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645 results on '"Pittaluga, S."'

4. PEDIATRIC NODAL MARGINAL ZONE LYMPHOMA AND PEDIATRIC-TYPE FOLLICULAR LYMPHOMA SHARE A COMMON MOLECULAR PROFILE

Author

Salmeron-Villalobos, J., primary, Egan, C., additional, Borgmann, V., additional, Müller, I., additional, Gonzalez-Farre, B., additional, Ramis-Zaldivar, J., additional, Nann, D., additional, Balagué, O., additional, Lopez-Guerra, M., additional, Colomer, D., additional, Oschlies, I., additional, Klapper, W., additional, Glaser, S., additional, Ko, Y., additional, Bonzheim, I., additional, Siebert, R., additional, Fend, F., additional, Pittaluga, S., additional, Campo, E., additional, Salaverria, I., additional, Jaffe, E., additional, and Quintanilla-Martinez, L., additional

Published
2022
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5. Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome

Author

Rigoni, R, Fontana, E, Dobbs, K, Marrella, V, Taverniti, V, Maina, V, Facoetti, A, D'Amico, G, Al-Herz, W, Cruz-Munoz, M, Schuetz, C, Gennery, A, Garabedian, E, Giliani, S, Draper, D, Dbaibo, G, Geha, R, Meyts, I, Tousseyn, T, Neven, B, Moshous, D, Fischer, A, Schulz, A, Finocchi, A, Kuhns, D, Fink, D, Lionakis, M, Swamydas, M, Guglielmetti, S, Alejo, J, Myles, I, Pittaluga, S, Notarangelo, L, Villa, A, Cassani, B, Rigoni R., Fontana E., Dobbs K., Marrella V., Taverniti V., Maina V., Facoetti A., D'Amico G., Al-Herz W., Cruz-Munoz M. E., Schuetz C., Gennery A. R., Garabedian E. K., Giliani S., Draper D., Dbaibo G., Geha R. S., Meyts I., Tousseyn T., Neven B., Moshous D., Fischer A., Schulz A., Finocchi A., Kuhns D. B., Fink D. L., Lionakis M. S., Swamydas M., Guglielmetti S., Alejo J., Myles I. A., Pittaluga S., Notarangelo L. D., Villa A., Cassani B., Rigoni, R, Fontana, E, Dobbs, K, Marrella, V, Taverniti, V, Maina, V, Facoetti, A, D'Amico, G, Al-Herz, W, Cruz-Munoz, M, Schuetz, C, Gennery, A, Garabedian, E, Giliani, S, Draper, D, Dbaibo, G, Geha, R, Meyts, I, Tousseyn, T, Neven, B, Moshous, D, Fischer, A, Schulz, A, Finocchi, A, Kuhns, D, Fink, D, Lionakis, M, Swamydas, M, Guglielmetti, S, Alejo, J, Myles, I, Pittaluga, S, Notarangelo, L, Villa, A, Cassani, B, Rigoni R., Fontana E., Dobbs K., Marrella V., Taverniti V., Maina V., Facoetti A., D'Amico G., Al-Herz W., Cruz-Munoz M. E., Schuetz C., Gennery A. R., Garabedian E. K., Giliani S., Draper D., Dbaibo G., Geha R. S., Meyts I., Tousseyn T., Neven B., Moshous D., Fischer A., Schulz A., Finocchi A., Kuhns D. B., Fink D. L., Lionakis M. S., Swamydas M., Guglielmetti S., Alejo J., Myles I. A., Pittaluga S., Notarangelo L. D., Villa A., and Cassani B.

Abstract

Background: Severe early-onset erythroderma and gut inflammation, with massive tissue infiltration of oligoclonal activated T cells are the hallmark of Omenn syndrome (OS). Objective: The impact of altered gut homeostasis in the cutaneous manifestations of OS remains to be clarified. Methods: We analyzed a cohort of 15 patients with OS and the 129Sv/C57BL/6 knock-in Rag2R229Q/R229Q (Rag2R229Q) mouse model. Homing phenotypes of circulating lymphocytes were analyzed by flow cytometry. Inflammatory cytokines and chemokines were examined in the sera by ELISA and in skin biopsies by immunohistochemistry and in situ RNA hybridization. Experimental colitis was induced in mice by dextran sulfate sodium salt. Results: We show that memory/activated T cells from patients with OS and from the Rag2R229Q mouse model of OS abundantly express the skin homing receptors cutaneous lymphocyte associated antigen and CCR4 (Ccr4), associated with high levels of chemokine C-C motif ligands 17 and 22. Serum levels of LPS are also elevated. A broad TH1/TH2/TH17 inflammatory signature is detected in the periphery and in the skin. Increased Tlr4 expression in the skin of Rag2R229Q mice is associated with enhanced cutaneous inflammation on local and systemic administration of LPS. Likewise, boosting colitis in Rag2R229Q mice results in increased frequency of Ccr4+ splenic T cells and worsening of skin inflammation, as indicated by epidermal thickening, enhanced epithelial cell activation, and dermal infiltration by TH1 effector T cells. Conclusions: These results support the existence of an interplay between gut and skin that can sustain skin inflammation in OS.

