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6. THE EUROPEAN / INTERNATIONAL FIBROMUSCULAR DYSPLASIA REGISTRY: MAIN FINDINGS IN THE FIRST THOUSAND PATIENTS

Author

Pappaccogli, M., Di Monaco, S., Aparicio, L.S., Azizi, M., Bruno, R.M., de Leeuw, P.W., Delmotte, P., Gordin, D., Iwashima, Y., Januszewicz, A., Kroon, A.A., Lorthioir, A., Poch, E., Prejbisz, A., Seinturier, C., Toubiana, L., van der Niepen, P., Wang, J., Claude Wautrecht, J., Persu, A., and on behalf of the European/International Fibromuscular Dysplasia Initiative Investigators

Published
2019
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7. DISTINCTIVE FEATURES OF PATIENTS DIAGNOSED WITH FIBROMUSCULAR DYSPLASIA (FMD) AT AN OLDER AGE: A REPORT FROM THE EUROPEAN / INTERNATIONAL FMD REGISTRY

Author

Pappaccogli, M., Di Monaco, S., Amar, L., Aparicio, L.S., Azizi, M., Bruno, R.M., de Leeuw, P.W., Delmotte, P., Iwashima, Y., Januszewicz, A., Kroon, A.A., Poch, E., Prejbisz, A., Seinturier, C., Tikkanen, I., Toubiana, L., Van der Niepen, P., Scoppettuolo, P., Xu, J., Persu, A., and on behalf of the European/International Fibromuscular Dysplasia Initiative Investigators

Published
2019
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8. Patterns of care and survival for lung cancer: Results of the European population-based high-resolution study

Author

Sant, M, Daidone, C, Innos, K, Marcos-Gragera, R, Vanschoenbeek, K, Barranco, M, Poch, E, Lillini, R, Sant, Milena, Daidone, Caterina, Innos, Kaire, Marcos-Gragera, Rafael, Vanschoenbeek, Katrijn, Barranco, Miguel Rodriguez, Poch, Ester Oliva, Lillini, Roberto, Sant, M, Daidone, C, Innos, K, Marcos-Gragera, R, Vanschoenbeek, K, Barranco, M, Poch, E, Lillini, R, Sant, Milena, Daidone, Caterina, Innos, Kaire, Marcos-Gragera, Rafael, Vanschoenbeek, Katrijn, Barranco, Miguel Rodriguez, Poch, Ester Oliva, and Lillini, Roberto

Abstract

Objectives: To investigate differences in lung cancer (LC) management and survival using data from European population cancer registries. Methods: We analysed 4,602 lung cancer cases diagnosed in 2010-2013, followed-up to 2019 in five countries. Multivariable logistic regression was used to calculate the Odds Ratio (OR) of surgery for stages I-II LC or chemo- or radiotherapy for stages III-IV LC. Relative survival (RS) was estimated by the actuarial method; Relative Excess Risk of death (RER), with 95% CI, was calculated by generalized linear models. Results: Diagnostic work-up was extensive for 65.9% patients (range 57%, Estonia, Portugal - 85% (Belgium). Sixty-six percent of stages I-II patients underwent surgery; compared to non-operated, their adjusted OR decreased with age and was associated with main bronchus cancer (OR vs. lobes 0.25, CI, 0.08-0.82), stage II (OR vs. stage I: 0.42, CI, 0.29-0.60), comorbidity (OR vs. absent: 0.55, CI, 0.33-0.93), country (ORs: Estonia 1.82, CI, 1.28-2.60; Belgium 0.62, CI, 0.42-0.91; Portugal 0.69, CI, 0.52-0.93).Almost half of stages III-IV patients received chemo- or radiotherapy only; the adjusted OR vs. non receiving decreased with age and was associated with unspecified cancer topography or morphology. The adjusted five-year RER increased with age and stage and was lower for women (0.78, CI, 0.72-0.86), above the reference for main bronchus cancer (1.37, CI, 1.21-1.54) and unspecified morphology (1.17, CI, 1.05-1.30). Surgery carried the lowest mortality (RS 56.9; RER 0.13, CI, 0.11-0.15) with RER above the mean in Estonia (1.20, CI, 1.10-1.30), below it in Portugal (0.88, CI, 0.82-0.93) and Switzerland (0.91, CI, 0.84-0.99). Comorbidity (1.21, CI, 1.09-1.35) and not smoking (0.68, CI, 0.57-0.81) were associated with RER. Conclusions: The survival benefit of early diagnosis, allowing curative surgery, was evident at the population level. Screening for subjects at risk and adhesion to standard care should be incremented a

Published
2023

9. ENCEFALOPATÍA INDUCIDA POR CONTRASTE EN PACIENTES CON ENFERMEDAD RENAL CRÓNICA AVANZADA: AQUELLO QUE EL NEFRÓLOGO NECESITA SABER

Author

Escudero-Saiz, VJ, primary, ROMANI, NM, additional, Rodríguez, P, additional, Morantes, L, additional, Del Risco, J, additional, Casals, J, additional, Xipell, M, additional, Guillen, E, additional, Piñeiro, G J, additional, Blasco, M, additional, Rodas, L M, additional, Quintana, L F, additional, Poch, E, additional, Santana, D, additional, and Molina, A, additional

Published
2023
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10. Caracterización de la población con fracaso renal agudo durante la hospitalización por COVID-19 en España: tratamiento renal sustitutivo y mortalidad. Datos del Registro FRA-COVID SEN

Author

Salgueira, M, primary, Almenara, M, additional, Pizarraya, A Gutierrez, additional, Belmar, L, additional, Labrador, PJ, additional, Melero, R, additional, Serrano, M, additional, Portolés, JM, additional, Molina, A, additional, Poch, E, additional, Ramos, N, additional, Lloret, MJ, additional, Echarri, R, additional, Mancebo, R Díaz, additional, González- Lara, DM, additional, Sánchez, JE, additional, and Soler, MJ, additional

Published
2023
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12. Multimedia Elements in a Hybrid Multi-Agent System for the Analysis of Web Usability

Author

Mosqueira-Rey, E., del Río, B. Baldonedo, Alonso-Ríos, D., Rodríguez-Poch, E., Prado-Gesto, D., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Corchado, Emilio, editor, Graña Romay, Manuel, editor, and Manhaes Savio, Alexandre, editor

Published
2010
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17. The Density of Renal Lymphatics Correlates With Clinical Outcomes in IgA Nephropathy

Author

Rodas L, Barnadas E, Pereira A, Castrejon N, Saurina A, Calls J, Calzada Y, Alvaro Madrid Aris, Blasco M, Poch E, García-Herrera A, and Quintana LF

Subjects
IgAN, end-stage kidney disease, lymphatics, proteinuria
Abstract

INTRODUCTION: IgA nephropathy (IgAN) is the most common primary glomerulonephritis (GN) worldwide. The disease course fluctuates, and the most important challenge is the considerable variation in the time lag between diagnosis and the development of a hard clinical end point, such as end-stage kidney disease (ESKD). The reaction of renal tissue to damage resembles the common wound-healing response. One part of this repair in IgAN is the expansion of lymphatic vessels known as lymphangiogenesis. The aim of this work was to establish the prognostic value of the density of lymphatic vessels in the renal biopsy at the time of diagnosis, for predicting the risk of ESKD in a Spanish cohort of patients with IgAN. METHODS: We performed a retrospective multicenter study of 76 patients with IgAN. The end point of the study was progression to ESKD. The morphometric analysis of lymphatic vessels was performed on tissue sections stained with antipodoplanin antibody. RESULTS: Density of lymphatic vessels was significantly higher in patients with IgAN with mesangial hypercellularity >50%, segmental sclerosis, higher degrees of interstitial fibrosis, and tubular atrophy. Patients with more lymphatic vessels had significantly higher values of proteinuria and lower estimated glomerular filtration rate (eGFR). A density of lymphatic vessels =8 per mm(2) was associated with a significantly higher rate of progression to ESKD at 3 years from biopsy. After adjustment for the International IgAN prediction score, at the multivariate logistic regression, high density of lymphatic vessels (=8 per mm(2)) remained significantly associated with a higher rate of early progression to ESKD. CONCLUSION: This study contributes to the understanding of the natural history of the progression to ESKD in patients with IgAN revealing the density of lymphatics vessels may optimize the prognostic value of the International IgA predicting tool to calculate the risk of ESKD, favoring the evaluation of new targeted therapies.

