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1,323 results on '"Poinsignon, A."'

1. Improving genetic testing pathways for transthyretin amyloidosis in France: challenges and strategies

Author

Bérénice Hebrard, Marie-Lise Babonneau, Philippe Charron, Emilie Consolino, Benjamin Dauriat, Delphine Dupin-Deguine, Dominique Fargeaud, Agnès Farrugia, Anna-Gaëlle Giguet-Valard, Damien Guijarro, Jocelyn Inamo, Julien Jeanneteau, Jean-Michaël Mazzella, Claire-Cécile Michon, Gilles Millat, Frédéric Mouquet, Silvia Oghina, Yann Pereon, Vianney Poinsignon, Julie Pompougnac, Julie Proukhnitzky, Elise Schaefer, Franck Sturtz, Mathilde Trosdorf, Anne Auguste, Giorgia Canali, Alexandre Combes, Benoît Funalot, and Thibaud Damy

Subjects
ATTR, Genetic testing, Rare disease, Multidisciplinary expert group, Experts’ consensus, Medicine
Abstract

Abstract Transthyretin amyloidosis (ATTR) is a severe and rare disease characterized by the progressive deposition of misfolded transthyretin proteins, causing irreversible organ damage. Transthyretin amyloidosis can present as a hereditary ATTR or acquired wild-type ATTR form. Genetic testing is critical for determining a hereditary predisposition and subsequently initiating appropriate family screening. In France, strict regulations govern genetic testing that aim to protect patients and their families affected by hereditary diseases such as ATTR. However, challenges persist in establishing an effective genetic testing pathway. A multidisciplinary group of French experts convened to discuss the challenges associated with an ATTR genetic diagnosis and to propose improvement strategies. Key challenges include the lack of pathway standardization, communication gaps between healthcare professionals (HCPs) and patients, and difficulties in complying with regulatory requirements. Concerns about patient data safety and outsourced testing quality further complicate matters. Proposed strategies included the development of stakeholder mapping tools for HCPs and patients, educational programs to improve literacy on genetic testing regulations, increase disease awareness among medical geneticists and genetic counselors, and strengthening HCP-patient communication through educational materials. These initiatives aim to streamline the genetic testing pathway, enhance compliance with regulations, and ultimately provide optimal support for patients and families with ATTR.

Published
2024
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2. Improving genetic testing pathways for transthyretin amyloidosis in France: challenges and strategies

Author

Hebrard, Bérénice, Babonneau, Marie-Lise, Charron, Philippe, Consolino, Emilie, Dauriat, Benjamin, Dupin-Deguine, Delphine, Fargeaud, Dominique, Farrugia, Agnès, Giguet-Valard, Anna-Gaëlle, Guijarro, Damien, Inamo, Jocelyn, Jeanneteau, Julien, Mazzella, Jean-Michaël, Michon, Claire-Cécile, Millat, Gilles, Mouquet, Frédéric, Oghina, Silvia, Pereon, Yann, Poinsignon, Vianney, Pompougnac, Julie, Proukhnitzky, Julie, Schaefer, Elise, Sturtz, Franck, Trosdorf, Mathilde, Auguste, Anne, Canali, Giorgia, Combes, Alexandre, Funalot, Benoît, and Damy, Thibaud

Published
2024
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7. Implication of agricultural practices in the micro-geographic heterogeneity of malaria transmission in Bouna, Côte d’Ivoire

Author

Obo Armel-Hermann Beke, Serge-Brice Assi, Akedjro Paul Harvey Kokrasset, Kacou Jean Denis Dibo, Méa Antoine Tanoh, Mathias Danho, Franck Remoué, Guibehi Benjamin Koudou, and Anne Poinsignon

Subjects
Malaria, Hotspot, Microgeographic heterogeneity, Agriculture practices, Anopheles exposure, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Wetlands and irrigated agricultural crops create potential breeding sites for Anopheles mosquitoes, leading to a heterogeneity in malaria transmission. In agricultural areas, heterogeneity of malaria transmission is often associated with the presence of hotspots consisting of localized clusters of higher transmission intensity. This study aims to identify micro-geographic hotspots of malaria transmission in an agricultural setting using a multidisciplinary approach. Methods Two cross-sectional surveys were conducted at the end of the dry season and at the peak of the rainy season in rural and urban sites in Bouna, northeastern Côte d'Ivoire. A total of 296 individuals from 148 farming households were randomly selected and sociological, geographical, entomological, and clinical data as well as blood samples were collected during each visit. Parasitological data and Anopheles exposure (measured using entomological and immunological methods) were compared with demographic, agricultural, and geographic data to identify drivers of malaria transmission. Heat maps combining these data were used to identify households with ongoing malaria transmission throughout the year. Results In rural areas, Plasmodium prevalence was consistent between the dry and the rainy seasons, with roughly half of the population infected. In urban areas, malaria transmission indicators were lower, with a parasite prevalence of less than 20%, which remained comparable between the dry and the rainy season. The presence of irrigated crops and proximity to wetlands were associated with increased Anopheles exposure. By mapping Plasmodium infection and Anopheles exposure, two different types of hotspots of malaria transmission were identified: micro-geographical scale and local scale hotspots. Conclusions The presence of wetlands in urban areas and irrigated agriculture in rural areas resulted in heterogeneity in malaria transmission on a micro-geographical scale. These specific households present particular risk of malaria transmission and could fuel malaria transmission in surrounding households. The identification of micro-geographical areas using heat maps combining several epidemiological parameters can help to identify hotspots of malaria transmission. The implementation of malaria control measures, such as seasonal chemoprophylaxis or vector control, in these areas could help to reduce the incidence of malaria and facilitate its elimination.

Published
2023
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8. Mosquito bites and stage-specific antibody responses against Plasmodium falciparum in southern Ghana

Author

Sebastian Shine Kwapong, Kwame Kumi Asare, Kwadwo Asamoah Kusi, Faustina Pappoe, Nicaise Ndam, Rachida Tahar, Anne Poinsignon, and Linda Eva Amoah

Subjects
Plasmodium falciparum, Circumsporozoite surface protein (PfCSP), Erythrocyte binding antigen 175 (PfEBA175), Anopheles gambiae salivary protein gSG6 peptide 1 (gSG6-P1), Malaria transmission, Ghana, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The human host elicits specific immune responses after exposure to various life stages of the malaria parasite as well as components of mosquito saliva injected into the host during a mosquito bite. This study describes differences in IgG responses against antigens derived from the sporozoite (PfCSP), asexual stage parasite (PfEBA175) and the gametocyte (Pfs230), in addition to an Anopheles gambiae salivary gland antigen (gSG6-P1), in two communities in Ghana with similar blood stage malaria parasite prevalence. Methods This study used archived plasma samples collected from an earlier cross-sectional study that enrolled volunteers aged from 6 months to 70 years from Simiw, peri-urban community (N = 347) and Obom, rural community (N = 291). An archived thick and thin blood smear for microscopy was used for the estimation of Plasmodium parasite density and species and DNA extraction from blood spots and P. falciparum confirmation was performed using PCR. This study used the stored plasma samples to determine IgG antibody levels to P. falciparum and Anopheles salivary antigens using indirect ELISA. Results Individuals from Simiw had significantly higher levels of IgG against mosquito gSG6-P1 [median (95%CI)] [2.590 (2.452–2.783) ng/mL] compared to those from Obom [2.119 (1.957–2.345) ng/mL], p 0.05). Conclusion In conclusion, the study showed that participants from Simiw had higher concentrations of circulating gSG6-P1 IgG antibodies but lower concentrations of P. falciparum antibodies, PfCSP IgG and Pfs230proC IgG compared to participants from Obom.

Published
2023
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13. Host-microbiota relationship in the pathophysiology of aseptic abscess syndrome: protocol for a multicentre case-control study (ABSCESSBIOT)

Author

Nathalie Costedoat-Chalumeau, Patrick Jégo, Nicolas Barnich, Emilie Vazeille, Maria Nachury, Marc André, Stanislas Faguer, Laurent Sailler, Bruno Pereira, Olivier Chosidow, Alexandre Thibault Jacques Maria, Jean-François Viallard, Arnaud Hot, Jean-David Bouaziz, Jérôme Connault, Jean Schmidt, Ludovic Trefond, Felix Ackermann, Fabrice Bonnet, François Lifermann, Nicolas Limal, Guillaume Cadiot, Elisabeth Billard, Richard Bonnet, Romain Altwegg, Alexandra Audemard-Verger, Damien Richard, Elisabeth Aslangul, Fairouzé Bani Sadr, Sophie Besnard, Jean-François Bourgaux, Sebastien De Almeida, Amandine Dernoncourt, Hélène Desmurs Clavel, Amelie Dutheil, Jean-Marc Galempoix, Camille Hua, Estelle Jean, Wendy Jourde, Clemence Lepelletier, Jean Benoit Monfort, Yves Poinsignon, Marie Laure Rabilloux, Jerome Razatomaery, Clea Rouillon, Mihaela Saplacan, and Laure Swiader

Subjects
Medicine
Abstract

Introduction Aseptic abscess (AA) syndrome is a rare disease whose pathophysiology is unknown. It is often associated with inflammatory bowel disease and characterised by sterile inflammation with collections of neutrophils affecting several organs, especially the spleen. Microbiota are known to influence local and systemic immune responses, and both gut and oral microbiota perturbations have been reported in diseases associated with AA syndrome. However, interactions between these factors have never been studied in AA syndrome. The purpose of this translational case-control study (ABSCESSBIOT) is to investigate gut and/or oral microbiota in patients with AA syndrome compared with healthy controls. Moreover, microbiota associated metabolites quantification and Treg/Th17 balance characterisation will give a mechanistic insight on how microbiota may be involved in the pathophysiology of AA syndrome.Methods and analysis This French multicentre case-control study including 30 French centres (University hospital or regional hospital) aims to prospectively enrol 30 patients with AA syndrome with 30 matched controls and to analyse microbiota profiling (in stools and saliva), microbial metabolites quantification in stools and circulating CD4+ T cell populations.Ethics and dissemination This study protocol was reviewed and approved by an independent French regional review board (n° 2017-A03499-44, Comité de Protection des Personnes Ile de France 1) on 10 October 2022, and declared to the competent French authority (Agence Nationale de Sécurité du Médicament et des produits de santé, France). Oral and written informed consent will be obtained from each included patient and the control participant. Study results will be reported to the scientific community at conferences and in peer-reviewed scientific journals.Trial registration number Clinical Trials web-based platform (NCT05537909).

Published
2023
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15. Human IgG responses to the Aedes albopictus 34k2 salivary protein: analyses in Réunion Island and Bolivia confirm its suitability as marker of host exposure to the tiger mosquito

Author

Sara Buezo Montero, Paolo Gabrieli, Anne Poinsignon, Bi Zamble Hubert Zamble, Fabrizio Lombardo, Franck Remoue, and Bruno Arcà

Subjects
Aedes albopictus, Aedes aegypti, 34k2 salivary protein, Host exposure, Serological marker, Vector control, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The rapid worldwide spreading of Aedes aegypti and Aedes albopictus is expanding the risk of arboviral diseases transmission, pointing out the urgent need to improve monitoring and control of mosquito vector populations. Assessment of human-vector contact, currently estimated by classical entomological methods, is crucial to guide planning and implementation of control measures and evaluate transmission risk. Antibody responses to mosquito genus-specific salivary proteins are emerging as a convenient complementary tool for assessing host exposure to vectors. We previously showed that IgG responses to the Ae. albopictus 34k2 salivary protein (al34k2) allow detection of seasonal and geographic variation of human exposure to the tiger mosquito in two temperate areas of Northeast Italy. The main aim of this study was to confirm and extend these promising findings to tropical areas with ongoing arboviral transmission. Methods IgG responses to al34k2 and to the Ae. aegypti orthologous protein ae34k2 were measured by ELISA in cohorts of subjects only exposed to Ae. albopictus (Réunion Island), only exposed to Ae. aegypti (Bolivia) or unexposed to both these vectors (North of France). Results and conclusion Anti-al34k2 IgG levels were significantly higher in sera of individuals from Réunion Island than in unexposed controls, indicating that al34k2 may be a convenient and reliable proxy for whole saliva or salivary gland extracts as an indicator of human exposure to Ae. albopictus. Bolivian subjects, exposed to bites of Ae. aegypti, carried in their sera IgG recognizing the Ae. albopictus al34k2 protein, suggesting that this salivary antigen can also detect, even though with low sensitivity, human exposure to Ae. aegypti. On the contrary, due to the high background observed in unexposed controls, the recombinant ae34k2 appeared not suitable for the evaluation of human exposure to Aedes mosquitoes. Overall, this study confirmed the suitability of anti-al34k2 IgG responses as a specific biomarker of human exposure to Ae. albopictus and, to a certain extent, to Ae. aegypti. Immunoassays based on al34k2 are expected to be especially effective in areas where Ae. albopictus is the main arboviral vector but may also be useful in areas where Ae. albopictus and Ae. aegypti coexist. Graphical Abstract

Published
2022
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20. Additional insights into the organization of transcriptional regulatory modules based on a 3D model of the Saccharomyces cerevisiae genome

Author

Thibault Poinsignon, Mélina Gallopin, Jean-Michel Camadro, Pierre Poulain, and Gaëlle Lelandais

Subjects
Transcriptional regulations, Chromosome conformation capture, Yeast, 3D-Scere, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Objectives Transcriptional regulatory modules are usually modelled via a network, in which nodes correspond to genes and edges correspond to regulatory associations between them. In the model yeast Saccharomyces cerevisiae, the topological properties of such a network are well-described (distribution of degrees, hierarchical levels, organization in network motifs, etc.). To go further on this, our aim was to search for additional information resulting from the new combination of classical representations of transcriptional regulatory networks with more realistic models of the spatial organization of S. cerevisiae genome in the nucleus. Results Taking advantage of independent studies with high-quality datasets, i.e. lists of target genes for specific transcription factors and chromosome positions in a three dimensional space representing the nucleus, particular spatial co-localizations of genes that shared common regulatory mechanisms were searched. All transcriptional modules of S. cerevisiae, as described in the latest release of the YEASTRACT database were analyzed and significant biases toward co-localization for a few sets of target genes were observed. To help other researchers to reproduce such analysis with any list of genes of their interest, an interactive web tool called 3D-Scere ( https://3d-scere.ijm.fr/ ) is provided.

Published
2022
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21. Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Author

Virginia S. Lioy, Jean-Noël Lorenzi, Soumaya Najah, Thibault Poinsignon, Hervé Leh, Corinne Saulnier, Bertrand Aigle, Sylvie Lautru, Annabelle Thibessard, Olivier Lespinet, Pierre Leblond, Yan Jaszczyszyn, Kevin Gorrichon, Nelle Varoquaux, Ivan Junier, Frédéric Boccard, Jean-Luc Pernodet, and Stéphanie Bury-Moné

Subjects
Science
Abstract

Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al. show that such chromosome structure correlates with genetic compartmentalization, and the onset of metabolic differentiation is accompanied by a rearrangement of chromosome architecture.