Published
2020

13. 3D modeling and integration of heterogeneous geo-data

Author

Miola, M., Cabiddu, D., Pittaluga, S., Mortara, M., Vetuschi, Zuccolini, and Imitazione, G.

Subjects
Geostatistical analysis, Representation of subsoil, Representation of subsoil, 3D modeling, Geostatistical analysis, 3D modeling
Abstract

This paper tackles the volumetric representation of geophysical and geotechnical data, gathered during exploration surveys of the subsoil. The creation of a 3D model as support to geological interpretation has to take into account the specificity of the diverse input data, that are heterogeneous. Some data are massive, but cover the domain unevenly, e.g., structured along dense differently spaced lines, while others are very sparse, e.g., borehole locations with soil sampling and CPTU (Piezocone Penetration Test) locations. In this work, we focus on the exploration and analysis of underwater deposits. After a discussion about the data typically acquired in an offshore campaign, we present an automatic process to generate the subsurfaces and volume defining an underground deposit, starting from the identification of relevant morphological features in seismic data. In particular, data simplification and refinement based on geostatistics have been applied to generate regular 2D meshes from strongly anisotropic data, in order to improve the quality of the final 3D tetrahedral mesh. Furthermore, we also use geostatistics to predict geotechnical parameters from local surveys and estimate their distribution on the whole domain: in this way the 3D model will include relevant geological features of the deposit and allow extrapolating different geotechnical information with associated uncertainty. The volume characterization and its 3D inspection will improve the structural and stratigraphic interpretation of deposits, to support geological analysis and planning of future engineering activities., Smart Tools and Apps for Graphics - Eurographics Italian Chapter Conference, Modeling, Reconstruction, and Applications, 39, 49, Marianna Miola, Daniela Cabiddu, Simone Pittaluga, Michela Mortara, Marino Vetuschi Zuccolini, and Gianmario Imitazione, Keywords: Representation of subsoil, 3D modeling, Geostatistical analysis

Published
2021

15. Racetrack coils for dedicated MRI magnets

Author

Pittaluga, S., Besio, S., Punzo, V., and Trequattrini, A.

Subjects
Electric coils -- Analysis, Linear programming -- Usage, Magnetic fields -- Analysis, Superconducting magnets -- Design and construction, Business, Electronics, Electronics and electrical industries
Published
2010

16. CHARACTERIZATION OF THE GENETIC LANDSCAPE OF HIGH‐GRADE B‐CELL LYMPHOMA, NOS – AN LLMPP PROJECT

Author

Collinge, B. J., primary, Hilton, L. K, additional, Wong, J., additional, Ben‐Neriah, S., additional, Rushton, C. K., additional, Slack, G. W., additional, Farinha, P., additional, Cook, J. R., additional, Ott, G., additional, Rosenwald, A., additional, Campo, E., additional, Amador, C., additional, Greiner, T. C., additional, Raess, P. W., additional, Song, J. Y., additional, Inghirami, G., additional, Jaffe, E. S., additional, Weisenburger, D. D., additional, Chan, W. C., additional, Holte, H., additional, Beiske, K., additional, Fu, K., additional, Delabie, J., additional, Pittaluga, S., additional, Feldman, A. L., additional, Savage, K. J., additional, Mungall, A. J., additional, Staudt, L. M., additional, Steidl, C., additional, Rimsza, L. M., additional, Morin, R. D., additional, and Scott, D. W., additional

Published
2021
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17. THE MUTATIONAL LANDSCAPE OF DOUBLE/TRIPLE‐HIT HIGH‐GRADE B‐CELL LYMPHOMA WITH BCL2 REARRANGEMENT (DH/TH‐ BCL2 ) – AN LLMPP PROJECT

