1. Individual mapping of innate immune cell activation is a candidate marker of patient-specific trajectories of disability worsening in Multiple Sclerosis
- Author
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Bodini, B, Poirion, E, Tonietto, M, Benoit, C, Palladino, R, Maillart, E, Portera, E, Battaglini, M, Bera, G, Kuhnast, B, Louapre, C, Bottlaender, M, and Stankoff, B
- Subjects
Nuclear Medicine & Medical Imaging ,PET ,Neurology ,Image Processing ,fungi ,microglia ,1103 Clinical Sciences ,worsening disability ,disability worsening ,multiple sclerosis ,TSPO ,Positron Emission Tomography - Abstract
Objective: To develop a novel approach to generate individual maps of white matter (WM) innate immune cell activation using 18F-DPA-714 translocator protein (TSPO) positron emission tomography (PET), and to explore the relationship between these maps and individual trajectories of disability worsening in patients with multiple sclerosis (MS). Methods: Patients with MS (n = 37), whose trajectories of disability worsening over the 2 years preceding study entry were calculated, and healthy controls (n = 19) underwent magnetic resonance magnetic and 18F-DPA-714 PET. A threshold of significant activation of 18F-DPA-714 binding was calculated with a voxel-wise randomized permutation-based comparison between patients and controls, and used to classify each WM voxel in patients as characterized by a significant activation of innate immune cells (DPA+) or not. Individual maps of innate immune cell activation in the WM were employed to calculate the extent of activation in WM regions-of-interests and to classify each WM lesion as "DPA-active", "DPA-inactive" or "unclassified". Results: Compared with the WM of healthy controls, patients with MS had a significantly higher percentage of DPA+ voxels in the normal-appearing WM, (NAWM in patients=24.9±9.7%; WM in controls=14.0±7.8%, p more...
- Published
- 2019