27 results on '"Pittet, Olivier"'
Search Results
2. Does an Antibiotic Stewardship Applied in a Pig Farm Lead to Low ESBL Prevalence?
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Fournier, Claudine, Nordmann, Patrice, Pittet, Olivier, and Poirel, Laurent
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ESBL ,pigs ,mobilized colistin resistance ,Therapeutics. Pharmacology ,RM1-950 ,colistin ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,Article - Abstract
Background. The aim of the present study was to prospectively evaluate the prevalence of intestinal carriage of colistin-resistant and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales among pigs from a Swiss farm attending an animal health and antibiotic stewardship program and to determine the associated mechanisms of resistance. Materials/Methods. Eighty-one fecal samples were recovered and screened for either β-lactam-resistant, colistin-resistant, or aminoglycoside-resistant Enterobacterales, using respective screening media. All recovered isolates were tested for antimicrobial susceptibility and their clonal relationship (PFGE and MLST). Plasmid typing was performed by plasmid-based replicon typing (PBRT). Resistance genes were searched by PCR and sequencing. Results. A total of 38 ESBL-producing Escherichia coli and a single ESBL-producing Enterobacter cloacae were recovered from 81 pigs, corresponding to a prevalence of 50%, no other β-lactamase producer being identified. Among the 38 ESBL-producing E. coli, all belonged to sequence type (ST) ST10, except two ST34 and ST744 isolates. Among the ST10-blaCTX-M-1 isolates, three subclones (n = 22, n = 13, and n = 1, respectively) were identified according to the PFGE analysis. The most commonly identified IncI1 plasmid harboring the blaCTX-M-1 gene was 143 kb in size and coharbored other resistance genes. Only three colistin-resistant Enterobacterales isolates were recovered, namely two Klebsiella pneumoniae isolates and a single E. cloacae isolate. Screening for the plasmid-borne mcr-1 to mcr-9 genes in these three isolates gave negative results. The two K. pneumoniae isolates were clonally related, belonged to ST76, and harbored a truncated mgrB chromosomal gene being the source of colistin resistance. Conclusion. A high prevalence of fecal carriage of ESBL-producing E. coli was found, being mainly caused by the spread of a clonal lineage within the farm. By contrast, a low prevalence of colistin-resistant Enterobacterales was found.
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- 2021
3. Recurrent Left Colonic Diverticulitis Episodes: More Severe Than the Initial Diverticulitis?
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Pittet, Olivier, Kotzampassakis, Nikos, Schmidt, Sabine, Denys, Alban, Demartines, Nicolas, and Calmes, Jean-Marie
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- 2009
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4. Video-assisted Thoracoscopic Resection of a Small Pulmonary Nodule after Computed Tomography–guided Localization with a Hook-wire System: Experience in 45 Consecutive Patients
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Pittet, Olivier, Christodoulou, Michel, Pezzetta, Edgardo, Schmidt, Sabine, Schnyder, Pierre, and Ris, Hans-Beat
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- 2007
- Full Text
- View/download PDF
5. Effect of the TAT-RasGAP 317–326 peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light
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Pittet, Olivier, Petermann, David, Michod, David, Krueger, Thorsten, Cheng, Cai, Ris, Hans-Beat, and Widmann, Christian
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- 2007
- Full Text
- View/download PDF
6. Complicated intra-abdominal infections in Europe: a comprehensive review of the CIAO study
