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Parodontne bolesti i zubni karijes među najučestalijim su oralnim bolestima i glavni razlog gubitka zuba. Prevencija ovih bolesti smatra se prioritetom jer je isplativija od njihova liječenja. Dentalni plak glavni je čimbenik nastanka i razvoja parodontnih bolesti i zubnoga karijesa. Svakodnevno mehaničko uklanjanje dentalnoga plaka četkanjem važan je dodatak profesionalnom čišćenju zubnih naslaga i ključna je strategija u očuvanju oralnoga zdravlja. No, četkice za zube ne mogu sasvim prodrijeti u interdentalne prostore, gdje su parodontne bolesti i zubni karijes najčešći. Zato se sredstva za interdentalno čišćenje preporučuju kao dodatak redovitom četkanju, a najčešće su to zubni konac i interdentalne četkice. S ciljem procjene učinkovitosti i sigurnosti uporabe zubnoga konca i interdentalnih četkica, uz četkanje zubi, u prevenciji i kontroli parodontnih bolesti i zubnoga karijesa u odraslih provedena su dva Cochrane sustavna pregledna rada. Metodologija korištena u oba rada temeljena je na eksplicitnim metodama opisanim u Cochrane Priručniku za sustavne preglede intervencija (135). Prema unaprijed određenim kriterijima uključenja, u sustavne preglede uključeni su isključivo radomizirani kontrolirani pokusi. 12 studija je uključeno u sustavni pregledni rad o učinkovitosti uporabe zubnoga konca sa 582 ispitanika u skupini koja je koristila četkicu za zube i zubni konac i 501 ispitanik u kontrolnim skupinama. Pronađeni su dokazi o učinkovitosti uporabe zubnoga konca uz četkanje u smanjenju gingivitisa nakon jednog, tri i šest mjeseci te slabi i vrlo nepouzdani dokazi o njegovoj koristi u smanjenju dentalnoga plaka nakon jednog i tri mjeseca. Sedam studija uključeno je u sustavni pregled o učinkovitosti uporabe interdentalnih četkica sa 197 ispitanika u skupini koja je koristila četkice za zube i interdentalne četkice i 195 ispitanika u skupini koja je koristila četkice za zube i zubni konac. Uporaba interdentalnih četkica uz četkanje pokazala se korisnijom od samog četkanja u smanjenju gingivitisa i dentalnoga plaka nakon mjesec dana. U usporedbi sa zubnim koncem, interdentalne su četkice učinkovitije u ublažavanju gingivitisa nakon mjesec dana. Što se tiče dentalnoga plaka, nema dostatnih dokaza kojima bi se potvrdila korist ijednog od navedenih sredstava. Zbog nedosljednosti u izvještavanju, analiza podataka o štetnim učincima nije bila moguća. Nisu pronađene studije o učinkovitosti uporabe zubnoga konca i interdentalnih četkica u prevenciji karijesa kod odraslih., Periodontal diseases and dental caries are among the most common oral diseases and the main reason for tooth loss. Prevention of these diseases is of high priority considering the high cost of its treatment. Dental plaque is the main factor in the development and progression of periodontal diseases and dental caries. Daily mechanical plaque removal by toothbrushing is an important addition to professional plaque removal techniques and a key strategy for oral health maintenance. However, toothbrushes alone are unable to adequately penetrate interdental areas where periodontal diseases and dental caries are most commonly found. Therefore, interdental cleaning aids, namely dental floss and interdental brushes, have been recommended in addition to regular toothbrushing. In order to assess the efficacy and safety of flossing and interdental brushing, in addition to toothbrushing, in the prevention and control of periodontal diseases and dental caries in adults two Cochrane systematic reviews have been conducted. The methodology used in both reviews is based on the explicit methods described in the Cochrane Handbook for Systematic Reviews of Interventions. According to the predefined inclusion criteria, only RCTs were included in the reviews. 12 studie were included in the Flossing review with 582 participants in the toothbrushing and flossing group and 501 participants in the toothbrushing only control groups. There is evidence of the efficiency of flossing, in addition to toothbrushing, in the reduction of gingivitis at one, three and six months. However, only weak and unreliable evidence of its benefit in the reduction of dental plaque after one and three months have been found. Seven studies were included in the Interdental brushing review with 197 participants enrolled in the interdental brushing plus toothbrushing study arms and 195 participants in the flossing plus toothbrushing control groups. The use of interdental brushes in addition to toothbrushing has proved to be more beneficial than toothbrushing alone, in the reduction of gingivitis after one month. When compared to dental floss, interdental brushes are more efficient in reducing gingivitis after one month. As for dental plaque, there was insufficient evidence to claim a benefit for either of the interdental aids. Due to inconsistency in reporting, data analysis concerning adverse effects was not possible. No studies examining the efficiency of dental floss and interdental brushes in the prevention of caries in adults have been found.

