Search

Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 mug/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.

Ovariectomy in rats induces the activation of lipid peroxidation processes, reduces total lipid content, and decreases the accumulation of lysophospholipids in erythrocyte membranes. The administration of Maackia amurensis extract (200 mg/kg, p.o., during 14 days) reduces the level of lipid peroxidation, prevents a decrease in the total lipid content, normalizes the proportion of lipids and proteins, and eliminates the accumulation of lysophospholipids in erythrocyte membranes in ovariectomized rats.

Ovariectomy reduces blood levels of sex hormones and considerably increases blood viscosity due to an increase in hematocrit and plasma fibrinogen content, disorders in viscoelastic characteristics of erythrocytes, and increase of their aggregation activity. Changes in the macrorheology are mainly responsible for the development of the hyperviscosity syndrome.