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BackgroundTransformative experiences (TEs) have been conceptualized in many ways, contexts, magnitudes, and durations, but at their heart, they entail some manner of adjustment, which contributes to changing individuals’ worldviews, actions, views of others and/or their own feelings, personality, and identity. Among the many elicitors identified as being able to foster TEs, an emerging body of literature has suggested that TEs might be prevalent in aesthetics or emerged from encounters with human art. Beyond denoting ordinary moments characterizing our daily lives, art and aesthetics could occasionally represent profound changes, causing shifts in our perceptions, beliefs and understanding of the world. However, in the realm of psychological inquiry, the extent to which art and aesthetics can be considered potential catalysts for transformation remains a topic of debate. Furthermore, a comprehensive identification of the key psychological components that contribute to the process of transformation before, during, and after aesthetic engagement is still missing.AimsThis systematic review endeavors to address these gaps by synthesizing literature on aesthetic transformative experiences either from the field of psychology or explicitly delving into the psychological impact of transformative experiences within the realm of art and aesthetics. It encompasses both theoretical and empirical papers to determine key aspects and psychological components that characterize TEs.MethodsTwo major electronic databases were systematically searched. The review was conducted in accordance with Liberati et al. (2009) and PRISMA guidelines. All stages of the review were conducted independently by three researchers, and the protocol was published on PROSPERO (Registration no.: CRD42022298655).ResultsAlthough 39.440 studies were identified, only 23 peer-reviewed articles were included in this review, as most studies did not explicitly delve into the long-lasting psychological impact of art and aesthetics.DiscussionThe results confirm the potential of art and aesthetics as elicitors of transformation regardless of the type of artwork and the usage context. Moreover, it also identifies some psychological components necessary for transformation in the realm of art and aesthetics, including facilitating conditions/pre-expectations, cognitive discrepancy, epiphany and insight, and several after-effects on the recipient.ConclusionThe review aids in refining and enriching the concept of transformative experience, paving the way for further research and applications in various fields, including not only psychology but also education and therapeutic interventions.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022298655.

Abstract Over the last two decades, awe has attracted the attention of an increasing number of researchers. The use of virtual reality has been identified as one of the most effective techniques for eliciting awe, in addition to more personalized methods for inducing emotion, such as autobiographical recall. However, previous measures of awe were unable to uncover the hidden structure of this experience. Awe experience scale (AWE-S) has been validated as a comprehensive measure of contingent awe in English, providing new opportunities for analysis. In this two-phases study, we investigated whether the latent structure of the experience of awe evoked by the autobiographical recall technique (Study 1) overlapped with that induced by exposing participants to a validated virtual reality awe-eliciting training (Study 2). The original English AWE-S structure held both in autobiographical recall induction and virtual reality-based elicitation. Despite evidence of overlap between English and Italian structures, low correlations were found between Italian trait measures used to test the concurrent validity of the AWE-S in the Italian sample and AWE-S state dimensions. This study highlights cultural differences in awe experience, trait, and state variations, and provides new insights into the standardized induction of this emotion through simulated environments.

Abstract Environmental pollutants from different chemical families may reach the gut microbiome, where they can be metabolized and transformed. However, how our gut symbionts respond to the exposure to environmental pollution is still underexplored. In this observational, cohort study, we aim to investigate the influence of environmental pollution on the gut microbiome composition and potential activity by shotgun metagenomics. We select as a case study a population living in a highly polluted area in Campania region (Southern Italy), proposed as an ideal field for exposomic studies and we compare the fecal microbiome of 359 subjects living in areas with high, medium and low environmental pollution. We highlight changes in gut microbiome composition and functionality that were driven by pollution exposure. Subjects from highly polluted areas show higher blood concentrations of dioxin and heavy metals, as well as an increase in microbial genes related to degradation and/or resistance to these molecules. Here we demonstrate the dramatic effect that environmental xenobiotics have on gut microbial communities, shaping their composition and boosting the selection of strains with degrading capacity. The gut microbiome can be considered as a pivotal player in the environment-health interaction that may contribute to detoxifying toxic compounds and should be taken into account when developing risk assessment models. The study was registered at ClinicalTrials.gov with the identifier NCT05976126.

