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37 results on '"Poletaeva, Inga"'

3. Selection for High Scores of Cognitive Abilities in the Laboratory Mice: Successes and Pitfalls

Author

Poletaeva, Inga I., Perepelkina, Olga V., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Velichkovsky, Boris M., editor, Balaban, Pavel M., editor, and Ushakov, Vadim L., editor

Published
2021
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25. Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele

Author

Spoelstra, Kamiel, Albrecht, Urs, Schmutz, Isabelle, Daan, Moritz, Daan, Berte, Rienks, Froukje, Poletaeva, Inga, Dell'Omo, Giacomo, Vyssotski, Alexei, Lipp, Hans-Peter, Spoelstra, Kamiel, Albrecht, Urs, Schmutz, Isabelle, Daan, Moritz, Daan, Berte, Rienks, Froukje, Poletaeva, Inga, Dell'Omo, Giacomo, Vyssotski, Alexei, and Lipp, Hans-Peter

Abstract

Daily patterns of animal behavior are potentially of vast functional importance. Fitness benefits have been identified in nature by the association between individual timing and survival or by the fate of individuals after experimental deletion of their circadian pacemaker. The recent advances in unraveling the molecular basis of circadian timing enable new approaches to natural selection on timing. The investigators report on the effect and fate of the mutant Per2Brdm1 allele in 4 replicate populations of house mice in a seminatural outside environment over 2 years. This allele is known to compromise circadian organization and entrainment and to cause multiple physiological disturbances. Mice (N = 250) bred from Per2Brdm1 heterozygotes were implanted subcutaneously with transponders and released in approximately Mendelian ratios in four 400 m² pens. An electronic system stored the times of all visits to feeders of each individual. The study first demonstrates that mice are not explicitly nocturnal in this natural environment. Feeding activity was predominantly and sometimes exclusively diurnal and spread nearly equally over day and night under the protective snow cover in winter. The effect of Per2Brdm1 on activity timing is negligible compared to seasonal changes in all genotypes. Second, the Per2Brdm1 allele did not have persistent negative effects on fitness. In the first year, the allele gradually became less frequent by reducing survival. New cohorts captured had the same Per2Brdm1 frequency as the survivors from previous cohorts, consistent with an absence of an effect on reproduction. In the second year, the allele recovered to about its initial frequency (0.54). These changes in selective advantage were primarily due to female mice, as females lived longer and the sex ratio dropped to about 25% males in the population. While it is unknown which selec

Published
2011

28. The p66Shcknockout mice are short lived under natural condition

Author

Giorgio, Marco, primary, Berry, Alessandra, additional, Berniakovich, Ina, additional, Poletaeva, Inga, additional, Trinei, Mirella, additional, Stendardo, Massimo, additional, Hagopian, Kevork, additional, Ramsey, Jon J., additional, Cortopassi, Gino, additional, Migliaccio, Enrica, additional, Nötzli, Sarah, additional, Amrein, Irmgard, additional, Lipp, Hans P., additional, Cirulli, Francesca, additional, and Pelicci, Pier G., additional

Published
2011
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29. P13. Cortexin and combination of nitrite with cortexin decrease swelling and destruction of cerebellar neurons in hemorrhagic stroke

Author

Reutov, Valentin, primary, Krushinsky, Alexey, additional, Kuzenkov, Victor, additional, Sorokina, Elena, additional, Pinelis, Vsevolod, additional, Samosudova, Nina, additional, Filippova, Nataliya, additional, Baider, Larisa, additional, Kuropteva, Zoya, additional, Koshelev, Vladimir, additional, Poletaeva, Inga, additional, Kamensky, Alexander, additional, Esipov, Dmitry, additional, Granstrem, Oleg, additional, Svinov, Mikhail, additional, and Kositzyn, Nikolay, additional

Published
2011
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33. Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: Mutant mice lacking neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility

Author

Vyssotski, Alexei L., primary, Dell'Omo, Giacomo, additional, Poletaeva, Inga I., additional, Vyssotski, Dmitri L., additional, Minichiello, Liliana, additional, Klein, R�diger, additional, Wolfer, David P., additional, and Lipp, Hans-Peter, additional

Published
2002
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36. The p66Shc knocked out mice are short lived under natural condition.