Published
2022

19. Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry

Author

Pappaccogli, M, Prejbisz, A, Ciurică, S, Bruno, Rm, Aniszczuk-Hybiak, A, Bracalente, I, De Backer, T, Debiève, F, Delmotte, P, Di Monaco, S, Jarraya, F, Gordin, D, Kosiński, P, Kroon, Aa, Maas, Ahem, Marcon, D, Minuz, P, Montagud-Marrahi, E, Pasquet, A, Poch, E, Rabbia, F, Stergiou, Gs, Tikkanen, I, Toubiana, L, Vinck, W, Warchoł-Celińska, E, Van der Niepen, P, de Leeuw, P, Januszewicz, A, Persu, A, European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI) and the Working Group 'Hypertension and the Kidney' of the ESH: Alexandre Persu, Marco, Pappaccogli, Christophe, Beauloye, Patrick, Chenu, Jean-Philippe, Lengelé, Frank, Hammer, Pierre, Goffette, Parla, Astarci, André, Peeters, Robert, Verhelst, Miikka, Vikkula, Patricia Van der Niepen, Frank Van Tussenbroek, Tine De Backer, Sofie, Gevaert, Philippe, Delmotte, Wouter, Vinck, Daniel, T Gordin, Ilkka, Tikkanen, Maarit, Venermo, George, S Stergiou, Rosa Maria Bruno, Stefano, Taddei, Caterina, Romanini, Ilaria, Petrucci, Franco, Rabbia, Silvia Di Monaco, Pietro, Minuz, Mansueto, Giancarlo, DE MARCHI, Sergio, Denise, Marcon, Bram, Kroon, Peter de Leeuw, Andrzej, Januszewicz, Ewa, Warchol-Celinska, Aleksander, Prejbisz, Adam, Witkowski, Helena, Witowicz, Anna, Aniszczuk-Hybiak, Krzysztof, Pieluszczak, Magdalena, Januszewicz, Piotr, Dobrowolski, Esteban, Poch, Enrique, Montagud-Marrahi, Alicia, Molina, Elena, Guillen, Marta, Burrel, Hanen, Chaker, Faiçal, Jarraya, Anita, Mäkelä, Katarzyna, Józwik-Plebanek, Elżbieta, Florczak, Jacek, Kądziela, Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Interne Geneeskunde, MUMC+: MA Alg Interne Geneeskunde (9), and RS: Carim - V02 Hypertension and target organ damage

Subjects
Gestational hypertension, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], fibromuscular dysplasia, Comorbidity, Fibromuscular dysplasia, 030204 cardiovascular system & hematology, Aneurysm rupture, pregnancy-induced, Renal Artery, 0302 clinical medicine, Registries, CARDIOLOGY, OUTCOMES, 030219 obstetrics & reproductive medicine, Obstetrics, WOMEN, Middle Aged, EUROPEAN-SOCIETY, follow-up studies, 3. Good health, PREVALENCE, hypertension, pregnancy-induced, preeclampsia, pregnancy, Lower prevalence, cardiovascular system, Premature Birth, Female, Adult, medicine.medical_specialty, hypertension, Revascularization, DIAGNOSIS, CLASSIFICATION, Preeclampsia, Young Adult, 03 medical and health sciences, ANEURYSM, Internal Medicine, medicine, CORONARY-ARTERY DISSECTION, MANAGEMENT, Humans, In patient, cardiovascular diseases, Pregnancy, business.industry, medicine.disease, Pregnancy Complications, RISK-FACTORS, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], business
Abstract

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P P =0.003) but underwent more often renal revascularization (63% versus 40%, P

Published
2020

20. Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2

Author

Rao C, Suarez J, Martin R, Bauza C, Georgiadis A, Calvillo E, Hemphill J, Sung G, Oddo M, Taccone F, LeRoux P, Domeniconi G, Camputaro L, Villalobos M, Allasia M, Goldenberg F, Teran M, Rosciani F, Alvarez H, Costilla M, Videtta W, Perez D, Raffa P, Seppelt I, Rodgers H, Paxton J, Bhonagiri D, Aneman A, Jenkinson E, Bradford C, Finfer S, Yarad E, Bass F, Hammond N, O'Connor A, Bird S, Smith R, Barge D, Shilkin J, Woods W, Roberts B, O'Leary M, Vallance S, Helbok R, Beer R, Pfaulser B, Schiefecker A, Almemari A, Mukaddam S, Wittebole X, Berghe C, Dujardin M, Renard S, Hantson P, Biston P, Meyfroidt G, da Silva I, de Oliveira J, Neto A, Domingues J, Rodrigues P, Teitelbaum J, Chapman M, McCredie V, Marinoff N, Perez A, Kutsogiannis D, Bernard F, Kramer A, Moretti J, Aguilera S, Poch E, Romero C, Wong G, Song J, Xu G, Mejia-Mantilla J, Madrinan-Navia H, Martinez J, Ochoa M, Bautista D, Varga M, Gomez M, Ciro J, Gil B, Murillo R, Hernandez O, Ramirez-Arce J, Breitenfeld T, Gallardo A, Delgado H, Gonzalez J, Hache-Marliere M, Pinto D, Llano M, Salgado E, Jibaja M, Wright J, Harvey D, Verma V, Hopkins P, Chan A, Welbourne J, Dowling S, Katila A, Lasocki S, Wartenberg K, Hobohm C, Poli S, Schirotzek I, Bosel J, Schoenenberger S, Francken S, Shieber S, Kern A, Falla J, Herrera E, Gilvaz P, Goyal K, Sokhal N, Sohal J, Aggarwal D, Ray B, Pattnaik S, Garg S, Dixit S, Rawal R, Samavedam S, Madhusudan M, Paul G, Mishra S, Shushma P, Shukla U, Sinha V, Vanamoorthy P, Vadi S, Mokhtari M, Rasulo F, Pegoli M, Bilotta F, Nagayama M, Kobata H, Vosylius S, Abdullah J, Granillo J, Mijangos-Mendez J, Horn J, Muller M, Kuiper M, Abdo W, McArthur C, Newby L, Hashmi M, Shiraz S, Abrego G, Coronel E, Rivera O, Paucar J, Gomez O, Palo J, Lokin J, Misiewska-Kaczur A, Dias C, Amorim P, Andre S, Rodriguez-Vega G, Gritsan A, Titova Y, Al Jabbary A, Al Zahrani A, Pelunkova L, Zraiki H, Deeb A, Al Bshabshe A, Al-Jehani H, Al-Suwaidan F, Svigelj V, Ramos-Gomez L, Aguilar G, Badenes R, Pou J, Zavala E, Julian F, Barrachina L, Tegedor B, Tena S, Krauchi O, Tamayo G, Sanchez B, Gonzalezluengo R, Puvanendiran S, Merlani P, Laiwattana D, Promsin P, Nazliel B, Eriksson E, Chalela J, Miller D, Guisado R, Gordon E, Murthy H, Paulson A, Rajajee V, Sheehan K, Williamson C, Ball R, Allan P, Berkeley J, Muehlschlegel S, Carandang R, Hall W, Sarwal A, Damani R, Maldonado N, Tan B, Gupta P, Lazaridis C, Bershad E, Ansari S, Singares E, Manno E, Provencio J, Chaudhry B, McBride M, Dhar R, Roberts D, Allen M, Schumacher H, Habre W, Sheth K, Greer D, Kunze K, Varelas P, Tack L, Porter N, Junker C, Rodricks M, Tuppeny M, Basignani C, Napolitano S, Anderson G, Donaldson K, Davis R, Sternberg S, Giraldo E, Tran H, Coplin W, Badjatia N, Fathy A, Reshi R, Bonomo J, Seder D, Connolyy L, McCrum B, Carter T, Treggiari M, Dickinson M, Rison R, Mirski M, John S, Bleck T, Malek A, Trim T, Smith M, Athar M, Rincon F, Altaweel L, Vespa P, Emanuel B, Eskiogly E, McNett M, Sukumaran A, Shutter L, Milzman D, Glassner S, OPhelan K, Rosenthal E, Kottapally M, Smith W, Ko N, Josephson S, Kim A, Singhal N, Ahmad A, Meeker M, Hirsch K, Nair D, Chou S, Santos G, Clark S, Feske S, Henderson G, Sorond F, Vaitkevicius H, Chung D, Kim J, Amatangelo M, Kapinos G, Torbey M, Kahn D, Chang C, Koenig M, Gorman M, Langdon J, Dissin J, Cross L, Peled H, Claassen J, Ali A, Layon A, Miller A, Wilensky E, Kumar M, Levine J, Maldonado I, Schneck M, Lele A, Sarma A, Yazbeck M, Johnston G, Jarquin-Valdivia A, Johnson L, Kuisle L, Sajjad R, Glickman S, Garvin R, Parra A, DeFilippis M, Fletcher J, Freeman W, Rao V, Olmecah H, Dugan G, Medary I, Hoesch R, Brehaut S, Afshinnik A, Moreda M, Graffagnino C, Laskowitz D, Naidech A, Francis B, Berman M, Tesoro E, Medow J, Jordan D, Aiyagari V, Rosengart A, De Georgia M, Bowling S, Sharaby M, Nathan B, Landry R, Hebert C, Hubner K, Karanjia N, Hightower B, Cummings K, Kirkwood J, Frank J, Hassan A, Sanchez O, Cordina S, Mora J, Bui T, PRINCE Study Investigators, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de soins intensifs, and Meyfroidt, Geert

