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1. Author Correction: Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells

Author

Tessier, Sarah, Ferhi, Omar, Geoffroy, Marie-Claude, González-Prieto, Román, Canat, Antoine, Quentin, Samuel, Pla, Marika, Niwa-Kawakita, Michiko, Bercier, Pierre, Rérolle, Domitille, Tirard, Marilyn, Therizols, Pierre, Fabre, Emmanuelle, Vertegaal, Alfred C. O., de Thé, Hugues, and Lallemand-Breitenbach, Valérie

Published
2023
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4. Abstract 464: AAC-11 survival pathways as therapeutic target in cancer: AAC-11 leucine-zipper domain derived peptides exert potent antitumor effects and exhibit favorable stability, pharmacokinetic and toxicology profiles

Author

Jeammet, Louise, primary, Adicéam, Emile, additional, Habault, Justine, additional, Kaci, Anna, additional, Berrou, Jeannig, additional, Dupont, Mélanie, additional, Thonnart, Nicolas, additional, Pasquereau-Kotula, Ewa, additional, Marie-Cardine, Anne, additional, Bensussan, Armand, additional, Pla, Marika, additional, Dombret, Hervé, additional, Gardin, Claude, additional, Bagot, Martine, additional, Rain, Jean-Christophe, additional, Sicard, Hélène, additional, Tiollier, Jérôme, additional, Braun, Thorsten, additional, and Poyet, Jean-Luc, additional

Published
2023
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5. Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Gachet, Stéphanie, primary, El-Chaar, Tiama, primary, Avran, David, primary, Genesca, Eulalia, primary, Catez, Frédéric, primary, Quentin, Samuel, primary, Delord, Marc, primary, Thérizols, Gabriel, primary, Briot, Delphine, primary, Meunier, Godelieve, primary, Hernandez, Lucie, primary, Pla, Marika, primary, Smits, Willem K., primary, Buijs-Gladdines, Jessica G., primary, Van Loocke, Wouter, primary, Menschaert, Gerben, primary, André-Schmutz, Isabelle, primary, Taghon, Tom, primary, Van Vlierberghe, Pieter, primary, Meijerink, Jules P., primary, Baruchel, André, primary, Dombret, Hervé, primary, Clappier, Emmanuelle, primary, Diaz, Jean-Jacques, primary, Gazin, Claude, primary, de Thé, Hugues, primary, Sigaux, François, primary, and Soulier, Jean, primary

Published
2023
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6. Table S4 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Gachet, Stéphanie, primary, El-Chaar, Tiama, primary, Avran, David, primary, Genesca, Eulalia, primary, Catez, Frédéric, primary, Quentin, Samuel, primary, Delord, Marc, primary, Thérizols, Gabriel, primary, Briot, Delphine, primary, Meunier, Godelieve, primary, Hernandez, Lucie, primary, Pla, Marika, primary, Smits, Willem K., primary, Buijs-Gladdines, Jessica G., primary, Van Loocke, Wouter, primary, Menschaert, Gerben, primary, André-Schmutz, Isabelle, primary, Taghon, Tom, primary, Van Vlierberghe, Pieter, primary, Meijerink, Jules P., primary, Baruchel, André, primary, Dombret, Hervé, primary, Clappier, Emmanuelle, primary, Diaz, Jean-Jacques, primary, Gazin, Claude, primary, de Thé, Hugues, primary, Sigaux, François, primary, and Soulier, Jean, primary

Published
2023
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7. Supplementary Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Gachet, Stéphanie, primary, El-Chaar, Tiama, primary, Avran, David, primary, Genesca, Eulalia, primary, Catez, Frédéric, primary, Quentin, Samuel, primary, Delord, Marc, primary, Thérizols, Gabriel, primary, Briot, Delphine, primary, Meunier, Godelieve, primary, Hernandez, Lucie, primary, Pla, Marika, primary, Smits, Willem K., primary, Buijs-Gladdines, Jessica G., primary, Van Loocke, Wouter, primary, Menschaert, Gerben, primary, André-Schmutz, Isabelle, primary, Taghon, Tom, primary, Van Vlierberghe, Pieter, primary, Meijerink, Jules P., primary, Baruchel, André, primary, Dombret, Hervé, primary, Clappier, Emmanuelle, primary, Diaz, Jean-Jacques, primary, Gazin, Claude, primary, de Thé, Hugues, primary, Sigaux, François, primary, and Soulier, Jean, primary