BACKGROUND: The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach is a system for transparent evaluation of the certainty of evidence used in clinical practice guidelines and systematic reviews. GRADE is a key part of evidence-based medicine (EBM) training of health care professionals.OBJECTIVE: This study aimed to compare web-based and face-to-face methods of teaching the GRADE approach for evidence assessment.METHODS: A randomized controlled trial was conducted on 2 delivery modes of GRADE education integrated into a course on research methodology and EBM with third-year medical students. Education was based on the Cochrane Interactive Learning Interpreting the findings module, which had a duration of 90 minutes. The web-based group received the web-based asynchronous training, whereas the face-to-face group had an in-person seminar with a lecturer. The main outcome measure was the score on a 5-question test that assessed confidence interval interpretation and overall certainty of evidence, among others. Secondary outcomes included writing a recommendation for practice and course satisfaction.RESULTS: In all, 50 participants received the web-based intervention, and 47 participants received the face-to-face intervention. The groups did not differ in the overall scores for the Cochrane Interactive Learning test, with a median of 2 (95% CI 1.0-2.0) correct answers for the web-based group and 2 (95% CI 1.3-3.0) correct answers for the face-to-face group. Both groups gave the most correct answers to the question about rating a body of evidence (35/50, 70% and 24/47, 51% for the web-based and face-to-face group, respectively). The face-to-face group better answered the question about the overall certainty of evidence question. The understanding of the Summary of Findings table did not differ significantly between the groups, with a median of 3 correct answers to 4 questions for both groups (P=.352). The writing style for the recommendations for practice also did not differ between the 2 groups. Students' recommendations mostly reflected the strengths of the recommendations and focused on the target population, but they used passive words and rarely mentioned the setting for the recommendation. The language of the recommendations was mostly patient centered. Course satisfaction was high in both groups.CONCLUSIONS: Training in the GRADE approach could be equally effective when delivered asynchronously on the web or face-to-face.

Panel će dati osvrt na dosadašnji rad hrvatskoga Cochranea u području sinteze dokaza, edukacije i diseminacije znanja, ali i dati pogled u budućnost i potaknuti razgovor o mogućnostima za suradnju. Također, ovaj panel će naglasiti važnost interdisciplinarne suradnje i korištenja Cochraneovih sustavnih pregleda u planiranju razvoja fizikalne i rehabilitacijske medicine i predstaviti zanimljive recentne dokaze iz različitih područja rehabilitacijske medicine. Polje Cochrane Rehabilitation bilježi sjajne rezultate u sintezi i diseminaciji dokaza iz različitih područja fizikalne i rehabilitacijske medicine, čime uspješno premošćuje nedostatak u dokazima s kojima su se donedavno suočavali, ponajprije fizijatri, ali i svi ostali članovi rehabilitacijskoga tima. Panel će, stoga, predstaviti bogat spektar aktivnosti polja Cochrane Rehabilitation (CR) kojima CR ostvaruje komunikaciju utemeljenu na dokazima s relevantnim dionicima. Mrežne stranice CR-a (https://rehabilitation. cochrane.org), koje su ujedno i glavni komunikacijski alat polja CR, donose novosti, poveznice na relevantne publikacije i projekte, kao i sve važne informacije o radu CR-a i Cochranea općenito te predstavljaju izvanredno polazište u traženju odgovora na određena klinička pitanja i mogu poslužiti kao temelj za planiranje budućih istraživanja, ili znanstvenih projekata. Nadalje, CR komunicira dokaze putem društvenih mreža, izradom slikovnih sažetaka, tzv. blogshots, mjesečnim novinama, a napose s pomoću tzv. Cochrane Corners (CC), kojima informiraju članove rehabilitacijskoga tima o ključnim rezultatima Cochraneovih sustavnih pregleda uzimajući u obzir klinički kontekst, a sve s ciljem što učinkovitije primjene dokaza u rehabilitaciji i što boljih ishoda za bolesnike.

