520 results on '"Plasma triglyceride"'
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2. Inhibitory kinetics and mechanism of pentacyclic triterpenoid from endophytic Colletotrichum gigasporum against pancreatic lipase.
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Patil, Ravindra, Patil, Samadhan, Maheshwari, Vijay, and Patil, Mohini
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COLLETOTRICHUM , *LABORATORY rats , *TRITERPENOIDS , *BODY weight , *ORLISTAT , *LIPASE inhibitors - Abstract
The burden of obesity is increasing all over the world. Except for Orlistat, no effective anti-obesity drug is currently available. Therefore, a search for the new anti-obesity compound is need of time. This study demonstrates macromolecular interaction and inhibitory effect of pentacyclic triterpenoids (PTT) on pancreatic lipase (PL). In the present study PTTs from endophytic Colletotrichum gigasporum were found to show significant inhibitory activity against PL with IC 50 of 16.62 ± 1.43 μg/mL. The PTT isolated through bioassay-guided isolation showed a dose-dependent (R2 = 0.915) inhibition against porcine PL and the results were comparable with the standard (Orlistat). Based on inhibition kinetic data, the gradual increase in K m (app) with increasing PTT concentration indicated that the mode of interaction of PTT with PL was a competitive type, and it directly competed with the substrate (p NPB) for the active site of PL. In vivo studies in Wistar rats at the oral dose (100 mg/kg body weight) of PTT significantly decreased (p < 0.05) incremental plasma triglyceride levels as compared to group B and TG absorption was down-regulated up to 49.18% vis a vis group D animals. The isolated PTT was identified as lupeol based on chromatographic and spectral data. The endophytic isolate was identified as Colletotrichum gigasporum based on morphology and ITS gene sequencing. The present study indicated that PTT had the potential to be used as a natural PL inhibitor in the treatment of obesity and the isolated endophyte can be a valuable bioresource for it. [ABSTRACT FROM AUTHOR]
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- 2021
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3. Corrigendum: Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.
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Chatree S, Sitticharoon C, Maikaew P, Pongwattanapakin K, Keadkraichaiwat I, Churintaraphan M, Sripong C, Sririwichitchai R, and Tapechum S
- Abstract
[This corrects the article DOI: 10.1177/1535370220962708.]., (Copyright © 2024 Chatree, Sitticharoon, Maikaew, Pongwattanapakin, Keadkraichaiwat, Churintaraphan, Sripong, Sririwichitchai and Tapechum.)
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- 2024
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4. A higher glycemic response to oral glucose is associated with higher plasma apolipoprotein C3 independently of BMI in healthy twins.
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Bozzetto, Lutgarda, Berntzen, Bram J., Kaprio, Jaakko, Rissanen, Aila, Taskinen, Marja-Riitta, and Pietiläinen, Kirsi H.
- Abstract
Background and Aims: Plasma apolipoprotein C3 (ApoC3) is associated with higher plasma triglyceride and type 2 diabetes incidence. We evaluated whether body mass index (BMI) or glucose metabolism were associated with ApoC3 in healthy monozygotic (MZ) twins.Methods and Results: Forty-seven MZ twin-pairs (20 man, 27 women), aged 23-42 years, were divided in subgroups according to discordance or concordance for (a) BMI (within-pair difference (Δ) in BMI≥3.0 or<3.0 kg/m2), or (b) 2-h glucose iAUC, during oral glucose tolerance test (ΔGlucose iAUC ≥97.5 or<97.5 mmol × 120 minutes). Within these discordant or concordant subgroups, we tested (Wilcoxon signed-rank test) co-twin differences in ApoC3, adiposity measures, insulin-resistance and beta-cell function indices, and plasma and lipoprotein lipids. In BMI-Discordant (p = 0.92) or BMI-Concordant (p = 0.99) subgroups, ApoC3 did not differ between leaner and heavier co-twins. In the Glucose-Discordant subgroup, ApoC3 was significantly higher in twins with higher Glucose iAUC than in their co-twins with the lower Glucose iAUC (10.03 ± 0.78 vs. 8.48 ± 0.52 mg/dl; M ± SE; p = 0.032). Co-twins with higher Glucose iAUC also had higher waist circumference, body fat percentage, liver fat content, worse insulin-sensitivity and beta-cell function and higher cholesterol and triglyceride in plasma VLDL, IDL, and LDL. In Glucose-Concordant twin-pairs, no significant differences were observed in the explored variables. In all twin-pairs, ΔApoC3 correlated with Δ in lipids and glucose metabolism variables, the closest relationship being between ΔApoC3 and ΔVLDL triglyceride (r = 0.74, p < 0.0001).Conclusions: While ApoC3 was not related to acquired differences in BMI, it associated with early dysregulation of glucose metabolism independently of obesity and genetic background. [ABSTRACT FROM AUTHOR]- Published
- 2020
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5. Diagnosis of the ApoB Dyslipoproteinemias: The ApoB Algorithm
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de Graaf, Jacqueline, Couture, Patrick, Sniderman, Allan D., de Graaf, Jacqueline, Couture, Patrick, and Sniderman, Allan D.
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- 2015
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6. Hyperlipidemia Influences the Accuracy of Glucometer-Measured Blood Glucose Concentrations in Genetically Diverse Mice
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Weibin Shi, Jiang He, Lisa J. Shi, and Xiwei Tang
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Blood Glucose ,Male ,medicine.medical_specialty ,Hyperlipidemias ,030204 cardiovascular system & hematology ,Article ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Plasma triglyceride ,Internal medicine ,Diabetes mellitus ,Hyperlipidemia ,Western diet ,Animals ,Medicine ,030212 general & internal medicine ,Inverse correlation ,Lipoprotein cholesterol ,Mice, Knockout ,Mice, Inbred BALB C ,business.industry ,Genetic Variation ,General Medicine ,Chow diet ,medicine.disease ,Endocrinology ,Female ,business ,Blood Chemical Analysis ,Lipoprotein - Abstract
Background Glucometers are widely used in animal research due to simplicity and ease of utilization, but their accuracy in blood glucose assessment for hyperlipidemic mice is unknown. Methods Here, we compared blood glucose levels measured by a glucometer with plasma glucose levels measured by a standard enzymatic assay for 325 genetically diverse F2 mice derived from LP and BALB/c (BALB) Apoe−/− mice. Non-fasting glucose levels were measured before initiation of a Western diet and after 11 weeks on the diet. Results On chow diet, lab-measured plasma glucose levels were 279.5 ± 42.6 mg/dl (mean ± SD), while blood glucose values measured by glucometer were 138.7 ± 16.6 mg/dl. The two measures had no correlation (R2 = 0.006, p = 0.167). On the Western diet, plasma glucose levels rose to 351.1 ± 121.6 mg/dl, while glucometer-measured blood glucose fell to 128.7 ± 27.9 mg/dl. The two measures showed a moderate correlation (R2 = 0.111, p = 3.1E-9). Lab-measured plasma glucose showed strong positive correlations with plasma triglyceride and non-high-density lipoprotein cholesterol levels, while glucometer-measured blood glucose showed an inverse correlation with non-high-density lipoprotein levels on the chow diet. Conclusions Our results indicate that hyperlipidemia affects the accuracy of glucometers in measuring blood glucose levels of mice.
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- 2021
7. No effect of acute normobaric hypoxia on plasma triglyceride levels in fasting healthy men.
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Mahat, Bimit, Chassé, Étienne, Lindon, Clare, Mauger, Jean-François, and Imbeault, Pascal
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HYPOXEMIA , *CROSSOVER trials , *FASTING , *FATTY acids , *GENETIC disorders , *GLYCERIN , *HEALTH status indicators , *LIPID metabolism disorders , *TRIGLYCERIDES , *RANDOMIZED controlled trials - Abstract
Circulating fatty acids are a major systemic energy source in the fasting state as well as a determinant of hepatic triglycerides (TG)-rich very-low-density lipoprotein production. Upon acute hypoxia, sympathetic arousal induces adipose tissue lipolysis, resulting in an increase in circulating nonesterified fatty acids (NEFA). Animal studies suggest that TG clearance may also be strongly reduced under hypoxia, though this effect has been shown to be dependent on temperature. Whether the hypoxia-induced rise in blood fatty acid concentrations affects fasting TG levels in humans under thermoneutral conditions remains unknown. TG, NEFA, and glycerol levels were measured in fasted healthy young men ( n = 10) exposed for 6 h to either normoxia (ambient air) or acute hypoxia (fraction of inspired oxygen = 0.12) in a randomized, crossover design. Participants were casually clothed and rested in front of a fan in an environmental chamber maintained at 28 °C during each trial. Under hypoxia, a significantly greater increase in NEFA occurred (condition × time interaction, p = 0.049) and glycerol levels tended to be higher (condition × time, p = 0.104), suggesting an increase in adipose tissue lipolysis. However, plasma TG levels did not change over time and did not differ between the normoxia and hypoxia conditions. In conclusion, acute exposure to normobaric hypoxia under thermoneutral condition in healthy men during fasting state increased lipolysis without affecting circulating TG. [ABSTRACT FROM AUTHOR]
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- 2018
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8. Plasma triglycerides as a risk factor for chronic kidney disease in type 2 diabetes mellitus: Evidence from northeastern Thailand.