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Sartelli Massimo, Catena Fausto, Ansaloni Luca, Leppaniemi Ari, Taviloglu Korhan, van Goor Harry, Viale Pierluigi, Lazzareschi Daniel, Coccolini Federico, Corbella Davide, de Werra Carlo, Marrelli Daniele, Colizza Sergio, Scibè Rodolfo, Alis Halil, Torer Nurkan, Navarro Salvador, Sakakushev Boris, Massalou Damien, Augustin Goran, Catani Marco, Kauhanen Saila, Pletinckx Pieter, Kenig Jakub, Di Saverio Salomone, Jovine Elio, Guercioni Gianluca, Skrovina Matej, Diaz-Nieto Rafael, Ferrero Alessandro, Rausei Stefano, Laine Samipetteri, Major Piotr, Angst Eliane, Pittet Olivier, Herych Ihor, Agresta Ferdinando, Vettoretto Nereo, Poiasina Elia, Tepp Jaan, Weiss Gunter, Vasquez Giorgio, Vladov Nikola, Tranà Cristian, Delibegovic Samir, Dziki Adam, Giraudo Giorgio, Pereira Jorge, Tzerbinis Helen, van Dellen David, Hutan Martin, Vereczkei Andras, Krasniqi Avdyl, Seretis Charalampos, Mesina Cristian, Rems Miran, Campanile Fabio, Coletta Pietro, Uotila-Nieminen Mirjami, Dente Mario, Bouliaris Konstantinos, Lasithiotakis Konstantinos, Khokha Vladimir, Zivanovic Dragoljub, Smirnov Dmitry, Marinis Athanasios, Negoi Ionut, Ney Ludwig, Bini Roberto, Leon Miguel, Aloia Sergio, Huchon Cyrille, Moldovanu Radu, de Melo Renato, Giakoustidis Dimitrios, Ioannidis Orestis, Cucchi Michele, Pintar Tadeja, Krivokapic Zoran, and Petrovic Jelena
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Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract The CIAO Study (“Complicated Intra-Abdominal infection Observational” Study) is a multicenter investigation performed in 68 medical institutions throughout Europe over the course of a 6-month observational period (January-June 2012). Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study. 2,152 patients with a mean age of 53.8 years (range: 4–98 years) were enrolled in the study. 46.3% of the patients were women and 53.7% were men. Intraperitoneal specimens were collected from 62.2% of the enrolled patients, and from these samples, a variety of microorganisms were collectively identified. The overall mortality rate was 7.5% (163/2.152). According to multivariate analysis of the compiled data, several criteria were found to be independent variables predictive of patient mortality, including patient age, the presence of an intestinal non-appendicular source of infection (colonic non-diverticular perforation, complicated diverticulitis, small bowel perforation), a delayed initial intervention (a delay exceeding 24 hours), sepsis and septic shock in the immediate post-operative period, and ICU admission. Given the sweeping geographical distribution of the participating medical centers, the CIAO Study gives an accurate description of the epidemiological, clinical, microbiological, and treatment profiles of complicated intra-abdominal infections (IAIs) throughout Europe.
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- 2012
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7. Complicated intra-abdominal infections in Europe: preliminary data from the first three months of the CIAO Study
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Sartelli Massimo, Catena Fausto, Ansaloni Luca, Leppaniemi Ari, Taviloglu Korhan, van Goor Harry, Viale Pierluigi, Lazzareschi Daniel, de Werra Carlo, Marrelli Daniele, Colizza Sergio, Scibé Rodolfo, Alis Halil, Torer Nurkan, Navarro Salvador, Catani Marco, Kauhanen Saila, Augustin Goran, Sakakushev Boris, Massalou Damien, Pletinckx Pieter, Kenig Jakub, Di Saverio Salomone, Guercioni Gianluca, Rausei Stefano, Laine Samipetteri, Major Piotr, Skrovina Matej, Angst Eliane, Pittet Olivier, Gerych Ihor, Tepp Jaan, Weiss Guenter, Vasquez Giorgio, Vladov Nikola, Tranà Cristian, Vettoretto Nereo, Delibegovic Samir, Dziki Adam, Giraudo Giorgio, Pereira Jorge, Poiasina Elia, Tzerbinis Helen, Hutan Martin, Vereczkei Andras, Krasniqi Avdyl, Seretis Charalampos, Diaz-Nieto Rafael, Mesina Cristian, Rems Miran, Campanile Fabio, Agresta Ferdinando, Coletta Pietro, Uotila-Nieminen Mirjami, Dente Mario, Bouliaris Konstantinos, Lasithiotakis Konstantinos, Khokha Vladimir, Zivanović Dragoljub, Smirnov Dmitry, Marinis Athanasios, Negoi Ionut, Ney Ludwig, Bini Roberto, Leon Miguel, Aloia Sergio, Huchon Cyrille, Moldovanu Radu, de Melo Renato, Giakoustidis Dimitrios, Ioannidis Orestis, Cucchi Michele, Pintar Tadeja, and Jovine Elio
