Search

Your search keyword '"Podbregar, Matej"' showing total 269 results
Start Over Author "Podbregar, Matej"
269 results on '"Podbregar, Matej"'

1. Landiolol for heart rate control in patients with septic shock and persistent tachycardia. A multicenter randomized clinical trial (Landi-SEP)

Author

Rehberg, Sebastian, Frank, Sandra, Černý, Vladimír, Cihlář, Radek, Borgstedt, Rainer, Biancofiore, Gianni, Guarracino, Fabio, Schober, Andreas, Trimmel, Helmut, Pernerstorfer, Thomas, Siebers, Christian, Dostál, Pavel, Morelli, Andrea, Joannidis, Michael, Pretsch, Ingrid, Fuchs, Christian, Rahmel, Tim, Podbregar, Matej, Duliczki, Éva, Tamme, Kadri, Unger, Martin, Sus, Jan, Klade, Christoph, Krejcy, Kurt, Kirchbaumer-Baroian, Nairi, Krumpl, Günther, and Duška, František

Published
2024
Full Text
View/download PDF

7. Functional Magnetic Neuromuscular Stimulation vs. Routine Physiotherapy in the Critically Ill for Prevention of ICU Acquired Muscle Loss: A Randomised Controlled Trial.

Author

Skočir, Anej, Jevšnik, Alja, Plaskan, Lidija, and Podbregar, Matej

Subjects
ELECTRIC stimulation, QUADRICEPS muscle, SKELETAL muscle, RANDOMIZED controlled trials, SKIN injuries
Abstract

Background and Objectives: Muscle loss is a known complication of ICU admission. The aim of the study was to investigate the effect of neuromuscular functional magnetic stimulation (FMS) on quadriceps muscle thickness in critically ill patients. Materials and Methods: Among ICU patients one quadriceps was randomized to FMS (Tesla Stym, Iskra Medical, Ljubljana, Slovenia) stimulation and the other to control care. Quadriceps thickness was measured by ultrasound (US) in transversal and longitudinal planes at enrolment, Days 3–5, and Days 9–12. The trial stopped early following an interim analysis comparing muscle thickness differences between groups using repeated measures ANOVA. Results: Of 18 patients randomized, 2 died before completing the trial. The final analysis reported included 16 patients (female 38%, age 68 ± 10 years, SOFA 10.8 ± 2.7). Three mild skin thermal injuries were noted initially, which were later avoided with proper positioning of FMS probe. Primary outcome comparison showed that quadriceps thickness in transversal and longitudinal planes decreased in the non-stimulated legs and, but it did not change in FMS legs (−4.1 mm (95%CI: −9.4 to −0.6) vs. −0.7 mm (95%CI: −4.1 to −0.7) (p = 0.03) and −4.4 mm (95%CI: −8.9 to −1.1) vs. −1.5 mm (95%CI: −2.6 to −2.2) (p = 0.02), respectively) (ANOVA difference between groups p = 0.036 and 0.01, respectively). Conclusions: In the critically ill, neuromuscular FMS is feasible and safe with precautions applied to avoid possible skin thermal injury. FMS decreases the loss of quadriceps muscle thickness. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. SepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units

Author

Benes, Jan, Jankowski, Miłosz, Szułdrzynski, Konstanty, Zahorec, Roman, Lainscak, Mitja, Ruszkai, Zoltán, Podbregar, Matej, Zatloukal, Jan, Kletecka, Jakub, Kusza, Krzysztof, Szrama, Jakub, Ramic, Estera, Galkova, Katarina, Krbila, Stefan, Valky, Josef, Ivanic, Jaka, Kurnik, Marko, Mikó, Angéla, Kiss, Tamás, Hetényi, Barbara, Hegyi, Peter, Sustic, Alan, and Molnar, Zsolt