Published
2021
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23. Contributions of the Cherenkov Telescope Array (CTA) to the 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma 2016)

Author

Consortium, The CTA, Abchiche, A., Abeysekara, U., Abril, Ó., Acero, F., Acharya, B. S., Adams, C., Agnetta, G., Aharonian, F., Akhperjanian, A., Albert, A., Alcubierre, M., Alfaro, J., Alfaro, R., Allafort, A. J., Aloisio, R., Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonucci, M., Antonuccio, V., Antoranz, P., Aramo, C., Aravantinos, A., Araya, M., Arcaro, C., Arezki, B., Argan, A., Armstrong, T., Arqueros, F., Arrabito, L., Arrieta, M., Asano, K., Ashley, M., Aubert, P., Singh, C. B., Babic, A., Backes, M., Bais, A., Bajtlik, S., Balazs, C., Balbo, M., Balis, D., Balkowski, C., Ballester, O., Ballet, J., Balzer, A., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barcelo, M., Barkov, M., Barnacka, A., de Almeida, U. Barres, Barrio, J. A., Basso, S., Bastieri, D., Bauer, C., Becciani, U., Becherini, Y., Tjus, J. Becker, Beckmann, V., Bednarek, W., Benbow, W., Ventura, D. Benedico, Berdugo, J., Berge, D., Bernardini, E., Bernardini, M. G., Bernhard, S., Bernlöhr, K., Bertucci, B., Besel, M. -A., Beshley, V., Bhatt, N., Bhattacharjee, P., Bhattacharyya, W., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Bilinsky, A., Bilnik, W., Biondo, B., Bird, R., Bird, T., Bissaldi, E., Bitossi, M., Blanch, O., Blasi, P., Blazek, J., Bockermann, C., Boehm, C., Bogacz, L., Bogdan, M., Bohacova, M., Boisson, C., Boix, J., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonifacio, P., Bonnarel, F., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Böttcher, M., Bousquet, J. -J., Boutonnet, C., Bouyjou, F., Bowman, L., Braiding, C., Brantseg, T., Brau-Nogué, S., Bregeon, J., Briggs, M., Brigida, M., Bringmann, T., Brisken, W., Bristow, D., Britto, R., Brocato, E., Bron, S., Brook, P., Brooks, W., Brown, A. M., Brügge, K., Brun, F., Brun, P., Brunetti, G., Brunetti, L., Bruno, P., Buanes, T., Bucciantini, N., Buchholtz, G., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Cadoux, F., Tovar, J. Calvo, Cameron, R., Canelli, F., Canestrari, R., Capalbi, M., Capasso, M., Capobianco, G., Caproni, A., Caraveo, P., Cardenzana, J., Cardillo, M., Carius, S., Carlile, C., Carosi, A., Carosi, R., Carquín, E., Carr, J., Carroll, M., Carter, J., Carton, P. -H., Casandjian, J. -M., Casanova, S., Cascone, E., Casiraghi, M., Castellina, A., Mora, J. Castroviejo, Catalani, F., Catalano, O., Catalanotti, S., Cauz, D., Cavazzani, S., Cerchiara, P., Chabanne, E., Chadwick, P., Chaleil, T., Champion, C., Chatterjee, A., Chaty, S., Chaves, R., Chen, A., Chen, X., Cheng, K., Chernyakova, M., Chiappetti, L., Chikawa, M., Chinn, D., Chitnis, V. R., Cho, N., Christov, A., Chudoba, J., Cieślar, M., Ciocci, M. A., Clay, R., Colafrancesco, S., Colin, P., Colley, J. -M., Colombo, E., Colome, J., Colonges, S., Conforti, V., Connaughton, V., Connell, S., Conrad, J., Contreras, J. L., Coppi, P., Corbel, S., Coridian, J., Cornat, R., Corona, P., Corti, D., Cortina, J., Cossio, L., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Crimi, G., Criswell, S. J., Crocker, R., Croston, J., Cuadra, J., Cumani, P., Cusumano, G., Da Vela, P., Dale, Ø., D'Ammando, F., Dang, D., Dang, V. T., Dangeon, L., Daniel, M., Davids, I., Dawson, B., Dazzi, F., Costa, B. de Aguiar, De Angelis, A., Cardoso, R. F. de Araujo, De Caprio, V., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De Lisio, C., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Decock, G., Decock, J., Deil, C., Del Santo, M., Delagnes, E., Deleglise, G., Delgado, C., Delgado, J., della Volpe, D., Deloye, P., Detournay, M., Dettlaff, A., Devin, J., Di Girolamo, T., Di Giulio, C., Di Paola, A., Di Pierro, F., Diaz, M. A., Díaz, C., Dib, C., Dick, J., Dickinson, H., Diebold, S., Digel, S., Dipold, J., Disset, G., Distefano, A., Djannati-Ataï, A., Doert, M., Dohmke, M., Domínguez, A., Dominik, N., Dominique, J. -L., Prester, D. Dominis, Donat, A., Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Downes, T., Doyle, K., Drake, G., Drappeau, S., Drass, H., Dravins, D., Drury, L., Dubus, G., Ducci, L., Dumas, D., Morå, K. Dundas, Durand, D., D'Urso, D., Dwarkadas, V., Dyks, J., Dyrda, M., Ebr, J., Edy, E., Egberts, K., Eger, P., Egorov, A., Einecke, S., Eisch, J., Eisenkolb, F., Eleftheriadis, C., Elsaesser, D., Elsässer, D., Emmanoulopoulos, D., Engelbrecht, C., Engelhaupt, D., Ernenwein, J. -P., Escarate, P., Eschbach, S., Espinoza, C., Evans, P., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Ramazani, V. Fallah, Fantinel, D., Farakos, K., Farnier, C., Farrell, E., Fasola, G., Favre, Y., Fede, E., Fedora, R., Fedorova, E., Fegan, S., Ferenc, D., Fernandez-Alonso, M., Fernández-Barral, A., Ferrand, G., Ferreira, O., Fesquet, M., Fetfatzis, P., Fiandrini, E., Fiasson, A., Filipčič, A., Filipovic, M., Fink, D., Finley, C., Finley, J. P., Finoguenov, A., Fioretti, V., Fiorini, M., Fleischhack, H., Flores, H., Florin, D., Föhr, C., Fokitis, E., Fonseca, M. V., Font, L., Fontaine, G., Fontes, B., Fornasa, M., Förster, A., Fortin, P., Fortson, L., Fouque, N., Franckowiak, A., Franco, F. J., Albuquerque, I. Freire Mota, Coromina, L. Freixas, Fresnillo, L., Fruck, C., Fuessling, M., Fugazza, D., Fujita, Y., Fukami, S., Fukazawa, Y., Fukuda, T., Fukui, Y., Funk, S., Furniss, A., Gäbele, W., Gabici, S., Gadola, A., Galindo, D., Gall, D. D., Gallant, Y., Galloway, D., Gallozzi, S., Galvez, J. A., Gao, S., Garcia, A., Garcia, B., Gil, R. García, López, R. Garcia, Garczarczyk, M., Gardiol, D., Gargano, C., Gargano, F., Garozzo, S., Garrecht, F., Garrido, L., Garrido-Ruiz, M., Gascon, D., Gaskins, J., Gaudemard, J., Gaug, M., Gaweda, J., Gebhardt, B., Gebyehu, M., Geffroy, N., Genolini, B., Gerard, L., Ghalumyan, A., Ghedina, A., Ghislain, P., Giammaria, P., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Gieras, T., Giglietto, N., Gika, V., Gimenes, R., Giomi, M., Giommi, P., Giordano, F., Giovannini, G., Girardot, P., Giro, E., Giroletti, M., Gironnet, J., Giuliani, A., Glicenstein, J. -F., Gnatyk, R., Godinovic, N., Goldoni, P., Gomez, G., Gonzalez, M. M., González, A., Gora, D., Gothe, K. S., Gotz, D., Goullon, J., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Grasseau, G., Gredig, R., Green, A. J., Green, A. M., Greenshaw, T., Grenier, I., Griffiths, S., Grillo, A., Grondin, M. -H., Grube, J., Grudzinska, M., Grygorczuk, J., Guarino, V., Guberman, D., Gunji, S., Gyuk, G., Hadasch, D., Hagedorn, A., Hagge, L., Hahn, J., Hakobyan, H., Hara, S., Hardcastle, M. J., Hassan, T., Hatanaka, K., Haubold, T., Haupt, A., Hayakawa, T., Hayashida, M., Heller, M., Heller, R., Helo, J. C., Henault, F., Henri, G., Hermann, G., Hermel, R., Llorente, J. Herrera, Herrero, A., Hervet, O., Hidaka, N., Hinton, J., Hirai, W., Hirotani, K., Hnatyk, B., Hoang, J., Hoffmann, D., Hofmann, W., Holch, T., Holder, J., Hooper, S., Horan, D., Hörandel, J., Hörbe, M., Horns, D., Horvath, P., Hose, J., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huet, J. -M., Huetten, M., Hughes, G., Hui, D., Humensky, T. B., Hussein, M., Iacovacci, M., Ibarra, A., Ikeno, Y., Illa, J. M., Impiombato, D., Inada, T., Incorvaia, S., Infante, L., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Iori, M., Ishio, K., Israel, G. L., Iwamura, Y., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janecek, P., Janiak, M., Jankowsky, D., Jankowsky, F., Jean, P., Jegouzo, I., Jenke, P., Jimenez, J. J., Jingo, M., Jocou, L., Jogler, T., Johnson, C. A., Jones, M., Josselin, M., Journet, L., Jung, I., Kaaret, P., Kagaya, M., Kakuwa, J., Kalekin, O., Kalkuhl, C., Kamon, H., Kankanyan, R., Karastergiou, A., Kärcher, K., Karczewski, M., Karkar, S., Karn, P., Kasperek, J., Katagiri, H., Kataoka, J., Katarzyński, K., Kato, S., Katz, U., Kawanaka, N., Kaye, L., Kazanas, D., Kelley-Hoskins, N., Kersten, J., Khélifi, B., Kieda, D. B., Kihm, T., Kimeswenger, S., Kisaka, S., Kishida, S., Kissmann, R., Klepser, S., Kluźniak, W., Knapen, J., Knapp, J., Knödlseder, J., Koch, B., Köck, F., Kocot, J., Kohri, K., Kokkotas, K., Kolitzus, D., Komin, N., Kominis, I., Kong, A., Konno, Y., Kosack, K., Koss, G., Kossatz, M., Kowal, G., Koyama, S., Kozioł, J., Kraus, M., Krause, J., Krause, M., Krawzcynski, H., Krennrich, F., Kretzschmann, A., Kruger, P., Kubo, H., Kudryavtsev, V., Mezek, G. Kukec, Kuklis, M., Kuroda, H., Kushida, J., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Laffon, H., Lahmann, R., Lakicevic, M., Lalik, K., Lamanna, G., Landriu, D., Landt, H., Lang, R. G., Lapington, J., Laporte, P., Fèvre, J. -P. Le, Flour, T. Le, Sidaner, P. Le, Lee, S. -H., Lee, W. H., Lees, J. -P., Lefaucheur, J., Leffhalm, K., Leich, H., de Oliveira, M. A. Leigui, Lelas, D., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leonard, R., Leoni, R., Lessio, L., Leto, G., Leveque, A., Lieunard, B., Limon, M., Lindemann, R., Lindfors, E., Linhoff, L., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Łokas, E., Lombardi, S., Longo, F., Lopatin, A., Lopez, M., Loreggia, D., Louge, T., Louis, F., Louys, M., Lucarelli, F., Lucchesi, D., Lüdecke, H., Luigi, T., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Maccarone, T., Maccarone, T. J., Mach, E., Madejski, G. M., Madonna, A., Magniette, F., Magniez, A., Mahabir, M., Maier, G., Majumdar, P., Makariev, M., Malaguti, G., Malaspina, G., Mallot, A. K., Malouf, A., Maltezos, S., Malyshev, D., Mancilla, A., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Manigot, P., Mankushiyil, N., Mannheim, K., Maragos, N., Marano, D., Marchegiani, P., Marcomini, J. A., Marcowith, A., Mariotti, M., Marisaldi, M., Markoff, S., Martens, C., Martí, J., Martin, J. -M., Martin, L., Martin, P., Martínez, G., Martínez, M., Martínez, O., Martynyuk-Lototskyy, K., Marx, R., Masetti, N., Massimino, P., Mastichiadis, A., Mastroianni, S., Mastropietro, M., Masuda, S., Matsumoto, H., Matsuoka, S., Matthews, N., Mattiazzo, S., Maurin, G., Maxted, N., Maya, J., Mayer, M., Mazin, D., Mazziotta, M. N., Comb, L. Mc, McCubbin, N., McHardy, I., Medina, C., Mehrez, F., Melioli, C., Melkumyan, D., Melse, T., Mereghetti, S., Merk, M., Mertsch, P., Meunier, J. -L., Meures, T., Meyer, M., Meyrelles jr, J. L., Miccichè, A., Michael, T., Michałowski, J., Mientjes, P., Mievre, I., Mihailidis, A., Miller, J., Mineo, T., Minuti, M., Mirabal, N., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mitchell, A., Mizuno, T., Moderski, R., Mognet, I., Mohammed, M., Moharana, R., Mohrmann, L., Molinari, E., Molyneux, P., Monmarthe, E., Monnier, G., Montaruli, T., Monte, C., Monteiro, I., Mooney, D., Moore, P., Moralejo, A., Morello, C., Moretti, E., Mori, K., Morris, P., Morselli, A., Moscato, F., Motohashi, D., Mottez, F., Moudden, Y., Moulin, E., Mueller, S., Mukherjee, R., Munar, P., Munari, M., Mundell, C., Mundet, J., Muraishi, H., Murase, K., Muronga, A., Murphy, A., Nagar, N., Nagataki, S., Nagayoshi, T., Nagesh, B. K., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Nanni, J., Naumann, D., Nayman, P., Nellen, L., Nemmen, R., Neronov, A., Neyroud, N., Nguyen, T., Nguyen, T. T., Trung, T. Nguyen, Nicastro, L., Nicolau-Kukliński, J., Niederwanger, F., Niedźwiecki, A., Niemiec, J., Nieto, D., Nievas-Rosillo, M., Nikolaidis, A., Nikołajuk, M., Nishijima, K., Nishikawa, K. -I., Nishiyama, G., Noda, K., Nogues, L., Nolan, S., Northrop, R., Nosek, D., Nöthe, M., Novosyadlyj, B., Nozka, L., Nunio, F., Oakes, L., O'Brien, P., Ocampo, C., Occhipinti, G., Ochoa, J. P., de Bhroithe, A. OFaolain, Oger, R., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okazaki, N., Okumura, A., Olive, J. -F., Olszowski, D., Ong, R. A., Ono, S., Orienti, M., Orito, R., Orlati, A., Osborne, J., Ostrowski, M., Ottaway, D., Otte, N., Öttl, S., Ovcharov, E., Oya, I., Ozieblo, A., Padovani, M., Pagano, I., Paiano, S., Paizis, A., Palacio, J., Palatka, M., Pallotta, J., Panagiotidis, K., Panazol, J. -L., Paneque, D., Panter, M., Panzera, M. R., Paoletti, R., Paolillo, M., Papayannis, A., Papyan, G., Paravac, A., Paredes, J. M., Pareschi, G., Park, N., Parsons, D., Paśko, P., Pavy, S., Pech, M., Peck, A., Pedaletti, G., Pe'er, A., Peet, S., Pelat, D., Pepato, A., Perez, M. d. C., Perri, L., Perri, M., Persic, M., Petrashyk, A., Petrucci, P. -O., Petruk, O., Peyaud, B., Pfeifer, M., Pfeiffer, G., Piano, G., Pieloth, D., Pierre, E., de Pinho, F. Pinto, García, C. Pio, Piret, Y., Pisarski, A., Pita, S., Platos, Ł., Platzer, R., Podkladkin, S., Pogosyan, L., Pohl, M., Poinsignon, P., Pollo, A., Porcelli, A., Porthault, J., Potter, W., Poulios, S., Poutanen, J., Prandini, E., Prast, J., Pressard, K., Principe, G., Profeti, F., Prokhorov, D., Prokoph, H., Prouza, M., Pruchniewicz, R., Pruteanu, G., Pueschel, E., Pühlhofer, G., Puljak, I., Punch, M., Pürckhauer, S., Pyzioł, R., Queiroz, F., Quel, E. J., Quinn, J., Quirrenbach, A., Rafighi, I., Rainò, S., Rajda, P. J., Rameez, M., Rando, R., Rannot, R. C., Rataj, M., Ravel, T., Razzaque, S., Reardon, P., Reichardt, I., Reimann, O., Reimer, A., Reimer, O., Reisenegger, A., Renaud, M., Renner, S., Reposeur, T., Reville, B., Rezaeian, A., Rhode, W., Ribeiro, D., Prado, R. Ribeiro, Ribó, M., Richards, G., Richer, M. G., Richtler, T., Rico, J., Ridky, J., Rieger, F., Riquelme, M., Ristori, P. R., Rivoire, S., Rizi, V., Roache, E., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rojas, G., Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rose, J., Rosen, S., Lees, S. Rosier, Ross, D., Rouaix, G., Rousselle, J., Rovero, A. C., Rowell, G., Roy, F., Royer, S., Rubini, A., Rudak, B., Rugliancich, A., Rujopakarn, W., Rulten, C., Rupiński, M., Russo, F., Rutkowski, K., Saavedra, O., Sabatini, S., Sacco, B., Sadeh, I., Saemann, E. O., Safi-Harb, S., Saggion, A., Sahakian, V., Saito, T., Sakaki, N., Sakurai, S., Salamon, A., Salega, M., Salek, D., Greus, F. Salesa, Salgado, J., Salina, G., Salinas, L., Salini, A., Sanchez, D., Sanchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Santos-Lima, R., Sanuy, A., Sapozhnikov, L., Sarkar, S., Satalecka, K., Sato, Y., Savalle, R., Sawada, M., Sayède, F., Schanne, S., Schanz, T., Schioppa, E. J., Schlenstedt, S., Schmid, J., Schmidt, T., Schmoll, J., Schneider, M., Schoorlemmer, H., Schovanek, P., Schubert, A., Schullian, E. -M., Schultze, J., Schulz, A., Schulz, S., Schure, K., Schussler, F., Schwab, T., Schwanke, U., Schwarz, J., Schweizer, T., Schwemmer, S., Schwendicke, U., Schwerdt, C., Sciacca, E., Scuderi, S., Segreto, A., Seiradakis, J. -H., Sembroski, G. H., Semikoz, D., Sergijenko, O., Serre, N., Servillat, M., Seweryn, K., Shafi, N., Shalchi, A., Sharma, M., Shayduk, M., Shellard, R. C., Shibata, T., Shigenaka, A., Shilon, I., Shum, E., Sidoli, L., Sidz, M., Sieiro, J., Siejkowski, H., Silk, J., Sillanpää, A., Simone, D., Simpson, H., Singh, B. B., Sinha, A., Sironi, G., Sitarek, J., Sizun, P., Sliusar, V., Smith, A., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spengler, G., Spiga, R., Stadler, R., Stahl, O., Stamerra, A., Stanič, S., Starling, R., Staszak, D., Stawarz, Ł., Steenkamp, R., Stefanik, S., Stegmann, C., Steiner, S., Stella, C., Stephan, M., Stergioulas, N., Sternberger, R., Sterzel, M., Stevenson, B., Stinzing, F., Stodulska, M., Stodulski, M., Stolarczyk, T., Stratta, G., Straumann, U., Stringhetti, L., Strzys, M., Stuik, R., Sulanke, K. -H., Suomijärvi, T., Supanitsky, A. D., Suric, T., Sushch, I., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Szwarnog, P., Tacchini, A., Tachihara, K., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takahashi, M., Takalo, L., Takami, S., Takata, J., Takeda, J., Talbot, G., Tam, T., Tanaka, M., Tanaka, S., Tanaka, T., Tanaka, Y., Tanci, C., Tanigawa, S., Tavani, M., Tavecchio, F., Tavernet, J. -P., Tayabaly, K., Taylor, A., Tejedor, L. A., Telezhinsky, I., Temme, F., Temnikov, P., Tenzer, C., Terada, Y., Terrazas, J. C., Terrier, R., Terront, D., Terzic, T., Tescaro, D., Teshima, M., Testa, V., Tezier, D., Thayer, J., Thornhill, J., Thoudam, S., Thuermann, D., Tibaldo, L., Tiengo, A., Timpanaro, M. C., Tiziani, D., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tokarz, M., Toma, K., Tomastik, J., Tomono, Y., Tonachini, A., Tonev, D., Torii, K., Tornikoski, M., Torres, D. F., Torres, M., Torresi, E., Toso, G., Tosti, G., Totani, T., Tothill, N., Toussenel, F., Tovmassian, G., Toyama, T., Travnicek, P., Trichard, C., Trifoglio, M., Pujadas, I. Troyano, Trzeciak, M., Tsinganos, K., Tsujimoto, S., Tsuru, T., Uchiyama, Y., Umana, G., Umetsu, Y., Upadhya, S. S., Uslenghi, M., Vagelli, V., Vagnetti, F., Valdes-Galicia, J., Valentino, M., Vallania, P., Valore, L., van Driel, W., van Eldik, C., van Soelen, B., Vandenbroucke, J., Vanderwalt, J., Vasileiadis, G., Vassiliev, V., Vázquez, J. R., Acosta, M. L. Vázquez, Vecchi, M., Vega, A., Vegas, I., Veitch, P., Venault, P., Venema, L., Venter, C., Vercellone, S., Vergani, S., Verma, K., Verzi, V., Vettolani, G. P., Veyssiere, C., Viana, A., Viaux, N., Vicha, J., Vigorito, C., Vincent, P., Vincent, S., Vink, J., Vittorini, V., Vlahakis, N., Vlahos, L., Voelk, H., Voisin, V., Vollhardt, A., Volpicelli, A., von Brand, H., Vorobiov, S., Vovk, I., Vrastil, M., Vu, L. V., Vuillaume, T., Wagner, R., Wagner, S. J., Wakely, S. P., Walstra, T., Walter, R., Walther, T., Ward, J. E., Ward, M., Warda, K., Warren, D., Wassberg, S., Watson, J. J., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weiner, O., Weinstein, A., Wells, R., Werner, F., Wetteskind, H., White, M., White, R., Więcek, M., Wierzcholska, A., Wiesand, S., Wijers, R., Wilcox, P., Wild, N., Wilhelm, A., Wilkinson, M., Will, M., Williams, D. A., Williams, J. T., Willingale, R., Wilson, N., Winde, M., Winiarski, K., Winkler, H., Winter, M., Wischnewski, R., Witt, E., Wojcik, P., Wolf, D., Wood, M., Wörnlein, A., Wu, E., Wu, T., Yadav, K. K., Yamamoto, H., Yamamoto, T., Yamane, N., Yamazaki, R., Yanagita, S., Yang, L., Yelos, D., Yoshida, A., Yoshida, M., Yoshida, T., Yoshiike, S., Yoshikoshi, T., Yu, P., Zabalza, V., Zaborov, D., Zacharias, M., Zaharijas, G., Zajczyk, A., Zampieri, L., Zandanel, F., Sanchez, R. Zanmar, Zaric, D., Zavrtanik, D., Zavrtanik, M., Zdziarski, A., Zech, A., Zechlin, H., Zhao, A., Zhdanov, V., Ziegler, A., Ziemann, J., Ziętara, K., Zink, A., Ziółkowski, J., Zitelli, V., Zoli, A., Zorn, J., and Żychowski, P.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

