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284 results on '"Poisbeau, Pierrick"'

5. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Author

Wahis, Jérôme, Baudon, Angel, Althammer, Ferdinand, Kerspern, Damien, Goyon, Stéphanie, Hagiwara, Daisuke, Lefevre, Arthur, Barteczko, Lara, Boury-Jamot, Benjamin, Bellanger, Benjamin, Abatis, Marios, Da Silva Gouveia, Miriam, Benusiglio, Diego, Eliava, Marina, Rozov, Andrei, Weinsanto, Ivan, Knobloch-Bollmann, Hanna Sophie, Kirchner, Matthew K., Roy, Ranjan K., Wang, Hong, Pertin, Marie, Inquimbert, Perrine, Pitzer, Claudia, Siemens, Jan, Goumon, Yannick, Boutrel, Benjamin, Lamy, Christophe Maurice, Decosterd, Isabelle, Chatton, Jean-Yves, Rouach, Nathalie, Young, W. Scott, Stern, Javier E., Poisbeau, Pierrick, Stoop, Ron, Darbon, Pascal, Grinevich, Valery, and Charlet, Alexandre

Published
2021
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12. Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine

Author

Charlet, Alexandre, Muller, Arnaud H, Laux, Alexis, Kemmel, Véronique, Schweitzer, Annie, Deloulme, Jean-Christophe, Stuber, Denise, Delalande, François, Bianchi, Enrica, Van Dorsselaer, Alain, Aunis, Dominique, Andrieux, Annie, Poisbeau, Pierrick, and Goumon, Yannick

Abstract

Abstract Background- Mice deficient for the stable tubule only peptide (STOP) display altered dopaminergic neurotransmission associated with severe behavioural defects including disorganized locomotor activity. Endogenous morphine, which is present in nervous tissues and synthesized from dopamine, may contribute to these behavioral alterations since it is thought to play a role in normal and pathological neurotransmission. Results- In this study, we showed that STOP null brain structures, including cortex, hippocampus, cerebellum and spinal cord, contain high endogenous morphine amounts. The presence of elevated levels of morphine was associated with the presence of a higher density of mu opioid receptor with a higher affinity for morphine in STOP null brains. Interestingly, STOP null mice exhibited significantly lower nociceptive thresholds to thermal and mechanical stimulations. They also had abnormal behavioural responses to the administration of exogenous morphine and naloxone. Low dose of morphine (1 mg/kg, i.p.) produced a significant mechanical antinociception in STOP null mice whereas it has no effect on wild-type mice. High concentration of naloxone (1 mg/kg) was pronociceptive for both mice strain, a lower concentration (0.1 mg/kg) was found to increase the mean mechanical nociceptive threshold only in the case of STOP null mice. Conclusions- Together, our data show that STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain. This was correlated with hypernociception and impaired pharmacological sensitivity to mu opioid receptor ligands.

Published
2010

16. Additional file 1 of Effect of an intraoperative periradicular application of platelet-rich fibrin (PRF) on residual post-surgical neuropathic pain after disc herniation surgery: study protocol for NeuroPRF, a randomized controlled trial

Author

Todeschi, Julien, Dannhoff, Guillaume, Coca, Andres Hugo, Timbolschi, Daniel Ionut, Proust, François, Lefebvre, François, Lelievre, Vincent, Poisbeau, Pierrick, Vallat, Laurent, Salvat, Eric, and Bohren, Yohann

Abstract

Additional file 1. The right of access to source data and documents.

Published
2023
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20. Identification of bacterial lipopeptides as key players in IBS

Author

Petitfils, Camille, primary, Maurel, Sarah, additional, Payros, Gaelle, additional, Hueber, Amandine, additional, Agaiz, Bahija, additional, Gazzo, Géraldine, additional, Marrocco, Rémi, additional, Auvray, Frédéric, additional, Langevin, Geoffrey, additional, Motta, Jean-Paul, additional, Floch, Pauline, additional, Tremblay-Franco, Marie, additional, Galano, Jean-Marie, additional, Guy, Alexandre, additional, Durand, Thierry, additional, Lachambre, Simon, additional, Durbec, Anaëlle, additional, Hussein, Hind, additional, Decraecker, Lisse, additional, Bertrand-Michel, Justine, additional, Saoudi, Abdelhadi, additional, Oswald, Eric, additional, Poisbeau, Pierrick, additional, Dietrich, Gilles, additional, Melchior, Chloe, additional, Boeckxstaens, Guy, additional, Serino, Matteo, additional, Le Faouder, Pauline, additional, and Cenac, Nicolas, additional