Author

Giorgio, Marco, Berry, Alessandra, Berniakovich, Ina, Poletaeva, Inga, Trinei, Mirella, Stendardo, Massimo, Hagopian, Kevork, Ramsey, Jon J., Cortopassi, Gino, Migliaccio, Enrica, Nötzli, Sarah, Amrein, Irmgard, Lipp, Hans P., Cirulli, Francesca, and Pelicci, Pier G.

Subjects
AGE factors in disease, BODY temperature regulation, ENERGY metabolism, ECOLOGICAL niche, COMPETITION (Biology), REPRODUCTION, LABORATORY mice
Abstract

Summary Deletion of the p66Shc gene results in lean and healthy mice, retards aging, and protects from aging-associated diseases, raising the question of why p66Shc has been selected, and what is its physiological role. We have investigated survival and reproduction of p66Shc−/− mice in a population living in a large outdoor enclosure for a year, subjected to food competition and exposed to winter temperatures. Under these conditions, deletion of p66Shc was strongly counterselected. Laboratory studies revealed that p66Shc−/− mice have defects in fat accumulation, thermoregulation, and reproduction, suggesting that p66Shc has been evolutionarily selected because of its role in energy metabolism. These findings imply that the health impact of targeting aging genes might depend on the specific energetic niche and caution should be exercised against premature conclusions regarding gene functions that have only been observed in protected laboratory conditions. [ABSTRACT FROM AUTHOR]

Published
2012
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37. Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele

Author

Spoelstra, Kamiel, Albrecht, Urs, Schmutz, Isabelle, Daan, Moritz, Daan, Berte, Rienks, Froukje, Poletaeva, Inga, Dell'Omo, Giacomo, Vyssotski, Alexei, Lipp, Hans-Peter, Spoelstra, Kamiel, Albrecht, Urs, Schmutz, Isabelle, Daan, Moritz, Daan, Berte, Rienks, Froukje, Poletaeva, Inga, Dell'Omo, Giacomo, Vyssotski, Alexei, and Lipp, Hans-Peter

Abstract

Daily patterns of animal behavior are potentially of vast functional importance. Fitness benefits have been identified in nature by the association between individual timing and survival or by the fate of individuals after experimental deletion of their circadian pacemaker. The recent advances in unraveling the molecular basis of circadian timing enable new approaches to natural selection on timing. The investigators report on the effect and fate of the mutant Per2Brdm1 allele in 4 replicate populations of house mice in a seminatural outside environment over 2 years. This allele is known to compromise circadian organization and entrainment and to cause multiple physiological disturbances. Mice (N = 250) bred from Per2Brdm1 heterozygotes were implanted subcutaneously with transponders and released in approximately Mendelian ratios in four 400 m² pens. An electronic system stored the times of all visits to feeders of each individual. The study first demonstrates that mice are not explicitly nocturnal in this natural environment. Feeding activity was predominantly and sometimes exclusively diurnal and spread nearly equally over day and night under the protective snow cover in winter. The effect of Per2Brdm1 on activity timing is negligible compared to seasonal changes in all genotypes. Second, the Per2Brdm1 allele did not have persistent negative effects on fitness. In the first year, the allele gradually became less frequent by reducing survival. New cohorts captured had the same Per2Brdm1 frequency as the survivors from previous cohorts, consistent with an absence of an effect on reproduction. In the second year, the allele recovered to about its initial frequency (0.54). These changes in selective advantage were primarily due to female mice, as females lived longer and the sex ratio dropped to about 25% males in the population. While it is unknown which selec

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