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3. Deferral of males who had sex with other males

Author

Benjamin, R. J., Bianco, C., Goldman, M., Seed, C. R., Yang, H., Lee, J., Keller, A. J., Wendel, S., Biagini, S., Murray, J., Devine, D. V., Zhu, Y., Turek, P., Moftah, F. M., Kullaste, R., Pillonel, J., Danic, B., Bigey, F., Folléa, G., Seifried, E., Mueller, M. M., Lin, C. K., Makroo, R. N., Grazzini, G., Pupella, S., Velati, C., Tadokoro, K., Lindoro, A. Bravo, González, A. DʼArtote, Giner, V. T., Flanagan, P., Olaussen, R. W., Letowska, M., Rosiek, A., Poglod, R., Zhiburt, E., Mali, P., Rozman, P., Gulube, S., Izaguirre, E. Castro, Ekermo, B., Barnes, S. M., McLaughlin, L., Eder, A. F., Panzer, S., and Reesink, H. W.

Published
2011
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5. Group O utilization patterns: The GROUP study.

Author

Ziman A., Weiland T., Wendel S., Heddle N.M., Yazer M.H., Zeller M., Aandahl A., Apelseth T., Callum J., Dunbar N.M., Garritsen H., Hancock H., Kutner J., Manukian B., Mizuta S., Okuda M., Pagano M.B., Poglod R., Rushford K., Selleng K., Sorensen C., Sprogoe U., Staves J., Van Wordragen M., Ziman A., Weiland T., Wendel S., Heddle N.M., Yazer M.H., Zeller M., Aandahl A., Apelseth T., Callum J., Dunbar N.M., Garritsen H., Hancock H., Kutner J., Manukian B., Mizuta S., Okuda M., Pagano M.B., Poglod R., Rushford K., Selleng K., Sorensen C., Sprogoe U., Staves J., and Van Wordragen M.

Abstract

Background/Case Studies: Group O red blood cells (RBCs) are the universal donor red cells; they can be given to a recipient with any other blood group. Although it is usually the standard practice to select ABO group specific blood as the first choice for patients requiring transfusion, there are many situations where group O blood is given to non-O recipients. Transfu-sion of group O blood to non-O recipients, or the transfusion of Rh negative (D-) blood to Rh positive (D1) recipients, can result in shortages of O or D-blood, respectively. Current patterns of group O and D- blood utilization are not well understood. Study Design/Methods: Hospital transfusion services collected ABO and Rh groups of transfused RBC units and of recipients during the 2013 calendar year. Units administered to recipients of unknown ABO or Rh group were excluded. Two analyses were performed: How often group O RBCs were transfused to non-O recipients, and how often D- units (of any ABO group) were transfused to D1 recipients. The hospitals were divided into 3 categories: Small (<250 beds), medium (250-1000 beds), and large (>1000 beds). Results/Findings: Data was received from 30 centers in 9 countries. There were 7 small, 17 medium and 6 large hospital respondents. In total, these 30 centers transfused a total of 415,696 RBC units, of which 2257 (0.5%) were units excluded from the D mismatch analysis because the D type of the recipient was unknown. The ABO groups of all recipients were known. Overall 11.1% of the O units were transfused to non-O recipients. The percentage of O RBCs transfused to non-O recipients was similar among the small, medium and large sized hospital respondents (12.4, 12.8 and 8.5%, respectively). The rate of group O RBC transfusion to non-O recipients at the small hospitals ranged from 0-33.0%, at the medium hospitals from 0-22.0%, and at the large hospitals from 5.0-10.0%. In terms of D- RBC transfusion to D1 recipients, overall 29.8% of the D- units were transfus

Published
2017

6. An international investigation into O red blood cell unit administration in hospitals: the GRoup O Utilization Patterns (GROUP) study.

Author

Heddle N.M., van Wordragen-Vlaswinkel M., Ziman A., Jan Zwaginga J., Murphy M.F., Yazer M.H., Zeller M.P., Barty R., Aandahl A., Apelseth T.O., Callum J., Dunbar N.M., Elahie A., Garritsen H., Hancock H., Kutner J.M., Manukian B., Mizuta S., Okuda M., Pagano M.B., Poglod R., Rushford K., Selleng K., Sorensen C.H., Sprogoe U., Staves J., Weiland T., Wendel S., Wood E.M., van de Watering L., Heddle N.M., van Wordragen-Vlaswinkel M., Ziman A., Jan Zwaginga J., Murphy M.F., Yazer M.H., Zeller M.P., Barty R., Aandahl A., Apelseth T.O., Callum J., Dunbar N.M., Elahie A., Garritsen H., Hancock H., Kutner J.M., Manukian B., Mizuta S., Okuda M., Pagano M.B., Poglod R., Rushford K., Selleng K., Sorensen C.H., Sprogoe U., Staves J., Weiland T., Wendel S., Wood E.M., and van de Watering L.