Author

Collinge, B. J., primary, Hilton, L. K., additional, Wong, J., additional, Ben‐Neriah, S., additional, Alduaij, W., additional, Rushton, C. K., additional, Slack, G. W., additional, Farinha, P., additional, Miyata‐Takata, T., additional, Cook, J. R., additional, Ott, G., additional, Rosenwald, A., additional, Campo, E., additional, Amador, C., additional, Greiner, T. C., additional, Raess, P. W., additional, Song, J. Y., additional, Inghirami, G., additional, Jaffe, E. S., additional, Weisenburger, D. D., additional, Chan, W. C., additional, Holte, H., additional, Beiske, K., additional, Fu, K., additional, Delabie, J., additional, Pittaluga, S., additional, Feldman, A. L., additional, Sehn, L. H., additional, Savage, K. J., additional, Mungall, A. J., additional, Staudt, L. M., additional, Steidl, C., additional, Rimsza, L. M., additional, Morin, R. D., additional, and Scott, D. W., additional

Published
2021
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18. THE TOPOLOGY OF MYC REARRANGEMENTS IN DOUBLE‐HIT LYMPHOMA IS CONSTRAINED BY THE PRECEDING IGH‐BCL2 REARRANGEMENT – AN LLMPP PROJECT

Author

Hilton, L. K., primary, Collinge, B., additional, Ben‐Neriah, S., additional, Grande, B. M., additional, Slack, G. W., additional, Farinha, P., additional, Miyata‐Takata, T., additional, Cook, J. R., additional, Ott, G., additional, Rosenwald, A., additional, Campo, E., additional, Amador, C., additional, Greiner, T. C., additional, Raess, P. W., additional, Song, J. Y., additional, Inghirami, G., additional, Jaffe, E. S., additional, Weisenburger, D. D., additional, Chan, W. C., additional, Holte, H., additional, Beiske, K., additional, Fu, K., additional, Delabie, J., additional, Pittaluga, S., additional, Feldman, A. L., additional, Sehn, L. H., additional, Savage, K. J., additional, Mungall, A. J., additional, Staudt, L. M., additional, Steidl, C., additional, Rimsza, L. M., additional, Morin, R. D., additional, and Scott, D. W., additional

Published
2021
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19. Elliptical coils for dedicated MRI magnets

Author

Besio, S., Pittaluga, S., Punzo, V., and Trequattrini, A.

Subjects
Electric coils -- Design and construction, Magnetic resonance imaging -- Analysis, Superconducting magnets -- Design and construction, Business, Electronics, Electronics and electrical industries
Abstract

An optimization method is described for a 1 T dedicated MRI magnet, which is based on the formalism of elliptical harmonics. The greater complexity of the approach with respect to traditional spherical harmonics can be reduced once the geometric shape of the harmonics is accounted for in the choice of the coefficients to be controlled.

Published
2008

20. Venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR) in relapsed/refractory (R/R) and treatment‐naïve (TN) mantle cell lymphoma (MCL).

Author

Melani, C. J., Lakhotia, R., Pittaluga, S., Phelan, J. D., Yang, Y., Davies‐Hill, T., Simard, J., Muppidi, J., Huang, D. W., Thomas, C. J., Ceribelli, M., Tosto, F. A., Pradhan, A., Juanitez, A. M., Rimsza, L. M., Jacob, A., Simmons, H., Steinberg, S. M., Jaffe, E. S., and Staudt, L. M.

Subjects
MANTLE cell lymphoma, LENALIDOMIDE, VENETOCLAX, REFRACTORY materials, PREDNISONE
Abstract

B Methods: b R/R and TN MCL pts with adequate organ function were eligible. B Introduction: b MCL is incurable with standard chemotherapy. Venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR) in relapsed/refractory (R/R) and treatment-naïve (TN) mantle cell lymphoma (MCL). [Extracted from the article]

Published
2023
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21. PHASE 2 STUDY OF IBRUTINIB WITH TEMOZOLOMIDE, ETOPOSIDE, LIPOSOMAL DOXORUBICIN, DEXAMETHASONE, RITUXIMAB (TEDDI‐R) FOR SECONDARY CNS LYMPHOMA.

