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262 results on '"Plenevaux, Alain"'

1. Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis

Author

Becker, Guillaume, Michel, Anne, Bahri, Mohamed Ali, Mairet-Coello, Georges, Lemaire, Christian, Deprez, Tania, Freyssin, Aline, Jacquin, Lucas, Hustadt, Fabian, De Wolf, Catherine, Caruso, Mélina, Frequin, Jean-Marie, Gillent, Eric, Bezard, Erwan, Garraux, Gaetan, Luxen, André, Citron, Martin, Downey, Patrick, and Plenevaux, Alain

Published
2021
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2. The Osteoblast Transcriptome in Developing Zebrafish Reveals Key Roles for Extracellular Matrix Proteins Col10a1a and Fbln1 in Skeletal Development and Homeostasis

Author

Raman, Ratish, primary, Antony, Mishal, additional, Nivelle, Renaud, additional, Lavergne, Arnaud, additional, Zappia, Jérémie, additional, Guerrero-Limón, Gustavo, additional, Caetano da Silva, Caroline, additional, Kumari, Priyanka, additional, Sojan, Jerry Maria, additional, Degueldre, Christian, additional, Bahri, Mohamed Ali, additional, Ostertag, Agnes, additional, Collet, Corinne, additional, Cohen-Solal, Martine, additional, Plenevaux, Alain, additional, Henrotin, Yves, additional, Renn, Jörg, additional, and Muller, Marc, additional

Published
2024
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6. Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma

Author

Jacques, Sophie, Arjomand, Arash, Perée, Hélène, Collins, Patrick, Mayer, Alice, Lavergne, Arnaud, Wéry, Marie, Mni, Myriam, Hego, Alexandre, Thuillier, Virginie, Becker, Guillaume, Bahri, Mohamed Ali, Plenevaux, Alain, Di Valentin, Emmanuel, Oury, Cécile, Moutschen, Michel, Delvenne, Philippe, Paquot, Nicolas, and Rahmouni, Souad

Published
2021
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12. A Zebrafish Mutant in the Extracellular Matrix Protein Gene efemp1 as a Model for Spinal Osteoarthritis.

Author

Raman, Ratish, Bahri, Mohamed Ali, Degueldre, Christian, Caetano da Silva, Caroline, Sanchez, Christelle, Ostertag, Agnes, Collet, Corinne, Cohen-Solal, Martine, Plenevaux, Alain, Henrotin, Yves, and Muller, Marc

Subjects
SPINE osteoarthritis, EXTRACELLULAR matrix proteins, JOINT pain, BRACHYDANIO, KNEE joint, HOMEOSTASIS
Abstract

Simple Summary: Osteoarthritis is a debilitating and painful joint disease affecting mainly aging animals and people. Previous results indicated that Efemp1, a protein present in the extracellular matrix that surrounds each cell, is increased in the blood, urine, and bone of osteoarthritic patients. We used the zebrafish as a model system to investigate the role of the Efemp1 protein in skeletal development and homeostasis. We showed that the efemp1 gene is expressed in the brain, the pharyngeal cartilage, and the developing notochord which will later form the vertebral column. We generated a mutant in this gene, devoid of a functional Efemp1 protein, to show that this mutant presents transient deformities in its head cartilage at early stages. More importantly, adult mutants expressed a phenotype characterized by a smaller distance between vertebrae and ruffled edges (bone spurs) at the vertebral ends. This defect is reminiscent of that observed in spinal osteoarthritis; we therefore propose the efemp1−/− mutant line as the first zebrafish model to study this condition. Osteoarthritis is a degenerative articular disease affecting mainly aging animals and people. The extracellular matrix protein Efemp1 was previously shown to have higher turn-over and increased secretion in the blood serum, urine, and subchondral bone of knee joints in osteoarthritic patients. Here, we use the zebrafish as a model system to investigate the function of Efemp1 in vertebrate skeletal development and homeostasis. Using in situ hybridization, we show that the efemp1 gene is expressed in the brain, the pharyngeal arches, and in the chordoblasts surrounding the notochord at 48 hours post-fertilization. We generated an efemp1 mutant line, using the CRISPR/Cas9 method, that produces a severely truncated Efemp1 protein. These mutant larvae presented a medially narrower chondrocranium at 5 days, which normalized later at day 10. At age 1.5 years, µCT analysis revealed an increased tissue mineral density and thickness of the vertebral bodies, as well as a decreased distance between individual vertebrae and ruffled borders of the vertebral centra. This novel defect, which has, to our knowledge, never been described before, suggests that the efemp1 mutant represents the first zebrafish model for spinal osteoarthritis. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model