List of contributions from the Cherenkov Telescope Array (CTA) Consortium presented at the 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma 2016), July 11-15, 2016, in Heidelberg, Germany., Comment: Index of CTA conference proceedings for the Gamma 2016, Heidelberg, Germany

Published
2016

24. Cross-sectional study of the prevalence of prescription opioids misuse in French patients with chronic non-cancer pain: An update with the French version of the POMI scale

Author

Nicolas Kerckhove, Noémie Delage, Célian Bertin, Emmanuelle Kuhn, Nathalie Cantagrel, Caroline Vigneau, Jessica Delorme, Céline Lambert, Bruno Pereira, Chouki Chenaf, Nicolas Authier, Poma Network, Debbah Abdelouahab, Peyre Alexandre, Simon Anna, Defeuillet Catherine, Wiart Catherine, Sureau Christophe, Vulser Cristofini Claire, Bouhassira Didier, Touchard Emmanuelle, Collin Elisabeth, Serra Eric, Perez-Varlan Evelyne, Mohy Frédérique, Peyriere Hélène, Le Borgne Jean-Marie, Poinsignon Jean Paul, Micallef Joëlle, Dy Lénaïg, Amilhaud Marlène, Venard Maria, Dorsner-Binard Marie, Berrier Oui Marie, Martial Maud, Feuillet Maryline, De Rijk Pablo, Ginies Patrick, Kieffert Patrick, Giraud Pierric, Aerts Raluca, Le Boisselier Reynald, Cauchin Sonia, Pouplin Sophie, Corand Virginie, Perier Yannick, and Poujol Yves

Subjects
opioids, prevalence, chronic non-cancer pain, POMI scale, prescription drug misuse, Therapeutics. Pharmacology, RM1-950
Abstract

Public health issues related to chronic pain management and the risks of opioid misuse and abuse remain a challenge for practitioners. Data on the prevalence of disorders related to the use of prescribed opioids in patients suffering from chronic pain remains rather patchy, in particular because of the absence of a gold standard for their clinical assessment. We estimated the prevalence of prescription opioid misuse (POM), using a specific and validated opioid misuse scale (POMI-5F scale), in adults with chronic non-cancer pain. Nine-hundred-fifty-one (951) patients with opioids prescription and followed-up in pain clinics and addictology centers for chronic non-cancer pain (CNCP) completed the survey interview. The results suggest that 44.4% of participants have POM, accompanied by overuse (42.5%), use of opioids for effects other than analgesia (30.9%), withdrawal syndrome (65.7%), and craving (6.9%). The motivations cited for POM, apart from pain relief, were to calm down, relax and improve mood. POM was shown to be related to male sex (OR 1.52), young age (OR 2.21) and the presence of nociplastic pain (OR 1.62) of severe intensity (OR 2.31), codeine use (OR 1.72) and co-prescription of benzodiazepines (OR 1.59). Finally, despite the presence of three subgroups of misusers, no factor was associated with the intensity of misuse, reinforcing the view that distinguishing between strong and weak opioids is not appropriate in the context of use disorder. Almost half of patients with CNCP misuse their prescribed opioid. Practitioners should be attentive of profiles of patients at risk of POM, such as young, male patients suffering from severe nociplastic pain, receiving prescription for codeine and a co-prescription for benzodiazepine. We encourage French-speaking practitioners to use the POMI-5F scale to assess the presence of POM in their patients receiving opioid-based therapy.Clinical Trial Registrationclinicaltrials.gov, identifier NCT03195374

Published
2022
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25. Gelatin Methacryloyl (GelMA) Hydrogel Scaffolds: Predicting Physical Properties Using an Experimental Design Approach

Author

Corentin Peyret, Kamil Elkhoury, Sabine Bouguet-Bonnet, Sophie Poinsignon, Corentin Boulogne, Tristan Giraud, Loïc Stefan, Yasmina Tahri, Laura Sanchez-Gonzalez, Michel Linder, Ali Tamayol, Cyril J.F. Kahn, and Elmira Arab-Tehrany

Subjects
gelatin methacryloyl, experimental design, multiscale characterisation, NMR, rheology, compression, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

There is a growing interest for complex in vitro environments that closely mimic the extracellular matrix and allow cells to grow in microenvironments that are closer to the one in vivo. Protein-based matrices and especially hydrogels can answer this need, thanks to their similarity with the cell microenvironment and their ease of customization. In this study, an experimental design was conducted to study the influence of synthesis parameters on the physical properties of gelatin methacryloyl (GelMA). Temperature, ratio of methacrylic anhydride over gelatin, rate of addition, and stirring speed of the reaction were studied using a Doehlert matrix. Their impact on the following parameters was analyzed: degree of substitution, mass swelling ratio, storage modulus (log(G’)), and compression modulus. This study highlights that the most impactful parameter was the ratio of methacrylic anhydride over gelatin. Although, temperature affected the degree of substitution, and methacrylic anhydride addition flow rate impacted the gel’s physical properties, namely, its storage modulus and compression modulus. Moreover, this experimental design proposed a theoretical model that described the variation of GelMA’s physical characteristics as a function of synthesis conditions.

Published
2023
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26. Performance of automated methods for flash flood inundation mapping: a comparison of a digital terrain model (DTM) filling and two hydrodynamic methods

Author

N. Hocini, O. Payrastre, F. Bourgin, E. Gaume, P. Davy, D. Lague, L. Poinsignon, and F. Pons

Subjects
Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

Flash floods observed in headwater catchments often cause catastrophic material and human damage worldwide. Considering the large number of small watercourses possibly affected, the use of automated methods for flood inundation mapping at a regional scale can be of great help for the identification of threatened areas and the prediction of potential impacts of these floods. An application of three mapping methods of increasing level of complexity is presented herein, including a digital terrain model (DTM) filling approach (height above nearest drainage/Manning–Strickler or HAND/MS) and two hydrodynamic methods (caRtino 1D and Floodos 2D). These methods are used to estimate the flooded areas of three major flash floods observed during the last 10 years in southeastern France, i.e., the 15 June 2010 flooding of the Argens river and its tributaries (585 km of river reaches), the 3 October 2015 flooding of small coastal rivers of the French Riviera (131 km of river reaches) and the 15 October 2018 flooding of the Aude river and its tributaries (561 km of river reaches). The common features of the three mapping approaches are their high level of automation, their application based on a high-resolution (5 m) DTM, and their reasonable computation times. Hydraulic simulations are run in steady-state regime, based on peak discharges estimated using a rainfall–runoff model preliminarily adjusted for each event. The simulation results are compared with the reported flood extent maps and the high water level marks. A clear grading of the tested methods is revealed, illustrating some limits of the HAND/MS approach and an overall better performance of hydraulic models which solve the shallow water equations. With these methods, a good retrieval of the inundated areas is illustrated by critical success index (CSI) median values close to 80 %, and the errors on water levels remain mostly below 80 cm for the 2D Floodos approach. The most important remaining errors are related to limits of the DTM, such as the lack of bathymetric information, uncertainties on embankment elevation, and possible bridge blockages not accounted for in the models.

Published
2021
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27. Use of an Anopheles Salivary Biomarker to Assess Malaria Transmission Risk Along the Thailand-Myanmar Border.

Author

Ya-Umphan, Phubeth, Cerqueira, Dominique, Parker, Daniel M, Cottrell, Gilles, Poinsignon, Anne, Remoue, Franck, Brengues, Cecile, Chareonviriyaphap, Theeraphap, Nosten, Francois, and Corbel, Vincent

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Research, Malaria, Infectious Diseases, Rare Diseases, Vector-Borne Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Adolescent, Adult, Aged, Animals, Anopheles, Biomarkers, Child, Child, Preschool, Cohort Studies, Environmental Exposure, Female, Humans, Immunoglobulin G, Infant, Infant, Newborn, Insect Bites and Stings, Insect Proteins, Male, Middle Aged, Myanmar, Salivary Proteins and Peptides, Thailand, Young Adult, Thailand-Myanmar border, malaria vectors, transmission, human antibody response, Salivary Biomarker, gSG6-P1, gSG6-P1., Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe modalities of malaria transmission along the Thailand-Myanmar border are poorly understood. Here we address the relevance of using a specific Anopheles salivary biomarker to measure the risk among humans of exposure to Anopheles bites.MethodsSerologic surveys were conducted from May 2013 to December 2014 in 4 sentinel villages. More than 9400 blood specimens were collected in filter papers from all inhabitants at baseline and then every 3 months thereafter, for up to 18 months, for analysis by enzyme-linked immunosorbent assay. The relationship between the intensity of the human antibody response and entomological indicators of transmission (human biting rates and entomological inoculation rates [EIRs]) was studied using a multivariate 3-level mixed model analysis. Heat maps for human immunoglobulin G (IgG) responses for each village and survey time point were created using QGIS 2.4.ResultsThe levels of IgG response among participants varied significantly according to village, season, and age (P

