16 results on '"Pocobelli D."'
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2. Adherence issues related to sublingual immunotherapy as perceived by allergists
- Author
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Scurati, S., Frati, F., Passalacqua, G., Puccinelli, P., Hilaire, C., Incorvaia, C., D Avino, G., Comi, R., Lo Schiavo, M., Pezzuto, F., Montera, C., Pio, A., Teresa Ielpo, M., Cellini, F., Vicentini, L., Pecorari, R., Aresu, T., Capra, L., Benedictis, E., Bombi, C., Zauli, D., Vanzi, A., Alberto Paltrinieri, C., Bondioli, A., Paletta, I., Ventura, D., Mei, F., Paolini, F., Colangelo, C., Cavallucci, E., Cucinelli, F., Tinari, R., Ermini, G., Beltrami, V., Novembre, E., Begliomini, C., Marchese, E., Solito, E., Ammannati, V., Molino, G., Galli, E., Baldassini, M., Di Michele, L., Calvani, M., Gidaro, M., Venuti, A., Li Bianchi, E., Benassi, F., Pocobelli, D., Zangari, P., Rocco, M. 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- Subjects
medicine.medical_specialty ,Pathology ,genetic structures ,efficacy ,Alternative medicine ,Medicine (miscellaneous) ,Adherence, Cost, Efficacy, Side effects, Sublingual immunotherapy ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,sublingual immunotherapy ,ALLERGEN ,cost ,medicine ,Subcutaneous immunotherapy ,Sublingual immunotherapy ,adherence ,Clinical efficacy ,Intensive care medicine ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,sublingual immunoterapy ,Original Research ,Asthma ,AEROALLERGENS ,side effects ,business.industry ,Health Policy ,medicine.disease ,Slit ,eye diseases ,Clinical trial ,Patient Preference and Adherence ,immunotherapy ,sense organs ,Allergists ,ADHERENCE TO TREATMENT ,business ,Social Sciences (miscellaneous) - Abstract
Silvia Scurati1, Franco Frati1, Gianni Passalacqua2, Paola Puccinelli1, Cecile Hilaire1, Cristoforo Incorvaia3, Italian Study Group on SLIT Compliance 1Scientific and Medical Department, Stallergenes, Milan, Italy; 2Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyObjectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence.Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10.Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists.Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.Keywords: adherence, sublingual immunotherapy, efficacy, cost, side effects
- Published
- 2010
3. Delayed hypersensitivity to stepronin: a case report
- Author
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Romano, A., primary, Pietrantonio, F., additional, Di Fonso, M., additional, Pocobelli, D., additional, and Venuti, A., additional
- Published
- 1993
- Full Text
- View/download PDF
4. Repeated patch testing in delayed hypersensitivity to beta‐Iactam antibiotics
- Author
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Romano, A., primary, Fonso, M. Di, additional, Pietrantonio, F., additional, Pocobelli, D., additional, GIannarjini, L., additional, Bono, A. Del, additional, Fabrizi, G., additional, and Venuti, A., additional
- Published
- 1993
- Full Text
- View/download PDF
5. Anti-mitochondrial antibodies in pathologic myocardial hypertrophy. A comparison to athlete's hearth
- Author
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Autore, Camillo, Fiorito, Silvana, Fragola, P. V., Caselli, G., Pelliccia, A., Maccari, A. M., Picelli, A., Pocobelli, D., Cannata, D., and Sangiorgi, M.
- Published
- 1987
6. Studio immunogenetico in un gruppo di soggetti ipertesi
- Author
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Fiorito, Silvana, Autore, Camillo, Pocobelli, D., Purpura, M., Fragola, P. V., Picelli, A., and Cannata, D.
- Published
- 1986
7. Immunological aspects of different forms of cardiac hypertrophy
- Author
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Fiorito, Silvana, Pocobelli, D., Picelli, A. M., Maccari, A. M., Caselli, G., Pelliccia, A., Sommariva, L., Cannata, D., and Sangiorgi, M.
- Published
- 1987
8. Autoantibodies in myotonic dystrophy
- Author
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Fiorito, S., Pocobelli, D., Antonini, G., Picelli, A., Fragola, P. V., camillo autore, Magrini, L., and Cannata, D.
- Subjects
Adult ,Male ,Adolescent ,Humans ,Immunoglobulins ,Myotonic Dystrophy ,Female ,Complement System Proteins ,Middle Aged ,Autoantibodies - Abstract
We evaluated some immunological parameters in a group of 24 patients affected with myotonic dystrophy (MD). IgG, IgA, IgM immunoglobulin serum levels resulted decreased in most of the patients. Anti-smooth-muscle antibodies have been found in 10 out of 24 patients (45.5%). Moreover in some of them decreased C3 and C4 complement fraction serum levels have been found. Our data confirm the existence of some immunological abnormalities in a great number of subjects affected with the disease. Besides, these data evidence for most of the subjects the presence of autoantibodies non-organ-specific direct against myocellular antigens. These autoantibodies could be considered the expression of suffering of muscular fibres.
