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8 results on '"Polico, Rolando"'

4. Efficacy of Different Sequences of Radio- and Chemotherapy in Experimental Models of Human Melanoma

Author

Arienti, Chiara, primary, Zoli, Wainer, additional, Pignatta, Sara, additional, Carloni, Silvia, additional, Paganelli, Giulia, additional, Ulivi, Paola, additional, Romeo, Antonino, additional, Menghi, Enrico, additional, Sarnelli, Anna, additional, Medri, Laura, additional, Polico, Rolando, additional, Silvestrini, Rosella, additional, and Tesei, Anna, additional

Published
2014
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5. In vitro irradiation system for radiobiological experiments

Author

Tesei, Anna, primary, Sarnelli, Anna, additional, Arienti, Chiara, additional, Menghi, Enrico, additional, Medri, Laura, additional, Gabucci, Elisa, additional, Pignatta, Sara, additional, Falconi, Mirella, additional, Silvestrini, Rosella, additional, Zoli, Wainer, additional, D’Errico, Vincenzo, additional, Romeo, Antonino, additional, Parisi, Elisabetta, additional, and Polico, Rolando, additional

Published
2013
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8. GEMOX plus tomotherapy for unresectable locally advanced pancreatic cancer.

Author

Milandri C, Polico R, Garcea D, Passardi A, Gardini A, Romeo A, Scarpi E, Rosetti P, Ridolfi L, La Barba G, Ricci M, and Amadori D

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Combined Modality Therapy, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Female, Humans, Male, Middle Aged, Organoplatinum Compounds administration & dosage, Oxaliplatin, Pancreatic Neoplasms mortality, Pancreatic Neoplasms pathology, Radiotherapy Planning, Computer-Assisted, Tomography, X-Ray Computed, Gemcitabine, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Pancreatic Neoplasms therapy
Abstract

Background/aims: The aim of this prospective phase II study was to evaluate the effect of neoadjuvant GEMOX plus helical tomotherapy on the resectability of locally advanced pancreatic cancer., Methodology: Between November 2004 and July 2008, 33 enrolled patients received gemcitabine (GEM) 1000 mg/m2 on day 1, and oxaliplatin (OX) 100 mg/m2 on day 2, every two weeks for 3-4 cycles. This was followed by radiotherapy (25 Gy, 5 fractions), 15 days after completion of GEMOX. Patients then received a further 3-4 cycles of GEMOX, underwent restaging and were evaluated for surgery. Potentially resectable patients were submitted to surgery, while unresectable responders received further GEMOX and radiotherapy., Results: Toxicity to GEMOX was similar to that reported elsewhere and radiotherapy was also well tolerated. After treatment, one patient achieved a complete response, 14 had a partial response, 11 showed a stable disease, 6 progressed, and one was not evaluable. Eight patients (24%) underwent surgical laparotomy (7 radical pancreatic resections and one explorative laparotomy)., Conclusions: Our study shows the feasibility and potential efficacy of the GEMOX plus helical tomotherapy regimen in unresectable locally advanced pancreatic cancer.

Published
2011

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