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Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract The CIAO Study is a multicenter observational study currently underway in 66 European medical institutions over the course of a six-month study period (January-June 2012). This preliminary report overviews the findings of the first half of the study, which includes all data from the first three months of the six-month study period. Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study. 912 patients with a mean age of 54.4 years (range 4–98) were enrolled in the study during the first three-month period. 47.7% of the patients were women and 52.3% were men. Among these patients, 83.3% were affected by community-acquired IAIs while the remaining 16.7% presented with healthcare-associated infections. Intraperitoneal specimens were collected from 64.2% of the enrolled patients, and from these samples, 825 microorganisms were collectively identified. The overall mortality rate was 6.4% (58/912). According to univariate statistical analysis of the data, critical clinical condition of the patient upon hospital admission (defined by severe sepsis and septic shock) as well as healthcare-associated infections, non-appendicular origin, generalized peritonitis, and serious comorbidities such as malignancy and severe cardiovascular disease were all significant risk factors for patient mortality. White Blood Cell counts (WBCs) greater than 12,000 or less than 4,000 and core body temperatures exceeding 38°C or less than 36°C by the third post-operative day were statistically significant indicators of patient mortality.
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- 2012
- Full Text
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8. Recurrent Left Colonic Diverticulitis Episodes: More Severe Than the Initial Diverticulitis?
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Pittet, Olivier, Kotzampassakis, Nikos, Schmidt, Sabine, Denys, Alban, Demartines, Nicolas, Calmes, Jean-Marie, Pittet, Olivier, Kotzampassakis, Nikos, Schmidt, Sabine, Denys, Alban, Demartines, Nicolas, and Calmes, Jean-Marie
- Abstract
Background: Until recently, it was accepted that the rate of complications and failure of medical therapy were higher during recurrent episodes of diverticulitis. New data and new interpretation of older studies have challenged this opinion. The aim of the present study was to determine whether recurrent diverticulitis in comparison with the initial episode has a different short-term outcome after medical or surgical treatment. Methods: This was a retrospective cohort study of 271 consecutive patients admitted for diverticulitis confirmed by computed tomography (CT) between 2001 and 2004. Altogether 202 patients had an initial episode (group I), and 69 had recurrent diverticulitis (group R). A total of 20 clinical and 15 radiologic parameters were analyzed and compared between the two groups, including need for surgery, clinical presentation at admission, response to treatment, complications, laboratory parameters, and pathologic CT features (colonic wall thickening, abscess, pneumoperitoneum, free intraperitoneal fluid). An unpaired Student's t-test and Fisher's and Wilcoxon's tests were applied for statistical analysis. Results: None of the clinical or radiologic parameters was statistically different between the two groups. Regarding surgery, 15.8% of the group I patients needed surgery at admission compared to 5.8% in group R (p=0.04). Conservative treatment failure was similar in the two groups (10.7% vs. 10.0%; p=0.84). There was 3% mortality at 30days in group I compared to 0% in group R. Conclusions: Recurrent episodes of diverticulitis do not lead to more complications and more conservative treatment failure. Moreover, surgery at admission was less frequent among patients who presented with a recurrence
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- 2018
9. Video-assisted Thoracoscopic Resection of a Small Pulmonary Nodule after Computed Tomography-guided Localization with a Hook-wire System: Experience in 45 Consecutive Patients