Published
2023
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11. Data from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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12. Data from BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

Author

Omidvar, Nader, primary, Kogan, Scott, primary, Beurlet, Stephanie, primary, le Pogam, Carole, primary, Janin, Anne, primary, West, Robert, primary, Noguera, Maria-Elena, primary, Reboul, Murielle, primary, Soulie, Annie, primary, Leboeuf, Christophe, primary, Setterblad, Niclas, primary, Felsher, Dean, primary, Lagasse, Eric, primary, Mohamedali, Azim, primary, Thomas, N. Shaun B., primary, Fenaux, Pierre, primary, Fontenay, Michaela, primary, Pla, Marika, primary, Mufti, Ghulam J., primary, Weissman, Irving, primary, Chomienne, Christine, primary, and Padua, Rose Ann, primary

Published
2023
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13. Supplementary Procedures, Figures 1-4 from BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

Author

Omidvar, Nader, primary, Kogan, Scott, primary, Beurlet, Stephanie, primary, le Pogam, Carole, primary, Janin, Anne, primary, West, Robert, primary, Noguera, Maria-Elena, primary, Reboul, Murielle, primary, Soulie, Annie, primary, Leboeuf, Christophe, primary, Setterblad, Niclas, primary, Felsher, Dean, primary, Lagasse, Eric, primary, Mohamedali, Azim, primary, Thomas, N. Shaun B., primary, Fenaux, Pierre, primary, Fontenay, Michaela, primary, Pla, Marika, primary, Mufti, Ghulam J., primary, Weissman, Irving, primary, Chomienne, Christine, primary, and Padua, Rose Ann, primary

Published
2023
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14. Supplementary Table 1 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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15. Supplementary Figure 1 Legend from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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16. Supplementary Figure 1 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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17. Supplementary Table 2 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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18. Supplementary Table 5 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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19. Supplementary Table 3 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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20. Supplementary Table 4 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
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21. Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance

Author

Sroka, Ewa Maria, primary, Lavigne, Mathilde, additional, Pla, Marika, additional, Daskalogianni, Chrysoula, additional, Tovar-Fernandez, Maria Camila, additional, Prado Martins, Rodrigo, additional, Manoury, Bénédicte, additional, Darrasse-Jéze, Guillaume, additional, Nascimento, Megane, additional, Apcher, Sebastien, additional, and Fåhraeus, Robin, additional

Published
2023
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22. BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

Author

Beurlet, Stephanie, Omidvar, Nader, Gorombei, Petra, Krief, Patricia, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, Leboeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Hervatin, Florence, Sarda-Mantel, Laure, Konopleva, Marina, Andreeff, Michael, Tu, Andrea W., Fan, Alice C., Felsher, Dean W., Whetton, Anthony, Pla, Marika, West, Robert, Fenaux, Pierre, Chomienne, Christine, and Padua, Rose Ann

Published
2013
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23. Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes

Author

Le Pogam, Carole, Krief, Patricia, Beurlet, Stephanie, Soulié, Annie, Balitrand, Nicole, Cassinat, Bruno, Cavé, Helene, Kosmider, Olivier, Setterblad, Niclas, Leboeuf, Christophe, Sarda-Mantel, Laure, Hervatin, Florence, Merlet, Pascal, Noguera, Maria-Elena, Janin, Anne, Pla, Marika, Fontenay, Michaela, Adès, Lionel, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann, and Omidvar, Nader

Published
2013
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25. Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells