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Zaman, Sojib Bin, Karim, Mohd Anisul, Hossain, Naznin, Al Kibria, Gulam Muhammed, and Islam, Sheikh Mohammed Shariful
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PEOPLE with diabetes , *KIDNEY disease risk factors , *ANALYSIS of triglycerides , *GLYCEMIC control , *BLOOD plasma - Abstract
Aims: To investigate the observational association between plasma triglyceride and CKD in patients with T2DM.Methods: A hospital-based retrospective registry was used to obtain data of 3,748 T2DM patients from May 2016 to October 2016. Anthropometric measurements and biochemical reports of T2DM patients with CKD were obtained by data extraction of medical records. CKD was defined according to the estimated glomerular filtration rate (eGFR< 60 mL/min/1.73 m2). Multiple logistic regression was used to determine the association between plasma triglyceride and CKD.Results: The mean age of the participants was 61.4 ± 11.0 years, and a majority of them was female (64%) with poor glycemic control (83%), increased plasma triglyceride (51%) and 27% of T2DM patients had CKD. There was a significant trend towards deteriorating renal function (lower eGFR) with categorically raised triglyceride levels. After controlling for age, sex and other confounders, 'borderline high' (adjusted odds ratio (OR): 1.24, 95% confidence interval (CI): 1.01-1.54), 'high' (adjusted OR: 1.52, 95% CI: 1.24-1.85) and 'very high' (adjusted OR: 3.40, 95% CI: 1.94-5.94) triglyceride level groups had higher likelihood to have CKD compared to normal triglyceride level.Conclusion: CKD was associated with a higher level of plasma triglyceride among patients with T2DM. These results support the rationale to screen and manage increased triglyceride in routine clinical practices among persons with diabetes to prevent CKD. [ABSTRACT FROM AUTHOR]- Published
- 2018
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9. n-3 Fatty Acids from Fish and Plants : Primary and Secondary Prevention of Cardiovascular Disease
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Connor, Sonja L., Connor, William E., Bendich, Adrianne, editor, and Deckelbaum, Richard J., editor
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- 2005
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10. Plasma glycerol levels in men with hypertriglyceridemia
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Birgitte Brock and Janne Lebeck
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Glycerol ,Adult ,Male ,Glycerol kinase ,Clinical chemistry ,Clinical Biochemistry ,Glycerol/blood ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,Hydrolysis ,0302 clinical medicine ,Plasma triglyceride ,Spectrophotometry ,medicine ,Humans ,030212 general & internal medicine ,Triglycerides ,Hypertriglyceridemia ,Chromatography ,medicine.diagnostic_test ,General Medicine ,Plasma ,Middle Aged ,medicine.disease ,Hypertriglyceridemia/blood ,Triglycerides/blood ,chemistry - Abstract
When plasma triglyceride is assessed in standard laboratories, it is a measurement of plasma glycerol after hydrolysis of triglycerides into fatty acids and glycerol. In most patients, the plasma level of free glycerol will only marginally influence the measurement of plasma triglyceride. However, in rare cases elevated free glycerol concentrations causes pseudohypertriglyceridemia and blanking for free glycerol becomes important. In this study, we investigated the plasma free glycerol level in 100 adult men with mild to moderate hypertriglyceridemia to assess the need for providing a free glycerol measurement in our clinical biochemistry department. The plasma samples were obtained in our blood sampling facility that receives both in- and outpatients. The highest plasma level of free glycerol observed was 300 µmol/L and in 99% of the investigated men the inclusion of plasma free glycerol in the measurement of plasma triglyceride cause a less than 10% false increase in plasma triglyceride. A weak positive correlation between the plasma levels of free glycerol and triglyceride was observed. When subdividing the cohort into mild and moderate hypertriglyceridemia, the positive correlation was only maintained in the moderate hypertriglyceridemia group that also demonstrated a 23% higher plasma glycerol level than men with mild hypertriglyceridemia. We conclude that even though glycerol blanking is relevant in rare occasions, then this study does not support providing such a measurement in our department. The positive correlation between free glycerol and triglyceride in this cohort likely reflects a shared association with metabolic dysregulation.
- Published
- 2021
11. Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects
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Anna Surowska, Prasanthi Jegatheesan, Vanessa Campos, Anne-Sophie Marques, Léonie Egli, Jérémy Cros, Robin Rosset, Virgile Lecoultre, Roland Kreis, Chris Boesch, Bertrand Pouymayou, Philippe Schneiter, and Luc Tappy
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sucrose overfeeding ,hepatic steatosis ,intramyocellular lipids ,intrahepatocellular lipids ,dietary protein content ,dietary fat content ,energy expenditure ,plasma triglyceride ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Sucrose overfeeding increases intrahepatocellular (IHCL) and intramyocellular (IMCL) lipid concentrations in healthy subjects. We hypothesized that these effects would be modulated by diet protein/fat content. Twelve healthy men and women were studied on two occasions in a randomized, cross-over trial. On each occasion, they received a 3-day 12% protein weight maintenance diet (WM) followed by a 6-day hypercaloric high sucrose diet (150% energy requirements). On one occasion the hypercaloric diet contained 5% protein and 25% fat (low protein-high fat, LP-HF), on the other occasion it contained 20% protein and 10% fat (high protein-low fat, HP-LF). IHCL and IMCL concentrations (magnetic resonance spectroscopy) and energy expenditure (indirect calorimetry) were measured after WM, and again after HP-LF/LP-HF. IHCL increased from 25.0 ± 3.6 after WM to 147.1 ± 26.9 mmol/kg wet weight (ww) after LP-HF and from 30.3 ± 7.7 to 57.8 ± 14.8 after HP-LF (two-way ANOVA with interaction: p < 0.001 overfeeding x protein/fat content). IMCL increased from 7.1 ± 0.6 to 8.8 ± 0.7 mmol/kg ww after LP-HF and from 6.2 ± 0.6 to 6.9 ± 0.6 after HP-LF, (p < 0.002). These results indicate that liver and muscle fat deposition is enhanced when sucrose overfeeding is associated with a low protein, high fat diet compared to a high protein, low fat diet.
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- 2019
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12. n-3 Fatty Acids from Fish and Plants : Primary and Secondary Prevention of Cardiovascular Disease
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Connor, William E., Connor, Sonja L., Bendich, Adrianne, editor, and Deckelbaum, Richard J., editor
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- 2001
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13. Serum Triglycerides? Another Risk Factor
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Truswell, A. Stewart and Truswell, A. Stewart
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- 2010
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14. Lipoprotein Metabolism and Atherogenesis
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Shepherd, James, Packard, Christopher J., Kita, Toru, editor, and Yokode, Masayuki, editor
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- 2000
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15. Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes
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McKeigue, Paul M., Conn, P. Michael, editor, Reaven, Gerald M., editor, and Laws, Ami, editor
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- 1999
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16. Recent advances in the pathogenesis of hereditary fructose intolerance
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VARIANT ,Fructose ,URIC-ACID ,HUMAN ALDOLASE-B ,MOLECULAR ANALYSIS ,Hereditary fructose intolerance ,HEPATIC LIPOGENESIS ,PLASMA TRIGLYCERIDE ,Glucokinase regulatory protein ,REGULATORY PROTEIN ,Ketohexokinase ,De novo lipogenesis ,Non-alcoholic fatty liver disease ,METABOLIC SYNDROME ,FASTING GLUCOSE ,GLUCOKINASE - Abstract
Hereditary fructose intolerance (HFI) is a rare inborn disease characterized by a deficiency in aldolase B, which catalyzes the cleavage of fructose 1,6-bisphosphate and fructose 1-phosphate (Fru 1P) to triose molecules. In patients with HFI, ingestion of fructose results in accumulation of Fru 1P and depletion of ATP, which are believed to cause symptoms, such as nausea, vomiting, hypoglycemia, and liver and kidney failure. These sequelae can be prevented by a fructose-restricted diet. Recent studies in aldolase B-deficient mice and HFI patients have provided more insight into the pathogenesis of HFI, in particular the liver phenotype. Both aldolase B-deficient mice (fed a very low fructose diet) and HFI patients (treated with a fructose-restricted diet) displayed greater intrahepatic fat content when compared to controls. The liver phenotype in aldolase B-deficient mice was prevented by reduction in intrahepatic Fru 1P concentrations by crossing these mice with mice deficient for ketohexokinase, the enzyme that catalyzes the synthesis of Fru 1P. These new findings not only provide a potential novel treatment for HFI, but lend insight into the pathogenesis of fructose-induced non-alcoholic fatty liver disease (NAFLD), which has raised to epidemic proportions in Western society. This narrative review summarizes the most recent advances in the pathogenesis of HFI and discusses the implications for the understanding and treatment of fructose-induced NAFLD.
