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209 results on '"Pitzurra, L."'

2. Prospective multicentre study on azole resistance in Aspergillus isolates from surveillance cultures in haematological patients in Italy

Author

Prigitano, A., Esposto, M.C., Grancini, A., Passera, M., Paolucci, M., Stanzani, M., Sartor, A., Candoni, A., Pitzurra, L., Innocenti, P., Micozzi, A., Cascio, G. Lo, Delia, M., Mosca, A., Mikulska, M., Ossi, C., Fontana, C., Pizzolante, M., Gelmi, M., Cavanna, C., Lallitto, F., Amato, G., Vella, A., Pagano, L., Bandettini, R., De Lorenzis, G., Cogliati, M., Romanò, L., and Tortorano, A.

Published
2020
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6. SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients

Author

Montagna, M. T., Lovero, G., Coretti, C., Martinelli, D., Delia, M., De Giglio, O., Caira, M., Puntillo, F., D’Antonio, D., Venditti, M., Sambri, V., Di Bernardo, F., Barbui, A., Lo Cascio, G., Concia, E., Mikulska, M., Viscoli, C., Maximova, N., Candoni, A., Oliveri, S., Lombardi, G., Pitzurra, L., Sanguinetti, M., Masciari, R., Santantonio, T., Andreoni, S., Barchiesi, F., Pecile, P., Farina, C., Viale, P., Specchia, G., Caggiano, G., and Pagano, L.

Published
2014
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8. The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma

Author

Carvalho, A, Cunha, C, Almeida, A J, Osório, N S, Saraiva, M, Teixeira-Coelho, M, Pedreiro, S, Torrado, E, Domingues, N, Gomes-Alves, A G, Marques, A, Lacerda, J F, da Silva, M G, Gomes, M, Pinto, A C, Torres, F, Rendeiro, P, Tavares, P, Di Ianni, M, Medeiros, R, Heutink, P, Bracci, P M, Conde, L, Ludovico, P, Pedrosa, J, Maciel, P, Pitzurra, L, Aversa, F, Marques, H, Paiva, A, Skibola, C F, Romani, L, Castro, A G, and Rodrigues, F

Published
2012
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12. Prospective multicentre study on azole resistance in Aspergillus isolates from surveillance cultures in haematological patients in Italy

Author

Prigitano, A, Esposto, M C, Grancini, A, Passera, M, Paolucci, M, Stanzani, M, Sartor, A, Candoni, A, Pitzurra, L, Innocenti, P, Micozzi, A, Cascio, G Lo, Delia, M, Mosca, A, Mikulska, M, Ossi, C, Fontana, C, Pizzolante, M, Gelmi, M, Cavanna, C, Lallitto, F, Amato, G, Vella, Antonietta, Pagano, Livio, Bandettini, R, De Lorenzis, G, Cogliati, M, Romanò, L, Tortorano, A, Vella, A, Pagano, L (ORCID:0000-0001-8287-928X), Prigitano, A, Esposto, M C, Grancini, A, Passera, M, Paolucci, M, Stanzani, M, Sartor, A, Candoni, A, Pitzurra, L, Innocenti, P, Micozzi, A, Cascio, G Lo, Delia, M, Mosca, A, Mikulska, M, Ossi, C, Fontana, C, Pizzolante, M, Gelmi, M, Cavanna, C, Lallitto, F, Amato, G, Vella, Antonietta, Pagano, Livio, Bandettini, R, De Lorenzis, G, Cogliati, M, Romanò, L, Tortorano, A, Vella, A, and Pagano, L (ORCID:0000-0001-8287-928X)