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Pittet, Olivier, Christodoulou, Michel, Pezzetta, Edgardo, Schmidt, Sabine, Schnyder, Pierre, Ris, Hans-Beat, Pittet, Olivier, Christodoulou, Michel, Pezzetta, Edgardo, Schmidt, Sabine, Schnyder, Pierre, and Ris, Hans-Beat
- Abstract
Background: This study is a single-institution validation of video-assisted thoracoscopic (VATS) resection of a small solitary pulmonary nodule (SPN) previously localized by a CT-guided hook-wire system in a consecutive series of 45 patients. Methods: The records of all patients undergoing VATS resection for SPN preoperatively localized by CT-guided a hook-wire system from January 2002 to December 2004 were assessed with respect to failure to localize the lesion by the hook-wire system, conversion thoracotomy rate, duration of operation, postoperative complications, and histology of SPN. Results: Forty-five patients underwent 49 VATS resections, with simultaneous bilateral SPN resection performed in 4. Preoperative CT-guided hook-wire localization failed in two patients (4%). Conversion thoracotomy was necessary in two patients (4%) because it was not possible to resect the lesion by a VATS approach. The average operative time was 50 min. Postoperative complications occurred in 3 patients (6%), one hemothorax and two pneumonia. The mean hospital stay was 5 days (range: 2-18 days). Histological assessment revealed inflammatory disease in 17 patients (38%), metastasis in 17 (38%), non-small-cell lung cancer (NSCLC) in 4 (9%), lymphoma in 3 (6%), interstitial fibrosis in 2 (4%), histiocytoma in one (2%), and hamartoma in one (2%). Conclusions: Histological analysis of resected SPN revealed unexpected malignant disease in more than 50% of the patients indicating that histological clarification of SPN seems warranted. Video-assisted thoracoscopic resection of SPN previously localized by a CT-guided hook-wire system is related to a low conversion thoracotomy rate, a short operation time, and few postoperative complications, and it is well suited for the clarification of SPN
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- 2018
10. Video: Balkenmäher im Vergleich: Rapid, Aebi, Enorossi, Gaspardo, Brielmaier und Wepfer
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Alföldi, Thomas, Pittet, Olivier, Alföldi, Thomas, and Pittet, Olivier
- Abstract
Das Video zeigt verschiedene insektenschonende Balkennmähwerke. Die modernen Mäher mit Mähbreiten von 2 bis 11 Metern gibt es als frontal oder seitlich angebaute Versionen. Ein Vorteil dieser Mähwerke ist ihr geringer Leistungsbedarf: einige brauchen weniger als 2,5 kW pro Meter Schnittbreite. Eine weitere Stärke der Balkenmäher ist, dass sie die Insekten schonen, die man zum Beispiel auf den extensiven Wiesen findet.
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- 2015
11. Vidéo: Démo Faucheuses: Rapid, Aebi, Enorossi, Gaspardo, Brielmaier, Wepfer
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Alföldi, Thomas, Pittet, Olivier, Alföldi, Thomas, and Pittet, Olivier
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Le film montre les faucheuses modernes et innovantes de 2 à près de 11 mètres de large, en version portées ou même télécommandées. Un avantage de ces faucheuses est certainement leur faible exigence de puissance : certaines d’entre elles ont besoin de moins de 2,5 kW par mètre de largeur. Un autre atout est leur faible impact sur les populations d’insectes que l’on trouve dans les prairies extensives par exemple.
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- 2015
12. [b]Diverticulites[/b] sigmoïdiennes aiguës : vers un traitement de plus en plus conservateur
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Joliat, Gaëtan-Romain, primary, Pittet, Olivier, additional, Demartines, Nicolas, additional, and Hahnloser, Dieter, additional
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- 2015
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13. [b]Diverticulite :[/b] opérer ou pas ?