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- 2020
17. Prevalence of Diabetes Mellitus and Associated Factors in Addis Ababa Public Health Facilities, Addis Ababa, Ethiopia, 2016
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Addisu Tadesse Sahile and Getabalew Endazenew Bekele
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Pharmacology ,medicine.medical_specialty ,Younger age ,Descriptive statistics ,business.industry ,Public health ,Physical activity ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Logistic regression ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Plasma triglyceride ,Environmental health ,Diabetes mellitus ,Internal Medicine ,Medicine ,business ,Stepwise approach - Abstract
Introduction Diabetes mellitus is one of the most public health challenges of the twenty-first century. Globally, 382 million people had diabetes by the year 2013. Purpose The purpose of this study was to determine the prevalence of diabetes mellitus and identify its associated factors at public health institutions in Addis Ababa. Patients and Methods An institution-based cross-sectional study was carried out from June to July 2016. A total of 758 participants were selected using a multistage sampling technique. Data were collected with a structured interviewer-administered questionnaire; a WHO STEPwise approach of NCDs risk factors identification, and the collected data were checked for completeness immediately following data collection and the filled questionnaires were entered into Epi-Info 3.5.1, and then exported to SPSS 23 for further analysis. Descriptive statistics such as mean, percentages, standard deviation, and ranges were determined. To identify factors associated with diabetes mellitus, binary logistics regression was used. Results The overall prevalence of diabetes mellitus was 14.8%, with a sex-specific prevalence of 18.35% and 16.62% for males and females, respectively. Older age participants had higher risks of developing diabetes mellitus than younger age individuals. Alcohol drinkers had more risks of developing diabetes mellitus than non-alcohol drinkers. Participants with plasma HDL-C ≥40mg/dl were more likely to develop diabetes mellitus than those with
- Published
- 2020
18. Short‐term physiological role of thyroxine administration on plasma metabolites and growth performance of Sterlet sturgeon Acipenser ruthenus
- Author
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Bahram Falahatkar, Bahman Meknatkhah, Hamed Abdollahpour, and Iraj Efatpanah
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0303 health sciences ,food.ingredient ,biology ,Coconut oil ,04 agricultural and veterinary sciences ,Single injection ,Metabolism ,Aquatic Science ,biology.organism_classification ,03 medical and health sciences ,Sturgeon ,Animal science ,food ,Plasma triglyceride ,Thyroid hormones ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Acipenser ruthenus ,Metabolic profile ,030304 developmental biology - Abstract
Thyroid hormones (THs) play important roles in regulating growth, development and physiological functions in vertebrates. To study the role of short‐term effects of thyroxine (T4) on metabolism and growth in female Sterlet sturgeon, thirty fish with a weight of 707.97 ± 37.15 g were divided into six tanks. Fish were injected intraperitoneal with (a) coconut oil alone (control), (b) 1 mg T4 kg per BW in coconut oil (T₁) and (c) 10 mg T4 kg per BW in coconut oil (T₁₀). Blood samples were collected at 0, 4, 7, 14, 28 and 60 days for plasma biochemical analysis, and body length and mass were determined at day 60. Based on results, higher growth was indicated in T₁₀ group. The highest T4 levels were observed on day 4 in the T₁ and T₁₀ treatments and gradually declined during the trial. Plasma T3 levels were highest on days 4 and 7 in the T₁ and T₁₀ groups, respectively. Plasma triglyceride levels were significantly elevated on day 28 in the T₁ group and on day 60 in the T₁₀ group. Plasma glucose concentrations were significantly elevated on days 7 and 14 in T₁₀ group. Overall, the present results suggest that a single injection of T4 can improve growth via changes in the metabolic profile of Sterlet sturgeon.
- Published
- 2020
19. An adaptive test for meta‐analysis of rare variant association studies
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Wei Pan, Chong Wu, Junghi Kim, Peng Wei, Yiding Ma, and Tianzhong Yang
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Epidemiology ,Computer science ,Black People ,Locus (genetics) ,Coronary Artery Disease ,Machine learning ,computer.software_genre ,Rare variant association ,White People ,Article ,Statistical power ,03 medical and health sciences ,Meta-Analysis as Topic ,Plasma triglyceride ,Humans ,Exome ,Triglycerides ,Genetics (clinical) ,030304 developmental biology ,0303 health sciences ,Models, Genetic ,Genetic heterogeneity ,business.industry ,030305 genetics & heredity ,R package ,Phenotype ,Meta-analysis ,N-Acetylgalactosaminyltransferases ,Computerized adaptive testing ,Artificial intelligence ,business ,computer ,Genome-Wide Association Study - Abstract
Single genome-wide studies may be underpowered to detect trait-associated rare variants with moderate or weak effect sizes. As a viable alternative, meta-analysis is widely used to increase power by combining different studies. The power of meta-analysis critically depends on the underlying association patterns and heterogeneity levels, which are unknown and vary from locus to locus. However, existing methods mainly focus on one or only a few combinations of the association pattern and heterogeneity level, thus may lose power in many situations. To address this issue, we propose a general and unified framework by combining a class of tests including and beyond some existing ones, leading to high power across a wide range of scenarios. We demonstrate that the proposed test is more powerful than some existing methods in simulation studies, then show their performance with the NHLBI Exome-Sequencing Project (ESP) data. One gene (B4GALNT2) was found by our proposed test, but not by others, to be statistically significantly associated with plasma triglyceride. The signal was driven by African-ancestry subjects but it was previously reported to be associated with coronary artery disease among European-ancestry subjects. We implemented our method in an R package aSPUmeta, publicly available at https://github.com/ytzhong/metaRV and will be on CRAN soon.
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- 2019
20. Providing Comprehensive Dietary Fatty Acid Profiling from Saturates to Polyunsaturates with the Malaysia Lipid Study-Food Frequency Questionnaire: Validation Using the Triads Approach
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Khun-Aik Chuah, Zu-Wei Yeak, Kalyana Sundram, Menagah Ezhumalai, Karuthan Chinna, Choon-Heen Tan, and Tilakavati Karupaiah
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Adult ,Male ,0301 basic medicine ,dietary records ,food frequency questionnaire ,Population ,lcsh:TX341-641 ,Diet Surveys ,Diet Records ,comparative validity ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Plasma triglyceride ,Dietary Fatty Acid ,fatty acid composition ,Humans ,Medicine ,Obesity ,030212 general & internal medicine ,Food science ,education ,Aged ,chemistry.chemical_classification ,education.field_of_study ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Fatty Acids ,Malaysia ,Reproducibility of Results ,Food frequency questionnaire ,Fatty acid ,food and beverages ,biomarkers ,dietary assessment ,Feeding Behavior ,Nutrients ,Middle Aged ,Dietary Fats ,chemistry ,Female ,Fatty acid composition ,business ,lcsh:Nutrition. Foods and food supply ,Food Science ,Polyunsaturated fatty acid - Abstract
To address limited food frequency questionnaire (FFQ) capacity in public health monitoring in Malaysia, we aimed to develop a semi-quantitative FFQ for an adult multiethnic population for comprehensive fatty acid (FA) profiling inclusive of saturated (SFA), monounsaturated (MUFA), polyunsaturated fatty acids (PUFA), PUFA:SFA ratio, trans fatty acids, omega-3 and omega-6 FAs. A 240-food itemed FFQ used diet records (DR) of Malaysia Lipid Study (MLS) participants and fatty acid composition database from laboratory analyzed foods. The developed MLS-FFQ underwent face and content validation before relative validation in a free-living population (n = 114). Validation was facilitated for macronutrient data comparisons between DR and FFQ via Spearman&rsquo, s correlation coefficient analyses, and for fatty acid composition data by independent pairing of DR, FFQ and plasma triglyceride using the triads method. Moderate correlation between dietary methods was obtained for macronutrients and FAs (r = 0.225&ndash, 0.457, p <, 0.05) except for &omega, 3 FAs, presenting good agreement with grossly misclassified nutrients <, 10%. For fatty acid composition data, the magnitude of validity coefficients (z) for SFA, PUFA, PUFA:SFA ratios and &omega, 6 FAs by all 3 methods were not significantly different (p >, 0.05). In conclusion, the MLS-FFQ was shown to be a valid tool to assess population dietary intakes.
