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1. Estimating pediatric general anesthesia exposure: Quantifying duration and risk

Author

Bartels, Devan Darby, McCann, Mary Ellen, Davidson, Andrew J, Polaner, David M, Whitlock, Elizabeth L, and Bateman, Brian T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Clinical Research, Patient Safety, Anesthesia, General, Child, Child, Preschool, Cohort Studies, Female, Humans, Infant, Male, Pediatrics, Retrospective Studies, Risk, Time Factors, adolescent, child, general anesthesia, infant, neonate, neurodevelopment, Paediatrics and Reproductive Medicine, Anesthesiology, Clinical sciences, Paediatrics
Abstract

INTRODUCTION:Understanding the duration of pediatric general anesthesia exposure in contemporary practice is important for identifying groups at risk for long general anesthesia exposures and designing trials examining associations between general anesthesia exposure and neurodevelopmental outcomes. METHODS:We performed a retrospective cohort analysis to estimate pediatric general anesthesia exposure duration during 2010-2015 using the National Anesthesia Clinical Outcomes Registry. RESULTS:A total of 1 548 021 pediatric general anesthetics were included. Median general anesthesia duration was 57 minutes (IQR: 28-86) with 90th percentile 145 minutes. Children aged 3 hours. High ASA physical status and care at a university hospital were associated with longer exposure times. CONCLUSION:While the vast majority (94%) of children undergoing general anesthesia are exposed for

Published
2018

3. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

Author

Davidson, Andrew J, Frawley, Geoff, Hardy, Pollyanna, Arnup, Sarah, Grobler, Anneke, Lee, Katherine, Hunt, Rod W, Stargatt, Robyn, Sheppard, Suzette J, Ormond, Gillian D, Hartmann, Penelope L, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, von Ungern-Sternberg, Britta, Wilton, Niall C, Knottenbelt, Graham, Withington, Davinia, Furue, Koto, Gagnon, Hélène, Disma, Nicola, Mameli, Leila, Giribaldi, Gaia, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Izzo, Francesca, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, de Graaff, Jurgen C, van der Werff, Desiree BM, van Gool, Jose TDG, van Loon, Kim, Kalkman, Cor J, van Baar, Anneloes L, Absalom, Anthony R, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Bell, Graham, Dorris, Liam, Morton, Neil S, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, McCann, Mary Ellen, Berde, Charles, Soriano, Sulpicio, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Bellinger, David, Marmor, Jacki, Lynn, Anne, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Mueller, Martin, Haret, Denisa, Szmuk, Peter, Steiner, Jeffrey, Kravitz, Brian, Farrow-Gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, Williams, Robert, Hunt, Rodney W, Bellinger, David C, von Ungern Sternberg, Britta S, Wilton, Niall, Polaner, David M, and Morton, Neil

Published
2019
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8. Contributors