Abstract

Objectives: This study was conducted to assess the prevalence of azole resistance in Aspergillus isolates from patients with haematological malignancies or who were undergoing haematopoietic stem cell transplantation and to identify the molecular mechanism of resistance. Methods: In this 28-month prospective study involving 18 Italian centres, Aspergillus isolates from surveillance cultures were collected and screened for azole resistance, and mutations in the cyp51A gene were identified. Resistant isolates were genotyped by microsatellite analysis, and the allelic profiles were compared with those of resistant environmental and clinical isolates from the same geographical area that had been previously genotyped. Results: There were 292 Aspergillus isolates collected from 228 patients. The isolates belonged mainly to the section Fumigati (45.9%), Nigri (20.9%), Flavi (16.8%) and Terrei (4.8%). Three isolates showed itraconazole resistance: Aspergillus fumigatus sensu stricto, Aspergillus lentulus (section Fumigati) and Aspergillus awamori (section Nigri). The itraconazole resistance rates were 1% and 1.48% considering all Aspergillus spp. isolates and the Aspergillus section Fumigati, respectively. The prevalence of azole resistance among all the patients was 1.3%. Among patients harbouring A. fumigatus sensu stricto isolates, the resistance rate was 0.79%. The A. fumigatus isolate, with the TR34/L98H mutation, was genotypically distant from the environmental and clinical strains previously genotyped. Conclusions: In this study, the Aspergillus azole resistance rate was 1% (3/292). In addition to A. fumigatus sensu stricto, A. lentulus and A. awamori azole-resistant isolates were identified. Therefore, it is important have a correct identification at the species level to address a rapid therapy better, quickly understand the shift towards cryptic species and have an updated knowledge of the local epidemiology.

Published
2020

18. Prospective multicentre study on azole resistance in Aspergillusisolates from surveillance cultures in haematological patients in Italy

Author

Prigitano, A., Esposto, M.C., Grancini, A., Passera, M., Paolucci, M., Stanzani, M., Sartor, A., Candoni, A., Pitzurra, L., Innocenti, P., Micozzi, A., Cascio, G. Lo, Delia, M., Mosca, A., Mikulska, M., Ossi, C., Fontana, C., Pizzolante, M., Gelmi, M., Cavanna, C., Lallitto, F., Amato, G., Vella, A., Pagano, L., Bandettini, R., De Lorenzis, G., Cogliati, M., Romanò, L., and Tortorano, A.

Abstract

•The prevalence of azole resistance was 1.3% in haematological patients.•The itraconazole resistance rate was 1.48% considering Aspergillus,section Fumigati.•Two cryptic azole-resistant species were identified, Aspergillus lentulusand Aspergillus awamori.

Published
2020
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21. Looking for Candida nivariensis and C. bracarensis among a large Italian collection of C. glabrata isolates: Results of the FIMUA working group

Author

Esposto, M. C, Prigitano, A, Romeo, O, Criseo, G, Trovato, L, Tullio, V, Fadda, M. E, Tortorano, A. M, FIMUA Working Group, Ossi, C, Grancini, A, Grandesso, S, Sanguinetti, M, Montagna, Mt, Manso, E, Deiana, Ml, Pitzurra, L, Mazzoli, S, Tavanti, A, Venturelli, C, LO CASCIO, Giuliana, and Innocenti, P.

Subjects
Adult, Male, Adolescent, Genes, Fungal, Candida bracarensis, Candida glabrata, Young Adult, 80 and over, 5.8S, Humans, Child, Preschool, Mycological Typing Techniques, Candida nivariensis, Aged, Aged, 80 and over, Candida, Candidiasis, Child, Preschool, Female, Infant, Infant, Newborn, Italy, Middle Aged, Phenotype, RNA, Fungal, RNA, Ribosomal, 5.8S, 2708, Infectious Diseases, Ribosomal, Newborn, Fungal, Genes, RNA
Abstract

Two recently described pathogenic Candida species, C. nivariensis and C. bracarensis, share many phenotypic characteristics with C. glabrata and are easily misidentified as such. The aim of this study was to determine the occurrence of these cryptic species in Italy. One thousand yeast isolates collected in 14 Italian regions and identified as C. glabrata by phenotypic and biochemical methods were included in this study: 928 were screened on CHROMagar and 72 were analysed by a multiplex PCR. None of these cryptic species was identified despite the nationwide distribution and the variety of biological origin of the isolates.

Published
2013

23. SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients

Author

Montagna, Mt, Lovero, G, Coretti, C, Martinelli, D, Delia, M, De Giglio, O, Caira, M, Puntillo, F, D'Antonio, D, Venditti, M, Sambri, V, Di Bernardo, F, Barbui, A, Lo Cascio, G, Concia, E, Mikulska, M, Viscoli, C, Maximova, N, Candoni, A, Oliveri, S, Lombardi, G, Pitzurra, L, Sanguinetti, Maurizio, Masciari, R, Santantonio, T, Andreoni, S, Barchiesi, F, Pecile, P, Farina, C, Viale, P, Specchia, G, Caggiano, G, Pagano, Livio, Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Pagano, Livio (ORCID:0000-0001-8287-928X), Montagna, Mt, Lovero, G, Coretti, C, Martinelli, D, Delia, M, De Giglio, O, Caira, M, Puntillo, F, D'Antonio, D, Venditti, M, Sambri, V, Di Bernardo, F, Barbui, A, Lo Cascio, G, Concia, E, Mikulska, M, Viscoli, C, Maximova, N, Candoni, A, Oliveri, S, Lombardi, G, Pitzurra, L, Sanguinetti, Maurizio, Masciari, R, Santantonio, T, Andreoni, S, Barchiesi, F, Pecile, P, Farina, C, Viale, P, Specchia, G, Caggiano, G, Pagano, Livio, Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), and Pagano, Livio (ORCID:0000-0001-8287-928X)

