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In The Pituitary Gland and Adrenal Glands: New Research, the authors first discuss pituicytomas, rare primary glial neoplasms that arise in the neurohypophysis (or posterior portion) of the pituitary gland. They typically present with signs and symptoms of a slow growing, non-hormonally active mass of the sellar and suprasellar region, compressing adjacent structures. Following this, the clinical and pathologic features of spindle cell oncocytomas are discussed. Spindle cell oncocytomas are rare tumors, accounting for less than 0.5% of sellar masses. Tumors typically present in adults and most commonly manifest with visual disturbances and pituitary hypofunction. Additionally, the authors review the clinical and pathological features of gangliocytomas, rare benign tumors of the neuroaxis. They are most commonly seen in children and young adults, and most often arise in the cerebellum as part of Cowden's disease, or in the sellar region. The clinicopathologic features of granular tumors, rare neoplasms that most commonly arise in the neurohypophysis or posterior portion of the pituitary gland, are also discussed. This compilation goes on to examine the adrenal glands, paired structures located superior to the kidneys in the retroperitoneal space. Mineralocorticoids, glucocorticoids and adrenal androgens are synthesized respectively in the zona glomerulosa, zona fasciculatis and zona reticularis that make up the cortex, while the inner adrenal medulla produces the catecholamines and peptides. The risk of developing adrenal insufficiency among glucocorticoid users is assessed, and risk factors are identified. Glucocorticoids are widely used for the treatment of various inflammatory conditions and malignancies, as well as after organ transplantation. The closing study explores hypothalamic-pituitary-adrenal axis activation, a potent and complex response to heat stress in domestic livestock. The hypothalamic-pituitary-adrenal axis is activated during stress, which leads to the secretion of cortisol and aldosterone from the adrenal gland.

The Pituitary, Fourth Edition, continues the tradition of a cogent blend of basic science and clinical medicine which has been the successful hallmark of prior editions. This comprehensive text is devoted to the pathogenesis, diagnosis, and treatment of pituitary disorders. The new edition has been extensively revised to reflect new knowledge derived from advances in molecular and cell biology, biochemistry, diagnostics, and therapeutics as they apply to the pituitary gland. The wide spectrum of clinical disorders emanating from dysfunction of the master gland is described in detail by experts in the field. Fundamental mechanisms underlying disease pathogenesis are presented to provide the reader with an in-depth understanding of mechanisms subserving both normal and disordered pituitary hormone secretion and action. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders. Chapters provide medical students, clinical and basic endocrinology trainees, endocrinologists, internists, pediatricians, gynecologists, and neurosurgeons with a comprehensive, yet integrated, text devoted to the science and art of pituitary medicine. - Brings together pituitary experts from all areas of research and practice who take readers all the way from bench research, to genomic and proteomic analysis, clinical analysis, and new therapeutic approaches to pituitary disorders - Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of issues related to normal and diseased pituitary function - Provides a common language for endocrinologists, neurosurgeons, OB/GYNs, and endocrine researchers to discuss how the pituitary gland and hormones affect each major organ system

Function and disease of the pituitary gland have long been at the center of research interest. Based on a recent meeting held at Iguazu Falls, Argentina, this volume of Frontiers of Hormone Research highlights scientifically exciting and clinically relevant areas in this fast-developing field. Renowned specialists and experts from Latin and North America, Europe and Australia discuss in their contributions various aspects of tumorigenesis, prolactinomas, hormone regulation and action, growth hormone and acromegaly, hypothalamic-pituitary-adrenal axis as well as Cushing disease. A fascinating update on selected issues in basic and clinical research, this book will be of great interest to both neuroendocrinologists and endocrinologists working on pituitary diseases and related issues.

The Pituitary, 2nd Edition is the authoritative resource on the function, dysfunction and treatment of the pituitary. Featuring over 400 illustrations and tables, the healthcare professional will gain a visual understanding of the material in the text. Top endocrinologists and specialists from around the world present only the most accurate and current information by: --Providing twenty-one newly revised in-depth chapters, including a new chapter on Pituitary Surgery --Addressing innovative topics such as new hormone discoveries and new therapeutic advances --Answering the need for a single text devoted to basic physiology and clinical aspects of pituitary function and disease With renowned authorship, The Pituitary, 2nd Edition is a must-have text!