Published
2022
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23. Effect of Virtual Reality Hypnosis on Pain Threshold and Neurophysiological and Autonomic Biomarkers in Healthy Volunteers: Prospective Randomized Crossover Study

Author

Terzulli, Claire, primary, Melchior, Meggane, additional, Goffin, Laurent, additional, Faisan, Sylvain, additional, Gianesini, Coralie, additional, Graff, Denis, additional, Dufour, André, additional, Laroche, Edouard, additional, Chauvin, Chloé, additional, and Poisbeau, Pierrick, additional

Published
2022
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34. Effect of virtual reality hypnosis on pain threshold, neurophysiological and autonomic biomarkers in healthy volunteers: a prospective randomized cross-over study. (Preprint)

Author

Terzulli, Claire, primary, Melchior, Meggane, additional, Goffin, Laurent, additional, Faisan, Sylvain, additional, Gianesini, Coralie, additional, Graff, Denis, additional, Dufour, André, additional, Laroche, Edouard, additional, Chauvin, Chloé, additional, and Poisbeau, Pierrick, additional

Published
2021
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36. Identification of bacterial lipopeptides as key players in IBS

Author

Petitfils, Camille, Maurel, Sarah, Payros, Gaelle, Hueber, Amandine, Agaiz, Bahija, Gazzo, Géraldine, Marrocco, Rémi, Auvray, Frédéric, Langevin, Geoffrey, Motta, Jean-Paul, Floch, Pauline, Tremblay-Franco, Marie, Galano, Jean-Marie, Guy, Alexandre, Durand, Thierry, Lachambre, Simon, Durbec, Anae¨lle, Hussein, Hind, Decraecker, Lisse, Bertrand-Michel, Justine, Saoudi, Abdelhadi, Oswald, Eric, Poisbeau, Pierrick, Dietrich, Gilles, Melchior, Chloe, Boeckxstaens, Guy, Serino, Matteo, Le Faouder, Pauline, and Cenac, Nicolas

Abstract

ObjectivesClinical studies revealed that early-life adverse events contribute to the development of IBS in adulthood. The aim of our study was to investigate the relationship between prenatal stress (PS), gut microbiota and visceral hypersensitivity with a focus on bacterial lipopeptides containing γ-aminobutyric acid (GABA).DesignWe developed a model of PS in mice and evaluated, in adult offspring, visceral hypersensitivity to colorectal distension (CRD), colon inflammation, barrier function and gut microbiota taxonomy. We quantified the production of lipopeptides containing GABA by mass spectrometry in a specific strain of bacteria decreased in PS, in PS mouse colons, and in faeces of patients with IBS and healthy volunteers (HVs). Finally, we assessed their effect on PS-induced visceral hypersensitivity.ResultsPrenatally stressed mice of both sexes presented visceral hypersensitivity, no overt colon inflammation or barrier dysfunction but a gut microbiota dysbiosis. The dysbiosis was distinguished by a decreased abundance of Ligilactobacillus murinus, in both sexes, inversely correlated with visceral hypersensitivity to CRD in mice. An isolate from this bacterial species produced several lipopeptides containing GABA including C14AsnGABA. Interestingly, intracolonic treatment with C14AsnGABA decreased the visceral sensitivity of PS mice to CRD. The concentration of C16LeuGABA, a lipopeptide which inhibited sensory neurons activation, was decreased in faeces of patients with IBS compared with HVs.ConclusionPS impacts the gut microbiota composition and metabolic function in adulthood. The reduced capacity of the gut microbiota to produce GABA lipopeptides could be one of the mechanisms linking PS and visceral hypersensitivity in adulthood.

Published
2023
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40. Astrocytes mediate oxytocin's effect on central amygdala circuitry that regulates emotional behavior in rodents

