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2. Evaluatie en actualisatie ontheffing natuurlijke vijanden

Author

Bastiaanssen, V., Saes, L., Karsten, E., Cloosterman, E., Ploeg, M., Bastiaanssen, V., Saes, L., Karsten, E., Cloosterman, E., and Ploeg, M.

Abstract

Voor alle overige natuurlijke vijanden die niet onder op de vrijstellingslijsten staan, moet een ontheffing aangevraagd worden. Dit is een uitzondering op een wettelijk verbod in een enkel geval, in deze context een uitzondering voor een producent van natuurlijke vijanden voor een periode van vijf jaar. Deze ontheffing kan aangevraagd worden via RVO, door middel van een elektronische aanvraag. Deze evaluatie betreft deze ontheffing. In de context van het uitvoeringsprogramma Toekomstvisie gewasbescherming 2030 is vanuit verschillende betrokkenen is de vraag gesteld of het mogelijk is om de systematiek van het aanvragen van ontheffingen voor natuurlijke vijanden aan te passen. Deze evaluatie moet inzicht geven in hoe partijen de huidige systematiek ervaren en hoe doelmatig de systematiek is (terugblik). Daarnaast geven we aanbevelingen voor de mogelijkheden om de systematiek aan te passen.

Published
2023

3. Gamma delta T cells are effectors of immunotherapy in cancers with HLA class I defects

Author

Vries, N.L. de, Haar, J. van de, Veninga, V., Chalabi, M., Ijsselsteijn, M.E., Ploeg, M. van der, Bulk, J. van den, Ruano, D., Berg, J.G. van den, Haanen, J.B., Zeverijn, L.J., Geurts, B.S., Wit, G.F. de, Battaglia, T.W., Gelderblom, H., Verheul, H.M.W., Schumacher, T.N., Wessels, L.F.A., Koning, F., Miranda, N.F.C.C. de, and Voest, E.E.

Abstract

DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to explain their exceptional responsiveness to immune checkpoint blockade (ICB)(1,2). Here, in contrast to other cancer types(3-5), we observed that 20 out of 21 (95%) MMR-d cancers with genomic inactivation of beta 2-microglobulin (encoded by B2M) retained responsiveness to ICB, suggesting the involvement of immune effector cells other than CD8(+) T cells in this context. We next identified a strong association between B2M inactivation and increased infiltration by gamma delta T cells in MMR-d cancers. These gamma delta T cells mainly comprised the V delta 1 and V delta 3 subsets, and expressed high levels of PD-1, other activation markers, including cytotoxic molecules, and a broad repertoire of killer-cell immunoglobulin-like receptors. In vitro, PD-1(+) gamma delta T cells that were isolated from MMR-d colon cancers exhibited enhanced reactivity to human leukocyte antigen (HLA)-class-I-negative MMR-d colon cancer cell lines and B2M-knockout patient-derived tumour organoids compared with antigen-presentation-proficient cells. By comparing paired tumour samples from patients with MMR-d colon cancer that were obtained before and after dual PD-1 and CTLA-4 blockade, we found that immune checkpoint blockade substantially increased the frequency of gamma delta T cells in B2M-deficient cancers. Taken together, these data indicate that gamma delta T cells contribute to the response to immune checkpoint blockade in patients with HLA-class-I-negative MMR-d colon cancers, and underline the potential of gamma delta T cells in cancer immunotherapy.

Published
2023

6. 733MO γδT cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

Author

Van De Haar, J., primary, de Vries, N.L., additional, Veninga, V., additional, Chalabi, M., additional, Ijsselsteijn, M., additional, van der Ploeg, M., additional, van den Bulk, J., additional, Ruano, D., additional, Haanen, J.B.A.G., additional, Schumacher, T.N., additional, Wessels, L.F.A., additional, Koning, F., additional, de Miranda, N.F.C.C., additional, and Voest, E.E., additional

Published
2022
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9. Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis

Author

Liang, C, Zhang, S, Robinson, D, Vander Ploeg, M, Wilson, R, Nah, J, Taylor, D, Beh, S, Lim, R, Sun, L, Muoio, DM, Stroud, DA, Ho, L, Liang, C, Zhang, S, Robinson, D, Vander Ploeg, M, Wilson, R, Nah, J, Taylor, D, Beh, S, Lim, R, Sun, L, Muoio, DM, Stroud, DA, and Ho, L

Abstract

Electron transport chain (ETC) biogenesis is tightly coupled to energy levels and availability of ETC subunits. Complex III (CIII), controlling ubiquinol:ubiquinone ratio in ETC, is an attractive node for modulating ETC levels during metabolic stress. Here, we report the discovery of mammalian Co-ordinator of mitochondrial CYTB (COM) complexes that regulate the stepwise CIII biogenesis in response to nutrient and nuclear-encoded ETC subunit availability. The COMA complex, consisting of UQCC1/2 and membrane anchor C16ORF91, facilitates translation of CIII enzymatic core subunit CYTB. Subsequently, microproteins SMIM4 and BRAWNIN together with COMA subunits form the COMB complex to stabilize nascent CYTB. Finally, UQCC3-containing COMC facilitates CYTB hemylation and association with downstream CIII subunits. Furthermore, when nuclear CIII subunits are limiting, COMB is required to chaperone nascent CYTB to prevent OXPHOS collapse. Our studies highlight CYTB synthesis as a key regulatory node of ETC biogenesis and uncover the roles of microproteins in maintaining mitochondrial homeostasis.

Published
2022

10. Grondwatertemperatuur op drift: een kans om hydrogeologische systemen door te lichten

Author

Bense, V., Kruijssen, T., Ploeg, M. van der, Bense, V., Kruijssen, T., and Ploeg, M. van der

Abstract

Grondwatertemperatuur-diepteprofielen worden al lange tijd gebruikt om de verticale component van grondwaterstroming te berekenen. Hierbij wordt aangenomen dat het temperatuurprofiel stabiel is in de tijd. Grondwatertemperaturen in de Nederlandse ondergrond zijn echter al waarschijnlijk sinds eind jaren 60 aan het toenemen als gevolg van een atmosferische opwarming en verstedelijking. Dit blijkt uit een analyse van temperatuur-dieptemetingen in peilbuizen uit de jaren 70 en 80 van de vorige eeuw, vergeleken met recente data verkregen op dezelfde locaties. Als gevolg van de huidige opwarming van het grondwater zijn klassieke methodes om met grondwatertemperatuurmetingen grondwaterstroming in kaart te brengen steeds minder goed toepasbaar. In dit artikel laten we zien hoe met behulp van een nieuwe methode de temperatuur-diepte profielen toch gebruikt kunnen worden voor het correct inschatten van verticale grondwaterstroming. Daartoe analyseren we de variatie in diepte tot waar het signaal van opwarming aan het oppervlak te zien is in temperatuur-dieptedata verzameld in en rondom het Renkums Beekdal. De berekende verticale grondwaterstroming is in combinatie met stijghoogtemetingen gebruikt om de verticale hydraulische doorlatendheid van de Waalre aquitard te berekenen. Deze blijkt goed overeen te komen met waardes in REGIS. We concluderen daarom dat met onze methode temperatuur-diepteprofielen die verstoord zijn door opwarming kwantitatief geïnterpreteerd kunnen worden om verticale grondwaterstroomsnelheden te bepalen.

Published
2022

14. A Field Guide for Monitoring Riverine Macroplastic Entrapment in Water Hyacinths

Author

Schreyers, L., Emmerik, T., Nguyen, T.L., Phung, N-A., Kieu-Le, T-C., Castrop, E., Kosten, S., Berg, S.J.P., Ploeg, M van der, Schreyers, L., Emmerik, T., Nguyen, T.L., Phung, N-A., Kieu-Le, T-C., Castrop, E., Kosten, S., Berg, S.J.P., and Ploeg, M van der

Abstract

Contains fulltext : 236348.pdf (Publisher’s version ) (Open Access)

Published
2021

18. We’ve got a Problem: New Perspectives on the Problemistic Search Paradox

Author

Ploeg, M., Vermeulen, P.A.M., Knoben, J., and Radboud University Nijmegen

Subjects
Institute for Management Research
Abstract

Contains fulltext : 214172.pdf (Publisher’s version ) (Open Access) Radboud University, 21 september 2020 Promotores : Vermeulen, P.A.M., Knoben, J.