Author

Nchimi, Alain, Courtois, Audrey, El Hachemi, Mounia, Touat, Ziad, Drion, Pierre, Withofs, Nadia, Warnock, Geoff, Bahri, Mohamed-Ali, Dogné, Jean-Michel, Cheramy-Bien, Jean-Paul, Schoysman, Laurent, Joskin, Julien, Michel, Jean-Baptiste, Defraigne, Jean-Olivier, Plenevaux, Alain, and Sakalihasan, Natzi

Published
2016
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25. PET‐[18F]UCB‐H for assessing synaptic density in FTD

Author

Salmon, Eric, primary, Bahri, Mohamed Ali, additional, Plenevaux, Alain, additional, Becker, Guillaume, additional, Seret, Alain, additional, Giacomelli, Fabrice, additional, Delhaye, Emma, additional, Degueldre, Christian, additional, Balteau, Evelyne, additional, Luxen, André, additional, and Bastin, Christine, additional

Published
2020
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27. The Pharmacokinetics of [18F]UCB-H Revisited in The Healthy Non-Human Primate Brain

Author

Goutal, Sébastien, primary, Guillermier, Martine, additional, Becker, Guillaume, additional, Gaudin, Mylène, additional, Bramoullé, Yann, additional, Luxen, André, additional, Lemaire, Christian, additional, Plenevaux, Alain, additional, Salmon, Eric, additional, Hantraye, Philippe, additional, Barret, Olivier, additional, and Camp, Nadja Van, additional

Published
2020
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33. In vivo imaging of synaptic loss in Alzheimer’s disease with [18F]UCB-H positron emission tomography

Author

Bastin, Christine, primary, Bahri, Mohamed Ali, additional, Meyer, François, additional, Manard, Marine, additional, Delhaye, Emma, additional, Plenevaux, Alain, additional, Becker, Guillaume, additional, Seret, Alain, additional, Mella, Christine, additional, Giacomelli, Fabrice, additional, Degueldre, Christian, additional, Balteau, Evelyne, additional, Luxen, André, additional, and Salmon, Eric, additional

Published
2019
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36. Evaluating the In Vivo Specificity of [18F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET

Author

Serrano, Maria Elisa, primary, Becker, Guillaume, additional, Bahri, Mohamed Ali, additional, Seret, Alain, additional, Mestdagh, Nathalie, additional, Mercier, Joël, additional, Mievis, Frédéric, additional, Giacomelli, Fabrice, additional, Lemaire, Christian, additional, Salmon, Eric, additional, Luxen, André, additional, and Plenevaux, Alain, additional

Published
2019
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40. Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.

Author

Serrano, Maria Elisa, Bahri, Mohamed Ali, Becker, Guillaume, Seret, Alain, Germonpré, Charlotte, Lemaire, Christian, Giacomelli, Fabrice, Mievis, Frédéric, Luxen, André, Salmon, Eric, Rogister, Bernard, Raedt, Robrecht, and Plenevaux, Alain

Subjects
RADIOACTIVE tracers, TEMPORAL lobe epilepsy, KAINIC acid, SPRAGUE Dawley rats, POSITRON emission tomography, SYNAPTIC vesicles
Abstract

Purpose: The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model.Procedures: Twenty Sprague Dawley male rats were administered with multiple systemic doses of saline (control group, n = 5) or kainic acid (5 mg/kg/injection, epileptic group, n = 15). Both groups were scanned at the four phases of TLE (early, latent, transition, and chronic phase) with the [18F]UCB-H PET radiotracer and T2-structural magnetic resonance imaging. At the end of the scans (3 months post-status epilepticus), rats were monitored for 7 days with electroencephalography for the detection of spontaneous electrographic seizures. Finally, the immunofluorescence staining for SV2A expression was performed.Results: Control rats presented a significant increase in [18F]UCB-H binding at the last two scans, compared with the first ones (p < 0.001). This increase existed but was lower in epileptic animals, producing significant group differences in all the phases of the disease (p < 0.028). Furthermore, the quantification of the SV2A expression in vivo with the [18F]UCB-H radiotracer or ex vivo with immunofluorescence led to equivalent results, with a positive correlation between both.Conclusions: Even if further studies in humans are required, the ability to detect a progressive decrease in SV2A expression during the development of temporal lobe epilepsy supports the use of [18F]UCB-H as a useful tool to differentiate, in vivo, between healthy and epileptic animals along with the development of the epileptic disease. [ABSTRACT FROM AUTHOR]

Published
2020
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43. The Severe Deficiency of the Somatotrope GH-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor 1 Axis of Ghrh−/− Mice Is Associated With an Important Splenic Atrophy and Relative B Lymphopenia

Author

Bodart, Gwennaelle, primary, Farhat, Khalil, additional, Renard-Charlet, Chantal, additional, Becker, Guillaume, additional, Plenevaux, Alain, additional, Salvatori, Roberto, additional, Geenen, Vincent, additional, and Martens, Henri, additional

