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1. Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy

Author

Farina, C., Vailati, F., Gesu, G., Vismara, C., Arghittu, M., Colombo, R., Torresani, E., Rossi, L., Conaldi, P.G., Gona, F., Cambieri, P., Marone, P., Venditti, C., Fernandez, A. Garcia, Mancini, C., Cusi, M., De Angelis, L. Henrici, Fossati, L., Finarelli, A.C., De Cillia, C., Sangiorgi, G., Pinna, A.D., Stella, F., Viale, P., Colledan, M., Platto, M., Bonizzoli, M., Peris, A., Torelli, R., Vesconi, S., Cibelli, E., De Carlis, L., De Gasperi, A., Ravini, M., Carrinola, R., Coluccio, E., Dondossola, D., Rossi, G., Santambrogio, L., Tosi, D., Feltrin, G., Rago, C., Cillo, U., Da Riva, A., Rea, F., Sparacino, V., Bertani, A., Canzonieri, M., Gridelli, B., Mularoni, A., Spada, M., Carrara, E., D’Armini, A. Maria, Paladini, P., Adorno, D., Valeri, M., Caprio, M., Di Ciaccio, P., Puoti, F., Berloco, P., D’Auria, B., Maldarelli, F., Paglialunga, G., Pugliese, F., Rossi, M., Venuta, F., Amoroso, A., Giacometti, R., Rinaldi, M., Salizzoni, M., Errico, G., Gagliotti, C., Monaco, M., Masiero, L., Gaibani, P., Ambretti, S., Landini, M.P., D’Arezzo, S., Di Caro, A., Parisi, S.G., Palù, G., Vespasiano, F., Morsillo, F., Moro, M.L., Procaccio, F., Ricci, A., Grossi, P.A., Pantosti, A., and Nanni Costa, A.

Published
2019
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4. Infections in liver and lung transplant recipients. A national prospective cohort

Author

Gagliotti, Carlo, Morsillo, Filomena, Moro, Maria Luisa, Masiero, Lucia, Procaccio, Francesco, Vespasiano, Francesca, Pantosti, Annalisa, Monaco, Monica, Errico, Giulia, Ricci, Andrea, Grossi, Paolo, Nanni Costa, Alessandro, Adorno, D., Ambretti, S., Amoroso, A., Arghittu, M., Berloco, P., Bertani, A., Bonizzoli, M., Cambieri, P., Canzonieri, M., Caprio, M., Carrara, E., Carrinola, R., Cibelli, E., Cillo, U., Colledan, M., Colombo, R., Coluccio, E., Conaldi, P. G., Cusi, M., D’Armini, A. M., da Riva, A., D’Auria, B., de Carlis, L., de Cillia, C., de Gasperi, A., Di Caro, A., Di Ciaccio, P., Dondossola, D., Farina, C., Feltrin, G., Finarelli, A. C., Fossati, L., Gaibani, P., Garcia Fernandez, A., Gesu, G., Giacometti, R., Gona, F., Gridelli, B., Henrici de Angelis, L., Landini, M. P., Maldarelli, F., Mancini, C., Marone, P., Mularoni, A., Paglialunga, G., Paladini, P., Palù, G., Parisi, S., Peris, A., Pinna, A. D., Platto, M., Pugliese, F., Puoti, F., Rago, C., Ravini, M., Rea, F., Rinaldi, M., Rossi, G., Rossi, L., Rossi, M., Salizzoni, M., Sangiorgi, G., Santambrogio, L., Spada, M., Sparacino, V., Stella, F., Torelli, R., Torresani, E., Tosi, D., Vailati, F., Valeri, M., Venuta, F., Vesconi, S., Viale, P., Vismara, C., Gagliotti, C, Morsillo, F, Moro, M, Masiero, L, Procaccio, F, Vespasiano, F, Pantosti, A, Monaco, M, Errico, G, Ricci, A, Grossi, P, Nanni Costa, A, Adorno, D, Ambretti, S, Amoroso, A, Arghittu, M, Berloco, P, Bertani, A, Bonizzoli, M, Cambieri, P, Canzonieri, M, Caprio, M, Carrara, E, Carrinola, R, Cibelli, E, Cillo, U, Colledan, M, Colombo, R, Coluccio, E, Conaldi, P, Cusi, M, D’Armini, A, da Riva, A, D’Auria, B, de Carlis, L, de Cillia, C, de Gasperi, A, Di Caro, A, Di Ciaccio, P, Dondossola, D, Farina, C, Feltrin, G, Finarelli, A, Fossati, L, Gaibani, P, Garcia Fernandez, A, Gesu, G, Giacometti, R, Gona, F, Gridelli, B, Henrici de Angelis, L, Landini, M, Maldarelli, F, Mancini, C, Marone, P, Mularoni, A, Paglialunga, G, Paladini, P, Palù, G, Parisi, S, Peris, A, Pinna, A, Platto, M, Pugliese, F, Puoti, F, Rago, C, Ravini, M, Rea, F, Rinaldi, M, Rossi, G, Rossi, L, Rossi, M, Salizzoni, M, Sangiorgi, G, Santambrogio, L, Spada, M, Sparacino, V, Stella, F, Torelli, R, Torresani, E, Tosi, D, Vailati, F, Valeri, M, Venuta, F, Vesconi, S, Viale, P, Vismara, C, Gagliotti, Carlo, Morsillo, Filomena, Moro, Maria Luisa, Masiero, Lucia, Procaccio, Francesco, Vespasiano, Francesca, Pantosti, Annalisa, Monaco, Monica, Errico, Giulia, Ricci, Andrea, Grossi, Paolo, Costa, Alessandro Nanni, Adorno, Domenico, Ambretti, Simone, Amoroso, Antonio, Arghittu, Milena, Berloco, Pasquale, Bertani, Alessandro, Bonizzoli, Manuela, Cambieri, Patrizia, Canzonieri, Marco, Caprio, Mario, Carrara, Elena, Carrinola, Rosaria, Cibelli, Eva, Cillo, Umberto, Colledan, Michele, Colombo, Rosaria, Coluccio, Elena, Conaldi, Pier Giulio, Cusi, Mariagrazia, D’Armini, Andrea Maria, Da Riva, Adelaide, D'Auria, Bianca, De Carlis, Luciano, De Cillia, Carlo, De Gasperi, Andrea, Di Caro, Antonino, Di Ciaccio, Paola, Dondossola, Daniele, Farina, Claudio, Feltrin, Giuseppe, Finarelli, Alba Carola, Fossati, Lucina, Gaibani, Paolo, Fernandez, Aurora Garcia, Gesu, Giovanni, Giacometti, Raffaella, Gona, Floriana, Gridelli, Bruno, De Angelis, Lucia Henrici, Landini, Maria Paola, Maldarelli, Federica, Mancini, Carlo, Marone, Piero, Mularoni, Alessandra, Paglialunga, Giulia, Paladini, Piero, Palù, Giorgio, Parisi, Saverio, Peris, Adriano, Pinna, Antonio Daniele, Platto, Marco, Pugliese, Francesco, Puoti, Francesca, Rago, Claudio, Ravini, Mario, Rea, Federico, Rinaldi, Mauro, Rossi, Giorgio, Rossi, Lucia, Rossi, Massimo, Salizzoni, Mauro, Sangiorgi, Gabriela, Santambrogio, Luigi, Spada, Marco, Sparacino, Vito, Stella, Franco, Torelli, Rosanna, Torresani, Erminio, Tosi, Davide, Vailati, Francesca, Valeri, Maurizio, Venuta, Federico, Vesconi, Sergio, Viale, Pierluigi, and Vismara, Chiara