Published
2020

21. The handbook for standardized field and laboratory measurements in terrestrial climate change experiments and observational studies (ClimEx)

Author

Halbritter, A.H., De, Boeck, H.J., Eycott, A.E., Reinsch, S., Robinson, D.A., Vicca, S., Berauer, B., Christiansen, C.T., Estiarte, M., Grünzweig, J.M., Gya, R., Hansen, K., Jentsch, A., Lee, H., Linder, S., Marshall, J., Peñuelas, J., Kappel, Schmidt, I., Stuart-Haëntjens, E., Wilfahrt, P., Vandvik, V., Abrantes, N., Almagro, M., Althuizen, I.H.J., Barrio, I.C., Te, Beest, M., Beier, C., Beil, I., Carter, Berry, Z., Birkemoe, T., Bjerke, J.W., Blonder, B., Blume-Werry, G., Bohrer, G., Campos, I., Cernusak, L.A., Chojnicki, B.H., Cosby, B.J., Dickman, L.T., Djukic, I., Filella, I., Fuchslueger, L., Gargallo-Garriga, A., Gillespie, M.A.K., Goldsmith, G.R., Gough, C., Halliday, F.W., Hegland, S.J., Hoch, G., Holub, P., Jaroszynska, F., Johnson, D.M., Jones, S.B., Kardol, P., Keizer, J.J., Klem, K., Konestabo, H.S., Kreyling, J., Kröel-Dulay, G., Landhäusser, S.M., Larsen, K.S., Leblans, N., Lebron, I., Lehmann, M.M., Lembrechts, J.J., Lenz, A., Linstädter, A., Llusià, J., Macias-Fauria, M., Malyshev, A.V., Mänd, P., Marshall, M., Matheny, A.M., McDowell, N., Meier, I.C., Meinzer, F.C., Michaletz, S.T., Miller, M.L., Muffler, L., Oravec, M., Ostonen, I., Porcar Castell, Albert, Preece, C., Prentice, I.C., Radujkovic, D., Ravolainen, V., Ribbons, R., Ruppert, J.C., Sack, L., Sardans, J., Schindlbacher, A., Scoffoni, C., Sigurdsson, B.D., Smart, S., Smith, S.W., Soper, F., Speed, J.D.M., Sverdrup-Thygeson, A., Sydenham, M.A.K., Taghizadeh-Toosi, A., Telford, R.J., Tielbörger, K., Töpper, J.P., Urban, O., Van der, Ploeg, M., Van Langenhove, L., Vecerová, K., Ven, A., Verbruggen, E., Vik, U., Weigel, R., Wohlgemuth, T., Wood, L.K., Zinnert, J., Zurba, K., the, ClimMani, Working, Group, Halbritter, A.H., De, Boeck, H.J., Eycott, A.E., Reinsch, S., Robinson, D.A., Vicca, S., Berauer, B., Christiansen, C.T., Estiarte, M., Grünzweig, J.M., Gya, R., Hansen, K., Jentsch, A., Lee, H., Linder, S., Marshall, J., Peñuelas, J., Kappel, Schmidt, I., Stuart-Haëntjens, E., Wilfahrt, P., Vandvik, V., Abrantes, N., Almagro, M., Althuizen, I.H.J., Barrio, I.C., Te, Beest, M., Beier, C., Beil, I., Carter, Berry, Z., Birkemoe, T., Bjerke, J.W., Blonder, B., Blume-Werry, G., Bohrer, G., Campos, I., Cernusak, L.A., Chojnicki, B.H., Cosby, B.J., Dickman, L.T., Djukic, I., Filella, I., Fuchslueger, L., Gargallo-Garriga, A., Gillespie, M.A.K., Goldsmith, G.R., Gough, C., Halliday, F.W., Hegland, S.J., Hoch, G., Holub, P., Jaroszynska, F., Johnson, D.M., Jones, S.B., Kardol, P., Keizer, J.J., Klem, K., Konestabo, H.S., Kreyling, J., Kröel-Dulay, G., Landhäusser, S.M., Larsen, K.S., Leblans, N., Lebron, I., Lehmann, M.M., Lembrechts, J.J., Lenz, A., Linstädter, A., Llusià, J., Macias-Fauria, M., Malyshev, A.V., Mänd, P., Marshall, M., Matheny, A.M., McDowell, N., Meier, I.C., Meinzer, F.C., Michaletz, S.T., Miller, M.L., Muffler, L., Oravec, M., Ostonen, I., Porcar Castell, Albert, Preece, C., Prentice, I.C., Radujkovic, D., Ravolainen, V., Ribbons, R., Ruppert, J.C., Sack, L., Sardans, J., Schindlbacher, A., Scoffoni, C., Sigurdsson, B.D., Smart, S., Smith, S.W., Soper, F., Speed, J.D.M., Sverdrup-Thygeson, A., Sydenham, M.A.K., Taghizadeh-Toosi, A., Telford, R.J., Tielbörger, K., Töpper, J.P., Urban, O., Van der, Ploeg, M., Van Langenhove, L., Vecerová, K., Ven, A., Verbruggen, E., Vik, U., Weigel, R., Wohlgemuth, T., Wood, L.K., Zinnert, J., Zurba, K., and the, ClimMani, Working, Group

Abstract

Climate change is a world-wide threat to biodiversity and ecosystem structure, functioning and services. To understand the underlying drivers and mechanisms, and to predict the consequences for nature and people, we urgently need better understanding of the direction and magnitude of climate change impacts across the soil plant atmosphere continuum. An increasing number of climate change studies are creating new opportunities for meaningful and high-quality generalizations and improved process understanding. However, significant challenges exist related to data availability and/or compatibility across studies, compromising opportunities for data re-use, synthesis and upscaling. Many of these challenges relate to a lack of an established best practice for measuring key impacts and responses. This restrains our current understanding of complex processes and mechanisms in terrestrial ecosystems related to climate change. To overcome these challenges, we collected best-practice methods emerging from major ecological research networks and experiments, as synthesized by 115 experts from across a wide range of scientific disciplines. Our handbook contains guidance on the selection of response variables for different purposes, protocols for standardized measurements of 66 such response variables and advice on data management. Specifically, we recommend a minimum subset of variables that should be collected in all climate change studies to allow data re-use and synthesis, and give guidance on additional variables critical for different types of synthesis and upscaling. The goal of this community effort is to facilitate awareness of the importance and broader application of standardized methods to promote data re-use, availability, compatibility and transparency. We envision improved research practices that will increase returns on investments in individual research projects, facilitate second-order research outputs and create opportunities for collaboration across scientific

Published
2020

24. The International Soil Modeling Consortium (ISMC) New opportunities for advancing data and modeling of soil systems

Author

Baatz, Roland, Tarquis, A. M., Young, M., Ghezzehei, T., Vereecken, Harry, Verhoef, A., Painter, S., Mishra, U., Simunek, J., Vanderborght, Jan, Wollschläger, U., Or, D., and van der Ploeg, M.

Abstract

The International Soil Modeling Consortium (ISMC) was established in 2016 with the aim to integrate and advance soil systems modeling, data collection, and observational capabilities. ISMC is a community effort accepting members from all fields (https://soil-modeling.org/). Its activities are organized around three science panels: data and observation model linking (DO-LINK), soil modeling development and intercomparison (Soil-MIP), and cross cutting activities (CROSS-Connect). ISMC fosters development of new soil models for quantifying soil functions and their changes with land use, climate and degradation. Recently, a number of model intercomparison studies have been initiated, focusing on specific processes such as root growth and water uptake, soil evaporation, soil freezing, soil heat fluxes, infiltration and runoff processes, and the coupling of soil preferential flow with groundwater. ISMC is coordinating efforts to form a global soil data meta-repository that will be openly available for soil systems research. The meta-repository will be a resource to analyze past and recent model- and data requirements for continuous standardization and harmonization of soil data. ISMC also seeks to identify soil related knowledge gaps between science communities, and to share this knowledge with neighbouring disciplines to better translate soil processes into functions for assessing sustainability and ecosystem services. Finally, ISMC is involved in creating exchange platforms with other international partners like AgMip/MACSUR, GEWEX, ISCN (International Soil Carbon Network), and GSBI (Global Soil Biodiversity Initiative). In this presentation, we will highlight recent developments and activities and present future plans for engaging young scientists and communicating soil modelling with other disciplines and the public.