Subjects
medicine.medical_specialty, IMPACT, NEUROSCIENCES, Clinical Neurology, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], TRAUMATIC BRAIN-INJURY, UNITED-STATES, Outcomes, INTENSIVE-CARE, Critical Care and Intensive Care Medicine, Logistic regression, VALIDATION, 03 medical and health sciences, 0302 clinical medicine, Critical Care Medicine, General & Internal Medicine, Observational study, Intensive care, Severity of illness, Epidemiology, Neurocritical care, Medicine, Case report form, Science & Technology, business.industry, LENGTH-OF-STAY, Glasgow Coma Scale, Neurointensive care, 030208 emergency & critical care medicine, Critical care, Prospective, Emergency medicine, PATTERNS, Neurosciences & Neurology, Neurology (clinical), business, Life Sciences & Biomedicine, CRITICALLY-ILL PATIENTS, GLASGOW COMA SCALE, 030217 neurology & neurosurgery
Abstract

Contains fulltext : 218566pub.pdf (Publisher’s version ) (Closed access) Contains fulltext : 218566pos.pdf (Author’s version postprint ) (Open Access) BACKGROUND: Neurocritical care is devoted to the care of critically ill patients with acute neurological or neurosurgical emergencies. There is limited information regarding epidemiological data, disease characteristics, variability of clinical care, and in-hospital mortality of neurocritically ill patients worldwide. We addressed these issues in the Point PRevalence In Neurocritical CarE (PRINCE) study, a prospective, cross-sectional, observational study. METHODS: We recruited patients from various intensive care units (ICUs) admitted on a pre-specified date, and the investigators recorded specific clinical care activities they performed on the subjects during their first 7 days of admission or discharge (whichever came first) from their ICUs and at hospital discharge. In this manuscript, we analyzed the final data set of the study that included patient admission characteristics, disease type and severity, ICU resources, ICU and hospital length of stay, and in-hospital mortality. We present descriptive statistics to summarize data from the case report form. We tested differences between geographically grouped data using parametric and nonparametric testing as appropriate. We used a multivariable logistic regression model to evaluate factors associated with in-hospital mortality. RESULTS: We analyzed data from 1545 patients admitted to 147 participating sites from 31 countries of which most were from North America (69%, N = 1063). Globally, there was variability in patient characteristics, admission diagnosis, ICU treatment team and resource allocation, and in-hospital mortality. Seventy-three percent of the participating centers were academic, and the most common admitting diagnosis was subarachnoid hemorrhage (13%). The majority of patients were male (59%), a half of whom had at least two comorbidities, and median Glasgow Coma Scale (GCS) of 13. Factors associated with in-hospital mortality included age (OR 1.03; 95% CI, 1.02 to 1.04); lower GCS (OR 1.20; 95% CI, 1.14 to 1.16 for every point reduction in GCS); pupillary reactivity (OR 1.8; 95% CI, 1.09 to 3.23 for bilateral unreactive pupils); admission source (emergency room versus direct admission [OR 2.2; 95% CI, 1.3 to 3.75]; admission from a general ward versus direct admission [OR 5.85; 95% CI, 2.75 to 12.45; and admission from another ICU versus direct admission [OR 3.34; 95% CI, 1.27 to 8.8]); and the absence of a dedicated neurocritical care unit (NCCU) (OR 1.7; 95% CI, 1.04 to 2.47). CONCLUSION: PRINCE is the first study to evaluate care patterns of neurocritical patients worldwide. The data suggest that there is a wide variability in clinical care resources and patient characteristics. Neurological severity of illness and the absence of a dedicated NCCU are independent predictors of in-patient mortality.

Published
2019
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22. The European/international fibromuscular dysplasia registry and initiative (FEIRI) - Clinical phenotypes and their predictors based on a cohort of 1000 patients

Author

Pappaccogli, M, Di Monaco, S, Warchoł-Celińska, E, Lorthioir, A, Amar, L, Aparicio, Ls, Beauloye, C, Bruno, Rm, Chenu, P, de Leeuw, P, De Backer, T, Delmotte, P, Dika, Z, Gordin, D, Heuten, H, Iwashima, Y, Krzesinski, Jm, Kroon, Aa, Mazzolai, L, Poch, E, Sarafidis, P, Seinturier, C, Spiering, W, Toubiana, L, Van der Niepen, P, van Twist, D, Visonà, A, Wautrecht, Jc, Witowicz, H, Xu, J, Prejbisz, A, Januszewicz, A, Azizi, M, Persu, A, European/International FMD Registry and Initiative (FEIRI), and the Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) Collaborators: Lucas, S Aparicio, Alexandre, Persu, Marco, Pappaccogli, Christophe, Beauloye, Patrick, Chenu, Frank, Hammer, Pierre, Goffette, Parla, Astarci, André, Peeters, Robert, Verhelst, Miikka, Vikkula, Patricia Van der Niepen, Frank Van Tussenbroek, Tine De Backer, Sofie, Gevaert, Dimitri, Hemelsoet, Luc, Defreyne, Hilde, Heuten, Laetitia, Yperzeele, Thijs Van der Zijden, Jean-Philippe, Lengelé, Jean-Marie, Krzesinski, Muriel, Sprynger, Philippe, Delmotte, Peter, Verhamme, Thomas, Vanassche, Pasquale, Scoppettuolo, Jean-Claude, Wautrecht, Wouter, Vinck, Vassilev, Dobrin, Yaneva, Teodora, Jiguang, Wang, Jianzhong, Xu, Bojan, Jelaković, Zivka, Dika, Daniel, Gordin, Ilkka, Tikkanen, Maarit, Venermo, N Mäkelä, R, Pierre-François, Plouin, Xavier, Jeunemaitre, Laurent, Toubiana, Michel, Azizi, Laurence, Amar, Antoine, Chédid, Elie, Mousseaux, Aurélien, Lorthioir, Olivier, Ormezzano, Christopher, Seinturier, Frédéric, Thony, Felix, Mahfoud, Saarraaken, Kulenthiran, Pantelis, Sarafidis, Alexia, Piperidou, Michael, Doumas, George, S Stergiou, Demetrios, Vlahakos, Caitriona, Canning, Yehonatan, Sharabi, Alberto, Morganti, Rosa Maria Bruno, Stefano, Taddei, Caterina, Romanini, Ilaria, Petrucci, Franco, Rabbia, Silvia Di Monaco, Gian Paolo Rossi, Silvia, Lerco, Minuz, Pietro, Mansueto, Giancarlo, DE MARCHI, Sergio, Marcon, Denise, Patrizia, Salice, Adriana, Visonà, Paola, Bigolin, Viviana, Zingaretti, Rosario, Cianci, Marialuisa, Zedde, Maria Chiara Matteucci, Yoshio, Iwashima, Osami, Kawarada, Yoshito, Kadoya, Daan, J van Twist, Bram, Kroon, Peter de Leeuw, Wilko, Spiering, Bert-Jan van den Born, Aud, Høieggen, Martin Skage Sommer, Andrzej, Januszewicz, Ewa, Warchoł-Celińska, Aleksander, Prejbisz, Adam, Witkowski, Helena, Witowicz, Jacek, Kądziela, Aleksandra, Soplińska, Krzysztof, Pieluszczak, Katarzyna, Jóżwik-Plebanek, Magdalena, Januszewicz, Elżbieta, Florczak, Piotr, Dobrowolski, Eva, Szabóová, Marek, Hudák, Matej, Moščovič, Juan Diego Mediavilla, Fernando Jaen Aguila, Anna, Oliveras, Julian, Segura, Jose, C Prado, Nicolas Roberto Robles, Esteban, Poch, Enrique, Montagud-Marrahi, Alicia, Molina, Elena, Guillen, Marta, Burrel, Patricia Fernàndez De la Llama, Antonio, J Barros-Membrilla, Anders, Gottsäter, Gregor, Wuerzner, Lucia, Mazzolai, Giacomo, Buso, Faiçal, Jarraya, Hanen, Chaker, David, Adlam, Constantina, Chrysochou, Neeraj, Dhaun, Robert, W Hunter, Iain, Macintyre, David, Webb, Public and occupational health, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, APH - Personalized Medicine, APH - Global Health, ACS - Heart failure & arrhythmias, Interne Geneeskunde, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/DDUV/GEHU - Génétique, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de neurologie, and UCL - (SLuc) Service de chirurgie cardiovasculaire et thoracique