Introduction We studied the duration of adaptation to new complete dentures (CD) and changes for 5 years based on patients’ self-reported outcomes. Methodology Sixty fully edentulous patients who received new CDs and wore them for 5 years were included. A questionnaire (answers 0-10 VAS) related to self-perceived speech, chewing function, comfort of denture wearing, denture retention, and orofacial esthetics was completed on the 1st, 3rd, 8th, 15th, and 30th day after new CD delivery, and after 1, 3, and 5 years of denture wearing. Results Self-perceived speech reached the highest scores on the 30th day ; females and previous removable denture (RD) wearers adapted faster during the first days. Chewing reached the highest scores on the 30th day, remained unchanged over the 1st year, and decreased significantly afterwards ; females gave higher scores during the first 15 days and previous RD wearers from the 3rd till the 30th day. A comfort of denture wearing first slightly decreased, but soon increased, reaching the highest values the 30th day, remained unchanged after one year, then decreased gradually, with no significant difference between gender and previous RD experience. Retention scores decreased after 3 and 5 years, without difference between gender and previous RD experience. Orofacial esthetics scores decreased substantially after 3 years with no effect of gender and previous experience (p>0.05). Conclusion The highest scores were obtained for orofacial esthetics and speech, the lowest for chewing function. Participants needed 30 days to adapt to new CDs. The adaptation lasted one year and decreased significantly the 3rd and the 5th year.

Objectives: To assess dentists’ level of knowledge and practice concerning antibiotic usage in endodontics using the European Society of Endodontology position statement as a reference. Material and Methods: A cross-sectional study was conducted in the form of an electronic questionnaire consisting of 23 questions, including dentists’ demographic and professional characteristics, attitudes as well as experiences regarding antibiotics in endodontics. Data were evaluated by the Mann-Whit-ney test or the Kruskal Wallis 1-way ANOVA, α = 5%. Results: The overall mean self-reported knowl-edge of antibiotics usage in endodontics was 11.7±2.5 points, out of a maximum possible score of 23. The factors associated with a higher knowledge were: age (P≤0.001), clinical experience (P≤0.001), specialist training (P=0.008), and adherence to the guidance on the use of systemic antibiotics in endodontics (P=0.006). Dentists who specialized in endodontics (16.1±2.2) achieved higher levels of knowledge. Conclusion: Knowledge on antibiotic usage in endodontics among dentists in Croatia is insufficient. There is a need for continuing education on the use of antibiotics among general dentists.

A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%–99%; n = 4410), cough (61%, 95% CI 39%–81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%–55%; n = 3778), dyspnea (26%, 95% CI 12%–41%; n = 3700), headache in 12% (95% CI 4%–23%, n = 3598 patients), sore throat in 10% (95% CI 5%–17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%–17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 × 109/L, 95% CI 0.83–1.03 × 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54–45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%–1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.

