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18 results on '"Plaça, Desirée Rodrigues"'

1. Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach

Author

Fonseca, Dennyson Leandro M., Filgueiras, Igor Salerno, Marques, Alexandre H. C., Vojdani, Elroy, Halpert, Gilad, Ostrinski, Yuri, Baiocchi, Gabriela Crispim, Plaça, Desirée Rodrigues, Freire, Paula P., Pour, Shahab Zaki, Moll, Guido, Catar, Rusan, Lavi, Yael Bublil, Silverberg, Jonathan I., Zimmerman, Jason, Cabral-Miranda, Gustavo, Carvalho, Robson F., Khan, Taj Ali, Heidecke, Harald, Dalmolin, Rodrigo J. S., Luchessi, Andre Ducati, Ochs, Hans D., Schimke, Lena F., Amital, Howard, Riemekasten, Gabriela, Zyskind, Israel, Rosenberg, Avi Z., Vojdani, Aristo, Shoenfeld, Yehuda, and Cabral-Marques, Otavio

Published
2023
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2. Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities

Author

Borges, Lysandro P., Guimarães, Adriana G., Fonseca, Dennyson Leandro M., Freire, Paula P., Barreto, Íkaro D.C., Souza, Daniela R.V., Gurgel, Ricardo Q., Lopes, Aline S.A., Melquiades de Rezende Neto, José, dos Santos, Kezia A., Matos, Igor L.S., da Invenção, Grazielly B., Oliveira, Brenda M., Santos, Aryanne A., Soares, Daniele Almeida, de Jesus, Pamela C., dos Santos, Cliomar A., Goes, Marco A.O., Plaça, Desirée Rodrigues, Filgueiras, Igor Salerno, Marques, Alexandre H.C., Baiocchi, Gabriela Crispim, Cabral-Miranda, William, Cabral de Miranda, Gustavo, Saraiva Camara, Niels Olsen, Garcia Calich, Vera Lúcia, Ramos, Rodrigo Nalio, Nakaya, Helder I., Rocha, Vanderson, Giil, Lasse M., Ochs, Hans D., Schimke, Lena F., de Souza, Mércia S.F., Cuevas, Luis E., Martins, Aline F., and Cabral-Marques, Otavio

Published
2022
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3. Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity

Author

Cabral-Marques, Otavio, Halpert, Gilad, Schimke, Lena F., Ostrinski, Yuri, Vojdani, Aristo, Baiocchi, Gabriela Crispim, Freire, Paula Paccielli, Filgueiras, Igor Salerno, Zyskind, Israel, Lattin, Miriam T., Tran, Florian, Schreiber, Stefan, Marques, Alexandre H. C., Plaça, Desirée Rodrigues, Fonseca, Dennyson Leandro M., Humrich, Jens Y., Müller, Antje, Giil, Lasse M., Graßhoff, Hanna, Schumann, Anja, Hackel, Alexander, Junker, Juliane, Meyer, Carlotta, Ochs, Hans D., Lavi, Yael Bublil, Scheibenbogen, Carmen, Dechend, Ralf, Jurisica, Igor, Schulze-Forster, Kai, Silverberg, Jonathan I., Amital, Howard, Zimmerman, Jason, Heidecke, Harry, Rosenberg, Avi Z., Riemekasten, Gabriela, and Shoenfeld, Yehuda

Published
2022
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4. Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection

Author

Plaça, Desirée Rodrigues, primary, Fonseca, Dennyson Leandro M., additional, Marques, Alexandre H. C., additional, Zaki Pour, Shahab, additional, Usuda, Júlia Nakanishi, additional, Baiocchi, Gabriela Crispim, additional, Prado, Caroline Aliane de Souza, additional, Salgado, Ranieri Coelho, additional, Filgueiras, Igor Salerno, additional, Freire, Paula Paccielli, additional, Rocha, Vanderson, additional, Camara, Niels Olsen Saraiva, additional, Catar, Rusan, additional, Moll, Guido, additional, Jurisica, Igor, additional, Calich, Vera Lúcia Garcia, additional, Giil, Lasse M., additional, Rivino, Laura, additional, Ochs, Hans D., additional, Cabral-Miranda, Gustavo, additional, Schimke, Lena F., additional, and Cabral-Marques, Otavio, additional

Published
2024
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5. The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

