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32 results on '"Pitanga, Thassila Nogueira"'

1. Role of paraoxonase 1 activity and PON1 gene polymorphisms in sickle cell disease

Author

Menezes, Joelma Figueiredo, Carvalho, Magda Oliveira Seixas, Rocha, Larissa Carneiro, dos Santos, Felipe Miranda, Adorno, Elisângela Vitória, de Souza, Cyntia Cajado, Santiago, Rayra Pereira, da Guarda, Caroline Conceição, de Oliveira, Rodrigo Mota, Figueiredo, Camylla Vilas Boas, Carvalho, Suéllen Pinheiro, Yahouédéhou, Sètondji Cocou Modeste Alexandre, Fiuza, Luciana Magalhães, Adanho, Corynne Stéphanie Ahouefa, Pitanga, Thassila Nogueira, Lyra, Isa Menezes, Nascimento, Valma Maria Lopes, Noronha-Dutra, Alberto Augusto, and Goncalves, Marilda Souza

Published
2023
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2. Pharmacovigilance in Vaccines: Importance, Main Aspects, Perspectives, and Challenges—A Narrative Review.

Author

Hodel, Katharine Valéria Saraiva, Fiuza, Bianca Sampaio Dotto, Conceição, Rodrigo Souza, Aleluia, Augusto Cezar Magalhães, Pitanga, Thassila Nogueira, Fonseca, Larissa Moraes dos Santos, Valente, Camila Oliveira, Minafra-Rezende, Cintia Silva, and Machado, Bruna Aparecida Souza

Subjects
VACCINE safety, MEDICAL personnel, TECHNOLOGICAL innovations, VIRAL vaccines, VACCINES, VACCINE hesitancy
Abstract

Pharmacovigilance plays a central role in safeguarding public health by continuously monitoring the safety of vaccines, being critical in a climate of vaccine hesitancy, where public trust is paramount. Pharmacovigilance strategies employed to gather information on adverse events following immunization (AEFIs) include pre-registration data, media reports, clinical trials, and societal reporting. Early detection of AEFIs during clinical trials is crucial for thorough safety analysis and preventing serious reactions once vaccines are deployed. This review highlights the importance of societal reporting, encompassing contributions from community members, healthcare workers, and pharmaceutical companies. Technological advancements such as quick response (QR) codes can facilitate prompt AEFI reporting. While vaccines are demonstrably safe, the possibility of adverse events necessitates continuous post-marketing surveillance. However, underreporting remains a challenge, underscoring the critical role of public engagement in pharmacovigilance. This narrative review comprehensively examines and synthesizes key aspects of virus vaccine pharmacovigilance, with special considerations for specific population groups. We explore applicable legislation, the spectrum of AEFIs associated with major vaccines, and the unique challenges and perspectives surrounding pharmacovigilance in this domain. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Association of laboratory markers and cerebral blood flow among sickle cell anemia children

Author

Adanho, Corynne Stéphanie Ahouéfa, primary, Yahouédéhou, Sètondji Cocou Modeste Alexandre, additional, Santana, Sânzio Silva, additional, Vieira, Camilo, additional, Santiago, Rayra Pereira, additional, de Santana, Jeanne Machado, additional, Pitanga, Thassila Nogueira, additional, Aleluia, Milena Magalhães, additional, Maffili, Vítor Valério, additional, Leite, Ivana Paula Ribeiro, additional, Zanette, Dalila Luciola, additional, Lyra, Isa Menezes, additional, and Goncalves, Marilda Souza, additional

Published
2022
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7. An evaluation of ticagrelor for the treatment of sickle cell anemia

Author

Ribeiro-Filho, Jaime, primary, Yahouédéhou, Sètondji Cocou Modeste Alexandre, additional, Pitanga, Thassila Nogueira, additional, Santana, Sânzio Silva, additional, Adorno, Elisângela Vitória, additional, Barbosa, Cynara Gomes, additional, Ferreira, Júnia Raquel Dutra, additional, Pina, Eugênia Terra Granado, additional, Neres, Joelma Santana dos Santos, additional, Leite, Ivana Paula Ribeiro, additional, Lyra, Isa Menezes, additional, and Goncalves, Marilda Souza, additional

Published
2020
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8. Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin

Author

Santana, Sânzio Silva, primary, Pitanga, Thassila Nogueira, additional, de Santana, Jeanne Machado, additional, Zanette, Dalila Lucíola, additional, Vieira, Jamile de Jesus, additional, Yahouédéhou, Sètondji Cocou Modeste Alexandre, additional, Adanho, Corynne Stéphanie Ahouefa, additional, Viana, Sayonara de Melo, additional, Luz, Nivea Farias, additional, Borges, Valeria Matos, additional, and Goncalves, Marilda Souza, additional

Published
2020
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9. Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients

Author

Santiago, Rayra Pereira, Guarda, Caroline Conceição, Figueiredo, Camylla Vilas Boas, Fiuza, Luciana Magalhaes, Aleluia, Milena Magalhães, Adanho, Corynne Stephanie Ahouefa, Carvalho, Magda Oliveira Seixas, Pitanga, Thassila Nogueira, Zanette, Dalila Luciola, Lyra, Isa Menezes, Nascimento, Valma Maria Lopes, Vercellotti, Gregory M., Belcher, John D., and Goncalves, Marilda Souza