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Abetel, Gilbert, primary, Lavrek, M. Dejan, additional, Pittet, Olivier, additional, Hahnloser, Dieter, additional, and Plan, Pierre-Alain, additional
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- 2015
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14. Douleur anale aiguë
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Pittet, Olivier, primary, Demartines, Nicolas, additional, and Hahnloser, Dieter, additional
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- 2014
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15. À propos de l'Armée XXI
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Pittet, Olivier
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- 2003
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16. Adieu aux régiments d'infanterie
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Pittet, Olivier
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- 2003
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17. Complicated intra-abdominal infections in Europe: a comprehensive review of the CIAO study
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University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Leppäniemi, Ari, Taviloglu, Korhan, van Goor, Harry, Viale, Pierluigi, Lazzareschi, Daniel Vasco, Coccolini, Federico, Corbella, Davide, de Werra, Carlo, Marrelli, Daniele, Colizza, Sergio, Scibe, Rodolfo, Alis, Halil, Torer, Nurkan, Navarro, Salvador, Sakakushev, Boris, Massalou, Damien, Augustin, Goran, Catani, Marco, Kauhanen, Saila, Pletinckx, Pieter, Kenig, Jakub, Di Saverio, Salomone, Jovine, Elio, Guercioni, Gianluca, Skrovina, Matej, Diaz-Nieto, Rafael, Ferrero, Alessandro, Rausei, Stefano, Laine, Samipetteri, Major, Piotr, Angst, Eliane, Pittet, Olivier, Herych, Ihor, Agresta, Ferdinando, Vettoretto, Nereo, Poiasina, Elia, Tepp, Jaan, Weiss, Gunter, Vasquez, Giorgio, Vladov, Nikola, Trana, Cristian, Delibegovic, Samir, Dziki, Adam, Giraudo, Giorgio, Pereira, Jorge, Tzerbinis, Helen, van Dellen, David, Hutan, Martin, Vereczkei, Andras, Krasniqi, Avdyl, Seretis, Charalampos, Mesina, Cristian, Rems, Miran, Campanile, Fabio Cesare, Coletta, Pietro, Uotila-Nieminen, Mirjami, Dente, Mario, Bouliaris, Konstantinos, Lasithiotakis, Konstantinos, Khokha, Vladimir, Zivanovic, Dragoljub, Smirnov, Dmitry, Marinis, Athanasios, Negoi, Ionut, Ney, Ludwig, Bini, Roberto, Leon, Miguel, Aloia, Sergio, Huchon, Cyrille, Moldovanu, Radu, de Melo, Renato Bessa, Giakoustidis, Dimitrios, Ioannidis, Orestis, Cucchi, Michele, Pintar, Tadeja, Krivokapic, Zoran, Petrovic, Jelena, University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Leppäniemi, Ari, Taviloglu, Korhan, van Goor, Harry, Viale, Pierluigi, Lazzareschi, Daniel Vasco, Coccolini, Federico, Corbella, Davide, de Werra, Carlo, Marrelli, Daniele, Colizza, Sergio, Scibe, Rodolfo, Alis, Halil, Torer, Nurkan, Navarro, Salvador, Sakakushev, Boris, Massalou, Damien, Augustin, Goran, Catani, Marco, Kauhanen, Saila, Pletinckx, Pieter, Kenig, Jakub, Di Saverio, Salomone, Jovine, Elio, Guercioni, Gianluca, Skrovina, Matej, Diaz-Nieto, Rafael, Ferrero, Alessandro, Rausei, Stefano, Laine, Samipetteri, Major, Piotr, Angst, Eliane, Pittet, Olivier, Herych, Ihor, Agresta, Ferdinando, Vettoretto, Nereo, Poiasina, Elia, Tepp, Jaan, Weiss, Gunter, Vasquez, Giorgio, Vladov, Nikola, Trana, Cristian, Delibegovic, Samir, Dziki, Adam, Giraudo, Giorgio, Pereira, Jorge, Tzerbinis, Helen, van Dellen, David, Hutan, Martin, Vereczkei, Andras, Krasniqi, Avdyl, Seretis, Charalampos, Mesina, Cristian, Rems, Miran, Campanile, Fabio Cesare, Coletta, Pietro, Uotila-Nieminen, Mirjami, Dente, Mario, Bouliaris, Konstantinos, Lasithiotakis, Konstantinos, Khokha, Vladimir, Zivanovic, Dragoljub, Smirnov, Dmitry, Marinis, Athanasios, Negoi, Ionut, Ney, Ludwig, Bini, Roberto, Leon, Miguel, Aloia, Sergio, Huchon, Cyrille, Moldovanu, Radu, de Melo, Renato Bessa, Giakoustidis, Dimitrios, Ioannidis, Orestis, Cucchi, Michele, Pintar, Tadeja, Krivokapic, Zoran, and Petrovic, Jelena