Published
2019

28. Twenty-three unsolved problems in hydrology (UPH)–a community perspective

Author

Blöschl, G., Bierkens, M. F. P., Chambel, A., Cudennec, C., Destouni, G., Fiori, A., Kirchner, J. W., McDonnell, J. J., Savenije, H. H. G., Sivapalan, M., Stumpp, C., Toth, E., Volpi, E., Carr, G., Lupton, C., Salinas, J., Széles, B., Viglione, A., Aksoy, H., Allen, S. T., Amin, A., Andréassian, V., Arheimer, B., Aryal, S. K., Baker, V., Bardsley, E., Barendrecht, M. H., Bartosova, A., Batelaan, O., Berghuijs, W. R., Beven, K., Blume, T., Bogaard, T., Borges de Amorim, P., Böttcher, M. E., Boulet, G., Breinl, K., Brilly, M., Brocca, L., Buytaert, W., Castellarin, A., Castelletti, A., Chen, X., Chen, Y., Chifflard, P., Claps, P., Clark, M. P., Collins, A. L., Croke, B., Dathe, A., David, P. C., de Barros, F. P. J., de Rooij, G., Di Baldassarre, G., Driscoll, J. M., Duethmann, D., Dwivedi, R., Eris, E., Farmer, W. H., Feiccabrino, J., Ferguson, G., Ferrari, E., Ferraris, S., Fersch, B., Finger, D., Foglia, L., Fowler, K., Gartsman, B., Gascoin, S., Gaume, E., Gelfan, A., Geris, J., Gharari, S., Gleeson, T., Glendell, M., Gonzalez Bevacqua, A., González-Dugo, M. P., Grimaldi, S., Gupta, A. B., Guse, B., Han, D., Hannah, D., Harpold, A., Haun, S., Heal, K., Helfricht, K., Herrnegger, M., Hipsey, M., Hlaváčiková, H., Hohmann, C., Holko, L., Hopkinson, C., Hrachowitz, M., Illangasekare, T. H., Inam, A., Innocente, C., Istanbulluoglu, E., Jarihani, B., Kalantari, Z., Kalvans, A., Khanal, S., Khatami, S., Kiesel, J., Kirkby, M., Knoben, W., Kochanek, K., Kohnová, S., Kolechkina, A., Krause, S., Kreamer, D., Kreibich, H., Kunstmann, H., Lange, H., Liberato, M. L. R., Lindquist, E., Link, T., Liu, J., Loucks, D. P., Luce, C., Mahé, G., Makarieva, O., Malard, J., Mashtayeva, S., Maskey, S., Mas-Pla, J., Mavrova-Guirguinova, M., Mazzoleni, M., Mernild, S., Misstear, B. D., Montanari, A., Müller-Thomy, H., Nabizadeh, A., Nardi, F., Neale, C., Nesterova, N., Nurtaev, B., Odongo, V. O., Panda, S., Pande, S., Pang, Z., Papacharalampous, G., Perrin, C., Pfister, L., Pimentel, R., Polo, M. J., Post, D., Prieto Sierra, C., Ramos, M. -H, Renner, M., Reynolds, J. E., Ridolfi, E., Rigon, R., Riva, M., Robertson, D. E., Rosso, R., Roy, T., Sá, J.H.M., Salvadori, G., Sandells, M., Schaefli, B., Schumann, A., Scolobig, A., Seibert, J., Servat, E., Shafiei, M., Sharma, A., Sidibe, M., Sidle, R. C., Skaugen, T., Smith, H., Spiessl, S. M., Stein, L., Steinsland, I., Strasser, U., Su, B., Szolgay, J., Tarboton, D., Tauro, F., Thirel, G., Tian, F., Tong, R., Tussupova, K., Tyralis, H., Uijlenhoet, R., van Beek, R., van der Ent, R. J., van der Ploeg, M., Van Loon, A. F., van Meerveld, I., van Nooijen, R., van Oel, P. R., Vidal, J. -P, von Freyberg, J., Vorogushyn, S., Wachniew, P., Wade, A. J., Ward, P., Westerberg, I. K., White, C., Wood, E. F., Woods, R., Xu, Z., Yilmaz, K. K., Zhang, Y., Blöschl, G., Bierkens, M. F. P., Chambel, A., Cudennec, C., Destouni, G., Fiori, A., Kirchner, J. W., McDonnell, J. J., Savenije, H. H. G., Sivapalan, M., Stumpp, C., Toth, E., Volpi, E., Carr, G., Lupton, C., Salinas, J., Széles, B., Viglione, A., Aksoy, H., Allen, S. T., Amin, A., Andréassian, V., Arheimer, B., Aryal, S. K., Baker, V., Bardsley, E., Barendrecht, M. H., Bartosova, A., Batelaan, O., Berghuijs, W. R., Beven, K., Blume, T., Bogaard, T., Borges de Amorim, P., Böttcher, M. E., Boulet, G., Breinl, K., Brilly, M., Brocca, L., Buytaert, W., Castellarin, A., Castelletti, A., Chen, X., Chen, Y., Chifflard, P., Claps, P., Clark, M. P., Collins, A. L., Croke, B., Dathe, A., David, P. C., de Barros, F. P. J., de Rooij, G., Di Baldassarre, G., Driscoll, J. M., Duethmann, D., Dwivedi, R., Eris, E., Farmer, W. H., Feiccabrino, J., Ferguson, G., Ferrari, E., Ferraris, S., Fersch, B., Finger, D., Foglia, L., Fowler, K., Gartsman, B., Gascoin, S., Gaume, E., Gelfan, A., Geris, J., Gharari, S., Gleeson, T., Glendell, M., Gonzalez Bevacqua, A., González-Dugo, M. P., Grimaldi, S., Gupta, A. B., Guse, B., Han, D., Hannah, D., Harpold, A., Haun, S., Heal, K., Helfricht, K., Herrnegger, M., Hipsey, M., Hlaváčiková, H., Hohmann, C., Holko, L., Hopkinson, C., Hrachowitz, M., Illangasekare, T. H., Inam, A., Innocente, C., Istanbulluoglu, E., Jarihani, B., Kalantari, Z., Kalvans, A., Khanal, S., Khatami, S., Kiesel, J., Kirkby, M., Knoben, W., Kochanek, K., Kohnová, S., Kolechkina, A., Krause, S., Kreamer, D., Kreibich, H., Kunstmann, H., Lange, H., Liberato, M. L. R., Lindquist, E., Link, T., Liu, J., Loucks, D. P., Luce, C., Mahé, G., Makarieva, O., Malard, J., Mashtayeva, S., Maskey, S., Mas-Pla, J., Mavrova-Guirguinova, M., Mazzoleni, M., Mernild, S., Misstear, B. D., Montanari, A., Müller-Thomy, H., Nabizadeh, A., Nardi, F., Neale, C., Nesterova, N., Nurtaev, B., Odongo, V. O., Panda, S., Pande, S., Pang, Z., Papacharalampous, G., Perrin, C., Pfister, L., Pimentel, R., Polo, M. J., Post, D., Prieto Sierra, C., Ramos, M. -H, Renner, M., Reynolds, J. E., Ridolfi, E., Rigon, R., Riva, M., Robertson, D. E., Rosso, R., Roy, T., Sá, J.H.M., Salvadori, G., Sandells, M., Schaefli, B., Schumann, A., Scolobig, A., Seibert, J., Servat, E., Shafiei, M., Sharma, A., Sidibe, M., Sidle, R. C., Skaugen, T., Smith, H., Spiessl, S. M., Stein, L., Steinsland, I., Strasser, U., Su, B., Szolgay, J., Tarboton, D., Tauro, F., Thirel, G., Tian, F., Tong, R., Tussupova, K., Tyralis, H., Uijlenhoet, R., van Beek, R., van der Ent, R. J., van der Ploeg, M., Van Loon, A. F., van Meerveld, I., van Nooijen, R., van Oel, P. R., Vidal, J. -P, von Freyberg, J., Vorogushyn, S., Wachniew, P., Wade, A. J., Ward, P., Westerberg, I. K., White, C., Wood, E. F., Woods, R., Xu, Z., Yilmaz, K. K., and Zhang, Y.

Abstract

QC 20210112

Published
2019
Full Text
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30. Bodemvocht uit satellietdata: wat kan de Nederlandse waterbeheerder ermee?

Author

van der Velde, R., Benninga, H.J., Pezij, M., Augustijn, D., Carranza, C., van der Ploeg, M., and Hendriks, D.

Subjects
Soil Physics and Land Management, WIMEK, Bodemfysica en Landbeheer
Abstract

Het onderzoeksproject ‘Optimizing Water Availability with Sentinel-1 Satellites’ heeft als doel te onderzoeken hoe satellietdata gebruikt kan worden in het Nederlandse waterbeheer. Het onderzoek laat zien dat de satelliet Sentinel-1 buiten het groeiseizoen om al een vrij goed beeld geeft van het bodemvochtgehalte. Hiermee kan bijvoorbeeld de berijdbaarheid van landbouwpercelen in kaart gebracht kan worden. Ook is met Deltares en HKV een data-assimilatietool ontwikkeld die ingezet kan worden om simulaties met het Landelijk Hydrologisch Model te verbeteren.

Published
2018

31. Evaluatie MKB Innovatiestimuleringsregeling Topsectoren (MIT), 2013-2016

Author

Zuijdam, F., Ploeg, M., Schipper, J., Vermeer, J., van der Werff, S., Zwetsloot, J., Faculteit Economie en Bedrijfskunde, and SEO Economisch Onderzoek

Abstract

Specifiek voor het mkb heeft de overheid in 2013 de MKB Innovatiestimuleringsregeling Topsectoren (MIT) gelanceerd. De doelstelling van de MIT is het bevorderen van innovatie bij het mkb en om het mkb beter te laten aansluiten bij de door de Topsectoren opgestelde innovatie-agenda's. De MIT omvat verschillende subsidie-instrumenten, waarvan kennisvouchers, R&D-samenwerkingsprojecten en haalbaarheidsprojecten de omvangrijkste zijn. De MIT-regeling formeel per 1 maart 2018. In het kader van de Rijksbrede regeling voor Periodiek Evaluatieonderzoek en met het oog op een eventuele verlenging van de regeling heeft het ministerie van EZ Technopolis Group en SEO Economisch Onderzoek opdracht gegeven om een onafhankelijke evaluatie van de MIT-regeling voor de periode 2013 – 2016 uit te voeren. SEO heeft hierbij de econometrische analyse op basis van de adviezen van de commissie-Theeuwes uitgevoerd. Uit deze evaluatie blijkt dat er in het algemeen geen grote knelpunten zijn. De doelgroep van de MIT blijken in de ruim de helft van de gevallen zeer kleine bedrijven te zijn, dit zijn zowel starters als langer bestaande bedrijven. Het is nog te vroeg om iets te kunnen zeggen over de harde economische resultaten, omdat nog niet alle MIT-projecten zijn afgelopen en het soms ook enige tijd duurt voordat economische resultaten optreden. Wel wijzen de resultaten op additionele investeringen in innovatie van deelnemers als gevolg van deelname aan de MIT. Aanbevolen in het rapport wordt om de MIT-regeling voort te zetten na 2018.