Author

Adams, Trevor L., primary, Adler, Adam C., additional, Ames, Warwick A., additional, Anderson, Brian J., additional, Andropoulos, Dean B., additional, Anixter, Martin B., additional, Arnold, Philip, additional, Baker, Robert, additional, Bender, M.A., additional, Berde, Charles B., additional, Berenstain, Laura K., additional, Blasiole, Brian, additional, Bösenberg, Adrian T., additional, Brown, Karen A., additional, Brusseau, Roland, additional, Cain, James Gordon, additional, Chidambaran, Vidya, additional, Cladis, Franklyn P., additional, Claure, Rebecca E., additional, Cooper, Jeffrey B., additional, Coté, Charles J., additional, Cravero, Joseph P., additional, Crean, Peter M., additional, Davidson, Andrew J., additional, Davis, Peter J., additional, DiNardo, James A., additional, Eisses, Michael J., additional, Fiadjoe, John E., additional, Firth, Paul G., additional, Foreman, John W., additional, Forshaw, Natalie, additional, Fortier, Michelle A., additional, Gangadharan, Sandeep, additional, Gertler, Ralph, additional, Ghazal, Elizabeth A., additional, Goldschneider, Kenneth, additional, Gottlieb, Erin A., additional, Grabowski, Eric F., additional, Grogan, Kelly L., additional, Gulur, Padma, additional, Haberkern, Charles M., additional, Hammer, Gregory B., additional, Hannallah, Raafat S., additional, Hansen, Tom G., additional, Havidich, Jeana E., additional, Henneberg, Steen W., additional, Houghton, James, additional, Jaichenco, Andre L., additional, Kain, Zeev N., additional, Kaplan, Richard F., additional, Karmakar, Manoj K., additional, Kinane, T. Bernard, additional, Krane, Elliot J., additional, Kwok, Wing H., additional, Rolo, Vasco Laginha, additional, Lam, Jennifer E., additional, Landrigan-Ossar, Mary, additional, Latham, Gregory J., additional, Lerman, Jerrold, additional, Lima, Luciana Cavalcanti, additional, Litman, Ronald S., additional, Loepke, Andreas W., additional, Mai, Christine L., additional, Marciniak, Bruno, additional, Martyn, J.A. Jeevendra, additional, Mason, Linda J., additional, Mayes, Linda C., additional, McClain, Craig D., additional, McEwan, Angus, additional, McManus, Michael L., additional, Mendoza, Julianne, additional, Mihm, Frederick G., additional, Miller-Hance, Wanda C., additional, Nawathe, Pooja, additional, Parness, Jerome, additional, Polaner, David M., additional, Rawlinson, Ellen, additional, Rhodes, Erinn T., additional, Ross, Faith J., additional, Ross, Patrick A., additional, Rowe, Echo, additional, Sadhasivam, Senthilkumar, additional, Schleien, Charles L., additional, Schure, Annette Y., additional, Serber, Julia F., additional, Shank, Erik S., additional, Soriano, Sulpicio G., additional, Spaeth, James P., additional, Squires, James E., additional, Squires, Robert H., additional, Stowell, Christopher P., additional, Stricker, Paul A., additional, Suresh, Santhanam, additional, Szabova, Alexandra, additional, Szyld, Demian, additional, Taenzer, Andreas H., additional, Tirupathi, Sandya, additional, Tobin, Joseph R., additional, Vadi, Marissa G., additional, Verghese, Susan T., additional, Waisel, David B., additional, Wald, Samuel H., additional, Walker, Benjamin J., additional, Weaver, R. Grey, additional, Wesson, David E., additional, Wigfall, Delbert R., additional, Wilton, Niall C., additional, Wolfsdorf, Joseph I., additional, and Young, David A., additional

Published
2019
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10. Acute Pain

Author

Walker, Benjamin J., primary, Polaner, David M., additional, and Berde, Charles B., additional

Published
2019
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14. Hyperammonemia is associated with reduced objective anesthetic requirements in children: A retrospective case–control study.

Author

O'Reilly‐Shah, Vikas N., Van Cleve, Wil, Walters, Andrew, Hunyady, Agnes I., Morgan, Philip G., Li, Li, and Polaner, David M.

Subjects
CHILD patients, HYPERAMMONEMIA, ANESTHETICS, CASE-control method
Abstract

A retrospective case-control study published in the journal Pediatric Anesthesia examined the impact of hyperammonemia, or elevated blood ammonia levels, on anesthetic requirements in children. The study analyzed processed electroencephalogram (EEG) data as a measure of anesthetic depth in hyperammonemic pediatric patients compared to healthy controls. The results showed that children with hyperammonemia exhibited greater anesthetic depth at lower anesthetic concentrations compared to age-matched controls without hyperammonemia. The study suggests that the presence of hyperammonemia is associated with enhanced sensitivity to anesthetics in pediatric patients. However, further research is needed to confirm these findings and understand the underlying mechanisms. [Extracted from the article]

Published
2024
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18. List of Contributors

