177 results on '"Planinc, I"'
Search Results
2. Lower Platelet Count Following Induction with Antithymocyte Globulin is Associated with a Lower Incidence of Cardiac Allograft Vasculopathy
- Author
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Skoric, B., primary, Fabijanovic, D., additional, Mjehovic, P., additional, Nekic, A., additional, Jakus, N., additional, Planinc, I., additional, Pasalic, M., additional, Jurin, H., additional, Samardzic, J., additional, Cikes, M., additional, Gasparovic, H., additional, Colak, Z., additional, and Milicic, D., additional
- Published
- 2024
- Full Text
- View/download PDF
3. Intravenous angiotensin II as an add-on to standard of care vasopressors in patients with refractory shock on mechanical circulatory support: a single centre retrospective case series
- Author
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Sipus, D, primary, Momcilovic, M, additional, Percin, L, additional, Fabijanovic, D, additional, Pasara, V, additional, Jakus, N, additional, Planinc, I, additional, Pasalic, M, additional, Jurin, H, additional, Samardzic, J, additional, Skoric, B, additional, Cikes, M, additional, Milicic, D, additional, and Lovric, D, additional
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- 2024
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- View/download PDF
4. Predominance of a rare transthyretin mutation (p.Asp38Glu) in patients with hATTR cardiomyopathy: initial data from the Croatian Transthyretin Cardiac Amyloidosis Registry (CroATTR)
- Author
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Sipus, D, primary, Loncaric, F, additional, Jakus, N, additional, Fabijanovic, D, additional, Samardzic, J, additional, Skoric, B, additional, Mustapic, I, additional, Bakovic Kramaric, D, additional, Vinter, O, additional, Raljevic, D, additional, Ruzic, A, additional, Borovecki, F, additional, Milicic, D, additional, Cikes, M, additional, and Planinc, I, additional
- Published
- 2023
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- View/download PDF
5. Synchrotron-based X-ray phase contrast imaging of transmural cardiac tissue in patients treated for advanced heart failure
- Author
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Li, K Y C, primary, Loncaric, F, additional, Skreb, N, additional, Bonnin, A, additional, Dejea, H, additional, Garcia-Canadilla, P, additional, Ilic, I, additional, Gasparovic, H, additional, Milicic, D, additional, Bijnens, B, additional, Cook, A C, additional, Planinc, I, additional, and Cikes, M, additional
- Published
- 2023
- Full Text
- View/download PDF
6. Analytical solution of three-dimensional two-layer composite beam with interlayer slips
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Čas, B., Planinc, I., and Schnabl, S.
- Published
- 2018
- Full Text
- View/download PDF
7. Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial
- Author
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Cikes, M, Planinc, I, Claggett, B, Cunningham, J, Milicic, D, Sweitzer, N, Senni, M, Gori, M, Linssen, G, Shah, S, Packer, M, Pfeffer, M, Zile, M, Anand, I, Chiang, L, Lam, C, Redfield, M, Desai, A, Mcmurray, J, Solomon, S, Cikes M., Planinc I., Claggett B., Cunningham J., Milicic D., Sweitzer N., Senni M., Gori M., Linssen G., Shah S. J., Packer M., Pfeffer M., Zile M. R., Anand I., Chiang L. -M., Lam C. S. P., Redfield M., Desai A. S., McMurray J. J. V., Solomon S. D., Cikes, M, Planinc, I, Claggett, B, Cunningham, J, Milicic, D, Sweitzer, N, Senni, M, Gori, M, Linssen, G, Shah, S, Packer, M, Pfeffer, M, Zile, M, Anand, I, Chiang, L, Lam, C, Redfield, M, Desai, A, Mcmurray, J, Solomon, S, Cikes M., Planinc I., Claggett B., Cunningham J., Milicic D., Sweitzer N., Senni M., Gori M., Linssen G., Shah S. J., Packer M., Pfeffer M., Zile M. R., Anand I., Chiang L. -M., Lam C. S. P., Redfield M., Desai A. S., McMurray J. J. V., and Solomon S. D.