Background: The Informed Health Choices (IHC) Project developed a list of key concepts to help people understand and judge trustworthiness of treatment claims, with 12 of the key concepts being included in the IHC primary school resources. Objectives: To evaluate attitudes of primary school teachers about 12 IHC key concepts intended for primary school children. Methods: The IHC key concepts were presented in primary school settings in urban agglomeration of the City of Split during county expert meetings and teachers’ school councils. We asked participating teachers to complete a questionnaire consisting of three parts. Demographic characteristics included teachers’ gender, age and work experience. For assessing their overall understanding of the presented concepts, teachers were asked to choose one of the following statements: Not understood, Somewhat understood, Understood, and Understood very well. Furthermore, based on their competencies and their interests, teachers were asked to use a Likert scale of 1 to 6 (1 = lowest, 6 = highest) and provide a numeric score regarding the four criteria: 1) relevance and importance, 2) usefulness, 3) understandability and 4) impact on children of each of the 12 key concepts for both third grade (age 9) and sixth grade (age 12) primary school children. The study was approved by the Ethics Committee of the University of Split School of Medicine and was funded by the Croatian Science Foundation project called “Professionalism in Health – Decision making in practice and research, ProDeM” under Grant agreement No. IP-2019-04-4882. Results: In total, 304 teachers completed the questionnaire. A total of 83.5% (N = 254) reported having understood the IHC key concepts well or very well (Figure 1). Participants’ median age was 42.5 (interquartile range 18), with 22.7% of teachers (N = 69) having five years of work experience or less, 15.79% (N = 48) from five to 10 years, and 61.51% (N = 187) more than 10 years of work experience. In relation to the four criteria, all concepts scored well with mean values ranging from 4.30 to 4.97 on a 1 to 6 scale for sixth grade children, and from 3.92 to 4.77 for third grade children (Table 1). Overall assessments of all four categories for each of the concepts were scored relatively high with mean values ranging from 17.65 ± 4.48 on a 4 to 24 scale to 19.44 ± 3.72 for sixth grade children, and from 16.58 ± 5.20 to 18.61 ± 4.26 for third grade children (Figure 2). Metric characteristics for the overall assessments of all concepts showed they were homogenous, confident (Cronbach alpha from 0.836 to 0.941) and sensitive. Conclusions: Most teachers understand IHC key concepts well. Teachers considered that teaching primary school children about the IHC concepts was relevant. Slightly lower assessments for the third grade children indicate that, in order to use the IHC key concepts for teaching at this level of primary education, it necessary to explore means of adapting and simplifying the teaching materials.

Introduction: Adopting a healthy lifestyle early in life is crucially important for preserving health, preventing non-communicable diseases and increasing quality of life in adulthood and old age. Unfortunately, overweight and obesity rates continue to rise in all regions of the world, especially in children, with an estimate of 40 million children under five, 131 million children between 5 and 9 years old, and 207 million adolescents being overweight (1). This is mostly driven by nutritional transition (2), and reduced physical activity levels (3). The aim of this study was to investigate the habits of high school students in Split, Croatia. Methods: We examined the prevalence of unhealthy behaviors (smoking, infrequent vegetables and fruits consumption, frequent consumption of processed meat, sweets and sodas, inadequate sleep and low physical activity, assessed by the International Physical Activity Questionnaire-Short Form (IPAQ), in adolescents aged 16-18 years attending 7 high schools in the City of Split. Results: We surveyed 881 students (558 girls, 323 boys ; response rate of 87%), during March-May 2019. Average BMI was 21.5±2.7 kg/m2, and 22% of students reported being active smokers (ranging from 7% to 35%, depending on the school), and 11% were ex-smokers. The average duration of sleep during working days was 7.5 h (IQR 1.5), and 44% of students slept