Published
2017

28. CTA Contributions to the 34th International Cosmic Ray Conference (ICRC2015)

Author

Consortium, The CTA, Abchiche, A., Abeysekara, U., Abril, Ó., Acero, F., Acharya, B. S., Actis, M., Agnetta, G., Aguilar, J. A., Aharonian, F., Akhperjanian, A., Albert, A., Alcubierre, M., Alfaro, R., Aliu, E., Allafort, A. J., Allan, D., Allekotte, I., Aloisio, R., Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonucci, M., Antonuccio, V., Antoranz, P., Aramo, C., Aravantinos, A., Argan, A., Armstrong, T., Arnaldi, H., Arnold, L., Arrabito, L., Arrieta, M., Asano, K., Asorey, H. G., Aune, T., Singh, C. B., Babic, A., Backes, M., Bais, A., Bajtlik, S., Balazs, C., Balbo, M., Balis, D., Balkowski, C., Ballester, O., Ballet, J., Balzer, A., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barceló, M., Barnacka, A., de Almeida, U. Barres, Barrio, J. A., Basso, S., Bastieri, D., Bauer, C., Baushev, A., Becciani, U., Becherini, Y., Tjus, J. Becker, Beckmann, V., Bednarek, W., Benbow, W., Ventura, D. Benedico, Berdugo, J., Berge, D., Bernardini, E., Bernhard, S., Bernlöhr, K., Bertucci, B., Besel, M. -A., Bhatt, N., Bhattacharjee, P., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Billotta, S., Bilnik, W., Biondo, B., Bird, T., Birsin, E., Bissaldi, E., Biteau, J., Bitossi, M., Bigas, O. Blanch, Blasi, P., Boehm, C., Bogacz, L., Bogdan, M., Bohacova, M., Boisson, C., Gargallo, J. Boix, Bolmont, J., Bonanno, G., Bonardi, A., Bonifacio, P., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Bottani, A., Böttcher, M., Bousquet, J. -J., Boutonnet, C., Bouyjou, F., Braiding, C., Brandt, L., Brau-Nogué, S., Bregeon, J., Bretz, T., Briggs, M., Brigida, M., Bringmann, T., Brisken, W., Brocato, E., Brook, P., Brown, A. M., Brun, P., Brunetti, G., Brunetti, L., Bruno, P., Bryan, M., Buanes, T., Bucciantini, N., Buchholtz, G., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Cameron, R., Camprecios, J., Canelli, F., Canestrari, R., Cantu, S., Capalbi, M., Capasso, M., Capobianco, G., Caraveo, P., Cardenzana, J., Carius, S., Carlile, C., Carmona, E., Carosi, A., Carosi, R., Carr, J., Carroll, M., Carter, J., Carton, P. -H., Caruso, R., Casandjian, J. -M., Casanova, S., Cascone, E., Casiraghi, M., Castellina, A., Catalano, O., Catalanotti, S., Cavazzani, S., Cazaux, S., Cefalà, M., Cerchiara, P., Cereda, M., Cerruti, M., Chabanne, E., Chadwick, P., Champion, C., Chaty, S., Chaves, R., Cheimets, P., Chen, A., Chen, X., Chernyakova, M., Chiappetti, L., Chikawa, M., Chinn, D., Chitnis, V. R., Cho, N., Christov, A., Chudoba, J., Cieślar, M., Cillis, A., Ciocci, M. A., Clay, R., Cohen-Tanugi, J., Colafrancesco, S., Colin, P., Colombo, E., Colome, J., Colonges, S., Compin, M., Conforti, V., Connaughton, V., Connell, S., Conrad, J., Contreras, J. L., Coppi, P., Corbel, S., Coridian, J., Corona, P., Corti, D., Cortina, J., Cossio, L., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Crimi, G., Criswell, S. J., Crocker, R., Croston, J., Cusumano, G., Da Vela, P., Dale, Ø., D'Ammando, F., Dang, D., Daniel, M., Davids, I., Dawson, B., Dazzi, F., Costa, B. de Aguiar, De Angelis, A., Cardoso, R. F. de Araujo, De Caprio, V., De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De La Vega, G. A., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Decock, G., Deil, C., Del Santo, M., Delagnes, E., Deleglise, G., Delgado, C., della Volpe, D., Deloye, P., Depaola, G., Detournay, M., Dettlaff, A., Di Girolamo, T., Di Giulio, C., Di Paola, A., Di Pierro, F., Di Sciascio, G., Díaz, C., Dick, J., Dickinson, H., Diebold, S., Diez, V., Digel, S., Dipold, J., Disset, G., Distefano, A., Djannati-Ataï, A., Doert, M., Dohmke, M., Domainko, W., Dominik, N., Prester, D. Dominis, Donat, A., Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Doyle, K., Drake, G., Dravins, D., Drury, L., Dubus, G., Dumas, D., Dumm, J., Durand, D., D'Urso, D., Dwarkadas, V., Dyks, J., Dyrda, M., Ebr, J., Echaniz, J. C., Edy, E., Egberts, K., Eger, P., Einecke, S., Eisch, J., Eisenkolb, F., Eleftheriadis, C., Elsässer, D., Emmanoulopoulos, D., Engelbrecht, C., Engelhaupt, D., Ernenwein, J. -P., Errando, M., Eschbach, S., Etchegoyen, A., Evans, P., Fairbairn, M., Falcone, A., Fantinel, D., Farakos, K., Farnier, C., Farrell, E., Farrell, S., Fasola, G., Fegan, S., Feinstein, F., Ferenc, D., Fernandez, A., Fernandez-Alonso, M., Ferreira, O., Fesquet, M., Fetfatzis, P., Fiasson, A., Filipčič, A., Filipovic, M., Fink, D., Finley, C., Finley, J. P., Finoguenov, A., Fioretti, V., Fiorini, M., Curcoll, R. Firpo, Fleischhack, H., Flores, H., Florin, D., Föhr, C., Fokitis, E., Font, L., Fontaine, G., Fontes, B., Forest, F., Fornasa, M., Förster, A., Fortin, P., Fortson, L., Fouque, N., Franckowiak, A., Franco, F. J., Frankowski, A., Frega, N., Albuquerque, I. Freire Mota, Coromina, L. Freixas, Fresnillo, L., Fruck, C., Fuessling, M., Fugazza, D., Fujita, Y., Fukami, S., Fukazawa, Y., Fukuda, T., Fukui, Y., Funk, S., Gäbele, W., Gabici, S., Gadola, A., Galante, N., Gall, D. D., Gallant, Y., Galloway, D., Gallozzi, S., Gao, S., Garcia, B., Gil, R. García, López, R. Garcia, Garczarczyk, M., Gardiol, D., Gargano, C., Gargano, F., Garozzo, S., Garrecht, F., Garrido, D., Garrido, L., Gascon, D., Gaskins, J., Gaudemard, J., Gaug, M., Gaweda, J., Geffroy, N., Gérard, L., Ghalumyan, A., Ghedina, A., Ghigo, M., Ghislain, P., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Giglietto, N., Gika, V., Gimenes, R., Giomi, M., Giommi, P., Giordano, F., Giovannini, G., Giro, E., Giroletti, M., Giuliani, A., Glicenstein, J. -F., Godinovic, N., Goldoni, P., Berisso, M. Gomez, Vargas, G. A. Gomez, Gonzalez, M. M., González, A., González, F., Muñoz, A. González, Gothe, K. S., Gotz, D., Grabarczyk, T., Graciani, R., Grandi, P., Grañena, F., Granot, J., Grasseau, G., Gredig, R., Green, A. J., Green, A. M., Greenshaw, T., Grenier, I., Grillo, A., Grondin, M. -H., Grube, J., Grudzinska, M., Grygorczuk, J., Guarino, V., Guberman, D., Gunji, S., Gyuk, G., Hadasch, D., Hagedorn, A., Hahn, J., Hakansson, N., Heras, N. Hamer, Hanabata, Y., Hara, S., Hardcastle, M. J., Harris, J., Hassan, T., Hatanaka, K., Haubold, T., Haupt, A., Hayakawa, T., Hayashida, M., Heller, M., Heller, R., Henault, F., Henri, G., Hermann, G., Hermel, R., Llorente, J. Herrera, Herrero, A., Hervet, O., Hidaka, N., Hinton, J., Hirai, W., Hirotani, K., Hoard, D., Hoffmann, D., Hofmann, W., Hofverberg, P., Holch, T., Holder, J., Hooper, S., Horan, D., Hörandel, J. R., Hormigos, S., Horns, D., Hose, J., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huet, J. -M., Hütten, M., Humensky, T. B., Huovelin, J., Huppert, J. -F., Iacovacci, M., Ibarra, A., Idźkowski, B., Ikawa, D., Illa, J. M., Impiombato, D., Incorvaia, S., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Iori, M., Ishio, K., Israel, G. L., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janecek, P., Janiak, M., Jankowsky, F., Jean, P., Jeanney, C., Jegouzo, I., Jenke, P., Jimenez, J. J., Jingo, M., Jocou, L., Jogler, T., Johnson, C. A., Journet, L., Juffroy, C., Jung, I., Kaaret, P. E., Kagaya, M., Kakuwa, J., Kalekin, O., Kalkuhl, C., Kankanyan, R., Karastergiou, A., Kärcher, K., Karczewski, M., Karkar, S., Karn, P., Kasperek, J., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kaufmann, S., Kawanaka, N., Kawashima, T., Kazanas, D., Kelley-Hoskins, N., Kellner-Leidel, B., Kendziorra, E., Kersten, J., Khélifi, B., Kieda, D. B., Kihm, T., Kisaka, S., Kissmann, R., Klepser, S., Kluźniak, W., Knapen, J., Knapp, J., Knödlseder, J., Köck, F., Kocot, J., Kodakkadan, A., Kodani, K., Kohri, K., Kojima, T., Kokkotas, K., Kolitzus, D., Komin, N., Kominis, I., Konno, Y., Kosack, K., Koss, G., Koul, R., Kowal, G., Koyama, S., Kozioł, J., Kraus, M., Krause, J., Krause, M., Krawzcynski, H., Krennrich, F., Kretzschmann, A., Kruger, P., Kubo, H., Kudryavtsev, V., Mezek, G. Kukec, Kushida, J., Kuznetsov, A., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Laffon, H., Lagadec, T., Lahmann, R., Lalik, K., Lamanna, G., Landriu, D., Landt, H., Lang, R. G., Languignon, D., Lapington, J., Laporte, P., Latovski, N., Law-Green, D., Fèvre, J. -P. Le, Flour, T. Le, Sidaner, P. Le, Lee, S. -H., Lee, W. H., Leffhalm, K., Leich, H., de Oliveira, M. A. Leigui, Lelas, D., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leonard, R., Leoni, R., Lessio, L., Leto, G., Leveque, A., Lieunard, B., Limon, M., Lindemann, R., Lindfors, E., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Loiseau, D., Łokas, E., Lombardi, S., Longo, F., Longo, G., Lopatin, A., Lopez, M., López-Coto, R., López-Oramas, A., Loreggia, D., Louge, T., Louis, F., Lu, C. -C., Lucarelli, F., Lucchesi, D., Lüdecke, H., Luque-Escamilla, P. L., Luz, O., Lyard, E., Maccarone, M. C., Maccarone, T. J., Mach, E., Madejski, G. M., Madonna, A., Mahabir, M., Maier, G., Majumdar, P., Makariev, M., Malaguti, G., Malaspina, G., Mallot, A. K., Maltezos, S., Mancilla, A., Mandat, D., Maneva, G., Manigot, P., Mankushiyil, N., Mannheim, K., Maragos, N., Marano, D., Marchegiani, P., Marcomini, J. A., Marcowith, A., Mariotti, M., Marisaldi, M., Markoff, S., Marszałek, A., Martens, C., Martí, J., Martin, J. -M., Martin, P., Martínez, G., Martínez, M., Martínez, O., Marx, R., Massimino, P., Mastichiadis, A., Mastroianni, S., Mastropietro, M., Masuda, S., Matsumoto, H., Matsuoka, S., Mattiazzo, S., Maurin, G., Maxted, N., Maya, J., Mayer, M., Mazin, D., Mazureau, E., Mazziotta, M. N., Comb, L. Mc, McCann, A., McCubbin, N., McHardy, I., McKay, R., McKinney, K., Meagher, K., Medina, C., Mehrez, F., Melioli, C., Melkumyan, D., Melo, D., Melse, T., Mereghetti, S., Mertsch, P., Meyer, M., Meyrelles jr, J. L., Miccichè, A., Michałowski, J., Micolon, P., Mientjes, P., Mignot, S., Mihailidis, A., Mineo, T., Minuti, M., Mirabal, N., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mistò, A., Mitchell, A., Mizuno, T., Moderski, R., Mognet, I., Mohammed, M., Moharana, R., Molinari, E., Monmarthe, E., Monnier, G., Montaruli, T., Monte, C., Monteiro, I., Moore, P., Olaizola, A. Moralejo, Morello, C., Moretti, E., Mori, K., Morlino, G., Morselli, A., Mottez, F., Moudden, Y., Moulin, E., Mrusek, I., Mueller, S., Mukherjee, R., Munar-Adrover, P., Mundell, C., Muraishi, H., Murase, K., Muronga, A., Murphy, A., Nagataki, S., Nagayoshi, T., Nagesh, B. K., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Naumann, D., Nayman, P., Nellen, L., Nemmen, R., Neronov, A., Neustroev, V., Neyroud, N., Nguyen, T., Nicastro, L., Nicolau-Kukliński, J., Niederwanger, F., Niedźwiecki, A., Niemiec, J., Nieto, D., Nievas, M., Nikolaidis, A., Nishijima, K., Nishikawa, K. -I., Noda, K., Nogues, L., Nolan, S., Northrop, R., Nosek, D., Nozka, L., Nunio, F., Oakes, L., O'Brien, P., Occhipinti, G., de Bhroithe, A. O'Faolain, Ogino, M., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okumura, A., Olive, J. -F., Olszowski, D., Ong, R. A., Ono, S., Orienti, M., Orito, R., Orlati, A., Osborne, J., Ostrowski, M., Otero, L. A., Ottaway, D., Otte, N., Oya, I., Ozieblo, A., Padovani, M., Pagano, I., Paiano, S., Paizis, A., Palacio, J., Palatka, M., Pallotta, J., Panagiotidis, K., Panazol, J. -L., Paneque, D., Panter, M., Panzera, M. R., Paoletti, R., Paolillo, M., Papayannis, A., Papyan, G., Paravac, A., Paredes, J. M., Pareschi, G., Park, N., Parsons, D., Paśko, P., Pavy, S., Arribas, M. Paz, Pech, M., Peck, A., Pedaletti, G., Peet, S., Pelassa, V., Pelat, D., Peres, C., Perez, M. d. C., Perri, L., Persic, M., Petrashyk, A., Petrucci, P. -O., Peyaud, B., Pfeifer, M., Pfeiffer, G., Piano, G., Pichel, A., Pieloth, D., Pierbattista, M., Pierre, E., de Pinho, F. Pinto, García, C. Pio, Piret, Y., Pita, S., Planes, A., Platino, M., Platos, Ł., Platzer, R., Podkladkin, S., Pogosyan, L., Pohl, M., Poinsignon, P., Ponz, J. D., Porcelli, A., Potter, W., Poulios, S., Poutanen, J., Prandini, E., Prast, J., Preece, R., Profeti, F., Prokhorov, D., Prokoph, H., Prouza, M., Proyetti, M., Pruchniewicz, R., Pueschel, E., Pühlhofer, G., Puljak, I., Punch, M., Pyzioł, R., Queiroz, F., Quel, E. J., Quinn, J., Quirrenbach, A., Racero, E., Räck, T., Rafalski, J., Rafighi, I., Rainò, S., Rajda, P. J., Rameez, M., Rando, R., Rannot, R. C., Rataj, M., Rateau, S., Ravel, T., Ravignani, D., Razzaque, S., Reardon, P., Reimann, O., Reimer, A., Reimer, O., Reitberger, K., Renaud, M., Renner, S., Reposeur, T., Rettig, R., Reville, B., Rhode, W., Ribeiro, D., Ribó, M., Richards, G., Richer, M. G., Rico, J., Ridky, J., Rieger, F., Ringegni, P., Ristori, P. R., Rivière, A., Rivoire, S., Roache, E., Rodeghiero, G., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rogers, T., Rojas, G., Romano, P., Rodriguez, M. P. Romay, Romeo, G., Romero, G. E., Roncadelli, M., Rose, J., Rosen, S., Lees, S. Rosier, Ross, D., Rossiter, P., Rouaix, G., Rousselle, J., Rovero, A. C., Rowell, G., Roy, F., Royer, S., Różańska, A., Rudak, B., Rugliancich, A., Rulten, C., Rupiński, M., Russo, F., Rutkowski, K., Saavedra, O., Sabatini, S., Sacco, B., Saemann, E. O., Saggion, A., Saha, L., Sahakian, V., Saito, K., Saito, T., Sakaki, N., Salega, M., Salek, D., Salgado, J., Salini, A., Sanchez, D., Sanchez, F., Sanchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Santos-Lima, R., Sanuy, A., Sapozhnikov, L., Sarkar, S., Satalecka, K., Savalle, R., Sawada, M., Sayède, F., Schafer, J., Schanne, S., Schanz, T., Schioppa, E. J., Schlenstedt, S., Schlickeiser, R., Schmidt, T., Schmoll, J., Schneider, M., Schovanek, P., Schubert, A., Schultz, C., Schultze, J., Schulz, A., Schulz, S., Schure, K., Schussler, F., Schwab, T., Schwanke, U., Schwarz, J., Schweizer, T., Schwemmer, S., Schwendicke, U., Schwerdt, C., Segreto, A., Seiradakis, J. -H., Sembroski, G. H., Semikoz, D., Serre, N., Servillat, M., Seweryn, K., Shafi, N., Sharma, M., Shayduk, M., Shellard, R. C., Shibata, T., Pandeni, K. Shiningayamwe, Shukla, A., Shum, E., Sidoli, L., Sidz, M., Sieiro, J., Siejkowski, H., Silk, J., Sillanpää, A., Simone, D., Singh, B. B., Sinha, A., Sironi, G., Sitarek, J., Sizun, P., Slyusar, V., Smith, A., Smith, J., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spengler, G., Spiga, D., Stadler, R., Stahl, O., Stamatescu, V., Stamerra, A., Stanič, S., Starling, R., Stawarz, Ł., Steenkamp, R., Stefanik, S., Stegmann, C., Steiner, S., Stella, C., Stergioulas, N., Sternberger, R., Sterzel, M., Stevenson, B., Stinzing, F., Stodulska, M., Stodulski, M., Stolarczyk, T., Straumann, U., Strazzeri, E., Stringhetti, L., Strzys, M., Stuik, R., Sulanke, K. -H., Supanitsky, A. D., Suric, T., Sushch, I., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Szwarnog, P., Tacchini, A., Tachihara, K., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takahashi, M., Takalo, L., Takami, H., Talbot, G., Tammi, J., Tanaka, M., Tanaka, S., Tanaka, T., Tanaka, Y., Tanci, C., Tarantino, E., Tavani, M., Tavecchio, F., Tavernet, J. -P., Tayabaly, K., Tejedor, L. A., Telezhinsky, I., Temme, F., Temnikov, P., Tenzer, C., Terada, Y., Terrier, R., Tescaro, D., Teshima, M., Testa, V., Tezier, D., Thayer, J., Thomas, V., Thornhill, J., Thuermann, D., Tibaldo, L., Tibolla, O., Tiengo, A., Tijsseling, G., Timpanaro, M. C., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tokarz, M., Toma, K., Tomastik, J., Tomono, Y., Tonachini, A., Tonev, D., Torii, K., Tornikoski, M., Torres, D. F., Torres, M., Torresi, E., Toscano, S., Toso, G., Tosti, G., Totani, T., Tothill, N., Toussenel, F., Tovmassian, G., Townsley, C., Toyama, T., Travnicek, P., Trifoglio, M., Pujadas, I. Troyano, Trzeciak, M., Tsinganos, K., Tsubone, Y., Tsuchiya, Y., Tsujimoto, S., Tsuru, T., Uchiyama, Y., Umana, G., Umetsu, Y., Underwood, C., Upadhya, S. S., Uslenghi, M., Vagnetti, F., Valdes-Galicia, J., Vallania, P., Vallejo, G., Valore, L., van Driel, W., van Eldik, C., van Soelen, B., Vandenbroucke, J., Vanderwalt, J., Vasileiadis, G., Vassiliev, V., Acosta, M. L. Vázquez, Vecchi, M., Vegas, I., Veitch, P., Venema, L., Venter, C., Vercellone, S., Vergani, S., Verma, K., Verzi, V., Vettolani, G. P., Viana, A., Vicha, J., Videla, M., Vigorito, C., Vincent, P., Vincent, S., Vink, J., Vittorini, V., Vlahakis, N., Vlahos, L., Voelk, H., Vogler, P., Voisin, V., Vollhardt, A., Volpicelli, A., Vorobiov, S., Vovk, I., Vu, L. V., Wagner, R., Wagner, R. M., Wagner, R. G., Wagner, S. J., Wakely, S. P., Walter, R., Walther, T., Ward, J. E., Ward, M., Warda, K., Warwick, R., Wassberg, S., Watson, J., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weinstein, A., Weitzel, Q., Wells, R., Werner, F., Werner, M., Wetteskind, H., White, M., White, R., Więcek, M., Wierzcholska, A., Wiesand, S., Wijers, R., Wild, N., Wilhelm, A., Wilkinson, M., Will, M., Williams, D. A., Williams, J. T., Willingale, R., Winde, M., Winiarski, K., Winkler, H., Wischnewski, R., Wojcik, P., Wolf, D., Wood, M., Wörnlein, A., Wu, E., Wu, T., Yadav, K. K., Yamamoto, H., Yamamoto, T., Yamazaki, R., Yanagita, S., Yang, L., Yebras, J. M., Yelos, D., Yeung, W., Yoshida, A., Yoshida, T., Yoshiike, S., Yoshikoshi, T., Yu, P., Zabalza, V., Zacharias, M., Zaharijas, G., Zajczyk, A., Zampieri, L., Zandanel, F., Zanin, R., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A., Zech, A., Zechlin, H., Zhao, A., Ziegler, A., Ziemann, J., Ziętara, K., Ziółkowski, J., Zitelli, V., Zoli, A., Zurbach, C., and Żychowski, P.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