Published
2022
Full Text
View/download PDF

9. Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial

Author

Barth, Eberhard, Becher, Tobias, Bein, Berthold, Bellgardt, Martin, Biever, Paul, Bogdanski, Ralph, Bracht, Hendrik, Brandt, Sebastian, Drüner, Matthias, Faltlhauser, Anreas, Geise, Arnim, Georgevici, Adrian Iustin, Gude, Philipp, Guenther, Ulf, Hamsen, Uwe, Hönemann, Christian, Kellner, Patrick, Kellner, Kerstin, Kermad, Azzeddine, Knafelj, Rihard, Kogelmann, Klaus, Kram, Rainer, Markota, Andrej, Meermeier, Werner, Meiser, Andreas, Podbregar, Matej, Sackey, Peter, Schramm, Patrick, Schroeder, Matthias, Schwarzkopf, Konrad, Soukup, Jens, Thal, Serge C, Vogelsang, Heike, Volk, Thomas, Wallenborn, Jan, Waydhas, Christian, Weiler, Norbert, Wetzold, Richard, and Faltlhauser, Andreas

Published
2021
Full Text
View/download PDF

10. Landiolol for heart rate control in patients with septic shock and persistent tachycardia A multicenter Randomized Clinical Trial (Landi-SEP)

Author

Rehberg, Sebastian, primary, Frank, Sandra, additional, Černý, Vladimír, additional, Cihlář, Radek, additional, Borgstedt, Rainer, additional, Biancofiore, Gíanni, additional, Guarracino, Fabio, additional, Schober, Andreas, additional, Trimmel, Helmut, additional, Pernerstorfer, Thomas, additional, Siebers, Christian, additional, Dostál, Pavel, additional, Morelli, Andrea, additional, Joannidis, Michael, additional, Pretsch, Ingrid, additional, Fuchs, Christian, additional, Rahmel, Tim, additional, Podbregar, Matej, additional, Duliczki, Éva, additional, Tamme, Kadri, additional, Unger, Martin, additional, Sus, Jan, additional, Klade, Christoph, additional, Kirchbaumer-Baroian, Nairi, additional, Krejcy, Kurt, additional, Krumpl, Günther, additional, and Duška, František, additional

Published
2024
Full Text
View/download PDF

18. Red Blood Cell Transfusion in the Intensive Care Unit

Author

Raasveld, Senta Jorinde, De Bruin, Sanne, Reuland, Merijn C., Van Den Oord, Claudia, Schenk, Jimmy, Aubron, Cécile, Bakker, Jan, Cecconi, Maurizio, Feldheiser, Aarne, Meier, Jens, Müller, Marcella C.A., Scheeren, Thomas W.L., McQuilten, Zoe, Flint, Andrew, Hamid, Tarikul, Piagnerelli, Michaël, Tomić Mahečić, Tina, Benes, Jan, Russell, Lene, Aguirre-Bermeo, Hernan, Triantafyllopoulou, Konstantina, Chantziara, Vasiliki, Gurjar, Mohan, Myatra, Sheila Nainan, Pota, Vincenzo, Elhadi, Muhammed, Gawda, Ryszard, Mourisco, Mafalda, Lance, Marcus, Neskovic, Vojislava, Podbregar, Matej, Llau, Juan V., Quintana-Diaz, Manual, Cronhjort, Maria, Pfortmueller, Carmen A., Yapici, Nihan, Nielsen, Nathan D., Shah, Akshay, De Grooth, Harm Jan, Vlaar, Alexander P.J., Raasveld, Senta Jorinde, De Bruin, Sanne, Reuland, Merijn C., Van Den Oord, Claudia, Schenk, Jimmy, Aubron, Cécile, Bakker, Jan, Cecconi, Maurizio, Feldheiser, Aarne, Meier, Jens, Müller, Marcella C.A., Scheeren, Thomas W.L., McQuilten, Zoe, Flint, Andrew, Hamid, Tarikul, Piagnerelli, Michaël, Tomić Mahečić, Tina, Benes, Jan, Russell, Lene, Aguirre-Bermeo, Hernan, Triantafyllopoulou, Konstantina, Chantziara, Vasiliki, Gurjar, Mohan, Myatra, Sheila Nainan, Pota, Vincenzo, Elhadi, Muhammed, Gawda, Ryszard, Mourisco, Mafalda, Lance, Marcus, Neskovic, Vojislava, Podbregar, Matej, Llau, Juan V., Quintana-Diaz, Manual, Cronhjort, Maria, Pfortmueller, Carmen A., Yapici, Nihan, Nielsen, Nathan D., Shah, Akshay, De Grooth, Harm Jan, and Vlaar, Alexander P.J.