Abstract

We compared the risk factors, the diagnostic tools and the outcome of filamentous fungal infections (FFIs) in hematological patients (HAEs) and non-hematological patients (non-HAEs).

Published
2014

24. The EUREKA Projekt MEMFOODIN. Microbial environmental monitoring in the food industry

Author

Pitzurra, O., Hennlich, W., Pasquarella, C., Gantenbein-Demarchi, C., Ortaggi, G., Pitzurra, L., Ruddy, T., Savino, A., and Publica

Abstract

From March 1999 to May 2006 various research institutes, technology providers and service providers (40 partners in over six European countries) - were involved in the EUREKA project "Microbial Environmental Monitoring in the Food Industry" (MEMFOODIN). This project was aimed at supporting microbial environmental "self-control" by standardising a rapid, reliable and easy-to-use method of microbial environmental control applicalbe to any food-industry sector prone to bio risk, verifying the applicability of new methodologies to the development of microbial "self-control" to upgrade food-industry quality control management and developing new procedures that would cut the cost of certification. This article explains the importance of microbial environmental control and self-control inspections (basic prerequisites for the HACCP as underlined also by the new ISO 22000), describes the MEMFOODIN project, and summarises the main objectives achieved.

Published
2007

25. In vitro activity of voriconazole and other antifungal agents against clinical isolates of Candida glabrata and Candida krusei

Author

Drago, M., Scaltrito, M. M., Morace, G., Manso, E., Paladini, C., Montagna, M. T., Tato’, D., Goglio, A., Farina, C., Nanetti, A., Morelli, S., Sanna, M., Podda, R., Porcu, P. P., Oliveri, S., Buscema, G., Nicoletti, P. L., Pecile, P., Schito, G. C., Soro, O., Viviani, M. A., Tortorano, A. M., Amato, G., Piccirillo, M. M., Cione, P., Cuccurullo, S., Andreoni, S., Fanello, M. R., Menozzi, M., DI STEFANO, E., Polonelli, L., Conti, S., Fanti, F., Cavanna, P. MARONE C., Bistoni, F., Mencacci, A., Pitzurra, L., Sergi, D., Barbaro, P., Fadda, G., Sanguinetti, M., Rigoli, R., Niero, M., Lombardi, G. L., Coli’, A., Fontana, Roberta, and LO CASCIO, Giuliana

Subjects
Microbiology (medical), Antifungal Agents, Candida glabrata, Candida krusei, Sensititre YeastOne-3 system, Itraconazole, Microbial Sensitivity Tests, Pharmacology, In Vitro Techniques, Sensitivity and Specificity, Sampling Studies, Flucytosine, Microbiology, Drug Resistance, Fungal, Amphotericin B, medicine, Humans, Candida, chemistry.chemical_classification, Voriconazole, biology, Candidiasis, General Medicine, biochemical phenomena, metabolism, and nutrition, Triazoles, bacterial infections and mycoses, biology.organism_classification, stomatognathic diseases, Infectious Diseases, Pyrimidines, chemistry, Italy, Azole, Fluconazole, medicine.drug
Abstract