Author

Salgado, Ranieri Coelho, Fonseca, Dennyson Leandro M., Marques, Alexandre H. C., da Silva Napoleao, Sarah Maria, França, Tábata Takahashi, Akashi, Karen Tiemi, de Souza Prado, Caroline Aliane, Baiocchi, Gabriela Crispim, Plaça, Desirée Rodrigues, Jansen-Marques, Gabriel, Filgueiras, Igor Salerno, De Vito, Roberta, Freire, Paula Paccielli, de Miranda, Gustavo Cabral, Camara, Niels Olsen Saraiva, Calich, Vera Lúcia Garcia, Ochs, Hans D., Schimke, Lena F., Jurisica, Igor, Condino-Neto, Antonio, and Cabral-Marques, Otavio

Published
2021
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6. Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization

Author

Usuda, Júlia Nakanishi, primary, Plaça, Desirée Rodrigues, additional, Fonseca, Dennyson Leandro M., additional, Marques, Alexandre H. C., additional, Filgueiras, Igor Salerno, additional, Chaves, Victor Gabriel Bastos, additional, Adri, Anny Silva, additional, Torrentes-Carvalho, Amanda, additional, Hirata, Mario Hiroyuki, additional, Freire, Paula Paccielli, additional, Catar, Rusan, additional, Cabral-Miranda, Gustavo, additional, Schimke, Lena F., additional, Moll, Guido, additional, and Cabral-Marques, Otavio, additional

Published
2023
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7. Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort study

Author

Reis, Bárbara Carvalho Santos Dos, primary, Soares Faccion, Roberta, additional, de Carvalho, Flavia Amendola Anisio, additional, Moore, Daniella Campelo Batalha Cox, additional, Zuma, Maria Celia Chaves, additional, Plaça, Desirée Rodrigues, additional, Salerno Filgueiras, Igor, additional, Leandro Mathias Fonseca, Dennyson, additional, Cabral-Marques, Otavio, additional, Bonomo, Adriana Cesar, additional, Savino, Wilson, additional, Freitas, Flávia Cristina de Paula, additional, Faoro, Helisson, additional, Passetti, Fabio, additional, Robaina, Jaqueline Rodrigues, additional, de Oliveira, Felipe Rezende Caino, additional, Novaes Bellinat, Ana Paula, additional, Zeitel, Raquel de Seixas, additional, Salú, Margarida dos Santos, additional, de Oliveira, Mariana Barros Genuíno, additional, Rodrigues-Santos, Gustavo, additional, Prata-Barbosa, Arnaldo, additional, and Vasconcelos, Zilton Farias Meira de, additional

Published
2023
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8. Corrigendum to “Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities” [Heliyon 8 (11) (November 2022) Article e11368]

Author

Borges, Lysandro P., primary, Guimarães, Adriana G., additional, Fonseca, Dennyson Leandro M., additional, Freire, Paula P., additional, Barreto, Íkaro D.C., additional, Souza, Daniela R.V., additional, Gurgel, Ricardo Q., additional, Lopes, Aline S.A., additional, Melquiades de Rezende Neto, José, additional, dos Santos, Kezia A., additional, Matos, Igor L.S., additional, da Invenção, Grazielly B., additional, Oliveira, Brenda M., additional, Santos, Aryanne A., additional, Soares, Daniele Almeida, additional, de Jesus, Pamela C., additional, dos Santos, Cliomar A., additional, Goes, Marco A.O., additional, Plaça, Desirée Rodrigues, additional, Filgueiras, Igor Salerno, additional, Marques, Alexandre H.C., additional, Baiocchi, Gabriela Crispim, additional, CabralMiranda, William, additional, Cabral de Miranda, Gustavo, additional, Saraiva Camara, Niels Olsen, additional, Garcia Calich, Vera Lúcia, additional, Ramos, Rodrigo Nalio, additional, Nakaya, Helder I., additional, Rocha, Vanderson, additional, Giil, Lasse M., additional, Ochs, Hans D., additional, Schimke, Lena F., additional, de Souza, Mércia S.F., additional, Cuevas, Luis E., additional, Martins, Aline F., additional, and Cabral-Marques, Otavio, additional

Published
2023
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9. Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort study.