Subjects
Microbiology (medical), Infectious Diseases, Male, 0301 basic medicine, medicine.medical_treatment, Drug Resistance, Transplant Recipient, 030230 surgery, Liver transplantation, Postoperative Complications, 0302 clinical medicine, Drug Resistance, Multiple, Bacterial, Medicine, Cumulative incidence, Prospective Studies, Prospective cohort study, Incidence, Incidence (epidemiology), Mortality rate, Bacterial, Bacterial Infections, General Medicine, Middle Aged, lung transplant, Anti-Bacterial Agents, infectious, Italy, Female, Multiple, Adult, Bacteria, Humans, Transplant Recipients, Liver Transplantation, Lung Transplantation, Human, medicine.medical_specialty, 030106 microbiology, Bacterial Infection, Infectious Diseases, transplantation, 03 medical and health sciences, Internal medicine, Anti-Bacterial Agent, Lung transplantation, business.industry, lung transplant, liver transplant, infectious, Transplantation, Prospective Studie, liver transplant, Etiology, Postoperative Complication, business, transplantation
Abstract

Infections are a major complication of solid organ transplants (SOTs). This study aimed to describe recipients’ characteristics, and the frequency and etiology of infections and transplant outcome in liver and lung SOTs, and to investigate exposures associated to infection and death in liver transplant recipients. The study population included recipients of SOTs performed in Italy during a 1-year period in ten Italian lung transplant units and eight liver transplant units. Data on comorbidities, infections, retransplantation, and death were prospectively collected using a web-based system, with a 6-month follow-up. The cumulative incidence of infection was 31.7% and 47.8% in liver and lung transplants, respectively, with most infections occurring within the first month after transplantation. Gram-negatives, which were primarily multidrug-resistant, were the most frequent cause of infection. Death rates were 0.42 per 1000 recipient-days in liver transplants and 1.41 per 1000 recipient-days in lung transplants. Infection after SOT in adult liver recipients is associated to an increased risk of death (OR = 13.25; p-value < 0.001). Given the frequency of infection caused by multidrug-resistant microorganisms in SOT recipients in Italy and the heavy impact of infections on the transplant outcome, the reinforcement of surveillance and control activities to prevent the transmission of multidrug-resistant microorganisms in SOT recipients represents a priority. The implementation of the study protocol in liver and lung transplant units and the sharing of results have increased the awareness about the threat due to antimicrobial resistance in the country.

Published
2018

5. Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy

Author

Errico, G., primary, Gagliotti, C., additional, Monaco, M., additional, Masiero, L., additional, Gaibani, P., additional, Ambretti, S., additional, Landini, M.P., additional, D’Arezzo, S., additional, Di Caro, A., additional, Parisi, S.G., additional, Palù, G., additional, Vespasiano, F., additional, Morsillo, F., additional, Moro, M.L., additional, Procaccio, F., additional, Ricci, A., additional, Grossi, P.A., additional, Pantosti, A., additional, Nanni Costa, A., additional, Farina, C., additional, Vailati, F., additional, Gesu, G., additional, Vismara, C., additional, Arghittu, M., additional, Colombo, R., additional, Torresani, E., additional, Rossi, L., additional, Conaldi, P.G., additional, Gona, F., additional, Cambieri, P., additional, Marone, P., additional, Venditti, C., additional, Fernandez, A. Garcia, additional, Mancini, C., additional, Cusi, M., additional, De Angelis, L. Henrici, additional, Fossati, L., additional, Finarelli, A.C., additional, De Cillia, C., additional, Sangiorgi, G., additional, Pinna, A.D., additional, Stella, F., additional, Viale, P., additional, Colledan, M., additional, Platto, M., additional, Bonizzoli, M., additional, Peris, A., additional, Torelli, R., additional, Vesconi, S., additional, Cibelli, E., additional, De Carlis, L., additional, De Gasperi, A., additional, Ravini, M., additional, Carrinola, R., additional, Coluccio, E., additional, Dondossola, D., additional, Rossi, G., additional, Santambrogio, L., additional, Tosi, D., additional, Feltrin, G., additional, Rago, C., additional, Cillo, U., additional, Da Riva, A., additional, Rea, F., additional, Sparacino, V., additional, Bertani, A., additional, Canzonieri, M., additional, Gridelli, B., additional, Mularoni, A., additional, Spada, M., additional, Carrara, E., additional, D’Armini, A. Maria, additional, Paladini, P., additional, Adorno, D., additional, Valeri, M., additional, Caprio, M., additional, Di Ciaccio, P., additional, Puoti, F., additional, Berloco, P., additional, D’Auria, B., additional, Maldarelli, F., additional, Paglialunga, G., additional, Pugliese, F., additional, Rossi, M., additional, Venuta, F., additional, Amoroso, A., additional, Giacometti, R., additional, Rinaldi, M., additional, and Salizzoni, M., additional