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- 2012
18. De l'armée de métier
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Pittet, Olivier
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- 1998
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19. Der akute anale Schmerz
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Pittet, Olivier, primary, Demartines, Nicolas, additional, and Hahnloser, Dieter, additional
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- 2013
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20. Effect of the TAT-RasGAP317–326 peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light
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Pittet, Olivier, primary, Petermann, David, additional, Michod, David, additional, Krueger, Thorsten, additional, Cheng, Cai, additional, Ris, Hans-Beat, additional, and Widmann, Christian, additional
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- 2007
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21. Diagnosis of Birt-Hogg-Dube Syndrome in a Patient With Spontaneous Pneumothorax
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Pittet, Olivier, primary, Christodoulou, Michel, additional, Staneczek, Olivier, additional, and Ris, Hans-Beat, additional
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- 2006
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22. Effect of the TAT-RasGAP317–326 peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light
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Pittet, Olivier, Petermann, David, Michod, David, Krueger, Thorsten, Cheng, Cai, Ris, Hans-Beat, and Widmann, Christian
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PEPTIDES , *APOPTOSIS , *CANCER cells , *FIBROBLASTS - Abstract
Abstract: Background: 5,10,15,20-Tetrakis(m-hydroxyphenyl)chlorin (mTHPC)-mediated photodynamic therapy (PDT) has shown insufficient tumor selectivity for the treatment of pleural mesothelioma. Tumor selectivity of mTHPC-PDT may be enhanced in the presence of the TAT-RasGAP317–326 peptide which has the potential to specifically sensitize tumor cells to cytostatic agents. Materials and methods: H-meso-1 and human fibroblast cell cultures, respectively, were exposed to two different mTHPC doses followed by light delivery with and without TAT-RasGAP317–326 administration. mTHPC was added to the cultures at a concentration of 0.04μg/ml and 0.10μg/ml, respectively, 24h before laser light illumination at 652nm (3J/cm2, 40mW/cm2). TAT-RasGAP317–326 was added to the cultures immediately after light delivery at a concentration of 20μM. The apoptosis rate was determined by scoring the cells displaying pycnotic nuclei. Cell viability was measured by using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Results: Light delivery associated with 0.04μg/ml mTHPC resulted in a significantly higher apoptosis rate in the presence of TAT-RasGAP317–326 than without in H-meso-1 cells (p <0.05) but not in fibroblasts. In contrast, 1.0μg/ml mTHPC and light resulted in a significantly higher apoptosis rate in both H-meso-1 cells and fibroblasts as compared to controls (p <0.05) but the addition of TAT-RasGAP317–326 did not lead to a further significant increase of the apoptosis rate of both H-meso-1 cells and fibroblasts as compared to mTHPC and light delivery alone. Conclusion: TAT-RasGAP317–326 selectively enhanced the effect of mTHPC and light delivery on H-meso-1 cells but not on fibroblasts. However, this effect was mTHPC dose-dependent and occurred only at a low sensitizer dose. [Copyright &y& Elsevier]
