Search

Your search keyword '"Pitsiladis, Yannis P"' showing total 706 results
Start Over Author "Pitsiladis, Yannis P"
706 results on '"Pitsiladis, Yannis P"'

1. Greater male variability in daily energy expenditure develops through puberty.

Author

Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty, Kimura, Misaka, Kraus, William, Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert, Lambert, Estelle, Lanerolle, Pulani, Larsson, Christel, Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin, Morehen, James, Morton, James, Must, Aviva, Neuheuser, Marian, Nicklas, Theresa, Ojiambo, Robert, Pietilainen, Kirsi, Pitsiladis, Yannis, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross, Rabinovich, Roberto, Racette, Susan, Raichen, David, Ravussin, Eric, Redman, Leanne, Reilly, John, Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer, Samaranayake, Dulani, Sardinha, Luís, Scuitt, Albertine, Silva, Analiza, Sinha, Srishti, Sjödin, Anders, Stice, Eric, Stunkard, Albert, Urlacher, Samuel, Valencia, Mauro, Valenti, Giulio, van Etten, Ludo, Van Mil, Edgar, Verbunt, Jeanine, Wells, Jonathan, Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Sagayama, Hiroyuki, Westerterp, Klaas, Wong, William, Yamada, Yosuke, Speakman, John, Halsey, Lewis, Careau, Vincent, Ainslie, Philip, Alemán-Mateo, Heliodoro, Andersen, Lene, Anderson, Liam, Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn, Bovet, Pascal, Brage, Soren, Buchowski, Maciej, Butte, Nancy, Camps, Stephan, Casper, Regian, Close, Graeme, Colbert, Lisa, Cooper, Jamie, Cooper, Richard, Dabare, Prasangi, Das, Sai, Davies, Peter, Deb, Sanjoy, and Nyström, Christine

Subjects
age, height, inter-individual variation, morphometry, weight, Adolescent, Young Adult, Female, Humans, Male, Adult, Puberty, Sexual Behavior, Reproduction, Energy Metabolism, Phenotype
Abstract

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass. Total EE, and to some degree also activity EE, exhibit considerable greater male variation (GMV) in young adults, and then a decreasing GMV in progressively older individuals. Arguably, basal EE, and also morphometrics, do not exhibit this pattern. These findings suggest that single male sexual characteristics may not exhibit peak GMV in young adulthood, however total and perhaps also activity EE, associated with many morphological and physiological traits combined, do exhibit GMV most prominently during the reproductive life stages.

Published
2023

4. Technology Innovation and Guardrails in Elite Sport: The Future is Now

Author

Guppy, Fergus, Muniz-Pardos, Borja, Angeloudis, Konstantinos, Grivas, Gerasimos V., Pitsiladis, Asimina, Bundy, Ross, Zelenkova, Irina, Tanisawa, Kumpei, Akiyama, Hiroshi, Keramitsoglou, Iphigenia, Miller, Mike, Knopp, Melanie, Schweizer, Fabian, Luckfiel, Tobias, Ruiz, Daniel, Racinais, Sebastien, and Pitsiladis, Yannis

Published
2023
Full Text
View/download PDF

5. Variation in human water turnover associated with environmental and lifestyle factors

Author

Yamada, Yosuke, Zhang, Xueying, Henderson, Mary ET, Sagayama, Hiroyuki, Pontzer, Herman, Watanabe, Daiki, Yoshida, Tsukasa, Kimura, Misaka, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Close, Graeme L, Cooper, Jamie A, Cooper, Richard, Das, Sai Krupa, Dugas, Lara R, Eaton, Simon, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Halsey, Lewis G, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kraus, William E, Kriengsinyos, Wantanee, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Redman, Leanne M, Reilly, John J, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sardinha, Luis B, Silva, Analiza M, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack A, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Westerterp, Klaas R, Wong, William W, Miyachi, Motohiko, Schoeller, Dale A, Speakman, John R, and Consortium§, International Atomic Energy Agency Doubly Labeled Water Database

Subjects
Prevention, Clean Water and Sanitation, Female, Humans, Pregnancy, Exercise, Humidity, Life Style, Social Class, Water, Infant, Newborn, Infant, Child, Preschool, Child, Adolescent, Young Adult, Adult, Middle Aged, Aged, Aged, 80 and over, Drinking, International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium§, General Science & Technology
Abstract

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

Published
2022

6. Variability in energy expenditure is much greater in males than females

Author

Halsey, Lewis G, Careau, Vincent, Pontzer, Herman, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Yamada, Yosuke, and Speakman, John R

Subjects
Obesity, Behavioral and Social Science, Affordable and Clean Energy, Adult, Aged, Aging, Animals, Body Composition, Energy Metabolism, Female, Humans, Male, Mammals, Reproduction, Sex Characteristics, DLW, Energetics, Activity, Trait variability, Biological sex, Evolutionary Biology, Anthropology, Archaeology
Abstract

In mammals, trait variation is often reported to be greater among males than females. However, to date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behavioral traits. Energy expenditure could exhibit particularly high greater male variation through a cumulative effect if those traits mostly exhibit greater male variation, or a lack of greater male variation if many of them do not. Sex differences in energy expenditure variation have been little explored. We analyzed a large database on energy expenditure in adult humans (1494 males and 3108 females) to investigate whether humans have evolved sex differences in the degree of interindividual variation in energy expenditure. We found that, even when statistically comparing males and females of the same age, height, and body composition, there is much more variation in total, activity, and basal energy expenditure among males. However, with aging, variation in total energy expenditure decreases, and because this happens more rapidly in males, the magnitude of greater male variation, though still large, is attenuated in older age groups. Considerably greater male variation in both total and activity energy expenditure could be explained by greater male variation in levels of daily activity. The considerably greater male variation in basal energy expenditure is remarkable and may be explained, at least in part, by greater male variation in the size of energy-demanding organs. If energy expenditure is a trait that is of indirect interest to females when choosing a sexual partner, this would suggest that energy expenditure is under sexual selection. However, we present a novel energetics model demonstrating that it is also possible that females have been under stabilizing selection pressure for an intermediate basal energy expenditure to maximize energy available for reproduction.