Published
2019
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6. Infections in liver and lung transplant recipients: a national prospective cohort

Author

Gagliotti, C, Morsillo, F, Moro, M, Masiero, L, Procaccio, F, Vespasiano, F, Pantosti, A, Monaco, M, Errico, G, Ricci, A, Grossi, P, Nanni Costa, A, Adorno, D, Ambretti, S, Amoroso, A, Arghittu, M, Berloco, P, Bertani, A, Bonizzoli, M, Cambieri, P, Canzonieri, M, Caprio, M, Carrara, E, Carrinola, R, Cibelli, E, Cillo, U, Colledan, M, Colombo, R, Coluccio, E, Conaldi, P, Cusi, M, D’Armini, A, da Riva, A, D’Auria, B, de Carlis, L, de Cillia, C, de Gasperi, A, Di Caro, A, Di Ciaccio, P, Dondossola, D, Farina, C, Feltrin, G, Finarelli, A, Fossati, L, Gaibani, P, Garcia Fernandez, A, Gesu, G, Giacometti, R, Gona, F, Gridelli, B, Henrici de Angelis, L, Landini, M, Maldarelli, F, Mancini, C, Marone, P, Mularoni, A, Paglialunga, G, Paladini, P, Palù, G, Parisi, S, Peris, A, Pinna, A, Platto, M, Pugliese, F, Puoti, F, Rago, C, Ravini, M, Rea, F, Rinaldi, M, Rossi, G, Rossi, L, Rossi, M, Salizzoni, M, Sangiorgi, G, Santambrogio, L, Spada, M, Sparacino, V, Stella, F, Torelli, R, Torresani, E, Tosi, D, Vailati, F, Valeri, M, Venuta, F, Vesconi, S, Viale, P, Vismara, C, Gagliotti, C, Morsillo, F, Moro, M, Masiero, L, Procaccio, F, Vespasiano, F, Pantosti, A, Monaco, M, Errico, G, Ricci, A, Grossi, P, Nanni Costa, A, Adorno, D, Ambretti, S, Amoroso, A, Arghittu, M, Berloco, P, Bertani, A, Bonizzoli, M, Cambieri, P, Canzonieri, M, Caprio, M, Carrara, E, Carrinola, R, Cibelli, E, Cillo, U, Colledan, M, Colombo, R, Coluccio, E, Conaldi, P, Cusi, M, D’Armini, A, da Riva, A, D’Auria, B, de Carlis, L, de Cillia, C, de Gasperi, A, Di Caro, A, Di Ciaccio, P, Dondossola, D, Farina, C, Feltrin, G, Finarelli, A, Fossati, L, Gaibani, P, Garcia Fernandez, A, Gesu, G, Giacometti, R, Gona, F, Gridelli, B, Henrici de Angelis, L, Landini, M, Maldarelli, F, Mancini, C, Marone, P, Mularoni, A, Paglialunga, G, Paladini, P, Palù, G, Parisi, S, Peris, A, Pinna, A, Platto, M, Pugliese, F, Puoti, F, Rago, C, Ravini, M, Rea, F, Rinaldi, M, Rossi, G, Rossi, L, Rossi, M, Salizzoni, M, Sangiorgi, G, Santambrogio, L, Spada, M, Sparacino, V, Stella, F, Torelli, R, Torresani, E, Tosi, D, Vailati, F, Valeri, M, Venuta, F, Vesconi, S, Viale, P, and Vismara, C

Abstract

Infections are a major complication of solid organ transplants (SOTs). This study aimed to describe recipients’ characteristics, and the frequency and etiology of infections and transplant outcome in liver and lung SOTs, and to investigate exposures associated to infection and death in liver transplant recipients. The study population included recipients of SOTs performed in Italy during a 1-year period in ten Italian lung transplant units and eight liver transplant units. Data on comorbidities, infections, retransplantation, and death were prospectively collected using a web-based system, with a 6-month follow-up. The cumulative incidence of infection was 31.7% and 47.8% in liver and lung transplants, respectively, with most infections occurring within the first month after transplantation. Gram-negatives, which were primarily multidrug-resistant, were the most frequent cause of infection. Death rates were 0.42 per 1000 recipient-days in liver transplants and 1.41 per 1000 recipient-days in lung transplants. Infection after SOT in adult liver recipients is associated to an increased risk of death (OR = 13.25; p-value < 0.001). Given the frequency of infection caused by multidrug-resistant microorganisms in SOT recipients in Italy and the heavy impact of infections on the transplant outcome, the reinforcement of surveillance and control activities to prevent the transmission of multidrug-resistant microorganisms in SOT recipients represents a priority. The implementation of the study protocol in liver and lung transplant units and the sharing of results have increased the awareness about the threat due to antimicrobial resistance in the country

Published
2018

7. The hemostatic status of pediatric recipients of adult liver grafts suggests that plasma levels of hemostatic proteins are not regulated by the liver