Abstract

BACKGROUND: Transfusion of group O blood to non-O recipients, or transfusion of D- blood to D+ recipients, can result in shortages of group O or D- blood, respectively. This study investigated RBC utilization patterns at hospitals around the world and explored the context and policies that guide ABO blood group and D type selection practices. STUDY DESIGN AND METHODS: This was a retrospective study on transfusion data from the 2013 calendar year. This study included a survey component that asked about hospital RBC selection and transfusion practices and a data collection component where participants submitted information on RBC unit disposition including blood group and D type of unit and recipient. Units administered to recipients of unknown ABO or D group were excluded. RESULT(S): Thirty-eight hospitals in 11 countries responded to the survey, 30 of which provided specific RBC unit disposition data. Overall, 11.1% (21,235/191,397) of group O units were transfused to non-O recipients; 22.6% (8777/38,911) of group O D- RBC units were transfused to O D+ recipients, and 43.2% (16,800/38,911) of group O D- RBC units were transfused to recipients that were not group O D-. Disposition of units and hospital transfusion policy varied within and across hospitals of different sizes, with transfusion of group O D- units to non-group O D- patients ranging from 0% to 33%. CONCLUSION(S): A significant proportion of group O and D- RBC units were transfused to compatible, nonidentical recipients, although the frequency of this practice varied across sites.Copyright © 2017 AABB

Published
2017

7. Development of RBC transfusion indications and the collection of patient-specific pre-transfusion information.

Author

Lin Y., Okazaki H., Ikeda T., Nagura Y., Zwaginga J.J., Poglod R., Rosiek A., Letowska M., Yuen J., Cid J., Harm S.K., Adhikari P., Yazer M.H., van de Watering L., Lozano M., Sirdesai S., Rushford K., Wood E.M., Yokoyama A.P., Kutner J.M., Callum J., Cserti-Gazdewich C., Lieberman L., Pendergrast J., Pendry K., Murphy M.F., Selleng K., Greinacher A., Marwaha N., Sharma R., Jain A., Orlin Y., Yahalom V., Perseghin P., Incontri A., Masera N., Lin Y., Okazaki H., Ikeda T., Nagura Y., Zwaginga J.J., Poglod R., Rosiek A., Letowska M., Yuen J., Cid J., Harm S.K., Adhikari P., Yazer M.H., van de Watering L., Lozano M., Sirdesai S., Rushford K., Wood E.M., Yokoyama A.P., Kutner J.M., Callum J., Cserti-Gazdewich C., Lieberman L., Pendergrast J., Pendry K., Murphy M.F., Selleng K., Greinacher A., Marwaha N., Sharma R., Jain A., Orlin Y., Yahalom V., Perseghin P., Incontri A., and Masera N.

Published
2017

8. How Many AB Plasma Units Were Infused? The HABSWIN Study

Author

Zeller, M., Barty, R.L., Elahie, A., Dunbar, N.M., Flanagan, P., Garritsen, H., Kutner, J., Pagano, M.B., Poglod, R., Rogers, T.S., Staves, J., Wordragen, M. van, Zwaginga, J., Heddle, N.M., Yazer, M.H., and O Collaborative

Published
2016

9. Deferral of males who had sex with other males

Author

Benjamin, R J, Bianco, C, Seed, C R, Yang, H, Lee, J, Keller, A J, Wendel, S, Biagini, S, Murray, J, Turek, P, Moftah, F M, Kullaste, R, Pillonel, J, Danic, B, Bigey, F, Follea, G, Seifried, E, M Mueller, M, Lin, C K, Makroo, R N, Grazzini, G, Pupella, S, Velati, C, Tadokoro, K, Bravo Lindoro, A, DArtote Gonzalez, A, Giner, V T, Flanagan, P, Olaussen, R W, Letowska, M, Rosiek, A, Poglod, R, Zhiburt, E, Mali, P, Rozman, P, Gulube, S, Castro Izaguirre, E, Ekermo, Bengt, Barnes, S M, McLaughlin, L, Reesink, H W, Benjamin, R J, Bianco, C, Seed, C R, Yang, H, Lee, J, Keller, A J, Wendel, S, Biagini, S, Murray, J, Turek, P, Moftah, F M, Kullaste, R, Pillonel, J, Danic, B, Bigey, F, Follea, G, Seifried, E, M Mueller, M, Lin, C K, Makroo, R N, Grazzini, G, Pupella, S, Velati, C, Tadokoro, K, Bravo Lindoro, A, DArtote Gonzalez, A, Giner, V T, Flanagan, P, Olaussen, R W, Letowska, M, Rosiek, A, Poglod, R, Zhiburt, E, Mali, P, Rozman, P, Gulube, S, Castro Izaguirre, E, Ekermo, Bengt, Barnes, S M, McLaughlin, L, and Reesink, H W

Abstract

n/a

Published
2011
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23. Deferral of males who had sex with other males