List of contributions from the CTA Consortium presented at the 34th International Cosmic Ray Conference, 30 July - 6 August 2015, The Hague, The Netherlands., Comment: Index of CTA conference proceedings at the ICRC2015, The Hague (The Netherlands). v1: placeholder with no arXiv links yet, to be replaced once individual contributions have been all submitted; v2: final with arXiv links to all CTA contributions and full author list

Published
2015

29. Major Depressive Disorder and Oxidative Stress: A Review of Peripheral and Genetic Biomarkers According to Clinical Characteristics and Disease Stages

Author

Abd El Kader Ait Tayeb, Vianney Poinsignon, Kenneth Chappell, Jérôme Bouligand, Laurent Becquemont, and Céline Verstuyft

Subjects
major depressive disorder, antidepressant, clinical heterogeneity, oxidative stress, antioxidant defense, Therapeutics. Pharmacology, RM1-950
Abstract

Major depressive disorder (MDD) is currently the main cause of disability worldwide, but its pathophysiology remains largely unknown, especially given its high heterogeneity in terms of clinical phenotypes and biological characteristics. Accordingly, its management is still poor. Increasing evidence suggests that oxidative stress, measured on various matrices such as serum, plasma or erythrocytes, has a critical role in MDD. The aim of this narrative review is to identify serum, plasma and erythrocyte biomarkers of oxidative stress in MDD patients according to disease stage and clinical features. Sixty-three articles referenced on PubMed and Embase between 1 January 1991, and 31 December 2022, were included. Modifications to antioxidant enzymes (mainly glutathione peroxidase and superoxide dismutase) in MDD were highlighted. Non-enzymatic antioxidants (mainly uric acid) were decreased in depressed patients compared to healthy controls. These changes were associated with an increase in reactive oxygen species. Therefore, increased oxidative damage products (principally malondialdehyde, protein carbonyl content and 8-hydroxy-2′-deoxyguanosine) were present in MDD patients. Specific modifications could be identified according to disease stages and clinical features. Interestingly, antidepressant treatment corrected these changes. Accordingly, in patients in remission from depression, oxidative stress markers were globally normalized. This narrative review suggests the particular interest of oxidative stress biomarkers for MDD care that may contribute to the heterogeneity of the disease and provide the opportunity to find new therapeutic targets.

Published
2023
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30. Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Author

Kakou G. Aka, Dipomin F. Traoré, André B. Sagna, Dounin D. Zoh, Serge B. Assi, Bertin N’cho Tchiekoi, Akré M. Adja, Franck Remoue, and Anne Poinsignon

Subjects
Plasmodium falciparum, Malaria, Immunity, Salivary proteins, Anopheles, Exposure, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In malaria-endemic areas, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. The consequences on pathogen-specific immune responses are not well known. This study evaluated and compared the humoral responses specific to merozoite stage vaccine candidates of Plasmodium falciparum, in children differentially exposed to Anopheles bites in a natural setting. Methods The cross-sectional study was carried out in Bouaké (Côte d’Ivoire) where entomological data and blood samples from children (0–14 years) were collected in two sites with similar malaria prevalence. Antibody (IgG, IgG1, IgG3) responses to PfAMA1 and PfMSP1 were evaluated by ELISA. Univariate and multivariate analysis were performed to assess the relationship between the immune responses to P. falciparum antigens and exposure to Anopheles bites in the total cohort and in each site, separately. The individual level of exposure to Anopheles bites was evaluated by quantifying specific IgG response to the Anopheles gSG6-P1 salivary peptide, which represents a proxy of Anopheles exposure. Results The anti-Plasmodium humoral responses were different according to the level of exposure of children, with those highly exposed to Anopheles presenting significantly lower antibody responses to PfMSP1 in total population (IgG and IgG3) and in Petessou village (IgG, IgG1, IgG3). No significant difference was seen for PfAMA1 antigen between children differently exposed to Anopheles. In Dar-es-Salam, a neighbourhood where a high Culex density was reported, children presented very low antibody levels specific to both antigens, and no difference according to the exposure to Anopheles bites was found. Conclusion These findings may suggest that immunomodulatory components of Anopheles saliva, in addition to other factors, may participate to the modulation of the humoral response specific to Plasmodium merozoite stage antigens. This epidemiological observation may form a starting point for additional work to decipher the role of mosquito saliva on the modulation of the anti-Plasmodium acquired immunity and clinical protection in combining both field and ex vivo immunological studies.

Published
2020
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32. First evaluation of antibody responses to Culex quinquefasciatus salivary antigens as a serological biomarker of human exposure to Culex bites: A pilot study in Côte d'Ivoire.

Author

Bi Zamble H Zamble, Serge S Yao, Akré M Adja, Mahfoud Bakli, Dounin D Zoh, Françoise Mathieu-Daudé, Serge B Assi, Franck Remoue, Lionel Almeras, and Anne Poinsignon

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

BackgroundCulex mosquitoes are vectors for a variety of pathogens of public health concern. New indicators of exposure to Culex bites are needed to evaluate the risk of transmission of associated pathogens and to assess the efficacy of vector control strategies. An alternative to entomological indices is the serological measure of antibodies specific to mosquito salivary antigens. This study investigated whether the human IgG response to both the salivary gland extract and the 30 kDa salivary protein of Culex quinquefasciatus may represent a proxy of human exposure to Culex bites.Methodology/principal findingsA multidisciplinary survey was conducted with children aged 1 to 14 years living in neighborhoods with varying exposure to Culex quinquefasciatus in the city of Bouaké, Côte d'Ivoire. Children living in sites with high exposure to Cx quinquefasciatus had a significantly higher IgG response to both salivary antigens compared with children living in the control site where only very few Culex were recorded. Moreover, children from any Culex-high exposed sites had significantly higher IgG responses only to the salivary gland extract compared with children from the control village, whereas no difference was noted in the anti-30 kDa IgG response. No significant differences were noted in the specific IgG responses between age and gender. Sites and the use of a bed net were associated with the level of IgG response to the salivary gland extract and to the 30 kDa antigen, respectively.Conclusions/significanceThese findings suggest that the IgG response to Culex salivary gland extracts is suitable as proxy of exposure; however, the specificity to the Culex genus needs further investigation. The lower antigenicity of the 30 kDa recombinant protein represents a limitation to its use. The high specificity of this protein to the Culex genus makes it an attractive candidate and other specific antibody responses might be more relevant as a biomarker of exposure. These epidemiological observations may form a starting point for additional work on developing serological biomarkers of Culex exposure.

Published
2021
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33. HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007–12: impact on susceptibility to first-line strategies

Author

Frange, Pierre, Assoumou, Lambert, Descamps, Diane, Chéret, Antoine, Goujard, Cécile, Tran, Laurent, Gousset, Marine, Avettand-Fenoël, Veronique, Bocket, Laurence, Fafi-Kremer, Samira, Guinard, Jerome, Morand-Joubert, Laurence, Nicot, Florence, Plantier, Jean-Christophe, Rogez, Sylvie, Wirden, Marc, Rouzioux, Christine, Meyer, Laurence, Chaix, Marie-Laure, Abel, S, Abraham, B, Allegre, T, Antoniotti, A, Armero, R, Audhuy, B, Aumaitre, H, Beaucaire, G, Beck-Wirth, G, Berger, JL, Bernard, L, Beuscart, C, Bodard, L, Bouchaud, O, Boué, F, Cabane, J-P, Cabie, A, Champagne, H, Cheneau, C, Chennebault, J-M, Cheret, A, Christian, B, Compagnucci, A, Daneluzzi, V, Debab, Y, Dellamonica, P, Delfraissy, J-F, Devidas, A, Diab, G, Doll, J, Drobacheff-Thebaut, MC, Durel, A, Duvivier, C, Esnault, J-L, Faba, L, Froguel, E, Garipuy, D, Garrait, V, Geffray, L, Genet, C, Genet, P, Gerard, L, Ghosn, J, Girard, J-J, Girard, P-M, Godin-Collet, C, Hochedez, P, Hoen, B, Houlbert, D, Jacomet, C, Jeantils, V, Jidar, K, Katlama, C, Klement, E, Lafeuillade, A, Lascoux, C, Launay, V, Lepretre, A, Levy, Y, Makhloufi, D, Malbec, D, Martha, B, May, T, Merrien, D, Miailhes, P, Miodovski, C, Molina, J-M, Morlat, P, Mortier, E, Neau, D, Obadia, M, Patey, O, Pellegrin, J-L, Perronne, V, Philibert, P, Pialoux, G, Pichancourt, G, Piroth, L, Poinsignon, Y, Poizot-Martin, I, and Prazuck, T

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, HIV/AIDS, Antimicrobial Resistance, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Anti-HIV Agents, Disease Transmission, Infectious, Drug Resistance, Viral, Female, France, Genotype, Genotyping Techniques, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, Mutation, Missense, Prevalence, resistance-associated mutations, primary HIV infection, French ANRS CO 6 PRIMO Cohort, the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups, French ANRS CO 6 PRIMO Cohort the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups, Microbiology, Pharmacology and Pharmaceutical Sciences, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

BackgroundOur study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection (PHI) in 2007-12.MethodsHIV-1 resistance-associated mutations (RAMs) were characterized using both the 2009 WHO list of mutations and the French ANRS algorithm. A genotypic susceptibility score was estimated for each first-line recommended ART combination.ResultsPatients were mainly MSM (72.6%). Non-B variants were identified in 33.7% of patients. The proportion of TDR was estimated as 11.7% (95% CI 10.0-13.5). The prevalences of PI-, NRTI-, first-generation NNRTI and etravirine/rilpivirine-associated RAMs were 2.5%, 5.2%, 3.9% and 3.2%, respectively. Single, dual and triple class resistance was found in 9.6%, 1.0% and 1.1% of cases, respectively. Additionally, 5/331 strains isolated in 2010-12 had integrase inhibitor (II)-related RAMs (isolated E157Q mutation in all cases). TDR was more common among MSM than in other groups (12.9% versus 8.6%, P = 0.034), and in case of B versus non-B subtype infections (13.6% versus 7.9%, P = 0.002). The proportions of fully active combinations were ≥99.2%, ≥97.3% and ≥95.3% in cases of PI-, II- and NNRTI-based regimens, respectively. In 2010-12, the proportion of fully active efavirenz-based ART was lower in cases of subtype B versus non-B infection (P = 0.021).ConclusionsCompared with our previous studies, the proportion of NRTI- and first-generation NNRTI-related TDR has continued to decline in French seroconverters. However, subtype B-infected MSM could drive the spread of resistant HIV strains. Finally, we suggest preferring PI- or II- to NNRTI-based combinations to treat PHI patients.

Published
2015

36. Clinical and genetic features of patients suffering from CMT4J

Author

Beloribi-Djefaflia, Sadia, primary, Morales, Raul Juntas, additional, Fatehi, Farzad, additional, Isapof, Arnaud, additional, Servais, Laurent, additional, Leonard-Louis, Sarah, additional, Michaud, Maud, additional, Verdure, Pierre, additional, Gidaro, Teresa, additional, Pouget, Jean, additional, Poinsignon, Vianney, additional, Bonello-Palot, Nathalie, additional, and Attarian, Shahram, additional

Published
2023
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38. Exploring the heterogeneity of human exposure to malaria vectors in an urban setting, Bouaké, Côte d’Ivoire, using an immuno-epidemiological biomarker

Author

Dipomin F. Traoré, André B. Sagna, Akré M. Adja, Dounin D. Zoh, Kouassi A. Adou, Kouassi N. Lingué, Issa Coulibaly, N’Cho Bertin Tchiekoi, Serge B. Assi, Anne Poinsignon, Mamadou Dagnogo, and Franck Remoue

Subjects
Urban malaria, salivary biomarker of exposure, Anopheles, Transmission risk, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In some African cities, urban malaria is a threat to the health and welfare of city dwellers. To improve the control of the disease, it is critical to identify neighbourhoods where the risk of malaria transmission is the highest. This study aims to evaluate the heterogeneity of malaria transmission risk in one city (Bouaké) in a West African country (Côte d’Ivoire) that presents several levels of urbanization. Methods Two cross-sectional studies were conducted in three neighbourhoods (Dar-es-Salam, Kennedy and N’gattakro) in Bouaké during both the rainy and dry seasons. Data on insecticide-treated net (ITN) use and blood samples were collected from children aged between 6 months and 15 years to determine the parasite density and the prevalence of Plasmodium falciparum and the level of IgG against the Anopheles gSG6-P1 salivary peptide, used as the biomarker of Anopheles bite exposure. Results The specific IgG levels to the gSG6-P1 salivary peptide in the rainy season were significantly higher compared to the dry season in all neighbourhoods studied (all p

Published
2019
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39. Serological biomarker for assessing human exposure to Aedes mosquito bites during a randomized vector control intervention trial in northeastern Thailand.

Author

Benedicte Fustec, Thipruethai Phanitchat, Sirinart Aromseree, Chamsai Pientong, Kesorn Thaewnongiew, Tipaya Ekalaksananan, Dominique Cerqueira, Anne Poinsignon, Eric Elguero, Michael J Bangs, Neal Alexander, Hans J Overgaard, and Vincent Corbel

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

BackgroundAedes mosquitoes are vectors for several major arboviruses of public health concern including dengue viruses. The relationships between Aedes infestation and disease transmission are complex wherein the epidemiological dynamics can be difficult to discern because of a lack of robust and sensitive indicators for predicting transmission risk. This study investigates the use of anti-Aedes saliva antibodies as a serological biomarker for Aedes mosquito bites to assess small scale variations in adult Aedes density and dengue virus (DENV) transmission risk in northeastern Thailand. Individual characteristics, behaviors/occupation and socio-demographics, climatic and epidemiological risk factors associated with human-mosquito exposure are also addressed.MethodsThe study was conducted within a randomized clustered control trial in Roi Et and Khon Kaen provinces over a consecutive 19 months period. Thirty-six (36) clusters were selected, each of ten houses. Serological and entomological surveys were conducted in all houses every four months and monthly in three sentinel households per cluster between September 2017 and April 2019 for blood spot collections and recording concurrent immature and adult Aedes indices. Additionally, the human exposure to Aedes mosquito bites (i.e., Mosquito Exposure Index or MEI) was estimated by ELISA measuring levels of human antibody response to the specific Nterm-34 kDa salivary antigen. The relationships between the MEI, vector infestation indices (adult and immature stages) and vector DENV infection were evaluated using a two-level (house and individual levels) mixed model analysis with one-month lag autoregressive correlation.ResultsThere was a strong positive relationship between the MEI and adult Aedes (indoor and outdoor) density. Individuals from households with a medium mosquito density (mean difference: 0.091, pConclusionThis study represents an important step toward the validation of the specific IgG response to the Aedes salivary peptide Nterm-34kDa as a proxy measure for Aedes infestation levels and human-mosquito exposure risk in a dengue endemic setting. The use of the IgG response to the Nterm-34 kDa peptide as a viable diagnostic tool for estimating dengue transmission requires further investigations and validation in other geographical and transmission settings.

Published
2021
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41. The Drift Chambers Of The Nomad Experiment

Author

Anfreville, M., Astier, P., Authier, M., Baldisseri, A., Banner, M., Besson, N., Bouchez, J., Castera, A., Cloue, O., Dumarchez, J., Dumps, L., Gangler, E., Gosset, J., Hagner, C., Jollec, C., Lachaud, C., Letessier, A., Levy, J. M., Linssen, L., Meyer, J. P., Ouriet, J. P., Passerieux, J. P., Pedrol, T., Placci, A., Poinsignon, J., Popov, B., Rathouit, P., Schahmaneche, K., Stolarczyk, T., Uros, V., Vannucci, F., Vo, M., and Zaccone, H.

