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6. Diagnostic performance of nasal cytology

Author

Ciofalo, Andrea, Cavaliere, Carlo, Incorvaia, Cristoforo, Plath, Michaela, Ridolo, Erminia, Pucciarini, Francesco, Altissimi, Giancarlo, Greco, Antonio, de Vincentiis, Marco, and Masieri, Simonetta

Published
2022
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9. Sonstige Therapieformen – Hämotherapie – Ernährung – apparativ – onkologisch – alternativ – perspektivisch

Author

Thiele, Thomas, Selleng, Kathleen, Ranft, Andreas, Kochs, Eberhard Friedrich, Waldfahrer, Frank, Leuwer, Rudolf, Klein, Martin, Appold, Steffen, Folprecht, Gunnar, Schuler, Patrick, Dörr, Wolfgang, Dörr, Elke, Grötz, Knut A., Riesenbeck, Dorothea, Friese, Karl-Heinz, Plath, Michaela, Zaoui, Karim, and Reiß, Michael, editor

Published
2021
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18. Real-Life Evidence of Mepolizumab Treatment in Chronic Rhinosinusitis with Nasal Polyps: A Multicentric Study.

Author

Cavaliere, Carlo, Loperfido, Antonella, Ciofalo, Andrea, Di Michele, Loreta, Begvarfaj, Elona, Bellocchi, Gianluca, Bugani, Marcella, de Vincentiis, Marco, Greco, Antonio, Millarelli, Stefano, Plath, Michaela, Sculco, Eleonora, and Masieri, Simonetta

Subjects
SMELL disorders, NASAL polyps, SINUSITIS, EOSINOPHILS, BLOOD testing, DRUG administration, BASOPHILS
Abstract

Background: The introduction of biological drugs in the management of chronic rhinosinusitis with nasal polyps (CRSwNP) is allowing new and increasingly promising therapeutic options. This manuscript aims to provide a multicenter trial in a real-life setting on Mepolizumab treatment for severe uncontrolled CRSwNP with or without comorbid asthma. Methods: A retrospective data analysis was jointly conducted at the Otolaryngology–Head and Neck Surgery departments of La Sapienza University and San Camillo Forlanini Hospital in Rome. Both institutions participated by sharing clinical information on patients with CRSwNP treated with Mepolizumab. Patients were evaluated before starting Mepolizumab, at six months and at twelve months from the first drug administration. During follow–up visits, patients underwent endoscopic evaluation, quality of life assessment, nasal symptoms assessment, and blood tests to monitor mainly neutrophils, basophils, eosinophils, and IgG, IgA, and IgE assay. Results: Twenty patients affected by CRSwNP and treated with Mepolizumab were enrolled (12 females and 8 males with a mean age of 63.7 years). Sixteen patients (80%) had concomitant asthma. During follow-up, a gradual improvement in nasal polyp score, quality of life and nasal symptoms, assessed by SNOT-22 and VAS and loss of smell measured by olfactory VAS, was found. Regarding blood tests, eosinophils decreased gradually, while other blood parameters showed no statistically significant changes. Conclusions: Mepolizumab has been shown to be effective in the therapeutic management of patients with CRSwNP. Further studies are needed to support our findings and better understand the underlying immune pathways to predict patients' response to biological treatment in CRSwNP. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Quality of Life Improvement in Concurrent Septorhinoplasty and Endoscopic Sinus Surgery.

Author

Bulut, Olcay Cem, Lippert, Burkard M., Riedel, Frank, Plath, Michaela, and Hohenberger, Ralph