Author

Abbasi, Rania K., Adams, Trevor L., Adler, Adam C., Ames, Warwick A., Anderson, Brian J., Andropoulos, Dean B., Anninger, William, Arnold, Philip, Awad, Motaz, Bailey, Philip D., Jr., Bender, M.A., Berenstain, Laura K., Bösenberg, Adrian T., Braunold, Daniel, Sinai, Yitzhak Brzezinski, Burgart, Alyssa M., Butler, Carolyn G., Carr, Michele M., Carter, Harmony F., Lima, Luciana Cavalcanti, Chidambaran, Vidya, Chua, Annabelle N., Cooper, Jeffrey B., Coté, Charles J., Cravero, Joseph P., Damian, Daniela, Davidson, Andrew J., DiNardo, James A., Docquier, Marie-Agnès, Earley, Timothy M., Eisses, Michael J., Ferschl, Marla B., Fiadjoe, John E., Firth, Paul G., Flannery, Kaitlin M., Gertler, Ralph, Ghazal, Elizabeth A., Goldschneider, Kenneth, Gottlieb, Erin A., Grabowski, Eric F., Hamilton, A. Rebecca L., Hammer, Gregory B., Hansen, Tom G., Havidich, Jeana E., Houghton, James, Hunter, Samuel A., Hylton, Jared R.E., Jaichenco, Andre L., Sr., Jones, Cathie T., Kanmanthreddy, Siri, Karmakar, Manoj Kumar, Kinane, T. Bernard, Kumar, Reeti, Rolo, Vasco Laginha, Lam, Jennifer E., Landrigan-Ossar, Mary, Latham, Gregory J., Lehavi, Amit, Lerman, Jerrold, Loepke, Andreas W., Mai, Christine L., Mandell, Iris, Martin, Lizabeth D., Martyn, J.A. Jeevendra, Masip, Nuria, Mason, Linda J., McClain, Craig D., McEwan, Angus, McManus, Michael L., Mendoza, Julianne, Miller-Hance, Wanda C., Murto, Kimmo, Nassogne, Marie-Cécile, Nawathe, Pooja, Nelson, Olivia, Nichols, John H., Ojo, Bukola, Olbrecht, Vanessa A., Packiasabapathy, Senthil, Pan, Stephanie J., Polaner, David M., Quinlan, Casey A., Rawlinson, Ellen, Rhodes, Erinn T., Rollins, Mark D., Rowe, Echo, Ross, Faith J., Sadhasivam, Senthil, Schleien, Charles L., Schure, Annette Y., Sequera-Ramos, Luis, Sheffy, Nadav, Simhi, Eliahu, Skowno, Justin J., Sloan, Steven R., Soriano, Sulpicio G., Spaeth, James P., Squires, James E., Srivatsa, Abhinash, Stein, Mary Lyn, Stocki, Daniel, Stricker, Paul A., Sunder, Rani, Suresh, Santhanam, Szabova, Alexandra, Taenzer, Andreas H., Vetterly, Carol, Veyckemans, Francis, Waisel, David B., Walker, Benjamin, Wang, Jue Teresa, Welch, John C., Wilton, Niall C., Wolfsdorf, Joseph I., and Yip, Peggy

Published
2025
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19. Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network

Author

Walker, Benjamin J., Long, Justin B., Sathyamoorthy, Madhankumar, Birstler, Jennifer, Wolf, Christine, Bosenberg, Adrian T., Flack, Sean H., Krane, Elliot J., Sethna, Navil F., Suresh, Santhanam, Taenzer, Andreas H., Polaner, David M., Martin, Lynn, Anderson, Corrie, Sunder, Rani, Adams, Trevor, Martin, Lizabeth, Pankovich, Martha, Sawardekar, Amod, Birmingham, Patrick, Marcelino, Ryan, Ramarmurthi, R.J., Szmuk, Peter, Ungar, Galit Kastner, Lozano, Sara, Boretsky, Karen, Jain, Ranu, Matuszczak, Maria, Petersen, Timothy R., Dillow, Jennifer, Power, Robert, Nguyen, Kim, Lee, Benjamin H., Chan, Lisa, Pineda, Jorge, Hutchins, Jacob, Mendoza, Kimberly, Spisak, Kristen, Shah, Aali, DelPizzo, Kathryn, Dong, Naomi, Yalamanchili, Vidya, Venable, Claudia, Williams, Cassandra Armstead, Chaudahari, Reena, Ohkawa, Susumu, Usljebrka, Helga, Bhalla, Tarun, Vanzillotta, Pedro Paulo, Apiliogullari, Seza, Franklin, Andrew D., Ando, Akiko, Pestieau, Sophie R., Wright, Caroline, Rosenbloom, Julia, and Anderson, Tony

Published
2018
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20. Contributors

