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1. Model-based Estimation of AV-nodal Refractory Period and Conduction Delay Trends from ECG

Author

Karlsson, Mattias, Platonov, Pyotr G, Ulimoen, Sara R., Sandberg, Frida, and Wallman, Mikael

Subjects
Statistics - Applications, Quantitative Biology - Tissues and Organs
Abstract

Atrial fibrillation (AF) is the most common arrhythmia, associated with significant burdens to patients and the healthcare system. The atrioventricular (AV) node plays a vital role in regulating heart rate during AF, but is often insufficient in regards to maintaining a healthy heart rate. Thus, the AV node properties are modified using rate-control drugs. Hence, quantifying individual differences in diurnal and short-term variability of AV-nodal function could aid in personalized treatment selection. This study presents a novel methodology for estimating the refractory period (RP) and conduction delay (CD) trends and their uncertainty in the two pathways of the AV node during 24 hours using non-invasive data. This was achieved using a network model together with a problem-specific genetic algorithm and an approximate Bayesian computation algorithm. Diurnal and short-term variability in the estimated RP and CD was quantified by the difference between the daytime and nighttime estimates and by the Kolmogorov-Smirnov distance between adjacent 10-minute segments in the 24-hour trends. Holter ECGs from 51 patients with permanent AF during baseline were analyzed, and the predictive power of variations in RP and CD on the resulting heart rate reduction after treatment with four rate control drugs was investigated. Diurnal variability yielded no correlation to treatment outcome, and no prediction of drug outcome was possible using the machine learning tools. However, a correlation between the short-term variability for the RP and CD in the fast pathway and resulting heart rate reduction during treatment with metoprolol ($\rho=0.48, p<0.005$ in RP, $\rho=0.35, p<0.05$ in CD) were found. The proposed methodology enables non-invasive estimation of the AV node properties during 24 hours, which may have the potential to assist in treatment selection., Comment: 12 pages, 6 figures, 2 tables, 1 pseudocode

Published
2023

2. ECG-based estimation of respiratory modulation of AV nodal conduction during atrial fibrillation

Author

Plappert, Felix, Engström, Gunnar, Platonov, Pyotr G., Wallman, Mikael, and Sandberg, Frida

Subjects
Physics - Medical Physics, Electrical Engineering and Systems Science - Signal Processing, Quantitative Biology - Tissues and Organs
Abstract

Information about autonomic nervous system (ANS) activity may be valuable for personalized atrial fibrillation (AF) treatment but is not easily accessible from the ECG. In this study, we propose a new approach for ECG-based assessment of respiratory modulation in AV nodal refractory period and conduction delay. A 1-dimensional convolutional neural network (1D-CNN) was trained to estimate respiratory modulation of AV nodal conduction properties from 1-minute segments of RR series, respiration signals, and atrial fibrillatory rates (AFR) using synthetic data that replicates clinical ECG-derived data. The synthetic data were generated using a network model of the AV node and 4 million unique model parameter sets. The 1D-CNN was then used to analyze respiratory modulation in clinical deep breathing test data of 28 patients in AF, where a ECG-derived respiration signal was extracted using a novel approach based on periodic component analysis. We demonstrated using synthetic data that the 1D-CNN can predict the respiratory modulation from RR series alone ($\rho$ = 0.805) and that the addition of either respiration signal ($\rho$ = 0.830), AFR ($\rho$ = 0.837), or both ($\rho$ = 0.855) improves the prediction. Results from analysis of clinical ECG data of 20 patients with sufficient signal quality suggest that respiratory modulation decreased in response to deep breathing for five patients, increased for five patients, and remained similar for ten patients, indicating a large inter-patient variability., Comment: 20 pages, 7 figures, 5 tables

Published
2023
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7. ISE/ISHNE Expert Consensus Statement on ECG Diagnosis of Left Ventricular Hypertrophy: The Change of the Paradigm. The joint paper of the International Society of Electrocardiology and the International Society for Holter Monitoring and Noninvasive Electrocardiology

Author

Bacharova, Ljuba, Chevalier, Philippe, Gorenek, Bulent, Jons, Christian, Li, Yi-Gang, Locati, Emanuela T., Maanja, Maren, Pérez-Riera, Andrés Ricardo, Platonov, Pyotr G., Ribeiro, Antonio Luiz P., Schocken, Douglas, Soliman, Elsayed Z., Svehlikova, Jana, Tereshchenko, Larisa G., Ugander, Martin, Varma, Niraj, Zaklyazminskaya, Elena, and Ikeda, Takanori

Published
2023
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8. Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes

