Search

Atypical spindle cell lipomatous tumour (ASCLT) is a benign neoplasm that presents a variable proportion of atypical spindle and adipocytic cells, frequently expressing CD34, and embedded in myxoid or collagenous matrix. An important feature is a constant lack of either MDM2 or CDK4 amplification. It typically arises in the extremities. The retroperitoneum is a rare site of involvement. We report a case of a retroperitoneal ASCLT in a 62-year-old male. A differential diagnosis of ASCLT from the other mesenchymal, spindle-cell, and lipomatous tumours is crucial for optimal treatment and significantly influences the prognosis. A diagnosis should be warranted by the immunohistochemistry and molecular findings.

Liposarcomas most often originate in the extremities and on the retroperitoneum. Primary malignant soft-tissue sarcoma of the chest is a rare entity. Most of them are low grade, and complete surgical excision is the preferred therapeutic choice. Like most cancers, the incidence of liposarcoma increases with advancing age, and subtotal resection is considered a palliative surgical procedure. The benefit of adjuvant radiotherapy or chemoradiotherapy for these tumors remains controversial.