Author

Bailey, Ann G., primary, Balzer, Jeffrey R., additional, Baum, Victor C., additional, Beebe, David S., additional, Beers, Sue R., additional, Belani, Kumar G., additional, Bissonette, Bruno, additional, Blasiole, Brian, additional, Bosenberg, Adrian T., additional, Brandom, Barbara W., additional, Brett, Claire M., additional, Cain, James G., additional, Chalifoux, Thomas M., additional, Cladis, Franklyn P., additional, Cohen, David E., additional, Cohen, Ira T., additional, Cravero, Joseph P., additional, Dalesio, Nicholas M., additional, Davidson, Andrew, additional, Davis, Jessica, additional, Davis, Peter J., additional, de Souza, Duncan G., additional, Deutsch, Nina, additional, Diaz, Laura K., additional, DiNardo, James A., additional, Ehrlich, Peter F., additional, Ellis, Demetrius, additional, Fehr, James J., additional, Feldman, Jeffrey M., additional, Felmet, Kathryn, additional, Finder, Jonathan D., additional, Flack, Sean, additional, Flick, Randall P., additional, Fortier, Michelle A., additional, Frawley, Geoff, additional, Gadepalli, Samir K., additional, Galinkin, Jeffrey L., additional, Glass, Nancy, additional, Goodwin, Salvatore R., additional, Gregory, George A., additional, Grunwaldt, Lorelei, additional, Gulur, Padma, additional, Guzzetta, Nina A., additional, Haile, Dawit T., additional, Hall-Burton, Denise M., additional, Hammer, Gregory B., additional, Hamrick, Jennifer L., additional, Hamrick, Justin T., additional, Hayward, Daniel M., additional, Heitmiller, Eugenie S., additional, Herlich, Andrew, additional, Holzman, Robert S., additional, Hsieh, Vincent C., additional, Hunt, Elizabeth A., additional, Ibinson, James W., additional, Justice, Lori T., additional, Kain, Zeev N., additional, Kharasch, Evan, additional, Koka, Rahul, additional, Kost-Byerly, Sabine, additional, Krane, Elliot J., additional, Kussman, Barry D., additional, Lang, Robert Scott, additional, Lauro, Helen Victoria, additional, Lee, Jennifer K., additional, Losee, Joseph, additional, Luginbuehl, Igor, additional, Mahmoud, Mohamed, additional, Martin, Brian, additional, Mason, Keira P., additional, Mauermann, William J., additional, Maxwell, Lynne G., additional, McGowan, Francis X., additional, Miller, Bruce E., additional, Monitto, Constance L., additional, Morgan, Philip G., additional, Moritz, Michael L., additional, Motoyama, Etsuro K., additional, Nemergut, Michael E., additional, Niezgoda, Julie, additional, Ohliger, Shelley, additional, Pian, Phillip M.T., additional, Polaner, David M., additional, Politis, George D., additional, Powell, Andrew J., additional, Reynolds, Paul, additional, Ricketts, Karene, additional, Ro, Richard S., additional, Rockoff, Mark A., additional, Romanelli, Thomas, additional, Samol, Nancy Bard, additional, Samuels, Paul J., additional, Scattoloni, Joseph A., additional, McElrath Schwartz, Jamie, additional, Schwengel, Deborah A., additional, Scott, Victor L., additional, Shaffner, Donald H., additional, Shukla, Avinash C., additional, Simpao, Allan F., additional, Sivak, Erica L., additional, Sjoblom, Matthew D., additional, Soltys, Kyle, additional, Soriano, Sulpicio G., additional, Stickles, Eric T., additional, Thomas, Jennifer M., additional, Tofovic, Stevan P., additional, Tran, Kha M., additional, Trivedi, Premal M., additional, Valley, Robert D., additional, Vavilala, Monica S., additional, Vecchione, Lisa, additional, Vogt, Keith M., additional, Wahl, Jeffrey R., additional, Wahl, Kerri M., additional, Weintraub, Ari Y., additional, Welch, Timothy P., additional, Williams, Robert K., additional, Wittkugel, Eric P., additional, Woelfel, Susan, additional, Yaster, Myron, additional, Yuki, Koichi, additional, Zgleszewski, Steven, additional, Zitelli, Basil J., additional, and Zuckerberg, Aaron L., additional

Published
2017
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24. A comparison of pediatric liver transplant anesthesia practices with new organ procurement and transplant network pediatric policy requirements: A report from the society for the advancement of transplant anesthesia and the society for pediatric anesthesia