Abstract

Objectives: Septorhinoplasty (SRPL) and functional endoscopic sinus surgery (FESS) are two frequently performed surgeries to improve quality of life (QoL) in patients with nasal symptoms. It has been demonstrated as a safe combination regarding complication rates, but patient satisfaction in concurrent surgery has not been adequately studied yet. Methods: Patients undergoing sole FESS due to chronic rhinosinusitis (n = 57), sole SRPL (n = 148), and concurrent surgery (n = 62) were prospectively evaluated for their disease‐specific QoL before and one year after surgery. Each procedure was performed by the same surgeon (OCB). For SRPL, the patient‐reported outcome measures Rhinoplasty Outcomes Evaluation (ROE) and Functional Rhinoplasty Outcome Inventory (FROI‐17) were utilized, and for chronic rhinosinusitis, the Sino‐Nasal Outcome Test‐22 (SNOT22). Results: All three groups showed significant improvement in the postoperative QoL measurements (all p < 0.01). The postoperative improvements were slightly smaller in the concurrent surgery group compared with the single surgery groups measured with ROE (combined: +55.2 ± 9.3, single: +58.8 ± 9.8, p = 0.02), FROI total score (combined: +47.6 ± 5.2, single: +49 ± 5.4; p = 0.08) and SNOT22 (combined: +33.1 ± 6.7, single +34.5 ± 7, p = 0.26). Conclusions: SRPL, FESS, and combined surgery improve disease‐specific QoL. When applicable, surgeons may offer the benefits of a combined procedure without compromising the QoL gain. Level of Evidence: 3 Laryngoscope, 134:1239–1245, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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26. Serious Long-Term Effects of Head and Neck Cancer from the Survivors’ Point of View

Author

Taylor, Katherine J., Amdal, Cecilie, Bjordal, Kristin, Astrup, Guro, Herlofson, Bente, Duprez, Fréderic, Gama, Ricardo R., Jacinto, Alexandre, Hammerlid, Eva, Scricciolo, Melissa, Jansen, Femke, Verdonck-de Leeuw, Irma, Fanetti, Giuseppe, Guntinas-Lichius, Orlando, Inhestern, Johanna, Dragan, Tatiana, Fabian, Alexander, Boehm, Andreas, Wöhner, Ulrike, Kiyota, Naomi, Krüger, Maximilian, Bonomo, Pierluigi, Pinto, Monica, Nuyts, Sandra, Silva, Joaquim C., Stromberger, Carmen, Tramacere, Francesco, Bushnak, Ayman, Perotti, Pietro, Plath, Michaela, Paderno, Alberto, Stempler, Noa, Kouri, Maria, Singer, Susanne, Taylor, Katherine J., Amdal, Cecilie, Bjordal, Kristin, Astrup, Guro, Herlofson, Bente, Duprez, Fréderic, Gama, Ricardo R., Jacinto, Alexandre, Hammerlid, Eva, Scricciolo, Melissa, Jansen, Femke, Verdonck-de Leeuw, Irma, Fanetti, Giuseppe, Guntinas-Lichius, Orlando, Inhestern, Johanna, Dragan, Tatiana, Fabian, Alexander, Boehm, Andreas, Wöhner, Ulrike, Kiyota, Naomi, Krüger, Maximilian, Bonomo, Pierluigi, Pinto, Monica, Nuyts, Sandra, Silva, Joaquim C., Stromberger, Carmen, Tramacere, Francesco, Bushnak, Ayman, Perotti, Pietro, Plath, Michaela, Paderno, Alberto, Stempler, Noa, Kouri, Maria, and Singer, Susanne

Abstract

The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the long-term quality of life in this population, 1114 HNCS were asked to state their two most serious long-term effects. A clinician recorded the responses during face-to-face appointments. A list of 15 example problems was provided, but a free text field was also available. A total of 1033 survivors responded to the question. The most frequent problems were ‘dry mouth’ (DM) (n = 476; 46%), ‘difficulty swallowing/eating’ (DSE) (n = 408; 40%), ‘hoarseness/difficulty speaking’ (HDS) (n = 169; 16%), and ‘pain in the head and neck’ (PHN) (n = 142; 14%). A total of 5% reported no problems. Logistic regression adjusted for age, gender, treatment, and tumor stage and site showed increased odds of reporting DM and DSE for chemo-radiotherapy (CRT) alone compared to surgery alone (odds ratio (OR): 4.7, 95% confidence interval (CI): 2.5–9.0; OR: 2.1, CI: 1.1–3.9), but decreased odds for HDS and PHN (OR: 0.3, CI: 0.1–0.6; OR: 0.2, CI: 0.1–0.5). Survivors with UICC stage IV at diagnosis compared to stage I had increased odds of reporting HDS (OR: 1.9, CI: 1.2–3.0). Laryngeal cancer survivors had reduced odds compared to oropharynx cancer survivors of reporting DM (OR: 0.4, CI: 0.3–0.6) but increased odds of HDS (OR: 7.2, CI: 4.3–12.3). This study provides evidence of the serious long-term problems among HNCS., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