Published
2022

7. Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Author

Zhang, Xueying, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Blaak, Ellen E, Buchowski, Maciej S, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Dugas, Lara R, Gurven, Michael, Hamdouchi, Asmaa El, Hu, Sumei, Joonas, Noorjehan, Katzmarzyk, Peter, Kraus, William E, Kushner, Robert F, Leonard, William R, Martin, Corby K, Meijer, Erwin P, Neuhouser, Marian L, Ojiambo, Robert M, Pitsiladis, Yannis P, Plasqui, Guy, Prentice, Ross L, Racette, Susan B, Ravussin, Eric, Redman, Leanne M, Reynolds, Rebecca M, Roberts, Susan B, Sardinha, Luis B, Silva, Analiza M, Stice, Eric, Urlacher, Samuel S, Van Mil, Edgar A, Wood, Brian M, Murphy-Alford, Alexia J, Loechl, Cornelia, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Pontzer, Herman, Speakman, John R, consortium, the IAEA DLW database, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Addo, Bedu, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn VC, Bovet, Pascal, Branth, Stefan, De Bruin, Niels C, Butte, Nancy F, Colbert, Lisa H, Camps, Stephan G, Dutman, Alice E, Eaton, Simon D, Ekelund, Ulf, Entringer, Sonja, Ebbeling, Cara, Elmståhl, Sölve, Fogelholm, Mikael, Forrester, Terrence, Fudge, Barry W, Harris, Tamara, Heijligenberg, Rik, Goris, Annelies H, Hambly, Catherine, Hoos, Marije B, Jorgensen, Hans U, Joosen, Annemiek M, Kempen, Kitty P, Kimura, Misaka, Kriengsinyos, Watanee, Lambert, Estelle V, Larsson, Christel L, Lessan, Nader, Ludwig, David S, McCloskey, Margaret, Medin, Anine C, Meijer, Gerwin A, Matsiko, Eric, Melse-Boonstra, Alida, Morehen, James C, Morton, James P, Nicklas, Theresa A, Pannemans, Daphne L, Pietiläinen, Kirsi H, Philippaerts, Renaat M, Rabinovich, Roberto A, Reilly, John J, Rothenberg, Elisabet M, Schuit, Albertine J, Schulz, Sabine, and Sjödin, Anders M

Subjects
Nutrition, IAEA DLW database consortium, Human Physiology, Human activity in medical context, Human metabolism
Abstract

Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW database for adults in the USA (n = 3213) to determine the effect of Ta (-10 to +30°C) on TEE, basal (BEE) and activity energy expenditure (AEE) and physical activity level (PAL). There were no significant relationships (p > 0.05) between maximum, minimum and average Ta and TEE, BEE, AEE and PAL. After adjustment for fat-free mass, fat mass and age, statistically significant (p

Published
2022

8. An observational human study investigating the effect of anabolic androgenic steroid use on the transcriptome of skeletal muscle and whole blood using RNA-Seq

Author

Kolliari-Turner, Alexander, Lima, Giscard, Wang, Guan, Malinsky, Fernanda Rossell, Karanikolou, Antonia, Eichhorn, Gregor, Tanisawa, Kumpei, Ospina-Betancurt, Jonathan, Hamilton, Blair, Kumi, Paulette Y.O., Shurlock, Jonathan, Skiadas, Vasileios, Twycross-Lewis, Richard, Kilduff, Liam, Martin, Renan Paulo, Ash, Garrett I., Potter, Cynthia, Guppy, Fergus M., Seto, Jane T., Fossati, Chiara, Pigozzi, Fabio, Borrione, Paolo, and Pitsiladis, Yannis

Published
2023
Full Text
View/download PDF

10. Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Author

Rimbach, Rebecca, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Anderson, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Speakman, John R, and Pontzer, Herman

Subjects
Nutrition, Pediatric, Clinical Research, Obesity, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Adipose Tissue, Adult, Bayes Theorem, Body Composition, Child, Databases, Factual, Energy Metabolism, Female, Humans, Isotope Labeling, Longitudinal Studies, Male, Middle Aged, Water, Weight Gain, IAEA DLW Database Consortium
Abstract

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.

Published
2022

11. Physical activity and fat-free mass during growth and in later life

Author

Westerterp, Klaas R, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai K, Cooper, Richard, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A, Wong, William W, Speakman, John R, Branth, Stefan, Colbert, Lisa H, De Bruin, Niels C, Dutman, Alice E, Elmståhl, Sölve, Fogelholm, Mikael, Harris, Tamara, Heijligenberg, Rik, Jorgensen, Hans U, Larsson, Christel L, Rothenberg, Elisabet M, McCloskey, Margaret, Meijer, Gerwin A, Pannemans, Daphne L, Schulz, Sabine, Van den Berg-Emons, Rita, Van Gemert, Wim G, and Wilhelmine, W

Subjects
Prevention, Aging, Clinical Research, Nutrition, Adipose Tissue, Adolescent, Adult, Aged, Aged, 80 and over, Body Composition, Child, Child, Preschool, Cross-Sectional Studies, Energy Metabolism, Exercise, Female, Humans, Male, Middle Aged, Young Adult, physical activity level, age, energy expenditure, body composition, doubly labeled water, International Atomic Energy Agency Doubly Labeled Water database group, Engineering, Medical and Health Sciences, Nutrition & Dietetics
Abstract

BackgroundPhysical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass.ObjectivesA study is presented of the association between FFM and physical activity in relation to age.MethodsIn a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution.ResultsPAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males

Published
2021

12. Energy compensation and adiposity in humans

Author

Careau, Vincent, Halsey, Lewis G, Pontzer, Herman, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Eaton, Simon D, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reilly, John J, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A, Wong, William W, Yamada, Yosuke, Speakman, John R, and group, the IAEA DLW database

Subjects
Nutrition, Obesity, Clinical Research, Oral and gastrointestinal, Stroke, Metabolic and endocrine, Cancer, Cardiovascular, Affordable and Clean Energy, Adiposity, Energy Intake, Energy Metabolism, Humans, IAEA DLW database group, Homo sapiens, activity, basal metabolic rate, daily energy expenditure, energy compensation, energy management models, exercise, trade-offs, weight loss, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology
Abstract

Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.1-3 This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response-energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories we burn from additional activity translates into extra calories burned that day. Moreover, the degree of energy compensation varied considerably between people of different body compositions. This association between compensation and adiposity could be due to among-individual differences in compensation: people who compensate more may be more likely to accumulate body fat. Alternatively, the process might occur within individuals: as we get fatter, our body might compensate more strongly for the calories burned during activity, making losing fat progressively more difficult. Determining the causality of the relationship between energy compensation and adiposity will be key to improving public health strategies regarding obesity.