- Published
- 2021
21. Ficus thonningii Stem Bark Extracts Prevent High Fructose Diet Induced Increased Plasma Triglyceride Concentration, Hepatic Steatosis and Inflammation in Growing Sprague-Dawley Rats
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Eliton Chivandi, Trevor Nyakudya, Yvonne Mhosva, and Pilani Nkomozepi
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life_sciences_other ,Stem bark ,medicine.diagnostic_test ,biology ,Chemistry ,Inflammation ,Pharmacology ,medicine.disease ,biology.organism_classification ,Liver disease ,Plasma triglyceride ,medicine ,Sprague dawley rats ,Ficus thonningii ,medicine.symptom ,Steatosis ,Lipid profile - Abstract
BACKGROUND: Ficus thonningii extracts exhibit hypoglycaemic, hypolipidaemic and antioxidant activities. We investigated the potential of methanolic F. thonningii stem-bark extracts (MEFT) to protect growing Sprague-Dawley (SD) against high-fructose diet-induced metabolic derangements (MD) in a model mimicking children fed obesogenic diets. METHODS: Eighty (40 males; 40 females) 21-days old SD rat pups were randomly allocat-ed to and administered, for 8 weeks, five treatment regimens: 1 - standard rat chow (SC) + water (PW), 2 - SC + 20% (w/v) fructose solution (FS), 3 - SC + FS + fenofibrate at 100 mg/kg bwt/day, 4 - SC + FS + low dose MEFT (LD; 50 mg/kg bwt/day) and 5 - SC + FS + high dose MEFT (HD; 500 mg/kg bwt/day). Body weight, glucose load tolerance, fasting blood glucose and triglyceride, plasma insulin concentration, sensitivity to insulin, liver mass and fat content, steatosis and inflammation were determined. RESULTS: Fructose had no effect on the rats’ growth, glucose and insulin concentration, glucose tolerance and insulin sensitivity (P>0.05) but increased triglycerides in females; in-duced hepatic microsteatosis and inflammation in both sexes but macrosteatosis in females (P
- Published
- 2021
22. Mitochondrial Adaptive Responses to Hypertriglyceridemia and Bioactive Lipids
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Helena C. F. Oliveira and Luciane C. Alberici
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medicine.medical_specialty ,Physiology ,Clinical Biochemistry ,Cell Respiration ,Biochemistry ,Plasma triglyceride ,Internal medicine ,medicine ,Dietary Fatty Acid ,Humans ,skin and connective tissue diseases ,Molecular Biology ,General Environmental Science ,Hypertriglyceridemia ,business.industry ,Cell Biology ,Metabolism ,medicine.disease ,Lipids ,Mitochondria ,Endocrinology ,General Earth and Planetary Sciences ,sense organs ,business ,Energy Metabolism - Abstract
Significance: Altered plasma triglyceride metabolism and changes in dietary fatty acid types and levels are major contributors to the development of metabolic and cardiovascular diseases such as fa...
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- 2021
23. Atherogenicity of Triglyceride-Rich Lipoproteins: Clinical Aspects
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Caslake, Muriel, Gaw, Allan, Griffin, Bruce, Lindsay, Grace, Packard, Christopher, Shepherd, James, Catapano, A. L., editor, Gotto, A. M., Jr., editor, Smith, Louis C., editor, and Paoletti, Rodolfo, editor
- Published
- 1993
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24. Modulation of Triglyceride Metabolism by Diet and Drugs
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Pace, Patricia, Knapp, Roger D., Jones, Peter H., Pownall, Henry J., Gotto, Antonio M., Jr., Catapano, A. L., editor, Gotto, A. M., Jr., editor, Smith, Louis C., editor, and Paoletti, Rodolfo, editor
- Published
- 1993
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25. Common Mutations Underlying the Hypertriglyceridaemia/Low HDL Syndrome
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Galton, David J., Schettler, Gotthard, editor, Greten, Heiner, editor, and Habenicht, Andreas J. R., editor
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- 1993
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26. Plasma Triglyceride and Coronary Heart Disease
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Austin, Melissa A., Gotto, Antonio M., Jr., editor, Lenfant, Claude, editor, Paoletti, Rodolfo, editor, and Soma, Maurizio, editor
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- 1992
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27. Structure and Metabolism of Low Density Lipoproteins from Normal and Hypertriglyceridemic Subjects
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McKeone, Barry J., Patsch, Josef R., Pownall, Henry J., Malmendier, Claude L., editor, Alaupovic, P., editor, and Brewer, H. Bryan, Jr., editor
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- 1991
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28. Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4
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Hongfei Ge, Guoqing Yang, Xinxin Yu, Tiffany Pourbahrami, and Cai Li
- Subjects
lipoprotein lipase ,plasma triglyceride ,disulfide bond ,Biochemistry ,QD415-436 - Abstract
Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo. We recently reported that Angptl4 is a variable-sized oligomer formed by intermolecular disulfide bonds and undergoes regulated proteolytic processing upon secretion. We now show that adenoviral overexpression of Angptl4 potently increases plasma TG levels by a mechanism independent of food intake or hepatic VLDL secretion. We determined that cysteine residues at positions 76 and 80 of Angptl4, conserved among mouse, rat, and human, are required to form higher order structures. By generating adenoviral expression vectors of Angptl4 containing different epitope tags at both N and C termini, we show that loss of oligomerization results in decreased stability of the N-terminal coiled-coil domain of Angptl4 as well as decreased ability to increase plasma TG levels, suggesting that intermolecular disulfide bond formation plays important roles in determining the magnitude of the hyperlipidemic effect of Angptl4.Because Angptl4 is more potent than Angptl3 in increasing plasma TG levels in mice, inappropriate oligomerization of Angptl4 could be associated with disorders of lipid metabolism in vivo.
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- 2004
- Full Text
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29. Impact of race/ethnicity on insulin resistance and hypertriglyceridaemia
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Viraj Raygor, Erik Ingelsson, Joshua W. Knowles, Fahim Abbasi, Sun H. Kim, Laura C. Lazzeroni, and Gerald M. Reaven
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Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Race ethnicity ,Endocrinology, Diabetes and Metabolism ,Ethnic group ,Article ,California ,White People ,chemistry.chemical_compound ,Race (biology) ,Insulin resistance ,Risk Factors ,Plasma triglyceride ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,Humans ,Insulin ,Medicine ,Triglycerides ,Hypertriglyceridemia ,Asian ,Triglyceride ,business.industry ,Insulin sensitivity ,Health Status Disparities ,Hispanic or Latino ,Middle Aged ,medicine.disease ,Black or African American ,Cross-Sectional Studies ,Endocrinology ,chemistry ,Female ,Insulin Resistance ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Objective: Insulin sensitivity affects plasma triglyceride concentration and both differ by race/ethnicity. The purpose of this study was to provide a comprehensive assessment of the variation in insulin sensitivity and its relationship to hypertriglyceridaemia between five race/ethnic groups. Research design and methods: In this cross-sectional study, clinical data for 1025 healthy non-Hispanic White, Hispanic White, East Asian, South Asian and African American individuals were analysed. Insulin-mediated glucose disposal (a direct measure of peripheral insulin sensitivity) was measured using the modified insulin suppression test. Statistical analysis was performed using analysis of co-variance. Results: Of the study participants, 63% were non-Hispanic White, 9% were Hispanic White, 11% were East Asian, 11% were South Asian and 6% were African American. Overall, non-Hispanic Whites and African Americans displayed greater insulin sensitivity than East Asians and South Asians. Triglyceride concentration was positively associated with insulin resistance in all groups, including African Americans. Nevertheless, for any given level of insulin sensitivity, African Americans had the lowest triglyceride concentrations. Conclusion: Insulin sensitivity, as assessed by a direct measure of insulin-mediated glucose disposal, and its relationship to triglyceride concentration vary across five race/ethnic groups. Understanding these relationships is crucial for accurate cardiovascular risk stratification and prevention.