Subjects
Male, renovascular hypertension, Computed Tomography Angiography, Physiology, [SDV]Life Sciences [q-bio], Fibromuscular dysplasia, 030204 cardiovascular system & hematology, Magnetic resonance angiography, 0302 clinical medicine, Risk Factors, Prevalence, Registries, Renovascular hypertension, Stroke, Computed tomography angiography, medicine.diagnostic_test, fibromuscular dysplasia, dissection, aneurysm, stroke, Incidence, Dissection, Age Factors, Middle Aged, Prognosis, 3. Good health, Europe, Phenotype, Cohort, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, circulatory and respiratory physiology, Adult, medicine.medical_specialty, Asia, Tunisia, Aneurysm, Argentina, Risk Assessment, 03 medical and health sciences, Sex Factors, stomatognathic system, Predictive Value of Tests, Physiology (medical), Internal medicine, medicine, Humans, cardiovascular diseases, Aged, business.industry, medicine.disease, Aortic Dissection, Stenosis, Angiography, business, Magnetic Resonance Angiography, 030217 neurology & neurosurgery
Abstract

AIMS: Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections. METHODS AND RESULTS: All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on CTA, MRA and/or catheter-based angiography were eligible.Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46±16 years (12% ≥65yo), 86% were hypertensive, 72% had multifocal and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65yo had more often multifocal FMD, lower eGFR and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke and multivessel FMD. CONCLUSIONS: The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management and follow-up of FMD. TRANSLATIONAL PERSPECTIVE: Fibromuscular dysplasia (FMD) is nowadays considered as a systemic arterial disease, warranting brain-to-pelvis vascular imaging in all patients. However, most current evidence is derived from a limited number of expert centres. Furthermore, one size may not fit all. Based on analysis of the first thousand patients enrolled in the European/International FMD registry (46 centres; 22 countries) we characterized distinct patient profiles according to FMD subtype, age and gender and identified predictors of widespread disease, aneurysms and dissections, paving the way for individualized management and follow-up. Further studies will allow refining patient characterization according to ethnicity, genetic profile and imaging biomarkers.

Published
2021
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26. Complement as the enabler of carfilzomib-induced thrombotic microangiopathy

Author

Blasco, M, Martinez-Roca, A, Rodriguez-Lobato, LG, Garcia-Herrera, A, Rosinol, L, Castro, P, Fernandez, S, Quintana, LF, Cibeira, MT, Blade, J, de Larrea, CF, Tovar, N, Jimenez, R, Poch, E, Guillen, E, Campistol, JM, Carreras, E, Diaz-Ricart, M, and Palomo, M

Subjects
carfilzomib, C5b-9 deposits, drug-induced thrombotic microangiopathy, eculizumab, endothelial cells
Abstract

Carfilzomib has been associated with the development of thrombotic microangiopathy (TMA) in relapsed/refractory multiple myeloma patients, a severe disease with no currently available aetiological treatment. We evaluated the potential role of terminal complement pathway in four patients with carfilzomib-induced TMA. Membrane attack complex (C5b-9) deposition on endothelial cells in culture exposed to plasma from patients during the acute phase of the disease suggests complement overactivation as a mechanism of potential endothelial damage in three out of four patients. If confirmed in larger cohorts, C5b-9 evaluation will allow early identification of patients who could benefit from complement blockade and treatment monitoring.

Published
2021

27. Thrombotic microangiopathies assessment: mind the complement

Author

Blasco, M, Guillen, E, Quintana, LF, Garcia-Herrera, A, Pineiro, G, Poch, E, Carreras, E, Campistol, JM, Diaz-Ricart, M, and Palomo, M

Subjects
soluble C5b-9, C5b-9 deposits, thrombotic microangiopathies, membrane attack complex (C5b-9), complement system, endothelial cells (ECs)
Abstract

When faced with microangiopathic haemolytic anaemia, thrombocytopenia and organ dysfunction, clinicians should suspect thrombotic microangiopathy (TMA). The endothelial damage that leads to this histological lesion can be triggered by several conditions or diseases, hindering an early diagnosis and aetiological treatment. However, due to systemic involvement in TMA and its low incidence, an accurate early diagnosis is often troublesome. In the last few decades, major improvements have been made in the pathophysiological knowledge of TMAs such as thrombotic thrombocytopenic purpura [TTP, caused by ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin Type 1 motif, member 13) deficiency] and atypical haemolytic uraemic syndrome (aHUS, associated with dysregulation of the alternative complement pathway), together with enhancements in patient management due to new diagnostic tools and treatments. However, diagnosis of aHUS requires the exclusion of all the other entities that can cause TMA, delaying the introduction of terminal complement blockers, which have shown high efficacy in haemolysis control and especially in avoiding organ damage if used early. Importantly, there is increasing evidence that other forms of TMA could present overactivation of the complement system, worsening their clinical progression. This review addresses the diagnostic and therapeutic approach when there is clinical suspicion of TMA, emphasizing complement evaluation as a potential tool for the inclusive diagnosis of aHUS, as well as for the improvement of current knowledge of its pathophysiological involvement in other TMAs. The development of both new complement activation biomarkers and inhibitory treatments will probably improve the management of TMA patients in the near future, reducing response times and improving patient outcomes.