Author

Lisman, T, Platto, M, Meijers, J, Haagsma, E, Colledan, M, Porte, R, Lisman T, Platto M, Meijers JCM, Haagsma EB, Colledan M, Porte RJ, Lisman, T, Platto, M, Meijers, J, Haagsma, E, Colledan, M, Porte, R, Lisman T, Platto M, Meijers JCM, Haagsma EB, Colledan M, and Porte RJ

Abstract

Plasma levels of coagulation factors differ profoundly between adults and children, but are remarkably stable throughout adulthood. It is unknown which factors determine plasma levels of coagulation factors in a given individual. We hypothesized that the liver, which synthesizes coagulation factors, also controls plasma levels. We measured a panel of coagulation factors in samples taken from either adults or young children who underwent a liver transplantation with adult donor livers. Samples were taken 1-3 months after transplantation, when the patients were clinically stable with adequate graft function. After liver transplantation, the hemostatic profile of the pediatric group was remarkably different from that of the adult group, and resembled the hemostatic profile of normal children. Thus, children transplanted with an adult liver graft maintain a pediatric hemostatic pro-file after transplantation despite receiving an adult liver graft. These findings suggest that plasma levels of hemostatic proteins are not controlled by the liver. © 2011 by The American Society of Hematology.

Published
2011

8. Lung Transplantation With Grafts From Elderly Donors: A Single-Center Experience

Author

Dezza, M, Parigi, P, Corno, V, Lucianetti, A, Pinelli, D, Zambelli, M, Guizzetti, M, Aluffi, A, Tagliabue, F, Platto, M, Codazzi, D, Triggiani, M, Colledan, M, Dezza MC, Parigi PC, Corno V, Lucianetti A, Pinelli D, Zambelli M, Guizzetti M, Aluffi A, Tagliabue F, Platto M, Codazzi D, Triggiani M, Colledan M, Dezza, M, Parigi, P, Corno, V, Lucianetti, A, Pinelli, D, Zambelli, M, Guizzetti, M, Aluffi, A, Tagliabue, F, Platto, M, Codazzi, D, Triggiani, M, Colledan, M, Dezza MC, Parigi PC, Corno V, Lucianetti A, Pinelli D, Zambelli M, Guizzetti M, Aluffi A, Tagliabue F, Platto M, Codazzi D, Triggiani M, and Colledan M

Abstract

Introduction. Use of extended criteria donors is one of the strategies to face the scarcity of donors for lung transplantation.Methods. Between November 2002 and May 2009, we performed 52 LTs in 50 recipients, 10 of whom (group A) received lungs from donors aged 55 years or older (median, 58.5; range, 56-66 years) for comparison with 28 patients (group B) transplanted with lungs from donors younger than 55 years (median, 25.5; range, 15-54 years). We excluded 9 children and 3 recipients of combined liver plus lung transplantations from the study.Results. Recipient age, gender, and indications for transplantation did not differ significantly between the 2 groups. Neither were there significant differences in PaO2/FiO2 ratios before lung retrieval, or length of the ischemic time The first PaO2/FiO2 on arrival to the intensive care unit (ICU) and the median length of ICU stay were similar. All patients, except 2 who died in the operating theatre, were extubated between 3 and 216 hours after the transplantation. Hospital mortality was similar in both groups: 3 patients in group A and 2 in group B (P = .1). The median portions of the predicted 1-second forced expiratory volume (FEV1) at 6 months after transplantation did not differ in the 2 groups: 62.4% in group A versus 70% in group B (P = .85).Conclusion. Lung grafts from donors older than 55 years can be effectively used for transplantation, thus increasing the total organ pool.

Published
2010

10. LIVER TRANSPLANTATION FOR PRIMARY SCLEROSING CHOLANGITIS IN CHILDREN: A SINGLE CENTER EXPERIENCE

Author

Dezza, M, Corno, V, Stroppa, P, Sonzogni, A, Candusso, M, Tagliabue, F, Pinelli, D, Lucianetti, A, Aluffi, A, Guizzetti, M, Zambelli, M, De Ponti, S, Platto, M, Al Hashash, M, Marin, S, Torre, G, Colledan, M, Dezza MC, Corno V, Stroppa P, Sonzogni A, Candusso M, Tagliabue F, Pinelli D, Lucianetti A, Aluffi A, Guizzetti M, Zambelli M, De Ponti S, Platto M, Al Hashash M, Marin S, Torre G, Colledan M, Dezza, M, Corno, V, Stroppa, P, Sonzogni, A, Candusso, M, Tagliabue, F, Pinelli, D, Lucianetti, A, Aluffi, A, Guizzetti, M, Zambelli, M, De Ponti, S, Platto, M, Al Hashash, M, Marin, S, Torre, G, Colledan, M, Dezza MC, Corno V, Stroppa P, Sonzogni A, Candusso M, Tagliabue F, Pinelli D, Lucianetti A, Aluffi A, Guizzetti M, Zambelli M, De Ponti S, Platto M, Al Hashash M, Marin S, Torre G, and Colledan M

Published
2009

11. LIVER TRANSPLANTATION FOR BILIARY ATRESIA: OUTCOME AT A HIGH VOLUME CENTER

Author

Corno, V, Dezza, M, Stroppa, P, Lucianetti, A, Sonzogni, A, Pinelli, D, Bravi, M, Tagliabue, F, Guizzetti, M, Zambelli, M, Aluffi, A, Platto, M, Codazzi, D, Colledan, M, Corno V, Dezza MC, Stroppa P, Lucianetti A, Sonzogni A, Pinelli D, Bravi M, Tagliabue F, Guizzetti M, Zambelli M, Aluffi A, Platto M, Codazzi D, Colledan M, Corno, V, Dezza, M, Stroppa, P, Lucianetti, A, Sonzogni, A, Pinelli, D, Bravi, M, Tagliabue, F, Guizzetti, M, Zambelli, M, Aluffi, A, Platto, M, Codazzi, D, Colledan, M, Corno V, Dezza MC, Stroppa P, Lucianetti A, Sonzogni A, Pinelli D, Bravi M, Tagliabue F, Guizzetti M, Zambelli M, Aluffi A, Platto M, Codazzi D, and Colledan M