Background: Since 2012, the Croatian Ministry of Science and Education has been funding projects for the ‘Popularisation of Science’. After successfully applying for funding for the translation of Cochrane plain language Summaries (2012 to 2014), which enabled Cochrane Croatia to establish the Croatian Translation Project, we decided to broaden our perspective and apply for funding for translation of Cochrane podcasts. Cochrane podcasts deliver a summary of the latest Cochrane evidence in an easy to access audio format. Objectives: To translate and record all available Cochrane podcasts into Croatian. Methods: We received funding from the Croatian Ministry of Science and Education in 2015 and 2016 for the translation, recording, and promotion of Cochrane podcasts. The Cochrane Knowledge Translation (KT) Department provided a list of available podcast texts for translation. Members of Cochrane Croatia and six partner organisations chose topics of interest. Once texts were carefully translated and written in the third person, our Quality Assurance Co-ordinator, Prof Matko Marušić, edited them. Finally, the Podcasts were recorded, either by the translator - if willing and available - or by members of Cochrane Croatia. Edited recordings were then sent to Paolo Rosati, of Cochrane’s Informatics & Technology (IT) Service, for publication on Cochrane.org. In addition, recordings of translated Cochrane podcasts were sent to a regional radio station, where they are aired regularly. Results: By February 2018, 34 Cochrane podcasts had been translated, recorded, and published on Cochrane.org. A further 55 are underway. We produced a flyer for Cochrane podcasts with the assistance of Cochrane’s KT Department, which can be found on Cochrane Croatia’s website and the Cochrane Community website. Five of the six partner organisations invited to participate in this project did contribute ; three of them are patient/consumer organisations. The translated podcasts were presented at the 9th Croatian Cochrane Symposium. Conclusions: The translation and recording of Cochrane podcasts is a fun, innovative, team-building way of involving patients/consumers in knowledge translation, hence making Cochrane evidence available to a wider audience. Patient or healthcare consumer involvement: Consumers and patients have been involved in this initiative from the outset.

In adult patients suffering from Acute Coronary Syndrome, can Ivabradine, used alone or in combination with usual care (β-blocker) reduce the mortality rate compared to the usual care (β- blocker) only.

BACKGROUND: In recent years, the clinical use of mandibular advancement device (MAD) for the treatment of obstructive sleep apnea (OSA) patients has remarkably increased. Although well tolerated, MAD may cause certain side effects. The aim of this study was to investigate potential adverse effects of the custom-made adjustable MAD on occlusal changes after 1 year of treatment. METHODS: A total of 15 patients with mild to moderate OSA were treated with custom-made adjustable MAD (Silensor-sl, Erkodent, Pfalzgrafenweiler, Germany) and they were followed-up after 1 year of treatment. Sleep studies were performed at baseline without the MAD and after 1 year of treatment with the MAD in situ. Lateral cephalometric radiographs were taken for each patient using standardized techniques at baseline and after 1 year of MAD treatment and standard cephalometric analyses were performed using AudaxCeph software (Audax, Ljubljana, Slovenia). RESULTS: The mean apnea-hypopnea index (AHI) decreased significantly from 22.9±5.9 at baseline to 9.7±4.5 episode/h after 1 year of treatment (P

Parodontne bolesti i zubni karijes među najučestalijim su oralnim bolestima i glavni razlog gubitka zuba. Prevencija ovih bolesti smatra se prioritetom jer je isplativija od njihova liječenja. Dentalni plak glavni je čimbenik nastanka i razvoja parodontnih bolesti i zubnoga karijesa. Svakodnevno mehaničko uklanjanje dentalnoga plaka četkanjem važan je dodatak profesionalnom čišćenju zubnih naslaga i ključna je strategija u očuvanju oralnoga zdravlja. No, četkice za zube ne mogu sasvim prodrijeti u interdentalne prostore, gdje su parodontne bolesti i zubni karijes najčešći. Zato se sredstva za interdentalno čišćenje preporučuju kao dodatak redovitom četkanju, a najčešće su to zubni konac i interdentalne četkice. S ciljem procjene učinkovitosti i sigurnosti uporabe zubnoga konca i interdentalnih četkica, uz četkanje zubi, u prevenciji i kontroli parodontnih bolesti i zubnoga karijesa u odraslih provedena su dva Cochrane sustavna pregledna rada. Metodologija korištena u oba rada temeljena je na eksplicitnim metodama opisanim u Cochrane Priručniku za sustavne preglede intervencija (135). Prema unaprijed određenim kriterijima uključenja, u sustavne preglede uključeni su isključivo radomizirani kontrolirani pokusi. 