The purpose of this pilot study was to evaluate the possible effect of two natural enzymes, bromelain and escin (test), in the treatment of post-operative sequelae after open flap implant placement in the posterior area compared with painkiller medications (control). Fourteen patients were enrolled and randomly assigned to test and control groups. Bromelain and escin were administered in the test group, and a placebo was administered in the control group. Oedema, pain, and trismus were evaluated at the baseline, 2 and 7 days after surgery. Trismus was assessed using an analogue method; oedema was assessed using analogue and digital methods, while pain was reported using a numerical rating scale (NRS). Descriptive analysis and not paired-test were performed. The analogue data for oedema for the test and control groups was 10.73 ± 0.77 cm and 10.67 ± 0.74 cm (p-value baseline–7 days = 0.1004) at 7 days post-surgery. The digital analysis showed at 7 days post-surgery 0.41 ± 0.24 mm for the test group and 0.56 ± 0.52 mm for the control group (p-value baseline–7 days = 0.3140). Pain (NRS 0–10) was higher for the test group at each time point. Trismus was accentuated in the test group at each time point after the surgery. Statistically significant differences were found for the analogue oedema evaluation between baseline and day 2, for trismus in both baseline and day 2 and baseline and day 7 comparison, and for paracetamol tablets intake at day 2. Further observations of more patients are needed.

Abstract Background Virtual Reality (VR) has already emerged as an effective instrument for simulating realistic interactions, across various domains. In the field of User Experience (UX), VR has been used to create prototypes of real-world products. Here, the question is to what extent the users’ experience of a virtual prototype can be equivalent to that of its real counterpart (the real product). This issue particularly concerns the perceptual, cognitive and affective dimensions of users’ experiences. Methods This exploratory study aims to address this issue by comparing the users’ experience of a well-known product, i.e., the Graziella bicycle, presented either in Sumerian or Sansar VR platform, or in a physical setting. Participants’ Emotional Engagement, Sense of Presence, Immersion, and Perceived Product Quality were evaluated after being exposed to the product in all conditions (i.e., Sumerian, Sansar and Physical). Results The findings indicated significantly higher levels of Engagement and Positive Affect in the virtual experiences when compared to their real-world counterparts. Additionally, the sole notable distinction among the VR platforms was observed in terms of Realism. Conclusions This study suggests the feasibility and potential of immersive VR environments as UX evaluation tools and underscores their effectiveness in replicating genuine real-world experiences.

Abstract The assessment of groundwater vulnerability to pollution is becoming even more important all over the world due to the increase of impacts of human activities on groundwater resources and the related risks to the human health, economics, and the environment. Owing to the variability of methods known for estimating groundwater vulnerability, basically depending on hydrogeological parameters considered and the scale of analysis, the comparison of results of different methods appears straightforward for identifying the best approach in a given hydrogeological condition and reference scale. In such a view, this work attempts to assess the groundwater vulnerability of the Terminio Mt. karst aquifer, by applying four different groundwater vulnerability methods, index-based, and comparing results in order to identify the best performing one in karst environments. The study aquifer, located in the Picentini Mts Regional Park (Campania region, southern Italy) represents a strategic drinking water resource since Roman times and hosts massive groundwater resources which outflow mainly from tapped basal and subordinately perched springs. The peculiar characters of the study karst aquifer, which favour direct infiltration and groundwater recharge processes, as well as the occurrence of industrial, agricultural and grazing activities, make it very vulnerable to groundwater pollution, thus requiring a proper and careful territorial management. Beside the most frequently and generally used methods for assessing groundwater vulnerability, such as the DRASTIC and SINTACS, also DAC and COP methods specifically designed for karst aquifers were applied and mutually compared. Results of SINTACS, DRASTIC and DAC methods show groundwater vulnerability maps of the Terminio Mt. karst aquifer as chiefly characterized by two classes of intrinsic groundwater vulnerability, varying between the medium and high degrees. Furthermore, high and extremely high values of groundwater vulnerability were found in areas controlled by the shallow depth of the water-table. Instead, the COP method resulted as the most effective in identifying the endorheic areas and the related karst morphologies as very high groundwater vulnerability zones, therefore the most suitable in capturing specific hydrogeological features of karst areas that control groundwater pollution and vulnerability. Results obtained will support decision tools aimed at the land use planning and protection of karst aquifers from pollution in karst areas.

A myriad of factors influence young people’s vulnerability and the likelihood of becoming NEET. Moreover, the share of young NEETs in European countries is very high. Institutional and governmental initiatives aiming to promote the inclusion of young people in the labour market are of paramount importance. However, the socio-economic conditions and the level of vulnerability alongside other socio-demographic characteristics are likely to influence the extent to which young people ultimately engage with such programmes. The current study ascertains whether previous experience of informal work increases young people’s propensity to participate in programmes offered by public employment services, such as the Youth Guarantee Programme. Indeed, we hypothesise that the experience of working without a contract makes young people more aware and concerned about the risk of remaining trapped in a spiral of vulnerable jobs. To test this, we used data from a survey of 4,273 NEETs and focused on Italy, Portugal, and Spain. The study’s findings contribute to a better understanding of the relationship between past experience in the informal economy and engagement with the Youth Guarantee. Besides contributing to the literature, the study can also contribute to policy making and practitioners’ assessment of the relative efficacy of Youth Guarantee initiatives among different subgroups of young NEET and tailor the interventions accordingly. In other words, the outcomes of this study should signal to governments that greater efforts should be made to implement initiatives reaching out to young people, as well as acting to reduce the precariousness in job contracts, which negatively impacts their quality of life.