Author

Roschewski, M., Simard, J., Melani, C., Lakhotia, R., Phelan, J. D., Pittaluga, S., Muppidi, J. R., Lionakis, M. S., Peer, C., Pradhan, A., Holdhoff, M., Swinnen, L. J., Dunleavy, K., Lai, C., Ibrahimi, S., Glantz, M., Butman, J. A., Johnson, K., Steinberg, S. M., and Figg, W. D.

Subjects
TEMOZOLOMIDE, RITUXIMAB, DOXORUBICIN, LYMPHOMAS, ETOPOSIDE
Abstract

Pts with >=20% reduction after ibrutinib received TEDDi-R; those with <20% reduction received TEDD-R. Therapy was 4 cycles × 21d with IT therapy (no maintenance) and mostly outpatient. The 1-year PFS and OS for pts with CD10 neg tumors was 48.0% and 64.7% B Conclusions: b Ibrutinib-responsive SCNSL achieves high rates of CR to TEDDi-R that can be durable. Ibrutinib-responsive tumors are mostly CD10 negative and TEDDi-R may improve the outcomes of this subgroup. [Extracted from the article]

Published
2023
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33. Adaptive environmental sampling: The interplay between geostatistics and geometry

Author

Berretta, S., Cabiddu, D., Pittaluga, S., Mortara, M., Spagnuolo, M., and Zuccolini, M. Vetuschi

Subjects
N/A
Abstract

In environmental surveys a large sampling effort is required to produce accurate geostatistical maps representing the distribution of environmental variables, and the analysis of each sample is often expensive. Typically, the sample locations are completely specified in the survey design phase, prior to data-collection. Usually, the sampling points are located on a regular grid, or along directions that are selected with respect to any a-priori knowledge of the expert. No feedback is available during the survey. In this paper, we present a different sampling strategy, namely adaptive sampling. Our approach exploits geostatistics constructs in order to determine on-the fly the next best sample location. After initializing the system with few sampling points, an iterative routine predicts the variable distribution from the data sampled so far, and suggests the next sample to be acquired in order to optimize the uncertainty of the estimates. At every iteration a new sample is acquired, and the variable distribution map is refined, along with the uncertainty map related to that distribution. Our method allows to build a representation of the survey area as precise as the one provided by the traditional methods, but with less samples, thus reducing both time and costs of the survey. We show a preliminary evaluation of the adaptive strategy in the bi-dimensional case based on a synthetic scenario, and describe the generalization of these encouraging results to the full 3D domain in the concrete setting of water quality monitoring. A proper geometric representation of the three dimensional survey area, coupled with a proper visualization of distribution and related uncertainty, will provide real-time feedback during the survey., Smart Tools and Apps for Graphics - Eurographics Italian Chapter Conference, Computer Graphics and its Applications, 133, 140, S. Berretta, D. Cabiddu, S. Pittaluga, M. Mortara, M. Spagnuolo, and M. Vetuschi Zuccolini

Published
2018

35. PHASE 1B STUDY OF ViPOR (VENETOCLAX, IBRUTINIB, PREDNISONE, OBINUTUZUMAB, LENALIDOMIDE) IN RELAPSED/REFRACTORY B-CELL LYMPHOMA: SAFETY, EFFICACY AND MOLECULAR ANALYSIS

Author

Melani, C.J., primary, Lakhotia, R., additional, Pittaluga, S., additional, Miljkovic, M.D., additional, Portell, C.A., additional, Farah, R.J., additional, Juanitez, A.M., additional, Chou, L.L., additional, Steinberg, S.M., additional, Jaffe, E.S., additional, Staudt, L.M., additional, Roschewski, M.J., additional, and Wilson, W.H., additional

Published
2019
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38. Double-cavity open permanent magnet for dedicated MRI

Author

Trequattrini, A., Coscia, G., and Pittaluga, s.

Subjects
Magnetic resonance imaging -- Research, Magnets -- Design and construction, Business, Electronics, Electronics and electrical industries
Abstract

The main features of a new 0.2 T magnetic structure for dedicated magnetic resonance imaging are examined including the magnetic circuit based on rare earth permanent magnets, split pole plate design and ergonomic cavity shape.

Published
2000

41. Multifactorial Regulation of the Human c-myc Oncogene

Author

Zajac-Kaye, M., Avigan, M., Takimoto, M., Pittaluga, S., Quinn, J., Gelmann, E., Levens, D., Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, McConell, I., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, Potter, Michael, editor, and Melchers, Fritz, editor

Published
1988
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44. Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma.