12 studija je uključeno u sustavni pregledni rad o učinkovitosti uporabe zubnoga konca sa 582 ispitanika u skupini koja je koristila četkicu za zube i zubni konac i 501 ispitanik u kontrolnim skupinama. Pronađeni su dokazi o učinkovitosti uporabe zubnoga konca uz četkanje u smanjenju gingivitisa nakon jednog, tri i šest mjeseci te slabi i vrlo nepouzdani dokazi o njegovoj koristi u smanjenju dentalnoga plaka nakon jednog i tri mjeseca. Sedam studija uključeno je u sustavni pregled o učinkovitosti uporabe interdentalnih četkica sa 197 ispitanika u skupini koja je koristila četkice za zube i interdentalne četkice i 195 ispitanika u skupini koja je koristila četkice za zube i zubni konac. Uporaba interdentalnih četkica uz četkanje pokazala se korisnijom od samog četkanja u smanjenju gingivitisa i dentalnoga plaka nakon mjesec dana. U usporedbi sa zubnim koncem, interdentalne su četkice učinkovitije u ublažavanju gingivitisa nakon mjesec dana. Što se tiče dentalnoga plaka, nema dostatnih dokaza kojima bi se potvrdila korist ijednog od navedenih sredstava. Zbog nedosljednosti u izvještavanju, analiza podataka o štetnim učincima nije bila moguća. Nisu pronađene studije o učinkovitosti uporabe zubnoga konca i interdentalnih četkica u prevenciji karijesa kod odraslih. Periodontal diseases and dental caries are among the most common oral diseases and the main reason for tooth loss. Prevention of these diseases is of high priority considering the high cost of its treatment. Dental plaque is the main factor in the development and progression of periodontal diseases and dental caries. Daily mechanical plaque removal by toothbrushing is an important addition to professional plaque removal techniques and a key strategy for oral health maintenance. However, toothbrushes alone are unable to adequately penetrate interdental areas where periodontal diseases and dental caries are most commonly found. Therefore, interdental cleaning aids, namely dental floss and interdental brushes, have been recommended in addition to regular toothbrushing. In order to assess the efficacy and safety of flossing and interdental brushing, in addition to toothbrushing, in the prevention and control of periodontal diseases and dental caries in adults two Cochrane systematic reviews have been conducted. The methodology used in both reviews is based on the explicit methods described in the Cochrane Handbook for Systematic Reviews of Interventions. According to the predefined inclusion criteria, only RCTs were included in the reviews. 12 studie were included in the Flossing review with 582 participants in the toothbrushing and flossing group and 501 participants in the toothbrushing only control groups. There is evidence of the efficiency of flossing, in addition to toothbrushing, in the reduction of gingivitis at one, three and six months. However, only weak and unreliable evidence of its benefit in the reduction of dental plaque after one and three months have been found. Seven studies were included in the Interdental brushing review with 197 participants enrolled in the interdental brushing plus toothbrushing study arms and 195 participants in the flossing plus toothbrushing control groups. The use of interdental brushes in addition to toothbrushing has proved to be more beneficial than toothbrushing alone, in the reduction of gingivitis after one month. When compared to dental floss, interdental brushes are more efficient in reducing gingivitis after one month. As for dental plaque, there was insufficient evidence to claim a benefit for either of the interdental aids. Due to inconsistency in reporting, data analysis concerning adverse effects was not possible. No studies examining the efficiency of dental floss and interdental brushes in the prevention of caries in adults have been found.