Published
2018
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44. Nanofitin as a New Molecular-Imaging Agent for the Diagnosis of Epidermal Growth Factor Receptor Over-Expressing Tumors

Author

Goux, Marine, Doumont, Gilles, Plenevaux, Alain, Cinier, Mathieu, Luxen, André, Becker, Guillaume, Gorré, Harmony, Dammicco, Sylvestre, Desselle, Ariane, Egrise, Dominique, Leroi, Natacha, Lallemand, Françoise, Bahri, Mohamed Ali, Goux, Marine, Doumont, Gilles, Plenevaux, Alain, Cinier, Mathieu, Luxen, André, Becker, Guillaume, Gorré, Harmony, Dammicco, Sylvestre, Desselle, Ariane, Egrise, Dominique, Leroi, Natacha, Lallemand, Françoise, and Bahri, Mohamed Ali

Abstract

Epidermal growth-factor receptor (EGFR) is involved in cell growth and proliferation and is over-expressed in malignant tissues. Although anti-EGFR-based immunotherapy became a standard of care for patients with EGFR-positive tumors, this strategy of addressing cancer tumors by targeting EGFR with monoclonal antibodies is less-developed for patient diagnostic and monitoring. Indeed, antibodies exhibit a slow blood clearance, which is detrimental for positron emission tomography (PET) imaging. New molecular probes are proposed to overcome such limitations for patient monitoring, making use of low-molecular-weight protein scaffolds as alternatives to antibodies, such as Nanofitins with better pharmacokinetic profiles. Anti-EGFR Nanofitin B10 was reformatted by genetic engineering to exhibit a unique cysteine moiety at its C-terminus, which allows the development of a fast and site-specific radiolabeling procedure with 18F-4-fluorobenzamido-N-ethylamino-maleimide (18F-FBEM). The in vivo tumor targeting and imaging profile of the anti-EGFR Cys-B10 Nanofitin was investigated in a double-tumor xenograft model by static small-animal PET at 2 h after tail-vein injection of the radiolabeled Nanofitin 18F-FBEM-Cys-B10. The image showed that the EGFR-positive tumor (A431) is clearly delineated in comparison to the EGFR-negative tumor (H520) with a significant tumor-to-background contrast. 18F-FBEM-Cys-B10 demonstrated a significantly higher retention in A431 tumors than in H520 tumors at 2.5 h post-injection with a A431-to-H520 uptake ratio of 2.53 ± 0.18 and a tumor-to-blood ratio of 4.55 ± 0.63. This study provides the first report of Nanofitin scaffold used as a targeted PET radiotracer for in vivo imaging of EGFR-positive tumor, with the anti-EGFR B10 Nanofitin used as proof-of-concept. The fast generation of specific Nanofitins via a fully in vitro selection process, together with the excellent imaging features of the Nanofitin scaffold, could facilitate the development o, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017