- Published
- 2019
30. Plasma triglyceride levels and central obesity predict the development of kidney injury in Chinese community older adults
- Author
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Yang Li, Lele Wang, Guangshan Sun, Xiaojie Zhou, Yujie Cao, Sha Zhang, Qian Zhang, Ruping Chen, Rui Liu, Xiangli Chao, and Ao Sun
- Subjects
Male ,elderly population ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,glomerular filtration rate (gfr) ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Chinese community ,chronic kidney disease (ckd) ,Incidence ,Age Factors ,General Medicine ,Middle Aged ,humanities ,Nephrology ,Creatinine ,Obesity, Abdominal ,Disease Progression ,kidney injury ,Female ,Independent Living ,Waist Circumference ,Glomerular Filtration Rate ,medicine.medical_specialty ,China ,03 medical and health sciences ,Plasma triglyceride ,Internal medicine ,Kidney injury ,medicine ,Humans ,triglyceride ,Renal Insufficiency, Chronic ,Triglycerides ,Aged ,Retrospective Studies ,Triglyceride ,central obesity ,business.industry ,Retrospective cohort study ,medicine.disease ,Obesity ,Diseases of the genitourinary system. Urology ,Blood pressure ,chemistry ,Clinical Study ,Observational study ,RC870-923 ,business ,Follow-Up Studies - Abstract
Objective: Despite the achievement of blood glucose, blood pressure targets, the risk for kidney injury remains high among older adults. This observational retrospective study investigated whether high TG or high WC contribute to this high residual risk for kidney injury. Methods: A total of 843 elderly from Dongli Community, Tianjin, China, we selected 666 individuals with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and negative microalbuminuria completing a 3-year follow-up. At baseline, subjects were grouped according to the levels of TG and WC. The primary outcome was the incidence of kidney injury, defined as low eGFR (eGFR 25%) or UACR ≥30 mg/g. Results: Overall, 6.01% developed low eGFR, 11.11% reduced eGFR, 25.98% UACR ≥30 mg/g, and 3.45% low eGFR and UACR ≥30mg/g after 3-year follow-up. TG ≥1.7 mmol/L increased the risk of eGFR
- Published
- 2019
31. Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice
- Author
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Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, and Brandon S.J. Davies
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Normal diet ,Science ,Adipose tissue ,030204 cardiovascular system & hematology ,Diet, High-Fat ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Plasma triglyceride ,ANGPTL4 ,Internal medicine ,Adipocyte ,medicine ,Glucose homeostasis ,Angiopoietin-Like Protein 4 ,Animals ,Triglycerides ,Mice, Knockout ,Lipoprotein lipase ,Mice, Inbred ICR ,Multidisciplinary ,Triglyceride ,Metabolic diseases ,030104 developmental biology ,Endocrinology ,Glucose ,chemistry ,Adipose Tissue ,Medicine ,Female ,Fat metabolism - Abstract
Elevated plasma triglyceride levels are associated with metabolic disease. Angiopoietin-like protein 4 (ANGPTL4) regulates plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). Our aim was to investigate the role of adipocyte-specific deficiency of ANGPTL4 in mice during high fat diet feeding. Adipocyte-specific ANGPTL4 deficient mice were fed a high fat diet (60% kCal from fat) for either 12 weeks or 6 months. We performed plasma metabolic measurements, triglyceride clearance and uptake assays, LPL activity assays, and assessed glucose homeostasis. Mice lacking adipocyte ANGPTL4 recapitulated the triglyceride phenotypes of whole-body ANGPTL4 deficiency, including increased adipose LPL activity, lower plasma triglyceride levels, and increased uptake of triglycerides into adipose tissue. When fed a high fat diet (HFD), these mice continued to display enhanced adipose LPL activity and initially had improved glucose and insulin sensitivity. However, after 6 months on HFD, the improvements in glucose homeostasis were largely lost. Moreover, despite higher adipose LPL activity levels, mice lacking adipocyte ANGPTL4 no longer had increased triglyceride uptake into adipose compared to littermate controls after chronic high-fat feeding. These observations suggest that after chronic high-fat feeding LPL is no longer rate-limiting for triglyceride delivery to adipocytes. We conclude that while adipocyte-derived ANGPTL4 is an important regulator of plasma triglyceride levels and triglyceride partitioning under normal diet conditions, its role is diminished after chronic high-fat feeding.
- Published
- 2021
32. Strawberry milky-white blood donor's plasma: signaling uncontrolled diabetic lipemia
- Author
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Anjali Ahlawat, Aditya Sahrawat, Manish Raturi, Mansi Kala, and Anuradha Kusum
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Blood Glucose ,medicine.medical_specialty ,medicine.medical_treatment ,Clinical Biochemistry ,Blood Donors ,Hyperlipidemias ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Plasma triglyceride ,Internal medicine ,Diabetes Mellitus ,Medicine ,Fatty meal ,Humans ,Poorly controlled diabetes mellitus ,Dietary fat ,Glycemic ,business.industry ,Insulin ,Biochemistry (medical) ,Venous Plasma ,Hematology ,Endocrinology ,Blood donor ,business ,030215 immunology - Abstract
Intake of a fatty meal before donating blood can lead to an increased level of plasma triglyceride concentration for several hours. This may cause either turbid and or “milky-white” appearance of their venous plasma samples. We, however, report a peculiar case about a male blood donor from India, whose plasma appeared to be “strawberry milky-white” in colour. On inquiry, he gave a history of poorly controlled diabetes mellitus type-II. Further, this was affirmed by his high blood glucose concentration [nearly 326 mg/dL] and HbA1c [13.7%] respectively. Moreover, his plasma triglyceride concentration was elevated up to 376 mg/dL. His treatment was started at our hospital and the strawberry colour of his plasma, dramatically recovered to normal straw-colour after achieving a fairly good glycemic control with the insulin therapy.
- Published
- 2021
33. Growth performance, nutrient digestibility, blood parameters, and carcass characteristics by lambs fed an oregano and cobalt blend
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C.L. Wang, R. Zhou, L.S. Liu, H.B. Liu, Liping Zhang, J.P. Wu, S. Wei, X. Lang, and D.P. Casper
- Subjects
Rump ,animal diseases ,Biology ,SF1-1100 ,Blood profiles ,chemistry.chemical_compound ,Animal science ,Frame growth ,Plasma triglyceride ,Origanum ,parasitic diseases ,Total serum protein ,Ruminal fermentation ,Animals ,Nutrient digestibility ,Sheep ,Cholesterol ,Immunity ,Cobalt ,Nutrients ,respiratory system ,Animal Feed ,Animal culture ,Diet ,chemistry ,Essential oils ,Animal Science and Zoology ,Digestion ,Average daily gain ,Blood parameters - Abstract
Shifting ruminal fermentation via feeding a blend of oregano (Organum vulgare L.) essential oils and Co-lactate (EOC; Rum-A-Fresh, Ralco, Inc. Marshall, MN) could improve lamb growth and carcass performance. Eighteen Suffolk × Little Han Tail F1 male lambs (20.3 ± 0.23 kg BW and approximately 3 months old) were randomly assigned using a completely random design to one of three treatments. Treatments were (1) EOC0: basal ration without EOC, (2) EOC4: basal ration plus 4 g/d EOC, and (3) EOC7: basal ration plus 7 g/d EOC. Initial and 24 d BW was similar (P > 0.10), but at 48 and 72 d, lambs fed EOC7 demonstrated greater (P = 0.01) BW compared with EOC0 fed lambs, while lambs fed EOC4 were intermediate and similar (P > 0.05). Average daily gains (ADGs) for 0–24 and 0–72 d were greater (P 0.10). Feed conversions for 0–24 d were improved (P 0.05). DM, NDF, and ADF digestibilities were similar (P > 0.10) among treatments, while CP digestibility was greater (P 0.01) for lambs fed EOC7 compared with lambs fed EOC0 and EOC4, while rump width was greater (P > 0.01) for lambs fed EOC4 and EOC7 compared with lambs fed EOC0. Plasma triglyceride and cholesterol concentrations were lower (P
- Published
- 2020
34. Sucrose – An Alternative Dietary Hypothesis
- Author
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Truswell, A. Stewart and Truswell, A. Stewart
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- 2010
- Full Text
- View/download PDF
35. Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects
- Author
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Kitchaya Pongwattanapakin, Sompol Tapechum, Rungnapa Sririwichitchai, Issarawan Keadkraichaiwat, Chantacha Sitticharoon, Saimai Chatree, Chanakarn Sripong, Malika Churintaraphan, and Pailin Maikaew
- Subjects
0301 basic medicine ,Adult ,Blood Glucose ,Leptin ,medicine.medical_specialty ,Lipolysis ,Adipocytes, White ,030209 endocrinology & metabolism ,Blood Pressure ,Epigallocatechin gallate ,Kidney ,complex mixtures ,General Biochemistry, Genetics and Molecular Biology ,Catechin ,Type ii diabetes ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Kisspeptin ,Plasma triglyceride ,Internal medicine ,medicine ,Humans ,heterocyclic compounds ,Obesity ,RNA, Messenger ,Triglycerides ,Uncoupling Protein 1 ,Original Research ,Kisspeptins ,business.industry ,food and beverages ,Middle Aged ,medicine.disease ,030104 developmental biology ,Endocrinology ,Blood pressure ,Adipocytes, Brown ,chemistry ,Liver ,sense organs ,Adiponectin ,business - Abstract
Obesity is one of major risk factors increasing chronic diseases including type II diabetes, cardiovascular diseases, and hypertension. The effects of epigallocatechin gallate (EGCG), the major active compound in green tea, on reduced obesity and improved metabolic profiles are still controversial. Furthermore, the effects of EGCG on human adipocyte lipolysis and browning of white adipocytes have not been elucidated. This study aimed to investigate the effects of EGCG on obesity, lipolysis, and browning of human white adipocytes. The results showed that, when compared to the baseline values, EGCG significantly decreased fasting plasma triglyceride levels ( P
- Published
- 2020
36. ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioning
- Author
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Brandon S.J. Davies, Emily M. Cushing, Kathryn M. Spitler, Shwetha K. Shetty, and Kelli L. Sylvers-Davie
- Subjects
medicine.medical_specialty ,Lipoprotein lipase ,Triglyceride ,Adipose tissue ,Phenotype ,chemistry.chemical_compound ,Endocrinology ,chemistry ,ANGPTL4 ,Plasma triglyceride ,Internal medicine ,Knockout mouse ,medicine ,Glucose homeostasis - Abstract
Elevated plasma triglyceride levels are associated with metabolic disease. Angiopoietin-like protein 4 (ANGPTL4) regulates plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). Our aim was to investigate the role of tissue-specific ANGPTL4 expression in the setting of high fat diet. Adipocyte- and hepatocyte-specific ANGPTL4 deficient mice were fed a high fat diet (60% kCal from fat) for either 12 weeks or 6 months. We performed plasma metabolic measurements, triglyceride clearance and uptake assays, LPL activity assays, and assessed glucose homeostasis. Mice lacking adipocyte ANGPTL4 recapitulated the triglyceride phenotypes of whole-body ANGPTL4 deficiency, whereas mice lacking hepatocyte ANGPTL4 had few triglyceride phenotypes. When fed a high fat diet (HFD), mice deficient in adipocyte ANGPTL4 gained more weight, had enhanced adipose LPL activity, and initially had improved glucose and insulin sensitivity. However, this improvement was largely lost after 6 months on HFD. Conversely, mice deficient in hepatocyte ANGPTL4 initially displayed no differences in glucose homeostasis, but began to manifest improved glucose tolerance after 6 months on HFD. We conclude that it is primarily adipocyte-derived ANGPTL4 that is responsible for regulating plasma triglyceride levels. Deficiency in adipocyte- or hepatocyte-derived ANGPTL4 may confer some protections against high fat diet induced dysregulation of glucose homeostasis.