Published
2009

12. VACUUM ASSISTED CLOSURE FOR MANAGEMENT OF COMPLICATED ABDOMINAL WOUNDS AFTER PAEDIATRIC LIVER TRANSPLANTATION

Author

Tagliabue, F, Dezza, M, Corno, V, Lucianetti, A, Pinelli, D, Aluffi, A, Guizzetti, M, Zambelli, M, De Ponti, S, Platto, M, Al Hashash, M, Marin, S, Colledan, M, Tagliabue F, Dezza MC, Corno V, Lucianetti A, Pinelli D, Aluffi A, Guizzetti M, Zambelli M, De Ponti S, Platto M, Al Hashash M, Marin S, Colledan M, Tagliabue, F, Dezza, M, Corno, V, Lucianetti, A, Pinelli, D, Aluffi, A, Guizzetti, M, Zambelli, M, De Ponti, S, Platto, M, Al Hashash, M, Marin, S, Colledan, M, Tagliabue F, Dezza MC, Corno V, Lucianetti A, Pinelli D, Aluffi A, Guizzetti M, Zambelli M, De Ponti S, Platto M, Al Hashash M, Marin S, and Colledan M

Published
2009

15. LIVER TRANSPLANTATION FOR PRIMARY SCLEROSING CHOLANGITIS IN CHILDREN: A SINGLE CENTER EXPERIENCE

Author

Dezza MC, Corno V, Stroppa P, Sonzogni A, Candusso M, Tagliabue F, Pinelli D, Lucianetti A, Aluffi A, Guizzetti M, Zambelli M, De Ponti S, Platto M, Al Hashash M, Marin S, Torre G, Colledan M, Dezza, M, Corno, V, Stroppa, P, Sonzogni, A, Candusso, M, Tagliabue, F, Pinelli, D, Lucianetti, A, Aluffi, A, Guizzetti, M, Zambelli, M, De Ponti, S, Platto, M, Al Hashash, M, Marin, S, Torre, G, and Colledan, M

Subjects
Transplantation, Surgery
Published
2009

18. LIVER TRANSPLANTATION FOR BILIARY ATRESIA: OUTCOME AT A HIGH VOLUME CENTER

Author

Corno, V., Dezza, M. C., Stroppa, P., Lucianetti, A., aurelio sonzogni, Pinelli, D., Bravi, M., Tagliabue, F., Guizzetti, M., Zambelli, M., Aluffi, A., Platto, M., Codazzi, D., Colledan, M., Corno, V, Dezza, M, Stroppa, P, Lucianetti, A, Sonzogni, A, Pinelli, D, Bravi, M, Tagliabue, F, Guizzetti, M, Zambelli, M, Aluffi, A, Platto, M, Codazzi, D, and Colledan, M

Subjects
Transplantation, Surgery

19. Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy

Author

Rosaria Carrinola, P. Paladini, A. Garcia Fernandez, M. Bonizzoli, E. Coluccio, Marco Spada, L. Henrici De Angelis, Alessandro Bertani, M. Valeri, Mauro Rinaldi, P. Di Ciaccio, Simone Ambretti, A. Ricci, Paolo Gaibani, Claudio Farina, L. De Carlis, Giulia Errico, S. D’Arezzo, F. Vailati, M. Canzonieri, M. Caprio, Antonio Daniele Pinna, E. Carrara, Giorgio Palù, G. Feltrin, Francesco Pugliese, C. Rago, M. Ravini, G. Sangiorgi, R. Colombo, P. Cambieri, C. De Cillia, Pier Giulio Conaldi, B. D’Auria, Erminio Torresani, G. P. Gesu, Alessandra Mularoni, A De Gasperi, Giorgio Rossi, A. Peris, Bruno Gridelli, Milena Arghittu, Mauro Salizzoni, Saverio Giuseppe Parisi, Paolo Grossi, M. Platto, V. Sparacino, P. Viale, Lucia Masiero, A. Nanni Costa, M. P. Landini, A. Da Riva, Daniele Dondossola, Antonio Amoroso, Carlo Gagliotti, R. Torelli, D. Adorno, M. Cusi, Floriana Gona, Luigia Rossi, P.B. Berloco, G. Paglialunga, Federico Venuta, Piero Marone, U. Cillo, Francesca Vespasiano, A C Finarelli, L. Fossati, Davide Tosi, A. Maria D’Armini, Federica Maldarelli, Massimiliano Rossi, Federico Rea, Francesco Procaccio, Michele Colledan, Annalisa Pantosti, Filomena Morsillo, C. Vismara, R. Giacometti, Sergio Vesconi, C. Mancini, C. Venditti, Francesca Puoti, Luigi Santambrogio, A. Di Caro, Maria Luisa Moro, F. Stella, E. Cibelli, Monica Monaco, Errico G., Gagliotti C., Monaco M., Masiero L., Gaibani P., Ambretti S., Landini M.P., D'Arezzo S., Di Caro A., Parisi S.G., Palu G., Vespasiano F., Morsillo F., Moro M.L., Procaccio F., Ricci A., Grossi P.A., Pantosti A., Nanni Costa A., Farina C., Vailati F., Gesu G., Vismara C., Arghittu M., Colombo R., Torresani E., Rossi L., Conaldi P.G., Gona F., Cambieri P., Marone P., Venditti C., Fernandez A.G., Mancini C., Cusi M., De Angelis L.H., Fossati L., Finarelli A.C., De Cillia C., Sangiorgi G., Pinna A.D., Stella F., Viale P., Colledan M., Platto M., Bonizzoli M., Peris A., Torelli R., Vesconi S., Cibelli E., De Carlis L., De Gasperi A., Ravini M., Carrinola R., Coluccio E., Dondossola D., Rossi G., Santambrogio L., Tosi D., Feltrin G., Rago C., Cillo U., Da Riva A., Rea F., Sparacino V., Bertani A., Canzonieri M., Gridelli B., Mularoni A., Spada M., Carrara E., D'Armini A.M., Paladini P., Adorno D., Valeri M., Caprio M., Di Ciaccio P., Puoti F., Berloco P., D'Auria B., Maldarelli F., Paglialunga G., Pugliese F., Rossi M., Venuta F., Amoroso A., Giacometti R., Rinaldi M., Salizzoni M., Errico, G, Gagliotti, C, Monaco, M, Masiero, L, Gaibani, P, Ambretti, S, Landini, M, D'Arezzo, S, Di Caro, A, Parisi, S, Palu, G, Vespasiano, F, Morsillo, F, Moro, M, Procaccio, F, Ricci, A, Grossi, P, Pantosti, A, Nanni Costa, A, Farina, C, Vailati, F, Gesu, G, Vismara, C, Arghittu, M, Colombo, R, Torresani, E, Rossi, L, Conaldi, P, Gona, F, Cambieri, P, Marone, P, Venditti, C, Fernandez, A, Mancini, C, Cusi, M, De Angelis, L, Fossati, L, Finarelli, A, De Cillia, C, Sangiorgi, G, Pinna, A, Stella, F, Viale, P, Colledan, M, Platto, M, Bonizzoli, M, Peris, A, Torelli, R, Vesconi, S, Cibelli, E, De Carlis, L, De Gasperi, A, Ravini, M, Carrinola, R, Coluccio, E, Dondossola, D, Rossi, G, Santambrogio, L, Tosi, D, Feltrin, G, Rago, C, Cillo, U, Da Riva, A, Rea, F, Sparacino, V, Bertani, A, Canzonieri, M, Gridelli, B, Mularoni, A, Spada, M, Carrara, E, D'Armini, A, Paladini, P, Adorno, D, Valeri, M, Caprio, M, Di Ciaccio, P, Puoti, F, Berloco, P, D'Auria, B, Maldarelli, F, Paglialunga, G, Pugliese, F, Rossi, M, Venuta, F, Amoroso, A, Giacometti, R, Rinaldi, M, and Salizzoni, M