The antifungal susceptibility of 309 Candida glabrata and 63 Candida krusei clinical isolates was tested via the Sensititre YeastOne-3 system (Trek Diagnostic Systems, East Grinstead, UK) to compare the in vitro activity of voriconazole with that of five other antifungal agents (amphotericin B, fluconazole, itraconazole, ketoconazole, and flucytosine). Voriconazole was highly active (MIC90, 0.5 microg/ml) against isolates of both species, including those for which the MICs of itraconazole and fluconazole were high (MIC90s of itraconazole, 2 microg/ml for C. glabrata and 0.5 microg/ml for C. krusei; MIC90s of fluconazole, 32 microg/ml for C. glabrata and 64 microg/ml for C. krusei). Ketoconazole MIC90 values for both species were identical to those of voriconazole. The MIC90 of amphotericin B was similar for both species (0.125 microg/ml for C. glabrata and 0.25 microg/ml for C. krusei). As expected, flucytosine was only moderately active against C. krusei isolates (MIC90, 16 microg/ml) but was highly active against C. glabrata isolates (MIC90, 0.03 microg/ml). Potential cross-resistance within the azole class was noted for some strains of C. glabrata (5.5%) that presented high MIC values for all the azoles tested. In order to consider voriconazole a viable alternative to other triazoles for the treatment of infections caused by Candida species, susceptibility testing of all clinically significant isolates of C. glabrata and C. krusei is recommended because of the potential for azole cross-resistance. The Sensititre YeastOne-3 seems to be a suitable commercial tool for this purpose.

Published
2005

26. Voriconazole activity against clinical yeast isolates: a multicentre Italian study

Author

Morace, G, Polonelli, L., Amato, G., Piccirillo, M., Belli, C. M. C., Andreoni, S., Fanello, R., Barbaro, P., Petraroli, C., Bistoni, F., Mencacci, A., Pitzurra, L., Cione, P., Fadda, G., Sanguinetti, M., Fontana, Roberta, LO CASCIO, Giuliana, Goglio, A., Farina, C., Lombardi, G., Coli', A., Manso, E., Paladini, C., Marone, P., Cavanna, C., Menozzi, M., DI STEFANO, E., Montagna, M. T., Napoli, C., Tato', D., Nanatti, A., Nicoletti, P. L., Pecile, P., Oliveri, S., Buscema, G., Conti, S., Fanti, F., Rigoli, R., Niero, M., Sanna, M., Podda, R., Porcu, P. P., Schito, G. C., Soro, O., Viviani, M. A., Tortorano, A. M., LA FACE, S., and Mancuso, I.

Subjects
Microbiology (medical), Antifungal Agents, Comparative methods, Voriconazole, Yeast susceptibility testing, Drug resistance, Microbial Sensitivity Tests, Saccharomyces cerevisiae, Biology, Microbiology, Trichosporon, Drug Resistance, Fungal, Outpatients, medicine, Humans, Pharmacology (medical), Agar diffusion test, Candida albicans, Diffusion methods, Etest, Candida, Inpatients, Broth microdilution, Fungi, General Medicine, Triazoles, bacterial infections and mycoses, biology.organism_classification, Settore MED/07 - Microbiologia e Microbiologia Clinica, Geotrichum, Yeast, Infectious Diseases, Pyrimidines, Italy, Mycoses, Cryptococcus neoformans, medicine.drug
Abstract

The activity of voriconazole was tested in vitro against 1996 clinical yeast isolates collected in 20 Italian microbiology laboratories. Voriconazole susceptibility testing was carried out with the broth microdilution (NCCLS M27-A2), Etest and disk diffusion methods. The minimum inhibitory concentrations at which 90% of the isolates were inhibited (MIC90) obtained with the NCCLS method were 0.03 mg/L for Candida albicans, 0.5 mg/L for Candida non-albicans and 0.25 mg/L for other genera; those obtained with Etesting were, respectively, 0.032 mg/L, 0.125 mg/L and 0.125 mg/L. With the disk diffusion method, the majority of isolates (92.3%) showed inhibition zone diameters between 21 mm and 40 mm. Using a tentative MIC cut-off of 1 mg/L as indicative of in vitro susceptibility, 98.1% of the isolates tested in our study would be classified as susceptible, and only 28 (1.4%) of the isolates, with MICs higher than 2 mg/L, would be classified as resistant to the drug. Our findings confirm the broad-spectrum in vitro activity of voriconazole against yeasts, including Candida species that are generally less susceptible to other azoles.