Author

Myadam, Rahul, Crawford, Thomas C., Bogun, Frank M., Gu, Xiaokui, Ellenbogen, Kenneth A., Jasti, Shilpa, Chicos, Alexandru B., Roukoz, Henri, Zimetbaum, Peter J., Kalbfleisch, Steven J., Murgatroyd, Francis D., Steckman, David A., Rosenfeld, Lynda E., Garlitski, Ann C., Soejima, Kyoko, Bhan, Adarsh K., Vedantham, Vasanth, Dickfeld, Timm-Michael L., De Lurgio, David B., Platonov, Pyotr G., Zipse, Matthew M., Nishiuchi, Suguru, Ortman, Matthew L., Narasimhan, Calambur, Patton, Kristen K., Rosenthal, David G., Mukerji, Siddharth S., Hoogendoorn, Jarieke C., Zeppenfeld, Katja, Sauer, William H., and Kron, Jordana

Published
2023
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9. Prognostic value of early sustained ventricular arrhythmias in ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: A substudy of VALIDATE-SWEDEHEART trial

Author

Demidova, Marina M., Rylance, Rebecca, Koul, Sasha, Dworeck, Christian, James, Stefan, Aasa, Mikael, Hamid, Mehmet, Swahn, Eva, Hambraeus, Kristina, Danielewicz, Mikael, Linder, Rikard, Fröbert, Ole, Grimfjärd, Per, Stewart, Jason, Henareh, Loghman, Andersson, Jonas, Wagner, Henrik, Erlinge, David, and Platonov, Pyotr G.

Published
2023
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10. Age-Stratified Clinical Outcome in Patients with Known Heart Failure Who Receive Pacemaker, Resynchronization Therapy, or Defibrillator Implants.

Author

Rorsman, Cecilia, Farouq, Maiwand, Marinko, Sofia, Platonov, Pyotr G., and Borgquist, Rasmus

Subjects
CARDIAC pacing, CARDIAC pacemakers, MYOCARDIAL ischemia, CORONARY disease, HEART failure patients, HEART failure
Abstract

Introduction: Patients with heart failure (HF) and bradycardia may be eligible for different types of cardiac implantable electronic devices (CIED), depending on the presence of atrioventricular conduction disease, age, and comorbidities. We aimed to assess the prognosis for these patients, after CIED implantation, stratified for the type of CIED device. Methods: All patients with preexisting HF diagnosis who received a CIED with a right ventricular lead during the period 2005–2018 in Sweden were identified via the pacemaker registry. Data were crossmatched with the population registry and national disease registries. The outcome was 5-year risk of HF hospitalization and mortality. Results: A total of 37,745 patients were included in the study. Comparing demographics for implantable cardioverter defibrillator versus pacemaker implants, median age was 66 years versus 83 years, 20% versus 41% were female, 64% versus 50% had ischemic heart disease, and 35% versus 67% had atrial fibrillation (all p < 0.001). Five-year mortality was highest in single-chamber pacemaker recipients (61% compared to average 40%, p < 0.001), but the proportion of cardiovascular mortality was highest for cardiac resynchronization therapy (CRT) recipients (68% vs. 63% p < 0.001). Adjusted mortality was higher for pacemaker patients in all age decile groups (ranging from <60 to >90 years old, all p < 0.001), HF hospitalization occurred in 28% (dual-chamber pacemaker) to 39% (CRT-P) of patients, and cause of death was HF in 15% (dual-chamber pacemaker) to 25% (CRT-D), all p < 0.001. Conclusion: In this large real-world cohort of CIED-treated patients with prior HF, demography and mortality data indicate that clinicians chose devices according to the overall status of the patient. HF-related events occurred in all groups but were more common in CRT-treated patients. [ABSTRACT FROM AUTHOR]

Published
2024
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13. 2021 ISHNE/HRS/EHRA/APHRS Collaborative Statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society

Author

Varma, Niraj, Cygankiewicz, Iwona, Turakhia, Mintu P., Heidbuchel, Hein, Hu, Yufeng, Chen, Lin Yee, Couderc, Jean-Philippe, Cronin, Edmond M., Estep, Jerry D., Grieten, Lars, Lane, Deirdre A., Mehra, Reena, Page, Alex, Passman, Rod, Piccini, Jonathan P., Piotrowicz, Ewa, Piotrowicz, Ryszard, Platonov, Pyotr G., Ribeiro, Antonio Luiz, Rich, Robert E., Russo, Andrea M., Slotwiner, David, Steinberg, Jonathan S., and Svennberg, Emma

Published
2021
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14. Natural Course of Electrocardiographic Features in Arrhythmogenic Right Ventricular Cardiomyopathy and Their Relation to Ventricular Arrhythmic Events