- Published
- 2020
37. Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease
- Author
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Chao Han, Yueqiao Si, Wenjun Fan, Jingyi Liu, and Lixian Sun
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Lymphocyte ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Logistic regression ,Risk Assessment ,Asymptomatic ,Monocytes ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Plasma triglyceride ,Internal medicine ,medicine ,Humans ,Lymphocytes ,cardiovascular diseases ,030212 general & internal medicine ,Triglycerides ,Aged ,Retrospective Studies ,Subclinical infection ,business.industry ,Monocyte ,fungi ,General Medicine ,Middle Aged ,Atherosclerosis ,medicine.disease ,Cross-Sectional Studies ,medicine.anatomical_structure ,Cardiology ,Female ,medicine.symptom ,business ,Biomarkers ,Artery - Abstract
Background: The atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and monocyte-to-lymphocyte ratio (MLR) are strongly associated with atherogenesis of the coronary artery. This study aimed to investigate the association of the AIP, TyG index, and MLR with subclinical coronary artery disease (CAD) and evaluate their ability to predict subclinical CAD.Methods: A total of 697 asymptomatic patients were enrolled in this study and assigned to the subclinical CAD group (n=332) and control group (n=365). The clinical data, coronary artery calcification score, and calculated AIP, TyG index, and MLR were collected by graduate students in the cardiology division. Multivariate logistic regression models were set up to assess the risk factors for subclinical CAD.Results: The AIP, TyG index and MLR values were higher in the subclinical CAD group than in the control group (all PConclusions: The AIP, TyG index and MLR are independent risk factors for subclinical CAD, which can be useful for improving the diagnosis and prevention of CAD.
- Published
- 2020
38. Causes and Consequences of Hypertriglyceridemia
- Author
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Packard, Chris J., Boren, Jan, Taskinen, Marja-Riitta, HUS Heart and Lung Center, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, Research Programs Unit, and University of Helsinki
- Subjects
APOLIPOPROTEIN-B METABOLISM ,C-III ,chylomicron ,LOW-DENSITY-LIPOPROTEIN ,nutritional and metabolic diseases ,APO-B-100 KINETICS ,VLDL TRIGLYCERIDE ,POSTPRANDIAL HYPERTRIGLYCERIDEMIA ,lipid ,apoB ,PLASMA TRIGLYCERIDE ,3121 General medicine, internal medicine and other clinical medicine ,lipids (amino acids, peptides, and proteins) ,ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE ,FATTY-ACIDS ,metabolism ,VLDL ,TRIGLYCERIDE-RICH LIPOPROTEINS - Abstract
Elevations in plasma triglyceride are the result of overproduction and impaired clearance of triglyceride-rich lipoproteins-very low-density lipoproteins (VLDL) and chylomicrons. Hypertriglyceridemia is characterized by an accumulation in the circulation of large VLDL-VLDL1-and its lipolytic products, and throughout the VLDL-LDL delipidation cascade perturbations occur that give rise to increased concentrations of remnant lipoproteins and small, dense low-density lipoprotein (LDL). The elevated risk of atherosclerotic cardiovascular disease in hypertriglyceridemia is believed to result from the exposure of the artery wall to these aberrant lipoprotein species. Key regulators of the metabolism of triglyceride-rich lipoproteins have been identified and a number of these are targets for pharmacological intervention. However, a clear picture is yet to emerge as to how to relate triglyceride lowering to reduced risk of atherosclerosis.
- Published
- 2020
39. Deciphering the reasons for milky-white blood donor plasma
- Author
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Manish Raturi and Anuradha Kusum
- Subjects
medicine.medical_specialty ,Fatty foods ,Clinical Biochemistry ,Blood Donors ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Plasma triglyceride ,Internal medicine ,medicine ,Fatty meal ,Humans ,Serum triglycerides ,Dietary fat ,Triglycerides ,Plasma samples ,business.industry ,digestive, oral, and skin physiology ,Biochemistry (medical) ,Hematology ,Postprandial Period ,Lipids ,Blood donor ,Endocrinology ,business ,030215 immunology - Abstract
Donors who eat a fatty meal before donating blood are known to have an increased level of plasma triglyceride concentrations for several hours. This may contribute to "milky-white" appearance of their plasma samples. We herein report the case of a blood donor who gave a history of the intake of a fatty meal, on the night prior to donation. This was affirmed by his serum lipid concentration done on the following day and on repeating the same subsequently after two weeks of donation respectively.
- Published
- 2020
40. A higher glycemic response to oral glucose is associated with higher plasma apolipoprotein C3 independently of BMI in healthy twins
- Author
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Kirsi H. Pietiläinen, Marja-Riitta Taskinen, Aila Rissanen, Jaakko Kaprio, Bram J. Berntzen, Lutgarda Bozzetto, CAMM - Research Program for Clinical and Molecular Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Institute for Molecular Medicine Finland, Department of Public Health, HUS Abdominal Center, Department of Medicine, Clinicum, Endokrinologian yksikkö, Bozzetto, Lutgarda, Berntzen, Bram J., Kaprio, Jaakko, Rissanen, Aila, Marja-Riitta, Taskinen, and Pietiläinen, Kirsi H.