- Abstract
Objectives: In this study, the authors sought to assess the relationship between AFF and outcomes, the treatment response to sacubitril/valsartan and first-detected AFF in patients with HFpEF enrolled in the PARAGON-HF trial. Background: Atrial fibrillation and flutter (AFF) are common in heart failure with preserved ejection fraction (HFpEF) and increase the risk of adverse outcomes. Methods: A total of 4,776 patients formed 3 groups: those with AFF according to electrocardiography (ECG) at enrollment (n = 1,552; 33%), those with history of AFF but without AFF on ECG at enrollment (n = 1,005; 21%), and those without history of AFF or AFF on ECG at enrollment (n = 2,219, 46%). We assessed outcomes, treatment response to sacubitril/valsartan in each group, and the risk associated with first-detected AFF in patients without any known AFF. The primary outcome was a composite of total heart failure hospitalizations and cardiovascular death. Results: History of AFF and AFF at enrollment were associated with higher risk of the primary outcome (risk ratio [RR]: 1.36 [95% CI: 1.12-1.65] and RR: 1.31 [1.11-1.54], respectively), than no AFF. Neither history of AFF nor AFF at enrollment modified the treatment effect of sacubitril/valsartan. Post randomization AFF occurred in 12% of patients without previous AFF and was associated with 2.8-fold higher risk of the primary outcome, but it was not influenced by sacubitril/valsartan. Conclusions: History of AFF and AFF on ECG at enrollment were associated with a higher risk of the primary outcome. First-detected AFF was not influenced by sacubitril/valsartan, yet it was associated with increased risk of all subsequent outcomes and may represent a potential target for future HFpEF trials. (Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction [PARAGON-HF]; NCT01920711)
- Published
- 2022
8. A Computational Model for Prestressed Concrete Hollow-Core Slab Under Natural Fire
- Author
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Pečenko, R., Hozjan, T., Planinc, I., and Bratina, S.
- Published
- 2019
- Full Text
- View/download PDF
9. Analytical buckling of slender circular concrete-filled steel tubular columns with compliant interfaces
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Schnabl, S., Jelenić, G., and Planinc, I.
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- 2015
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10. Non-linear fire analysis of restrained curved RC beams
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Ružić, D., Kolšek, J., Planinc, I., Saje, M., and Hozjan, T.
- Published
- 2015
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11. A fully generalised approach to modelling fire response of steel–RC composite structures
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Kolšek, J., Saje, M., Planinc, I., and Hozjan, T.
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- 2014
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12. Slip-buckling analysis of longitudinally delaminated composite columns
- Author
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Kryžanowski, A., Planinc, I., and Schnabl, S.
- Published
- 2014
- Full Text
- View/download PDF
13. Fire Analysis of Timber Composite Beams with Interlayer Slip
- Author
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Australian Structural Engineering Conference (2008 : Melbourne, Vic.), Planinc, I, Hozjan, T, Turk, G, and Schnabl, S
- Published
- 2008
14. Finite Element Analysis of Composite Beams with Interlayer Slip
- Author
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Australian Structural Engineering Conference (2008 : Melbourne, Vic.), Schnabl, S, Hozjan, T, Turk, G, and Planinc, I
- Published
- 2008
15. Influence of creep on buckling of steel columns in fire conditions
- Author
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Dolinar, U., primary, Ogrin, A., additional, Planinc, I., additional, and Hozjan, T., additional
- Published
- 2017
- Full Text
- View/download PDF
16. Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial
- Author
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Cikes M., Planinc I., Claggett B., Cunningham J., Milicic D., Sweitzer N., Senni M., Gori M., Linssen G., Shah S. J., Packer M., Pfeffer M., Zile M. R., Anand I., Chiang L. -M., Lam C. S. P., Redfield M., Desai A. S., McMurray J. J. V., Solomon S. D., Cikes, M, Planinc, I, Claggett, B, Cunningham, J, Milicic, D, Sweitzer, N, Senni, M, Gori, M, Linssen, G, Shah, S, Packer, M, Pfeffer, M, Zile, M, Anand, I, Chiang, L, Lam, C, Redfield, M, Desai, A, Mcmurray, J, and Solomon, S
- Subjects
heart failure with preserved ejection fraction ,heart failure outcome ,sacubitril/valsartan ,echocardiography ,atrial fibrillation - Abstract