27. Supplemental Figure legends from Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer

Author

Feng, Bohai, primary, Shen, Ying, primary, Pastor Hostench, Xavier, primary, Bieg, Matthias, primary, Plath, Michaela, primary, Ishaque, Naveed, primary, Eils, Roland, primary, Freier, Kolja, primary, Weichert, Wilko, primary, Zaoui, Karim, primary, and Hess, Jochen, primary

Published
2023
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28. Supplementary Data S1 from Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer

Author

Feng, Bohai, primary, Shen, Ying, primary, Pastor Hostench, Xavier, primary, Bieg, Matthias, primary, Plath, Michaela, primary, Ishaque, Naveed, primary, Eils, Roland, primary, Freier, Kolja, primary, Weichert, Wilko, primary, Zaoui, Karim, primary, and Hess, Jochen, primary

Published
2023
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29. Supplemental Figues from Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer

Author

Feng, Bohai, primary, Shen, Ying, primary, Pastor Hostench, Xavier, primary, Bieg, Matthias, primary, Plath, Michaela, primary, Ishaque, Naveed, primary, Eils, Roland, primary, Freier, Kolja, primary, Weichert, Wilko, primary, Zaoui, Karim, primary, and Hess, Jochen, primary

Published
2023
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30. Supplemental Tables from Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer

Author

Feng, Bohai, primary, Shen, Ying, primary, Pastor Hostench, Xavier, primary, Bieg, Matthias, primary, Plath, Michaela, primary, Ishaque, Naveed, primary, Eils, Roland, primary, Freier, Kolja, primary, Weichert, Wilko, primary, Zaoui, Karim, primary, and Hess, Jochen, primary

Published
2023
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31. Serious Long-Term Effects of Head and Neck Cancer from the Survivors’ Point of View

Author

Taylor, Katherine J., primary, Amdal, Cecilie D., additional, Bjordal, Kristin, additional, Astrup, Guro L., additional, Herlofson, Bente B., additional, Duprez, Fréderic, additional, Gama, Ricardo R., additional, Jacinto, Alexandre, additional, Hammerlid, Eva, additional, Scricciolo, Melissa, additional, Jansen, Femke, additional, Verdonck-de Leeuw, Irma M., additional, Fanetti, Giuseppe, additional, Guntinas-Lichius, Orlando, additional, Inhestern, Johanna, additional, Dragan, Tatiana, additional, Fabian, Alexander, additional, Boehm, Andreas, additional, Wöhner, Ulrike, additional, Kiyota, Naomi, additional, Krüger, Maximilian, additional, Bonomo, Pierluigi, additional, Pinto, Monica, additional, Nuyts, Sandra, additional, Silva, Joaquim C., additional, Stromberger, Carmen, additional, Tramacere, Francesco, additional, Bushnak, Ayman, additional, Perotti, Pietro, additional, Plath, Michaela, additional, Paderno, Alberto, additional, Stempler, Noa, additional, Kouri, Maria, additional, and Singer, Susanne, additional

Published
2023
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36. Tumor Control and Quality of Life in Skin Cancer Patients With Extensive Multilayered Nasal Defects

Author

Plath, Michaela, Thielen, Hannah M., Baumann, Ingo, Zaoui, Karim, and Federspil, Philippe A.

