1. Diagnostic value of miR-34a in Mycoplasma pneumoniae pneumonia in children and its correlation with rehabilitation effect.
- Author
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Li M, Lu L, and Xu H
- Subjects
- Humans, Male, Female, Child, Child, Preschool, Biomarkers blood, Mycoplasma pneumoniae genetics, Pneumonia, Mycoplasma diagnosis, Pneumonia, Mycoplasma blood, MicroRNAs blood
- Abstract
Background: Mycoplasma pneumoniae pneumonia (MPP) is responsible for 20 to 40% of all cases of pneumonia acquired by children and shows an increasing incidence year by year. The aim of this study was to investigate the expression of miR-34a in children with MPP and its diagnostic value, and further explore the relationship between miR-34a and the rehabilitation effect of children with MPP., Methods: The expression level of miR-34a was detected by RT-qPCR, and the clinical value of miR-34a was analyzed by ROC analysis. In addition, the levels of IL-6, IL-18 and TNF-α in serum of children with MPP were detected by ELISA kit, and the correlation with miR-34a was analyzed., Results: Elevated levels of miR-34a were observed in the serum of children with MPP, and significantly higher expression levels were observed in children with severe symptoms and poor rehabilitation. The study suggested that miR-34a has potential as a diagnostic marker for MPP in children, helping to distinguish between mild and severe cases and predicting rehabilitation from MPP in children. In addition, miR-34a expression was positively correlated with IL-6, IL-8, and TNF-α levels., Conclusions: miR-34a is closely related to MPP in children and miR-34a may be used as a clinical biomarker for MPP in children., (© 2024. The Author(s).)
- Published
- 2024
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