Author

Onderzoek Precision medicine, Team Medisch, Circulatory Health, Svensson, Anneli, Jensen, Henrik Kjaerulf, Boonstra, Machteld J., Tétreault-Langlois, Marianne, Dahlberg, Pia, Bundgaard, Henning, Christensen, Alex Hørby, Rylance, Rebecca T., Svendsen, Jesper H., Cadrin-Tourigny, Julia, Te Riele, Anneline S.J.M., Platonov, Pyotr G., Onderzoek Precision medicine, Team Medisch, Circulatory Health, Svensson, Anneli, Jensen, Henrik Kjaerulf, Boonstra, Machteld J., Tétreault-Langlois, Marianne, Dahlberg, Pia, Bundgaard, Henning, Christensen, Alex Hørby, Rylance, Rebecca T., Svendsen, Jesper H., Cadrin-Tourigny, Julia, Te Riele, Anneline S.J.M., and Platonov, Pyotr G.

Published
2024

15. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Arts Assistenten Cardiologie, Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Team Onderzoek, Carrick, Richard T, De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P, Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A M, Davies, Brianna, Seifer, Colette, Roberts, Jason D, Healey, Jeff S, MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J, Targetti, Mattia, Calò, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K, Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E, Di Marco, Andrea, Jordà, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Delinière, Antoine, Biernacka, Elżbieta K, van Tintelen, J Peter, Platonov, Pyotr G, Olivotto, Iacopo, Saguner, Ardan M, Haugaa, Kristina H, Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D, Te Riele, Anneline S J M, Wu, Katherine C, Calkins, Hugh, James, Cynthia A, Cadrin-Tourigny, Julia, Arts Assistenten Cardiologie, Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Team Onderzoek, Carrick, Richard T, De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P, Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A M, Davies, Brianna, Seifer, Colette, Roberts, Jason D, Healey, Jeff S, MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J, Targetti, Mattia, Calò, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K, Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E, Di Marco, Andrea, Jordà, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Delinière, Antoine, Biernacka, Elżbieta K, van Tintelen, J Peter, Platonov, Pyotr G, Olivotto, Iacopo, Saguner, Ardan M, Haugaa, Kristina H, Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D, Te Riele, Anneline S J M, Wu, Katherine C, Calkins, Hugh, James, Cynthia A, and Cadrin-Tourigny, Julia

Published
2024

16. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Carrick, Richard T., De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P., Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A. M., Davies, Brianna, Seifer, Colette, Roberts, Jason D., Healey, Jeff S., MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J., Targetti, Mattia, Calo, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K., Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E., Di Marco, Andrea, Jorda, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Deliniere, Antoine, Biernacka, Elzbieta K., van Tintelen, J. Peter, Platonov, Pyotr G., Olivotto, Iacopo, Saguner, Ardan M., Haugaa, Kristina H., Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D., te Riele, Anneline S. J. M., Wu, Katherine C., Calkins, Hugh, James, Cynthia A., Cadrin-Tourigny, Julia, Carrick, Richard T., De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P., Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A. M., Davies, Brianna, Seifer, Colette, Roberts, Jason D., Healey, Jeff S., MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J., Targetti, Mattia, Calo, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K., Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E., Di Marco, Andrea, Jorda, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Deliniere, Antoine, Biernacka, Elzbieta K., van Tintelen, J. Peter, Platonov, Pyotr G., Olivotto, Iacopo, Saguner, Ardan M., Haugaa, Kristina H., Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D., te Riele, Anneline S. J. M., Wu, Katherine C., Calkins, Hugh, James, Cynthia A., and Cadrin-Tourigny, Julia

