the tested conditions. Accordingly, MP-reaction were run in a semicontinuous mode without removing the catalyst from the reactor nor resorting to conventional separation and activation techniques. Negligible Ru leaching, less than 0.96 ppb, was measured in all cases., (© 2022 Wiley-VCH GmbH.)
- Published
- 2022
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13. Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs.
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Polidoro D, Temmerman R, Devreese M, Charalambous M, Ham LV, Cornelis I, Broeckx BJG, Mandigers PJJ, Fischer A, Storch J, and Bhatti SFM
- Abstract
The therapeutic potential of cannabidiol (CBD), a non-psychtropic component of the Cannabis sativa plant, is substantiated more and more. We aimed to determine the pharmacokinetic behavior of CBD after a single dose via intranasal (IN) and intrarectal (IR) administration in six healthy Beagle dogs age 3-8 years old, and compare to the oral administration route (PO). Standardized dosages applied for IN, IR and PO were 20, 100, and 100 mg, respectively. Each dog underwent the same protocol but received CBD through a different administration route. CBD plasma concentrations were determined by ultra-high performance liquid chromatography-tandem mass spectrometry before and at fixed time points after administration. Non-compartmental analysis was performed on the plasma concentration-time profiles. Plasma CBD concentrations after IR administration were below the limit of quantification. The mean area under the curve (AUC) after IN and PO CBD administration was 61 and 1,376 ng/mL*h, respectively. The maximal plasma CBD concentration (C
max ) after IN and PO CBD administration was 28 and 217 ng/mL reached after 0.5 and 3.5 h (Tmax ), respectively. Significant differences between IN and PO administration were found in the Tmax ( p = 0.04). Higher AUC and Cmax were achieved with 100 mg PO compared to 20 mg IN, but no significant differences were found when AUC ( p = 0.09) and Cmax ( p = 0.44) were normalized to 1 mg dosages. IN administration of CBD resulted in faster absorption when compared to PO administration. However, PO remains the most favorable route for CBD delivery due to its more feasible administration. The IR administration route is not advised for clinical application., Competing Interests: JS was employed by company CBDepot. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Polidoro, Temmerman, Devreese, Charalambous, Ham, Cornelis, Broeckx, Mandigers, Fischer, Storch and Bhatti.)- Published
- 2022
- Full Text
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14. Primary orthostatic tremor and orthostatic tremor-plus in dogs: 60 cases (2003-2020).
- Author
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Liatis T, Gutierrez-Quintana R, Mari L, Czopowicz M, Polidoro D, Bhatti SFM, Cozzi F, Tirrito F, Brocal J, José-López R, Kaczmarska A, Cappello R, Harris G, Alves L, Rusbridge C, and Rossmeisl JH
- Subjects
- Animals, Dizziness veterinary, Dogs, Electromyography veterinary, Retrospective Studies, Dog Diseases drug therapy, Tremor drug therapy, Tremor veterinary
- Abstract
Background: Orthostatic tremor (OT) is a rare movement disorder characterized by high-frequency (>12 Hz) involuntary, rhythmic, sinusoidal movements affecting predominantly the limbs while standing., Objective: To describe the signalment, presenting complaints, phenotype, diagnostic findings, treatment, and outcome of a large sample of dogs with OT., Animals: Sixty dogs diagnosed with OT based on conscious electromyography., Methods: Multicenter retrospective case series study. Dogs were included if they had a conscious electromyography consistent with muscle discharge frequency >12 Hz while standing., Results: Fifty-three cases were diagnosed with primary OT (POT). Giant breed dogs represented most cases (83%; 44/53). Most dogs (79%; 42/53) were younger than 2 years of age at onset of signs, except for Retrievers which were all older than 3.5 years of age. The most common presenting complaints were pelvic limb tremors while standing (85%; 45/53) and difficulty when rising or sitting down (45%; 24/53). Improvement of clinical signs occurred in most dogs (85%; 45/53) treated medically with phenobarbital, primidone, gabapentin, pregabalin or clonazepam, but it was mostly partial rather than complete. Orthostatic tremor-plus was seen in 7 dogs that had concurrent neurological diseases., Conclusions and Clinical Importance: Primary OT is a progressive disease of young, purebred, giant/large-breed dogs, which appears to begin later in life in Retrievers. Primary OT apparently responds partially to medications. Orthostatic tremor-plus exists in dogs and can be concomitant or associated with other neurological diseases., (© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
- Published
- 2022
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15. Phenotypic characterization of paroxysmal dyskinesia in Maltese dogs.