Subjects
High Energy Physics - Experiment
Abstract

We present a detailed description of the drift chambers used as an active target and a tracking device in the NOMAD experiment at CERN. The main characteristics of these chambers are a large area, a self supporting structure made of light composite materials and a low cost. A spatial resolution of 150 microns has been achieved with a single hit efficiency of 97%., Comment: 42 pages, 26 figures

Published
2001
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43. The French Integrative Psychosocial Rehabilitation Assessment for Complex Situations (FIPRACS): Modelization of an Adapted Assessment Method Toward Long-Term Psychiatric Inpatients With Disabling, Severe and Persistent Mental Illness

Author

Christophe Clesse, S. Salime, I. Dumand, S. Barbier Concetta-Ciciarelli, S. Lavenir, K. Kacemi, P. Heckel-Chalet, Frank Sissung, Aurore Poinsignon, Anthony Simon, M. Decker, and M. Batt

Subjects
psychosocial rehabilitation (PSR), psychological assessment, Rorschach, anamnesis, chronic psychosis, neuropsychological evaluation, Psychiatry, RC435-571
Abstract

For the past forty years, the generalization of community-based approaches has prompted psychiatry into promoting a deinstitutionalization movement and a psychosocial rehabilitation approach (PSR) for individuals with schizophrenia and related difficulties. Unfortunately, this approach generally does not involve the most severe cognitive and psycho-affective clinical situations among this population despite an increasing number of publications advocating that all individuals should be included in PSR and deinstitutionalization programs. In this context, considering the absence of an assessment battery designed for French individuals with particularly disabling, severe, and persistent mental illness (IDSPMI), we constructed an integrative assessment model adapted to this specific population. To select the most suitable tools for this population, a literature review (inspired by the PRISMA protocol) and a systematic review were combined with a clinical assessment study. The literature review first identified the cognitive and psycho-affective functions which mainly influence the day-to-day life adaptation of individuals engaged in a PSR/deinstitutionalization program. The systematic review then gathered all of the useable French validated tools to assess the initially selected dimensions (n = 87). To finish, for each dimension, the selected 87 tools were included in a clinical assessment study performed within a French psychiatric hospital. The authors collected and verified the characteristics of each tool (validity, French norms, French version, the average speed of the test, ease of use, ability to assess other dimensions). Their suitability was also assessed when applied to IDSPMI. Based on this final clinical evaluation, the authors selected one tool per function to create the French Integrative Psychosocial Rehabilitation Assessment for Complex Situations (FIPRACS). This battery is an assessment tailored to the neurocognitive and psycho-affective potentials of IDSPMI. While further validation studies of this battery are ultimately required, the practical/clinical implications of this battery are presented and discussed.

Published
2020
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44. Gelatin Methacryloyl (GelMA) Hydrogel Scaffolds: Predicting Physical Properties Using an Experimental Design Approach

Author

Peyret, Corentin, primary, Elkhoury, Kamil, additional, Bouguet-Bonnet, Sabine, additional, Poinsignon, Sophie, additional, Boulogne, Corentin, additional, Giraud, Tristan, additional, Stefan, Loïc, additional, Tahri, Yasmina, additional, Sanchez-Gonzalez, Laura, additional, Linder, Michel, additional, Tamayol, Ali, additional, Kahn, Cyril J.F., additional, and Arab-Tehrany, Elmira, additional

Published
2023
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45. Phenotype Presentation and Molecular Diagnostic Yield in Non-5q Spinal Muscular Atrophy

Author

Fernández-Eulate, Gorka, primary, Theuriet, Julian, additional, Record, Christopher J., additional, Querin, Giorgia, additional, Masingue, Marion, additional, Leonard-Louis, Sarah, additional, Behin, Anthony, additional, Le Forestier, Nadine, additional, Pegat, Antoine, additional, Michaud, Maud, additional, Chanson, Jean-Baptiste, additional, Nadaj-Pakleza, Aleksandra, additional, Tard, Celine, additional, Bedat-Millet, Anne-Laure, additional, Sole, Guilhem, additional, Spinazzi, Marco, additional, Salort-Campana, Emmanuelle, additional, Echaniz-Laguna, Andoni, additional, Poinsignon, Vianney, additional, Latour, Philippe, additional, Reilly, Mary M., additional, Bouhour, Francoise, additional, and Stojkovic, Tanya, additional

Published
2023
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47. Safety, tolerability and antitumour activity of LY2780301 (p70S6K/AKT inhibitor) in combination with gemcitabine in molecularly selected patients with advanced or metastatic cancer: a phase IB dose escalation study

Author

Angevin, Eric, Cassier, Philippe A., Italiano, Antoine, Gonçalves, Anthony, Gazzah, Anas, Terret, Catherine, Toulmonde, Maud, Gravis, Gwenaëlle, Varga, Andrea, Parlavecchio, Cédric, Paci, Angelo, Poinsignon, Vianney, Soria, Jean-Charles, Drubay, Damien, and Hollebecque, Antoine

Published
2017
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49. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study