Published
2021

13. Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method

Author

Wong, William W, Speakman, John R, Ainslie, Philip N, Anderson, Liam J, Arab, Leonore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Casper, Regina, Close, Graeme L, Colbert, Lisa H, Cooper, Jamie A, Das, Sai K, Davies, Peter SW, Eaton, Simon, Ekelund, Ulf, Hambly, Catherine, El Hamdouchi, Asmaa, Entringer, Sonja, Fudge, Barry W, Gillingham, Melanie, Goris, Annelies H, Gurven, Micheal, Hoos, Marije B, Hu, Sumei, Joosen, Annemiek, Katzmarzyk, Peter T, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Larsson, Christel L, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietilainen, Kirsi H, Pitsiladis, Yannis P, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto, Racette, Susan B, Raichen, David A, Redman, Leanne, Ravussin, Eric, Reilly, John J, Roberts, Susan, Scuitt, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, van Etten, Ludo M, Van Mil, Edgar A, Verbunt, Jeanine A, Wells, Jonathan CK, Wilson, George, Yoshida, Tsukasa, Zhang, Xueying, Loechl, Cornelia U, Luke, Amy, Murphy-Alford, Alexia J, Pontzer, Herman, Sagayama, Hiroyuki, Rood, Jennifer C, Schoeller, Dale A, Westerterp, Klaas R, and Yamada, Yosuke

Published
2024
Full Text
View/download PDF

14. Daily energy expenditure through the human life course

Author

Pontzer, Herman, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Close, Graeme L, Cooper, Jamie A, Cooper, Richard, Das, Sai Krupa, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marjije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Teresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Speakman, John R, and Consortium§, IAEA DLW Database

Subjects
Aging, Nutrition, Adolescent, Adult, Aged, Aged, 80 and over, Basal Metabolism, Body Composition, Body Weight, Child, Child, Preschool, Energy Metabolism, Exercise, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Pregnancy, Young Adult, IAEA DLW Database Consortium, General Science & Technology
Abstract

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Published
2021

15. A standard calculation methodology for human doubly labeled water studies.

Author

Speakman, John R, Yamada, Yosuke, Sagayama, Hiroyuki, Berman, Elena SF, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Creasy, Seth A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Ebbeling, Cara B, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Ludwig, David S, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Melanson, Edward L, Luke, Amy H, Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, and IAEA DLW database group

Subjects
IAEA DLW database group, doubly labeled water, free-living, total energy expenditure, validation
Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (

Published
2021

19. Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Author

Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issad, Addo, Bedu, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn V.C., Bovet, Pascal, Branth, Stefan, De Bruin, Niels C., Butte, Nancy F., Colbert, Lisa H., Camps, Stephan G., Dutman, Alice E., Eaton, Simon D., Ekelund, Ulf, Entringer, Sonja, Ebbeling, Cara, Elmståhl, Sölve, Fogelholm, Mikael, Forrester, Terrence, Fudge, Barry W., Harris, Tamara, Heijligenberg, Rik, Goris, Annelies H., Hambly, Catherine, Hoos, Marije B., Jorgensen, Hans U., Joosen, Annemiek M., Kempen, Kitty P., Kimura, Misaka, Kriengsinyos, Watanee, Lambert, Estelle V., Larsson, Christel L., Lessan, Nader, Ludwig, David S., McCloskey, Margaret, Medin, Anine C., Meijer, Gerwin A., Matsiko, Eric, Melse-Boonstra, Alida, Morehen, James C., Morton, James P., Nicklas, Theresa A., Pannemans, Daphne L., Pietiläinen, Kirsi H., Philippaerts, Renaat M., Rabinovich, Roberto A., Reilly, John J., Rothenberg, Elisabet M., Schuit, Albertine J., Schulz, Sabine, Sjödin, Anders M., Subar, Amy, Tanskanen, Minna, Uauy, Ricardo, Valenti, Giulio, Van Etten, Ludo M., Berg-Emons, Rita Van den, Van Gemert, Wim G., Velthuis-te Wierik, Erica J., Verboeket-van de Venne, Wilhelmine W., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Zhang, Xueying, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N., Blaak, Ellen E., Buchowski, Maciej S., Close, Graeme L., Cooper, Jamie A., Das, Sai Krupa, Dugas, Lara R., Gurven, Michael, El Hamdouchi, Asmaa, Hu, Sumei, Joonas, Noorjehan, Katzmarzyk, Peter, Kraus, William E., Kushner, Robert F., Leonard, William R., Martin, Corby K., Meijer, Erwin P., Neuhouser, Marian L., Ojiambo, Robert M., Pitsiladis, Yannis P., Plasqui, Guy, Prentice, Ross L., Racette, Susan B., Ravussin, Eric, Redman, Leanne M., Reynolds, Rebecca M., Roberts, Susan B., Sardinha, Luis B., Silva, Analiza M., Stice, Eric, Urlacher, Samuel S., Van Mil, Edgar A., Wood, Brian M., Murphy-Alford, Alexia J., Loechl, Cornelia, Luke, Amy H., Rood, Jennifer, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W., Pontzer, Herman, and Speakman, John R.

Published
2022
Full Text
View/download PDF

24. Establishing a Global Standard for Wearable Devices in Sport and Exercise Medicine: Perspectives from Academic and Industry Stakeholders

Author

Ash, Garrett I., Stults-Kolehmainen, Matthew, Busa, Michael A., Gaffey, Allison E., Angeloudis, Konstantinos, Muniz-Pardos, Borja, Gregory, Robert, Huggins, Robert A., Redeker, Nancy S., Weinzimer, Stuart A., Grieco, Lauren A., Lyden, Kate, Megally, Esmeralda, Vogiatzis, Ioannis, Scher, LaurieAnn, Zhu, Xinxin, Baker, Julien S., Brandt, Cynthia, Businelle, Michael S., Fucito, Lisa M., Griggs, Stephanie, Jarrin, Robert, Mortazavi, Bobak J., Prioleau, Temiloluwa, Roberts, Walter, Spanakis, Elias K., Nally, Laura M., Debruyne, Andre, Bachl, Norbert, Pigozzi, Fabio, Halabchi, Farzin, Ramagole, Dimakatso A., Janse van Rensburg, Dina C., Wolfarth, Bernd, Fossati, Chiara, Rozenstoka, Sandra, Tanisawa, Kumpei, Börjesson, Mats, Casajus, José Antonio, Gonzalez-Aguero, Alex, Zelenkova, Irina, Swart, Jeroen, Gursoy, Gamze, Meyerson, William, Liu, Jason, Greenbaum, Dov, Pitsiladis, Yannis P., and Gerstein, Mark B.

Published
2021
Full Text
View/download PDF

26. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Author

Willems, Sara M, Wright, Daniel J, Day, Felix R, Trajanoska, Katerina, Joshi, Peter K, Morris, John A, Matteini, Amy M, Garton, Fleur C, Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J, Lotta, Luca A, Miyamoto-Mikami, Eri, Rivas, Manuel A, White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R, Austin, Krista, Benyamin, Beben, Brage, Søren, Cheng, Yu-Ching, Cięszczyk, Paweł, Derave, Wim, Eriksson, Karl-Fredrik, Eynon, Nir, Linneberg, Allan, Lucia, Alejandro, Massidda, Myosotis, Mitchell, Braxton D, Miyachi, Motohiko, Murakami, Haruka, Padmanabhan, Sandosh, Pandey, Ashutosh, Papadimitriou, Ioannis, Rajpal, Deepak K, Sale, Craig, Schnurr, Theresia M, Sessa, Francesco, Shrine, Nick, Tobin, Martin D, Varley, Ian, Wain, Louise V, Wray, Naomi R, Lindgren, Cecilia M, MacArthur, Daniel G, Waterworth, Dawn M, McCarthy, Mark I, Pedersen, Oluf, Khaw, Kay-Tee, Kiel, Douglas P, GEFOS Any-Type of Fracture Consortium, Pitsiladis, Yannis, Fuku, Noriyuki, Franks, Paul W, North, Kathryn N, van Duijn, Cornelia M, Mather, Karen A, Hansen, Torben, Hansson, Ola, Spector, Tim, Murabito, Joanne M, Richards, J Brent, Rivadeneira, Fernando, Langenberg, Claudia, Perry, John RB, Wareham, Nick J, and Scott, Robert A