Author

Melani, C., Lakhotia, R., Pittaluga, S., Phelan, J. D., Huang, D. W., Wright, G., Simard, J., Muppidi, J., Thomas, C. J., Ceribelli, M., Tosto, F. A., Yang, Y., Xu, W., Davies-Hill, T., Pack, S. D., Peer, C. J., Arisa, O., Mena, E., Lindenberg, L., and Bergvall, E.

Subjects
*CIRCULATING tumor DNA, *POISONS, *DIFFUSE large B-cell lymphomas, *FEBRILE neutropenia, *INTRACRANIAL hemorrhage
Abstract

BACKGROUND The identification of oncogenic mutations in diffuse large B-cell lymphoma (DLBCL) has led to the development of drugs that target essential survival pathways, but whether targeting multiple survival pathways may be curative in DLBCL is unknown. METHODS We performed a single-center, phase 1b-2 study of a regimen of venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR) in relapsed or refractory DLBCL. In phase 1b, which included patients with DLBCL and indolent lymphomas, four dose levels of venetoclax were evaluated to identify the recommended phase 2 dose, with fixed doses of the other four drugs. A phase 2 expansion in patients with germinal-center B-cell (GCB) and non-GCB DLBCL was performed. ViPOR was administered every 21 days for six cycles. RESULTS In phase 1b of the study, involving 20 patients (10 with DLBCL), a single dose-limiting toxic effect of grade 3 intracranial hemorrhage occurred, a result that established venetoclax at a dose of 800 mg as the recommended phase 2 dose. Phase 2 included 40 patients with DLBCL. Toxic effects that were observed among all the patients included grade 3 or 4 neutropenia (in 24% of the cycles), thrombocytopenia (in 23%), anemia (in 7%), and febrile neutropenia (in 1%). Objective responses occurred in 54% of 48 evaluable patients with DLBCL, and complete responses occurred in 38%; complete responses were exclusively in patients with non-GCB DLBCL and high-grade B-cell lymphoma with rearrangements of MYC and BCL2 or BCL6 (or both). Circulating tumor DNA was undetectable in 33% of the patients at the end of ViPOR therapy. With a median follow-up of 40 months, 2-year progression-free survival and overall survival were 34% (95% confidence interval [CI], 21 to 47) and 36% (95% CI, 23 to 49), respectively. CONCLUSIONS Treatment with ViPOR was associated with durable remissions in patients with specific molecular DLBCL subtypes and was associated with mainly reversible adverse events. (Funded by the Intramural Research Program of the National Cancer Institute and the National Center for Advancing Translational Sciences of the National Institutes of Health and others; ClinicalTrials.gov number, NCT03223610.) [ABSTRACT FROM AUTHOR]

Published
2024
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45. Identification of a subset of perpheral T-cell lymphoma, not otherwise specified, characterized by FOXP3-positive regulatory T-cell phenotype, HTLV-1 negativity and poor outcome.:Identification of a subset of perpheral T-cell lymphoma, not otherwise specified, characterized by FOXP3-positive regulatory T-cell phenotype, HTLV-1 negativity and poor outcome

Author

Pedersen, Martin Bjerregård, Hamilton-Dutoit, Stephen Jacques, Bendix, Knud, Møller, Michael Boe, Raffeld, Mark, Pittaluga, S, Steiniche, Torben, Bergmann, A., Vater, Inga, Siebert, Reiner, Chan, Wing C, and D'Amore, Francesco Annibale

Subjects
immune system diseases, hemic and lymphatic diseases
Abstract

Identification of a subset of perpheral T-cell lymphoma, not otherwise specified, characterized by FOXP3-positive regulatory T-cell phenotype, HTLV-1 negativity and poor outcome.

Published
2014

47. Immune-checkpoint expression in Epstein-Barr virus positive and negative plasmablastic lymphoma: a clinical and pathological study in 82 patients

Author

Laurent, C., primary, Fabiani, B., additional, Do, C., additional, Tchernonog, E., additional, Cartron, G., additional, Gravelle, P., additional, Amara, N., additional, Malot, S., additional, Palisoc, M. M., additional, Copie-Bergman, C., additional, Glehen, A. T., additional, Copin, M.-C., additional, Brousset, P., additional, Pittaluga, S., additional, Jaffe, E. S., additional, and Coppo, P., additional

Published
2016
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