Published
2021

28. The European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)-clinical phenotypes and their predictors based on a cohort of 1000 patients

Author

Pappaccogli, M., Pappaccogli, M., Di Monaco, S., Warchol-Celinska, E., Lorthioir, A., Amar, L., Aparicio, L.S., Beauloye, C., Bruno, R.M., Chenu, P., de Leeuw, P., De Backer, T., Delmotte, P., Dika, Z., Gordin, D., Heuten, H., Iwashima, Y., Krzesinski, J.M., Kroon, A.A., Mazzolai, L., Poch, E., Sarafidis, P., Seinturier, C., Spiering, W., Toubiana, L., Van der Niepen, P., van Twist, D., Visona, A., Wautrecht, J.C., Witowicz, H., Xu, J.Z., Prejbisz, A., Januszewicz, A., Azizi, M., Persu, A., European/International FMD Registry and Initiative (FEIRI), Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH), Pappaccogli, M., Pappaccogli, M., Di Monaco, S., Warchol-Celinska, E., Lorthioir, A., Amar, L., Aparicio, L.S., Beauloye, C., Bruno, R.M., Chenu, P., de Leeuw, P., De Backer, T., Delmotte, P., Dika, Z., Gordin, D., Heuten, H., Iwashima, Y., Krzesinski, J.M., Kroon, A.A., Mazzolai, L., Poch, E., Sarafidis, P., Seinturier, C., Spiering, W., Toubiana, L., Van der Niepen, P., van Twist, D., Visona, A., Wautrecht, J.C., Witowicz, H., Xu, J.Z., Prejbisz, A., Januszewicz, A., Azizi, M., Persu, A., European/International FMD Registry and Initiative (FEIRI), and Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH)

Abstract

Aims Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections.Methods and results All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 +/- 16 years (12% >= 65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients >= 65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD.Conclusions The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD.

Published
2021

32. SARS-CoV-2–induced Acute Respiratory Distress Syndrome: Pulmonary Mechanics and Gas-Exchange Abnormalities

Author

Barbeta, Enric, primary, Motos, Ana, additional, Torres, Antoni, additional, Ceccato, Adrian, additional, Ferrer, Miquel, additional, Cilloniz, Catia, additional, Bueno, Leticia, additional, Badia, Joan Ramon, additional, Castro, Pedro, additional, Ferrando, Carlos, additional, Andrea, Rut, additional, Castellà, Manuel, additional, Fernández, Javier, additional, Soriano, Alex, additional, Mellado, Ricard, additional, López-Aladid, Rubén, additional, Yang, Hua, additional, Yang, Minlan, additional, Fernandez-Barat, Laia, additional, Catalina Palomeque, Andrea, additional, Vollmer, Ivan, additional, Nicolás, José María, additional, Almuedo, A., additional, Alonso, J. R., additional, Aziz, F., additional, Borrat, X., additional, Bragulat, E., additional, Carmona, I., additional, De Diego, O., additional, Farrero, M., additional, Fernández, S., additional, Forga, M., additional, Guasch, E., additional, Hernández-Tejero, M., additional, Jacas, A., additional, Leyes, P., additional, López, T., additional, Martínez, J. A., additional, Martínez-Palli, G., additional, Mercadal, J., additional, Muñoz, G., additional, Muñoz, J., additional, Navarro, R., additional, Ortiz, J., additional, Poch, E., additional, Pujol, M., additional, Quintana, E., additional, Reverter, E., additional, Rosselló, J., additional, Rovira, I., additional, Ruiz, P., additional, Sandoval, E., additional, Schneider, S., additional, Sibila, O., additional, Soy, D., additional, Suárez, M., additional, Téllez, A., additional, Toapanta, N. D., additional, and Urra, X., additional

Published
2020
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33. Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1