- Subjects
Blood Glucose ,Male ,Very low-density lipoprotein ,Time Factors ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Body fat percentage ,Body Mass Index ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,PLASMA TRIGLYCERIDE ,Finland ,Adiposity ,2. Zero hunger ,Glucose metabolism ,Nutrition and Dietetics ,Healthy Volunteers ,TWINS ,Female ,Apolipoprotein C3 ,Cardiology and Cardiovascular Medicine ,Twins ,Adult ,medicine.medical_specialty ,education ,030209 endocrinology & metabolism ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,Humans ,Obesity ,Triglycerides ,Glycemic ,Glucose Metabolism Disorders ,Apolipoprotein C-III ,Triglyceride ,business.industry ,Cholesterol ,Twins, Monozygotic ,Glucose Tolerance Test ,medicine.disease ,Endocrinology ,chemistry ,3121 General medicine, internal medicine and other clinical medicine ,business ,Body mass index ,Biomarkers - Abstract
Plasma apolipoprotein C3 (ApoC3) is associated with higher plasma triglyceride and type 2 diabetes incidence. We evaluated whether body mass index (BMI) or glucose metabolism were associated with ApoC3 in healthy monozygotic (MZ) twins. Forty-seven MZ twin-pairs (20 man, 27 women), aged 23-42 years, were divided in subgroups according to discordance or concordance for (a) BMI (within-pair difference (Δ) in BMI≥3.0 or
- Published
- 2020
41. ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico
- Author
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Zyanya Reyes-Castillo, Martha Nydia Ballesteros-Vásquez, Silvia Y. Moya-Camarena, Elizabeth Artalejo-Ochoa, Mildren Porchas-Quijada, Oney Román-Pellegrini, and Maricela Montalvo-Corral
- Subjects
Adult ,Blood Glucose ,Male ,Genotype ,Medicine (miscellaneous) ,Polymorphism, Single Nucleotide ,Young Adult ,Gene Frequency ,Plasma triglyceride ,Medicine ,Humans ,Insulin ,Paraoxonase-1 ,Mexico ,Triglycerides ,Metabolic Syndrome ,Hypertriglyceridemia ,Nutrition and Dietetics ,Polymorphism, Genetic ,business.industry ,Aryldialkylphosphatase ,Estudio transversal ,DNA ,rs2230808 polymorphism ,Allelic discrimination ,Middle Aged ,medicine.disease ,anti-oxLDL antibodies ,Molecular biology ,Lipids ,Mexican population ,R1587K ,Cross-Sectional Studies ,Cardiovascular diseases ,Heart Disease Risk Factors ,Body Composition ,Female ,lipids (amino acids, peptides, and proteins) ,Metabolic syndrome ,business ,ATP Binding Cassette Transporter 1 - Abstract
espanolIntroduccion: la proteina ABCA1 juega un papel principal en el transporte reverso del colesterol, promoviendo su eliminacion y la biogenesis de HDL. El polimorfismo de un solo nucleotido (SNP) R1587K (rs2230808) del gen ABCA1 se ha asociado con dislipidemias. Objetivo: investigar la relacion de los genotipos del SNP R1587K con el riesgo cardiovascular (CV), el sindrome metabolico (SM), el perfil de lipidos, la actividad de paraoxonasa 1 (PON1) y los anticuerpos contra las LDL oxidadas (anti-oxLDL). Metodos: se realizo un estudio transversal con 57 adultos del norte de Mexico que reportaron no tener enfermedades diagnosticadas. El SNP R1587K del gen ABCA1 se detecto a traves de PCR en tiempo real (qPCR) usando sondas TaqMan para discriminacion alelica. Para evaluar la asociacion del SNP R1587K con el SM y determinados parametros clinicos se determinaron el perfil de lipidos, los niveles de glucosa e insulina, la actividad y concentracion de PON1, los anticuerpos anti-oxLDL, los parametros antropometricos y de composicion corporal, y el calculo del indice aterogenico en plasma. Resultados: los resultados mostraron mayores niveles de trigliceridos en los portadores del genotipo RR + KK que en los portadores de RR (p = 0,031). Se observo una asociacion entre el genotipo RK + KK y la presencia de SM (OR = 4,566, IC 95% = 1,386-14,92, p = 0,010) y una tendencia hacia un mayor riesgo cardiovascular (OR = 3,317, IC 95% = 0,910-8,611, p = 0,069) al compararlos con los portadores de RR. No se encontraron diferencias en los niveles de HDL-C, la actividad y concentracion de PON1 y los anti-oxLDL entre los genotipos R1587K. Conclusiones: el SNP R1587K del gen ABCA1 se encuentra presente en la poblacion del norte de Mexico y el genotipo RK + KK se asocia con el SM y concentraciones elevadas de trigliceridos, por lo que este SNP podria ser un biomarcador de riesgo cardiovascular. Sin embargo, se necesita confirmacion a traves de estudios longitudinales. EnglishObjectives: to investigate the relationship of R1587K genotypes with cardiovascular (CV) risk, metabolic syndrome (MetS), lipid profile, paraoxonase-1 (PON1) activity, and anti-oxLDL titers. Methods: we performed a cross-sectional study in 57 northern Mexican adults with no reported diseases. The ABCA1 R1587K SNP was detected by real-time polymerase chain reaction (qPCR) using TaqMan allelic discrimination probes. We evaluated the relationship of R1587K with metabolic syndrome and clinical parameters including lipid profile, glucose and insulin, PON1 activity and concentration, anti-oxLDL antibodies, anthropometry and body-composition parameters, and the atherogenic index of plasma calculation. Results: our results show higher triglyceride levels in the RK + KK carriers as compared to RR carriers (p = 0.031). An association between the RK + KK genotype and the presence of MetS (OR = 4.566, 95% CI = 1.386-14.92, p = 0.010) and a tendency towards high CV risk (OR = 3.317, 95% CI = 0.910-8.611, p = 0.069) was observed in comparison to RR carriers; however, there were no differences in HDL-C levels, PON1 activity and concentration, and anti-oxLDL titers among the R1587K genotypes. Conclusions: in the northern Mexican population, the ABCA1 gene R1587K SNP is present and the RK + KK genotypes are associated with MetS and increased triglyceride concentrations; therefore, it could be a CV risk biomarker. Nevertheless there is a need for further confirmation in longitudinal studies.
- Published
- 2020
42. Biochemical Characterization of Pyramid Viper, Echis pyramidum, Venom.
- Author
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Al-Shammari, Ahmed M., Khan, Sami Ullah, Al-Sadoon, Mohammad Khalid, and Al-Saleh, Saad S. M.
- Abstract
This study was conducted to investigate the toxicological effects of Echis pyramidum crude venom and its purified protein fractions in male mice. The crude venom was fractionated and purified into eight fractions by 8% preparative native polyacrylamide gel electrophoresis. The mice were injected interaperitoneally with 50% of the lethal dose of crude venom and its purified fractions to keep 50% population of the injected animals alive to observe the different changes in the blood parameters. A significant increase was in plasma ALT level in animals injected with crude venom and fractions F1, F6 as compared to control group. A significant increase was in plasma AST level by crude venom and fraction F7. Glucose level increased significantly with crude venom whereas decreased significantly by fractions F4 and F5. There was up to 50% decrease in total plasma protein with crude venom and less than 50% decrease with fraction F7. Low plasma cholesterol levels were observed in group injected with crude venom and fraction F7. While fractions F2, F3 and F6 caused significant increase in plasma cholesterol level. Fraction F1 caused significant decrease in plasma triglyceride level whereas there was significant increase by crude venom. Blood urea level was significantly increased by crude venom fractions F2, F3 and F6. The significant increase in plasma creatinine level was produced by crude venom and fractions F1, F5, F7 and F8. Crude venom and fractions F1, F3, F5, F6 and F7 showed significant increase in uric acid level. The results of this study propose that E. pyramidum crude venom and its purified protein fractions exhibited potent toxic effects on some biochemical markers in male mice. [ABSTRACT FROM AUTHOR]
- Published
- 2013
43. Genome-wide linkage scan for loci influencing plasma triglyceride levels
- Author
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Nicholas B. Blackburn, Arthur Porto, Juan M. Peralta, John Blangero, and Jac Charlesworth
- Subjects
0301 basic medicine ,medicine.medical_specialty ,lcsh:Medicine ,Locus (genetics) ,Biology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,Genetic linkage ,Plasma triglyceride ,Internal medicine ,Genotype ,medicine ,lcsh:Science ,Genome wide linkage ,Fenofibrate ,Triglyceride ,lcsh:R ,Chromosome ,General Medicine ,Proceedings ,030104 developmental biology ,Endocrinology ,chemistry ,lcsh:Q ,medicine.drug - Abstract
We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-fenofibrate intervention. Multipoint identity-by-descent (MIBD) matrices were derived from genotypes using IBDLD. Variance-component linkage analyses were then conducted using SOLAR (Sequential Oligogenic Linkage Analysis Routines). We found evidence of linkage (logarithm of odds [LOD] ≥3) at 5 chromosomal regions with triglyceride levels in plasma. The highest LOD scores were observed for linkage to the estimated genetic value (additive genetic component) of the log-normalized triglyceride levels in plasma. Our results suggest that a chromosome 10 locus at 37 cM (LODpre = 3.01, LODpost = 3.72) influences fasting triglyceride levels in plasma regardless of the fenofibrate intervention, and that loci in chromosomes 1 at 170 cM and 4 at 24 cM ceases to affect the triglyceride levels when fenofibrate is present, while the regions in chromosomes 6 at 136 to 162 cM and 11 at 39 to 40 cM appear to influence triglyceride levels in response to fenofibrate.
