Search

In this work, an interesting application of phytochemistry for ethnopharmacological purposes was reported. In particular, the total phytochemical analysis of a single sample of Ajuga reptans L. (Lamiaceae) collected in Central Italy was carried out in order to provide a rationale for the use of this plant in folk medicine. This analysis was conducted on the volatile oil fraction by gas chromatography–mass spectroscopy (GC-MS) and on the polar one by means of classical column chromatography and nuclear magnetic resonance and MS. Thirty-nine volatile components were identified in the essential oil whereas 32 compounds were identified in the polar fraction. All of these are known to exert several beneficial medicinal activities and no potentially toxic compounds were identified such as the neo-clerodane diterpenoids, commonly evidenced in the entire genus. This study could provide a phytochemical rationale for the possible ethnopharmacological use of this specific species. [ABSTRACT FROM AUTHOR]

This article, titled "Cover Feature: Palladium Complexes of N-Methylcorroles," explores the chirality and coordination chemistry of N-alkylcorroles. The researchers have successfully separated enantiomeric pairs of monoalkylated regioisomers and determined their absolute configuration. The N-alkylation of corroles has a significant impact on their coordination chemistry, allowing for the preparation of divalent ion complexes like PdII. The photophysical properties of N-alkylcorroles show promise for future applications as photosensitizers and catalysts. The full research article provides more detailed information on this topic. [Extracted from the article]

The reaction of Zn ions with β-octaalkylcorroles leads to the air oxidation of the macrocycle, with the formation of a mixture of 5- and 10-oxocorroles. Spectroscopic characterization confirms the antiaromatic character of these macrocycles. A simple synthetic protocol opens the way for more detailed studies of oxocorrole chemistry.

Alkylation of one of the inner-core nitrogen atoms is one possible approach to obtain dianionic corrole ligands, suitable for the coordination of divalent metal ions, such as Pd II . Inner-core N-methylation can be obtained by treating the corrole with CH 3 I, but the reaction conditions should be optimized to limit the formation of the dimethylated derivative. Two regioisomers, the N-21 and the N-22 methyl derivatives are obtained from the reaction, with the first product achieved in a higher amount. Structural characterization of the reaction products evidenced the distortion induced by the introduction of the methyl groups; the N-methylcorroles are chiral compounds, and the enantiomers were separated by chromatography, with their absolute configuration assigned by ECD computation. Palladium insertion was achieved in the case of monosubstituted corroles, but not with the dimethylated macrocycle; X-ray characterization of the complexes showed the distortion of the macrocycles. The Pd complexes do not show luminescence emission, but are able to produce singlet oxygen upon irradiation. The Pd II complexes were also inserted in human serum albumin (HSA) and dispersed in water; in this case, the protein protects the corroles from photobleaching, and a switch from the type II to the type I mechanism in reactive oxygen species (ROS) production is observed., (© 2023 Wiley-VCH GmbH.)