Abstract

Background and Aims Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences in utilization of primary prevention ICDs and survival free from sustained ventricular arrhythmia (VA) in ARVC.Methods This was a retrospective analysis of ARVC patients without prior VA enrolled in clinical registries from 11 countries throughout Europe and North America. Patients were classified according to whether they received treatment in North America or Europe and were further stratified by baseline predicted VA risk into low- (<10%/5 years), intermediate- (10%-25%/5 years), and high-risk (>25%/5 years) groups. Differences in ICD implantation and survival free from sustained VA events (including appropriate ICD therapy) were assessed.Results One thousand ninety-eight patients were followed for a median of 5.1 years; 554 (50.5%) received a primary prevention ICD, and 286 (26.0%) experienced a first VA event. After adjusting for baseline risk factors, North Americans were more than three times as likely to receive ICDs {hazard ratio (HR) 3.1 [95% confidence interval (CI) 2.5, 3.8]} but had only mildly increased risk for incident sustained VA [HR 1.4 (95% CI 1.1, 1.8)]. North Americans without ICDs were at higher risk for incident sustained VA [HR 2.1 (95% CI 1.3, 3.4)] than Europeans.Conclusions North American ARVC patients were substantially more likely than Europeans to receive primary prevention ICDs across all arrhythmic risk strata. A lower rate of ICD implantation in Europe was not associated with a higher rate of VA events in those without ICDs., Funding Agencies|Leonie-Wild Foundation; Leyla Erkan Family Fund for ARVD Research; Hugh Calkins, Marvin H. Weiner, and Jacqueline J. Bernstein Cardiac Arrhythmia Center; Dr Francis P. Chiaramonte Private Foundation; Dr Satish, Rupal, and Robin Shah ARVD Fund at Johns Hopkins; Bogle Foundation; Campanella Family; Patrick J. Harrison Family; Peter French Memorial Foundation; ALF foundation; Wilmerding Endowments; NIH [T32HL007227]; NIH Loan Repayment Program [L30HL165535]; Philippa and Marvin Carsley Cardiology Research Chair; Montreal Heart Institute Foundation; Norwegian Research Council [309762, 288438, 298736]; ZonMW Off Road personal research grant; Dutch Heart Association; Netherlands Cardiovascular Research Initiative - Dutch Heart Foundation [2018-30 PREDICT2]; Dutch Heart Foundation; Netherlands Heart Institute [06901]; Georg and Bertha Schwyzer-Winiker Foundation; Baugarten Foundation; Swiss National Science Foundation; Swiss Heart Foundation; USZ Foundation; Daniel Bravo Foundation; Spanish Society of Cardiology; Sociedad Espanola de Cardiologia; Swedish Heart Lung Foundation

Published
2024
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17. The ABC-Stroke Risk Score and Effects of Atrial Fibrillation Screening on Stroke Prevention:Results From the Randomized LOOP Study

Author

Xing, Lucas Yixi, Diederichsen, Søren Zöga, Højberg, Søren, Krieger, Derk W., Graff, Claus, Frikke-Schmidt, Ruth, Platonov, Pyotr G., Olesen, Morten S., Brandes, Axel, Køber, Lars, Haugan, Ketil Jørgen, Svendsen, Jesper Hastrup, Xing, Lucas Yixi, Diederichsen, Søren Zöga, Højberg, Søren, Krieger, Derk W., Graff, Claus, Frikke-Schmidt, Ruth, Platonov, Pyotr G., Olesen, Morten S., Brandes, Axel, Køber, Lars, Haugan, Ketil Jørgen, and Svendsen, Jesper Hastrup

Abstract

Background The ABC‐stroke score is a risk scheme for prediction of stroke or systemic embolism (SE) in atrial fibrillation (AF). This study sought to examine whether the score could be useful in predicting stroke in AF‐naïve individuals and risk stratifying for AF screening. Methods and Results The LOOP (Atrial Fibrillation Detected by Continuous ECG Monitoring Using Implantable Loop Recorder to Prevent Stroke in High‐Risk Individuals) study randomized 6004 AF‐naïve individuals aged 70 to 90 years with stroke risk factors to either screening with an implantable loop recorder and anticoagulation upon detection of new‐onset AF episodes ≥6 minutes, or usual care. A total of 5781 participants had available ABC‐stroke score at baseline and were included in this secondary analysis: 4170 (72.1%) with an estimated stroke/SE risk ≤1%/year versus 1611 (27.9%) with an estimated stroke/SE risk >1%/year. Having an annual ABC‐stroke risk >1% was associated with stroke/SE, stroke/SE/cardiovascular death, and all‐cause death (hazard ratio, 1.82 [95% CI, 1.44–2.21], 2.17 [95% CI, 1.80–2.62], and 2.19 [95% CI, 1.87–2.56], respectively). For screening with implantable loop recorder versus usual care, no significant reduction in these study outcomes was obtained in any ABC‐stroke risk groups (P>0.0500 for all), with no signal toward interaction (Pinteraction>0.2500 for all). Similar findings were yielded when assessing the ABC‐stroke score as a continuous variable. Conclusions In an elderly, AF‐naïve population with additional stroke risk factors, a higher ABC‐stroke score could identify individuals with increased stroke risk. However, this risk score may not be useful in pinpointing those more likely to benefit from AF screening and subsequent preventive treatment. These findings should be considered as hypothesis generating and warrant further study., BACKGROUND: The ABC-stroke score is a risk scheme for prediction of stroke or systemic embolism (SE) in atrial fibrillation (AF). This study sought to examine whether the score could be useful in predicting stroke in AF-naïve individuals and risk stratifying for AF screening. METHODS AND RESULTS: The LOOP (Atrial Fibrillation Detected by Continuous ECG Monitoring Using Implantable Loop Recorder to Prevent Stroke in High-Risk Individuals) study randomized 6004 AF-naïve individuals aged 70 to 90 years with stroke risk factors to either screening with an implantable loop recorder and anticoagulation upon detection of new-onset AF episodes ≥6 minutes, or usual care. A total of 5781 participants had available ABC-stroke score at baseline and were included in this secondary analysis: 4170 (72.1%) with an estimated stroke/SE risk ≤1%/year versus 1611 (27.9%) with an estimated stroke/SE risk >1%/year. Having an annual ABC-stroke risk >1% was associated with stroke/SE, stroke/SE/cardiovascular death, and all-cause death (hazard ratio, 1.82 [95% CI, 1.44-2.21], 2.17 [95% CI, 1.80-2.62], and 2.19 [95% CI, 1.87-2.56], respectively). For screening with implantable loop recorder versus usual care, no significant reduction in these study outcomes was obtained in any ABC-stroke risk groups (P>0.0500 for all), with no signal toward interaction (Pinteraction>0.2500 for all). Similar findings were yielded when assessing the ABC-stroke score as a continuous variable. CONCLUSIONS: In an elderly, AF-naïve population with additional stroke risk factors, a higher ABC-stroke score could identify individuals with increased stroke risk. However, this risk score may not be useful in pinpointing those more likely to benefit from AF screening and subsequent preventive treatment. These findings should be considered as hypothesis generating and warrant further study. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier: NCT02036450.