Author

Santos Dos Reis, Bάrbara Carvalho, Soares Faccion, Roberta, Anisio de Carvalho, Flavia Amendola, Cox Moore, Daniella Campelo Batalha, Chaves Zuma, Maria Celia, Plaça, Desirée Rodrigues, Salerno Filgueiras, Igor, Mathias Fonseca, Dennyson Leandro, Cabral-Marques, Otavio, Cesar Bonomo, Adriana, Savino, Wilson, de Paula Freitas, Flάvia Cristina, Faoro, Helisson, Passetti, Fabio, Rodrigues Robaina, Jaqueline, Caino de Oliveira, Felipe Rezende, Novaes Bellinat, Ana Paula, de Seixas Zeitel, Raquel, dos Santos Salú, Margarida, and Genuíno de Oliveira, Mariana Barros

Subjects
MULTISYSTEM inflammatory syndrome in children, GENETIC variation, INTERFERON gamma, EXOMES, MUCOCUTANEOUS lymph node syndrome, INTERFERON receptors, MULTISYSTEM inflammatory syndrome
Abstract

Introduction: Despite the existing data on the Multisystem Inflammatory Syndrome in Children (MIS-C), the factors that determine these patients evolution remain elusive. Answers may lie, at least in part, in genetics. It is currently under investigation that MIS-C patients may have an underlying innate error of immunity (IEI), whether of monogenic, digenic, or even oligogenic origin. Methods: To further investigate this hypothesis, 30 patients with MIS-C were submitted to whole exome sequencing. Results: Analyses of genes associated with MIS-C, MIS-A, severe covid-19, and Kawasaki disease identified twenty-nine patients with rare potentially damaging variants (50 variants were identified in 38 different genes), including those previously described in IFNA21 and IFIH1 genes, new variants in genes previously described in MIS-C patients (KMT2D, CFB, and PRF1), and variants in genes newly associated to MIS-C such as APOL1, TNFRSF13B, and G6PD. In addition, gene ontology enrichment pointed tothe involvement of thirteen major pathways, including complement system, hematopoiesis, immune system development, and type II interferon signaling, that were not yet reported in MIS-C. Discussion: These data strongly indicate that different gene families may favor MIS- C development. Larger cohort studies with healthy controls and other omics approaches, such as proteomics and RNAseq, will be precious to better understanding the disease dynamics. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID‐19 severity

Author

Prado, Caroline Aliane de Souza, primary, Fonseca, Dennyson Leandro M., additional, Singh, Youvika, additional, Filgueiras, Igor Salerno, additional, Baiocchi, Gabriela Crispim, additional, Plaça, Desirée Rodrigues, additional, Marques, Alexandre H. C., additional, Dantas‐Komatsu, Raquel Costa Silva, additional, Usuda, Júlia N., additional, Freire, Paula Paccielli, additional, Salgado, Ranieri Coelho, additional, Napoleao, Sarah Maria da Silva, additional, Ramos, Rodrigo Nalio, additional, Rocha, Vanderson, additional, Zhou, Guangyan, additional, Catar, Rusan, additional, Moll, Guido, additional, Camara, Niels Olsen Saraiva, additional, de Miranda, Gustavo Cabral, additional, Calich, Vera Lúcia Garcia, additional, Giil, Lasse M., additional, Mishra, Neha, additional, Tran, Florian, additional, Luchessi, Andre Ducati, additional, Nakaya, Helder I., additional, Ochs, Hans D., additional, Jurisica, Igor, additional, Schimke, Lena F., additional, and Cabral‐Marques, Otavio, additional

Published
2023
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11. SARS-CoV-2 infection induces the production of autoantibodies in severe COVID-19 patients in an age-dependent manner

Author

Fonseca, Dennyson Leandro M, primary, Filgueiras, Igor Salerno, additional, Marques, Alexandre HC, additional, Vojdani, Elroy, additional, Halpert, Gilad, additional, Ostrinski, Yuri, additional, Baiocchi, Gabriela Crispim, additional, Plaça, Desirée Rodrigues, additional, Freire, Paula P., additional, Pour, Shahab Zaki, additional, Moll, Guido, additional, Catar, Rusan, additional, Lavi, Yael Bublil, additional, Silverberg, Jonathan I., additional, Zimmerman, Jason, additional, de Miranda, Gustavo Cabral, additional, Carvalho, Robson F, additional, Khan, Taj Ali, additional, Heidecke, Harald, additional, Dalmolin, Rodrigo JS, additional, Luchessi, Andre Ducati, additional, Ochs, Hans D., additional, Schimke, Lena F., additional, Amital, Howard, additional, Riemekasten, Gabriela, additional, Zyskind, Israel, additional, Rosenberg, Avi Z, additional, Vojdani, Aristo, additional, Shoenfeld, Yehuda, additional, and Cabral-Marques, Otavio, additional