Subjects
GEFOS Any-Type of Fracture Consortium, Hand, Humans, Actins, Transforming Growth Factor alpha, Membrane Proteins, Neoplasm Proteins, Nuclear Proteins, Repressor Proteins, Hand Strength, Cohort Studies, Genetics, Population, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, European Continental Ancestry Group, Female, Male, Genome-Wide Association Study, Genetic Loci, United Kingdom, Prevention, Genetics, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Musculoskeletal
Abstract

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P

Published
2017

27. Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement

Author

Hamilton, Blair R., Lima, Giscard, Barrett, James, Seal, Leighton, Kolliari-Turner, Alexander, Wang, Guan, Karanikolou, Antonia, Bigard, Xavier, Löllgen, Herbert, Zupet, Petra, Ionescu, Anca, Debruyne, Andre, Jones, Nigel, Vonbank, Karin, Fagnani, Federica, Fossati, Chiara, Casasco, Maurizio, Constantinou, Demitri, Wolfarth, Bernd, Niederseer, David, Bosch, Andrew, Muniz-Pardos, Borja, Casajus, José Antonio, Schneider, Christian, Loland, Sigmund, Verroken, Michele, Marqueta, Pedro Manonelles, Arroyo, Francisco, Pedrinelli, André, Natsis, Konstantinos, Verhagen, Evert, Roberts, William O., Lazzoli, José Kawazoe, Friedman, Rogerio, Erdogan, Ali, Cintron, Ana V., Yung, Shu-Hang Patrick, Janse van Rensburg, Dina C., Ramagole, Dimakatso A., Rozenstoka, Sandra, Drummond, Felix, Papadopoulou, Theodora, Kumi, Paulette Y. O., Twycross-Lewis, Richard, Harper, Joanna, Skiadas, Vasileios, Shurlock, Jonathan, Tanisawa, Kumpei, Seto, Jane, North, Kathryn, Angadi, Siddhartha S., Martinez-Patiño, Maria Jose, Borjesson, Mats, Di Luigi, Luigi, Dohi, Michiko, Swart, Jeroen, Bilzon, James Lee John, Badtieva, Victoriya, Zelenkova, Irina, Steinacker, Juergen M., Bachl, Norbert, Pigozzi, Fabio, Geistlinger, Michael, Goulis, Dimitrios G., Guppy, Fergus, Webborn, Nick, Yildiz, Bulent O., Miller, Mike, Singleton, Patrick, and Pitsiladis, Yannis P.

Published
2021
Full Text
View/download PDF

28. Response to the United Nations Human Rights Council’s Report on Race and Gender Discrimination in Sport: An Expression of Concern and a Call to Prioritise Research

Author

Hamilton, Blair R., Martinez-Patiño, Maria Jose, Barrett, James, Seal, Leighton, Tucker, Ross, Papadopoulou, Theodora, Bigard, Xavier, Kolliari-Turner, Alexander, Löllgen, Herbert, Zupet, Petra, Ionescu, Anca, Debruyne, Andre, Jones, Nigel, Steinacker, Juergen M., Vonbank, Karin, Lima, Giscard, Fagnani, Federica, Fossati, Chiara, Di Luigi, Luigi, Pigozzi, Fabio, Casasco, Maurizio, Geistlinger, Michael, Wolfarth, Bernd, Seto, Jane T., Bachl, Norbert, Twycross-Lewis, Richard, Niederseer, David, Bosch, Andrew, Swart, Jeroen, Constantinou, Demitri, Muniz-Pardos, Borja, Casajus, José Antonio, Badtieva, Victoriya, Zelenkova, Irina, Bilzon, James L. J., Dohi, Michiko, Schneider, Christian, Loland, Sigmund, Verroken, Michele, Marqueta, Pedro Manonelles, Arroyo, Francisco, Pedrinelli, André, Natsis, Konstantinos, Verhagen, Evert, Roberts, William O., Lazzoli, José Kawazoe, Friedman, Rogerio, Erdogan, Ali, Cintron, Ana V., Yung, Shu-Hang Patrick, van Rensburg, Dina C. Janse, Ramagole, Dimakatso A., Rozenstoka, Sandra, Drummond, Felix, Webborn, Nick, Guppy, Fergus M., and Pitsiladis, Yannis P.

Published
2021
Full Text
View/download PDF

31. We want healthy athletes and fair competition.

Author

Pitsiladis, Yannis P., Pigozzi, Fabio, Geistlinger, Michael, Lazzoli, José Kawazoe, Zahar, Maher, Bachl, Norbert, Marqueta, Pedro Manonelles, Roberts, William O., Braumann, Klaus-Michael, De Rose, Eduardo H., Constantinou, Demitri, Ionescu, Anca, Schneider, Christian, Patrick Shu-Hang Yung, and Bigard, Xavier

Published
2024
Full Text
View/download PDF

34. Recommendations for Face Coverings While Exercising During the COVID-19 Pandemic

Author

Shurlock, Jonathan, Muniz-Pardos, Borja, Tucker, Ross, Bachl, Norbert, Papadopoulou, Theodora, Holloway, Graham, Jones, Nigel, Bigard, Xavier, Vonbank, Karin, Niederseer, David, Meyer, Joachim, Nowak, Dennis, Debruyne, Andre, Zupet, Petra, Löllgen, Herbert, Steinacker, Juergen M., Wolfarth, Bernd, Bilzon, James L. J., Ionescu, Anca, Dohi, Michiko, Swart, Jeroen, Constantinou, Demitri, Badtieva, Victoriya, Zelenkova, Irina, Casasco, Maurizio, Geistlinger, Michael, Fossati, Chiara, Fagnani, Federica, Di Luigi, Luigi, Webborn, Nick, Angeloudis, Konstantinos, Guppy, Fergus M., Singleton, Patrick, Miller, Mike, Pigozzi, Fabio, and Pitsiladis, Yannis P.