Published
2017

32. Thoracic Aortic Rupture and Aortopulmonary Fistulation in the Friesian Horse

Author

Ploeg, M, Saey, V, Delesalle, C, Gröne, A, Ducatelle, R, de Bruijn, M, Back, W, van Weeren, P R, van Loon, G, Chiers, K, ES AVM, ES TR, Veterinair Pathologisch Diagnostisch Cnt, LS Equine Internal Medicine, LS Pathologie, LS Heelkunde, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, dPB CR, Regenerative Medicine, Stem Cells & Cancer, dPB I&I, dES AVR, dES RMSC, ES AVM, ES TR, Veterinair Pathologisch Diagnostisch Cnt, LS Equine Internal Medicine, LS Pathologie, LS Heelkunde, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, dPB CR, Regenerative Medicine, Stem Cells & Cancer, dPB I&I, dES AVR, and dES RMSC

Subjects
Male, Marfan syndrome, Pathology, medicine.medical_specialty, Aortic Rupture, Pulmonary Artery, aortopulmonary fistulation, histology, Arterio-Arterial Fistula, Fibrosis, medicine.artery, Ascending aorta, medicine, Animals, vasa vasorum, Horses, Aortic rupture, Aorta, Friesian horses, General Veterinary, biology, business.industry, Vasa Vasorum, pseudoaneurysm, Anatomy, medicine.disease, Immunohistochemistry, aorta, medicine.anatomical_structure, Vasa vasorum, immunohistochemistry, laminar medial necrosis, biology.protein, Female, Horse Diseases, Smooth muscle hypertrophy, business, Elastin, Aneurysm, False
Abstract

Aortic rupture in horses is a rare condition. Although it is relatively common in the Friesian breed, only limited histopathologic information is available. Twenty Friesian horses (1–10 years old) were diagnosed with aortic rupture by postmortem examination. Ruptured aortic walls were analyzed with histology and immunohistochemistry. Based on the histologic and immunohistochemical findings, these cases were divided into 3 groups: acute ( n = 4, 20%), subacute ( n = 8, 40%), and chronic ( n = 8, 40%). Features common to samples from horses in all groups included accumulation of mucoid material; disorganization and fragmentation of the elastic laminae; aortic medial smooth muscle hypertrophy; and medial necrosis of varying degrees, ranging from mild and patchy in the acute cases to severe midzonal necrosis in the chronic cases. Inflammation, most likely secondary to medial necrosis, varied from predominantly neutrophilic infiltrates in the media and periadventitial tissue in the acute group to the presence of mainly hemosiderophages in the periadventitial tissue in the chronic group. Medial fibrosis with aberrant collagen morphology was seen in the subacute group and, more commonly, in the chronic group. Only minimal changes were seen in the aortic vasa vasorum. Smooth muscle hypertrophy and accumulation of mucoid material were not related to the age of the lesions. The findings of this study suggest that a connective tissue disorder affecting elastin or collagen in the aortic media is potentially the underlying cause of aortic rupture in Friesian horses.

Published
2014
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33. Bodemvocht uit satellietdata: wat kan de Nederlandse waterbeheerder ermee?

Author

Velde, R. van der, Benninga, H.-J., Pezij, M., Augustijn, D., Carranza, C., Ploeg, M. van der, Hendriks, D., Velde, R. van der, Benninga, H.-J., Pezij, M., Augustijn, D., Carranza, C., Ploeg, M. van der, and Hendriks, D.

Abstract

Het onderzoeksproject ‘Optimizing Water Availability with Sentinel-1 Satellites’ heeft als doel te onderzoeken hoe satellietdata gebruikt kan worden in het Nederlandse waterbeheer. Het onderzoek laat zien dat de satelliet Sentinel-1 buiten het groeiseizoen om al een vrij goed beeld geeft van het bodemvochtgehalte. Hiermee kan bijvoorbeeld de berijdbaarheid van landbouwpercelen in kaart gebracht kan worden. Ook is met Deltares en HKV een data-assimilatietool ontwikkeld die ingezet kan worden om simulaties met het Landelijk Hydrologisch Model te verbeteren.

Published
2018

34. ILT onder de loep

Author

Wiegel, J., Ploeg, M., Wiegel, J., and Ploeg, M.

Abstract

De laatste tijd haalde ILT regelmatig het (pluimvee)nieuws in verband met uitbraken in Nederland. Wat is ILT nou eigenlijk precies en hoe uit het zich in de kip? En hoe kun je zo’n uitbraak vaststellen?

Published
2018

36. Abstracts of Selected Posters

Author

Albanese, R., Antoine, J. L., Dutrillaux, B., Ashley, T., Avivi, L., Kariv, I., Barigozzi, C., Baratelli, L., Profeta, S., Bartram, C. R., de Klein, A., Hagemeijer, A., Grosveld, G., Bootsma, D., Bennett, Michael D., Smith, J. B., Ward, J. P., Heslop-Harrison, J. S., Blin, N., Kopun, M., Buys, C. H. C. M., Koerts, T., van der Veen, A. Y., de Leij, L., Civitelli, M. V., Capanna, E., Couturier, J., Arnason, U., Mandahl, N., Créau-Goldberg, N., Turleau, C., Cochet, C., de Grouchy, J., Dietrich, A. J. J., Delhanty, J. D. A., Mazzullo, H. A., Cooke, H. M. G., Dotan, A., Dresser, M. E., Moses, M. J., Evans, E. P., Burgoyne, P. B., Ferraro, M., Lavia, P., Fonatsch, C., Kirchner, H. H., Pajunk, A., Schaadt, M., Burrichter, H., Diehl, V., Ford, J. H., Roberts, C. G., Friebe, B., Vogel, R., Friedländer, M., Gamperl, R., Amtmann, E., Pfister, H., Gebhart, E., Wagner, H., Goetz, P., Chandley, A. C., Speed, R. M., Goyanes, V. J., Schvartzman, J. B., Graeven, U., Weh, H. J., Hossfeld, D. K., Greenblatt, I. M., Gripenberg, U., Söderlund, V., Wahlberg, C., Blomqvist, L., Guichaoua, M. R., Delafontaine, D., Taillemite, J. L., Luciani, J. M., Naaf, T., Grunert, D., Schmid, M., Hameister, H., Sperling, K., Hamers, A., Jongbloet, P., Peeters, G., Geraedts, J., Hartley-Asp, B., Heneen, W. K., Hens, L., Kirsch-Volders, M., Susanne, C., Herbst, E. W., Winking, H., Claussen, C. P., Putz, B., Sellin, D., Kolbus, U., Gropp, A., Bennett, M. D., Heyting, C., Koperdraad, F., Redeker, E. J. W., Holmquist, G., Goldman, M., Jaworska, Halina, Johannisson, R., Kerem, B., Goitein, R., Richier, C., Marcus, M., Cedar, H., Koch, H., Hoehn, H., Kubbies, Manfred, Rabinovitch, Peter S., Kunz, W., Franz, G., Lacadena, J. R., Cermeno, M. C., Orellana, J., Santos, J. L., Lemeunier, F., Derbin, C., Lin, C. C., Hoar, D. I., Hoo, J. J., Macgregor, H. C., Sims, S., Horner, H. A., Pellatt, P., Mackay, J. M., Fox, D. P., Brunt, P. W., Johnston, A. W., Magenis, R. E., Chamberlin, J., Allen, L., Tomar, D., Olson, S., Donlon, T., Marlekaj, P., Balcini, A., Fantoni, A., de Capoa, A., Martinsson, T., Dahllöf, B., Levan, G., Matsukuma, S., Utakoji, T., del Mazo, J., Avila, J., Miller, D. A., Feinstein, S. I., Miller, O. J., Morita, T., Delarbre, C., Gachelin, G., Kourilsky, P., Moritz, K., Moriwaki, K., Miyashita, N., Imai, H. T., Wang, C. H., Bonhomme, F., Murer-Orlando, M., Peterson, A. C., Neitzel, H., Bogenberger, J., Fittler, F., Gaenge, M., Schulze, C., Nietzel, H., Nürnberger, F., Höhn, H., van Ommen, G. J. B., Baas, F., Arnberg, A. C., Pearson, P. L., De Vijilder, J. J. M., Bakker, E., Hofker, M., Wapenaar, M. C., Parrington, J. M., West, L. F., Povey, S., Pasquali, F., Casalone, R., Bernasconi, P., Paul, J., Froster-Iskenius, U., Schwinger, E., Moje, W., Pearson, P. O., Beverstock, G. C., Veenema, H., v.d Kamp, J. J., Petitpierre, E., Philip, J., Lundsteen, C., van der Ploeg, M., van Prooijen-Knegt, A. C., Bauman, J. G. J., van Duijn, P., Puertas, M. J., de la Pena, A., Estades, B., Merino, F., Rao, S. R. V., Vasantha, K., Thelma, B. K., Juyal, R. C., Jhanwar, S. C., Ratomponirina, Ch, Hamilton, A., Rumpler, Y., Moses, M., Raveh, D., Ben-Zeoev, A., Redi, C. A., Garagna, S., Italy, C. N. R., Robert-Nicoud, M., Streichhan, I., Möhr, E., Westermann, R., Grossbach, U., Sandberg, P., Levan, A., Schäfer, Mireille, Schempp, W., Scheres, J. M. J. C., Hustinx, T. W. J., Holdrinet, R. S. G., Tice, R. R., Schwarzacher, T., Finch, R. A., Searle, J. B., Sharma, T., Sen, S., Cheong, N., Siebert, E., Loidl, J., Slater, R. M., de Kraker, J., Voute, P. A., Delemarre, J. F. M., Smeets, D. F. C. M., Smits, A. P. T., Solleder, E., Inglin, B., Geile, B., Somssich, I., Schwarz, E., Speit, G., Mehnert, K., Vogel, W., Stahl, A., Hartung, M., Devictor, M., Guichaoua, M., Stoll, C., Roth, M.-P., Dott, B., Tabor, A., Madsen, M., Tommerup, N., Traut, W., Chavin-Colin, F., Junien, C., Vekemans, M., Esseltine, D., Venegas, W., Lasne, Cl, Chouroulinkov, I., Vidal, F., Navarro, J., Templado, C., Egozcue, J., Viegas-Péquignot, E., Malfoy, B., Taillandier, E., Leng, M., Viinikka, Y., Spielmann, H., Boldin, S., Volobouev, V. T., Webb, G. C., Krumins, E., Wegner, R.-D., Lüdtke, E.-L., Weith, A., Westerman, M., Thomson, R., Sinclair, A., Yacobi, Y. Z., Feldman, M., Yoon, J. S., Bennett, M. D., editor, Gropp, A., editor, and Wolf, U., editor