- Author
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Polidoro D, Van Ham L, Santens P, Cornelis I, Charalambous M, Broeckx BJG, and Bhatti SFM
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- Acetazolamide therapeutic use, Animals, Carbonic Anhydrase Inhibitors therapeutic use, Chorea diet therapy, Chorea drug therapy, Diet, Gluten-Free veterinary, Dog Diseases diet therapy, Dog Diseases drug therapy, Dogs, Dyskinesias diagnosis, Dyskinesias diet therapy, Dyskinesias drug therapy, Female, Genetic Predisposition to Disease, Male, Retrospective Studies, Chorea veterinary, Dog Diseases diagnosis, Dyskinesias veterinary
- Abstract
Background: Paroxysmal dyskinesias (PDs) are a group of central nervous system diseases characterized by episodes of abnormal involuntary hyperkinetic movement without altered consciousness that increasingly have been recognized in dogs., Objectives: To present the phenotypical characterization, treatment, and outcome of a PD observed in Maltese dogs., Animals: Client-owned Maltese dogs (n = 19) with presumed diagnosis of PD., Methods: Data were collected retrospectively from medical records (2014-2019), and supporting information was added prospectively by using a questionnaire directed to the owners of the affected dogs., Results: The episodes were characterized mainly by sudden dystonia of ≥1 limbs and generalized body tremors with preserved consciousness. The mean age of clinical onset was 5.4 years. Episode frequency varied widely both among and within individuals. Median episode duration was 4.5 minutes. Most episodes were stress- or exercise-induced. Acetazolamide was administered to 6 dogs, and 4 dogs experienced a decrease in episode frequency. In 7 dogs that received a gluten-free diet, 6 dogs became episode-free. In 4 dogs, the episodes stopped spontaneously and in 2 dogs no medication or specific diet was given and the episodes continued at the same frequency., Conclusions and Clinical Importance: Given the breed predisposition and regional distribution of the disease, additional research should focus on elucidating the underlying genetic cause doing so might advance both our understanding of the pathophysiology and treatment of this disease, not only in dogs, but also in humans. Regardless of the treatment protocol selected, prognosis appears fair to good., (© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
- Published
- 2020
- Full Text
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16. Role of gastric pH in isolation of Helicobacter mustelae from the feces of ferrets.
- Author
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Fox JG, Blanco MC, Yan L, Shames B, Polidoro D, Dewhirst FE, and Paster BJ
- Subjects
- Animals, Biopsy, DNA Probes, DNA Restriction Enzymes analysis, Female, Ferrets, Hydrogen-Ion Concentration, Stomach microbiology, Stomach pathology, Feces microbiology, Gastric Mucosa metabolism, Helicobacter isolation & purification
- Abstract
Background: Helicobacter mustelae colonizes the gastric mucosa of ferrets and causes persistent chronic gastritis., Methods: Hypochlorhydria, as measured by gastric pH probe, was induced by administering oral omeprazole, a proton pump inhibitor of the parietal cell, to adult ferrets in two separate experiments. Feces of ferrets were cultured for H. mustelae before, during, and after omeprazole therapy., Results: H. mustelae was isolated in 23 of 55 (41.8%) sequential fecal samples collected during omeprazole therapy. The same ferrets with acidic gastric pH had H. mustelae isolated in 6 of 62 (9.7%) of the fecal cultures (P < 0.01). A DNA species-specific H. mustelae probe confirmed the presence of the organism in both the stomach and feces of all 5 ferrets. In 4 of 5 ferrets restriction enzyme patterns of the gastric H. mustelae were identical to those of the fecal H. mustelae strains., Conclusions: Hypochlorhydria promotes fecal transmission of a gastric Helicobacter organism. The H. mustelae-colonized ferret provides an ideal model to study the epidemiology and pathogenesis of Helicobacter pylori-induced gastritis.
- Published
- 1993
- Full Text
- View/download PDF
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