Abstract

Importance: Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little is known about how these thresholds are incorporated into current practice. Objective: To evaluate and describe ICU RBC transfusion practices worldwide. Design, Setting, and Participants: International, prospective, cohort study that involved 3643 adult patients from 233 ICUs in 30 countries on 6 continents from March 2019 to October 2022 with data collection in prespecified weeks. Exposure: ICU stay. Main Outcomes and Measures: The primary outcome was the occurrence of RBC transfusion during ICU stay. Additional outcomes included the indication(s) for RBC transfusion (consisting of clinical reasons and physiological triggers), the stated Hb threshold and actual measured Hb values before and after an RBC transfusion, and the number of units transfused. Results: Among 3908 potentially eligible patients, 3643 were included across 233 ICUs (median of 11 patients per ICU [IQR, 5-20]) in 30 countries on 6 continents. Among the participants, the mean (SD) age was 61 (16) years, 62% were male (2267/3643), and the median Sequential Organ Failure Assessment score was 3.2 (IQR, 1.5-6.0). A total of 894 patients (25%) received 1 or more RBC transfusions during their ICU stay, with a median total of 2 units per patient (IQR, 1-4). The proportion of patients who received a transfusion ranged from 0% to 100% across centers, from 0% to 80% across countries, and from 19% to 45% across continents. Among the patients who received a transfusion, a total of 1727 RBC transfusions were administered, wherein the most common clinical indications were low Hb value (n = 1412 [81.8%]; mean [SD] lowest Hb before transfusion, 7.4 [1.2] g/dL), active bleeding (n = 479; 27.7%), and hemodynamic instability (n = 406 [23.5%]). Among the events with a stated physiological trigger, the most

Published
2023

19. Red blood cell transfusion and skeletal muscle tissue oxygenation in anaemic haematologic outpatients

Author

Podbregar Matej, Gavric Ana Ursula, Podbregar Eva, Mozina Hugon, and Stefanovic Sebastian

Subjects
skeletal muscle, tissue oxygenation, red blood cells, transfusion, storage lesion, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy.

Published
2016
Full Text
View/download PDF

27. Results of the SepsEast Registry to define the Characteristics in Coronavirus Disease in Central-Eastern Europe between March 2020-February 2021: an international, multicentre retrospective study of the SEARCH-COVID-19 Study Group

Author

Benes, Jan, primary, Jankowski, Miłosz, additional, Szułdrzynski, Konstanty, additional, Zahorec, Roman, additional, Lainscak, Mitja, additional, Ruszkai, Zoltán, additional, Podbregar, Matej, additional, Zatloukal, Jan, additional, Kletecka, Jakub, additional, Kusza, Krzysztof, additional, Szrama, Jakub, additional, Ramic, Estera, additional, Galkova, Katarina, additional, Krbila, Stefan, additional, Valky, Josef, additional, Ivanic, Jaka, additional, Kurnik, Marko, additional, Mikó, Angéla, additional, Kiss, Tamás, additional, Hetényi, Barbara, additional, Hegyi, Peter, additional, Sustic, Alan, additional, and Molnar, Zsolt, additional