Author

Suarez, J. I., Martin, R. H., Bauza, C., Georgiadis, A., Venkatasubba Rao, C. P., Calvillo, E., Hemphill, J. C., Sung, G., Oddo, M., Taccone, Fabio Silvio, Leroux, P. D., Layon, A. J., Sarwal, A., Ali, A., Lele, A., Jarquin-Valdivia, A. A., Misiewska-Kaczur, A., Ahmad, A., Deeb, A. M., Jabbary, A. A., Fathy, A., Chan, A., Kern, CHRISTOPH ALEXANDER, Gritsan, A., Bshabshe, A. A., Malek, A., Schiefecker, A., Neto, A. R., ALHAJJ HASSAN, Ali, Zahrani, A. R. A., Sukumaran, A. V., Sarma, A. K., Aneman, A., Kramer, A., Naidech, A., Lacerda Gallardo, A. J., Miller, A., O'Connor, A., Kim, A., Afshinnik, A., Katila, A., Paulson, A., Parra, A., Rosengart, A., Almemari, A., Sanchez, B., Ray, B., Mccrum, B., Tegedor, B. V., Nathan, B., Tan, B., Emanuel, B., Pfaulser, B., Nazliel, B., Gil, B., Hightower, B., Francis, B., Roberts, B., Chaudhry, B., Romero, C., Graffagnino, C., VANDEN BERGHE, GREET CLARA, Hobohm, C., Dias, C., Bradford, C., Basignani, C., Chang, C., Junker, C., Lazaridis, C., Mcarthur, C., Williamson, C., Hebert, C., Ethan Kahn, D., Harvey, D., Laskowitz, D. T., Milzman, D., Chung, D., Greer, D., Seder, D., Miller, D. W., Barge, D., Roberts, D., Jordan, D., Bhonagiri, D., Nair, D., Aggarwal, D. G., Kutsogiannis, D. J., Laiwattana, D., Pinto, D. B., Bautista, D., Perez, D., Herrera, E. A., Singares, E. S., Manno, E., Wilensky, E. M., Giraldo, E. A., Jenkinson, E., Yarad, E., Zavala, E., Tesoro, E., Eskiogly, E., Bershad, E. M., Rosenthal, E., Coronel, E. B., Gordon, E., Salgado, E., Poch, E. J., Eriksson, E., Taccone, F. S., Al-Suwaidan, F., Sorond, F., Bilotta, F., Goldenberg, F. D., Rosciani, F., Bass, F., Bernard, F., Julian, F. B., Rasulo, F., Rincon, F., Santos, G., Anderson, G., Henderson, G., Meyfroidt, G., Wong, G. K. C., Aguilar, G., Rodriguez-Vega, G., Tamayo, G., Johnston, G., Kapinos, G., Abrego, G. C., Paul, G., Xu, G., Domeniconi, G., Dugan, G., Murthy, H. H. K., Peled, H., Zraiki, H., Alvarez, H., Rodgers, H., Vaitkevicius, H., Schumacher, H. C., Kobata, H., Al-Jehani, H., Lopez Delgado, H. J., Olmecah, H. M., Madrinan-Navia, H., Tran, H., Seppelt, I., Schirotzek, I., Medary, I. B., Maldonado, I. L., da Silva, I. R. F., Hemphill III, J. C., Javier Provencio, J., Mora, J. E., Abdullah, J. M., Langdon, J. R., Claassen, J., de Oliveira, J., Shilkin, J., Horn, J., Teitelbaum, J., Frank, J. I., Fletcher, J. J., Berkeley, J., Andersson, KIM JIMMY, Kirkwood, J., Welbourne, J., Song, J., Domingues, J. R. S., Paxton, J., Falla, J., Lokin, J., Dissin, J., Bonomo, J., Martinez, J. E., Mejia-Mantilla, J. H., Ramirez-Arce, J., Palo, J. E., Moretti, J. I., Gonzalez, J. R. Y., Levine, J. M., Medow, J., Pou, J. A. L., Ciro, J. D., Paucar, J. L. C., Wright, J. C., Bosel, J., Martinez, J., Mijangos-Mendez, J. C., Chalela, J., Granillo, J. F., Sohal, J., Hirsch, K. G., Donaldson, K., Cummings, K., Hubner, K. E., Wartenberg, K., Goyal, K., Sheth, K., Kunze, K., O'Phelan, K., Sheehan, K., Altaweel, L., Cross, L., Barrachina, L. G., Kuisle, L., Connolyy, L. S., Tack, L., Johnson, L., Shutter, L., Pelunkova, L., Ramos-Gomez, L. A., Camputaro, L. A., Kamran Athar, M., Madhusudan, M., Hashmi, M., Mokhtari, M., Jibaja, M., Muller, M. C. A., Costilla, M., Mirski, M., Ochoa, M. E., Pegoli, M., Dujardin, M. -F., Allasia, M., Teran, M. D., Gorman, Michael Murray, Chapman, M., Amatangelo, M., Nagayama, M., Dickinson, M., Koenig, M., Moreda, M., Berman, M., De Georgia, M., Kuiper, M., O'Leary, M., Rodricks, M., Schneck, M., Torbey, M., Defilippis, M., Meeker, M., Allen, David Michael, Llano, M., Villalobos, M., Treggiari, M., Tuppeny, M., Sharaby, M., Kottapally, M., Mcnett, M., Mcbride, M., Gomez, M., Varga, M., Kumar, M., Yazbeck, M. F., Smith, M., Stevenson Porter, N., Hammond, N., Karanjia, N., Sokhal, N., Singhal, N. S., Badjatia, N., Maldonado, N., Ko, N., Marinoff, N., Hernandez Aguilar, Orisel, Krauchi, O. R., Sanchez, O., Gomez, O., Rivera, O. S., Gilvaz, P. C., Raffa, P., Varelas, P., Promsin, P., Merlani, P., Shushma, P., Allan, P., Biston, P., Vespa, P., Amorim, P., de Azambuja Rodrigues, P. M., Hopkins, P., Hantson, P., Vanamoorthy, P., Gupta, P., Garvin, R., Badenes, R., Damani, R., Helbok, R., Dhar, R., Rawal, R., Carandang, R., Guisado, R., Luengo, R. -I. G., Sajjad, R., Davis, R., Rison, R. A., Hoesch, R., Murillo, R., Smith, R., Ball, R., Beer, R., Reshi, R. A., Landry, R., Puvanendiran, S., Ansari, S., Mukaddam, S., Garg, S., Mishra, S., Clark, S., Napolitano, Silvano, Pattnaik, S., Vosylius, S., John, S., Josephson, S. A., Glickman, S., Brehaut, S. S., Shiraz, S. A., Aguilera, S., Sternberg, S., Chou, S., Vallance, S., Lasocki, S., Schoenenberger, S., Bird, S., Finfer, S., Shieber, S., Vadi, S., Samavedam, S., Cordina, S., Feske, S., Glassner, S., Dixit, S., Dowling, S., Tena, S. A., Bowling, S., Francken, S., Muehlschlegel, S., Renard, S., Poli, S., Carter, T., Bleck, T. P., Trim, T., Breitenfeld, T., Van Bui, T., Shukla, U., Sinha, V., Rajajee, V., Aiyagari, V., Mccredie, V., Svigelj, V., Verma, V., Rao, V. A., David Freeman, W., Smith, W. S., Videtta, W., Habre, W., Hall, W., Coplin, W. M., Abdo, W. F., Wittebole, X., Titova, Y., PRINCE Study Investigators, Layon, A.J., Sarwal, A., Ali, A., Lele, A., Jarquin-Valdivia, A.A., Misiewska-Kaczur, A., Ahmad, A., Deeb, A.M., Jabbary, A.A., Fathy, A., Chan, A., Kern, A., Georgiadis, A., Gritsan, A., Bshabshe, A.A., Malek, A., Schiefecker, A., Neto, A.R., Hassan, A., Zahrani, ARA, Sukumaran, A.V., Sarma, A.K., Aneman, A., Kramer, A., Naidech, A., Lacerda Gallardo, A.J., Miller, A., O'Connor, A., Kim, A., Afshinnik, A., Katila, A., Paulson, A., Parra, A., Rosengart, A., Almemari, A., Sanchez, B., Ray, B., McCrum, B., Tegedor, B.V., Nathan, B., Tan, B., Emanuel, B., Pfaulser, B., Nazliel, B., Gil, B., Hightower, B., Francis, B., Roberts, B., Chaudhry, B., Romero, C., Graffagnino, C., Berghe, C., Hobohm, C., Dias, C., Bradford, C., Basignani, C., Chang, C., Venkatasubba Rao, C.P., Junker, C., Lazaridis, C., McArthur, C., Williamson, C., Hebert, C., Ethan Kahn, D., Harvey, D., Laskowitz, D.T., Milzman, D., Chung, D., Greer, D., Seder, D., Miller, D.W., Barge, D., Roberts, D., Jordan, D., Bhonagiri, D., Nair, D., Aggarwal, D.G., Kutsogiannis, D.J., Laiwattana, D., Pinto, D.B., Bautista, D., Perez, D., Herrera, E.A., Singares, E.S., Manno, E., Wilensky, E.M., Giraldo, E.A., Jenkinson, E., Yarad, E., Zavala, E., Tesoro, E., Eskiogly, E., Bershad, E.M., Rosenthal, E., Coronel, E.B., Gordon, E., Salgado, E., Poch, E.J., Calvillo, E., Eriksson, E., Taccone, F.S., Al-Suwaidan, F., Sorond, F., Bilotta, F., Goldenberg, F.D., Rosciani, F., Bass, F., Bernard, F., Julian, F.B., Rasulo, F., Rincon, F., Santos, G., Anderson, G., Henderson, G., Meyfroidt, G., Sung, G., Wong, GKC, Aguilar, G., Rodriguez-Vega, G., Tamayo, G., Johnston, G., Kapinos, G., Abrego, G.C., Paul, G., Xu, G., Domeniconi, G., Dugan, G., Murthy, HHK, Peled, H., Zraiki, H., Alvarez, H., Rodgers, H., Vaitkevicius, H., Schumacher, H.C., Kobata, H., Al-Jehani, H., Lopez Delgado, H.J., Olmecah, H.M., Madrinan-Navia, H., Tran, H., Seppelt, I., Schirotzek, I., Medary, I.B., Maldonado, I.L., da Silva, IRF, Hemphill Iii, J.C., Javier Provencio, J., Mora, J.E., Abdullah, J.M., Langdon, J.R., Claassen, J., de Oliveira, J., Shilkin, J., Horn, J., Teitelbaum, J., Frank, J.I., Fletcher, J.J., Berkeley, J., Kim, J., Kirkwood, J., Welbourne, J., Song, J., Domingues, JRS, Paxton, J., Falla, J., Lokin, J., Dissin, J., Bonomo, J., Martinez, J.E., Mejia-Mantilla, J.H., Ramirez-Arce, J., Palo, J.E., Moretti, J.I., Suarez, J.I., Gonzalez, JRY, Levine, J.M., Medow, J., Pou, JAL, Ciro, J.D., Paucar, JLC, Wright, J.C., Bosel, J., Martinez, J., Mijangos-Mendez, J.C., Chalela, J., Granillo, J.F., Sohal, J., Hirsch, K.G., Donaldson, K., Cummings, K., Hubner, K.E., Wartenberg, K., Goyal, K., Sheth, K., Kunze, K., O'Phelan, K., Sheehan, K., Altaweel, L., Cross, L., Barrachina, L.G., Kuisle, L., Connolyy, L.S., Tack, L., Johnson, L., Shutter, L., Pelunkova, L., Ramos-Gomez, L.A., Camputaro, L.A., Kamran Athar, M., Madhusudan, M., Hashmi, M., Mokhtari, M., Jibaja, M., Muller, MCA, Costilla, M., Mirski, M., Ochoa, M.E., Pegoli, M., Dujardin, M.F., Allasia, M., Teran, M.D., Gorman, M., Chapman, M., Amatangelo, M., Nagayama, M., Dickinson, M., Koenig, M., Moreda, M., Berman, M., De Georgia, M., Kuiper, M., O'Leary, M., Rodricks, M., Schneck, M., Torbey, M., DeFilippis, M., Meeker, M., Allen, M., Llano, M., Villalobos, M., Treggiari, M., Tuppeny, M., Sharaby, M., Kottapally, M., McNett, M., McBride, M., Gomez, M., Varga, M., Kumar, M., Yazbeck, M.F., Smith, M., Stevenson Porter, N., Hammond, N., Karanjia, N., Sokhal, N., Singhal, N.S., Badjatia, N., Maldonado, N., Ko, N., Marinoff, N., Hernandez, O., Krauchi, O.R., Sanchez, O., Gomez, O., Rivera, O.S., Gilvaz, P.C., Raffa, P., Varelas, P., Promsin, P., Merlani, P., Shushma, P., Allan, P., Biston, P., Vespa, P., Amorim, P., de Azambuja Rodrigues, P.M., Hopkins, P., Hantson, P., Vanamoorthy, P., Gupta, P., Garvin, R., Badenes, R., Damani, R., Helbok, R., Dhar, R., Rawal, R., Carandang, R., Guisado, R., Luengo, R.G., Sajjad, R., Davis, R., Rison, R.A., Hoesch, R., Murillo, R., Smith, R., Ball, R., Beer, R., Reshi, R.A., Landry, R., Puvanendiran, S., Ansari, S., Mukaddam, S., Garg, S., Mishra, S., Clark, S., Napolitano, S., Pattnaik, S., Vosylius, S., John, S., Josephson, S.A., Glickman, S., Brehaut, S.S., Shiraz, S.A., Aguilera, S., Sternberg, S., Chou, S., Vallance, S., Lasocki, S., Schoenenberger, S., Bird, S., Finfer, S., Shieber, S., Vadi, S., Samavedam, S., Cordina, S., Feske, S., Glassner, S., Dixit, S., Dowling, S., Tena, S.A., Bowling, S., Francken, S., Muehlschlegel, S., Renard, S., Poli, S., Carter, T., Bleck, T.P., Trim, T., Breitenfeld, T., Van Bui, T., Shukla, U., Sinha, V., Rajajee, V., Aiyagari, V., McCredie, V., Svigelj, V., Verma, V., Rao, V.A., David Freeman, W., Smith, W.S., Videtta, W., Habre, W., Hall, W., Coplin, W.M., Abdo, W.F., Wittebole, X., Titova, Y., Intensive Care Medicine, ANS - Neuroinfection & -inflammation, Other Research, ACS - Pulmonary hypertension & thrombosis, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs

Subjects
Internationality, Scope of practice, Latin Americans, medicine.medical_treatment, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Pharmacists, Critical Care and Intensive Care Medicine, law.invention, 0302 clinical medicine, Clinical Protocols, Central Nervous System Diseases, law, Observational study, Epidemiology, Neurocritical care, Case report form, Academic Medical Centers, Intensive care unit, Telemedicine, Europe, Intensive Care Units, Prospective, Transportation of Patients, Neurology, Practice Guidelines as Topic, Critical care, Outcomes, Original Work, Respiratory Therapy, medicine.medical_specialty, Asia, Tomography Scanners, X-Ray Computed, Critical Care, Health Personnel, Oceania, Respiratory therapist, Neurosurgery, Pharmacist, Personnel Management, Resource Allocation, Middle East, 03 medical and health sciences, Physicians, medicine, Humans, Fellowships and Scholarships, business.industry, Internship and Residency, Neurointensive care, 030208 emergency & critical care medicine, Latin America, Family medicine, North America, Neurology (clinical), business, Delivery of Health Care, 030217 neurology & neurosurgery
Abstract

Introduction Neurocritical care focuses on the care of critically ill patients with an acute neurologic disorder and has grown significantly in the past few years. However, there is a lack of data that describe the scope of practice of neurointensivists and epidemiological data on the types of patients and treatments used in neurocritical care units worldwide. To address these issues, we designed a multicenter, international, point-prevalence, cross-sectional, prospective, observational, non-interventional study in the setting of neurocritical care (PRINCE Study). Methods In this manuscript, we analyzed data from the initial phase of the study that included registration, hospital, and intensive care unit (ICU) organizations. We present here descriptive statistics to summarize data from the registration case report form. We performed the Kruskal–Wallis test followed by the Dunn procedure to test for differences in practices among world regions. Results We analyzed information submitted by 257 participating sites from 47 countries. The majority of those sites, 119 (46.3%), were in North America, 44 (17.2%) in Europe, 34 (13.3%) in Asia, 9 (3.5%) in the Middle East, 34 (13.3%) in Latin America, and 14 (5.5%) in Oceania. Most ICUs are from academic institutions (73.4%) located in large urban centers (44% > 1 million inhabitants). We found significant differences in hospital and ICU organization, resource allocation, and use of patient management protocols. The highest nursing/patient ratio was in Oceania (100% 1:1). Dedicated Advanced Practiced Providers are mostly present in North America (73.7%) and are uncommon in Oceania (7.7%) and the Middle East (0%). The presence of dedicated respiratory therapist is common in North America (85%), Middle East (85%), and Latin America (84%) but less common in Europe (26%) and Oceania (7.7%). The presence of dedicated pharmacist is highest in North America (89%) and Oceania (85%) and least common in Latin America (38%). The majority of respondents reported having a dedicated neuro-ICU (67% overall; highest in North America: 82%; and lowest in Oceania: 14%). Conclusion The PRINCE Study results suggest that there is significant variability in the delivery of neurocritical care. The study also shows it is feasible to undertake international collaborations to gather global data about the practice of neurocritical care. Electronic supplementary material The online version of this article (10.1007/s12028-019-00750-3) contains supplementary material, which is available to authorized users.

Published
2020

34. Pregnancy-related complications in patients with fibromuscular dysplasia: A report from the european/international fibromuscular dysplasia registry

Author

Pappaccogli, M. Prejbisz, A. Ciuricǎ, S. Bruno, R.M. Aniszczuk-Hybiak, A. Bracalente, I. De Backer, T. Debiève, F. Delmotte, P. Di Monaco, S. Jarraya, F. Gordin, D. Kosiński, P. Kroon, A.A. Maas, A.H.E.M. Marcon, D. Minuz, P. Montagud-Marrahi, E. Pasquet, A. Poch, E. Rabbia, F. Stergiou, G.S. Tikkanen, I. Toubiana, L. Vinck, W. Warchoł-Celińska, E. Van Der Niepen, P. De Leeuw, P. Januszewicz, A. Persu, A.

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P

Published
2020

35. DISTINCTIVE FEATURES OF PATIENTS DIAGNOSED WITH FIBROMUSCULAR DYSPLASIA (FMD) AT AN OLDER AGE: A REPORT FROM THE EUROPEAN/INTERNATIONAL FMD REGISTRY

Author

Pappaccogli, M., Di Monaco, S., Amar, L., Aparicio, L. S., Azizi, M., Bruno, R. M., De Leeuw, P. W., Delmotte, P., Iwashima, Y., Januszewicz, A., Kroon, A. A., Poch, E., Prejbisz, A., Seinturier, C., Tikkanen, I., Toubiana, L., Van Der Niepen, P., Scoppettuolo, P., Persu, Al., Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, and Nephrology

Published
2019
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36. THE EUROPEAN/INTERNATIONAL FIBROMUSCULAR DYSPLASIA REGISTRY: MAIN FINDINGS IN THE FIRST THOUSAND PATIENTS

Author

Pappaccogli, M., Di Monaco, S., Aparicio, L. S., Azizi, M., Bruno, R. M., De Leeuw, P. W., Delmotte, P., Gordin, D., Iwashima, Y., Januszewicz, A., Kroon, A. A., Lorthioir, A., Poch, E., Prejbisz, A., Seinturier, C., Toubiana, L., Van Der Niepen, P., Wang, J., Wautrecht, J. Claude, Persu, A., Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, and Faculty of Economic and Social Sciences and Solvay Business School

Published
2019

38. Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry

Author

Pappaccogli, M., Prejbisz, A., Ciurică, S., Bruno, R.M., Aniszczuk-Hybiak, A., Bracalente, I., Backer, T. De, Debiève, F., Delmotte, P., Monaco, S., Jarraya, F., Gordin, D., Kosiński, P., Kroon, A.A., Maas, A.H.E.M., Marcon, D., Minuz, P., Montagud-Marrahi, E., Pasquet, A., Poch, E., Rabbia, F., Stergiou, G.S., Tikkanen, I., Toubiana, L., Vinck, W., Warchoł-Celińska, E., Niepen, P. Van der, Leeuw, P. de, Januszewicz, A., Persu, A., Pappaccogli, M., Prejbisz, A., Ciurică, S., Bruno, R.M., Aniszczuk-Hybiak, A., Bracalente, I., Backer, T. De, Debiève, F., Delmotte, P., Monaco, S., Jarraya, F., Gordin, D., Kosiński, P., Kroon, A.A., Maas, A.H.E.M., Marcon, D., Minuz, P., Montagud-Marrahi, E., Pasquet, A., Poch, E., Rabbia, F., Stergiou, G.S., Tikkanen, I., Toubiana, L., Vinck, W., Warchoł-Celińska, E., Niepen, P. Van der, Leeuw, P. de, Januszewicz, A., and Persu, A.