Published
2021
Full Text
View/download PDF

36. Correction to: Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement

Author

Hamilton, Blair R., Lima, Giscard, Barrett, James, Seal, Leighton, Kolliari-Turner, Alexander, Wang, Guan, Karanikolou, Antonia, Bigard, Xavier, Löllgen, Herbert, Zupet, Petra, Ionescu, Anca, Debruyne, Andre, Jones, Nigel, Vonbank, Karin, Fagnani, Federica, Fossati, Chiara, Casasco, Maurizio, Constantinou, Demitri, Wolfarth, Bernd, Niederseer, David, Bosch, Andrew, Muniz-Pardos, Borja, Casajus, José Antonio, Schneider, Christian, Loland, Sigmund, Verroken, Michele, Marqueta, Pedro Manonelles, Arroyo, Francisco, Pedrinelli, André, Natsis, Konstantinos, Verhagen, Evert, Roberts, William O., Lazzoli, José Kawazoe, Friedman, Rogerio, Erdogan, Ali, Cintron, Ana V., Yung, Shu-Hang Patrick, Janse van Rensburg, Dina C., Ramagole, Dimakatso A., Rozenstoka, Sandra, Drummond, Felix, Papadopoulou, Theodora, Kumi, Paulette Y. O., Twycross-Lewis, Richard, Harper, Joanna, Skiadas, Vasileios, Shurlock, Jonathan, Tanisawa, Kumpei, Seto, Jane, North, Kathryn, Angadi, Siddhartha S., Martinez-Patiño, Maria Jose, Borjesson, Mats, Di Luigi, Luigi, Dohi, Michiko, Swart, Jeroen, Bilzon, James Lee John, Badtieva, Victoriya, Zelenkova, Irina, Steinacker, Juergen M., Bachl, Norbert, Pigozzi, Fabio, Geistlinger, Michael, Goulis, Dimitrios G., Guppy, Fergus, Webborn, Nick, Yildiz, Bulent O., Miller, Mike, Singleton, Patrick, and Pitsiladis, Yannis P.

Published
2021
Full Text
View/download PDF

37. Global Alliance for the Promotion of Physical Activity: the Hamburg Declaration

Author

Steinacker, Jürgen M, primary, Mechelen, Willem van, additional, Bloch, Wilhelm, additional, Börjesson, Mats, additional, Casasco, Maurizio, additional, Wolfarth, Bernd, additional, Knoke, Carolin, additional, Papadopoulou, Theodora, additional, Wendt, Janine, additional, Al Tunaiji, Hashel, additional, Andresen, Dietrich, additional, Andrieieva, Olena, additional, Bachl, Norbert, additional, Badtieva, Victoriya, additional, Beucher, Friedhelm J, additional, Blauwet, Cheri A, additional, Casajus Mallen, Jose-Antonio, additional, Chang, Ju-Ho, additional, Clénin, German, additional, Constantini, Naama, additional, Constantinou, Demitri, additional, Di Luigi, Luigi, additional, Declercq, Lukas, additional, Doutreleau, Stephane, additional, Drozdovska, Svitlana, additional, Duclos, Martine, additional, Ermolao, Andrea, additional, Fischbach, Thomas, additional, Fischer, Anastasia N, additional, Fossati, Chiara, additional, Franchella, Jeorge, additional, Fulcher, Mark, additional, Galle, Jan C, additional, Gerloff, Christian, additional, Georgiades, Evelina, additional, Gojanovic, Boris, additional, González Gross, Marcela, additional, Grote, Andy, additional, Halle, Martin, additional, Hauner, Hans, additional, Herring, Matthew Payton, additional, Hiura, Mikio, additional, Holze, Kerstin, additional, Huber, Gerhard, additional, Hughes, David, additional, Hutchinson, Mark R., additional, Ionescu, Anca, additional, Janse van Rensburg, Dina Christina, additional, Jegier, Anna, additional, Jones, Natasha, additional, Kappert-Gonther, Kirsten, additional, Kellerer, Monika, additional, Kimura, Yutaka, additional, Kiopa, Agrita, additional, Kladny, Bernd, additional, Koch, Gerhard, additional, Kolle, Elin, additional, Kolt, Greg, additional, Koutedakis, Yiannis, additional, Kress, Stephan, additional, Kriemler, Susi, additional, Kröger, Jens, additional, Kuhn, Christian, additional, Laszlo, Roman, additional, Lehnert, Ralph, additional, Lhuissier, François J, additional, Lüdtke, Kerstin, additional, Makita, Shigeru, additional, Manonelles Marqueta, Pedro, additional, März, Winfried, additional, Micallef-Stafrace, Kirill, additional, Miller, Mike, additional, Moore, Melita, additional, Müller, Erich, additional, Neunhäuserer, Daniel, additional, Onur, I. Renay, additional, Ööpik, Vahur, additional, Perl, Malgorzata, additional, Philippou, Anastassios, additional, Predel, Hans-Georg, additional, Racinais, Sebastien, additional, Raslanas, Algirdas, additional, Reer, Ruediger, additional, Reinhardt, Klaus, additional, Reinsberger, Claus, additional, Rozenstoka, Sandra, additional, Sallis, Robert, additional, Sardinha, Luis B, additional, Scherer, Martin, additional, Schipperijn, Jasper, additional, Seil, Romain, additional, Tan, Benedict, additional, Schmidt-Trucksäss, Arno, additional, Schumacher, Nils, additional, Schwaab, Bernhard, additional, Schwirtz, Ansgar, additional, Suzuki, Masato, additional, Swart, Jeroen, additional, Tiesler, Ralph, additional, Tippelt, Ulf, additional, Tillet, Eleanor, additional, Thornton, Jane, additional, Ulkar, Bulent, additional, Unt, Eve, additional, Verhagen, Evert, additional, Weikert, Thomas, additional, Vettor, Roberto, additional, Zeng, Sheng, additional, Budgett, Richard, additional, Engebretsen, Lars, additional, Erdener, Ugur, additional, Pigozzi, Fabio, additional, and Pitsiladis, Yannis P, additional

Published
2023
Full Text
View/download PDF

38. International Olympic Committee (IOC) consensus paper on sports-related ophthalmology issues in elite sports

Author

Moe, Morten Carstens, primary, Özmert, Emin, additional, Baudouin, Christophe, additional, Binadra, Abhinav, additional, Crafoord, Sven, additional, Jo, Young, additional, Kiratli, Hayyam, additional, Moore, Melita, additional, Pitsiladis, Yannis P, additional, Rolle, Udo, additional, Tan, Ben, additional, Yanik, Özge, additional, Budgett, Richard, additional, Erdener, Ugur, additional, Steffen, Kathrin, additional, and Engbretsen, Lars, additional

Published
2023
Full Text
View/download PDF

40. Collateral Health Issues Derived from the Covid-19 Pandemic

Author

Muniz-Pardos, Borja, Shurlock, Jonathan, Debruyne, Andre, Steinacker, Juergen M., Börjesson, Mats, Wolfarth, Bernd, Bilzon, James L. J., Löllgen, Herbert, Ionescu, Anca, Zupet, Petra, Dohi, Michiko, Swart, Jeroen, Badtieva, Victoriya, Zelenkova, Irina, Casasco, Maurizio, Geistlinger, Michael, Bachl, Norbert, Tsofliou, Fotini, Di Luigi, Luigi, Bigard, Xavier, Papadopoulou, Theodora, Webborn, Nick, Singleton, Patrick, Miller, Mike, Pigozzi, Fabio, and Pitsiladis, Yannis P.