Subjective well-being is of paramount importance when support is offered to young individuals seeking employment and social inclusion in general. The present study looks at different dimensions of youth well-being and the growing demands for skills to enable labour market integration. Based on survey data, this article examines the relationships between the role of public employment services in providing support and their impact on the subjective well-being of youth. Specifically, 1,275 not in education, employment, or training (NEET) rural youths from Italy, Portugal, and Spain participated in the survey. Drawing upon Bronfenbrenner’s bioecological model, the current study sets up a model which includes different factors at the micro-, meso-, exo-, and macro-system levels. The results show that non-urban NEETs’ subjective well-being is associated positively with public employment services availability, while the relationship with public employment services interaction and public employment services support is non-significant. A positive and significant relationship emerged also with self-efficacy and social support. Some recommendations for policymakers are discussed.

On 27 February 2021, the Food and Drug Administration(FDA) authorized the administration of the adenovirus-based Ad26.COV2-S vaccine (J&J-Janssen) for the prevention of COVID-19, a viral pandemic that, to date, has killed more than 5.5 million people. Performed during the early phase of the COVID-19 4th wave, this retrospective observational study aims to report the computerized tomography (CT) findings and intensive care unit admission rates of Ad26.COV2-S-vaccinated vs. unvaccinated COVID-19 patients. From the 1st to the 23rd of December 2021, all confirmed COVID-19 patients that had been subjected to chest non-contrast CT scan analysis were enrolled in the study. These were divided into Ad26.COV2.S-vaccinated (group 1) and unvaccinated patients (group 2). The RSNA severity score was calculated for each patient and correlated to CT findings and type of admission to a healthcare setting after CT—i.e., home care, ordinary hospitalization, sub-intensive care, and intensive care. Descriptive and inference statistical analyses were performed by comparing the data from the two groups. Data from a total of 71 patients were collected: 10 patients in group 1 (4M, 6F, mean age 63.5 years, SD ± 4.2) and 61 patients in group 2 (32M, 29F, mean age 64.7 years, SD ± 3.7). Statistical analysis showed lower values of RSNA severity in group 1 compared to group 2 (mean value 14.1 vs. 15.7, p = 0.009, respectively). Furthermore, vaccinated patients were less frequently admitted to both sub-intensive and high-intensive care units than group 2, with an odds ratio of 0.45 [95%CI (0.01; 3.92)]. Ad26.COV2.S vaccination protects from severe COVID-19 based on CT severity scores. As a result, Ad26.COV2.S-vaccinated COVID-19 patients are more frequently admitted to home in comparison with unvaccinated patients.

Abstract Background In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal competition, biofilm formation, adherence to epithelial cells, intracellular survival and vacuolar escape. These diverse functions could be attributed to distinct domains of secreted HrpA. Methods A yeast two-hybrid screening, in vitro pull-down assay and immunofluorescence microscopy experiments were used to investigate the interaction between HrpA and the dynein light-chain, Tctex-type 1 (DYNLT1). In silico modeling was used to analyze HrpA structure. Western blot analysis was used to investigate apoptotic and pyroptotic markers. Results The HrpA carboxy-terminal region acts as a manganese-dependent cell lysin, while the results of a yeast two-hybrid screening demonstrated that the HrpA middle region has the ability to bind the dynein light-chain, Tctex-type 1 (DYNLT1). This interaction was confirmed by in vitro pull-down assay and immunofluorescence microscopy experiments showing co-localization of N. meningitidis with DYNLT1 in infected epithelial cells. In silico modeling revealed that the HrpA-M interface interacting with the DYNLT1 has similarity with capsid proteins of neurotropic viruses that interact with the DYNLT1. Indeed, we found that HrpA plays a key role in infection of and meningococcal trafficking within neuronal cells, and is implicated in the modulation of the balance between apoptosis and pyroptosis. Conclusions Our findings revealed that N. meningitidis is able to effectively infect and survive in neuronal cells, and that this ability is dependent on HrpA, which establishes a direct protein–protein interaction with DYNLTI in these cells, suggesting that the HrpA interaction with dynein could be fundamental for N. meningitidis spreading inside the neurons. Moreover, we found that the balance between apoptotic and pyroptotic pathways is heavily affected by HrpA.