Published
2024

21. The ABC‐Stroke Risk Score and Effects of Atrial Fibrillation Screening on Stroke Prevention: Results From the Randomized LOOP Study

Author

Xing, Lucas Yixi, primary, Diederichsen, Søren Zöga, additional, Højberg, Søren, additional, Krieger, Derk W., additional, Graff, Claus, additional, Frikke‐Schmidt, Ruth, additional, Platonov, Pyotr G., additional, Olesen, Morten S., additional, Brandes, Axel, additional, Køber, Lars, additional, Haugan, Ketil Jørgen, additional, and Svendsen, Jesper Hastrup, additional

Published
2024
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22. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Carrick, Richard T, primary, De Marco, Corrado, additional, Gasperetti, Alessio, additional, Bosman, Laurens P, additional, Gourraud, Jean-Baptiste, additional, Trancuccio, Alessandro, additional, Mazzanti, Andrea, additional, Murray, Brittney, additional, Pendleton, Catherine, additional, Tichnell, Crystal, additional, Tandri, Harikrishna, additional, Zeppenfeld, Katja, additional, Wilde, Arthur A M, additional, Davies, Brianna, additional, Seifer, Colette, additional, Roberts, Jason D, additional, Healey, Jeff S, additional, MacIntyre, Ciorsti, additional, Alqarawi, Wael, additional, Tadros, Rafik, additional, Cutler, Michael J, additional, Targetti, Mattia, additional, Calò, Leonardo, additional, Vitali, Francesco, additional, Bertini, Matteo, additional, Compagnucci, Paolo, additional, Casella, Michela, additional, Dello Russo, Antonio, additional, Cappelletto, Chiara, additional, De Luca, Antonio, additional, Stolfo, Davide, additional, Duru, Firat, additional, Jensen, Henrik K, additional, Svensson, Anneli, additional, Dahlberg, Pia, additional, Hasselberg, Nina E, additional, Di Marco, Andrea, additional, Jordà, Paloma, additional, Arbelo, Elena, additional, Moreno Weidmann, Zoraida, additional, Borowiec, Karolina, additional, Delinière, Antoine, additional, Biernacka, Elżbieta K, additional, van Tintelen, J Peter, additional, Platonov, Pyotr G, additional, Olivotto, Iacopo, additional, Saguner, Ardan M, additional, Haugaa, Kristina H, additional, Cox, Moniek, additional, Tondo, Claudio, additional, Merlo, Marco, additional, Krahn, Andrew D, additional, te Riele, Anneline S J M, additional, Wu, Katherine C, additional, Calkins, Hugh, additional, James, Cynthia A, additional, and Cadrin-Tourigny, Julia, additional

Published
2024
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23. Reply

Author

Myadam, Rahul, primary, Crawford, Thomas C., additional, Bogun, Frank M., additional, Gu, Xiaokui, additional, Ellenbogen, Kenneth A., additional, Jasti, Shilpa, additional, Chicos, Alexandru B., additional, Roukoz, Henri, additional, Zimetbaum, Peter J., additional, Kalbfleisch, Steven J., additional, Murgatroyd, Francis D., additional, Steckman, David A., additional, Rosenfeld, Lynda E., additional, Garlitski, Ann C., additional, Soejima, Kyoko, additional, Bhan, Adarsh K., additional, Vedantham, Vasanth, additional, Dickfeld, Timm-Michael L., additional, De Lurgio, David B., additional, Platonov, Pyotr G., additional, Zipse, Matthew M., additional, Nishiuchi, Suguru, additional, Ortman, Matthew L., additional, Narasimhan, Calambur, additional, Patton, Kristen K., additional, Rosenthal, David G., additional, Mukerji, Siddharth S., additional, Hoogendoorn, Jarieke C., additional, Zeppenfeld, Katja, additional, Sauer, William H., additional, and Kron, Jordana, additional

