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Byline: Shreya. Poddar, Anupam. Das, Roderick. Hay, Uwe. Wollina With the advent of newer drugs and formulations, the armamentarium to combat dermatophytosis is ever-expanding. However, we must be rational and [...]

Neuropathic itch is a relatively common yet under-reported cause of systemic pruritus. It is a debilitating condition often associated with pain, which impairs the patient's quality of life. Although much literature exists about renal and hepatic pruritus, there is a dearth of information and awareness about neuropathic itch. The pathogenesis of neuropathic itch is complex and can result from an insult at any point along the itch pathway, ranging from the peripheral receptors and nerves until the brain. There are several causes of neuropathic itch, many of which do not produce any skin lesions and are thus, often missed. A detailed history and clinical examination are necessary for the diagnosis, while laboratory and radiologic investigations may be needed in select cases. Several therapeutic strategies currently exist involving both non-pharmacological and pharmacological measures, the latter including topical, systemic, and invasive options. Further research is ongoing to clarify its pathogenesis and to design newer targeted therapies with minimal adverse effects. This narrative review highlights the current understanding of this condition, focusing on its causes, pathogenesis, diagnosis, and management, along with newer investigational drugs. [ABSTRACT FROM AUTHOR]

Byline: Gourab. Roy, Sumit. Sen, Shreya. Poddar Acanthosis nigricans (AN) describes clinically hyperpigmented skin, which most commonly affects the flexural areas such as axilla, groin and neck. It is usually [...]

This article discusses a case of tongue angioedema caused by the medication vildagliptin, which is an oral antidiabetic agent. While angioedema is a known side effect of certain medications, such as ACE inhibitors, this case is unique because the patient did not have any concurrent use of ACE inhibitors. The patient experienced sudden-onset tongue swelling, which resolved after discontinuing vildagliptin and switching to a different medication. The article emphasizes the importance of recognizing and discontinuing the offending drug in cases of angioedema, even if it is not a commonly associated medication. [Extracted from the article]

Wolf isotopic response is the occurrence of new dermatoses on areas of the skin with previous but still active dermatoses. Vitiligo is an acquired disorder characterized by the loss of functional melanocytes which manifests as circumscribed depigmented macules and patches. Dermatophytoses are superficial fungal infections caused by three genera of fungi (Microsporum, Trichophyton, and Epidermophyton) that have the unique ability to invade and multiply within keratinized tissue (skin, hair, and nail). The appearance of dermatophyte infection on previously present vitiligo lesion is an uncommon example of Wolf response. We describe a case series of five vitiligo patients that presented to our OPD over 1 year period. [ABSTRACT FROM AUTHOR]

A case study reports an uncommon adverse effect of azathioprine, causing anagen effluvium in an adolescent girl with cutaneous small vessel vasculitis. This condition led to hair loss, resolved within two months post-azathioprine cessation, underscoring the importance of recognizing this rare adverse reaction of a commonly used drug.

A case study presents a 55-year-old woman with generalized hyperpigmentation diagnosed as Acanthosis Nigricans (AN) coexisting with Lichen Planus Pigmentosus (LPP), a unique association. Despite the common link of generalised AN with malignancy, this case showed no evidence of internal malignancy, highlighting the rarity of such benign presentations.