Published
2005

29. SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients

Author

Montagna, Mt, Lovero, G, Coretti, C, Martinelli, D, Delia, M, De Giglio, O, Caira, M, Puntillo, F, D'Antonio, D, Venditti, M, Sambri, V, Di Bernardo, F, Barbui, A, Lo Cascio, G, Concia, E, Mikulska, M, Viscoli, C, Maximova, N, Candoni, A, Oliveri, S, Lombardi, G, Pitzurra, L, Sanguinetti, Maurizio, Masciari, R, Santantonio, T, Andreoni, S, Barchiesi, F, Pecile, P, Farina, C, Viale, P, Specchia, G, Caggiano, G, Pagano, Livio, Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Pagano, Livio (ORCID:0000-0001-8287-928X), Montagna, Mt, Lovero, G, Coretti, C, Martinelli, D, Delia, M, De Giglio, O, Caira, M, Puntillo, F, D'Antonio, D, Venditti, M, Sambri, V, Di Bernardo, F, Barbui, A, Lo Cascio, G, Concia, E, Mikulska, M, Viscoli, C, Maximova, N, Candoni, A, Oliveri, S, Lombardi, G, Pitzurra, L, Sanguinetti, Maurizio, Masciari, R, Santantonio, T, Andreoni, S, Barchiesi, F, Pecile, P, Farina, C, Viale, P, Specchia, G, Caggiano, G, Pagano, Livio, Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), and Pagano, Livio (ORCID:0000-0001-8287-928X)

Abstract

We compared the risk factors, the diagnostic tools and the outcome of filamentous fungal infections (FFIs) in hematological patients (HAEs) and non-hematological patients (non-HAEs).

Published
2013

32. SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients

Author

Montagna, M. T., primary, Lovero, G., additional, Coretti, C., additional, Martinelli, D., additional, Delia, M., additional, De Giglio, O., additional, Caira, M., additional, Puntillo, F., additional, D’Antonio, D., additional, Venditti, M., additional, Sambri, V., additional, Di Bernardo, F., additional, Barbui, A., additional, Lo Cascio, G., additional, Concia, E., additional, Mikulska, M., additional, Viscoli, C., additional, Maximova, N., additional, Candoni, A., additional, Oliveri, S., additional, Lombardi, G., additional, Pitzurra, L., additional, Sanguinetti, M., additional, Masciari, R., additional, Santantonio, T., additional, Andreoni, S., additional, Barchiesi, F., additional, Pecile, P., additional, Farina, C., additional, Viale, P., additional, Specchia, G., additional, Caggiano, G., additional, and Pagano, L., additional

Published
2013
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36. The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma

Author

Carvalho, A, primary, Cunha, C, additional, Almeida, A J, additional, Osório, N S, additional, Saraiva, M, additional, Teixeira-Coelho, M, additional, Pedreiro, S, additional, Torrado, E, additional, Domingues, N, additional, Gomes-Alves, A G, additional, Marques, A, additional, Lacerda, J F, additional, da Silva, M G, additional, Gomes, M, additional, Pinto, A C, additional, Torres, F, additional, Rendeiro, P, additional, Tavares, P, additional, Di Ianni, M, additional, Medeiros, R, additional, Heutink, P, additional, Bracci, P M, additional, Conde, L, additional, Ludovico, P, additional, Pedrosa, J, additional, Maciel, P, additional, Pitzurra, L, additional, Aversa, F, additional, Marques, H, additional, Paiva, A, additional, Skibola, C F, additional, Romani, L, additional, Castro, A G, additional, and Rodrigues, F, additional

Published
2011
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40. Thymosin 1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo

Author

Bozza, S., primary, Gaziano, R., additional, Bonifazi, P., additional, Zelante, T., additional, Pitzurra, L., additional, Montagnoli, C., additional, Moretti, S., additional, Castronari, R., additional, Sinibaldi, P., additional, Rasi, G., additional, Garaci, E., additional, Bistoni, F., additional, and Romani, L., additional

Published
2007
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44. Multicenter Comparative Evaluation of Six Commercial Systems and the National Committee for Clinical Laboratory Standards M27-A Broth Microdilution Method for Fluconazole Susceptibility Testing of Candida Species

Author

Morace, G., primary, Amato, G., additional, Bistoni, F., additional, Fadda, G., additional, Marone, P., additional, Montagna, M. T., additional, Oliveri, S., additional, Polonelli, L., additional, Rigoli, R., additional, Mancuso, I., additional, La Face, S., additional, Masucci, L., additional, Romano, L., additional, Napoli, C., additional, Tatò, D., additional, Buscema, M. G., additional, Belli, C. M. C., additional, Piccirillo, M. M., additional, Conti, S., additional, Covan, S., additional, Fanti, F., additional, Cavanna, C., additional, D'Alò, F., additional, and Pitzurra, L., additional

Published
2002
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