Published
2020
Full Text
View/download PDF

41. Genetic Polymorphisms Related to VO2max Adaptation Are Associated With Elite Rugby Union Status and Competitive Marathon Performance.

Author

Hall, Elliott C.R., Almeida, Sandro S., Heffernan, Shane M., Lockey, Sarah J., Herbert, Adam J., Callus, Peter, Day, Stephen H., Pedlar, Charles R., Kipps, Courtney, Collins, Malcolm, Pitsiladis, Yannis P., Bennett, Mark A., Kilduff, Liam P., Stebbings, Georgina K., Erskine, Robert M., and Williams, Alun G.

Subjects
ENERGY metabolism, AEROBIC exercises, DNA, OXYGEN consumption, LONG-distance running, GENETIC polymorphisms, PHYSICAL training & conditioning, EXERCISE physiology, ALLELES, PHYSIOLOGICAL adaptation, RUGBY football, GENOTYPES, GENOMICS, CHI-squared test, DESCRIPTIVE statistics, ENDURANCE sports, ATHLETIC ability, ODDS ratio
Abstract

Purpose: Genetic polymorphisms have been associated with the adaptation to training in maximal oxygen uptake ( V ˙ O 2 max). However, the genotype distribution of selected polymorphisms in athletic cohorts is unknown, with their influence on performance characteristics also undetermined. This study investigated whether the genotype distributions of 3 polymorphisms previously associated with V ˙ O 2 max training adaptation are associated with elite athlete status and performance characteristics in runners and rugby athletes, competitors for whom aerobic metabolism is important. Methods: Genomic DNA was collected from 732 men including 165 long-distance runners, 212 elite rugby union athletes, and 355 nonathletes. Genotype and allele frequencies of PRDM1 rs10499043 C/T, GRIN3A rs1535628 G/A, and KCNH8 rs4973706 T/C were compared between athletes and nonathletes. Personal-best marathon times in runners, as well as in-game performance variables and playing position, of rugby athletes were analyzed according to genotype. Results: Runners with PRDM1 T alleles recorded marathon times ∼3 minutes faster than CC homozygotes (02:27:55 [00:07:32] h vs 02:31:03 [00:08:24] h, P =.023). Rugby athletes had 1.57 times greater odds of possessing the KCNH8 TT genotype than nonathletes (65.5% vs 54.7%, χ2 = 6.494, P =.013). No other associations were identified. Conclusions: This study is the first to demonstrate that polymorphisms previously associated with V ˙ O 2 max training adaptations in nonathletes are also associated with marathon performance (PRDM1) and elite rugby union status (KCNH8). The genotypes and alleles previously associated with superior endurance-training adaptation appear to be advantageous in long-distance running and achieving elite status in rugby union. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

42. Establishing a Global Standard for Wearable Devices in Sport and Fitness: Perspectives from the New England Chapter of the American College of Sports Medicine Members

Author

Ash, Garrett I., Stults-Kolehmainen, Matthew, Busa, Michael A., Gregory, Robert, Garber, Carol Ewing, Liu, Jason, Gerstein, Mark, Casajus, José Antonio, Gonzalez-Aguero, Alex, Constantinou, Demitri, Geistlinger, Michael, Guppy, Fergus M., Pigozzi, Fabio, and Pitsiladis, Yannis P.

Published
2020
Full Text
View/download PDF

43. The Olympia Declaration

Author

Pitsiladis, Yannis P., Abatzis-Papadopoulos, Manolis, Ali, Nemer, Aggeloudis, Stelios, Atkinson, Caroline, Constandache, Beatrice, Ganus, Yuri, Geladas, Nikos, Giakoumakis, Savvas I., Güner, Rüştü, Howman, David, Lima, Giscard Humberto Oliveira, Khristenko, Evgeny, Koskolou, Maria, Klissouras, Vassilis, Ladikas, Miltos, Loland, Sigmund, McNamee, Michael J., Pardos, Borja Muñiz, Natsis, Konstantinos, Nicholson, Peter, Betancurt, Jonathan Ospina, Angeloudis, Konstantinos, Pappas, Evangelos, Peteraitis, Maksim, Petróczi, Andrea, Papadopoulou, Theodora, Pigozzi, Fabio, Saugy, Martial, Simon, Perikles, Singleton, Patrick, Sizikova, Ekaterina, Sottas, Pierre-Edouard, Tanaka, Masashi, Wang, Guan, and Yang, Huanming

