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4 results on '"Pöhner, Sarina"'

1. miR-16 and miR-103 impact 5-HT receptor signalling and correlate with symptom profile in irritable bowel syndrome

Author

Wohlfarth, Carolin, Schmitteckert, Stefanie, Härtle, Janina D., Houghton, Lesley A., Dweep, Harsh, Fortea, Marina, Assadi, Ghazaleh, Braun, Alexander, Mederer, Tanja, Pöhner, Sarina, Becker, Philip P., Fischer, Christine, Granzow, Martin, Mönnikes, Hubert, Mayer, Emeran A., Sayuk, Gregory, Boeckxstaens, Guy, Wouters, Mira M., Simrén, Magnus, Lindberg, Greger, Ohlsson, Bodil, Schmidt, Peter Thelin, Dlugosz, Aldona, Agreus, Lars, Andreasson, Anna, D'Amato, Mauro, Burwinkel, Barbara, Bermejo, Justo Lorenzo, Röth, Ralph, Lasitschka, Felix, Vicario Perez, Maria, Metzger, Marco, Santos, Javier, Rappold, Gudrun A., Martinez, Cristina, Niesler, Beate, and Universitat Autònoma de Barcelona

Published
2017

2. miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome

Author

Wohlfarth, Carolin, primary, Schmitteckert, Stefanie, additional, Härtle, Janina D., additional, Houghton, Lesley A., additional, Dweep, Harsh, additional, Fortea, Marina, additional, Assadi, Ghazaleh, additional, Braun, Alexander, additional, Mederer, Tanja, additional, Pöhner, Sarina, additional, Becker, Philip P., additional, Fischer, Christine, additional, Granzow, Martin, additional, Mönnikes, Hubert, additional, Mayer, Emeran A., additional, Sayuk, Gregory, additional, Boeckxstaens, Guy, additional, Wouters, Mira M., additional, Simrén, Magnus, additional, Lindberg, Greger, additional, Ohlsson, Bodil, additional, Schmidt, Peter Thelin, additional, Dlugosz, Aldona, additional, Agreus, Lars, additional, Andreasson, Anna, additional, D’Amato, Mauro, additional, Burwinkel, Barbara, additional, Bermejo, Justo Lorenzo, additional, Röth, Ralph, additional, Lasitschka, Felix, additional, Vicario, Maria, additional, Metzger, Marco, additional, Santos, Javier, additional, Rappold, Gudrun A., additional, Martinez, Cristina, additional, and Niesler, Beate, additional

Published
2017
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3. Su2083 Impaired miRNA Regulation as Molecular Cause of Altered 5-HT4 Receptor Signalling in Irritable Bowel Syndrome

Author

Wohlfarth, Carolin, primary, Härtle, Janina-Denise C., additional, Assadi, Ghazaleh, additional, Houghton, Lesley A., additional, Pöhner, Sarina, additional, Becker, Philip P., additional, Fischer, Christine, additional, Monnikes, Hubert, additional, Mayer, Emeran A., additional, Sayuk, Gregory S., additional, Boeckxstaens, Guy E., additional, Wouters, Mira M., additional, Simren, Magnus, additional, Lindberg, Greger, additional, Ohlsson, Bodil, additional, Schmidt, Peter T., additional, Dlugosz, Aldona, additional, Agreus, Lars, additional, Andreasson, Anna, additional, D'Amato, Mauro, additional, Burwinkel, Barbara, additional, Roeth, Ralph, additional, Lasitschka, Felix, additional, Rappold, Gudrun, additional, and Niesler, Beate, additional

Published
2014
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4. miR-16 and miR-103 impact 5-HT 4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.

Author

Wohlfarth C, Schmitteckert S, Härtle JD, Houghton LA, Dweep H, Fortea M, Assadi G, Braun A, Mederer T, Pöhner S, Becker PP, Fischer C, Granzow M, Mönnikes H, Mayer EA, Sayuk G, Boeckxstaens G, Wouters MM, Simrén M, Lindberg G, Ohlsson B, Schmidt PT, Dlugosz A, Agreus L, Andreasson A, D'Amato M, Burwinkel B, Bermejo JL, Röth R, Lasitschka F, Vicario M, Metzger M, Santos J, Rappold GA, Martinez C, and Niesler B

Subjects
Diarrhea, Down-Regulation, Gene Expression Regulation, Genetic Association Studies, Humans, Irritable Bowel Syndrome metabolism, Jejunum pathology, Mutation genetics, Phenotype, Polymorphism, Single Nucleotide, Protein Binding genetics, Quality of Life, Receptors, Serotonin, 5-HT4 metabolism, Signal Transduction, Work Performance, Irritable Bowel Syndrome genetics, Jejunum metabolism, MicroRNAs genetics, Receptors, Serotonin, 5-HT4 genetics
Abstract

Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT 4 receptors are promising candidates in IBS pathophysiology since they regulate gut motor function and stool consistency, and targeted 5-HT 4 R selective drug intervention has been proven beneficial in subgroups of patients. We identified a single nucleotide polymorphism (SNP) (rs201253747) c.*61 T > C within the 5-HT 4 receptor gene HTR4 to be predominantly present in diarrhoea-IBS patients (IBS-D). It affects a binding site for the miR-16 family and miR-103/miR-107 within the isoforms HTR4b/i and putatively impairs HTR4 expression. Subsequent miRNA-profiling revealed downregulation of miR-16 and miR-103 in the jejunum of IBS-D patients correlating with symptoms. In vitro assays confirmed expression regulation via three 3'UTR binding sites. The novel isoform HTR4b_2 lacking two of the three miRNA binding sites escapes miR-16/103/107 regulation in SNP carriers. We provide the first evidence that HTR4 expression is fine-tuned by miRNAs, and that this regulation is impaired either by the SNP c.*61 T > C or by diminished levels of miR-16 and miR-103 suggesting that HTR4 might be involved in the development of IBS-D.

Published
2017
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