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30 results on '"Ploner, Meinhard"'

12. Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods.

Author

Jaki, Thomas, Wolfsegger, Martin J., Ploner, Meinhard, Jaki, Thomas, Wolfsegger, Martin J., and Ploner, Meinhard

Abstract

Pharmacokinetic studies are commonly performed using the two-stage approach. The first stage involves estimation of pharmacokinetic parameters like the area under the concentration versus time curve (AUC) for each analysis subject separately and the second stage uses the individual parameter estimates for statistical inference. This two-stage approach is not applicable in sparse sampling situations where only one sample is available per analysis subject like in non-clinical in-vivo studies. In a serial sampling design only one sample is taken from each analysis subject. A simulation study was carried out to assess coverage, power and type I error of seven methods to construct two-sided 90% confidence intervals for ratios of two AUC's assessed in a serial sampling design, which can be used to assess bioequivalence in this parameter.

Published
2009

20. TP53 Genotype but Not p53 Immunohistochemical Result Predicts Response to Preoperative Short-Term Radiotherapy in Rectal Cancer

Author

Kandioler, Daniela, primary, Zwrtek, Ronald, additional, Ludwig, Carmen, additional, Janschek, Elisabeth, additional, Ploner, Meinhard, additional, Hofbauer, Friedrich, additional, Kührer, Irene, additional, Kappel, Sonja, additional, Wrba, Friedrich, additional, Horvath, Manfred, additional, Karner, Josef, additional, Renner, Karl, additional, Bergmann, Michael, additional, Karner-Hanusch, Judith, additional, Pötter, Richard, additional, Jakesz, Raimund, additional, Teleky, Bela, additional, and Herbst, Friedrich, additional

Published
2002
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29. Vascular morphometric changes after radioactive stent implantation: a dose-response analysis.

Author

Wexberg, Paul, Kirisits, Christian, Gyöngyösi, Mariann, Gottsauner-Wolf, Michael, Ploner, Meinhard, Pokrajac, Boris, Pötter, Richard, and Glogar, Dietmar

Abstract

Objectives: The goal of this study was to evaluate the dose-dependency of morphometric changes in the coronary arterial wall after radioactive stenting.Background: Radioactive stents have been found to reduce intrastent intimal hyperplasia (IIH) but lead to a characteristic type of restenosis occurring predominantly at the stent edges.Methods: Fifteen patients underwent intravascular ultrasound (IVUS) examination after implantation of a P-32 radioactive stent and at the six-month follow-up. The post-stent IVUS measurements on seven predefined locations of each lesion were subjected to a computer algorithm for the development of dose-volume histograms (DVH). Thus, we derived the radiation doses delivered to at least 10% and 90% of the adventitia (DV10, DV90). The IIH and vascular remodeling at follow-up were correlated with the doses in each segment.Results: The IIH was most pronounced at the stent edges and lowest in the stent-body, whereas we detected a significant expansive remodeling within the stent body. The delivered doses correlated with a decreased IIH (r = 0.52, p < 0.001 for DV10 and r = 0.62, p < 0.001 for DV90) and with expansive remodeling (r = 0.48, p = 0.009 for DV10 and r = 0.50, p = 0.006 for DV90). A DV10 >90 Gy or a DV90 >15 Gy reduced IIH and induced expansive remodeling. Plaque growth was not reduced by radioactive stents.Conclusions: The DVH analysis reveals a dose-dependent increase of external elastic lamina area behind radioactive stents, whereas plaque growth is not reduced but inverted into an outward direction from the stent. A DV10 >90 Gy or a DV90 >15 Gy results in a beneficial long-term outcome after radioactive stenting. [ABSTRACT FROM AUTHOR]

Published
2002
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30. Confidence intervals for ratios of AUCs in the case of serial sampling: a comparison of seven methods.

Author

Jaki T, Wolfsegger MJ, and Ploner M

Subjects
Humans, Pharmacokinetics, Research Design, Sample Size, Therapeutic Equivalency, Area Under Curve, Confidence Intervals, Data Interpretation, Statistical
Abstract

Pharmacokinetic studies are commonly performed using the two-stage approach. The first stage involves estimation of pharmacokinetic parameters such as the area under the concentration versus time curve (AUC) for each analysis subject separately, and the second stage uses the individual parameter estimates for statistical inference. This two-stage approach is not applicable in sparse sampling situations where only one sample is available per analysis subject similar to that in non-clinical in vivo studies. In a serial sampling design, only one sample is taken from each analysis subject. A simulation study was carried out to assess coverage, power and type I error of seven methods to construct two-sided 90% confidence intervals for ratios of two AUCs assessed in a serial sampling design, which can be used to assess bioequivalence in this parameter.

Published
2009
Full Text
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