Author

Universidad de Sevilla. Departamento de Biología Celular, Tessier, Sarah, Ferhi, Omar, Geoffroy, Marie-Claude, González Prieto, Román, Canat, Antoine, Quentin, Samuel, Pla, Marika, Niwa-Kawakita, Michiko, Bercier, Pierre, Rerolle, Domitille, Therizols, Pierre, Fabre, Emmanuelle, Vertegaal, Alfred C. O., de Thé, Hugues, Lallemand-Breitenbach, Valerie, Universidad de Sevilla. Departamento de Biología Celular, Tessier, Sarah, Ferhi, Omar, Geoffroy, Marie-Claude, González Prieto, Román, Canat, Antoine, Quentin, Samuel, Pla, Marika, Niwa-Kawakita, Michiko, Bercier, Pierre, Rerolle, Domitille, Therizols, Pierre, Fabre, Emmanuelle, Vertegaal, Alfred C. O., de Thé, Hugues, and Lallemand-Breitenbach, Valerie

Abstract

Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation. PML NBs recruit many partner proteins, but the actual biochemical mechanism underlying their pleiotropic functions remains elusive. Similarly, PML role in embryonic stem cell (ESC) and retro-element biology is unsettled. Here we demonstrate that PML is essential for oxidative stress-driven partner SUMO2/3 conjugation in mouse ESCs (mESCs) or leukemia, a process often followed by their poly-ubiquitination and degradation. Functionally, PML is required for stress responses in mESCs. Differential proteomics unravel the KAP1 complex as a PML NB-dependent SUMO2-target in arsenic-treated APL mice or mESCs. PML-driven KAP1 sumoylation enables activation of this key epigenetic repressor implicated in retro-element silencing. Accordingly, Pml−/− mESCs re-express transposable elements and display 2-Cell-Like features, the latter enforced by PML-controlled SUMO2-conjugation of DPPA2. Thus, PML orchestrates mESC state by coordinating SUMO2-conjugation of different transcriptional regulators, raising new hypotheses about PML roles in cancer.

Published
2022

26. Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells

Author

Agence Nationale de la Recherche (France), European Commission, Association de la Recherche Contre le Cancer (France), Tessier, Sarah, Ferhi, Omar, Geoffroy, Marie-Claude, González-Prieto, Román, Canat, Antoine, Quentin, Samuel, Pla, Marika, Niwa-Kawakita, Michiko, Bercier, Pierre, Rérolle, Domitille, Tirard, Marilyn, Therizols, Pierre, Fabre, Emmanuelle, Vertegaal, Alfred C. O., Thé, Hugues de, Lallemand-Breitenbach, Valérie, Agence Nationale de la Recherche (France), European Commission, Association de la Recherche Contre le Cancer (France), Tessier, Sarah, Ferhi, Omar, Geoffroy, Marie-Claude, González-Prieto, Román, Canat, Antoine, Quentin, Samuel, Pla, Marika, Niwa-Kawakita, Michiko, Bercier, Pierre, Rérolle, Domitille, Tirard, Marilyn, Therizols, Pierre, Fabre, Emmanuelle, Vertegaal, Alfred C. O., Thé, Hugues de, and Lallemand-Breitenbach, Valérie

Abstract

Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation. PML NBs recruit many partner proteins, but the actual biochemical mechanism underlying their pleiotropic functions remains elusive. Similarly, PML role in embryonic stem cell (ESC) and retro-element biology is unsettled. Here we demonstrate that PML is essential for oxidative stress-driven partner SUMO2/3 conjugation in mouse ESCs (mESCs) or leukemia, a process often followed by their poly-ubiquitination and degradation. Functionally, PML is required for stress responses in mESCs. Differential proteomics unravel the KAP1 complex as a PML NB-dependent SUMO2-target in arsenic-treated APL mice or mESCs. PML-driven KAP1 sumoylation enables activation of this key epigenetic repressor implicated in retro-element silencing. Accordingly, Pml mESCs re-express transposable elements and display 2-Cell-Like features, the latter enforced by PML-controlled SUMO2-conjugation of DPPA2. Thus, PML orchestrates mESC state by coordinating SUMO2-conjugation of different transcriptional regulators, raising new hypotheses about PML roles in cancer.