Author

Moguilevitch, Marina, primary, Polaner, David M., additional, Mann, Glenn, additional, Mauner, Aaron, additional, Beagley, Britni, additional, Hendrickse, Adrian, additional, Stoll, William D, additional, DeMarchi, Lorenzo, additional, Damian, Daniela, additional, Sridhar, Srikanth, additional, Costandi, Andrew, additional, Tran, Lieu, additional, Jorge, Lydia M, additional, and Mandell, M. Susan, additional

Published
2022
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29. Contributors

Author

Bailey, Ann G., primary, Bansal, Vipin, additional, Barinholtz, David, additional, Baum, Victor C., additional, Beebe, David S., additional, Belani, Kumar G., additional, Berkowitz, Richard, additional, Bissonnette, Bruno, additional, Bosenberg, Adrian, additional, Brandom, Barbara W., additional, Brett, Claire, additional, Bryskin, Robert B., additional, Callahan, Patrick, additional, Cladis, Franklyn P., additional, Cohen, David E., additional, Cohen, Ira Todd, additional, Davidson, Andrew, additional, Davis, Jessica, additional, Davis, Peter J., additional, de Souza, Duncan, additional, Deutsch, Nina, additional, DiNardo, James A., additional, Ehrlich, Peter, additional, Ellis, Demetrius, additional, Feldman, Jeffrey M., additional, Felmet, Kathryn, additional, Fiadjoe, John E., additional, Finder, Jonathan D., additional, Flick, Randall P., additional, Fortier, Michelle, additional, Goodwin, Salvatore R., additional, Gregory, George A., additional, Grunwaldt, Lorelei, additional, Haile, Dawit T., additional, Hall, Steven, additional, Hammer, Gregory, additional, Hauser, Michael W., additional, Heitmiller, Eugenie S., additional, Herlich, Andrew, additional, Holzman, Robert S., additional, Hunt, Elizabeth A., additional, Jimenez, Nathalia, additional, Justice, Lori T., additional, Kain, Zeev N., additional, Kharasch, Evan, additional, Kost-Byerly, Sabine, additional, Krane, Elliot J., additional, Kussman, Barry D., additional, Landsman, Ira S., additional, Litman, Ronald S., additional, Losee, Joseph, additional, Luginbuehl, Igor, additional, Lynn, Anne M., additional, Mancuso, Thomas J., additional, Martin, Brian P., additional, Mason, Keira, additional, Mauermann, William J., additional, Maxwell, Lynne G., additional, McDaniel, George M., additional, McGowan, Francis X., additional, Monitto, Constance L., additional, Morgan, Philip G., additional, Motoyama, Etsuro K., additional, Niezgoda, Julie, additional, Polaner, David M., additional, Reynolds, Paul, additional, Rockoff, Mark A., additional, Romanelli, Thomas, additional, Ross, Allison Kinder, additional, Scattoloni, Joseph A., additional, Schwartz, Jamie McElrath, additional, Sclabassi, Robert J., additional, Scott, Victor L., additional, Shaffner, Donald H., additional, Shukla, Avinash C., additional, Smith, Robert M., additional, Soltys, Kyle, additional, Soriano, Sulpicio G., additional, Struyk, Brian P., additional, Sullivan, Kevin J., additional, Thomas, Jennifer, additional, Tofovic, Stevan P., additional, Tran, Kha, additional, Tyler, Donald C., additional, Valley, Robert D., additional, Vavilala, Monica S., additional, Vecchione, Lisa, additional, Wahl, Kerri M., additional, Werkhaven, Jay A., additional, Woelfel, Susan, additional, Yaster, Myron, additional, Zuckerberg, Aaron L., additional, Alper, Cuneyt M., additional, Borland, Lawrence M., additional, Cain, James G., additional, Devine, William A., additional, Dohar, Joseph E., additional, Grande, Christopher M., additional, Kane, Timothy D., additional, Lanford, Lizabeth M., additional, Mazariegos, George V., additional, Potoka, Douglas A., additional, Rothfield, Kenneth P., additional, and Yellon, Robert F., additional

Published
2011
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31. Contributors