Author

Benjamin, R. J., Bianco, C., Goldman, M., Clive Seed, Yang, H., Lee, J., Keller, A. J., Wendel, S., Biagini, S., Murray, J., Devine, D. V., Zhu, Y., Turek, P., Moftah, F. M., Kullaste, R., Pillonel, J., Danic, B., Bigey, F., Folléa, G., Seifried, E., Mueller, M. M., Lin, C. K., Makroo, R. N., Grazzini, G., Pupella, S., Velati, C., Tadokoro, K., Bravo Lindoro, A., D Artote González, A., Giner, V. T., Flanagan, P., Olaussen, R. W., Letowska, M., Rosiek, A., Poglod, R., Zhiburt, E., Mali, P., Rozman, P., Gulube, S., Castro Izaguirre, E., Ekermo, B., Barnes, S. M., Mclaughlin, L., Eder, A. F., Panzer, S., Reesink, H. W., and Gastroenterology and Hepatology

Subjects
Male, Surveys and Questionnaires, Humans, Transfusion Reaction, Blood Donors, HIV Infections, Homosexuality, Male

25. The Crossmatch/Issue Ratio:  Use of a Novel Quality Indicator and Results of an International Survey on RBC Crossmatching and Issuing Practices.

Author

Yazer MH, Alcantara R, Beizai P, Draper NL, Harm SK, Kutner JM, Lin D, Poglod R, Rogers TS, Sørensen CH, Sprogøe U, Welbig J, Yuen J, and Ziman A

Subjects
Humans, Quality Assurance, Health Care, Surveys and Questionnaires, Blood Grouping and Crossmatching methods, Erythrocyte Transfusion, Medical Records Systems, Computerized
Abstract

Objectives: To understand the worldwide scope of RBC crossmatching and issuing practices and measure efficiency using a novel quality indicator, the crossmatch/issue (C/I) ratio., Methods: An electronic survey was disseminated to hospital transfusion services collecting details about RBC crossmatching and issuing practices. Respondents were asked to enumerate the number of RBCs crossmatched and issued at their institutions during the 2014 calendar year to calculate the C/I ratio., Results: Fifty-two survey responses were received, mostly from North American transfusion services (28/52, 54%). The electronic crossmatch was the most common technique (n = 29), and most respondents performed the crossmatch at the time that an order for RBCs was received in the transfusion service (even if an order to issue the RBCs was not received). Data to calculate the C/I ratio were supplied by 22 respondents, and the mean ± SD was 1.30 ± 0.34. There was no difference in C/I ratios between services that use the electronic or serologic crossmatch techniques (P = .49). The ratio was the same at the four sites that crossmatch RBCs at the time of issue compared with the time of order receipt (mean ± SD, 1.11 ± 0.09 vs. 1.35 ± 0.36, respectively; P = .19)., Conclusions: Electronic crossmatching is common, and the C/I ratio can be an indicator of efficiency., (© American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2016
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26. Separation of normal human erythrocyte membrane proteins by high resolution two-dimensional gel electrophoresis.

Author

Heegaard NH and Poglod R

Subjects
Densitometry, Humans, Hydrolysis, Image Processing, Computer-Assisted, Membrane Proteins isolation & purification, Molecular Weight, Reproducibility of Results, Silver Staining, Solubility, Blood Proteins isolation & purification, Electrophoresis, Gel, Two-Dimensional, Erythrocyte Membrane chemistry, Membrane Proteins blood
Abstract

Different factors influencing two-dimensional gel electrophoresis of red cell membrane proteins were studied: membrane preparation and sample solubilization with a special regard to proteolytic artifacts, urea addition, slab gel acrylamide concentrations and silver staining methods. Spot patterns were analyzed both visually and by means of computer-assisted densitometry. A resolution of around 450 spots was achieved on 10% acrylamide slab gels. The reproducibility of the whole two-dimensional gel electrophoresis procedure was assessed by analysis of computer generated spot densities on gels which were run simultaneously with the same sample. It was shown that the standard red cell membrane preparation method does not lead to proteolysis, contamination by cytosolic proteins, or proteins from other cell types. In comparison with previous studies the relatively high resolution seemed to be due to a high solubilization efficiency combined with the use of a sensitive silver staining method.

Published
1991

27. Abnormal protein in the cerebrospinal fluid of patients with a submicroscopic X-chromosomal deletion associated with Norrie disease: preliminary report.

Author

Joy JE, Poglod R, Murphy DL, Sims KB, de la Chapelle A, Sankila EM, Norio R, and Merril CR

Subjects
Blindness congenital, Blindness genetics, Cerebrospinal Fluid Proteins genetics, Electrophoresis, Gel, Two-Dimensional, Humans, Intellectual Disability cerebrospinal fluid, Intellectual Disability genetics, Male, Monoamine Oxidase deficiency, Blindness cerebrospinal fluid, Cerebrospinal Fluid Proteins isolation & purification, Chromosome Deletion, X Chromosome
Abstract

Norrie disease is an X-linked recessive disorder characterized by congenital blindness and, in many cases, mental retardation. Some Norrie disease cases have been shown to be associated with a submicroscopic deletion in chromosomal region Xp11.3. Cerebrospinal fluid (CSF) was collected from four male patients with an X-chromosomal deletion associated with Norrie disease. CSF proteins were resolved using two-dimensional gel electrophoresis and then analyzed by computer using the Elsie V program. Our analysis revealed a protein that appears to be altered in patients with Norrie disease deletion.

Published
1991

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