Subjects
0301 basic medicine, Male, Colonization, Klebsiella pneumoniae, medicine.medical_treatment, Drug Resistance, Transplant Recipient, Liver transplantation, beta-Lactamase, Cohort Studies, 0302 clinical medicine, 80 and over, 030212 general & internal medicine, Prospective Studies, Screening cultures, Prospective cohort study, Child, Aged, 80 and over, biology, Bacterial, Enterobacteriaceae Infections, General Medicine, Middle Aged, Tissue Donors, Infectious Diseases, Italy, Child, Preschool, Female, Infection, Human, Lung Transplantation, Adult, Microbiology (medical), medicine.medical_specialty, Adolescent, 030106 microbiology, Tissue Donor, Bacterial Protein, beta-Lactamases, 03 medical and health sciences, Young Adult, Bacterial Proteins, Internal medicine, Drug Resistance, Bacterial, medicine, Humans, Preschool, Genotyping, Contraindication, Donor–recipient transmission, Aged, business.industry, CPE, Solid organ transplant, Infant, Liver Transplantation, Transplant Recipients, Carbapenem-Resistant Enterobacteriaceae, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Enterobacteriaceae Infection, Transplantation, Prospective Studie, Multilocus sequence typing, Cohort Studie, business
Abstract

Objectives A prospective cohort study was conducted in Italy in order to describe the microbiologic aspects of colonization/infection by carbapenemase-producing Enterobacteriaceae (CPE) in donors and recipients of lung and liver transplants and the possible CPE transmission from donors to recipients. Methods Between 15 January 2014 and 14 January 2015, all recipients of solid organ transplants (SOT) at ten lung and eight liver transplantation centres and the corresponding donors were enrolled. Screening cultures to detect CPE were performed in donors, and screening and clinical cultures in recipients with a 28-day microbiologic follow-up after receipt of SOT. Detection of carbapenemase genes by PCR, genotyping by multilocus sequence typing, and pulsed-field gel electrophoresis and whole-genome sequencing were performed. Results Of 588 screened donors, 3.4% were colonized with CPE. Of the liver first transplant recipients (n = 521), 2.5% were colonized before receipt of SOT and 5% acquired CPE during follow-up. CPE colonization was higher in lung first transplant recipients (n = 111, 2.7% before SOT and 14.4% after SOT). CPE infections occurred in 1.9% and 5.3% of liver or lung recipients, respectively. CPE isolates were mostly Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae belonging to CG258. Three events of donor–recipient CPE transmission, confirmed by whole-genome sequencing and/or pulsed-field gel electrophoresis, occurred in lung recipients: two involving K. pneumoniae sequence type 512 and one Verona integron-encoded metallo-β-lactamase (VIM)-producing Enterobacter aerogenes. Conclusions This study showed a low risk of donor–recipient CPE transmission, indicating that donor CPE colonization does not necessarily represent a contraindication for donation unless colonization regards the organ to be transplanted. Donor and recipient screening remains essential to prevent CPE transmission and cross-infection in transplantation centres.