Author

Anderson, Brian, primary, Andropoulos, Dean B., additional, Anixter, Miriam, additional, Bender, M.A., additional, Berde, Charles, additional, Berry, Frederic A., additional, Bissonnette, Bruno, additional, Blum, Richard H., additional, Bosenberg, Adrian T., additional, Brown, Karen A., additional, Brusseau, Roland, additional, Cain, James, additional, Chang, Anthony, additional, Chi, Carolyn I., additional, Cladis, Franklyn, additional, Cot é, Charles J., additional, Cravero, Joseph P., additional, Crawford, Mark W., additional, Crean, Peter, additional, Davidson, Andrew J., additional, Davis, Peter J., additional, DeSoto, Hernando, additional, Diaz, Laura K., additional, Eisses, Michael J., additional, Engelhardt, Thomas, additional, Everett, Lucinda L., additional, Firth, Paul G., additional, Foreman, John, additional, Fuzaylov, Gennadiy, additional, Gertler, Ralph, additional, Ghazal, Elizabeth A., additional, Goldschneider, Kenneth, additional, Goudsouzian, Nishan, additional, Grabowski, Eric F., additional, Haberkern, Charles M., additional, Hammer, Gregory B., additional, Hannallah, Raafat S., additional, Haver, Kenan E., additional, Hicks, Elaine, additional, Insoft, Robert M., additional, Jaichenco, Andre, additional, Kain, Zeev N., additional, Kaplan, Richard F., additional, Karmakar, Manoj K., additional, Koka, Babu V., additional, Krane, Elliot J., additional, Kurth, C. Dean, additional, Kwok, Wing H., additional, Lane, Geoffrey K., additional, Lerman, Jerrold, additional, Lichtenstein, Steven, additional, Lönnqvist, Per-Arne, additional, Luginbuehl, Igor, additional, Lugo, Ralph A., additional, MacLaren, Jill, additional, Malviya, Shobha, additional, Martyn, J.A. Jeevendra, additional, Mason, Keira P., additional, Mason, Linda J., additional, Mayes, Linda C., additional, McClain, Craig D., additional, McEwan, Angus, additional, McGowan, Francis X., additional, McManus, Michael L., additional, Miller-Hance, Wanda C., additional, Morris, Marilyn C., additional, Morton, Neil S., additional, Murat, Isabelle, additional, Myers, Laura B., additional, Neely, E. Kirk, additional, Parness, Jerome, additional, Polaner, David M., additional, Rhodes, Erinn T., additional, Rivera, Marcus R., additional, Roberts, Jesse D., additional, Rockoff, Mark A., additional, Romanelli, Thomas M., additional, Ross, Allison Kinder, additional, Schleien, Charles L., additional, Shank, Erik S., additional, Sheridan, Robert L., additional, Shukla, Avinash C., additional, Skinner, Adam, additional, Slesnick, Timothy C., additional, Soriano, Sulpicio G., additional, Spaeth, James P., additional, Squires, Robert H., additional, Steven, James M., additional, Stough, Robert C., additional, Stowell, Christopher P., additional, Suresh, Santhanam, additional, Szabova, Alexandra, additional, Taenzer, Andreas, additional, Tepas, Joseph J., additional, Tobin, Joseph R., additional, Todres, I. David, additional, Truog, Robert D., additional, Verghese, Susan T., additional, Waisel, David B., additional, Wald, Samuel H., additional, Ward, Robert M., additional, Weaver, R. Grey, additional, Webel, Nicole E., additional, West, Rebecca W., additional, Wheeler, Melissa, additional, Wigfall, Delbert R., additional, Wilton, Niall, additional, Wolf, Andrew, additional, Wolfsdorf, Joseph I., additional, and Yaster, Myron, additional

Published
2009
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33. Acute Pain

Author

Malviya, Shobha, primary, Polaner, David M., additional, and Berde, Charles, additional

Published
2009
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40. Contributors