Objectives: In this study, the authors sought to assess the relationship between AFF and outcomes, the treatment response to sacubitril/valsartan and first-detected AFF in patients with HFpEF enrolled in the PARAGON-HF trial. Background: Atrial fibrillation and flutter (AFF) are common in heart failure with preserved ejection fraction (HFpEF) and increase the risk of adverse outcomes. Methods: A total of 4,776 patients formed 3 groups: those with AFF according to electrocardiography (ECG) at enrollment (n = 1,552; 33%), those with history of AFF but without AFF on ECG at enrollment (n = 1,005; 21%), and those without history of AFF or AFF on ECG at enrollment (n = 2,219, 46%). We assessed outcomes, treatment response to sacubitril/valsartan in each group, and the risk associated with first-detected AFF in patients without any known AFF. The primary outcome was a composite of total heart failure hospitalizations and cardiovascular death. Results: History of AFF and AFF at enrollment were associated with higher risk of the primary outcome (risk ratio [RR]: 1.36 [95% CI: 1.12-1.65] and RR: 1.31 [1.11-1.54], respectively), than no AFF. Neither history of AFF nor AFF at enrollment modified the treatment effect of sacubitril/valsartan. Post randomization AFF occurred in 12% of patients without previous AFF and was associated with 2.8-fold higher risk of the primary outcome, but it was not influenced by sacubitril/valsartan. Conclusions: History of AFF and AFF on ECG at enrollment were associated with a higher risk of the primary outcome. First-detected AFF was not influenced by sacubitril/valsartan, yet it was associated with increased risk of all subsequent outcomes and may represent a potential target for future HFpEF trials. (Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction [PARAGON-HF]; NCT01920711)
- Published
- 2022
17. The fire analysis of a steel–concrete side-plated beam
- Author
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Kolšek, J., Planinc, I., Saje, M., and Hozjan, T.
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- 2013
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- View/download PDF
18. Non-linear analysis of pre-tensioned concrete planar beams
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Markovič, M., Krauberger, N., Saje, M., Planinc, I., and Bratina, S.
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- 2013
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- View/download PDF
19. Exact buckling loads of two-layer composite Reissner’s columns with interlayer slip and uplift
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Schnabl, S. and Planinc, I.
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- 2013
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- View/download PDF
20. On strain softening in finite element analysis of RC planar frames subjected to fire
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Markovič, M., Saje, M., Planinc, I., and Bratina, S.
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- 2012
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21. Inelastic buckling load of a locally weakened reinforced concrete column
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Krauberger, N., Bratina, S., Saje, M., Schnabl, S., and Planinc, I.
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- 2012
- Full Text
- View/download PDF
22. Fire resistance of RC columns with regard to spalling of concrete
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Bajc, U., primary, Kolšek, J.Č., additional, Planinc, I., additional, and Bratina, S., additional
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- 2022
- Full Text
- View/download PDF
23. Buckling of asymmetrically delaminated three-dimensional composite beam: Analytical solution
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Kroflič, A., Saje, M., Planinc, I., and Zupan, D.
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- 2011
- Full Text
- View/download PDF
24. Non-linear analysis of two-layer beams with interlayer slip and uplift
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Kroflič, A., Saje, M., and Planinc, I.
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- 2011
- Full Text
- View/download PDF
25. The effect of transverse shear deformation on the buckling of two-layer composite columns with interlayer slip
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Schnabl, S. and Planinc, I.
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- 2011
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- View/download PDF
26. Inelastic buckling of two-layer composite columns with non-linear interface compliance
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Schnabl, S. and Planinc, I.
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- 2011
- Full Text
- View/download PDF
27. (386) - Lower Platelet Count Following Induction with Antithymocyte Globulin is Associated with a Lower Incidence of Cardiac Allograft Vasculopathy
- Author
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Fabijanovic, D., Mjehovic, P., Nekic, A., Jakus, N., Planinc, I., Pasalic, M., Jurin, H., Samardzic, J., Cikes, M., Gasparovic, H., Colak, Z., and Milicic, D.
- Published
- 2024
- Full Text
- View/download PDF
28. The influence of boundary conditions and axial deformability on buckling behavior of two-layer composite columns with interlayer slip
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Schnabl, S. and Planinc, I.