45. 30th Franco-Belgian conference of pharmacochemistry

Author

Bouckaert, Charlotte, Goffin, Eric, Dilly, Sebastien, Hanson, Julien, Pochet, Lionel, Kastrup, Jette Sandholm, Francotte, Pierre, Pirotte, Bernard, Michiels, Carine, Champire, Anthony, Ple, Karen, Robin, Laurent, Suzenet, Franck, Bouyssou, Pascal, Burgy, Guillaume, Limanton, Emmanuelle, Guiheneuf, Solene, Carreaux, Francois, Tahtouh, Tania, Durieu, Emilie, Meijer, Laurent, Pipelier, Muriel, Plenevaux, Alain, Place, Mattieu, Copin, Chloe, Ambeu, Christelle, Coulibaly, Wacothon Karime, Mamyrbekova-Berkro, Janat, Benie, Anoubile, Corlu, Anne, Bach, Stephane, Dago, Camille Deliko, Paquin, Ludovic, Mamyrbekova-Bekro, Janat Akhanovna, Bekro, Yves-Alain, Ruchaud, Sandrine, Le Guevel, Remy, Brigaudeau, Christophe, Mignen, Olivier, Bazureau, Jean-Pierre, Gally, Jose-Manuel, Heinrich, Jean-Thomas, Obled, Alan, Aci-Seche, Samia, Bonnet, Pascal, Gibault, Floriane, Corvaisier, Matthieu, Bailly, Fabrice, Huet, Guillemette, Cotelle, Philippe, Duroux, Romain, Renault, Nicolas, Agouridas, Laurence, Lopes, Luisa, Melnyk, Patricia, Yous, Said, Piguel, Sandrine, Stutzmann, Aurelien, Schnetterle, Marine, Caclard, Arnaud, Biot, Fabrice, Valade, Eric, Bolla, Jean-Michel, Pages, Jean-Marie, Boyer, Gerard, Alibert, Sandrine, Neulat-Ripoll, Fabienne, Elie, Jonathan, Bidault, Rudy, Arlicot, Nicolas, GUILLOTEAU, Denis, Vercouille, Johnny, D'Attoma, Joseph, Brun, Pierre-Louis, Robin, Yves, Bostyn, Stephane, Ejjoummany, Abdelaziz, Buron, Frederic, El Hakmaoui, Ahmed, Routier, Sylvain, Guillaumet, Gerald, Akssira, Mohamed, Marx, Sebastien, Dal Maso, Thomas, Michiels, Cerine, Wouters, Johan, Prevost, Julien R. C., Van Ham, Nicolas J. P., Kozlova, Arina, Frederick, Raphael, Drapier, Thomas, Geubelle, Pierre, Department of Medicinal Chemistry, Natural and Synthetic Drugs Research Centre, Université de Liège, Université de Namur [Namur] (UNamur), Institut de Chimie Organique et Analytique (ICOA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ManRos Therapeutics, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Phophorylation de protéines et Pathologies Humaines (P3H), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Bioorganique et des Substances Naturelles (LCBOSN), Université Abobo-Adjamé, Université Péléforo Gon Coulibaly, UFR des Sciences Biologiques, Korhogo BP 1328, Côte d’Ivoire, Plate-forme ImPACcell (ImPACcell), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Nangui Abrogoua (UNA), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ), Laboratoire d'Innovation Thérapeutique (LIT), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Instituto de Medicina Molecular (iMM), Faculdade de Medicina [Lisboa], Universidade de Lisboa = University of Lisbon (ULISBOA)-Universidade de Lisboa = University of Lisbon (ULISBOA), Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Transporteurs membranaires, chimioresistance et drug-design (TMCD2), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Membranes et cibles thérapeutiques (MCT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Calculateurs Parallèles (CALCPAR), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-INRIA Rennes, Institut National de Recherche en Informatique et en Automatique (Inria), Institut de Combustion, Aérothermique, Réactivité et Environnement (ICARE), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences de l'Ingénierie et des Systèmes (INSIS - CNRS), Laboratoire de Chimie Physique & de Chimie Bioorganique, URAC 22 (LCPCB), Faculte des sciences et Techniques Mohammedia [Casablanca] (FSTM), Université Hassan II [Casablanca] (UH2MC)-Université Hassan II [Casablanca] (UH2MC), Laboratoire de Chimie, Bioorganique et analytique, Université Hassan II [Casablanca] (UH2MC), Université Catholique de Louvain = Catholic University of Louvain (UCL), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université Nangui Abrogoua, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Universidade de Lisboa (ULISBOA)-Universidade de Lisboa (ULISBOA), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Institut de Recherche Biomédicale des Armées (IRBA), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées (IRBA), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-INRIA Rennes, Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences de l'Ingénierie et des Systèmes (INSIS), Université de Namur [Namur], Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Rennes-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc - U1172 Inserm), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université Lille 2 - Faculté de Médecine, Centre de recherche Jean-Pierre Aubert-Neurosciences et Cancer, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Lille Inflammation Research International Center (LIRIC), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Imagerie et cerveau, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Université Catholique de Louvain (UCL), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées (IRBA)-Aix Marseille Université (AMU), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
pharmacochemistry, target discovery, organic and medicinal chemistry, [CHIM]Chemical Sciences, pharmacology, chemoinformatics, medical imagery, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; The “Journées Franco-Belges de Pharmacochimie” is a recognized annual meeting in organic and medicinal chemistry known for the quality of scientific exchange and conviviality. Young researchers were encouraged to present their work and share ideas with senior scientists. Abstracts of plenary lectures, oral communications, and posters presented during the meeting are collected in this report.

Published
2016

46. Nanofitin as a New Molecular-Imaging Agent for the Diagnosis of Epidermal Growth Factor Receptor Over-Expressing Tumors

Author

Goux, Marine, primary, Becker, Guillaume, additional, Gorré, Harmony, additional, Dammicco, Sylvestre, additional, Desselle, Ariane, additional, Egrise, Dominique, additional, Leroi, Natacha, additional, Lallemand, François, additional, Bahri, Mohamed Ali, additional, Doumont, Gilles, additional, Plenevaux, Alain, additional, Cinier, Mathieu, additional, and Luxen, André, additional

Published
2017
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47. Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18 F]UCB-H

Author

Bahri, Mohamed Ali, primary, Plenevaux, Alain, additional, Aerts, Joël, additional, Bastin, Christine, additional, Becker, Guillaume, additional, Mercier, Joël, additional, Valade, Anne, additional, Buchanan, Tim, additional, Mestdagh, Nathalie, additional, Ledoux, Didier, additional, Seret, Alain, additional, Luxen, André, additional, and Salmon, Eric, additional

Published
2017
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