Published
2019

20. The hemostatic status of pediatric recipients of adult liver grafts suggests that plasma levels of hemostatic proteins are not regulated by the liver

Author

Robert J. Porte, Joost C. M. Meijers, Marco Platto, Michele Colledan, Ton Lisman, Elizabeth B. Haagsma, Groningen Institute for Organ Transplantation (GIOT), Vascular Ageing Programme (VAP), Lisman, T, Platto, M, Meijers, J, Haagsma, E, Colledan, M, Porte, R, ACS - Amsterdam Cardiovascular Sciences, and Vascular Medicine

Subjects
Adult, PHARMACOKINETICS, Adolescent, medicine.medical_treatment, Immunology, Physiology, CHILDREN, Liver transplantation, Biochemistry, Young Adult, Liver Function Tests, Pharmacokinetics, medicine, Humans, HUMAN COAGULATION SYSTEM, Young adult, Aged, Hemostasis, medicine.diagnostic_test, Liver Function Test, business.industry, Cell Biology, Hematology, Plasma levels, Hemostasi, Middle Aged, Blood Coagulation Factors, Liver Transplantation, Transplantation, surgical procedures, operative, Liver, Coagulation, INFANT, Liver function tests, business, Liver Failure, Blood Coagulation Factor, Human
Abstract

Plasma levels of coagulation factors differ profoundly between adults and children, but are remarkably stable throughout adulthood. It is unknown which factors determine plasma levels of coagulation factors in a given individual. We hypothesized that the liver, which synthesizes coagulation factors, also controls plasma levels. We measured a panel of coagulation factors in samples taken from either adults or young children who underwent a liver transplantation with adult donor livers. Samples were taken 1-3 months after transplantation, when the patients were clinically stable with adequate graft function. After liver transplantation, the hemostatic profile of the pediatric group was remarkably different from that of the adult group, and resembled the hemostatic profile of normal children. Thus, children transplanted with an adult liver graft maintain a pediatric hemostatic profile after transplantation despite receiving an adult liver graft. These findings suggest that plasma levels of hemostatic proteins are not controlled by the liver.

Published
2011
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21. Lung Transplantation With Grafts From Elderly Donors: A Single-Center Experience

Author

A. Aluffi, Domenico Pinelli, Alessandro Lucianetti, Daniela Codazzi, M. Triggiani, Fabio Tagliabue, M Guizzetti, M.C. Dezza, Michele Colledan, M. Zambelli, V. Corno, Marco Platto, Piercarlo Parigi, Dezza, M, Parigi, P, Corno, V, Lucianetti, A, Pinelli, D, Zambelli, M, Guizzetti, M, Aluffi, A, Tagliabue, F, Platto, M, Codazzi, D, Triggiani, M, and Colledan, M

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Tissue Donor, Liver transplantation, Single Center, Group B, law.invention, Young Adult, law, Cause of Death, Forced Expiratory Volume, medicine, Humans, Lung transplantation, Age Factor, Young adult, Aged, Transplantation, Cardiopulmonary Bypass, Lung, Cardiopulmonary Bypa, business.industry, Patient Selection, Age Factors, Middle Aged, respiratory system, Intensive care unit, Tissue Donors, Liver Transplantation, respiratory tract diseases, Surgery, Stroke, Treatment Outcome, medicine.anatomical_structure, Female, business, Human, Lung Transplantation
Abstract

Introduction Use of extended criteria donors is one of the strategies to face the scarcity of donors for lung transplantation. Methods Between November 2002 and May 2009, we performed 52 LTs in 50 recipients, 10 of whom (group A) received lungs from donors aged 55 years or older (median, 58.5; range, 56–66 years) for comparison with 28 patients (group B) transplanted with lungs from donors younger than 55 years (median, 25.5; range, 15–54 years). We excluded 9 children and 3 recipients of combined liver plus lung transplantations from the study. Results Recipient age, gender, and indications for transplantation did not differ significantly between the 2 groups. Neither were there significant differences in PaO2/FiO2 ratios before lung retrieval, or length of the ischemic time The first PaO2/FiO2 on arrival to the intensive care unit (ICU) and the median length of ICU stay were similar. All patients, except 2 who died in the operating theatre, were extubated between 3 and 216 hours after the transplantation. Hospital mortality was similar in both groups: 3 patients in group A and 2 in group B (P = .1). The median portions of the predicted 1-second forced expiratory volume (FEV1) at 6 months after transplantation did not differ in the 2 groups: 62.4% in group A versus 70% in group B (P = .85). Conclusion Lung grafts from donors older than 55 years can be effectively used for transplantation, thus increasing the total organ pool.

Published
2010
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22. Multimodal treatment of colorectal postsurgical leaks: long-term results of the over-the-scope clip (OTSC) application.

Author

Chiari D, LA Raja C, Mangiavillano B, Veronesi P, Platto M, and Zuliani W

Subjects
Anastomotic Leak surgery, Combined Modality Therapy, Endoscopy, Gastrointestinal methods, Humans, Retrospective Studies, Colorectal Neoplasms surgery, Surgical Instruments
Abstract

Background: Postsurgical anastomotic colorectal leaks often require a surgical second look with a definite morbidity and the risk of delaying adjuvant treatment. The aim of this study was to analyse the long-term results of the endoscopic closure of colorectal leak following low anterior resection (LAR) using the over-the-scope (Ovesco™; Ovesco Endoscopy AG, Tübingen, Germany) clip., Methods: Patients who were submitted to endoscopic closure of a colorectal leak of maximum 2 cm with an Ovesco™ clip following LAR from 2016 to 2018 were enrolled in this retrospective single-center study (Humanitas Mater Domini Clinical Institute, Italy). The follow-up was obtained through radiologic and clinic assessments., Results: In the analyzed study period, 48 patients were submitted to LAR. Six patients were enrolled in the study. The median diameter of the leak was 7 mm. 14/6t or 12/6t OTSC ® clip was applied. Three patients were managed exclusively endoscopically, 2 of them had a protective ileostomy; 3 patients underwent urgent laparotomy with ostomy and then underwent endoscopic procedure. Complete healing was reached in all patients in a median of 23 days. Adjuvant chemotherapy was indicated and performed in 4 patients after a median of 64 days from the surgery. Among the 5 carriers of an ostomy, 4 patients underwent recanalization. The median follow-up was 21.5 months. During the follow-up no leak reoccurrence or complications were reported., Conclusions: In the multimodal management of anastomotic leaks following LAR, Ovesco™ clipping system appears a safe and effective technique in the closure of small leaks (<2 cm), allowing an early recanalization of the bowel and not delaying adjuvant chemotherapy when indicated.