Author

Bailey, Ann G., primary, Baker, Matthew B., additional, Baum, Victor C., additional, Beebe, David S., additional, Belani, Kumar G., additional, Berkowitz, Richard A., additional, Bikhazi, George B., additional, Bissonnette, Bruno, additional, Brandom, Barbara W., additional, Brett, Claire M., additional, Cladis, Franklyn P., additional, Cohen, David E., additional, Cohen, Ira T., additional, Cook, D. Ryan, additional, Davis, Peter J., additional, Deshpande, Jayant K., additional, Domino, Karen B., additional, Easley, R. Blaine, additional, Ellis, Demetrius, additional, Fine, Gavin F., additional, Fischer, Carl G., additional, Galinkin, Jeffrey L., additional, Goodwin, Salvatore R., additional, Greeley, William J., additional, Gronert, Brian J., additional, Hall, Steven C., additional, Hammer, Gregory B., additional, Hauser, Michael Winn, additional, Herlich, Andrew, additional, Holzman, Robert S., additional, Ing, Richard J., additional, Innocent, Jodi, additional, Kain, Zeev N., additional, Kelly, Kevin J., additional, Kern, Frank H., additional, Krane, Elliot J., additional, Landsman, Ira S., additional, Lerman, Jerrold, additional, Litman, Ronald S., additional, Luginbuehl, Igor, additional, Malviya, Shobha, additional, Mancuso, Thomas J., additional, Mason, Keira P., additional, Maxwell, Lynne, additional, McCall, John E., additional, McGowan, Francis X., additional, Morgan, Philip G., additional, Motoyama, Etsuro K., additional, Philip, Bridget M., additional, Polaner, David M., additional, Reynolds, Paul I., additional, Robertson, Kerri M., additional, Rockoff, Mark A., additional, Ross, Allison Kinder, additional, Rusy, Lynn M., additional, Salem, M. Ramez, additional, Schleien, Charles L., additional, Schwarz, Uwe, additional, Sclabassi, Robert J., additional, Scott, Victor L., additional, Shaffner, Donald H., additional, Shukla, Avinash C., additional, Smith, Robert M., additional, Soldes, Oliver S., additional, Strafford, Maureen A., additional, Tofovic, Stevan P., additional, Valley, Robert D., additional, Werkhaven, Jay A., additional, Vogeley, Eva, additional, Weisman, Steven J., additional, Yaster, Myron, additional, Yeh, Kelly K., additional, Zgleszewski, Steven E., additional, and Zuckerberg, Aaron L., additional

Published
2006
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41. Respiratory physiology at high altitude and considerations for pediatric patients.

Author

Bebic, Zvonimir, Brooks Peterson, Melissa, Polaner, David M., and von Ungern‐Sternberg, Britta

Subjects
CHILD patients, ALTITUDES, CEREBRAL circulation, MOUNTAIN sickness, CONGENITAL heart disease
Abstract

Over 150 million people, including many children, live at high altitude (>2500 m) with the majority residing in Asia and South America. With increases in elevation, the partial pressure of oxygen (pO2) is reduced, resulting in a hypobaric hypoxic environment. Fortunately, humans have evolved adaptive processes which serve to acclimate the body to such conditions. These mechanisms, occurring along a specific time course, result in tachypnea, tachycardia, diuresis, and hematopoiesis, and a shift in the oxygen dissociation curve favoring an increased affinity for oxygen. These, along with other physiological effects, including increased pulmonary vascular resistance, alterations in cerebral blood flow, and changes in sensitivity to opioids, must be considered when administering anesthesia at high altitudes. Susceptible individuals or those who ascend too quickly may outpace the body's ability to acclimate resulting in one or more forms of high‐altitude sickness ranging from the milder acute mountain sickness to the more serious conditions of high‐altitude pulmonary edema and cerebral edema, either of which can be life‐threatening if not promptly recognized and treated. Since the adaptive mechanisms for acclimatization greatly affect the cardiopulmonary systems, patients with underlying health issues such as sleep apnea, congenital heart disease, and asthma may have susceptibilities and warrant special consideration. Clinicians should have an understanding of the physiologic adaptations, anesthetic considerations, and special concerns in these populations in order to offer the best care possible. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

Author

Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, Williams, Robert, Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, and Williams, Robert