9. HLA-typing in hypertensive subjects
- Author
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Fiorito, S., camillo autore, Pocobelli, D., Fragola, P. V., Purpura, M., Picelli, A., and Paradiso, M.
10. Repeated patch testing in delayed hypersensitivity to beta-lactam antibiotics.
- Author
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Romano, A., di Fonso, M., Pietrantonio, F., Pocobelli, D., Giannarini, L., del Bono, A., Fabrizi, G., and Venuti, A.
- Subjects
DELAYED hypersensitivity ,BETA lactam antibiotics ,ALLERGIES ,CASE studies ,PENICILLIN ,ANTIBIOTICS - Abstract
The article focuses on repeated patch testing in delayed hypersensitivity to beta-lactam antibiotics. Findings are conflicting in evaluations of the stability of patch test positivity over time in patients with delayed hypersensitivity reactions to beta-lactam antibiotics. In cases of cutaneous eruptions linked to amino-penicillin's, it may be advisable, considering the side-chain specificity due to D( - )alfa position of the amino group, to limit patch testing to semi-synthetic penicillin reportedly used by the patient presented in the case.
- Published
- 1993
- Full Text
- View/download PDF
11. Nasal immunotherapy at constant dosage: a double-blind, placebo-controlled study in grass-allergic rhinoconjunctivitis.
- Author
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Pocobelli D, Del Bono A, Venuti L, Falagiani P, and Venuti A
- Subjects
- Adolescent, Adult, Allergens adverse effects, Allergens immunology, Conjunctivitis, Allergic immunology, Conjunctivitis, Allergic therapy, Double-Blind Method, Female, Humans, Male, Poaceae adverse effects, Poaceae immunology, Pollen adverse effects, Pollen immunology, Radioallergosorbent Test, Rhinitis, Allergic, Seasonal immunology, Rhinitis, Allergic, Seasonal therapy, Skin Tests, Treatment Outcome, Desensitization, Immunologic, Dose-Response Relationship, Immunologic
- Abstract
A preliminary open study showed that intranasal immunotherapy can be administered with a constant dosage scheduling, with good safety and efficacy. In the present study the efficacy of constant dosage intranasal immunotherapy has been evaluated on 43 grass-allergic rhinitis patients according to a double-blind placebo-controlled design. The product employed for the study had a formulation in powder, and was administrated by a nasal insufflator. Clinical efficacy was evaluated for each symptom, taking into consideration the severity of the symptom in relation to its frequency. Sneezing, rhinorrea, nasal blockage, eyes itching, and drug consumption were significantly improved in active-treated patients compared to placebo-treated. The safety of this treatment was good, the only adverse events observed being some local and mild symptoms. This immunotherapy was well-tolerated and easy to handle by the patients by self-administration.
- Published
- 2001
12. Two cases of toxic epidermal necrolysis caused by delayed hypersensitivity to beta-lactam antibiotics.
- Author
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Romano A, Di Fonso M, Pocobelli D, Giannarini L, Venuti A, and Garcovich A
- Subjects
- Adult, Female, Humans, beta-Lactams, Anti-Bacterial Agents adverse effects, Hypersensitivity, Delayed etiology, Stevens-Johnson Syndrome etiology
- Abstract
The authors describe two cases of toxic epidermal necrolysis (TEN) caused by delayed hypersensitivity to semisynthetic penicillins. The first patient developed erythema of the lower limbs following an i.m. injection of ampicillin, which progressed to TEN as therapy was continued. Fever and eosinophilic leukocytosis were also present. In the second case, TEN developed following oral amoxicillin therapy, and was preceded by a diffuse, maculopapular eruption. In both cases, symptoms resolved with the prompt administration of steroids. Both patients underwent allergological testing: prick test and, if results were negative, intradermal tests with penicilloyl-polylysine (PPL), minor determinant mixture (MDM), penicillin, amoxicillin and ampicillin. Patch testing with penicillin, ampicillin and amoxicillin was also performed. Both patients developed positive reactions to the intradermal tests after 6 h, and to patch tests after 48-72 h (for ampicillin, amoxicillin and penicillin in the first case, and for ampicillin and amoxicillin in the second). The lymphocyte transformation test (LTT), performed only in the first case, was positive for ampicillin. As these cases demonstrate, delayed hypersensitivity should be suspected in cases of drug-related TEN. Patch testing is a simple and useful allergological test for these types of cases.
- Published
- 1993
13. [Allergy to beta-lactam antibiotics in childhood. Diagnostic problems].