Abstract

Contains fulltext : 225490.pdf (Publisher’s version ) (Closed access), Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P<0.001) and had a lower prevalence of cerebrovascular FMD (30% versus 52%; P=0.003) but underwent more often renal revascularization (63% versus 40%, P<0.001). In conclusion, the prevalence of pregnancy-related complications such as gestational hypertension and preterm birth was high in patients with FMD, probably related to the severity of renal FMD. However, the prevalence of preeclampsia and arterial complications was low/moderate. These findings emphasize the need to screen hypertensive women for FMD to ensure revascularization before pregnancy if indicated and appropriate follow-up during pregnancy, without discouraging patients with FMD from considering pregnancy.

Published
2020

43. Thermal fracturing on comets

Author

N. Attree, O. Groussin, L. Jorda, S. Rodionov, A.-T. Auger, N. Thomas, Y. Brouet, O. Poch, E. Kührt, M. Knapmeyer, F. Preusker, F. Scholten, J. Knollenberg, S. Hviid, P. Hartogh

Published
2018
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44. Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes mellitus and chronic kidney disease

Author

Yale, Jf, Bakris, G, Cariou, B, Nieto, J, David Neto, E, Yue, D, Wajs, E, Figueroa, K, Jiang, J, Law, G, Usiskin, K, Meininger, G, DIA3004 Study Group, Ansari, A, Arnouts, P, Assefi, A, Barreto, A, Barysheva, O, Bavanandam, S, Blaze, K, Bochenek, A, Bononi, P, Booth, W, Boyarkin, M, Burgess, L, Busch, K, Buse, J, Carranza, J, Cha, B, Chang, A, Clavel, S, Cockrell, Rc, Conway, J, Cook, W, Dande, A, De Los Rios MO, Deshmukh, V, Dobjanschi, C, Dotta, Francesco, Elliott, T, Ellis, G, Ferraro, R, Fishman, N, Fomin, V, Fraige Filho, F, Gagiu, R, Goh, Bl, Goldenberg, R, Gorriz, Jl, Gottschlich, G, Gouet, D, Grenfell, R, Griffin, C, Guarisco, M, Guerci, B, Henkel, E, Hramiak, I, Ison, R, Jadoul, M, Jang, H, Januszewicz, A, Kale, S, Karpova, I, Kaye, W, Kerstein, H, Kijanska, J, Kobalava, Z, Kong, N, Krasilnikova, E, Krebs, J, Kuczerowski, R, Kuzin, A, Kuzmenko, A, Laurens, W, Lim, Sk, Marasaev, V, Castelao, Am, Merker, L, Michlin, B, Morales, E, Motylev, I, Muse, D, Mutha, A, Neto, Ed, Nicholls, K, Niemetz, I, Iglesias, Jn, Ong, Lm, Onor, G, Packham, D, Petit, C, Piatti, M, Pirags, V, Poch, E, Ramirez, G, Riser, J, Roger, S, Ross, S, Rudolph, L, Sangumani, J, Schollum, J, Scott, R, Sebopa, B, Serafinceanu, C, Serusclat, P, Seufert, J, Siegmund, T, Silva, A, Skokowska, E, Smith, D, Sokolova, J, Solovyov, O, Steindorf, J, Stringam, S, Teterovska, D, Thivolet, C, Tytus, R, Vally, T, Van Vlem, B, Vercammen, C, Volkova, N, Warling, X, Winkler, L, Young, S, Zanella, Mt, and Zimmerer, M.

Subjects
Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Urinary system, Urology, Renal function, Blood Pressure, Thiophenes, Placebo, Drug Administration Schedule, Diabetic nephropathy, chemistry.chemical_compound, Endocrinology, Double-Blind Method, Glucosides, Sodium-Glucose Transporter 2, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Diabetic Nephropathies, Canagliflozin, Renal Insufficiency, Chronic, Sodium-Glucose Transporter 2 Inhibitors, Aged, Creatinine, business.industry, Body Weight, medicine.disease, Treatment Outcome, Blood pressure, Diabetes Mellitus, Type 2, chemistry, Disease Progression, Female, business, Glomerular Filtration Rate, Kidney disease, medicine.drug
Abstract

Aim This study evaluated the efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus (T2DM) and within a subset of Stage 3 chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] ≥30 and

Published
2014
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48. First Crio-extraction of Cherry Pit after Aspiration

Author

Gómez López A, Valipour A, Miguel Poch E, and García Luján R

Subjects
Bronchus, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Sedation, medicine.medical_treatment, Lumen (anatomy), Right lower lobe, Surgery, medicine.anatomical_structure, Bronchoscopy, medicine, Oral route, medicine.symptom, business, Foreign Bodies, Saline, Biomedical engineering
Abstract

Introduction: Vegetable foreign bodies (FB) are most commonly aspirated in children, these are very dangerous as most of them are hygroscopic, they swell up within a few days causing blockage of the lumen of the bronchus and retention of secretion distal to it. Method: We report on a 75 yr old patient who aspirated a cherry pit one month prior to clinical presentation. He originally presented with cough and a right lower lobe infiltrate on x-ray. The patient underwent therapeutic videobronchoscopy via the oral route, a cherry pit was detected at the distal end of the bronchus intermedius with signs of local inflammation. Result: We used saline rising and a flexible cryoprobe and it was activated for 15 s which resulted into a solid contact with the FB and immediate removal without complications. Conclusion: We have found that by using flexible cryoprobe through video bronchoscopy is possible remove a cherry pit under conscious sedation, which should be considered as a therapeutic option.

Published
2016
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50. Brain activity changes on healthy adults during variable-g maneuvers

Author

Processat Digital de Senyals en Entorns Aeroespacials i Biomèdics, Química Física i Inorgànica, Universitat Rovira i Virgili, Diana Dubert; X. Ruiz; Jna. Gavaldà; A. Perez_Poch; E. Domènech-Vadillo; V. Pascual, Processat Digital de Senyals en Entorns Aeroespacials i Biomèdics, Química Física i Inorgànica, Universitat Rovira i Virgili, and Diana Dubert; X. Ruiz; Jna. Gavaldà; A. Perez_Poch; E. Domènech-Vadillo; V. Pascual

Abstract

Filiació URV: SI COMPTE! Nota pel CRAI: el considerem article o pòster? Forma part de: Proceedings of the 18th World Congress of Psychophysiology (IOP2016) of the International Organization of Psychophysiology (IOP) Havana, Cuba August 31st to September 4th, 2016 A Scopus buscant-lo pel DOI no dóna resultats., In the last years increased attention directed towards the effect of the hyper/hypogravity on human body was reported, due to the great interest in raising the spatial mission. To understand the effect of short weightlessness periods on psychophysiological changes in human brain activity of normal healthy subjects, and how these changes may affect psychologically the person, present work reports the results obtained during a parabolic flight campaign effected using a small aerobatic plane. This aspect could help in the human survival within unsuitable environments. To perform the experiments, a small CAP10B single-engine aerobatic plane has been proposed and six healthy volunteers had accepted the challenge. The parabolic flight is characterized by gravity variations from 1g to approximately 3g, so called hypergravity phase, or reduced gravity down to 0.5g, so called hypogravity phase. During the flight the plain performed 12 parabolas in total, describing two types of experiments: within the first six parabolas the individuals had their eyes open and in the last six, the eyes closed. Electrocardigram, electroencephalogram, and oxygen content in the blood have been continuously recorded during the entire flight for all volunteers. In earlier work [Dubert et al. 2015] we discovered that changes of brain cortical activity involving the visual cortex and the limbic system are detected when the person sight is minimized. Concerning EEG data, the global intracortical

Published
2016

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