Published
2022
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12. Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity

Author

Sotzny, Franziska, primary, Filgueiras, Igor Salerno, additional, Kedor, Claudia, additional, Freitag, Helma, additional, Wittke, Kirsten, additional, Bauer, Sandra, additional, Sepúlveda, Nuno, additional, Mathias da Fonseca, Dennyson Leandro, additional, Baiocchi, Gabriela Crispim, additional, Marques, Alexandre H. C., additional, Kim, Myungjin, additional, Lange, Tanja, additional, Plaça, Desirée Rodrigues, additional, Luebber, Finn, additional, Paulus, Frieder M., additional, De Vito, Roberta, additional, Jurisica, Igor, additional, Schulze-Forster, Kai, additional, Paul, Friedemann, additional, Bellmann-Strobl, Judith, additional, Rust, Rebekka, additional, Hoppmann, Uta, additional, Shoenfeld, Yehuda, additional, Riemekasten, Gabriela, additional, Heidecke, Harald, additional, Cabral-Marques, Otavio, additional, and Scheibenbogen, Carmen, additional

Published
2022
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13. The relationship between autoantibodies targeting GPCRs and the renin-angiotensin system associates with COVID-19 severity

Author

Cabral-Marques, Otavio, primary, Halpert, Gilad, additional, Schimke, Lena F., additional, Ostrinski, Yuri, additional, Zyskind, Israel, additional, Lattin, Miriam T., additional, Tran, Florian, additional, Schreiber, Stefan, additional, Marques, Alexandre H.C., additional, Filgueiras, Igor Salerno, additional, Plaça, Desirée Rodrigues, additional, Baiocchi, Gabriela Crispim, additional, Freire, Paula Paccielli, additional, Fonseca, Dennyson Leandro M., additional, Humrich, Jens Y., additional, Lange, Tanja, additional, Müller, Antje, additional, Giil, Lasse M., additional, Graßhoff, Hanna, additional, Schumann, Anja, additional, Hackel, Alexander Maximilian, additional, Junker, Juliane, additional, Meyer, Carlotta, additional, Ochs, Hans D., additional, Lavi, Yael Bublil, additional, Schulze-Forster, Kai, additional, Silvergerg, Jonathan I., additional, Amital, Howard, additional, Zimmerman, Jason, additional, Heidecke, Harry, additional, Rosenberg, Avi Z, additional, Riemekasten, Gabriela, additional, and Shoenfeld, Yehuda, additional

Published
2021
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14. Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states

Author

Schimke, Lena F., primary, Marques, Alexandre H.C., additional, Baiocchi, Gabriela Crispim, additional, de Souza Prado, Caroline Aliane, additional, Fonseca, Dennyson Leandro M., additional, Freire, Paula Paccielli, additional, Plaça, Desirée Rodrigues, additional, Filgueiras, Igor Salerno, additional, Salgado, Ranieri Coelho, additional, Jansen-Marques, Gabriel, additional, Oliveira, Antonio Edson Rocha, additional, Peron, Jean Pierre Schatzmann, additional, Cabral-Miranda, Gustavo, additional, Barbuto, José Alexandre Marzagão, additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, Ochs, Hans D., additional, Condino-Neto, Antonio, additional, Overmyer, Katherine A., additional, Coon, Joshua J., additional, Balnis, Joseph, additional, Jaitovich, Ariel, additional, Schulte-Schrepping, Jonas, additional, Ulas, Thomas, additional, Schultze, Joachim L., additional, Nakaya, Helder I., additional, Jurisica, Igor, additional, and Cabral-Marques, Otávio, additional

Published
2021
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15. The network interplay of interferon and toll-like receptor signaling pathways in the anti-Candida immune response