Published
1984
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38. Enzymes

Author

Tsou, K. C., Reale, Enrico, Luciano, Liliana, van der Ploeg, M., van Duijn, P., Persijn, J.-P., Daems, W. Th., Rosa, Charles G., Fasske, Erhard, Steins, Ingeborg, Themann, Hermann, Schulze, W., Wollenberger, A., Sommer, Joachim R., Blum, Jacob J., McCabe, Mary, Stock, Aaron H., Schiebler, T. H., editor, Pearse, A. G. E., editor, and Wolff, H. H., editor

Published
1964
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39. Third International Congress of Histochemistry and Cytochemistry

Author

Abe, Muneaki, Akamatsu, Masasuke, Matsumoto, Takaharu, Ohuchi, Nobuo, Masuya, Tomichi, Abe, T., Nakashio, K., Kazama, M., Matsuda, M., Adams, C. W. M., Virág, S., Morgan, R. S., Orton, C. C., Adams, Jean R., Wilcox, Theodore A., Akert, Konrad, Alberti, Rachele, Allen, Robert C., Moore, Dorothy J., Tyndall, Richard L., Anderson, Paul J., Song, Sun K., Angelakos, E. T., King, M. P., Appleton, Timothy C., Arstila, Antti U., Trump, Benjamin F., Lauria, A., Bahr, Gunter F., Wied, George L., Bartels, Peter H., Bajusz, E., Balogh, Kåroly, Barer, R., Barka, Tibor, Barnard, Eric A., Komender, Janusz, Wieckowski, Jan, Barrnett, R. J., Barron, K. D., Koeppen, A. H., Bernsohn, J., Bélanger, Leonard F., Beltrami, Carlo Alberto, Björklund, A., Ehinger, B., Falck, B., Boadle, Margaret C., Bloom, Floyd E., Bona, C., Bradshaw, M., Monus, L., Stroman, S., Budd, G. C., Salpeter, M. M., Bukhonova, A. I., Burnasheva, S. A., Jurzina, G. A., Burt, Alvin M., Chang, Jeffrey P., Schatzki, Peter F., Saito, Takuma, Chavin, Walter, Chyle, M., Korych, B., Lojda, Zdenek, Patocka, F., Cohn, Z. A., Conning, D. M., Coutinho, Hélio B., Rocha, Jácia T., Jales, Benjamin F., Cunningham, Lew, Heitsch, Richard, Daneholt, B., Edström, J.-E., Danilova, L. V., Rokhlenko, K. D., Dauwalder, M., Whaley, W. G., Kephart, J. E., Deitch, Arline D., Sawicki, Stanley G., Godman, Gabriel C., Della Corte, Francesco, Desmet, V. J., Bullens, A.-M., De Groote, J., Heirwegh, K. P. M., Diculescu, I., Onicescu, Doina, Szegly, G., Doane, Winifred W., Donskikh, N. V., Novikov, V. D., Subbotin, M. Ya., Tsirelnikov, N. I., Doolin, Paul F., Birge, Wesley J., Droz, Bernard, Bergeron, M., Drukker, J., Duarte-Escalante, Ovidio, Dubowitz, Victor, Dupraw, E. J., Eckner, Friedrich A. O., Blackstone, Eugene H., Moulder, Peter V., Ehrlich, M. P., Ellis, Stanley, McDonald, J. Ken, Callahan, P. X., Enesco, Hildegard E., Engel, W. King, Epifanova, O. I., Lomakina, L. Ya., Terskikh, V. V., Ericsson, Jan L. E., Jakobsson, Sten, Eristawi, K. D., Sharashidze, L. K., Sturua, N. S., Fabris, Guidalberto, Mariuzzi, Gianmario, Nenci, Italo, Fahimi, H. Dariush, Karnovsky, Morris J., Fand, Sally B., Farquhar, Marilyn G., Felgenhauer, K., Glenner, G. G., Stammler, A., Filkuka, J., Svejda, J., Áubrechtova, V., Filotto, U., Fischbein, J. W., Rutenburg, Alexander M., Fisher, Donald B., Forni, Alessandra, Nencioni, Torquato, Ballare’, Gianfranco, Fotin, Ludmila, Popescu, Maria, Frankfurt, O. S., Friend, Daniel S., Fuchs, B. B., Arutyunov, V. D., Shnaper, A. L., Gabunia, U. A., Shiukashvili, N. N., Gahan, P. B., Anker, P., Stroun, M., McLean, Jean, Galjaard, H., Bootsma, D., Ganina, K. P., Garcia, Alfredo Mariano, Garrett, J. R., Gepts, W., Gregoire, F., Ooms, H., Gerzeli, Giuseppe, Giacobini, Ezio, Hovmark, Stefan, Gilkerson, Seth W., Glick, David, Godlewski, H. G., Huszczuk, A., Penar, Barbara, Goldfischer, Sidney, Sternlieb, Irmin, Goldstone, A., Szabo, E., Koenig, Harold, Gornak, K. A., Goslar, H. G., Grigoriadis, P., Jaeger, K. H., Gössner, W., Benoit, H., Gracheva, Nina D., Grillo, T. Adesanya Ige, Gropp, A., Gross, U. M., Gueft, Boris, Guha, S., Fouquet, J. P., Håkanson, R., Owman, Ch., Sporrong, B., Hale, A. J., Marshall, D. J., Switsur, V. R., Hanker, Jacob S., Zenker, Nicolas, Morizono, Yoshihisa, Deb, Chandicharan, Seligman, Arnold M., Hardonk, M. J., Elema, J. D., Koudstaal, Joh., Hoedemaeker, Ph. J., Hayashi, Masando, Heller, A., Hernández, F., Martinez De Morentin, J., Herrmann, Hans-Jürgen, Hershey, Falls B., Hess, H. H., Pope, A., Bass, N. H., Hewitt, J. M., Guigon, M., Bolubasz, J., Himes, M. H., Burdick, C., Hirai, Kei-Ichi, Takamatsu, Hideo, Hirose, Shunta, Hirsch, Hilde E., Hodges, Donald R., Costoff, Allen, McShan, W. H., Holtzman, Eric, Holubar, K., Tappeiner, J., Wolff, K., Hopsu-Havu, Väinö K., Hosannah, Yvonne, Blackwood, Carlton E., Mandl, Ines, Hoskins, Godfrey C., Hugon, J. S., Borgers, M., Hurwitz, Lawrence S., Rubinstein, Lucien J., Ibrahim, M. Z. M., Imura, Shin-Ichi, Takeda, Masanori, Jacobsen, N. O., Jørgensen, P. Leth, Jarrett, A., Joandrea-Casian, Claudia, Prundeanu, Cornelia, Johnson, Anne B., Johnson, Waine C., Alkek, David S., Jongkind, J. F., Swaab, D. F., Jos, J., Junqueira, L. C., Toledo, A. M. Souza, Kaiser, Hans E., Kakari, Sophia, Kalina, Moshe, Bubis, Jose. J., Kamentsky, L. A., Kasten, Frederick H., Kiefer, Gunter G., Sandritter, W., Killander, D., Rigler, R., Kishino, Yasuo, Kobayashi, H., Urano, A., Yokoyama, K., Koelle, George B., Hughes, Charles, Korhonen, L. Kalevi, Kramer, M. F., Poort, C., Kreutzberg, Georg W., Künzel, Erich, Tanyolac, Attila, Labella, Frank S., Langley, O. K., Lanza, Giovanni B., Lappano-Colletta, Eleanor Rita, Leblond, C. P., Merzel, J., Cheng, Hazel, Nadler, N. J., Herscovics, Annette A., Lederer, B., Mittermayer, C., Lee, Sin Hang, Torack, Richard M., Lehrer, Gerard M., Bornstein, Murray B., Katzman, Robert, Leites, F. L., Tendetnik, Ju. J., Ruchadse, E. S., Rjadneva, O. E., Leppi, T. John, Kinnison, Patricia