Published
2019
Full Text
View/download PDF

45. Global Alliance for the Promotion of Physical Activity: the Hamburg Declaration

Author

Steinacker, Jürgen M, Mechelen, Willem van, Bloch, Wilhelm, Börjesson, Mats, Casasco, Maurizio, Wolfarth, Bernd, Knoke, Carolin, Papadopoulou, Theodora, Wendt, Janine, Al Tunaiji, Hashel, Andresen, Dietrich, Andrieieva, Olena, Bachl, Norbert, Badtieva, Victoriya, Beucher, Friedhelm J, Blauwet, Cheri A, Casajus Mallen, Jose-Antonio, Chang, Ju-Ho, Clénin, German, Constantini, Naama, Constantinou, Demitri, Di Luigi, Luigi, Declercq, Lukas, Doutreleau, Stephane, Drozdovska, Svitlana, Duclos, Martine, Ermolao, Andrea, Fischbach, Thomas, Fischer, Anastasia N, Fossati, Chiara, Franchella, Jeorge, Fulcher, Mark, Galle, Jan C, Gerloff, Christian, Georgiades, Evelina, Gojanovic, Boris, González Gross, Marcela, Grote, Andy, Halle, Martin, Hauner, Hans, Herring, Matthew Payton, Hiura, Mikio, Holze, Kerstin, Huber, Gerhard, Hughes, David, Hutchinson, Mark R., Ionescu, Anca, Janse van Rensburg, Dina Christina, Jegier, Anna, Jones, Natasha, Kappert-Gonther, Kirsten, Kellerer, Monika, Kimura, Yutaka, Kiopa, Agrita, Kladny, Bernd, Koch, Gerhard, Kolle, Elin, Kolt, Greg, Koutedakis, Yiannis, Kress, Stephan, Kriemler, Susi, Kröger, Jens, Kuhn, Christian, Laszlo, Roman, Lehnert, Ralph, Lhuissier, François J, Lüdtke, Kerstin, Makita, Shigeru, Manonelles Marqueta, Pedro, März, Winfried, Micallef-Stafrace, Kirill, Miller, Mike, Moore, Melita, Müller, Erich, Neunhäuserer, Daniel, Onur, I. Renay, Ööpik, Vahur, Perl, Malgorzata, Philippou, Anastassios, Predel, Hans-Georg, Racinais, Sebastien, Raslanas, Algirdas, Reer, Ruediger, Reinhardt, Klaus, Reinsberger, Claus, Rozenstoka, Sandra, Sallis, Robert, Sardinha, Luis B, Scherer, Martin, Schipperijn, Jasper, Seil, Romain, Tan, Benedict, Schmidt-Trucksäss, Arno, Schumacher, Nils, Schwaab, Bernhard, Schwirtz, Ansgar, Suzuki, Masato, Swart, Jeroen, Tiesler, Ralph, Tippelt, Ulf, Tillet, Eleanor, Thornton, Jane, Ulkar, Bulent, Unt, Eve, Verhagen, Evert, Weikert, Thomas, Vettor, Roberto, Zeng, Sheng, Budgett, Richard, Engebretsen, Lars, Erdener, Ugur, Pigozzi, Fabio, Pitsiladis, Yannis P, Steinacker, Jürgen M, Mechelen, Willem van, Bloch, Wilhelm, Börjesson, Mats, Casasco, Maurizio, Wolfarth, Bernd, Knoke, Carolin, Papadopoulou, Theodora, Wendt, Janine, Al Tunaiji, Hashel, Andresen, Dietrich, Andrieieva, Olena, Bachl, Norbert, Badtieva, Victoriya, Beucher, Friedhelm J, Blauwet, Cheri A, Casajus Mallen, Jose-Antonio, Chang, Ju-Ho, Clénin, German, Constantini, Naama, Constantinou, Demitri, Di Luigi, Luigi, Declercq, Lukas, Doutreleau, Stephane, Drozdovska, Svitlana, Duclos, Martine, Ermolao, Andrea, Fischbach, Thomas, Fischer, Anastasia N, Fossati, Chiara, Franchella, Jeorge, Fulcher, Mark, Galle, Jan C, Gerloff, Christian, Georgiades, Evelina, Gojanovic, Boris, González Gross, Marcela, Grote, Andy, Halle, Martin, Hauner, Hans, Herring, Matthew Payton, Hiura, Mikio, Holze, Kerstin, Huber, Gerhard, Hughes, David, Hutchinson, Mark R., Ionescu, Anca, Janse van Rensburg, Dina Christina, Jegier, Anna, Jones, Natasha, Kappert-Gonther, Kirsten, Kellerer, Monika, Kimura, Yutaka, Kiopa, Agrita, Kladny, Bernd, Koch, Gerhard, Kolle, Elin, Kolt, Greg, Koutedakis, Yiannis, Kress, Stephan, Kriemler, Susi, Kröger, Jens, Kuhn, Christian, Laszlo, Roman, Lehnert, Ralph, Lhuissier, François J, Lüdtke, Kerstin, Makita, Shigeru, Manonelles Marqueta, Pedro, März, Winfried, Micallef-Stafrace, Kirill, Miller, Mike, Moore, Melita, Müller, Erich, Neunhäuserer, Daniel, Onur, I. Renay, Ööpik, Vahur, Perl, Malgorzata, Philippou, Anastassios, Predel, Hans-Georg, Racinais, Sebastien, Raslanas, Algirdas, Reer, Ruediger, Reinhardt, Klaus, Reinsberger, Claus, Rozenstoka, Sandra, Sallis, Robert, Sardinha, Luis B, Scherer, Martin, Schipperijn, Jasper, Seil, Romain, Tan, Benedict, Schmidt-Trucksäss, Arno, Schumacher, Nils, Schwaab, Bernhard, Schwirtz, Ansgar, Suzuki, Masato, Swart, Jeroen, Tiesler, Ralph, Tippelt, Ulf, Tillet, Eleanor, Thornton, Jane, Ulkar, Bulent, Unt, Eve, Verhagen, Evert, Weikert, Thomas, Vettor, Roberto, Zeng, Sheng, Budgett, Richard, Engebretsen, Lars, Erdener, Ugur, Pigozzi, Fabio, and Pitsiladis, Yannis P

Abstract

Non-communicable diseases (NCDs), including coronary heart disease, stroke, hypertension, type 2 diabetes, dementia, depression and cancers, are on the rise worldwide and are often associated with a lack of physical activity (PA). Globally, the levels of PA among individuals are below WHO recommendations. A lack of PA can increase morbidity and mortality, worsen the quality of life and increase the economic burden on individuals and society. In response to this trend, numerous organisations came together under one umbrella in Hamburg, Germany, in April 2021 and signed the ‘Hamburg Declaration’. This represented an international commitment to take all necessary actions to increase PA and improve the health of individuals to entire communities. Individuals and organisations are working together as the ‘Global Alliance for the Promotion of Physical Activity’ to drive long-term individual and population-wide behaviour change by collaborating with all stakeholders in the community: active hospitals, physical activity specialists, community services and healthcare providers, all achieving sustainable health goals for their patients/clients. The ‘Hamburg Declaration’ calls on national and international policymakers to take concrete action to promote daily PA and exercise at a population level and in healthcare settings., Peer Reviewed

Published
2023

46. The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance

Author

Hall, Elliott CR, Lockey, Sarah J, Heffernan, Shane M, Herbert, Adam J, Stebbings, Georgina K, Day, Stephen H, Collins, Malcolm, Pitsiladis, Yannis P, Erskine, Robert M, Williams, Alun G, Hall, Elliott CR, Lockey, Sarah J, Heffernan, Shane M, Herbert, Adam J, Stebbings, Georgina K, Day, Stephen H, Collins, Malcolm, Pitsiladis, Yannis P, Erskine, Robert M, and Williams, Alun G

Abstract

Success in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism has been associated with endurance athlete status and favourable aerobic training adaptations. However, the association of this polymorphism with performance amongst long-distance runners remains unclear. Accordingly, this study investigated whether rs8192678 was associated with elite status and competitive performance of long-distance runners. Genomic DNA from 656 Caucasian participants including 288 long-distance runners (201 men, 87 women) and 368 non-athletes (285 men, 83 women) was analysed. Medians of the 10 best UK times (Top10) for 10 km, half-marathon and marathon races were calculated, with all included athletes having personal best (PB) performances within 20% of Top10 (this study's definition of "elite"). Genotype and allele frequencies were compared between athletes and non-athletes, and athlete PB compared between genotypes. There were no differences in genotype frequency between athletes and non-athletes, but athlete Ser allele carriers were 2.5% faster than Gly/Gly homozygotes (p = 0.030). This study demonstrates that performance differences between elite long-distance runners are associated with rs8192678 genotype, with the Ser allele appearing to enhance performance.