Author

Hausfater, Pierre, Pourriat, Jean-Louis, Casalino, Enrique, Riou, Bruno, Pateron, Dominique, Yéni, Patrick, Bricaire, François, Ville, Yves, Azria, Elie, Dommergues, Marc, Bergmann, Jean-François, Wolff, Michel, Mira, Jean-Paul, Guillevin, Loïc, Zuber, Mathieu, Abasse, Soumeth, Aberrane, Saïd, Abgueguen, Pierre, Abokasem, Ayman, Abraham, Bruno, Ache-Papillon, Chantal, Adam, Pascal, Adam, Marie-Noëlle, Adhoute, Xavier, Adoue, Daniel, Afi, Moncef, Afroukh, Nawel, Agha-Mir, Ilhem, Aissa, Nejla, Aissaoui, Liamine, Akerman, Grégory, Akkari, Ali, Al Chaar, Majed, Al Freijat, Faraj, Al-Jalaby, Bachar, Albert, Didier, Albertini, Marie-Thérèse, Albinet, Hélène, Alfonsi, Gwenaël, Ali, Youssef, Chaouche, Zahr-Eddine Ali, Allart, Anne, Alric, Laurent, Améri, Alain, Amoura, Zahir, Ampère, Alexandre, Amroun, Hakim, Ananivi, Amévi, Ancelin, Pascal, André, Thierry, Andremont, Antoine, Andreotti, Dominique, Andriamaneo, Hélinoro, Andriau, Clara, Anglaret, Hélène, Anguel, Nadia, Annaix, Véronique, Anteur, Wassila, Anuset, Delphine, Aoudia, Ourida, Arabi, Miloud, Archambaud, Muriel, Archambaud, Maryse, Ardiet, Emmanuel, Argaud, Laurent, Arista, Sophie, Arlet, Guillaume, Armengaud, Jean, Arnal, Jean-Michel, Arnault, Isabelle, Arsène, Olivier, Assaf, Ziad, Assi, Assi, Assouline, David, Astruc, Dominique, Aubard, Yves, Aubert, Claude, Aubry, Jean-Paul, Auburtin, Marc, Aucher, Philippe, Audeguy, Philippe, Audié, Jean-Pierre, Aumaitre, Hugues, Aumersier, Michel, Auroux, Jean, Autret, Fanny, Auvray, Etienne, Ayach, Badih, Aye, Paul, Ayouz, Khélifa, Bachelier, Marie-Nadège, Badia, Thomas Bachelot Philippe, Badila, Patrice, Bador, Julien, Badurescu, Viorica, Baldesi, Olivier, Bandaly, Françoise, Bandin, Olivia, Bani-Sadr, Firouzé, Bannier, Stéphanie, Baranger, Thierry, Barazer, Isabelle, Barbier, Marie-Christine, Barbier, François, Barbier, Carole, Barbieux, Marianne, Marie, Barboteau, Annick, Barbut, Patricia, Baret, Mylène, Barière, François, Baril, Jean-Yves, Barillot, Isabelle, Barjon, Geneviève, Barnaud, Guilène, Barraduc, Régine, Barraud, Francis, Barraud, Olivier, Barre, Eric, Barrelet, Audrey, Barrier, Jocelyn, Bart, Fréderic, Barthélémy, Gérard, Baty, Gaëlle, Baud, Olivier, Baudel, Jean-Luc, Bay, Jacques-Olivier, Bay, Jérôme, Bazin, Claude, Beague, Sébastien, Beal Ardisson, Dominique, Beaune, Bertrand, Beauplet-Lepage, Anne, Bébéar, Cécile, Bechade, Dominique, Becherrawy, Céline, Becker-Schneider, Michelle, Bednarek, Nathalie, Bedock, Bernard, Begon, Edouard, Bekguesmia, Zaineb, Belaisch-Amart, Joëlle, Belhadj, Karim, Belle, Evelyne, Belmonte, Olivier, Belot, Jean-Pierre, Bemrah, Abdelkader, Ben Soltana, Mouna, Benbara, Amélie, Benddif-Fin, Faiza, Bénézit, François, Benifla, Jean-Louis, Benjelloul, Amine, Benkaci, Yacine, Benkhelil, Abdelaziz, Benoit-Cattin, Thierry, Benoit-Coustou, Sophie, Bensadoun, René-Jean, Bensaid, Thierry, Jacques Bensaude, Raoul, Bérard, Henri, Bercot, Béatrice, Berdin, Bruno, Berger, Marc, Berger, Pierre, Bergheul, Smail, Bergues, Benoît, Berland, Yvon, Bernard, Claude, Bernard, Louis, Bernardaud, Bérangère, Bernardi, Franck, Bernardin, Gilles, Bernasconi, François, Bert-Marcaz, Patrick, Berteaux, Béatrice, Berth-Farges, Anne, Berthelot, Gilles, Berthet, Jean, Bertrand, Kevin, Bertrou, Anne, Besnard, Marianne, Bessede, Emilie, Bethery, Philippe, Beuscart, Claude, Beyne-Rauzy, Odile, Beytout, Jean, Bezian, Marie-Christine, Bicais, Brigitte, Bidart, Sabine, Bidault, Christian, Biessy, Hélène, Bigot, Pierre, Bildea, Adrianna, Bille, Emmanuelle, Billy, Christophe, Biron, Nathalie, Bizet, Jérôme, Blaise, Didier, Blaise, Agathe, Blaison, Gilles, Blaka, Mariam, Blanc, Pierre, Blanc, Stéphane, Blanc-Amrane, Véronique, Blanchard, Pierre, Blanchard-Marche, Geneviève, Blancs, Michèle, Blazejewski, Caroline, Bléher, Yves, Blewoussi, Koffi, Blondet, Romain, Blot, François, Blum, Georges-Fabrice, Bodson, Lucien, Boidin, Emilie, Boileau, Julien, Boileau, Pascal, Boin-Gay, Véronique, Boisseau, Martial, Boisselier, Christine, Bollaert, Pierre-Edouard, Bolot, Pascal, Bonacorsi, Stéphane, Bonfils, Marie, Bonitchi, Pascal, Bonnan, Mickael, Bonnefoy, Philippe, Bonnet, Delphine, Bonnet, Richard, Bonnin, Emmanuelle, Bor, Jacques, Borie, Marie-Françoise, Borstein, Bernard, Bossi, Philippe, Botreau, Yves, Bottero, Julie, Bouasria, Abderrezak, Bouaziz, Radia, Bouchaud, Olivier, Bouche, Flore, Bouchet, Gérard, Bouden, Vincent, Boudhane, Amar, Boudy, Carole-Anne, Boue, François, Bouet, Cédric, Claude Boufetteau, Jean, Bouffandeau, Bernard, Bouhour, Damien, Bouiller, Marc, Bouillet, Laurence, Bouissou, Antoine, Boulain, Luc, Bourgeois, Stéphane, Bourgerette, Evelyne, Bourlet, Anne, Bourlière, Marc, Bourrée, Thomas, Bourrouillou, Aude, Boussekey, Nicolas, Boussier, Remi, Boutoille, David, Bouyer, Jean-Luc, Bouyssou-Destriau, Denise, Bouziges, Nicole, Boyer, Michelle, Braem, Louis, Branger, Bernard, Branger, Catherine, Brasme, Lucien, Bray, Philippe, Brazille, Patricia, Bresson, Violaine, Bret, Laurent, Breton, Anne-Laure, Breuil, Jacques, Brevet, Françoise, Briaud, Michel, Bridoux, Delphine, Briend, Delphine, Briere, Anne-Isabelle, de la Hosseraye, Claire Briere, Brieu, Nathalie, Brieux, Jean-Philippe, Brihier, Hélène, Brisou, Patrick, Brival, Marie-Laure, Broche, David, Brochen, Joëlle, Bron, Camille, Bronet, Nathalie, Bronner, Jacques, Bronowicki, Jean-Pierre, Brosset, François, Brottier-Mancini, Elisabeth, Brovedani, Sophie, Bruley des Varannes, Stanislas, Brunel, Pascale, Brunet, Patrick, Brunet, Xavier, Brunet, Stéphanie, Brung-Lefebvre, Maud, Brunot, Vincent, Brusset, Alain, Burc-Struxiano, Laurence, Burdin, Michèle, Bureau, Thierry, Buron, Fanny, Burucoa, Christophe, Cabalion, Jean, Cabasson, Severine, Cabié, André, Cacheux, Victoria, Cadiergue, Vincent, Cadiot, Guillaume, Caille, Vincent, Cailleaux Pierre-Etienne Cailleux, Vincent, Caillon, Jocelyne, Caillot, Denis, Camara, Mohamed, Cambau, Emmanuelle, Cambonie, Gilles, Camiade, Sabine, Canis, Frederique, Canitrot, Meriem, Canu, Nathalie, Capellier, Gilles, Carbillon, Lionel, Carbonelle, Bernard, Carbonelle, Etienne, Carboni, Marion, Carbonne, Bruno, Carcenac, Francis, Cardot, Florence, Carette, Sylvie, Cariou, Sylvie, Carli, Pierre, Carmagnol, Françoise, Caroli-Bosc, François-Xavier, Caron, François, Cartron, Guillaume, Casali, Patrick, Casanovas, Olivier, Cassignard, Dominique, Castaing, Denis, Castel, Brisse, Castelin, Sandrine, Castelnau, Pierre, Cathebras, Pascal, Catineau, Jean, Catteu, Sylviane, Cattier, Blandine, Cattoen, Christian, Cattoir, Vincent, Caumes, Eric, Caussin, Jean, Cavalié, François, Ceppa, Franck, Cerf, Charles, Ceriez, Anne, Cervantes, Nathalie, Chabanon-Pouget, Bruno, Chabrol, Amélie, Chachaty, Elisabeth, Chahtour, Hanen, Chaix, Fabrice, Challier, Marion, Chalvon-Demersay, Arnaud, Chambreuil, Guy, Chaminade, Bruno, Chamouine, Abdourahim, Chandesris Joséphine Chapalain-Cagnon, Christine, Chapelle, Alain, Chaplain, Chantal, Chapuzet, Claire, Charachon, Sylvie, Charasse, Christophe, Charbonnier, Thierry, Charlier, Franck, Chassin, Olivier, Chassy, Véronique, Chatellier, Delphine, Chatron, Marlène, Chaussade, Hélène, Chavanet, Pascal, Chavel, Pascale, Chekroun, Ali, Chelle, Wladimir, Chelly, Jonathan, Cherlet, Christel, Chevailler, Alain, Chevalet, Pascal, Chevalier, Yannick, Chidiac, Christian, Chimot, Loïc, Chiouk, Nabil, Chiron, Philippe, Chirouze, Catherine, Chopin, Marie-Charlotte, Choukroun, Gabriel, Chouraqui, Martine, Chraibi, Kamilla, Chudersky, Dominique, Chuzeville, Michel, Cingotti, Michel, Cinquetti, Gael, Ciocan, Dragos, Citony, Isabelle, Claise, Catherine, Clarissou-Philippe, Juliette, Claude, Benoît, Clave, Danielle, Clément, Christophe, Climas, Marie-Thérèse, Coetmeur, Daniel, Cognet, Stéphanie, Cohen, Daniel, Coignard, Sophie, Coindre, Jean-Philippe, Coint, Raphaël, Colamarino, Renato, Colingorski, Anne-Marie, Collard, Olivier, Collet, Michel, Collignon, Anne, Collus, Marie-José, Colombani, Jean-Claude, Colombat, Philippe, Combe, Christian, Condominas, Philippe, Conroy, Marie-Chrsitine, Constans, Thierry, Constantin, Nicole, Contamin, Claudine, Corberand, Damien, Cordier, Anne-Marie, Cordonnier, Charlotte, Corneloup, Hélène, Costa, Yannick, Costa, Frédérique, Coste, Mathieu, Costes, Corinne, Cotes, Françoise, Cotteret, Rabea, Couderc, Louis-Jean, Cougoul, Pierre, Coulaud, Jean-Michel, Coulhon, Marie-Pierre, Coulon, Patrice, Courcol, René, Courillon, Florence, Courjon, Johan, Courouble, Jérémie, Courouge-Dorcier, Dominique, Courtade, Henri, Courtois, Stéphanie, Couturier, Pascal, Créange, Alain, Cremet, Lise, Cremniter, Julie, Croize, Jacques, Crombe, Valérie, Croquet, Ingrid, Cua, Eric, Cufi, Marie-Noelle, Cuvillier, Patrice, Dabysing, Marie-Françoise, Dadoun, Karim, Dagada, Corinne, Dahan, Sonia, Dahoumane, Redouane, Daleas, Jacques, Dallay, Dominique, Dalle, Benoît, Damage, Alexandre, Damaj, Lena, Damaj Gandhi, Laurent, Danalaché, Ana, Danin, Pierre-Eric, Danjean, Marie-Pierre, Danquechin Dorval, Etienne, Dao, Anne, Daoud, Patrick, Darchen, Olivier, Dargère, Sylvie, Darre, Bincy, Dassant, Damien, Dassieu, Gilles, Dattin-Dorrière, Valérie, Daupin, Cedric, Daurel, Claire, Dausset, Jean-Claude, Daval Cote, Mélanie, David, Gary, Davido, Benjamin, De Barbeyrac, Bertille, De Biasi, Michel, De Boysson, Hubert, De Clareuil, Edith, De Kermadec, Jean-Michel, De Martino, Sylvie, De Tayrac, Renaud, De Varax, Roland, De Witte, Sten, Debernardi, Anne, Deboutin, Jean-Luc, Debouverie, Marc, Decoene, Christophe, Decoster, Anne, Decousser, Jean-Winoc, Decré, Dominique, Defebvre, Renaud, Degand, Nicolas, Degreff, Jean-Marc, Deiber, Michel, Delaby, Hélène, Delacour, Thierry, Delahaye, Arnaud, Delarbre, Jean-Marie, Delasalle, Chantal, Delbrouck, Claire, Delecalle, Jean-Gilles, Delesalle, Sophie, Delesalle, Chantal, Delhoustal, Laurence, Deligne, Delphine, Delisle Mizon, Françoise, Delobel, Pierre, Delour, Pierre, Delpeuch, Bruno, Demachy, Marie-Claude, Demarchi, Martin, Demarcq, Marie-Joelle, Demontclos, Henri, Dengo, Jean-Christophe, Deprecq, Sophie, Dequin, Pierre-François, Dereeper, Olivier, Deroux, Alban, Derragui, Aicha, Desblache, Julien, Desbois-Nogard, Nicole, Descamps, Dominique, Descamps, Jean-Michel, Deschamps, Christophe, Deschamps, Jacques, Desemerie, Franck, Desfrere, Luc, Desliers, Joelle, Desnoulez, Laurence, Desplaces, Nicole, Després, Nicolas, Dessin, Jean-François, Destors, Marie, Detante, Olivier, Detave, Mathieu, Detourmignies, Laurence, Devaud, Edouard, Devaux, Yves, Devaux, Bruno, Devianne, François, Devidas, Alain, Devos, Philippe, Dewitte, Camille, Dewulf, Gisèle, Dhennain, Chantal, Di Meglio, Chloé, Diallo, Habiboulaye, Diamantis, Sylvain, Dib, Baihas, Didier, Jean-Marc, Dillies, Anne-Françoise, Dingremont, Claire, Djafari, Noureddine, Djeffal, Abdelmajid, Djerad, Hama, Dollon, Christophe, Doloy, Alexandra, Domart, Yves, Donay, Jean-Luc, Dopeux, Loïc, Dorr, Gaelle, Doucet Populaire, Florence, Dournon, Nathalie, Dreyfus, Michel, Dreyfuss, Didier, Du Cheyron, Damien, Dubois, Elodie, Dubois, Nicolas, Dubosc-Marchenay, Nadine, Dubourdieu, Béatrice, Dubroca, Nadine, Dubus, Jean-Christophe, Duche, Catherine, Duchene, Francis, Dudeffant, Patrick, Duez, Jean-Marie, Duhaut, Pierre, Duluc, Françoise, Dumouchel, Hélène, Dumoulard, Bruno, Dupin, Clarisse, Dupon, Michel, Dupont, Mathieu, Dupont, Damien, Dupont, Patrick, Dupre-Narlet, Emmanuelle, Dupretz, Peggy, Dupuy, Claire-Antoinette, Durand, Michel, Durand, Annie, Durliat-Ellie, Solène, Durox, Hélène, Dussopt, Christine, Dutasta, Fabien, Duval, Véronique, Dzeing, Ella, Eboue, Florence, Ede, Cyrille, Eid, Hanna, El Yamani, Abderrazak, Elbez, Annie, Eldeghedy, Mohamed, Elena-Daumas, Martine, Elhadad, Simon, Elharie-Heraux, Zoubida, Eloy, Clarence, Emeriau, Marie-Etiennette, Emond, Jean-Philippe, Equy, Véronique, Erena-Penet, Anne-Sophie, Esnault, Cecilia, Esposito, Laure, Essouri, Sandrine, Estépa, Laurence, Estève, Vincent, Etchemendy, Sabine, Ettahar, Nicolas, Eustache, Marie-Line, Evillard, Mathieu, Evreux, Françoise, Eychene, Jean-Marc, Eyer, Didier, Eymerit, Philippe, Fabre, Jean-Luc, Fabre, Claire, Faibis, Frédéric, Falchero, Lionel, Falguières, Odile, Fallouh, Hassan, Fanjaud, Nicolas, Fantin, Bruno, Farah, Ibrahim, Farto-Bensasson, Fernanda, Fauchais, Anne-Laure, Fauchart, Jean-Pierre, Faucher, Anna, Faucheux, Jean-Marc, Faudon-Gibelin, Anne, Faurie, Pierre, Fèbre, Claudine, Feddal, Toufik, Ferhat Carre, Assia, Ferreira-Maident, Nicole, Ferreyra, Milagros, Ferroni, Agnès, Ferry, Tristan, Feugier, Pierre, Feugier, Jean-Claude, Fezoui, Hacene, Fiette, Hélène, Fille, Alexandra, Filloux, Jean-Michel, Fily, Fabien, Fines, Marguerite, Fissore Magdelein, Cristel, Flahault, Mathilde, Floriot, Christian, Foguem, Clovis, Fonsale, Nathalie, Fontenel, Benoît, Forest, Anne-Marie, Forest, Anne, Forestier, Emmanuel, Fortin, Louise, Fortineau, Nicolas, Fos, Marie-Pierre, Foucart, Saskia, Fouilhoux, Alain-Charles, Fournel, Pierre, Fournier, Damien, Fourrier, François, Fraisse, Thibaut, Fredenucci, Isabelle, Fremin-Batteux, Odile, Frey, Janine, Frimat, Luc, Froidure, Marie, Fruchart, Christophe, Fruleux, Nathalie, Fuhrmann, Christine, Fuillet, Michel, Funakoshi, Nathalie, Fur, Alain, Gabez-Therou, Patricia, Gaborieau, Valerie, Gabriel-Soléan, Sylvie, Gachassin, Laurence, Gaide, Jean-François, Gaillard, Julia, Gaillard, Jean-Louis, Gaillart, Tiphaine, Gaizi, Sad, Gallo, Nicolas, Gameiro, Manuel-Luis, Garandeau, Caroline, Garbi, Aurelie, Garcera, Yves, Gardes, Ghislaine, Garesslin, Olivier, Garnier, Fabien, Garofano, Marie, Garosi, Olivier, Garre, Michel, Garrec, Hélène, Garrigues, Bernard, Gaschet, Anne, Gascon, Alexandre, Gascou, Emmanuel, Gasnault, Jacques, Gatfosse, Marc, Gattault, Jean-François, Gatti, Hélène, Gauche, Bernard, Gaudard, Philippe, Gaudelus, Joel, Gaudry, Stéphane, Gauduchon, Valérie, Gaulthier, Jean-Baptiste, Gauthier, Yvan, Gebeile, Rémi, Geffray, Loïc, Geffroy, Françoise, Geissler, Alain, Gelez, Maud, Gendrin, Vincent, Gengembre, Guy, Gentilhomme, Hervé, Gérart Pons, Sandrine, Germain, Marie-Claude, Gesquière, Julien, Ghedira, Adel, Ghevaert, Christine, Gillot, Jean-Michel, Girard, Edouard, Girard, Serge, Girard, Pierre-Marie, Girard-Buttaz, Isabelle, Giraud, Martine, Glorieux, Isabelle, Goburdhun, Chandrah, Godin, Michel, Godon, Catherine, Goehringer, François, Goffart, Sylvie, Goidin, Isabelle, Goldgran Toledano, Daniele, Golfier, François, Goll, Armand, Gontieron, Olivier, Goquelin, Anne, Got, Laurence, Goudeau, Alain, Goujard, Cécile, Goupil, François, Gouraud, François, Gourlaouen, Alain, Gournay, Jérôme, Goustille, Julien, Goux, Alain, Grandclerc, Benoît, Grange, Jean-Didier, Granger, Thierry, Granier, Françoise, Granier, Michèle, Grasset, Denis, Gravet, Alain, Grawey, Isabelle, Greder Belan, Alix, Grelaud, Jean-Jacques, Grenet, Karine, Gressier, Bernard, Grignon, Bernadette, Grimprel, Emmanuel, Grise, Geneviève, Grobost, Vincent, Gross Goupil, Marine, Grossi, Olivier, Gruffat, Brigitte, Gruson, Anne, Guénard, Yves, Guérard, Arnaud, Guérin, Bruno, Guérin, Mathilde, Guérin, Claude, Guerquin, Bernard, Guerrot, Dominique, Guéry, Benoît, Gueudet, Philippe, Gueugniaud, Pierre-Yves, Guichard, Isabelle, Guichart, François, Guiden, Ozel, Guider, Bertrand, Guillarmé Grossmann, Pascale, Guillemot, François, Guillet, Pierre, Guillet-Caruba, Christelle, Guillois, Bernard, Guilloy, Olivier, Guimard, Thomas, Guimard, Karine, Guimier, Philippe, Guinard, Jérôme, Guinet, François, Guisset, Olivier, Guitteaud, Karine, Gutmann, Laurent, Guyetand, Severine, Haccourt, Fabian, Hacot, Jean-Pierre, Hadou, Tahar, Haiat, Stéphanie, Haioun, Corinne, Hajjar, Mostapha, Hamitou, Zakaria, Hammami, Sarah, Hamon-Charles, Sophie, Hamou-Plotkine, Laurence, Hanouz, Jean-Luc, Harbi, Samia, Harlé, Jean-Robert, Haro, Sophie, Harou, Christian, Harvey, Thierry, Hatem, Ghada, Hausermann, Marie-Hélène, Hauss, Pierre-Alexandre, Hayoun, Fabrice, Hecham, Moussa, Heches, Xavier, Hedjem, Nourredine, Heidt, Anne, Heisel, Nicolas, Heluwaert, Fréderic, Helvadjian, Thierry, Henni, Tawfiq, Henry-Andrieu, Yanne, Hequet, Delphine, Herbecq, Patrick, Herbrecht, Raoul, Hernu, Romain, Herry, Catherine, Herry, Jean-Paul, Herson, Serge, Heurtaux, Marie-Noelle, Heusse, Emmanuelle, Heyraud-Blanchet, Catherine, Hichri, Yoar, Hilbert, Gilles, Hili, Marie-Thérèse, Hiret, Sandrine, Hittinger, Gilles, Hochart, Anne-Cécile, Hodee, Nathalie, Holstein, Anne, Hombrouk-Alet, Cécile, Hominal, Stéphane, Honderlick, Patrick, Honoré