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- 2010
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- View/download PDF
29. Non-linear analysis of two-layer timber beams considering interlayer slip and uplift
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Kroflič, A., Planinc, I., Saje, M., Turk, G., and Čas, B.
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- 2010
- Full Text
- View/download PDF
30. Exact slip-buckling analysis of two-layer composite columns
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Kryžanowski, A., Schnabl, S., Turk, G., and Planinc, I.
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- 2009
- Full Text
- View/download PDF
31. Numerical and experimental analysis of timber composite beams with interlayer slip
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Planinc, I., Schnabl, S., Saje, M., Lopatič, J., and Čas, B.
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- 2008
- Full Text
- View/download PDF
32. Exact buckling analysis of composite elastic columns including multiple delamination and transverse shear
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Rodman, U., Saje, M., Planinc, I., and Zupan, D.
- Published
- 2008
- Full Text
- View/download PDF
33. Analytical solution for buckling of asymmetrically delaminated Reissner’s elastic columns including transverse shear
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Kryžanowski, A., Saje, M., Planinc, I., and Zupan, D.
- Published
- 2008
- Full Text
- View/download PDF
34. Poster session 4: Friday 5 December 2014, 08: 30–12: 30Location: Poster area
- Author
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Planinc, i, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, and Cikes, M
- Published
- 2014
35. Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
- Author
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Planinc I, Garcia-Canadilla P, Dejea H, Ilic I, Guasch E, MATIAS ZAMORA RODRÍGUEZ, Fàtima Crispi Brillas, Stampanoni M, Milicic D, Bijnens B, Bonnin A, and Cikes M
- Abstract
Cardiovascular research is in an ongoing quest for a superior imaging method to integrate gross-anatomical information with microanatomy, combined with quantifiable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in detail. The objective was to use X-PCI to comprehensively quantify ischemic remodeling of different myocardial structures, from cell to organ level, in a rat model of myocardial infarction. Myocardial infarction-induced remodeling was recreated in a well-established rodent model. Ex vivo rodent hearts were imaged by propagation based X-PCI using two configurations resulting in 5.8 µm and 0.65 µm effective pixel size images. The acquired datasets were used for a comprehensive assessment of macrostructural changes including the whole heart and vascular tree morphology, and quantification of left ventricular myocardial thickness, mass, volume, and organization. On the meso-scale, tissue characteristics were explored and compared with histopathological methods, while microstructural changes were quantified by segmentation of cardiomyocytes and calculation of cross-sectional areas. Propagation based X-PCI provides detailed visualization and quantification of morphological changes on whole organ, tissue, vascular as well as individual cellular level of the ex vivo heart, with a single, non-destructive 3D imaging modality.
- Published
- 2021
36. A heuristic viscosity-type dissipation for high frequency oscillation damping in time integration algorithms
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Gams, M., Planinc, I., and Saje, M.
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- 2007
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37. Locking-free two-layer Timoshenko beam element with interlayer slip
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Schnabl, S., Saje, M., Turk, G., and Planinc, I.
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- 2007
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38. Finite element dynamic analysis of geometrically exact planar beams
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Gams, M., Saje, M., Srpčič, S., and Planinc, I.
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- 2007
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39. Energy conserving time integration scheme for geometrically exact beam
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Gams, M., Planinc, I., and Saje, M.
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- 2007
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40. The strain-based beam finite elements in multibody dynamics
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Gams, M., Planinc, I., and Saje, M.