Published
2023

47. Gene Variants Previously Associated with Reduced Soft-tissue Injury Risk: Part 2 - polygenic associations with elite status in rugby

Author

Brazier, Jon, Antrobus, Mark R, Herbert, Adam J, Callus, Peter C, Khanal, Praval, Stebbings, Georgina K, Day, Stephen H, Heffernan, Shane M, Kilduff, Liam P, Bennett, Mark A, Erskine, Robert M, Raleigh, Stuart M, Collins, Malcolm, Pitsiladis, Yannis P, Williams, Alun G, Brazier, Jon, Antrobus, Mark R, Herbert, Adam J, Callus, Peter C, Khanal, Praval, Stebbings, Georgina K, Day, Stephen H, Heffernan, Shane M, Kilduff, Liam P, Bennett, Mark A, Erskine, Robert M, Raleigh, Stuart M, Collins, Malcolm, Pitsiladis, Yannis P, and Williams, Alun G

Abstract

Part 1 of this genetic association series highlighted several genetic variants independently associated with elite status in rugby. However, it is highly likely that the genetic influence on elite status is polygenic due to the interaction of multiple genes. Therefore, the aim of the present study was to investigate whether polygenic profiles of elite rugby athletes differed from non-athletes utilising 13 genetic polymorphisms previously associated with tendon/ligament injury. Total genotype score (TGS) was calculated and multifactor dimensionality reduction (MDR) was used to calculate SNP-SNP epistasis interactions. Based on our elite rugby data from Part 1, mean TGS was significantly higher in elite rugby athletes (52.1 ± 10.7) than non-athletes (48.7 ± 10.8). There were more elite rugby athletes (54%) within the upper TGS quartile, and fewer (46%) within the lower quartile, compared to non-athletes (31% and 69%, respectively; P = 5·10-5), and the TGS was able to distinguish between elite rugby athletes and non-athletes (area under the curve = 0.59; 95% confidence interval 0.55-0.63; P = 9·10-7). Furthermore, MDR identified a three-SNP model of COL5A1 rs12722, COL5A1 rs3196378 and MIR608 rs4919510 that was best able to predict elite athlete status, with a greater frequency of the CC-CC-CC genotype combination in elite rugby athletes (9.8%) than non-athletes (5.3%). We propose that elite rugby athletes possess 'preferable' musculoskeletal soft-tissue injury-associated polygenic profiles that have helped them achieve success in the high injury risk environment of rugby. These data may, in future, have implications for the individual management of musculoskeletal soft-tissue injury.

Published
2023

48. Greater male variability in daily energy expenditure develops through puberty

Author

Halsey, Lewis G., Careau, Vincent, Ainslie, Philip N., Alemán-Mateo, Heliodoro, Andersen, Lene F., Anderson, Liam J., Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Brage, Soren, Buchowski, Maciej S., Butte, Nancy, Camps, Stephan G., Casper, Regian, Close, Graeme L., Colbert, Lisa H., Cooper, Jamie A., Cooper, Richard, Dabare, Prasangi, Das, Sai Krupa, Davies, Peter S.W., Deb, Sanjoy, Nyström, Christine Delisle, Dietz, William, Dugas, Lara R., Eaton, Simon, Ekelund, Ulf, Hamdouchi, Asmaa El, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Gillingham, Melanie, Goris, Annelies H., Gurven, Michael, Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert F., Lambert, Estelle V., Lanerolle, Pulani, Larsson, Christel L., Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin A., Morehen, James C., Morton, James P., Must, Aviva, Neuheuser, Marian, Nicklas, Theresa A., Ojiambo, Robert M., Pietilainen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto, Racette, Susan B., Raichen, David A., Ravussin, Eric, Redman, Leanne, Reilly, John J., Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer C., Samaranayake, Dulani, Sardinha, Luís B., Scuitt, Albertine J., Silva, Analiza M., Sinha, Srishti, Sjödin, Anders M., Stice, Eric, Stunkard, Albert, Urlacher, Samuel S., Valencia, Mauro Eduardo, Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Rood, Jennifer, Sagayama, Hiroyuki, Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, Speakman, John R., Halsey, Lewis G., Careau, Vincent, Ainslie, Philip N., Alemán-Mateo, Heliodoro, Andersen, Lene F., Anderson, Liam J., Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Brage, Soren, Buchowski, Maciej S., Butte, Nancy, Camps, Stephan G., Casper, Regian, Close, Graeme L., Colbert, Lisa H., Cooper, Jamie A., Cooper, Richard, Dabare, Prasangi, Das, Sai Krupa, Davies, Peter S.W., Deb, Sanjoy, Nyström, Christine Delisle, Dietz, William, Dugas, Lara R., Eaton, Simon, Ekelund, Ulf, Hamdouchi, Asmaa El, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Gillingham, Melanie, Goris, Annelies H., Gurven, Michael, Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert F., Lambert, Estelle V., Lanerolle, Pulani, Larsson, Christel L., Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin A., Morehen, James C., Morton, James P., Must, Aviva, Neuheuser, Marian, Nicklas, Theresa A., Ojiambo, Robert M., Pietilainen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto, Racette, Susan B., Raichen, David A., Ravussin, Eric, Redman, Leanne, Reilly, John J., Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer C., Samaranayake, Dulani, Sardinha, Luís B., Scuitt, Albertine J., Silva, Analiza M., Sinha, Srishti, Sjödin, Anders M., Stice, Eric, Stunkard, Albert, Urlacher, Samuel S., Valencia, Mauro Eduardo, Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Rood, Jennifer, Sagayama, Hiroyuki, Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, and Speakman, John R.

Abstract

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass. Total EE, and to some degree also activity EE, exhibit considerable greater male variation (GMV) in young adults, and then a decreasing GMV in progressively older individuals. Arguably, basal EE, and also morphometrics, do not exhibit this pattern. These findings suggest that single male sexual characteristics may not exhibit peak GMV in young adulthood, however total and perhaps also activity EE, associated with many morphological and physiological traits combined, do exhibit GMV most prominently during the reproductive life stages.

Published
2023

49. Diet manipulation, altered fat and carbohydrate metabolism and exercise performance in trained humans

Author

Pitsiladis, Yannis P.

Subjects
610, Medicine
Abstract

The aim of the first two experiments was to determine whether alterations in dietary carbohydrate (CHO) intake would affect performance of high intensity exercise in well-trained individuals. This was achieved by comparing the effects of a 70 and 40% CHO diet on the performance of high intensity exercise lasting approximately 10 min (Experiment 1) or 30 min (Experiment 2). At both exercise intensities, no difference in exercise performance was found. These results demonstrated that moderate changes in diet composition during normal training do not significantly affect performance of high intensity exercise in well-trained individuals. These findings would suggest that total muscle glycogen concentration was not limiting high intensity exercise performance. The higher than normal daily energy intake of the subjects' diet may have adequately compensated for the reduced percentage of CHO on the two low CHO diets. An increased fat oxidation on the low CHO trial may also have contributed to these results. These results do not exclude the possibility that the glycogen content of individual muscle fibres was limiting high intensity exercise performance. The aim of the third experiment was to determine the effects of an exercise and diet regime, which was intended to alter initial muscle glycogen concentration, on the capacity of well-trained individuals to perform prolonged strenuous exercise to exhaustion in the heat and the cold. Exercise capacity in the heat was reduced compared with exercise in the cold, irrespective of diet. The exercise and diet intervention, when aimed at increasing muscle CHO stores, improved exercise capacity both in the heat and in the cold compared with when the intervention was aimed to reducing CHO stores.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results