Drilling for implant site preparation generates heat, which can cause bone necrosis if temperatures exceed 47 °C for over a minute. Factors influencing heat include drill size, speed, pressure, irrigation, and tool wear. Frequent drill replacement is essential, as wear from repeated use and sterilization affects performance. This study compared three pilot drills with similar designs from different manufacturers, testing each on pig ribs for 15 perforations after 15 sterilization cycles. Researchers measured temperature increase, drilling time, and surface wear. Results showed that drill no. 1 generated more heat than drills no. 2 and no. 3, though none reached critical temperatures. Drill no. 2 took the longest to reach the desired depth and displayed the most deformation. Findings highlight the importance of adhering to the recommended operational limits, suggesting that drills should be replaced after 15 cycles to ensure efficacy and patient safety. [ABSTRACT FROM AUTHOR]

Background: Transformative experiences (TEs) have been conceptualized in many ways, contexts, magnitudes, and durations, but at their heart, they entail some manner of adjustment, which contributes to changing individuals' worldviews, actions, views of others and/or their own feelings, personality, and identity. Among the many elicitors identified as being able to foster TEs, an emerging body of literature has suggested that TEs might be prevalent in aesthetics or emerged from encounters with human art. Beyond denoting ordinary moments characterizing our daily lives, art and aesthetics could occasionally represent profound changes, causing shifts in our perceptions, beliefs and understanding of the world. However, in the realm of psychological inquiry, the extent to which art and aesthetics can be considered potential catalysts for transformation remains a topic of debate. Furthermore, a comprehensive identification of the key psychological components that contribute to the process of transformation before, during, and after aesthetic engagement is still missing. Aims: This systematic review endeavors to address these gaps by synthesizing literature on aesthetic transformative experiences either from the field of psychology or explicitly delving into the psychological impact of transformative experiences within the realm of art and aesthetics. It encompasses both theoretical and empirical papers to determine key aspects and psychological components that characterize TEs. Methods: Two major electronic databases were systematically searched. The review was conducted in accordance with Liberati et al. (2009) and PRISMA guidelines. All stages of the review were conducted independently by three researchers, and the protocol was published on PROSPERO (Registration no.: CRD42022298655). Results: Although 39.440 studies were identified, only 23 peer-reviewed articles were included in this review, as most studies did not explicitly delve into the long-lasting psychological impact of art and aesthetics. Discussion: The results confirm the potential of art and aesthetics as elicitors of transformation regardless of the type of artwork and the usage context. Moreover, it also identifies some psychological components necessary for transformation in the realm of art and aesthetics, including facilitating conditions/pre-expectations, cognitive discrepancy, epiphany and insight, and several after-effects on the recipient. Conclusion: The review aids in refining and enriching the concept of transformative experience, paving the way for further research and applications in various fields, including not only psychology but also education and therapeutic interventions. Systematic review registration: https://www.crd.york.ac.uk/prospero/ , identifier CRD42022298655. [ABSTRACT FROM AUTHOR]

Background: Bulk milk samples from 69 dairy buffalo farms of the Campania Region, Italy were drawn for the determination of 20 selected elements by ICP-MS. The main goal was to ascertain how the agricultural soil geo-chemistry could influence the milk pattern with respect to feeding practices. Methods: Local forages (N = 207) and groundwater (N = 486) were analyzed too to recover the feeding-to-milk carry-over rates (COR) of selected elements and identify the main contributors to milk contamination. Left censored data >10% limited to 11 elements (Mn, As, Se, Sr, Zn, Cr, Fe, Co, Ni, Cu, and V) the multivariate system approach based on cluster and factor analysis. Results: We identified 8/11 elements - Sr, Mn, Zn, Co, Se, Cr, Fe, and V - explaining the main quote of variation observed among farms milk pattern. In particular, Co resulted as discriminant for specific villages of the Salerno Province. On median values, cereals (34%) and feed supplement (31%) represented the main contributors to Cr intake; for V, hay (46%) and water (42%); for Fe, water (46%); for Se, Co and Zn, mineral supplements (67; 73; 82%); for Sr, hay (71%), for Mn, mineral supplements (36%) and water (30%). Median CORs rates (%) were the following: Se and Cr: 40; V: 13; Mn: 5.2; Sr: 4.7; Zn: 3.7; Co: 3.4; Fe: 1.6; respectively. Conclusion: The factor analysis could trace the geographical origin of buffalo milk at farm level, according to similar management practices, partially irrespective of the municipality/province level.