- Author
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Venuti A, Romano A, Pocobelli D, Rumi C, and Melaranci C
- Subjects
- Child, Child, Preschool, Drug Hypersensitivity etiology, Female, Humans, Infant, Male, beta-Lactams, Anti-Bacterial Agents adverse effects, Drug Hypersensitivity diagnosis
- Abstract
This study reports about 126 children with an age ranging from 12 months to 12 years having RA to beta-lactamase. More children with an age ranging from 7-12 years (59.5%), and more male (65.9%) than female subjects were studied. 76 patients (60.3%) showed a familial anamnesis of allergic diseases or similar diseases and a personal anamnesis of allergic diseases (45.2%). Among the RA responsible substances the more frequent were semisynthetic penicillin (44.6%) followed by cephalosporin and penicillin. Most clinical manifestations (87.3%) were cutaneous reactions and in smaller number of cases it was possible to observe gastroenteric or respiratory reactions. In 121 patients cutaneous tests were undertaken (Prick tests and intradermoreactions), patch tests, employing: PPL, MDM, Penicillin, Ampicillin, Cephaloridine. 5.8% of the studied subjects showed an allergy. Particularly 2.4% showed a "early" positivity. RAST was carried out in 92 patients and 3 of them showed a positive result (3.2%). This study stresses the opportunity to carry out allergologic tests within 6 months since the beginning of RA. In fact especially in children this test result can soon become negative. Furthermore the reduced percentage of positive allergologic tests can be due to the inclusion in other studies of patients with "coincidental reactions". A certain number of RA can be caused by additive to "per os" products. Finally it will be possible to use "tests dose" even in selectioned cases. These tests can frequently exclude the etiopathogenetic responsibility of beta-lactamic substances.
- Published
- 1992
14. Autoantibodies in myotonic dystrophy.
- Author
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Fiorito S, Pocobelli D, Antonini G, Picelli A, Fragola PV, Autore C, Magrini L, and Cannata D
- Subjects
- Adolescent, Adult, Complement System Proteins analysis, Female, Humans, Immunoglobulins analysis, Male, Middle Aged, Autoantibodies immunology, Myotonic Dystrophy immunology
- Abstract
We evaluated some immunological parameters in a group of 24 patients affected with myotonic dystrophy (MD). IgG, IgA, IgM immunoglobulin serum levels resulted decreased in most of the patients. Anti-smooth-muscle antibodies have been found in 10 out of 24 patients (45.5%). Moreover in some of them decreased C3 and C4 complement fraction serum levels have been found. Our data confirm the existence of some immunological abnormalities in a great number of subjects affected with the disease. Besides, these data evidence for most of the subjects the presence of autoantibodies non-organ-specific direct against myocellular antigens. These autoantibodies could be considered the expression of suffering of muscular fibres.
- Published
- 1989
15. [Platelet aggregation study with the impedance-measurement method in whole blood and in platelet-rich plasma. Results of a study on normal subjects].
- Author
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Galante A, Sommariva L, Pocobelli D, Iellamo F, Romitelli S, Ruscitti G, Lenci R, and Cannata D
- Subjects
- Adenosine Diphosphate, Adult, Collagen, Female, Humans, Male, Plethysmography, Impedance methods, Platelet Aggregation drug effects
- Published
- 1986
16. Antimitochondrial autoantibodies in myocardial hypertrophy: comparison between hypertrophic cardiomyopathy, hypertensive heart disease, and athlete's heart.
- Author
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Autore C, Fiorito S, Pelliccia A, Caselli G, Fragola PV, Picelli A, Maccari AM, Pocobelli D, Cannata D, and Sangiorgi M
- Subjects
- Adolescent, Adult, Aged, Antibodies, Antinuclear analysis, Cardiomegaly etiology, Cardiomegaly pathology, Cardiomyopathy, Hypertrophic pathology, Female, Humans, Hypertension complications, Immunoglobulins analysis, Male, Middle Aged, Muscle, Smooth immunology, Myocardium pathology, Parietal Cells, Gastric immunology, Sports, Autoantibodies analysis, Cardiomegaly immunology, Cardiomyopathy, Hypertrophic immunology, Mitochondria, Heart immunology
- Abstract
Antimitochondrial autoantibodies (AMA) were tested by indirect immunofluorescence in three groups of subjects with different types of myocardial hypertrophy: 35 patients affected with hypertrophic cardiomyopathy (HC), 20 patients with cardiac hypertrophy secondary to essential hypertension, and 35 active endurance athletes with exercise-induced left ventricular hypertrophy. Forty-two healthy subjects served as a control group. Left ventricular hypertrophy was considered a left ventricular mass (LVM) echocardiographically calculated (Devereux formula), exceeding 244 gm or a LVM index exceeding 122 gm/m2 (greater than 2 SD from a previously studied normal population). AMA were found in 15 of 35 (43%) patients with HC and in 6 of 20 (30%) patients with hypertensive heart disease (p less than 0.01); in contrast, AMA were not present in the sera of athletes or in the sera of controls. Although the significance of AMA in subjects with pathologic myocardial hypertrophy has not yet been established, their absence in the sera of athletes strengthens the opinion that cellular changes, as a compensatory response of the myocardium to a work overload, have a physiologic fashion in these cases. Moreover, identification of AMA in the sera of athletes with disproportionate severe left ventricular hypertrophy of uncertain origin may be helpful to ensure a single diagnosis.
- Published
- 1988
- Full Text
- View/download PDF
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