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- 2007
- Full Text
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41. Poster session Wednesday 11 December all day display: 11/12/2013, 09: 30–16: 00Location: Poster area
- Author
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Planinc, I, Bagadur, G, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Bijnens, B, Milicic, D, and Cikes, M
- Published
- 2013
42. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ, Novo S, Krum H, Varigos J, Siostrzonek P, Sinnaeve P, Gotcheva N, Yong H, Urina-Triana M, Milicic D, Vettus R, Manolis AJ, Wyss F, Sigurdsson A, Fucili A, Veze I, Petrauskiene B, Salvador L, Klemsdal TO, Medina F, Budaj A, Otasevic P, Lainscak M, Seung KB, Commerford P, Donath M, Hwang JJ, Kultursay H, Bilazarian S, East C, Forgosh L, Harris B, Ligueros M, Bohula E, Charmarthi B, Cheng S, Chou S, Danik J, McMahon G, Maron B, Ning M, Olenchock B, Pande R, Perlstein T, Pradhan A, Rost N, Singhal A, Taqueti V, Wei N, Burris H, Cioffi A, Dalseg AM, Ghosh N, Gralow J, Mayer T, Rugo H, Fowler V, Limaye AP, Cosgrove S, Levine D, Lopes R, Scott J, Hilkert R, Tamesby G, Mickel C, Manning B, Woelcke J, Tan M, Manfreda S, Ponce T, Kam J, Saini R, Banker K, Salko T, Nandy P, Tawfik R, O’Neil G, Manne S, Jirvankar P, Lal S, Nema D, Jose J, Collins R, Bailey K, Blumenthal R, Colhoun H, Gersh B, Abreu M, Actis MV, Aiub J, Aiub F, Albisu J, Alvarisqueta A, Avalos V, Barreto M, Berli MA, Blumberg C, Bocanera M, Botta C, Bowen L, Budassi N, Buhlman S, Westberg JC, Carabajal T, Caruso G, Casala J, Cendali G, Coloma G, Berra FC, Cuneo C, Degennaro N, Dellasa M, Diaz M, Dos Santos P, Espinosa V, Facello A, Facello M, Farias E, Fernandez AA, Ferrari V, Pacora FF, Flores GS, Franco M, Gabito A, Viola HG, Garcia F, Garcia Duran R, Garcia Pinna J, Glenny J, Godoy Sanchez M, Grosse A, Guzman P, Hasbani E, Hominal M, Ibañez J, Jure H, Jure D, Vico ML, Liniado G, Luciardi H, Luquez H, Maehara G, Maffei L, Majul C, Mallagray M, Marinaro S, Martinez J, Massaccesi R, De Los Milagros Had M, Azize GM, Montana O, Montenegro E, Morell Y, Muntaner J, Navarrete S, Olmedo M, Paganini M, Paz S, Perez Manghi F, Piskorz D, Polato C, Recoaro R, Romano A, Salinger M, Sanchez A, Saravia MA, Sarjanovich R, Scaro G, Schiavi LB, Soler J, Tinnirello V, Tomassi A, Valle M, Vallejo MA, Venturini C, Marcela Wenetz LM, Yossen M, Zaidman C, Zalazar L, Zangroniz P, Amerena J, Brady L, Colquhoun D, Eccleston D, Ferreira-Jardim A, French J, Jayasinghe R, Mcintosh C, Ord M, Plotz M, Purnell P, Roberts-Thomson P, Schultz C, Shanahan T, Tan R, Taverner P, Turner F, Vibert J, Vorster M, William M, Youssef G, Bergler-Klein J, Brath H, Brodmann M, Fliesser-Goerzer E, Haider K, Heeren G, Hiden C, Mandic L, Paulweber B, Ploechl A, Prenner A, Steringer-Mascherbauer R, Strohner-Kaestenbauer H, Barbato E, Bouvy C, Briké C, Charlier F, Cools F, De Knijf K, De Wolf L, Delforge M, Deweerdt N, Gits F, Goffinet C, Hermans K, Hollanders G, Mestdagh I, Pirenne B, Servaes V, Simons N, Tahon S, Theunissen E, Van Genechten G, Vervoort G, Vissers C, Vranckx P, Vrolix M, Abib E Jr, Abrantes J, Araujo Fonseca M, Barbosa E, Barroso W, Barroso A, Bodanese L, Botelho R, Costa Amorim R, Da Costa F, Da Silva A, Da Silva O Jr, Da Silva D Jr, Ferreira Dos Santos T, Dos Santos F, Dos Santos A, Duda N, Feitosa G, Felario Junior GA, Ferraz R, Filho P, Fonseca A, Wanderley FF, Freitas E, Fucci F, Marengo Garcia De Carvalho L, Hernandez M, Hettwer Magedanz E, Julião K, Kormann A, Lameira A, Lima F, Lino E, Maia L, Manenti