Published
2022

27. BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome

Author

Gorombei, Petra, primary, Guidez, Fabien, additional, Ganesan, Saravanan, additional, Chiquet, Mathieu, additional, Pellagatti, Andrea, additional, Goursaud, Laure, additional, Tekin, Nilgun, additional, Beurlet, Stephanie, additional, Patel, Satyananda, additional, Guerenne, Laura, additional, Le Pogam, Carole, additional, Setterblad, Niclas, additional, de la Grange, Pierre, additional, LeBoeuf, Christophe, additional, Janin, Anne, additional, Noguera, Maria-Elena, additional, Sarda-Mantel, Laure, additional, Merlet, Pascale, additional, Boultwood, Jacqueline, additional, Konopleva, Marina, additional, Andreeff, Michael, additional, West, Robert, additional, Pla, Marika, additional, Adès, Lionel, additional, Fenaux, Pierre, additional, Krief, Patricia, additional, Chomienne, Christine, additional, Omidvar, Nader, additional, and Padua, Rose Ann, additional

Published
2021
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29. Unbiased in vivo exploration of nuclear bodies-enhanced sumoylation reveals that PML orchestrates embryonic stem cell fate

Author

Tessier, Sarah, primary, Ferhi, Omar, additional, Geoffroy, Marie-Claude, additional, Gonzalez-Prieto, Roman, additional, Canat, Antoine, additional, Quentin, Samuel, additional, Pla, Marika, additional, Niwa-Kawakita, Michiko, additional, Bercier, Pierre, additional, Rérolle, Domitille, additional, Therizols, Pierre, additional, Fabre, Emmanuelle, additional, Vertegaal, Alfred C.O., additional, de Thé, Hugues, additional, and Lallemand-Breitenbach, Valérie, additional

Published
2021
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30. Prophylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53

Author

Habault, Justine, Kaci, Anna, Pasquereau-Kotula, Ewa, Fraser, Claire, Chomienne, Christine, Dombret, Hervé, Braun, Thorsten, Pla, Marika, and Poyet, Jean-Luc

Subjects
autologous tumor cell vaccine, Brief Report, T-Lymphocytes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC581-607, anticancer peptide, tumor immunity, Leukemia, Myeloid, Acute, Mice, Leukemia, Promyelocytic, Acute, Animals, Humans, acute leukemia, Immunologic diseases. Allergy, Peptides, RC254-282
Abstract

Despite considerable progress, the treatment of acute leukemia continues to be a challenge for a significant majority of patients. Using a well-characterized preclinical mouse model of acute promyelocytic leukemia (APL), we evaluated here the antileukemic efficacy of RT53, an anticancer peptide with potential immunological properties. Our results indicate that RT53 possesses a direct antileukemic effect, even at a late stage. We also demonstrate that a single injection of a vaccine consisting of leukemic blasts exposed to RT53, which induces the hallmarks of immunogenic cell death, was highly effective in preventing leukemia development in both prophylactic and therapeutic settings. The vaccine comprising RT53-treated APL cells generated long-term antileukemic protection and depletion experiments indicated that CD4 + T cells were of crucial importance for vaccine efficacy. Combined, our results provide the rationale for the exploration of RT53-based therapies for the treatment of acute leukemia.

Published
2020

31. PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia

Author

Padua, Rose Ann, Larghero, Jerome, Robin, Marie, Pogam, Carol le, Schlageter, Marie-Helene, Muszlak, Sacha, Fric, Jan, West, Robert, Rousselot, Philippe, Phan, Thi Hai, Mudde, Liesbeth, Teisserenc, Helene, Carpentier, Antoine F, Kogan, Scott, Degos, Laurent, Pla, Marika, Bishop, J Michael, Stevenson, Freda, Charron, Dominique, and Chomienne, Christine

Abstract

Author(s): Rose Ann Padua (corresponding author) [1, 2]; Jerome Larghero [1]; Marie Robin [1]; Carol le Pogam [1]; Marie-Helene Schlageter [1]; Sacha Muszlak [2]; Jan Fric [1]; Robert West [3]; [...]