A., Gaffney, Susan P., Lev, Robert, Gerard, Andre, De Graef, Jacques, Jerzy Glass, George B., Lhotka, J. F., Jr., Anderson, J. W., Liber, Amour F., Lillie, R. D., Pizzolato, Philip, Lindner, J., Grasedyck, K., Johannes, G., Freytag, G., Lipchina, L. P., Aksyutina, M. S., Yablonovskaya, L. Ya., Lipetz, Jacques, Liu, J. C., Roizin, L., Lodin, Z., Kage, M., Hartman, J., Srajer, J., Fric, Premysl, Long, Margaret E., Sommers, Sheldon C., McGarry, E. E., Nayak, R., Birch, E., Beck, J. C., McMillan, Paul J., Adeoye, Christopher ’Seinde, Macovschi, O., Maeda, Ryuei, Ihara, Nobuo, Kanazawa, Kokichi, Maeir, David M., Wagner, Lenore, Maggi, Viviane, Franks, L. M., Livingston, D. C., Coombs, M. M., Wilson, Patricia D., Carbonell, A. W., Malyuk, V. I., Romanini, Manfredi, Gabriella, Maria, Fraschini, Annunzia, Porcelli, Franca, Manocha, Sohan L., Shantha, Totada R., Bourne, Geoffrey H., Marques, Dante, Bastos, A. L., Baptista, A. M., Vigario, J. D., Nunes, J. M., Terrinha, A. M., Silva, J. A. F., Masurovsky, E. B., Benitez, H. H., Kim, S-U., Murray, M. R., Matschinsky, F. M., Rutherford, C. L., Guerra, L., Matturri, L., Curri, S., Melnick, P. J., Mendelsohn, M. L., Conway, T. J., Perry, B., Prewitt, J. M. S., Mercado, Teresa I., Miksche, Jerome P., Misch, Donald W., Misch, Margaret S., Mitchell, J. P., Mizuhira, Vinci, Uchida, Kazuko, Amakawa, Takanori, Shindo, Hideo, Totsu, Junichi, Suesada, Ikuo, Mizutani, Akira, Monis, Benito, Candiotti, Alberto, Mori, G., Ingrami, A., Morikawa, Shigeru, Yamamura, Masao, Harada, Takayuki, Hamashima, Yoshihiro, Mullaney, P. F., Dean, P. N., Van Dilla, M. A., Müller, Gerhard, Müller, Otfried, Nakane, Paul K., Neurath, Peter W., Curtis, Zay B., Selles, William, Vetter, Henri G., Norgren, P. E., Novikoff, Alex B., O’Brien, Regina, Ohringer, Philip, Spitaleri, Vincent, Olszewska, M. J., Gabara, B., Konopska, L., Parfanovich, M. I., Sokolov, N. N., Berezina, O. N., Fadeeva, L. L., Pauly, John E., Scheving, Lawrence E., Pearse, A. G. E., Pearson, Bjarne, Bennett, William, Esterly, John R., Standen, Alfred C., Pelc, S. R., Viola-Magni, M. P., Penttilä, Antti, Perez, Vernon J., Moore, Blake W., Peters, Theodore, Jr., Danzi, J. Thomas, Ashley, Charles A., Petrova, A. S., Probatova, N. A., Philippens, Karel, Pilgrim, C., Pollock, B. M., Presnov, M. A., Preston, Kendall, Jr., Preto Parvis, V., Cisotti, F., Prewitt, Judith M. S., Mayall, Brian H., Mendelsohn, Mortimer L., Pryse-Davis, John, Sandler, Merton, Quay, W. B., Raikhlin, N. T., Rasch, Ellen M., Riecken, E. O., Goebell, H., Bode, C., Rigatuso, Joseph L., Ringertz, N. R., Bolund, L., Ritter, Carl, Thorell, Bo, Rizzotti, M., Aureli, G., Balduini, C., Castellani, A. A., Rosenbaum, Robert M., Rosene, Gordon L., Rossi, Ferdinando, Rost, F. W. D., Roth, Daniel, Ruch, Fritz, Ruddle, Frank H., Lubs, Herbert A., Ledley, Robert S., Shows, Thomas B., Roderick, Thomas H., Kim, H., Brodie, E., Rosales, C. L., Sadauskas, P., Luksys, L., Dabkevcius, V., Sakharova, A. V., Sakharov, D. A., Samosudova, N. V., Ogieveckaja, M. M., Kalamkarova, M. B., Sandler, Maurice, Santti, R. S., Sasaki, Mitsuo, Takeuchi, Tadao, Satir, P., Schauer, Alfred, Scher, Stanley, Haley, Patricia L., Schiebler, T. H., Schiemer, Hans-Georg, Schlüns, Jürgen, Schuster, F. L., Hershenov, B., Scott, J. E., Scott, T. Gilbert, Seno, Satimaru, Yokomura, Ei-Ichi, Itoh, Nobutaka, Yamamoto, Michio, Shungskaya, V. E., Enenko, S. O., Lukyanova, L. D., Sarch, E. N., Shuter, Eli, Jungalwala, Firoze, Robins, Eli, Sierakowska, Halina, Silverman, L., Simard, A., Daoust, R., Smith, Edgar E., Smith, R. E., Fishman, William H., Henzl, Milan, Sobel, Harold J., Avrin, Erna, Sorokin, Helen P., Sorokin, Sergei, Squier, C. A., Waterhouse, J. P., Steinbach, Günter, Steplewski, Zenon, Stitnimankarn, Tinrat, Stoward, Peter J., Straus, W., Stumpf, Walter E., Roth, Lloyd J., Sylvén, B., Kanamura, Shinsuke, Templeton, McCormick, Tewari, H. B., Tyagi, H. R., Thalmann, R., Glismann, L., Thomas, E., Tice, Lois W., Tixier-Vidal, A., Törö, I., Bacsy, E., Vadasz, Gy., Rappay, Gy., Tsou, K. C., Chang, Mildred Y., Matsukawa, S., Goodwin, Cleon, Lynm, Dwo, Seamond, Bette, Van Der Ploeg, M., Van Duijn, P., Coulter, J. R., Pascoe, E., Van Fleet, D. S., VanHouten, Wiecher H., Vecher, A. S., Masko, A. A., Predkel, K. I., Reshetnikov, V. N., Tchaika, M. T., Velican, C., Velican, Doina, Vendrely, C., Lageron, A., Tournier, P., Vialli, Maffo, Prenna, Giovanni, Vilter, Voldemar, Vittek, Josef, Vogt, Arnold, Vollrath, L., Von Mayersbach, Heinz, Vorbrodt, Andrzej, Wächtler, Klaus, Wakabayashi, Katsumi, Tamaoki, Bun-Ichi, Wald, Niel, Ranshaw, Russell, Weller, Roy O., Welsch, Ulrich, Werner, Gottfried, Williams, Vick, Morriss, Fran, Willighagen, R. G. J., Wilson, Barry W., Wohlrab, Frank, Wolf, Paul L., Horwitz, Jerome P., Freisler, Josef V., Von Der Muehll, Elisabeth, Vazquez, Janice, Wolman, Moshe, Yamada, Masaoki, Iwata, Sunao, Yamaguchi, Hisao, Yataganas, X., Gahrton, G., Young, Ian T., Zaccheo, D., Grossi, C. E., Genta, V., Riva, A., Zacks, S. I., Sheff, M. F., Zamfirescu-Gheorghiu, M., Serban, M., Vladescu, C., Chirulescu, Z., Marcus, N., Zelenin, A. V., Kirianova, E. A., Stepanova, N. G., Zeuthen, Erik, Zimmermann, Horst, Zugibe, Frederick T., Abrahamson, Dean E., Anderson, Norman G., Caspersson, Törbjorn, Cornell, Richard, Dougherty, William, Jirasek, J. E., Jonsson, Gösta, Leske, Regina, Moyer, Frank H., Schneider, Walter C., Siegel, Howard I., Sternberger, Ludwig, Osserman, Elliott F., Weinstock, A., and Rosenbaum, Robert M.