Bouakline, Stéphanie, Hory, Bernard, Hourdebaigt-Larrusse, Pierre, Houssaye, Serge, Houssiaux-Maisonneuve, Nathalie, Hrichi, Abdelkader, Hubert, Didier, Huc, Benoît, Humbert, Karine, Hurel, Dominique, Husson-Wetzel, Stéphanie, Hutin, Pascal, Huttin, Bernard, Hyerle, Laura, Iacobelli, Silvia, Ilunga, Serge, Imbert, Guenièvre, Jabre-Sikias, Elias, Jacob, Jean-Louis, Jacobs, Romain, Jacomy, Dominique, Jacquier, Pascal, Jacquier, Hervé, Jaffarbandjee, Marie-Christine, Jamet, Angéline, Jan, Didier, Jang, Guyro, Jaouen, Anne-Christine, Jardel, Henry, Jarlier, Vincent, Jarrige, Luc, Jarrousse, Bernard, Jauhlac, Benoît, Jault, Véronique, Jault, Thierry, Jaunait, Eric, Javouhey, Etienne, Jean, Rodolphe, Jean, Julie, Jean-Pierre, Hélène, Jeanmaire, Eliette, Jeannot, Katy, Jeddi, Hassen, Jego, Mickael, Jennane, Selim, Join-Lambert, Olivier, Joly, Pascal, Jonquet, Olivier, Josien, Eric, Jouatte, Fabienne, Jouffret, Agnès, Jourde-Chiche, Noémie, Jourdes, Emilie, Jouvencel, Philippe, Jouzel, Charlotte, Julienne, Geneviève, Jullian, Eric, Juven, Agnès, Juvin, Philippe, Kaidomar, Michel, Kaiser, Thomas, Kalfon, Pierre, Kaltenbach, Georges, Kamar, Nassim, Kansau, Imad, Kara, Ali, Karaoui, Leila, Karirisi, Apollinaire, Karkous, Bernard, Kassis, Marie, Kayal, Samer, Keller, Marie, Kemenar, Chrystelle, Kennouche, Samir, Kerchache, Aissa, Kerleau, Jean-Marc, Kervegant, Anne-Gaelle, Khalifa-Thellier, Sandrine, Radhouane-Khanjari, Fethi, Kherouf, Hakim, Khodeir, Nordine, Kibbrecht, Eric, Kim, An, Kisterman, Jean-Paul, Kittschke, Bernard, Klapczynski, Frédéric, Kodzin, Marie-José, Konate, Bano, Kouaho, Sylvain, Koulmann, Laurence, Krechiem, Karim, Kubab, Sarah, Kubiak, Charles, Kurtz, Jean-Emmanuel, Labadie, Philippe, Labarrière, Damien, Labaune-Kiss, Andrea, Labé, Aurélie, Labourdette, Isabelle, Labrousse, Philippe, Labussière, Anne-Sophie, Lachenal, Florence, Lacroix, Jérôme, Lafeuillade, Alain, Lafforgue, Marie-Odile, Lafon, Ingrid, Lagasse, Jean-Pierre, Lagrandeur, Julien, Lalot, Jean-Marc, Lalu, Mélissa, Laluque, Simone, Lamache, Sébastien, Lamarca, Richard, Lamberet, Aurore, Lambert, Thierry, Lambiotte, Fabien, Lamia, Bouchra, Lamoine-Gimet, Ghislaine, Lamour, Armelle, Lamy, Brigitte, Lanba, Patrice, Landgraf, Nathalie, Landraud, Luc, Laporte, Jean-Patrick, Larible, Claire, Larrazet, Fabrice, Larroche, Claire, Lasbasses, Claudine, Lassel, Ludovic, Lassere, Bertrand, Laudat, Patrice, Lauque, Dominique, Laurens, Etienne, Laurent, Frédéric, Lauretta, Raphael, Laurin, Max, Lauzanne, Brigitte, Lavalard, Emmanuelle, Lavenu, Isabelle, Lavigne, Jean-Philippe, Le Baron, François, Le Berre, Rozenn, Le Berruyer, Pierre-Yves, Le Bideau, Marc, Le Boterff, Cécile, Le Chevallier, Sylvain, Le Coustumier, Alain, Le Du, Anne, Le Goff, Valérie, Le Henaff, Catherine, Le Lay, Geneviève, Le Maout, Gilles, Le Pierres, Athéna, Le Pimpec, Patricia, Le Poulain, Marguerite, Le Reste, Anne-Marie, Le Sec, Ludovic, Le Turdu, Françoise, Leautez-Nainville, Sophie, Lebas, Eddy, Leblond, Véronique, Lebreton, Marie-Annick, Lebreton, Didier, Lecaillon-Thibon, Evelyne, Lechat, Sylvie, Lechiche, Catherine, Lecis, Alain, Leclercq, Roland, Lecomte, Claire, Lécuyer, Hervé, Ledru, Sylvie, Leduc, Dominique, Leflon, Véronique, Lefort, Christine, Lefranc, Hélène, Lefrant, Jean-Yves, Legendre, Christophe, Legoff, Isabelle, Legout, Laurence, Legrand, Mathieu, Legras, Annick, Legros, Antoine, Leguen, Virginie, Leibinger, Franck, Lelièvre, Jean-Daniel, Lellouche, Franck, Lemaignen, Adrien, Lemarie, Romain, Lemble, Chantal, Lemenand, Olivier, Lemercier, Fanny, Lemery, Didier, Lemmens, Bruno, Lemyze, Malcolm, Leneveu, Michel, Léonetti, Françoise, Léonnet, Caroline, Léotard, Sophie, Lepeletier, Didier, Lepelletier, Didier, Lepeule, Raphael, Lepiller, Quentin, Lequen, Laurence, Leroux, Lionel, Leroux, Stéphane, Leroy, Hélène, Leroy, Vincent, Leroy, Olivier, Lesage, Fabrice, Lescat, Mathilde, Lesecq, Ludovic, Lessene, Aude, Lessinger, Jean-Marc, Letellier, Claire, Letellier, Nicolas, Letouzey, Vincent, Letranchant, Lorraine, Levast, Marion, Leveneur, Yann, Levent, Thierry, Levy, Marie, Levy, Marc, Leysenne, David, Libeau, Benoît, Likose, Ebutu, Lima, Suzanne, Lina, Gérard, Lioger, Bertrand, Lionnet, Benoît, Lipovac, Anne-Sophie, Loffeier, Vincent, Loison, Françoise, Lorchleac'h, Aurélien, Lorge, Fabienne, Loriferne, Jean-François, Lorléa'ch, Aurélien, Louart, Guillaume, Loury-Lariviere, Isabelle, Loustaud, Véronique, Lozniewski, Alain, Luciani, Roger-Charles, Luminitan Elena Lupean, Luca, Lureau, Pierre, Lutz-Murphy, Marie-France, Mbimba, Luwawu, M'Bey, Damien, Maakaroun, Abdallah, Macci, Valérie, Magdoud, Fatma, Mager, Guy, Magna, Théophile, Magny, Jean-François, Mahaza, Chetaou, Mahé, Isabelle, Maillard, Christine, Maillet, Jean-Jacques, Maillet, François, Maillez, Sébastien, Maillot, François, Maisonneuve, Antoine, Makdessi, Solène, Malbrunot, Claire, Malbruny, Brigitte, Malderet, Caroline, Malfuson, Jean-Valère, Malherbe, Philippe, Malherbe, Patrick, Malhiere, Sophie, Mandelbrot, Laurent, Mandin, Laurent, Mandjee, Aziza, Manéglier, Benjamin, Mansouria, Mohammed, Marcu, Elena, Mariette, Jean-Bernard, Mariette, Sylvie, Markarian, Jacques, Marmouset, Carole, Marpeau, Olivier, Marret, Olivier, Marsepoil, Thierry, Marterl-Lafay, Isabelle, Martha, Benoît, Marthelet, Patrick, Martin, Xavier, Martin, Florence, Martin, Pierre, Martin, Régine, Martin, Christian, Martin Lefèvre, Laurent, Martineau, Olivier, Martinet, Olivier, Martinez, Valérie, Martinot, Martin, Martres, Pascale, Marty, Sophie, Marty-Ane, Charles, Marzouk, Paul, Mascade, Géraldine, Masia, Florent, Masseron, Thierry, Masson, Loïc, Masson, Philippe, Matheron, Isabelle, Matica, Slavius, Matray, Olivier, Mattei, Marie-Françoise, Maubert, Bertrand, Maugein, Jeanne, Maureira, Juan-Pablo, May, Thierry, May, Adrien, Maze, Vincent, Meaudre Desgouttes, Eric, Mebazaa, Alexandre, Mechai, Frédéric, Medeau, Virginie, Megbemado, Richard, Mehri, Mona, Mein-Bottini, Myriam, Melis, Adrien, Mellier, Joelle, Ménager, Philippe, Ménard, Céline, Mendes-Martin, Lucile, Menguy, Anne-Claude, Menouar, Mohamed, Merabet, Taoufik, Mercury, Paul, Meregnani, Corinne, Mérigot, Philippe, Mermont, Sylvain, Merrouche, Yacine, Merville, Pierre-Gilles, Mesnage, Renaud, Mesnard, Louis, Messager, Aurélie, Messiaen, Thierry, Messika, Jonathan, Messner Pellenc, Patrick, Métenier, Hervé, Metton, Pierre, Meyer, Christian, Mialon, Michel, Miatello, Jordi, Michaud-herbst, Alban, Michault, Alain, Micheli, Sophie, Michon, Jocelyn, Baptiste Michot, Jean, Mielczarek, Severine, Mignart, Sophie, Mignaut, Virginie, Migraine Bouvagnet, Audrey, Mihout, Fabrice, Mille, Catherine, Millet, Olivier, Milpied, Noel, Mimoz, Olivier, Minet, Jacques, Minguet, Bertrand, Mohty, Mohamad, Moiton, Marie-Pierre, Monarchi, Richard, Monceau, Yannick, Monchi, Mehran, Monlun, Eric, Monsegu, Jacques, Montagne, Nathalie, Montcriol, Ambroise, Montmasson, Bernard, Mootien, Paramasiven, Moquet, Olivier, Morando, Virginie, Moreau, Anne-Sohie, Morel, Yves, Morelon, Emmanuel, Morin-Fatome, Armelle, Morincomme, Mathieu, Morlat, Philippe, Mosser, Laurent, Motard-Picheloup, Annie, Mottaz, Philippe, Moulinoux, Claire, Mouly, Laurence, Mourad, Georges, Mouries, Jean-Claude, Moussa, Hecham, Moustache, Audrey, Muir, Jean-François, Murbach, Valérie, N'guyen, Yohann, N'guyen, Jean-Claude, N'guyen-Khac, Florence, Nabholtz, Jean-Marc, Naceur, Tarik, Nakhleh, Jean, Nare, Aline, Nassif, Xavier, Nathan-Bonnet, Frédérique, Negrery, Huguette, Negrier, Claude, Neri, Dominique, Nesrine, Hakima, Neuwirth, Catherine, Ngami, Eugène, Carole Ngo Bell, Elisabeth, Nicobaharaye, Dieudonné, Nicolet, Laurent, Nicolet, Laurence, Nicolino, Marc, Niel, Philippe, Nikodijevic, Karine, Nkunzimana, Jean-Marie, Noel, Christian, Noirot, Alain, Noto, Philippe, Noulard, Marie-Noelle, Ntalu Nkato, Christophe, Nyunga, Martine, Obiols, Julien, Ochocki, Patrick, Odent, Sylvie, Olivier, Brigitte, Oliviero, Gérard, Ondze, Basile, Orléva, Oléna, Orode, Paul, Osman, Henri, Oswald, Eric, Otean, Paola, Ouazir, Abderkader, Ozanon, Christophe, Paccalin, Marc, Pages, Marie-Christine, Paindaveine, Bénédicte, Pangon, Béatrice, Pannecouck, Jean-Marie, Paquet, Jean-Christophe, Parent, Sabrina, Parisi-Duchene, Elisabeth, Pasche, Jérôme, Pasdeloup, Thierry, Patin, David, Patrigeon, René-Gilles, Patry, Isabelle, Paul, Jean-Gabriel, Pavel, Simona, Pavic, Michel, Pawlotsky, Jean-Michel, Payan, Christopher, Payen, Christiane, Péan, Yves, Péchinot, Frédérique, Péchinot, André, Pecquet, Matthieu, Pélaquier, Agnès, Peltier, Hervé, Penn, Pascale, Pennaforte, Jean-Loup, Perez, Didier, Périsson, Caroline, Perotin, Dominique, Perouse de Montclos, Michèle, Perreve, Sophie, Perronne, Christian, Perrotin, Dominique, Pesque, Valerie, Pestel-Caron, Martine, Pestre, Vincent, Petassou, Fabrice, Petit, Marie-Cécile, Petit Hoang, Camille, Petitjean, Philippe, Pettinelli, François, Peultier, Anne-Sophie, Piala, Jean-Marie, Pialoux, Gilles, Piau, Caroline, Picard, Aurélia, Picaud, Jean-Charles, Pichard, Eric, Pierre, Martin, Pierre, Fabrice, Pierrot, Paul, Piet, Emilie, Piffaut, Marie-Claude, Pigeon, Bertrand, Pignon, Carole, Pinon, Georges, Piquet, Jacques, Piriou, Vincent, Placidi, Eric, Plainfosse, Gillles, Plane, Christophe, Plantier, Isabelle, Claudiu-Plesa, Nicolai, Plésiat, Patrick, Plessis, Patrick, Plouzeau-Jayle, Chloé, Ploy, Marie-Cécile, Pochmalicki, Gilbert, Pofelski, Joanna, Poinsignon, Yves, Poirier, Anne-Sophie, Poitevin, Françoise, Pommier, Christian, Ponceau, Bénédicte, Poncelet, Christophe, Pop, Daniela, Porcheron, Martine, Pordes, Réginald, Porthault, Eric, Portneuf, Marc, Pottier, Anne, Pouedras, Pascal, Poulain, Jocelyne, Poulain, Gérard, Poupet, Hélène, Pouyanne, Julien, Pouzoullic, Marie, Poyart, Claire, Pozzetto, Bruno, Prazuck, Thierry, Pressac, Dominique, Prévost, Fabrice, Prince, Sylvie, Priollet, Pascal, Proost, Olivier, Protar, Daniel, Pujade Lauraine, Eric, Pujol, Antoine, Puybasset, Louis, Puyhardy, Jean, Quentin, Vincent, Quinsat, Denis, Rabier, Valérie, Radaoui, Fouzia, Radenac, Florian, Radenne, Sylvie, Raffenot, Didier, Raffi, François, Rahmani, Hassène, Ramanantsoa, Céline, Ranchon, Guillaume, Ranta, Dana, Raoult, Didier, Rasigade, Jean-Philippe, Rassiat, Emmanuel, Raulin, Olivia, Ravaud, Alain, Ravet, Nathalie, Razafimahefa, Hasinrina, Razafimahery, Mirana, Re, Daniel, Real, Philippe, Rebattu, Paul, Rebeyrotte, Catherine, Reboul, Pascal, Reboux, Anne-Hélène, Recule, Christine, Redonnet, Jean-Philippe, Redor, Alexis, Regouby, Yves, Rémy, Claude, Renard, Gisèle, Renard, Benoît, Renou, Frédéric, Repellin, Philippe, Reveil, Jean-Claude, Revel, Valérie, Reverseau, Anne, Revest, Mathieu, Rey, Philippe, Rey, Hyacine, Rey Zermati, Jany, Reyes Ortega, Guillermo, Reynaud, Alain, Reynes, Jacques, Rezgui, Nasseur, Riahi, Jacques, Ribes, David, Ribier, Arnaud, Richard, Christian, Richardin, Florence, Riche, Agnès, Richette, Pascal, Ridah, Khalid, Riegel, Philippe, Riehl, Frédéric, Rigaux, Françoise, Rioux, Christophe, Rival, Gilles, Rivière, Brigitte, Robert, Henri, Robert, René, Robillard, Pierre-Yves, Roblin, Mélanie, Roblot, Pascal, Roblot, France, Rogeaux, Olivier, Roger, Pierre-Marie, Rohmer-Heitz, Dominique, Rolland, Christophe, Roncato-Saberane, Mariam, Ronda, Isabelle, Rondepierre, Philippe, Roque-Afonso, Anne-Marie, Rosay, David, Rose, Christian, Roseau, Jean-Baptiste, Rosello, Sophie, Rosselli, Sylvène, Rossignol, Serge, Rostaing, Lionel, Roth, Christian, Rothe, Marie-Rose, Roubert, Xavier, Rouget, Sébastien, Rouidi, Ahmed, Roulier, Philippe, Rouquet, Yannick, Rouquette-Vincent, Isabelle, Roure Sobas, Chantal, Rousseau, Sylvaine, Rousseau, Florence, Roussel, Etienne, Roussel, Jean-Christian, Roussel, Christophe, Roussellier, Patricia, Roy, Christophe, Royer, Daniel, Roze, Jean-Christophe, Rozec, Bertrand, Ruimy, Raymond, Ruppé, Etienne, Ruyer, Olivier, Sabbat, Sébastien, Saghi, Tahar, Saigne, Christophe, Sakek, Necera, Salama, Gilles, Salanoubat, Celia, Salaun-Beretta, Guenaelle, Saliba, Elie, Salles, Gilles, Salmon, Odile, Louis Salomon, Jean, Salord, Jean-Michel, Salvucci, Marina, Samson, Thierry, Sanchez, Richard, Sansot, Dominique, Saplacan, Mihaela, Saroufim, Carlo, Sauder, Philippe, Sautereau, Denis, Savare, Ferdinand, Savatier, Rim, Scemla, Anne, Schendel, Adeline, Schmitt, Anna, Schmitt, François, Schmitt, Alain, Schneerson, Morgane, Schneider, Francis, Schved, Jean-François, Schwebel, Carole, Sebban, Anthony, Secher, Aline, Sédillot, Nicholas, Sedjelmaci, Yacine, Segonds, Christine, Seignovert, Camille, Seknazi, Corinne, Semenescu, Marius, Sément, Arnaud, Semet, Jean-Claude, Semet, Guy, Sennevile, Eric, Serier, Miloud, Serre, Arnaud, Seta, Nathalie, Seyrig, Jacques-Arnaud, Sgro, Eric, Sibony-Prat, Joyce, Sicsic, Jean-Luc, Sifaoui, Farid, Signouret, Thomas, Sigur, Nicolas, Silhadi, Souad, Siméoni, Umberto, Simian, Bernard, Similowski, Thomas, Simon, Georges, Simon, François, Simonin, Catherine, Sirbu, Cristina, Sire, Jean-Marie, Sivadon-Tardy, Valérie, Sivery, Bruno, Slama, Michel, Smati, Salim, Sobesky, Rodolphe, Sokeng-Affoule, Hélène, Sollet, Jean-Pierre, Sommabère, André, Sondag, Daniel, Soraudeau, Florence, Sotto, Albert, Soulie, Bruno, Souply, Laurent, Souquet, Jean-Christophe, Soury, Pierre, Souweine, Bertrand, Stahl, Jean-Paul, Steibach, Marie-Isabelle, Stephan, Robin, Stoclin, Annabelle, Stolidi, Philippe, Strock, Paul, Suatean, Diana, Subra, Jean-François, Sucin, Yves, Suel, Philippe, Sullice, Marc, Szwebel, Tali-Anne, Tacchini, Laurent, Talabani-Boizot, Hana, Talarmin, Jean-Philippe, Taleb, Fethi, Tamalet, Catherine, Tamion, Fabienne, Tandonnet, Olivier, Tankovic, Jacques, Tardy, Véronique, Tassot, Christelle, Taurin, Gregory, Taylor, Sabine, Tchenio, Xavier, Tebib, Jacques, Teillet, Laurent, Teixeira, Antonio, Terki, Mustapha, Tesseydre, Sonia, Texier, Jean-Claude, Texier, Anthony, Thellier, Jean-Paul, Thibaud, Didier, Thibault, Michel, Thibaut, Freddy, Thierry, Jacques, Thoinet, Sylvie, Thomas, Pierre, Thomas, René, Thomas, Yves, Thomas, Caroline, Thore, Jean, Thouret, Jean-Marc, Thouvenin, Maxime, Thuet, Francis, Tigaizin, Ahmed, Tigaud, Sylvestre, Tiry, Catherine, Tissieres, Pierre, Tissot, Alain, Tixier, Anne, Touati, Kamel, Toubia, Marie-Lina, Toullalan, Olivier, Tourani, Jean-Marc, Tourrand, Bernadette, Touze, Yvan, Trabelsi-Jnifen, Asma, Traissac, Laurent, Anh Tran, Tu, Tran, Vanessa, Tricoire, Joelle, Tronchon, Laurent, Trouiller, Sébastien, Trystram, David, Ahmed, Becaid, Tsouria, Tuca, Mirela, Turpin, Mathilde, Vache, Bernard, Vachée, Anne, Vaillant, Christine, Valadier, Patrick, Valayer, Patrick, Valette, Xavier, Vallet, Françis, Van de Velde, Florence, Vanden Einjden, Serge, Vandenesch, François, Vande-perre, Philippe, Varin, Marie-Christine, Vary, Gwenaelle, Vaschalde, Yvan, Vassallo, Matteo, Vasse, Marc, Vasseur, Manica, Vatan, Rémi, Vaucel, Jacques, Vergnaud, Michel, Verhaeghe, Annick, Vermesch-Langlin, Annie, Vernet, Guy, Vernet Garnier, Véronique, Verrier, Virginie, Vessieres, Annie, Vialette, Véronique, Viard, Jean-Paul, Vieillard Baron, Antoine, Vighetto, Alain, Villemain, Marc, Villers, Daniel, Vilque, Jean-Pierre, Vinay, Agnès, Vincent, Didier, Vincent, Pascal, Vincent, Colette, Vincent, Simon, Vinci, Clara, Viole, Didier, Violette, Jérémie, Viquesnel, Gerard, Virlouvet, Anne-Laure, Visentin, Séverine, Vittecoq, Daniel, Vodovar, Dominique, Vrigneaud, Laurence, Vu-Thien, Hoang, Vuotto, Fanny, Wafo, Estelle, Wagner, Michel, Walid, Nicola, Walter, Elisabeth, Watson, Sarah, Weinbreck, Pierre, Weinbronn, Eva, Weiss, Emmanuel, Weitten, Thierry, Welker, Yves, Westeel, Pierre-François, Wink, Olivier, Wintenberger, Claire, Woerther, Paul-Louis, Worcel, Isabelle, Wuillai, Anne, Wurmser, Marc, Xavier, Jacob, Yazdanpanah, Yazdan, Yehia, Aihem, Yvenou, Sterenn, Zagdoun, Elie, Zagozda, Dominique, Zame, Thierry-Pascal, Zamfiri, Oana, Zanaldi, Hélène, Zandecki, Marc, Zaoui, Eric, Zarrouk, Virginie, Zarski, Jean-Pierre, Zavadil, Patrick, Zeller, Valérie, Zerbib, Franck, Zerr, Vincent, Zgarni, Lémia, Zoulim, Fabien, Zoveda, Patrick, Zuber, Pierre, Zumbo, Christian, Charlier, Caroline, Perrodeau, Élodie, Leclercq, Alexandre, Cazenave, Benoît, Pilmis, Benoît, Henry, Benoît, Lopes, Amanda, Maury, Mylène M, Moura, Alexandra, Goffinet, François, Dieye, Hélène Bracq, Thouvenot, Pierre, Ungeheuer, Marie-Noëlle, Tourdjman, Mathieu, Goulet, Véronique, de Valk, Henriette, Lortholary, Olivier, Ravaud, Philippe, and Lecuit, Marc

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2017
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