Author

Wahis, Jérôme, Baudon, Angel, Althammer, Ferdinand, Kerspern, Damien, Goyon, Stéphanie, Hagiwara, Daisuke, Lefevre, Arthur, Barteczko, Lara, Boury-Jamot, Benjamin, Bellanger, Benjamin, Abatis, Marios, Silva da Gouveia, Miriam, Benusiglio, Diego, Eliava, Marina, Rozov, Andrej, Weinsanto, Ivan, Knobloch-Bollmann, Hanna, Kirchner, Matthew, Roy, Ranjan, Wang, Hong, Pertin, Marie, Inquimbert, Perrine, Pitzer, Claudia, Siemens, Jan, Goumon, Yannick, Boutrel, Benjamin, Lamy, Christophe, Decosterd, Isabelle, Chatton, Jean-Yves, Rouach, Nathalie, Young, Scott, Stern, Javier, Poisbeau, Pierrick, Stoop, Ron, Darbon, Pascal, Grinevich, Valery, Charlet, Alexandre, Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), VIB-KU Leuven Center for Brain & Disease Research [Leuven, Belgium], Georgia State University, University System of Georgia (USG), Universität Heidelberg [Heidelberg], Lausanne University Hospital, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Harvard University [Cambridge], University of Freiburg [Freiburg], Chinese Academy of Sciences [Beijing] (CAS), University of Geneva [Switzerland], University of Lausanne (UNIL), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collège de France (CdF (institution)), Université Paris sciences et lettres (PSL), National Institutes of Health [Bethesda] (NIH), University of Heidelberg, Medical Faculty, and University of Strasbourg Institute of Advanced Study (USIAS)

Subjects
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Abstract

International audience; Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala (CeA), the release of OT modulates inhibitory circuits and thereby suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain-and loss-of-function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes express OT receptors and mediate anxiolytic and positive reinforcement effects of OT in the CeA of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlight astrocytes as essential components for modulation of emotional states under normal but also chronic pain conditions.

Published
2021

43. Endogenous morphine-6-glucuronide (M6G) is present in the plasma of patients: Validation of a specific anti-M6G antibody for clinical and basic research

Author

Laux-Biehlmann, Alexis, Chung, Hélène, Mouheiche, Jinane, Vérièpe, Julie, Delalande, François, Lamshöft, Marc, Welters, Ingeborg D., Soldevila, Stéphanie, Bazin, Hervé, Lamarque, Laurent, Dorsselaer, Alain Van, Poisbeau, Pierrick, Schneider, Francis, Goumon, Yannick, and Garnero, Patrick

Published
2014
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44. The burden of early life stress on the nociceptive system development and pain responses.

Author

Melchior, Meggane, Kuhn, Pierre, Poisbeau, Pierrick, and Robinson, Oliver

Subjects
SYSTEMS development, NEWBORN infants, PREMATURE infants, CHRONIC pain, PSYCHOLOGICAL stress
Abstract

For a long time, the capacity of the newborn infant to feel pain was denied. Today it is clear that the nociceptive system, even if still immature, is functional enough in the newborn infant to elicit pain responses. Unfortunately, pain is often present in the neonatal period, in particular in the case of premature infants which are subjected to a high number of painful procedures during care. These are accompanied by a variety of environmental stressors, which could impact the maturation of the nociceptive system. Therefore, the question of the long‐term consequences of early life stress is a critical question. Early stressful experience, both painful and non‐painful, can imprint the nociceptive system and induce long‐term alteration in brain function and nociceptive behavior, often leading to an increase sensitivity and higher susceptibility to chronic pain. Different animal models have been developed to understand the mechanisms underlying the long‐term effects of different early life stressful procedures, including pain and maternal separation. This review will focus on the clinical and preclinical data about early life stress and its consequence on the nociceptive system. [ABSTRACT FROM AUTHOR]

Published
2022
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49. GlyR α3: an essential target for spinal PG[E.sub.2]-mediated inflammatory pain sensitization

Author

Harvey, Robert J., Depner, Ulrike B., Wassle, Heinz, Ahmadi, Seifollah, Heindl, Cornelia, Reinold, Heiko, Smart, Trevor G., Harvey, Kirsten, Schutz, Burkhard, Abo-Salem, Osama M., Zimmer, Andreas, Poisbeau, Pierrick, Welzl, Hans, Wolfer, David P., Betz, Heinrich, Zeilhofer, Hanns Ulrich, and Muller, Ulrike

Subjects
Nervous system -- Research -- Physiological aspects, Pain -- Physiological aspects -- Research, Science and technology, Physiological aspects, Research
Abstract

Prostaglandin [E.sub.2](PG[E.sub.2]) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PG[E.sub.2]-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that GlyR α3 is distinctly expressed in superficial layers of the spinal cord dorsal horn. Mice deficient in GlyR α3 not only lack the inhibition of glycinergic neurotransmission by PG[E.sub.2] seen in wild-type mice but also show a reduction in pain sensitization induced by spinal PG[E.sub.2] injection or peripheral inflammation. Thus, GlyR α3 may provide a previously unrecognized molecular target in pain therapy., An exaggerated sensation of pain is a cardinal symptom of inflammation. It can result from either increased excitability of primary afferent nociceptive nerve fibers (peripheral sensitization) or changes in the [...]

Published
2004

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