- Published
- 2018
44. No effect of acute normobaric hypoxia on plasma triglyceride levels in fasting healthy men
- Author
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Jean-François Mauger, Étienne Chassé, Pascal Imbeault, Clare Lindon, and Bimit Mahat
- Subjects
Adult ,Blood Glucose ,Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Physiology ,Lipolysis ,Endocrinology, Diabetes and Metabolism ,Fatty Acids, Nonesterified ,Body Mass Index ,Young Adult ,03 medical and health sciences ,Absorptiometry, Photon ,Heart Rate ,Plasma triglyceride ,Physiology (medical) ,Internal medicine ,Humans ,Insulin ,Medicine ,Hypoxia ,Triglycerides ,Fasting state ,Adiposity ,A determinant ,Normobaric hypoxia ,Cross-Over Studies ,Nutrition and Dietetics ,business.industry ,Fasting ,General Medicine ,030104 developmental biology ,Endocrinology ,Oxyhemoglobins ,Body Composition ,business ,Energy source ,Lipoprotein - Abstract
Circulating fatty acids are a major systemic energy source in the fasting state as well as a determinant of hepatic triglycerides (TG)-rich very-low-density lipoprotein production. Upon acute hypoxia, sympathetic arousal induces adipose tissue lipolysis, resulting in an increase in circulating nonesterified fatty acids (NEFA). Animal studies suggest that TG clearance may also be strongly reduced under hypoxia, though this effect has been shown to be dependent on temperature. Whether the hypoxia-induced rise in blood fatty acid concentrations affects fasting TG levels in humans under thermoneutral conditions remains unknown. TG, NEFA, and glycerol levels were measured in fasted healthy young men (n = 10) exposed for 6 h to either normoxia (ambient air) or acute hypoxia (fraction of inspired oxygen = 0.12) in a randomized, crossover design. Participants were casually clothed and rested in front of a fan in an environmental chamber maintained at 28 °C during each trial. Under hypoxia, a significantly greater increase in NEFA occurred (condition × time interaction, p = 0.049) and glycerol levels tended to be higher (condition × time, p = 0.104), suggesting an increase in adipose tissue lipolysis. However, plasma TG levels did not change over time and did not differ between the normoxia and hypoxia conditions. In conclusion, acute exposure to normobaric hypoxia under thermoneutral condition in healthy men during fasting state increased lipolysis without affecting circulating TG.
- Published
- 2018
45. Effects of Fiber Purified Extract of Carob Fruit on Fat Digestion and Postprandial Lipemia in Healthy Rats
- Author
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A. Amores-Arrojo, Sara Bastida, María Elvira López-Oliva, Alba Garcimartín, F. Naes, Francisco J. Sánchez-Muniz, M. J. González-Muñoz, Juana Benedí, and Adrián Macho-González
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Hyperlipidemias ,030209 endocrinology & metabolism ,Absorption (skin) ,Fats ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,In vivo ,Plasma triglyceride ,Internal medicine ,medicine ,Animals ,Humans ,Pancreatic lipase ,Rats, Wistar ,Triglycerides ,030109 nutrition & dietetics ,biology ,Plant Extracts ,Cholesterol ,Fabaceae ,Lipase ,General Chemistry ,Postprandial Period ,Rats ,Postprandial ,Endocrinology ,chemistry ,Proanthocyanidin ,Fruit ,Maximum dose ,biology.protein ,General Agricultural and Biological Sciences - Abstract
Increased postprandial lipemia is a cardiovascular disease (CVD) risk factor. Carob fruit extract (CFE) contains condensed tannins, and their intake has been inversely related to CVD. The objective was to evaluate the in vitro pancreatic lipase activity in the presence of CFE and the in vivo effect of CFE on postprandial lipemia of healthy Wistar rats in acute and subchronic digestibility studies and to relate it with changes in fat digestion and absorption. CFE significantly reduced pancreatic lipase activity. A peak delay and a dose-dependent decrease in plasma triglyceride and cholesterol areas under the curve were observed, effects that increased after the subchronic treatment. The levels of nondigested, nonabsorbed triglycerides of the remaining intestinal lumen fat were significantly higher in the maximum dose of CFE administrated versus the control ( P0.05). This study demonstrates for the first time the hypolipemic properties of CFE from the first administration, modifying postprandial lipemia by reducing the extents of fat digestion and absorption.
- Published
- 2018
46. Triglyceride-Rich Lipoproteins
- Author
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Maaike Kockx and Leonard Kritharides
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Lipoproteins ,Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Plasma triglyceride ,Angiopoietin-like Protein ,Internal medicine ,Humans ,Medicine ,Lipoprotein metabolism ,Triglycerides ,Hypolipidemic Agents ,Hypertriglyceridemia ,Lipoprotein lipase ,Triglyceride ,business.industry ,General Medicine ,Lipid Metabolism ,030104 developmental biology ,Increased risk ,Endocrinology ,chemistry ,Cardiovascular Diseases ,Apolipoprotein CIII ,Cardiology and Cardiovascular Medicine ,business - Abstract
Plasma triglyceride levels are causally related to an increased risk of cardiovascular disease. Here, the authors summarize their understanding of triglyceride-rich lipoprotein metabolism, previous and newly identified regulators, and their relevance as candidate targets for therapeutic intervention.
- Published
- 2018
47. Effects of soybean lipid infusion on triglyceride and unbound free fatty acid levels in preterm infants
- Author
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Andrew Henry Huber, William Oh, Thomas Hegyi, Naureen Memon, Barry Weinberger, Mary Carayannopoulos, Alan M. Kleinfeld, and Weichung Joe Shih
- Subjects
Male ,0301 basic medicine ,Parenteral Nutrition ,medicine.medical_specialty ,Gestational Age ,Fatty Acids, Nonesterified ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Plasma triglyceride ,Intensive Care Units, Neonatal ,Internal medicine ,medicine ,Birth Weight ,Humans ,Phospholipids ,Triglycerides ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Triglyceride ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Fatty acid ,Bilirubin ,Lipid Metabolism ,Soybean Oil ,Endocrinology ,chemistry ,Pediatrics, Perinatology and Child Health ,Emulsions ,Female ,Soybeans ,Lipid infusion ,business ,Infant, Premature - Abstract
OBJECTIVE: To determine the plasma triglyceride (TG) and unbound free fatty acid (FFAu) levels in infants treated with increasing dosages of soybean lipid, intralipid (IL), infusion. STUDY DESIGN: TG and FFAu levels were measured in 78 preterm infants (BW 500–2000 g; GA 23–34 weeks) using the fluorescent probe ADIFAB2 and enzymatic method. RESULTS: The infants’ BW was 1266.2 ± 440.7 g and GA 28.8 ± 3.1 weeks. TG levels were 77.4 ± 50 mg/dL, 140.2 ± 188 mg/dL (p < .04 compared to levels during low dose IL infusion) and 135.6 ± 118 mg/dL (p < .004), respectively during increased IL rates. FFAu levels were 17.7 ± 13 nM, 47.3 ± 102.8 nM (p = .07) and 98 ± 234 nM (p = .03). TG levels correlated with IL dose, the rate of IL administration, and FFAu levels. TG and FFAu levels were higher in infants below 28 weeks’ gestation CONCLUSIONS: Increasing dosage of IL is associated with increasing levels of TG and FFAu, especially in infants below 29 weeks of gestation. The increased level of FFAu suggests inefficient cellular utilization.
- Published
- 2018
48. Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
- Author
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Kenichi Yoshida, Tetsuya Shimizugawa, Mitsuru Ono, and Hidehiko Furukawa
- Subjects
KK/San ,intravenous injection ,plasma triglyceride ,Biochemistry ,QD415-436 - Abstract
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein.Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro.
- Published
- 2002
- Full Text
- View/download PDF
49. Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration but not with visceral fat and liver fat content in people with type 1 diabetes
- Author
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Bruno Vergès, Thomas Gautier, Jean-Michel Petit, Benjamin Bouillet, Alexia Rouland, Laurent Lagrost, and Laurence Duvillard
- Subjects
medicine.medical_specialty ,Intra-Abdominal Fat ,Endocrinology, Diabetes and Metabolism ,Endocrinology ,Plasma triglyceride ,Internal medicine ,Diabetes mellitus ,Liver fat ,Internal Medicine ,medicine ,Humans ,Visceral fat ,Triglycerides ,Apolipoprotein C-I ,Type 1 diabetes ,business.industry ,General Medicine ,medicine.disease ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Liver ,Apolipoprotein C1 ,business - Published
- 2019
50. Plasma lipids relationship with results of Oral Glucose Challenge Test in pregnancy
- Author
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Soraya Salehi Gargari, Sedigheh Hantoushzadeh, Mina Jafarabadi, Sedigheh Borna, and Soghra Khazardoust
- Subjects
Oral Glucose Challenge Test ,Plasma Triglyceride ,Body Mass Index ,Gynecology and obstetrics ,RG1-991 - Abstract
Objective: This study aimed to evaluate the correlation between plasma lipid levels at first trimester of pregnancy and results of Oral Glucose Challenge Test (OGCT). Materials and methods: In a cross - sectional descriptive analytic study, two hundred eligible primigravida women without history of Diabetes Mellitus referring to Vali-e-Asr Hospital were evaluated. Plasma levels of triglyceride and cholesterol were measured at first trimester of pregnancy and Oral Glucose Challenge Test was done for all women at 24th - 28th gestational week. Pre-pregnancy BMI, and plasma levels of triglyceride and cholesterol at first trimester of pregnancy were compared with the results of OGCT. Results were analyzed using SPSS version 14. p-values ≤ 0.05 was considered statistically significant. Results: In 45 (22.5%) of the women OGCT was positive. Pre pregnancy BMI and the rate of positive result for OGCT were both correlated with the plasma levels of triglyceride and cholesterol at first trimester of pregnancy. Conclusion: Plasma lipid levels in first trimester can predict the result of OGCT at 24- 28 weeks of pregnancy.
- Published
- 2007
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