E, Marchi AL, Fischer SM, Michalaros Y, Moraes J Jr, Moreira L, Pagnan M, Pesce F, Pinheiro L, Rassi S, Reis G, Reis H, Resende I, Roel A, Ruschel K, Saporito W, Saraiva JF, Seroqui M, Silva R, Unterkircher B, Vicente C, Vieira N, Xavier JP, Zucchetti C, Angelova I, Dimitrov G, Genova D, Gospodinov K, Goudev A, Grigorova V, Hristova K, Makedonska JJ, Katova T, Kostov K, Lazov P, Manov E, Manukov I, Manukov D, Milanova M, Kabakchieva VM, Petrov D, Petrusheva T, Pramatarova I, Raev D, Runev N, Sirakova-Taseva A, Tisheva-Gospodinova S, Todorova A, Tzekova M, Yakovova S, Yanev T, Abulencia K, Arora S, Baker A, Bata IR, Beaudry M, Belle Isle J, Bilodeau N, Boivin MC, Bolduc H, Bourgeois S, Brons S, Cantor W, Chaussé I, Chhabra A, Chouinard G, Cleveland T, Dattani D, Deslongchamps F, Diodati J, Drouin K, Duchesne L, Fontaine S, d'Amours DG, Gervais B, Gosselin G, Graham J, Grover A, Gupta A, Haldane H, Hartleib M, Hickey L, Huynh T, Johnston J, Julien VE, Lachance P, Lake J, Lamontagne C, Lauzon C, Lepage S, Maheux K, Manyari D, Martin E, McPherson C, Mehta S, Michaud N, Kouz SM, Murphy G, OKeefe D, Otis R, Ouimet F, Pandey S, Peck C, Perkins L, Richert L, Robbins K, Robinson S, Cabau JR, Ross B, Roy C, Roy M, Roy A, Rupka D, Affaki GS, Saunders K, Savard D, Soucy D, St Amour E, Thiessen S, Vertes G, Vezina M, Vincelli G, Weisnagel SJ, Zadra R, Chen J, Chen Y, Dong X, Feng Y, Feng Z, Fu G, Han B, Hao Y, He Y, He Z, Hong T, Jia Z, Jiang T, Jiang J, Jiang X, Ke Y, Li Y, Li Z, Li W, Li X, Liu P, Liu Y, Liu B, Liu S, Liu L, Lu Z, Lv Y, Ma C, Ma G, Peng L, Qing L, Ren 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M., Everett, B. M., Thuren, T., Macfadyen, J. G., Chang, W. H., Ballantyne, C., FONSECA E PIRES, CARLOS EDUARDO, Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., Vida-Simiti, L., Flather, M., Shimokawa, H., Ogawa, H., Dellborg, M., Rossi, P. R. F., Troquay, R. P. T., Libby, P., Glynn R., J, CANTOS Trial, Group, Perrone, Filardi, P, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes
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0301 basic medicine ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,c-reactive protein ,Randomized controlled trial ,law ,Cardiovascular Disease ,middle aged ,double-blind method ,antibodies ,Myocardial infarction ,humans ,Stroke ,interleukin-1beta ,biology ,Antibodies, Monoclonal ,drug ,General Medicine ,Lipid ,Aged ,anti-inflammatory agents ,monoclonal ,humanized ,atherosclerosis ,cardiovascular diseases ,dose-response relationship ,female ,incidence ,infections ,lipids ,male ,myocardial infarction ,neutropenia ,secondary prevention ,stroke ,Anti-Inflammatory Agent ,aged ,Editorial ,Atherosclerosi ,Monoclonal ,Human ,medicine.drug ,medicine.medical_specialty ,Neutropenia ,Antibodies, Monoclonal, Humanized ,Infections ,Placebo ,antibodies, monoclonal ,dose-response relationship, drug ,infection ,medicine (all) ,03 medical and health sciences ,Internal medicine ,medicine ,Dose-Response Relationship, Drug ,business.industry ,Antiinflammatory Therapy, Canakinumab, for Atherosclerotic Disease ,C-reactive protein ,medicine.disease ,Surgery ,Canakinumab ,030104 developmental biology ,biology.protein ,business - Abstract
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.)
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- 2017
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43. Non-linear finite element analysis of composite planar frames with an interlayer slip
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Čas, B., Saje, M., and Planinc, I.
