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35 results on '"Podio, Valerio"'

13. Assessing the accuracy and reproducibility of computer-assisted analysis of (123) I-FP-CIT SPECT using BasGan (V2)

Author

Skanjeti, A., Angusti, T., Iudicello, M., Dazzara, F., Delgado Yabar, G. M., Trevisiol, E., and Podio, Valerio

Subjects
Male, Observer Variation, Tomography, Emission-Computed, Single-Photon, Software Validation, Brain, Reproducibility of Results, Parkinson Disease, Image Enhancement, Sensitivity and Specificity, Imaging, Three-Dimensional, Image Interpretation, Computer-Assisted, Humans, Female, Radiopharmaceuticals, Algorithms, Software, Aged, Tropanes
Abstract

Over the last two decades (123) I-FP-CIT-SPECT, has been used to discriminate neurodegenerative Parkinsonian syndrome from other diseases. BasGan is a freely available software that assists (123) I-FP-CIT-SPECT evaluation by estimating semiquantitative values for each basal nucleus and compares the results to a database of healthy subjects. The aims of this study were: (1) to assess the accuracy of qualitative analysis and of semiquantitative, BasGan-assisted evaluations of (123) I-FP-CIT-SPECT; (2) to compare the accuracy of both methods when applied to "doubtful" cases; (3) to appreciate the reproducibility of the BasGan-assisted evaluations.Seventy-eight patients were included in this 4-year follow-up study. The diagnostic cut-off for semiquantitative uptake values of each basal nucleus was determined based on ROC curves analysis. Accuracy scores were calculated for the entire population and for "doubtful" cases. Intra- and interoperator reproducibility was assessed.Accuracy of the software-assisted analyses was high for data from each nucleus. In "doubtful" exams accuracy was higher when using BasGan as opposed to relying solely on visual assessment. Intra- and interoperator reproducibility of the BasGan-assisted evaluations was good to excellent.BasGan-assisted evaluations of (123) I-FP-CIT-SPECT were very useful, particularly in "doubtful" cases. Multicenter studies are mandatory before routine use of BasGan.

Published
2012

15. Multicenter Semiquantitative Evaluation of 123 I-FP-CIT Brain SPECT

Author

Skanjeti, Andrea, primary, Castellano, Giancarlo, additional, Elia, Baldassarre O., additional, Zotta, Michela, additional, Dazzara, Francesca, additional, Manfredi, Matteo, additional, Galati, Antonello, additional, Grimaldi, Serena, additional, Balma, Michele, additional, Pellerito, Riccardo E., additional, and Podio, Valerio, additional

Published
2015
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21. Standardized Semi-Quantitative Evaluation of [123I]FP-CIT SPECT in a Multicenter Study

Author

Skanjeti, Andrea, primary, Castellano, Giancarlo, additional, Elia, Baldassarre, additional, Dazzara, Francesca, additional, Zotta, Michela, additional, Mariam Delgado Yabar, Gabriela, additional, Manfredi, Matteo, additional, Iudicello, Marco, additional, Zibetti, Maurizio, additional, Ferrero, Patrizia, additional, Filippi, Paola, additional, Emanuele Pellerito, Riccardo, additional, and Podio, Valerio, additional

Published
2013
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25. 99mTc-MIBI Imaging in the Presurgical Characterization of Thyroid Follicular Neoplasms: Relationship to Multidrug Resistance Protein Expression

Author

Saggiorato, Enrico, primary, Angusti, Tiziana, additional, Rosas, Rosy, additional, Martinese, Morena, additional, Finessi, Monica, additional, Arecco, Federico, additional, Trevisiol, Edoardo, additional, Bergero, Nicoletta, additional, Puligheddu, Barbara, additional, Volante, Marco, additional, Podio, Valerio, additional, Papotti, Mauro, additional, and Orlandi, Fabio, additional

Published
2009
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29. The Role of Cortex in Central Pain Syndromes

Author

Canavero, Sergio, primary, Pagni, Carlo Alberto, additional, Castellano, Giancarlo, additional, Bonicalzi, Vincenzo, additional, Bello??, Marilena, additional, Duca, Sergio, additional, and Podio, Valerio, additional

Published
1993
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31. In Vitro and In Vivo Study of Solid Lipid Nanoparticles Loaded with Superparamagnetic Iron Oxide.