Author

Salgado, Ranieri Coelho, primary, Fonseca, Dennyson Leandro M., additional, Marques, Alexandre H. C., additional, Napoleao, Sarah Maria da Silva, additional, França, Tábata Takahashi, additional, Akashi, Karen Tiemi, additional, Prado, Caroline Aliane de Souza, additional, Baiocchi, Gabriela Crispim, additional, Plaça, Desirée Rodrigues, additional, Jansen-Marques, Gabriel, additional, Filgueiras, Igor Salerno, additional, De Vito, Roberta, additional, Freire, Paula Paccielli, additional, de Miranda, Gustavo Cabral, additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, Ochs, Hans D., additional, Schimke, Lena F., additional, Jurisica, Igor, additional, Condino-Neto, Antonio, additional, and Cabral-Marques, Otavio, additional

Published
2021
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16. Specific immune-regulatory transcriptional signatures reveal sex and age differences in SARS-CoV-2 infected patients

Author

Freire, Paula Paccielli, primary, Marques, Alexandre H. C., additional, Baiocchi, Gabriela Crispim, additional, Schimke, Lena F., additional, Fonseca, Dennyson Leandro M., additional, Salgado, Ranieri Coelho, additional, Filgueiras, Igor Salerno, additional, da Silva Napoleao, Sarah Maria, additional, Plaça, Desirée Rodrigues, additional, Hirata, Thiago Dominguez Crespo, additional, El Khawanky, Nadia, additional, Giil, Lasse Melvaer, additional, de Miranda, Gustavo Cabral, additional, Carvalho, Robson Francisco, additional, de Souza Ferreira, Luis Carlos, additional, Condino-Neto, Antonio, additional, Nakaya, Helder Takashi Imoto, additional, Jurisica, Igor, additional, Ochs, Hans D., additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, and Cabral-Marques, Otavio, additional

Published
2020
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17. Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFV600E Mutation by Bioinformatics Integrative Analysis

Author

Goedert, Lucas, primary, Plaça, Jessica Rodrigues, additional, Fuziwara, Cesar Seigi, additional, Machado, Maiaro Cabral Rosa, additional, Plaça, Desirée Rodrigues, additional, Almeida, Palloma Porto, additional, Sanches, Talita Perez, additional, Santos, Jair Figueredo dos, additional, Corveloni, Amanda Cristina, additional, Pereira, Illy Enne Gomes, additional, de Castro, Marcela Motta, additional, Kimura, Edna Teruko, additional, Silva, Wilson Araújo, additional, and Espreafico, Enilza Maria, additional

Published
2017
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18. Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAF V600E Mutation by Bioinformatics Integrative Analysis.

Author

Goedert L, Plaça JR, Fuziwara CS, Machado MCR, Plaça DR, Almeida PP, Sanches TP, Santos JFD, Corveloni AC, Pereira IEG, de Castro MM, Kimura ET, Silva WA Jr, and Espreafico EM

Subjects
Carcinogenesis genetics, Carcinogenesis pathology, Cell Line, Tumor, Cluster Analysis, Down-Regulation genetics, Gene Expression Profiling, Humans, Reproducibility of Results, Up-Regulation genetics, Computational Biology methods, Gene Expression Regulation, Neoplastic, Mutation genetics, Proto-Oncogene Proteins B-raf genetics, RNA, Long Noncoding genetics, Thyroid Cancer, Papillary genetics
Abstract

Papillary Thyroid Cancer (PTC) is an endocrine malignancy in which BRAF V600E oncogenic mutation induces the most aggressive phenotype. In this way, considering that lncRNAs are arising as key players in oncogenesis, it is of high interest the identification of BRAF V600E -associated long noncoding RNAs, which can provide possible candidates for secondary mechanisms of BRAF-induced malignancy in PTC. In this study, we identified differentially expressed lncRNAs correlated with BRAF V600E in PTC and, also, extended the cohort of paired normal and PTC samples to more accurately identify differentially expressed lncRNAs between these conditions. Indirectly validated targets of the differentially expressed lncRNAs in PTC compared to matched normal samples demonstrated an involvement in surface receptors responsible for signal transduction and cell adhesion, as well as, regulation of cell death, proliferation and apoptosis. Targets of BRAF V600E -correlated lncRNAs are mainly involved in calcium signaling pathway, ECM-receptor interaction and MAPK pathway. In summary, our study provides candidate lncRNAs that can be either used for future studies related to diagnosis/prognosis or as targets for PTC management.

Published
2017
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