Cilj istraživanja: Ispitati učestalost patoloških lezija oralne sluznice, suspektnih potencijalno malignih oralnih lezija te lezija suspektnih na oralni karcinom u osoba koje su se odazvale pregledu u svrhu ranog otkrivanja oralnog karcinoma prilikom obilježavanja Svjetskog tjedna svjesnosti o karcinomu usne šupljine, glave i vrata u travnju 2022. i 2023. godine u ambulanti za oralnu medicinu KBC-a Split. Materijali i metode: U istraživanju je dobrovoljno sudjelovalo 440 ispitanika koji su se odazvali na preventivni pregled u svrhu ranog otkrivanja oralnog karcinoma u sklopu organiziranog Dana otvorenih vrata. Raspon dobi ispitanika je od 18 do 93 godine. Svim ispitanicima uzeta je detaljna anamneza. Prilikom neinvazivnog kliničkog pregleda usne šupljine zabilježeni su podatci o stanju oralne sluznice te o vrsti lezije koja je pronađena. Pacijenti kojima su pronađene patološke promjene u usnoj šupljini upućeni su na daljnju specijalističku obradu. Oni ispitanici kod kojih je pronađena lezija suspektna na karcinom upućeni su na maksilofacijalnu kirurgiju kako bi se napravila biopsija i patohistološka analiza lezije. Rezultati: U istraživanju je sudjelovalo 208 (47,3 %) muškaraca i 232 (52,7 %) žene. Srednja vrijednost dobi iznosila je 62,8 dok je medijan bio 66 godina. Pronađenih prekanceroza bilo je ukupno 32 (7,3%). Od toga su 23 (5,2 %) klinička nalaza imponirala erozivnim formama oralnoga lihen planusa. Sedam (1,6 %) patoloških promjena bilo je suspektno na karcinom. Na pitanje o svakodnevnoj konzumaciji alkohola 112 (25,5 %) ih je odgovorilo potvrdno, dok se 104 (23,6 %) izjasnilo kao pušači. Zaključci: Patološka promjena koja je suspektna na karcinom pronađena je u sedam ispitanika od pregledanih 440. U ovome istraživanju pronađeno je ukupno 117 patoloških promjena sluznice, od čega su 32 okarakterizirane kao potencijalno maligna lezija. Najčešće pronađena potencijalno maligna lezija bio je erozivni oblik oralnog lihen planusa. Ukupno su 104 ispitanika zahtijevala dodatni specijalistički pregled, što je za većinu bio pregled specijalista oralne medicine. Od sedmero ispitanika kod kojih je pronađena lezija suspektna na karcinom njih četvero negira konzumaciju alkohola i duhanskih proizvoda., Objectives: To examine the frequency of pathological lesions of the oral mucosa, suspected potentially malignant oral lesions and lesions suspicious for oral cancer in persons who responded to the examination for early detection of oral cancer during the promoting of the Oral, Head and Neck Cancer Awareness Week in April 2022 and 2023. in the clinic for oral medicine of the University Hospital of Split. Materials and methods: 440 subjects, who responded to a preventive examination for early detection of oral cancer as part of the organized Open Day, voluntarily participated in the research. The age range of the respondents is from 18 to 93 years. A detailed medical history was taken from all subjects. During the non-invasive clinical examination of the oral cavity, data on the condition of the oral mucosa and the type of lesion that was found were recorded. Patients who were found to have a pathological lesion of the oral cavity were referred for further specialist treatment. Subjects who were found to have a lesion suspicious of cancer were referred to the clinic for maxillofacial surgery in order to perform a biopsy and pathohistological analysis of the lesion. Results: 208 (47.3%) men and 232 (52.7%) women participated in the research. The mean age was 62.8, while the median was 66 years. A total of 32 (7.3%) precancerous lesions were found. Of these, 23 (5.2%) had clinical findings of erosive forms of oral lichen planus. Seven (1.6%) pathological changes were associated with oral cancer. When asked about daily alcohol consumption, 112 (25.5%) answered yes, while 104 (23.6%) declared themselves as smokers. Conclusion: A pathological change suspicious of cancer was found in seven subjects out of 440 examined. In this study, a total of 117 pathological changes of the mucous membrane were found, of which 32 were characterized as potentially malignant lesions. The most frequently found potentially malignant lesion was the erosive form of oral lichen planus. A total of 104 respondents required an additional specialist examination, which for the majority was an examination by an oral medicine specialist. Of the seven subjects in whom a lesion suspicious of cancer was found, four of them denied the consumption of alcohol and tobacco products.