Published
2003
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33. Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides

Author

Martins, Rodrigo Prado, Malbert-Colas, Laurence, Lista, Maria Jose, Daskalogianni, Chrysoula, Apcher, Sebastien, Pla, Marika, Findakly, Sarah, Blondel, Marc, Fåhraeus, Robin, Martins, Rodrigo Prado, Malbert-Colas, Laurence, Lista, Maria Jose, Daskalogianni, Chrysoula, Apcher, Sebastien, Pla, Marika, Findakly, Sarah, Blondel, Marc, and Fåhraeus, Robin

Abstract

Peptides presented on major histocompatibility (MHC) class I molecules form an essential part of the immune system's capacity to detect virus-infected or transformed cells. Earlier works have shown that pioneer translation peptides (PTPs) for the MHC class I pathway are as efficiently produced from introns as from exons, or from mRNAs targeted for the nonsense-mediated decay pathway. The production of PTPs is a target for viral immune evasion but the underlying molecular mechanisms that govern this non-canonical translation are unknown. Here, we have used different approaches to show how events taking place on the nascent transcript control the synthesis of PTPs and full-length proteins. By controlling the subcellular interaction between the G-quadruplex structure (G4) of a gly-ala encoding mRNA and nucleolin (NCL) and by interfering with mRNA maturation using multiple approaches, we demonstrate that antigenic peptides derive from a nuclear non-canonical translation event that is independently regulated from the synthesis of full-length proteins. Moreover, we show that G4 are exploited to control mRNA localization and translation by distinguishable mechanisms that are targets for viral immune evasion.

Published
2019
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42. Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Gachet, Stéphanie, primary, El-Chaar, Tiama, additional, Avran, David, additional, Genesca, Eulalia, additional, Catez, Frédéric, additional, Quentin, Samuel, additional, Delord, Marc, additional, Thérizols, Gabriel, additional, Briot, Delphine, additional, Meunier, Godelieve, additional, Hernandez, Lucie, additional, Pla, Marika, additional, Smits, Willem K., additional, Buijs-Gladdines, Jessica G., additional, Van Loocke, Wouter, additional, Menschaert, Gerben, additional, André-Schmutz, Isabelle, additional, Taghon, Tom, additional, Van Vlierberghe, Pieter, additional, Meijerink, Jules P., additional, Baruchel, André, additional, Dombret, Hervé, additional, Clappier, Emmanuelle, additional, Diaz, Jean-Jacques, additional, Gazin, Claude, additional, de Thé, Hugues, additional, Sigaux, François, additional, and Soulier, Jean, additional

Published
2018
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43. BCL-2 Inhibitor Venetoclax (ABT-199) and MEK Inhibitor GDC-0973 Synergise to Target AML Progenitors and Overcome Drug Resistance with the Use of PET Scanning in a Mouse Model of HR-MDS to Monitor Response to Treatment

Author

Padua, Rose Ann, primary, Sarda-Mantel, Laure, additional, Chiquet, Mathieu, additional, Kappel, Claire, additional, Krief, Patricia, additional, Setterblad, Niclas, additional, Hontonnou, Fortune, additional, Hosten, Benoit, additional, Vignal, Nicolas, additional, Zassadowski, Fabien, additional, Cassinat, Bruno, additional, Gou, Panhong, additional, Giraudier, Stephane, additional, Konopleva, Marina Y., additional, Andreeff, Michael, additional, PLA, Marika, additional, Ades, Lionel, additional, Fenaux, Pierre, additional, and Chomienne, Christine, additional

Published
2018
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44. Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia

Author

Domenech, Carine, primary, Maillard, Loïc, additional, Rousseau, Alix, additional, Guidez, Fabien, additional, Petit, Laurence, additional, Pla, Marika, additional, Clay, Denis, additional, Guimiot, Fabien, additional, Sanfilippo, Sandra, additional, Jacques, Sebastien, additional, de la Grange, Pierre, additional, Robil, Noémie, additional, Soulier, Jean, additional, and Souyri, Michèle, additional

Published
2018
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