Subjects
medicine.medical_specialty, Skin Neoplasms, medicine.medical_treatment, Nasal Surgical Procedures, lcsh:Medicine, Prosthesis, Rhinoplasty, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Surgical oncology, medicine, Basal cell carcinoma, 030212 general & internal medicine, 030223 otorhinolaryngology, Bone-Anchored Prosthesis, business.industry, lcsh:R, Retrospective cohort study, lcsh:Otorhinolaryngology, medicine.disease, lcsh:RF1-547, Surgery, Surgical Oncology, Otorhinolaryngology, Quality of Life, Original Article, Skin cancer, business
Abstract

Objectives. The reconstruction after nasal skin cancer (NSC) resection is often practiced differently. The objective of this study is to evaluate the influence of patient-, tumor- and management-related factors on the role of surgery and choice of reconstruction.Methods. This was a monocentric retrospective study of patients who were diagnosed with a NSC (squamous cell or basal cell carcinoma) and suffered from an extended defect after ablative surgery between 2003 and 2013. Twenty-five patients were included. Tumors were staged using the Union for International Cancer Control (eighth edition) TNM classification for primary cutaneous skin cancer of the head and neck. Preferred treatment was surgery in all patients. Health-related quality of life (HRQoL) measurement was evaluated by one generic (36-Item Short Form Health Survey [SF-36]) and two organ-specific questionnaires (Rhinoplasty Outcome Evaluation [ROE] and Functional Rhinoplasty Outcome Inventory 17 [FROI-17]) after therapy. Survival data were estimated by the Kaplan-Meier method and statistical analysis was performed by log-rank, analysis of variance, Levene’s and t-tests. The median follow-up time was 2.1 years.Results. According to the Union for International Cancer Control classification, 13 of 25 tumors were staged as pT1 (52%), four as pT2 (16%), seven as pT3 (28%) and one as pT4a (4%). Seventy-two percent of patients (n=18) chose plastic reconstruction, and for the remaining 28% (n=7) of the patients opted for an implant-retained prosthesis. The overall survival was 69.5% after 5 years, the 5-year recurrence-free survival was 90.9% and the 5-year disease-specific survival was 100%. There was no significant difference in the HRQoL outcome between both rehabilitation methods.Conclusion. Surgery in NSC gives an excellent oncologic prognosis. Nasal reconstruction and prostheses are both very viable options depending on tumor stage and biology, the patient’s wishes as well as the experience of the surgeon.

Published
2020
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40. Diagnostic performance of nasal cytology

Author

Ciofalo, Andrea, primary, Cavaliere, Carlo, additional, Incorvaia, Cristoforo, additional, Plath, Michaela, additional, Ridolo, Erminia, additional, Pucciarini, Francesco, additional, Altissimi, Giancarlo, additional, Greco, Antonio, additional, de Vincentiis, Marco, additional, and Masieri, Simonetta, additional

Published
2021
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45. Unraveling most abundant mutational signatures in head and neck cancer

Author

Plath, Michaela, primary, Gass, Johanna, additional, Hlevnjak, Mario, additional, Li, Qiaoli, additional, Feng, Bohai, additional, Hostench, Xavier Pastor, additional, Bieg, Matthias, additional, Schroeder, Lea, additional, Holzinger, Dana, additional, Zapatka, Marc, additional, Freier, Kolja, additional, Weichert, Wilko, additional, Hess, Jochen, additional, and Zaoui, Karim, additional

Published
2020
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48. Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer

Author

Feng, Bohai, primary, Shen, Ying, additional, Pastor Hostench, Xavier, additional, Bieg, Matthias, additional, Plath, Michaela, additional, Ishaque, Naveed, additional, Eils, Roland, additional, Freier, Kolja, additional, Weichert, Wilko, additional, Zaoui, Karim, additional, and Hess, Jochen, additional

Published
2020
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49. Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer

Author

Schmitt, Katrin, Molfenter, Britta, Laureano, Natalia Koerich, Tawk, Bouchra, Bieg, Matthias, Hostench, Xavier Pastor, Weichenhan, Dieter, Ullrich, Nina D., Shang, Viny, Richter, Daniela, Stoegbauer, Fabian, Schroeder, Lea, de Bem Prunes, Bianca, Visioli, Fernanda, Rados, Pantelis Varvaki, Jou, Adriana, Plath, Michaela, Federspil, Philippe A., Thierauf, Julia, Doescher, Johannes, Weissinger, Stephanie E., Hoffmann, Thomas K., Wagner, Steffen, Wittekindt, Claus, Ishaque, Naveed, Eils, Roland, Klussmann, Jens P., Holzinger, Dana, Plass, Christoph, Abdollahi, Amir, Freier, Kolja, Weichert, Wilko, Zaoui, Karim, Hess, Jochen, Schmitt, Katrin, Molfenter, Britta, Laureano, Natalia Koerich, Tawk, Bouchra, Bieg, Matthias, Hostench, Xavier Pastor, Weichenhan, Dieter, Ullrich, Nina D., Shang, Viny, Richter, Daniela, Stoegbauer, Fabian, Schroeder, Lea, de Bem Prunes, Bianca, Visioli, Fernanda, Rados, Pantelis Varvaki, Jou, Adriana, Plath, Michaela, Federspil, Philippe A., Thierauf, Julia, Doescher, Johannes, Weissinger, Stephanie E., Hoffmann, Thomas K., Wagner, Steffen, Wittekindt, Claus, Ishaque, Naveed, Eils, Roland, Klussmann, Jens P., Holzinger, Dana, Plass, Christoph, Abdollahi, Amir, Freier, Kolja, Weichert, Wilko, Zaoui, Karim, and Hess, Jochen

Abstract

Genomic sequencing projects unraveled the mutational landscape of head and neck squamous cell carcinoma (HNSCC) and provided a comprehensive catalog of somatic mutations. However, the limited number of significant cancer-related genes obtained so far only partially explains the biological complexity of HNSCC and hampers the development of novel diagnostic biomarkers and therapeutic targets. We pursued a multiscale omics approach based on whole-exome sequencing, global DNA methylation and gene expression profiling data derived from tumor samples of the HIPO-HNC cohort (n = 87), and confirmed new findings with datasets from The Cancer Genome Atlas (TCGA). Promoter methylation was confirmed by MassARRAY analysis and protein expression was assessed by immunohistochemistry and immunofluorescence staining. We discovered a set of cancer-related genes with frequent somatic mutations and high frequency of promoter methylation. This included the ryanodine receptor 2 (RYR2), which showed variable promoter methylation and expression in both tumor samples and cell lines. Immunohistochemical staining of tissue sections unraveled a gradual loss of RYR2 expression from normal mucosa via dysplastic lesion to invasive cancer and indicated that reduced RYR2 expression in adjacent tissue and precancerous lesions might serve as risk factor for unfavorable prognosis and upcoming malignant conversion. In summary, our data indicate that impaired RYR2 function by either somatic mutation or epigenetic silencing is a common event in HNSCC pathogenesis. Detection of RYR2 expression and/or promoter methylation might enable risk assessment for malignant conversion of dysplastic lesions.

Published
2019

50. Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer

Author

Schmitt, Katrin, primary, Molfenter, Britta, additional, Laureano, Natalia Koerich, additional, Tawk, Bouchra, additional, Bieg, Matthias, additional, Hostench, Xavier Pastor, additional, Weichenhan, Dieter, additional, Ullrich, Nina D., additional, Shang, Viny, additional, Richter, Daniela, additional, Stögbauer, Fabian, additional, Schroeder, Lea, additional, Bem Prunes, Bianca, additional, Visioli, Fernanda, additional, Rados, Pantelis Varvaki, additional, Jou, Adriana, additional, Plath, Michaela, additional, Federspil, Philippe A., additional, Thierauf, Julia, additional, Döscher, Johannes, additional, Weissinger, Stephanie E., additional, Hoffmann, Thomas K., additional, Wagner, Steffen, additional, Wittekindt, Claus, additional, Ishaque, Naveed, additional, Eils, Roland, additional, Klussmann, Jens P., additional, Holzinger, Dana, additional, Plass, Christoph, additional, Abdollahi, Amir, additional, Freier, Kolja, additional, Weichert, Wilko, additional, Zaoui, Karim, additional, and Hess, Jochen, additional

Published
2019
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