Published
1968
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40. Thoracic aortic rupture in horses

Author

Ploeg, M, Saey, V, van Loon, G, Delesalle, C, Veterinair Pathologisch Diagnostisch Cnt, LS Equine Internal Medicine, dPB CR, Veterinair Pathologisch Diagnostisch Cnt, LS Equine Internal Medicine, and dPB CR

Subjects
Aortic arch, medicine.medical_specialty, 040301 veterinary sciences, Fistula, Aortic Rupture, 030204 cardiovascular system & hematology, 0403 veterinary science, 03 medical and health sciences, Pseudoaneurysm, 0302 clinical medicine, Aneurysm, Internal medicine, medicine.artery, medicine, Animals, Genetic Predisposition to Disease, Interventricular septum, aortocardiac fistula, Horses, Aortic rupture, Aorta, business.industry, food and beverages, 04 agricultural and veterinary sciences, General Medicine, Anatomy, medicine.disease, horse, Friesian, aorta, medicine.anatomical_structure, Ventricle, aortopulmonary fistula, Cardiology, cardiovascular system, rupture, Horse Diseases, business
Abstract

The aorta can rupture at the aortic root or aortic arch. In most breeds, the aortic root is the likely site and rupture leads to aortocardiac fistula with communication between the aorta and the right atrium, right ventricle and/or the interventricular septum. There is a high prevalence of aortic rupture in young Friesian horses and rupture occurs at the aortic arch with pseudoaneurysm and potentially aortopulmonary fistulation. Echocardiographic and post-mortem techniques must be adapted to identify aortic arch rupture which is not generally identified with standard approaches. Given the narrow genetic base of the Friesian breed and the significant differences found in extracellular matrix composition and metabolism between Friesians and Warmbloods, genetic factors are likely to be contributing to the condition in the Friesian breed. This article is protected by copyright. All rights reserved.

Published
2016

41. Friesian horses as a possible model for human acquired aortopulmonary fistulation

Author

Saey, V, Vandecasteele, T, van Loon, G, Cornillie, P, Ploeg, M, Delesalle, C, Gröne, A, Gielen, I, Ducatelle, R, Chiers, K, Applied Veterinary Research, dPB CR, Applied Veterinary Research, and dPB CR

Subjects
Male, medicine.medical_specialty, 040301 veterinary sciences, aortic rupture, 030204 cardiovascular system & hematology, Pulmonary Artery, aortopumonary fistulation, General Biochemistry, Genetics and Molecular Biology, 0403 veterinary science, 03 medical and health sciences, Coronary circulation, Pseudoaneurysm, 0302 clinical medicine, Arterio-Arterial Fistula, medicine.artery, Internal medicine, Coronary Circulation, Medicine and Health Sciences, medicine, Technical Note, Thoracic aorta, Animals, Humans, Ultrasonics, Horses, Aortic rupture, Aortic dissection, Medicine(all), Aorta, business.industry, Biochemistry, Genetics and Molecular Biology(all), Biology and Life Sciences, pseudoaneurysm, 04 agricultural and veterinary sciences, General Medicine, medicine.disease, Surgery, Disease Models, Animal, medicine.anatomical_structure, friesian horses, Pulmonary artery, Cardiology, cardiovascular system, Aortopulmonary fistulation, Female, Complication, business
Abstract

Background Acquired aortopulmonary fistulation is a rare condition in humans. It usually results as a late complication of a true or pseudoaneurysm of the thoracic aorta. It is most commonly associated with trauma or surgery, less commonly with atherosclerosis, inflammation, hypertension or Marfan’s syndrome. Aortopulmonary fistulation is also seen as a rare complication of acute aortic dissection. On rare occasions, acquired aortopulmonary fistulation is reported in aged patients without any of the above mentioned triggering factors. Thus, these cases should be considered as idiopathic aortopulmonary fistulation. Clearly, the pathogenesis of this condition is not yet completely understood. Friesian horses are highly inbred and are affected by several genetic conditions. Rupture of the thoracic aorta has a relatively high prevalence in Friesian horses and is often characterized by the formation of a pseudoaneurysm with subsequent fistulation into the pulmonary artery. Affected animals may survive for several weeks to months. Findings Here we performed vascular casting in three affected Friesian horses. In all three cases, an aortic rupture at the caudoventral side of the aorta was connected with a rupture of the main pulmonary artery just proximal to its bifurcation. Conclusions Affected Friesians show a consistent location and configuration of the aortic rupture site, very similar to the human condition and therefore could act as a spontaneous model to study this disease. Electronic supplementary material The online version of this article (doi:10.1186/s13104-016-2201-5) contains supplementary material, which is available to authorized users.

Published
2016

42. Challenging Friesian horse diseases: aortic rupture and megaesophagus

Author

Ploeg, M., Veterinair Pathologisch Diagnostisch Cnt, dPB CR, Gröne, Andrea, van Weeren, René, Delesalle, Catherine, Chiers, K., and University Utrecht

Subjects
collagen, aorta, fluids and secretions, megaesophagus, animal diseases, morphology, cardiovascular system, food and beverages, elastin, biochemistry, Friesian horse, connective tissue
Abstract

Aortic rupture is quite rare in Warmblood horses and is best known as an acute and fatal rupture of the aortic root in older breeding stallions. It has now become clear that aortic rupture, which is diagnosed around an age of 4 years, is more frequent in the Friesian breed than in others. The high prevalence in Friesians may be due to increased genetic susceptibility Whereas Friesian horses with aortic rupture may develop acute forms, the majority of Friesians will display a subacute or chronic disease process. Friesians with a chronic form may show clinical signs, such as recidivating peripheral oedema, jugular pulsation or a strong bounding pulsation in the carotid artery, in the weeks to months prior to death. In Friesian horses the aortic rupture is encountered at the level of the aortic arch near the ligamentum arteriosum, which is more caudally than seen in Warmblood horses. Several cases showed presence of a longitudinal dissection of the aortic wall. A few Friesians with aortic rupture developed a circumferential cuff of blood around the aorta. All cases with chronic lesions in the aortic wall had an aorto-pulmonary fistulation in combination with a pseudoaneurysm. Factors that may interfere with the location of rupture in Friesians are genetic disorders, connective tissue disorders affecting the vessel wall integrity, geometrical abnormalities including wall thickness, lumen diameter and abnormal blood pressure. Histological features at the site of aortic rupture in Friesian horses are medial necrosis, disorganization and fragmentation of elastic laminae, aortic medial smooth muscle hypertrophy and accumulation of mucoid material. Biochemical analysis of the aortic wall in Friesian horses revealed increased MMP activity at the level of aortic rupture. Furthermore, the elastin cross-links desmosine and isodesmosine were increased, probably due to the remodeling and healing process at the site of rupture. Several biochemical differences between Friesians and Warmblood horses were demonstrated, including differences in the post-translational modifications of collagen in tendons and of GAG content in aorta and tendon tissue. Differences or changes in the ECM of the aorta of affected Friesians may have effects on the stiffness and strength of the aortic wall, and may also interfere with cell-matrix interactions and signaling cascades which are important for maintenance of the mechanical properties of the ECM. Clinically a high number of Friesians is suffering from megaesophagus (prevalence 2.2%), of which the majority is younger than 5 years. Morphological abnormalities were seen in the esophageal wall of young Friesians characterized by increased deposition of disorganized collagen and a decrease in elastin. These changes were present in the dilated but also in the non-dilated parts of the esophagus and were similar to those found in the aortic wall of Friesians with aortic rupture and aortopulmonary fistulation. Together, these findings are supportive of a systemic connective tissue disorder as underlying cause. Given the narrow genetic base of the Friesian breed and the significant differences found in extracellular matrix composition and metabolism between Friesians and warmbloods, a contribution of genetic factors to both Friesian disorders is likely.