Published
2022
Full Text
View/download PDF

30. Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial

Author

Meiser, Andreas, primary, Volk, Thomas, additional, Wallenborn, Jan, additional, Guenther, Ulf, additional, Becher, Tobias, additional, Bracht, Hendrik, additional, Schwarzkopf, Konrad, additional, Knafelj, Rihard, additional, Faltlhauser, Andreas, additional, Thal, Serge C, additional, Soukup, Jens, additional, Kellner, Patrick, additional, Drüner, Matthias, additional, Vogelsang, Heike, additional, Bellgardt, Martin, additional, Sackey, Peter, additional, Barth, Eberhard, additional, Bein, Berthold, additional, Biever, Paul, additional, Bogdanski, Ralph, additional, Brandt, Sebastian, additional, Faltlhauser, Anreas, additional, Geise, Arnim, additional, Georgevici, Adrian Iustin, additional, Gude, Philipp, additional, Hamsen, Uwe, additional, Hönemann, Christian, additional, Kellner, Kerstin, additional, Kermad, Azzeddine, additional, Kogelmann, Klaus, additional, Kram, Rainer, additional, Markota, Andrej, additional, Meermeier, Werner, additional, Meiser, Andreas, additional, Podbregar, Matej, additional, Schramm, Patrick, additional, Schroeder, Matthias, additional, Waydhas, Christian, additional, Weiler, Norbert, additional, and Wetzold, Richard, additional

Published
2021
Full Text
View/download PDF

32. Additional file 1 of Cerebral microemboli in mini-sternotomy compared to mini- thoracotomy for aortic valve replacement: a cross sectional cohort study

Author

Bozhinovska, Marija, Jenko, Matej, Stupica, Gordana Taleska, Klokočovnik, Tomislav, Juš Kšela, Jelenc, Matija, Podbregar, Matej, Fabjan, Andrej, and Šoštarič, Maja

Abstract

Additional file 1 Table S1. Microembolic signals, average maximal velocity in arteria cerebri media during surgery and values of serum IL 6. Table S2. Multiple linear regression model, showing predictors for total intraoperative count of microemboli as a dependent value. Table S3. Multiple linear regression with natural logarithm of IL 66 h after surgery as a dependent variable. Table S4. Binominal logistic regression with postoperative occurrence of delirium as a dependent variable. Estimates represent the log odds of “Delirium = 1” vs. “Delirium = 0”. Table S5. Multiple linear regression with ICU stay (days) as a dependent variable. Table S6. Result of postoperative cognitive function testing (number of points) as a depended variable in multiple linear regression model.

Published
2021
Full Text
View/download PDF

40. High dexamethasone concentration prevents stimulatory effects of TNF-[alpha] and LPS on IL-6 secretion from the precursors of human muscle regeneration

Author

Prelovsek, Oja, Mars, Tomaz, Jevsek, Marko, Podbregar, Matej, and Grubic, Zoran

Subjects
Dexamethasone -- Research, Dexamethasone -- Physiological aspects, Corticosteroids -- Research, Muscle diseases -- Research, Muscle diseases -- Risk factors, Tumor necrosis factor -- Research, Biological sciences
Abstract

A frequent finding in patients surviving critical illness myopathy is chronic muscle dysfunction. Its pathogenesis is mostly unknown; one explanation could be that muscle regeneration, which normally follows myopathy, is insufficient in these patients because of a high glucocorticoid level in their blood. Glucocorticoids can prevent stimulatory effects of proinflammatory factors on the interleukin (IL)-6 secretion, diminishing in this way the autocrine and paracrine IL-6 actions known to stimulate proliferation at the earliest, myoblast stage of muscle formation. To test this hypothesis, we compared the effects of major proinflammatory agents [tumor necrosis factor (TNF)-[alpha] and endotoxin lipopolysaccharide (LPS)] on the IL-6 secretion from the muscle precursors and then studied the influence of dexamethasone (Dex) on these effects. Mononuclear myoblasts, which still proliferate, were compared with myotubes in which this capacity is already lost. For correct interpretation of results, cultures were examined for putative apoptosis and necrosis. We found that constitutive secretion of IL-6 did not differ significantly between myoblasts and myotubes; however, the TNF-[alpha]- and LPS-stimulated IL-6 release was more pronounced (P sepsis-induced myopathy; critical illness myopathy; myoblasts; myotubes; cytokines; glucocorticoids

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results