Published
2022
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23. Intention to Split Policy: A Successful Strategy in a Combined Pediatric and Adult Liver Transplant Center.

Author

Battula NR, Platto M, Anbarasan R, Perera MT, Ong E, Roll GR, Ferraz Neto BH, Mergental H, Isaac J, Muiesan P, Sharif K, and Mirza DF

Subjects
Adult, Age Factors, Child, Child, Preschool, Cohort Studies, Databases, Factual, Graft Rejection, Graft Survival, Health Policy, Humans, Kaplan-Meier Estimate, Liver Transplantation mortality, Proportional Hazards Models, Retrospective Studies, Survival Rate, Tissue Donors, Treatment Outcome, United Kingdom, Academic Medical Centers, Liver Transplantation methods, Policy Making, Tissue and Organ Procurement organization & administration, Waiting Lists
Abstract

Objective: The primary aim of this study is to evaluate the role of split liver transplantation (SLT) in a combined pediatric and adult liver transplant center. The secondary aim is to reflect on our clinical practice and discuss strategies to build a successful split program using an "intention to split policy.", Background: SLT is an established procedure to expand the organ pool and reduce wait list mortality; however, technical and logistic issues are limiting factors., Methods: Prospectively collected data and outcomes of SLT procedures performed between November 1992 and March 2014 were analyzed retrospectively. To assess the effect of standardization and learning curve, the experience was divided into 2 time periods., Results: Out of 3449 liver transplant procedures performed, 516(15%) were SLT. The recipients included 266 children (290 grafts; 56%) and 212 adults (226 grafts; 44%). The median donor age was 25(7-63 years) and the median weight was 70(22-111 kg). The cold and warm ischemic times improved significantly during the second period (SP) (2001-2014). With experience, there was a significant reduction in the biliary complications for both grafts. The introduction of "intention to split policy" resulted in a significantly increased usage of SLT. There was no mortality on the pediatric wait list for last 4 years. Over the last decade 65% of our pediatric transplants were SLT. The overall 1-, 5-, 10-year patient and graft survival of left graft recipients was 91%, 90%, and 89% and 90%, 87%, and 86%. For right grafts it was 87%, 82%, and 81% and 82%, 81%, and 79%, respectively., Conclusions: SLT is an effective surgical strategy to meet the demands in a combined adult and pediatric transplant center. Good outcomes can be achieved with a standardized technique.

Published
2017
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24. A rare cause of massive hepatomegaly.

Author

Tariciotti L, Platto M, and Bramhall SR

Subjects
Hemangioma diagnosis, Hemangioma diagnostic imaging, Hemangioma surgery, Hepatomegaly diagnostic imaging, Hepatomegaly surgery, Humans, Liver Neoplasms diagnosis, Liver Neoplasms diagnostic imaging, Liver Neoplasms surgery, Liver Transplantation, Male, Middle Aged, Quality of Life, Radiography, Treatment Outcome, Hepatomegaly diagnosis, Hepatomegaly etiology
Published
2012
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25. The hemostatic status of pediatric recipients of adult liver grafts suggests that plasma levels of hemostatic proteins are not regulated by the liver.

Author

Lisman T, Platto M, Meijers JC, Haagsma EB, Colledan M, and Porte RJ

Subjects
Adolescent, Adult, Aged, Humans, Infant, Liver Failure blood, Liver Failure surgery, Liver Function Tests, Middle Aged, Young Adult, Blood Coagulation Factors metabolism, Hemostasis physiology, Liver physiology, Liver Transplantation physiology
Abstract

Plasma levels of coagulation factors differ profoundly between adults and children, but are remarkably stable throughout adulthood. It is unknown which factors determine plasma levels of coagulation factors in a given individual. We hypothesized that the liver, which synthesizes coagulation factors, also controls plasma levels. We measured a panel of coagulation factors in samples taken from either adults or young children who underwent a liver transplantation with adult donor livers. Samples were taken 1-3 months after transplantation, when the patients were clinically stable with adequate graft function. After liver transplantation, the hemostatic profile of the pediatric group was remarkably different from that of the adult group, and resembled the hemostatic profile of normal children. Thus, children transplanted with an adult liver graft maintain a pediatric hemostatic profile after transplantation despite receiving an adult liver graft. These findings suggest that plasma levels of hemostatic proteins are not controlled by the liver.

Published
2011
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26. The relationship of pain and deformity of the rheumatoid foot to gait and an index of functional ambulation.

Author

Platto MJ, O'Connell PG, Hicks JE, and Gerber LH

Subjects
Adult, Aged, Arthritis, Rheumatoid pathology, Female, Foot pathology, Humans, Male, Middle Aged, Surveys and Questionnaires, Arthritis, Rheumatoid physiopathology, Foot physiopathology, Gait, Pain, Walking
Abstract

We evaluated the relationships among pain, structural deformity of the foot, 4 variables of gait, and an index of functional ambulation in 31 patients with rheumatoid arthritis. We saw significant correlations between the ambulation index and all gait variables (p less than 0.005). For the group as a whole, pain in the foot did not correlate with structural deformity. However, when patients were grouped according to the relative preponderance of pain or deformity and duration of disease, we found correlations between the sites of pain and deformity. Pain in the lower extremity, and the knee or hindfoot separately, showed correlations with functional ambulation. Foot deformity did not correlate with functional ambulation at all. Foot pain correlated well with velocity and especially stride length (p less than 0.005), and not as well with cadence and double stance time. Fewer correlations were seen between foot deformity and gait. In general, hindfoot disease was associated with greater impairment of gait and mobility than forefoot disease.

Published
1991

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