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- 2007
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23. Du pousse-cailloux au commandant de corps : souvenirs et réflexions
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Pittet, Olivier and Buman, Dominique de
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- 1982
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24. Complicated intra-abdominal infections in Europe: preliminary data from the first three months of the CIAO Study
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Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Leppaniemi, Ari, Taviloglu, Korhan, Van Goor, Harry, Viale, Pierluigi, Lazzareschi, Daniel Vasco, De Werra, Carlo, Marrelli, Daniele, Colizza, Sergio, Scibé, Rodolfo, Alis, Halil, Torer, Nurkan, Navarro, Salvador, Catani, Marco, Kauhanen, Saila, Augustin, Goran, Sakakushev, Boris, Massalou, Damien, Pletinckx, Pieter, Kenig, Jakub, Di Saverio, Salomone, Guercioni, Gianluca, Rausei, Stefano, Laine, Samipetteri, Major, Piotr, Skrovina, Matej, Angst, Eliane, Pittet, Olivier, Gerych, Ihor, Tepp, Jaan, Weiss, Guenter, Vasquez, Giorgio, Vladov, Nikola, Tranà, Cristian, Vettoretto, Nereo, Delibegovic, Samir, Dziki, Adam, Giraudo, Giorgio, Pereira, Jorge, Poiasina, Elia, Tzerbinis, Helen, Hutan, Martin, Vereczkei, Andras, Krasniqi, Avdyl, Seretis, Charalampos, Diaz-Nieto, Rafael, Mesina, Cristian, Rems, Miran, Campanile, Fabio Cesare, Agresta, Ferdinando, Coletta, Pietro, Uotila-Nieminen, Mirjami, Dente, Mario, Bouliaris, Konstantinos, Lasithiotakis, Konstantinos, Khokha, Vladimir, Zivanović, Dragoljub, Smirnov, Dmitry, Marinis, Athanasios, Negoi, Ionut, Ney, Ludwig, Bini, Roberto, Leon, Miguel, Aloia, Sergio, Huchon, Cyrille, Moldovanu, Radu, De Melo, Renato Bessa, Giakoustidis, Dimitrios, Ioannidis, Orestis, Cucchi, Michele, Pintar, Tadeja, and Jovine, Elio
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3. Good health - Abstract
The CIAO Study is a multicenter observational study currently underway in 66 European medical institutions over the course of a six-month study period (January-June 2012).This preliminary report overviews the findings of the first half of the study, which includes all data from the first three months of the six-month study period.Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study.912 patients with a mean age of 54.4 years (range 4-98) were enrolled in the study during the first three-month period. 47.7% of the patients were women and 52.3% were men. Among these patients, 83.3% were affected by community-acquired IAIs while the remaining 16.7% presented with healthcare-associated infections. Intraperitoneal specimens were collected from 64.2% of the enrolled patients, and from these samples, 825 microorganisms were collectively identified.The overall mortality rate was 6.4% (58/912). According to univariate statistical analysis of the data, critical clinical condition of the patient upon hospital admission (defined by severe sepsis and septic shock) as well as healthcare-associated infections, non-appendicular origin, generalized peritonitis, and serious comorbidities such as malignancy and severe cardiovascular disease were all significant risk factors for patient mortality.White Blood Cell counts (WBCs) greater than 12,000 or less than 4,000 and core body temperatures exceeding 38°C or less than 36°C by the third post-operative day were statistically significant indicators of patient mortality.