Published
2023
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24. P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research—A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology

Author

Chen, Lin Yee, Ribeiro, Antonio Luiz Pinho, Platonov, Pyotr G., Cygankiewicz, Iwona, Soliman, Elsayed Z., Gorenek, Bulent, Ikeda, Takanori, Vassilikos, Vassilios P., Steinberg, Jonathan S., Varma, Niraj, Bayés-de-Luna, Antoni, and Baranchuk, Adrian

Published
2022
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27. ISE/ISHNE expert consensus statement on the ECG diagnosis of left ventricular hypertrophy: The change of the paradigm

Author

Bacharova, Ljuba, primary, Chevalier, Philippe, additional, Gorenek, Bulent, additional, Jons, Christian, additional, Li, Yi‐Gang, additional, Locati, Emanuela T., additional, Maanja, Maren, additional, Pérez‐Riera, Andrés Ricardo, additional, Platonov, Pyotr G., additional, Ribeiro, Antonio Luiz Pinho, additional, Schocken, Douglas, additional, Soliman, Elsayed Z., additional, Svehlikova, Jana, additional, Tereshchenko, Larisa G., additional, Ugander, Martin, additional, Varma, Niraj, additional, Elena, Zaklyazminskaya, additional, and Ikeda, Takanori, additional

Published
2023
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31. Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Collaboration

Author

Cadrin-Tourigny, Julia, Bosman, Laurens P., Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Lie, Øyvind H., Saguner, Ardan M., Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, van den Berg, Maarten P., Asselbergs, Folkert W., Wilde, Arthur A.M., Krahn, Andrew D., Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L., Kamel, Ihab R., Crosson, Jane E., Judge, Daniel P., Yap, Sing-Chien, Van der Heijden, Jeroen F., Tandri, Harikrishna, Jongbloed, Jan D.H., van Tintelen, J. Peter, Platonov, Pyotr G., Duru, Firat, Haugaa, Kristina H., Khairy, Paul, Hauer, Richard N.W., Calkins, Hugh, te Riele, Anneline S.J.M., and James, Cynthia A.

Published
2021
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36. Model-based estimation of AV-nodal refractory period and conduction delay trends from ECG.

Author

Karlsson, Mattias, Platonov, Pyotr G., Ulimoen, Sara R., Sandberg, Frida, and Wallman, Mikael

Subjects
ATRIOVENTRICULAR node, HEART beat, ATRIAL fibrillation, GENETIC algorithms, ARRHYTHMIA
Abstract

Introduction: Atrial fibrillation (AF) is the most common arrhythmia, associated with significant burdens to patients and the healthcare system. The atrioventricular (AV) node plays a vital role in regulating heart rate during AF by filtering electrical impulses from the atria. However, it is often insufficient in regards to maintaining a healthy heart rate, thus the AV node properties are modified using rate-control drugs. Moreover, treatment selection during permanent AF is currently done empirically. Quantifying individual differences in diurnal and short-term variability of AV-nodal function could aid in personalized treatment selection. Methods: This study presents a novel methodology for estimating the refractory period (RP) and conduction delay (CD) trends, and their uncertainty in the two pathways of the AV node during 24 h using non-invasive data. This was achieved by utilizing a network model together with a problem-specific genetic algorithm and an approximate Bayesian computation algorithm. Diurnal variability in the estimated RP and CD was quantified by the difference between the daytime and nighttime estimates, and short-term variability was quantified by the Kolmogorov-Smirnov distance between adjacent 10-min segments in the 24-h trends. Additionally, the predictive value of the derived parameter trends regarding drug outcome was investigated using several machine learning tools. Results: Holter electrocardiograms from 51 patients with permanent AF during baseline were analyzed, and the predictive power of variations in RP and CD on the resulting heart rate reduction after treatment with four rate control drugs was investigated. Diurnal variability yielded no correlation to treatment outcome, and no prediction of drug outcome was possible using the machine learning tools. However, a correlation between the short-term variability for the RP and CD in the fast pathway and resulting heart rate reduction during treatment with metoprolol (ρ = 0.48, p < 0.005 in RP, ρ = 0.35, p < 0.05 in CD) were found. Discussion: The proposed methodology enables non-invasive estimation of the AV node properties during 24 h, which--indicated by the correlation between the short-term variability and heart rate reduction--may have the potential to assist in treatment selection. [ABSTRACT FROM AUTHOR]

Published
2024
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37. ISE/ISHNE expert consensus statement on the ECG diagnosis of left ventricular hypertrophy: The change of the paradigm.

