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Your search keyword '"Pokorny, Matous"' showing total 9 results
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9 results on '"Pokorny, Matous"'

1. Modular Hardware Design and Realization for Vital Signs Monitoring

Author

Havlík, Jan, Lhotská, Lenka, Parák, Jakub, Pokorný, Matouš, Dvořak, Jan, Horčík, Zdeněk, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Bravo, José, editor, Hervás, Ramón, editor, and Rodríguez, Marcela, editor

Published
2012
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2. Adaptive Model of Cardiovascular System: Realization and Signal Database

Author

Havlík, Jan, Ložek, Miroslav, Pokorný, Matouš, Parák, Jakub, Huňka, Petr, Lhotská, Lenka, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Bursa, Miroslav, editor, Khuri, Sami, editor, and Renda, M. Elena, editor

Published
2013
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5. A Modular System for Rapid Development of Telemedical Devices

Author

Jan Havlík, Lhotska, Lenka, Parak, Jakub, Dvorak, Jan, Horcik, Zdenek, and Pokorny, Matous

Subjects
plethysmography, assistive technologies, electrocardiography, heart rate, telemonitoring, telemedicine
Abstract

Remote patient monitoring is gradually attracting more attention as the population in developed countries ages, and as chronic diseases appear more frequently in the population. Miniaturization in electronics and mobile technologies has led to rapid development of various wearable systems for remote monitoring of vital signs, supervision systems in home care, assistive technologies and similar systems. There is a significant demand for developing the necessary devices very rapidly, especially for shortening the way from an idea to a first function sample. This paper presents a solution for rapidly developing devices for telemedical applications, remote monitoring and assistive technologies. The approach used here is to design and realize a modular system consisting of input modules for signal acquisition, a control unit for signal pre-processing, handshaking of data communication, controlling the system and providing the user interface and communication modules for data transmission to a superordinate system. A description of specific applications developed on the basis of the system is also presented in the paper.

Published
2013

8. Longitudinal study revealing motor, cognitive and behavioral decline in a transgenic minipig model of Huntington's disease

Author

Baxa, Monika, Levinska, Bozena, Skrivankova, Monika, Pokorny, Matous, Juhasova, Jana, Klima, Jiri, Klempir, Jiri, Motlı́k, Jan, Juhas, Stefan, and Ellederova, Zdenka

Abstract

Huntington's disease (HD) is an inherited devastating neurodegenerative disease with no known cure to date. Several therapeutic treatments for HD are in development, but their safety, tolerability and efficacy need to be tested before translation to bedside. The monogenetic nature of this disorder has enabled the generation of transgenic animal models carrying a mutant huntingtin (mHTT) gene causing HD. A large animal model reflecting disease progression in humans would be beneficial for testing the potential therapeutic approaches. Progression of the motor, cognitive and behavioral phenotype was monitored in transgenic Huntington's disease minipigs (TgHD) expressing the N-terminal part of human mHTT. New tests were established to investigate physical activity by telemetry, and to explore the stress-induced behavioral and cognitive changes in minipigs. The longitudinal study revealed significant differences between 6- to 8-year-old TgHD animals and their wild-type (WT) controls in a majority of the tests. The telemetric study showed increased physical activity of 4.6- to 6.5-year-old TgHD boars compared to their WT counterparts during the lunch period as well as in the afternoon. Our phenotypic study indicates progression in adult TgHD minipigs and therefore this model could be suitable for longstanding preclinical studies of HD. This article has an associated First Person interview with the first author of the paper.

Published
2020
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9. Longitudinal study revealing motor, cognitive and behavioral decline in a transgenic minipig model of Huntington's disease.

Author

Baxa M, Levinska B, Skrivankova M, Pokorny M, Juhasova J, Klima J, Klempir J, Motlı K J, Juhas S, and Ellederova Z

Subjects
Animals, Animals, Genetically Modified, Disease Models, Animal, Huntington Disease complications, Longitudinal Studies, Physical Conditioning, Animal, Stress, Psychological complications, Swine, Swine, Miniature, Tongue, Behavior, Animal physiology, Cognition physiology, Huntington Disease physiopathology, Motor Activity
Abstract

Huntington's disease (HD) is an inherited devastating neurodegenerative disease with no known cure to date. Several therapeutic treatments for HD are in development, but their safety, tolerability and efficacy need to be tested before translation to bedside. The monogenetic nature of this disorder has enabled the generation of transgenic animal models carrying a mutant huntingtin (mHTT) gene causing HD. A large animal model reflecting disease progression in humans would be beneficial for testing the potential therapeutic approaches. Progression of the motor, cognitive and behavioral phenotype was monitored in transgenic Huntington's disease minipigs (TgHD) expressing the N-terminal part of human mHTT. New tests were established to investigate physical activity by telemetry, and to explore the stress-induced behavioral and cognitive changes in minipigs. The longitudinal study revealed significant differences between 6- to 8-year-old TgHD animals and their wild-type (WT) controls in a majority of the tests. The telemetric study showed increased physical activity of 4.6- to 6.5-year-old TgHD boars compared to their WT counterparts during the lunch period as well as in the afternoon. Our phenotypic study indicates progression in adult TgHD minipigs and therefore this model could be suitable for longstanding preclinical studies of HD.This article has an associated First Person interview with the first author of the paper., Competing Interests: Competing interestsThe authors declare no competing or financial interests., (© 2019. Published by The Company of Biologists Ltd.)

Published
2019
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