25. Recurrent Left Colonic Diverticulitis Episodes: More Severe Than the Initial Diverticulitis?
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Pittet, Olivier, Kotzampassakis, Nikos, Schmidt, Sabine, Denys, Alban, Demartines, Nicolas, Calmes, Jean-Marie, Pittet, Olivier, Kotzampassakis, Nikos, Schmidt, Sabine, Denys, Alban, Demartines, Nicolas, and Calmes, Jean-Marie
- Abstract
Background: Until recently, it was accepted that the rate of complications and failure of medical therapy were higher during recurrent episodes of diverticulitis. New data and new interpretation of older studies have challenged this opinion. The aim of the present study was to determine whether recurrent diverticulitis in comparison with the initial episode has a different short-term outcome after medical or surgical treatment. Methods: This was a retrospective cohort study of 271 consecutive patients admitted for diverticulitis confirmed by computed tomography (CT) between 2001 and 2004. Altogether 202 patients had an initial episode (group I), and 69 had recurrent diverticulitis (group R). A total of 20 clinical and 15 radiologic parameters were analyzed and compared between the two groups, including need for surgery, clinical presentation at admission, response to treatment, complications, laboratory parameters, and pathologic CT features (colonic wall thickening, abscess, pneumoperitoneum, free intraperitoneal fluid). An unpaired Student's t-test and Fisher's and Wilcoxon's tests were applied for statistical analysis. Results: None of the clinical or radiologic parameters was statistically different between the two groups. Regarding surgery, 15.8% of the group I patients needed surgery at admission compared to 5.8% in group R (p=0.04). Conservative treatment failure was similar in the two groups (10.7% vs. 10.0%; p=0.84). There was 3% mortality at 30days in group I compared to 0% in group R. Conclusions: Recurrent episodes of diverticulitis do not lead to more complications and more conservative treatment failure. Moreover, surgery at admission was less frequent among patients who presented with a recurrence
26. Video-assisted Thoracoscopic Resection of a Small Pulmonary Nodule after Computed Tomography-guided Localization with a Hook-wire System: Experience in 45 Consecutive Patients
- Author
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Pittet, Olivier, Christodoulou, Michel, Pezzetta, Edgardo, Schmidt, Sabine, Schnyder, Pierre, Ris, Hans-Beat, Pittet, Olivier, Christodoulou, Michel, Pezzetta, Edgardo, Schmidt, Sabine, Schnyder, Pierre, and Ris, Hans-Beat
- Abstract
Background: This study is a single-institution validation of video-assisted thoracoscopic (VATS) resection of a small solitary pulmonary nodule (SPN) previously localized by a CT-guided hook-wire system in a consecutive series of 45 patients. Methods: The records of all patients undergoing VATS resection for SPN preoperatively localized by CT-guided a hook-wire system from January 2002 to December 2004 were assessed with respect to failure to localize the lesion by the hook-wire system, conversion thoracotomy rate, duration of operation, postoperative complications, and histology of SPN. Results: Forty-five patients underwent 49 VATS resections, with simultaneous bilateral SPN resection performed in 4. Preoperative CT-guided hook-wire localization failed in two patients (4%). Conversion thoracotomy was necessary in two patients (4%) because it was not possible to resect the lesion by a VATS approach. The average operative time was 50 min. Postoperative complications occurred in 3 patients (6%), one hemothorax and two pneumonia. The mean hospital stay was 5 days (range: 2-18 days). Histological assessment revealed inflammatory disease in 17 patients (38%), metastasis in 17 (38%), non-small-cell lung cancer (NSCLC) in 4 (9%), lymphoma in 3 (6%), interstitial fibrosis in 2 (4%), histiocytoma in one (2%), and hamartoma in one (2%). Conclusions: Histological analysis of resected SPN revealed unexpected malignant disease in more than 50% of the patients indicating that histological clarification of SPN seems warranted. Video-assisted thoracoscopic resection of SPN previously localized by a CT-guided hook-wire system is related to a low conversion thoracotomy rate, a short operation time, and few postoperative complications, and it is well suited for the clarification of SPN
27. [Acute anal pain].
- Author
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Pittet O, Demartines N, and Hahnloser D
- Subjects
- Acute Pain diagnosis, Acute Pain etiology, Anus Diseases complications, Fissure in Ano complications, Humans, Pelvic Pain diagnosis, Pelvic Pain etiology, Acute Pain prevention & control, Anus Diseases therapy, Fissure in Ano therapy, Pelvic Pain prevention & control
- Abstract
Acute anal pain is a common proctological problem. A detailed history together with the clinical examination are crucial for the diagnosis. An acute perianal vein thrombosis can be successfully excised within the first 72 hours. Acute anal fissures are best treated conservatively using stool regulation and topical medications reducing the sphincter spasm. A chronic anal fissure needs surgery. Perianal abscesses can very often be incised and drained in local anesthesia. Proctalgia fugax and the levator ani syndrome are exclusion diagnoses and are treated symptomatically.
- Published
- 2013
- Full Text
- View/download PDF
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