Author

Bacharova, Ljuba, Chevalier, Philippe, Gorenek, Bulent, Jons, Christian, Li, Yi‐Gang, Locati, Emanuela T., Maanja, Maren, Pérez‐Riera, Andrés Ricardo, Platonov, Pyotr G., Ribeiro, Antonio Luiz Pinho, Schocken, Douglas, Soliman, Elsayed Z., Svehlikova, Jana, Tereshchenko, Larisa G., Ugander, Martin, Varma, Niraj, Elena, Zaklyazminskaya, and Ikeda, Takanori

Abstract

The ECG diagnosis of LVH is predominantly based on the QRS voltage criteria. The classical paradigm postulates that the increased left ventricular mass generates a stronger electrical field, increasing the leftward and posterior QRS forces, reflected in the augmented QRS amplitude. However, the low sensitivity of voltage criteria has been repeatedly documented. We discuss possible reasons for this shortcoming and proposal of a new paradigm. The theoretical background for voltage measured at the body surface is defined by the solid angle theorem, which relates the measured voltage to spatial and non‐spatial determinants. The spatial determinants are represented by the extent of the activation front and the distance of the recording electrodes. The non‐spatial determinants comprise electrical characteristics of the myocardium, which are comparatively neglected in the interpretation of the QRS patterns. Various clinical conditions are associated with LVH. These conditions produce considerable diversity of electrical properties alterations thereby modifying the resultant QRS patterns. The spectrum of QRS patterns observed in LVH patients is quite broad, including also left axis deviation, left anterior fascicular block, incomplete and complete left bundle branch blocks, Q waves, and fragmented QRS. Importantly, the QRS complex can be within normal limits. The new paradigm stresses the electrophysiological background in interpreting QRS changes, i.e., the effect of the non‐spatial determinants. This postulates that the role of ECG is not to estimate LV size in LVH, but to understand and decode the underlying electrical processes, which are crucial in relation to cardiovascular risk assessment. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

Author

Lahrouchi, Najim, Tadros, Rafik, Crotti, Lia, Mizusawa, Yuka, Postema, Pieter G., Beekman, Leander, Walsh, Roddy, Hasegawa, Kanae, Barc, Julien, Ernsting, Marko, Turkowski, Kari L., Mazzanti, Andrea, Beckmann, Britt M., Shimamoto, Keiko, Diamant, Ulla-Britt, Wijeyeratne, Yanushi D., Kucho, Yu, Robyns, Tomas, Ishikawa, Taisuke, Arbelo, Elena, Christiansen, Michael, Winbo, Annika, Jabbari, Reza, Lubitz, Steven A., Steinfurt, Johannes, Rudic, Boris, Loeys, Bart, Shoemaker, M. Ben, Weeke, Peter E., Pfeiffer, Ryan, Davies, Brianna, Andorin, Antoine, Hofman, Nynke, Dagradi, Federica, Pedrazzini, Matteo, Tester, David J., Bos, J. Martijn, Sarquella-Brugada, Georgia, Campuzano, Óscar, Platonov, Pyotr G., Stallmeyer, Birgit, Zumhagen, Sven, Nannenberg, Eline A., Veldink, Jan H., van den Berg, Leonard H., Al-Chalabi, Ammar, Shaw, Christopher E., Shaw, Pamela J., Morrison, Karen E., Andersen, Peter M., Müller-Nurasyid, Martina, Cusi, Daniele, Barlassina, Cristina, Galan, Pilar, Lathrop, Mark, Munter, Markus, Werge, Thomas, Ribasés, Marta, Aung, Tin, Khor, Chiea C., Ozaki, Mineo, Lichtner, Peter, Meitinger, Thomas, van Tintelen, J. Peter, Hoedemaekers, Yvonne, Denjoy, Isabelle, Leenhardt, Antoine, Napolitano, Carlo, Shimizu, Wataru, Schott, Jean-Jacques, Gourraud, Jean-Baptiste, Makiyama, Takeru, Ohno, Seiko, Itoh, Hideki, Krahn, Andrew D., Antzelevitch, Charles, Roden, Dan M., Saenen, Johan, Borggrefe, Martin, Odening, Katja E., Ellinor, Patrick T., Tfelt-Hansen, Jacob, Skinner, Jonathan R., van den Berg, Maarten P., Olesen, Morten Salling, Brugada, Josep, Brugada, Ramón, Makita, Naomasa, Breckpot, Jeroen, Yoshinaga, Masao, Behr, Elijah R., Rydberg, Annika, Aiba, Takeshi, Kääb, Stefan, Priori, Silvia G., Guicheney, Pascale, Tan, Hanno L., Newton-Cheh, Christopher, Ackerman, Michael J., Schwartz, Peter J., Schulze-Bahr, Eric, Probst, Vincent, Horie, Minoru, Wilde, Arthur A., Tanck, Michael W.T., and Bezzina, Connie R.