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- 2004
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44. On materially and geometrically non-linear analysis of reinforced concrete planar frames
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Bratina, S., Saje, M., and Planinc, I.
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- 2004
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45. Influence of moisture on fire resistance of side-plated RC beams
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Kolšek J., Saje M., Planinc I., and Hozjan T.
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The objective of the paper is to present the effect of moisture in concrete on the fire resistance of side-plated reinforced concrete (RC) beams. For this purpose an adequate new finite-element (FE) procedure is presented. The paper concludes with a parametric study, examining the impacts of the vapor-tight side plates, high initial moisture content and low initial permeability of concrete of the selected RC beam on the rate of the risk of concrete spalling.
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- 2013
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46. Safety of sacubitril-valsartan vs. ramipril in left ventricular assist device carriers and comparison of NTproBNP levels - a pilot study
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Jakus, N, Ister, R, Planinc, I, Skoric, B, Jurin, H, Samardzic , J, Lovric, D, Ljubas Macek, J, Fabijanovic, D, Milicic, D, and Cikes, M.
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sacubitril-valsartan, left ventricular assist device - Abstract
Background: Currently, there is no consensus on the optimal medical therapy for patients after left ventricular assist device (LVAD) implantation, but usually the HFrEF therapy is continued beyond implant. We compared NT-proBNP values in LVAD patients treated with ramipril or sacubitril/valsartan (sac/val).Patient sand Methods: A single centre, retrospective study included data from 26 patients(88% male, mean age 59±11 years). 54% were continuously treated with ramipril, and 46% were switched to sac/val. The median follow-up was 13.3 months(IQR 8.5-15.4).Results:Baseline patient data are presented in Table 1. Throughout the followup, the mean arterial blood pressure, creatinine and glomerular filtration rate (GFR)values did not change significantly (Figure 1a). A decrease in NT-proBNP values was noted in both groups, although without significant difference between them. However, a difference in trends expressed as negative logarithms of ratios of NT- proBNPat 3 months follow up and at baseline is seen in the sac/val group compared to those on ramipril, achieving significance (p=0.009) for the low medication doses(Figure 1b). During follow-up, 3 patients died in the ramipril subgroup and none in the sac/val group, but the sample size precluded survival analyses.Conclusion: Our data suggest a good safety profile of sac/val in LVAD recipients. A decrease in NT-proBNP values is seen in patients in both treatment groups, with results suggestive of a decrease in the biomarker with sac/val. However, a larger prospective randomized study is required to establish the consistency of this finding and its translation to treatment benefit.
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- 2019
47. Implementing coupled heat and moisture transfer model in the fire analysis of timber beams
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Pečenko, R., primary, Planinc, I., additional, Svensson, S., additional, and Hozjan, T., additional
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- 2019
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48. The Control of Varroa destructor Using Oxalic Acid
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Gregorc, A. and Planinc, I.
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- 2002
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49. A quadratically convergent algorithm for the computation of stability points: The application of the determinant of the tangent stiffness matrix
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Planinc, I. and Saje, M.
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- 1999
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50. The occurrence of interatrial dyssynchrony in heart failure across the spectrum of ejection fraction
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Cikes, M, Fabijanovic, D, Planinc, I, Skoric, B, Lovric, D, Ljubas Macek, J, Jakus, N, Jurin, H, Samardzic, J, Bijnens, B, and Milicic, D
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cardiovascular system ,interatrial dyssynchrony, heart failure ,cardiovascular diseases - Abstract
Purpose:Heart failure with preserved EF (HFpEF) is characterized by phenotypicheterogeneity. Loss of atrial function is of relevance in HFpEF, and interatrialdyssynchrony (IAD) appears to be one of its aspects. The prevalence of IAD hasnot been compared between patients with HF and various categories of LVEF.Methods:Data from 51 patients (24 HFpEF, 6 HFmrEF, 21 HFrEF) diagnosed with HFper current guidelines were analyzed retrospectively. IAD was measured from echoDoppler traces as the difference between the time of transmitral and transtricuspidA wave onsets.Results:IAD>60 ms was present in 8 HFpEF pts. (33.3%), 1 HFrEF (4.8%) and1 HFmrEF patient (16.7%) (p=0.039). Compared to pts. with LVEF
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- 2017
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