Published
2015

43. Differences in extracellular matrix proteins between Friesian horses with aortic rupture, unaffected Friesians and Warmblood horses

Author

Ploeg, M, Gröne, A, van de Lest, C H A, Saey, V, Duchateau, L, Wolsein, P, Chiers, K, Ducatelle, R, van Weeren, P R, de Bruijn, M, Delesalle, C, Ploeg, M, Gröne, A, van de Lest, C H A, Saey, V, Duchateau, L, Wolsein, P, Chiers, K, Ducatelle, R, van Weeren, P R, de Bruijn, M, and Delesalle, C

Abstract

BACKGROUND: Aortic rupture is quite common in Friesian horses unlike in Warmblood horses and a hereditary trait is suspected in Friesians. The aortic connective tissue in affected Friesians shows histological changes such as medial necrosis, elastic fibre fragmentation, mucoid material accumulation and fibrosis with aberrant collagen morphology. However, ultrastructural examination of the collagen fibres of the mid-thoracic aorta was inconclusive when trying to further elucidate the pathogenesis of the disease.OBJECTIVES: To assess several extracellular matrix (ECM) components biochemically in order to explore a possible underlying breed-related systemic ECM defect in Friesians with aortic rupture.STUDY DESIGN: Cadaver study.METHODS: Tissues from affected Friesians (n = 18) were compared with unaffected Friesians (n = 10) and unaffected Friesians with Warmblood horses (n = 30). Samples were taken from the thoracic aorta at the level of the rupture site, from two locations caudal to the rupture and from the deep digital flexor tendon. Total collagen content, posttranslational modifications of collagen formation including lysine hydroxylation, and hydroxylysylpyridinoline (HP), lysylpyridinoline (LP) and pyrrole cross-links were analysed. Additionally, elastin cross-links, glycosaminoglycan (GAG) content, and matrix metalloproteinase (MMP) activity were assessed.RESULTS: Significantly increased MMP activity and increased LP and HP cross-linking, lysine hydroxylation, and elastin cross-linking were found at the site of rupture in affected Friesians. These changes may reflect processes involved in healing and aneurysm formation. Unaffected Friesians had less lysine hydroxylation and pyrrole cross-linking within the tendons compared to Warmblood horses. No differences in the matrix of the aorta were found between normal Warmbloods and Friesian horses.MAIN LIMITATIONS: Small sample size.CONCLUSIONS: The differences in collagen

Published
2017

44. Thoracic aortic rupture in horses

Author

Ploeg, M, Saey, V, van Loon, G, Delesalle, C, Ploeg, M, Saey, V, van Loon, G, and Delesalle, C

Abstract

The aorta can rupture at the aortic root or aortic arch. In most breeds, the aortic root is the likely site and rupture leads to aortocardiac fistula with communication between the aorta and the right atrium, right ventricle and/or the interventricular septum. There is a high prevalence of aortic rupture in young Friesian horses and rupture occurs at the aortic arch with pseudoaneurysm and potentially aortopulmonary fistulation. Echocardiographic and post-mortem techniques must be adapted to identify aortic arch rupture which is not generally identified with standard approaches. Given the narrow genetic base of the Friesian breed and the significant differences found in extracellular matrix composition and metabolism between Friesians and Warmbloods, genetic factors are likely to be contributing to the condition in the Friesian breed. This article is protected by copyright. All rights reserved.

Published
2017

45. Thoracic aortic rupture in horses

Author

Veterinair Pathologisch Diagnostisch Cnt, LS Equine Internal Medicine, dPB CR, Ploeg, M, Saey, V, van Loon, G, Delesalle, C, Veterinair Pathologisch Diagnostisch Cnt, LS Equine Internal Medicine, dPB CR, Ploeg, M, Saey, V, van Loon, G, and Delesalle, C

Published
2017

46. MisoREST: Surgical versus expectant management in women with an incomplete evacuation of the uterus after misoprostol treatment for miscarriage: A cohort study

Author

Lemmers, M., Verschoor, M.A., Oude Rengerink, K., Naaktgeboren, C., Bossuyt, P.M., Huirne, J.A., Janssen, I.A.W., Radder, C., Klinkert, E.R., Langenveld, J., Voet, L. Van der, Siemens, F.F., Bongers, M.Y., Hooff, M.H. van, Ploeg, M., Coppus, S.F.P.J., Ankum, W.M., Mol, B.W., Lemmers, M., Verschoor, M.A., Oude Rengerink, K., Naaktgeboren, C., Bossuyt, P.M., Huirne, J.A., Janssen, I.A.W., Radder, C., Klinkert, E.R., Langenveld, J., Voet, L. Van der, Siemens, F.F., Bongers, M.Y., Hooff, M.H. van, Ploeg, M., Coppus, S.F.P.J., Ankum, W.M., and Mol, B.W.

Abstract

Item does not contain fulltext, OBJECTIVE: To assess the effectiveness of curettage versus expectant management in women with an incomplete evacuation of the uterus after misoprostol treatment for first trimester miscarriage. STUDY DESIGN: We conducted a multicenter cohort study alongside a randomized clinical trial (RCT) between June 2012 until July 2014. 27 Dutch hospitals participated. Women with an incomplete evacuation after misoprostol treatment for first trimester miscarriage who declined to participate in the RCT, received treatment of their preference; curettage (n=65) or expectant management (n=132). A successful outcome was defined as an empty uterus on sonography at six weeks or uneventful clinical follow-up. We furthermore assessed complication rate and (re)intervention rate RESULTS: Of the 197 women who declined to participate in the RCT, 65 preferred curettage and 132 expectant management. A successful outcome was observed in 62/65 women (95%) in the surgical group versus 112/132 women (85%) in the expectant group (RR 1.1, 95% CI 1.03-1.2), with complication rates of 6.2% versus 2.3%, respectively (RR 2.7, 95% CI 0.6-12). CONCLUSION: In women with an incomplete evacuation of the uterus after misoprostol treatment, expectant management is an effective and safe option. This finding could restrain the use of curettage in women that have used misoprostol in the treatment of first trimester miscarriage.

Published
2017

47. Differences in extracellular matrix proteins between Friesian horses with aortic rupture, unaffected Friesians and Warmblood horses

Author

Veterinair Pathologisch Diagnostisch Cnt, LS Pathologie, LS Equine Muscoskeletal Biology, LS Veterinaire biochemie, dPB CR, dPB I&I, dB&C FR-RMSC FR, dES RMSC, dES AVR, Ploeg, M, Gröne, A, van de Lest, C H A, Saey, V, Duchateau, L, Wolsein, P, Chiers, K, Ducatelle, R, van Weeren, P R, de Bruijn, M, Delesalle, C, Veterinair Pathologisch Diagnostisch Cnt, LS Pathologie, LS Equine Muscoskeletal Biology, LS Veterinaire biochemie, dPB CR, dPB I&I, dB&C FR-RMSC FR, dES RMSC, dES AVR, Ploeg, M, Gröne, A, van de Lest, C H A, Saey, V, Duchateau, L, Wolsein, P, Chiers, K, Ducatelle, R, van Weeren, P R, de Bruijn, M, and Delesalle, C

Published
2017

48. Variation in hydrologic connectivity as a result of microtopography explained by discharge to catchment size relationship

Author

Oosterwoud, Marieke Rinske, van der Ploeg, M., van der Schaaf, S., van der Zee, S., Oosterwoud, Marieke Rinske, van der Ploeg, M., van der Schaaf, S., and van der Zee, S.

Abstract

In hydrological terms, raised bogs are often approximated by simple models as in the acrotelm–catotelm concept. However, raised bogs are often characterized by a pronounced surface topography, causing large changes in connectivity of contributing areas on the bog. In this study, daily regression of measured discharges versus catchment areas is used to quantify the impact of surface topography on catchment connectivity within a raised bog. The resulting coefficient of determination shows the strength of the relationship between the discharge and catchment area over time under different hydrological conditions. Monitoring of discharge, water table, transmissivity, and basic weather data on a raised bog (1.9 km2) in eastern central Estonia took place from May 2008 to June 2010. Contributing areas, calculated based on the outlet's discharge volume (VQ) divided by the net precipitation volume ( VPnet), of the outlet containing the central pool-ridge system varied between 1×10−3 and 0.7 km2, suggesting significant differences in connectivity between hydrological events. Correlation between discharge and theoretical catchment size was high (R2>0.75) when the water table was close to the surface (less than 5 cm below peat surface), and consequently, transmissivities were also high (up to 1,030m2d−1), which led to connectivity of local storage elements, such as pools and hollows. However, a water table below this threshold resulted in large parts of the catchment being disconnected. The importance of water table depths on catchment connectivity suggests the need to reconsider the hydrological concept of raised bogs; to incorporate these shallow flow components and better understand residence time and consequently transport of solutes, such as DOC, from patterned peatlands. &nbsp

Published
2017

50. Morphometric Properties of the Thoracic Aorta of Warmblood and Friesian Horses with and without Aortic Rupture

Author

Saey, V, Ploeg, M, Delesalle, C, van Loon, G, Gröne, A, Ducatelle, R, Duchateau, L, Chiers, K, Saey, V, Ploeg, M, Delesalle, C, van Loon, G, Gröne, A, Ducatelle, R, Duchateau, L, and Chiers, K

Abstract

Rupture of the aorta is much more common in Friesians compared with other breeds of horse. Rupture always occurs adjacent to the scar of the ligamentum arteriosum. Previous histological examination of ruptured aortic walls suggested the presence of an underlying connective tissue disorder. Therefore, the aim of the present study was to compare the structural characteristics of the tunica media of the mid-thoracic aorta, distant to the lesion, in warmblood and Friesian horses with and without thoracic aortic rupture. In unaffected Friesian horses, the thickness of the tunica media, as well as the percentage area comprised of collagen type I, were significantly higher compared with the warmblood horses, supporting the hypothesis of a primary collagen disorder in the Friesian horse breed. However, in the tunica media of the affected Friesian horses there was no significant wall thickening. Moreover, the percentage area comprised of elastin was significantly lower, while the percentage area comprised of smooth muscle was higher, compared with unaffected Friesian and warmblood horses. These lesions are suggestive of an additional mild elastin deficiency with compensatory smooth muscle cell hypertrophy in affected Friesians.

Published
2016

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