Published
2020
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39. Left and Right Atrial Contribution to the P-wave in Realistic Computational Models

Author

Loewe, Axel, Krueger, Martin W., Platonov, Pyotr G., Holmqvist, Fredrik, Dössel, Olaf, Seemann, Gunnar, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, van Assen, Hans, editor, Bovendeerd, Peter, editor, and Delhaas, Tammo, editor

Published
2015
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40. MP-453089-11 DIFFERENCES IN UTILIZATION OF PRIMARY PREVENTION IMPLANTABLE CARDIOVERTER DEFIBRILLATORS IN ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ACROSS NORTH AMERICA AND EUROPE

Author

Carrick, Richard, primary, De Marco, Corrado, additional, Gasperetti, Alessio, additional, Bosman, Laurens P., additional, GOURRAUD, JEAN BAPTISTE, additional, Mazzanti, Andrea, additional, Murray, Brittney A., additional, Pendleton, Catherine, additional, Tichnell, Crystal, additional, Tandri, Harikrishna, additional, Zeppenfeld, Katja, additional, Wilde, Arthur A., additional, Davies, Brianna, additional, Seifer, Colette M., additional, Roberts, Jason D., additional, Healey, Jeffrey S., additional, MacIntyre, Ciorsti, additional, Alqarawi, Wael, additional, Tadros, Rafik, additional, Cutler, Michael J., additional, Targetti, Mattia, additional, Caló, Leonardo, additional, Vitali, Francesco, additional, Bertini, Matteo, additional, Compagnucci, Paolo, additional, Casella, Michela, additional, Russo, Antonio Dello, additional, Cappelletto, Chiara, additional, De Luca, Antonio, additional, Stolfo, Davide, additional, Duru, Firat, additional, Jensen, Henrik K., additional, Svensson, Anneli, additional, Dahlberg, Pia, additional, Hasselberg, Nina, additional, Di Marco, Andrea, additional, Jorda, Paloma, additional, Arbelo, Elena, additional, Moreno weidmann, Zoraida, additional, Borowiec, Karolina, additional, Deliniere, Antoine, additional, Biernacka, Elzbieta K., additional, van Tintelen, Peter, additional, Platonov, Pyotr G., additional, Olivotto, Iacopo, additional, Saguner, Ardan, additional, Haugaa, Kristina H., additional, Cox, Moniek, additional, Tondo, Claudio, additional, Merlo, Marco, additional, Krahn, Andrew D., additional, Riele, Anneline te, additional, Wu, Katherine C., additional, Calkins, Hugh, additional, James, Cynthia A., additional, and CADRIN-TOURIGNY, JULIA, additional

Published
2023
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43. PO-05-135 SIGNAL-AVERAGED ECG IN THE NORDIC ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY REGISTRY: ASSOCIATION WITH PREVALENT LIFE-THREATENING ARRHYTHMIAS AND ASCERTAINMENT OF CLINICAL DIAGNOSIS.

Author

Savelev, Aleksei, primary, Ulfarsson, Aevar, additional, Haugaa, Kristina H., additional, Svensson, Anneli, additional, Jensen, Henrik K., additional, Dahlberg, Pia, additional, Christensen, Alex, additional, Madsen, Trine, additional, Bundgaard, Henning, additional, Heliö, Tiina, additional, Edvardsen, Thor, additional, Svendsen, Jesper H., additional, and Platonov, Pyotr G., additional

Published
2023
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44. PO-02-228 ASSOCIATION BETWEEN SIGNAL-AVERAGED ECG INDICES AND RV STRUCTURAL ABNORMALITIES IN PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY: INSIGHTS FROM NORDIC ARVC REGISTER

Author

Savelev, Aleksei, primary, Ulfarsson, Aevar, additional, Haugaa, Kristina H., additional, Svensson, Anneli, additional, Jensen, Henrik K., additional, Dahlberg, Pia, additional, Christensen, Alex, additional, Madsen, Trine, additional, Bundgaard, Henning, additional, Edvardsen, Thor, additional, Svendsen, Jesper H., additional, and Platonov, Pyotr G., additional

Published
2023
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