Abstract

Background In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have found no evidence for an association. We aimed to establish whether general anaesthesia in early infancy affects neurodevelopmental outcomes. Methods In this international, assessor-masked, equivalence, randomised, controlled trial conducted at 28 hospitals in Australia, Italy, the USA, the UK, Canada, the Netherlands, and New Zealand, we recruited infants of less than 60 weeks' postmenstrual age who were born at more than 26 weeks' gestation and were undergoing inguinal herniorrhaphy, without previous exposure to general anaesthesia or risk factors for neurological injury. Patients were randomly assigned (1:1) by use of a web-based randomisation service to receive either awake-regional anaesthetic or sevoflurane-based general anaesthetic. Anaesthetists were aware of group allocation, but individuals administering the neurodevelopmental assessments were not. Parents were informed of their infants group allocation upon request, but were told to mask this information from assessors. The primary outcome measure was full-scale intelligence quotient (FSIQ) on the Wechsler Preschool and Primary Scale of Intelligence, third edition (WPPSI-III), at 5 years of age. The primary analysis was done on a per-protocol basis, adjusted for gestational age at birth and country, with multiple imputation used to account for missing data. An intention-to-treat analysis was also done. A difference in means of 5 points was predefined as the clinical equivalence margin. This completed trial is registered with ANZCTR, number ACTRN12606000441516, and ClinicalTrials.gov, number NCT00756600. Findings Between F

Published
2019

44. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, Williams, Robert, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, and Williams, Robert

Published
2019

46. Sedation, Risk, and Safety: Do We Really Have Data at Last?

Author

Polaner, David M., Houck, Constance S., Rockoff, Mark A., Mancuso, Thomas J., Finley, G. Allen, Maxwell, Lynne G., Cravero, Joseph, Kain, Zeev N., Bell, Charlotte, Bosenberg, Adrian, Zwass, Maurice, Valley, Robert, Agarwal, Rita, Savarese, Anne, Rice, Linda Jo, Coté, Charles J., Davidson, Patricia J., Ferrari, Lynne R., and Davis, Peter J.

Published
2001

47. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

Author

McCann, Mary Ellen, primary, de Graaff, Jurgen C, additional, Dorris, Liam, additional, Disma, Nicola, additional, Withington, Davinia, additional, Bell, Graham, additional, Grobler, Anneke, additional, Stargatt, Robyn, additional, Hunt, Rodney W, additional, Sheppard, Suzette J, additional, Marmor, Jacki, additional, Giribaldi, Gaia, additional, Bellinger, David C, additional, Hartmann, Penelope L, additional, Hardy, Pollyanna, additional, Frawley, Geoff, additional, Izzo, Francesca, additional, von Ungern Sternberg, Britta S, additional, Lynn, Anne, additional, Wilton, Niall, additional, Mueller, Martin, additional, Polaner, David M, additional, Absalom, Anthony R, additional, Szmuk, Peter, additional, Morton, Neil, additional, Berde, Charles, additional, Soriano, Sulpicio, additional, Davidson, Andrew J, additional, Arnup, Sarah, additional, Lee, Katherine, additional, Hunt, Rod W, additional, Ormond, Gillian D, additional, Takagi, Michael J, additional, Taylor, Kaitlyn, additional, Malarbi, Stephanie, additional, Doyle, Melissa, additional, Ragg, Philip, additional, Costi, David, additional, von Ungern-Sternberg, Britta, additional, Wilton, Niall C, additional, Knottenbelt, Graham, additional, Furue, Koto, additional, Gagnon, Hélène, additional, Mameli, Leila, additional, Pini Prato, Alessio, additional, Mattioli, Girolamo, additional, Wolfler, Andrea, additional, Bova, Stefania M, additional, Krachmalnicoff, Arianna, additional, Guuva, Claudia, additional, van der Werff, Desiree BM, additional, van Gool, Jose TDG, additional, van Loon, Kim, additional, Kalkman, Cor J, additional, van Baar, Anneloes L, additional, Hoekstra, Frouckje M, additional, Volkers, Martin, additional, Oostra, Martine, additional, Morton, Neil S, additional, Pownall, Jaycee, additional, Waldman, Jack, additional, Hind, Ruth, additional, Symonds, Joseph D, additional, Bagshaw, Oliver, additional, McCann, Mary Ellen, additional, Sethna, Navil, additional, Kovatsis, Pete, additional, Cravero, Joseph, additional, Bellinger, David, additional, Ivanova, Iskra, additional, Hunyady, Agnes, additional, Verma, Shilpa, additional, Polaner, David, additional, Thomas, Joss, additional, Haret, Denisa, additional, Steiner, Jeffrey, additional, Kravitz, Brian, additional, Farrow-Gillespie, Alan, additional, Suresh, Santhanam, additional, Hays, Stephen, additional, Taenzer, Andreas, additional, Maxwell, Lynne, additional, and Williams, Robert, additional

Published
2019
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