Author

Peira, Elena, Marzola, Pasquina, Podio, Valerio, Aime, Silvio, Sbarbati, Andrea, and Gasco, Maria Rosa

Subjects
LIPIDS, BIOMOLECULES, IRON oxides, METALLIC oxides, MAGNETIC resonance imaging
Abstract

Solid Lipid Nanoparticles (SLN) are already under investigation as a pharmaceutical tool able to change the pharmacokinetic and biodistribution of carried molecules. SLN are able to target drugs to lymph after duodenal administration and to overcome the Blood Brain Barrier (BBB). In this study, superparamagnetic SLN have been prepared, have colloidal size, in vitro analysis showed relaxometric properties similar to Endorem ® . In vivo Magnetic Resonance Imaging (MRI) of the central nervous system (CNS) with both SLN and Endorem ® showed that superparamagnetic SLN have slower blood clearance than Endorem ® . MRI data are consistent with CNS uptake of SLN lasting up to the end of the experiment (135 min). These findings confirm the ability of SLN to overcome the BBB; SLN might be used as a CNS MRI contrast agent. [ABSTRACT FROM AUTHOR]

Published
2003
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33. Dynamic renal scanning using Tc-MAG-3 in man.

Author

Maini, Carlo, Antonacci, Paolo, Sargiotto, Antonella, Castellano, Giancarlo, and Podio, Valerio

Abstract

Tc-labelled mercapto-acetyltriglycine (MAG-3) has recently been proposed as an ortho-iodohippurate (OIH) substitute for dynamic renal imaging. Experience with MAG-3 is, however, still limited and its biokinetics are not completely known. Moreover, most of the published studies have used HPLC purified MAG-3 which is inpractical for routine clinical work. In this study a commercially available kit of MAG-3 which does not require high performance liquid chromatography (HPLC) is used in 10 normal subjects and 15 patients with renal disease. The results obtained lead to the following conclusions: [ABSTRACT FROM AUTHOR]

Published
1989
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34. Dynamic renal scanning using 99mTc-MAG-3 in man

Author

Maini, Carlo Ludovico, Antonacci, Paolo, Sargiotto, Antonella, Castellano, Giancarlo, and Podio, Valerio

Abstract

99mTc-labelled mercapto-acetyltriglycine (MAG-3) has recently been proposed as an ortho-iodohippurate (OIH) substitute for dynamic renal imaging. Experience with MAG-3 is, however, still limited and its biokinetics are not completely known. Moreover, most of the published studies have used HPLC purified MAG-3 which is inpractical for routine clinical work. In this study a commercially available kit of MAG-3 which does not require high performance liquid chromatography (HPLC) is used in 10 normal subjects and 15 patients with renal disease. The results obtained lead to the following conclusions:a.MAG-3 provided in kit form is suitable for renal imaging and semiquantitative analysis in routine clinical settings.b.There are significant differences between renal handling of MAG-3 and OIH, but the dynamic studies obtained with MAG-3 can be interpreted with the same criteria used for OIH studies.c.More information on MAG-3 kinetics is needed before this new radiopharmaceutical can be considered as an OIH substitute for truly quantitative studies such as effective renal plasma flow determinations.

Published
1989
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35. Re: Evaluation of Functional Outcomes after Laparoscopic Partial Nephrectomy Using Renal Scintigraphy: Clamped vs Clampless Technique.

Author

Porpiglia, Francesco, Bertolo, Riccardo, Amparore, Daniele, Fiori, Cristian, Podio, Valerio, Angusti, Tiziana, and Veltri, Andrea

Subjects
NEPHRECTOMY, KIDNEY tumors, TUMOR treatment
Abstract

The article compares the functional outcomes for the off-clamp and on-clamp minimal invasive partial nephrectomy techniques for kidney tumor patients using renal scintigraphy.

Published
2015
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