Published
2018
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10. Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association withβSHaplotype in Children with Sickle Cell Anemia

Author

Ndidi, Uche Samuel, primary, Adanho, Corynne Stephanie Ahouefa, additional, Santiago, Rayra Pereira, additional, Yahouédéhou, Sètondji Cocou Modeste Alexandre, additional, Santana, Sânzio Silva, additional, Mafili, Vitor Valério, additional, Pitanga, Thassila Nogueira, additional, Fonseca, Cleverson Alves, additional, Ferreira, Junia Raquel Dutra, additional, Adorno, Elisângela Vitoria, additional, Lyra, Isa Menezes, additional, Adekile, Adekunle D., additional, Barbosa, Cynara Gomes, additional, and Goncalves, Marilda Souza, additional

Published
2019
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12. Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia

Author

Aleluia, Milena Magalhães, primary, da Guarda, Caroline Conceição, additional, Santiago, Rayra Pereira, additional, Fonseca, Teresa Cristina Cardoso, additional, Neves, Fábia Idalina, additional, de Souza, Regiana Quinto, additional, Farias, Larissa Alves, additional, Pimenta, Felipe Araújo, additional, Fiuza, Luciana Magalhães, additional, Pitanga, Thassila Nogueira, additional, Ferreira, Júnia Raquel Dutra, additional, Adorno, Elisângela Vitória, additional, Cerqueira, Bruno Antônio Veloso, additional, and Gonçalves, Marilda de Souza, additional

Published
2017
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13. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease

Author

Santiago, Rayra Pereira, primary, Vieira, Camilo, additional, Adanho, Corynne Stephanie Ahouefa, additional, Santana, Sanzio Silva, additional, Guarda, Caroline Conceição, additional, Figueiredo, Camylla Vilas Boas, additional, Fiuza, Luciana Magalhães, additional, Pitanga, Thassila Nogueira, additional, Ferreira, Junia Raquel Dutra, additional, Aleluia, Milena Magalhães, additional, Oliveira, Rodrigo Mota, additional, Zanette, Dalila Luciola, additional, Lyra, Isa Menezes, additional, and Goncalves, Marilda Souza, additional

Published
2017
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14. Laboratorial and Genetic Biomarkers Associated to Cerebral Blood Flow Velocity on Hemoglobin SC Disease

Author

Santiago, Rayra Pereira, primary, Vieira, Camilo, additional, Adanho, Corynne Stephanie Ahouefa, additional, Santana, Sanzio Silva, additional, Guarda, Caroline Conceição, additional, Figueiredo, Camylla Vilas Boas, additional, Fiuza, Luciana Magalhaes, additional, Pitanga, Thassila Nogueira, additional, Ferreira, Junia Raquel Dutra, additional, Aleluia, Milena Magalhães, additional, Mota, Rodrigo Oliveira, additional, Zanette, Dalila Luciola, additional, Lyra, Isa Menezes, additional, and Goncalves, Marilda Souza, additional

Published
2016
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15. Influence of Hydroxyurea on Neutrophil Microparticles: A SCA Model

Author

Pitanga, Thassila Nogueira, primary, Santiago, Rayra Pereira, additional, Santana, Sanzio Silva, additional, Guarda, Caroline Conceição, additional, Ferreira, Júnia Raquel Dutra, additional, Maffili, Vitor Valério, additional, Zanette, Dalila Luciola, additional, Lopes, Valma Maria, additional, Oliveira, Ricardo Riccio, additional, Santos, Washington Luis Conrado, additional, and Goncalves, Marilda Souza, additional

Published
2016
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16. Cardiometabolic and Hemostatic Profiles of Women Carriers of Hemoglobin Variants Using Combined Oral Contraceptives

Author

Ferreira, Junia Raquel Dutra, primary, Guarda, Caroline Conceição, additional, Santiago, Rayra Pereira, additional, Rocha, Luane, additional, Ferreira, Jessica SANTOS, additional, Araújo, Luís, additional, Mota, Barbara, additional, Pitanga, Thassila Nogueira, additional, Milena, Milena Magalhães, additional, Carvalho, Magda Seixas, additional, Adorno, Elisangela Vitoria, additional, and Goncalves, Marilda Souza, additional

Published
2016
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17. Toll-like Receptors Gene Expression Is Modulated By Lysed Sickle Red Blood Cells

Author

Pitanga, Thassila Nogueira, primary, Zanette, Dalila Luciola, additional, Guarda, Caroline Conceição, additional, Santiago, Rayra Pereira, additional, Santana, Sanzio Silva, additional, Maffili, Vitor Valério, additional, Ferreira, Junia Raquel Dutra, additional, Figueiredo, Camylla Vilas Boas, additional, Aleluia, Milena Magalhães, additional, Fiuza, Luciana Magalhaes, additional, Lopes, Valma Maria, additional, Oliveira, Ricardo Riccio, additional, and Goncalves, Marilda Souza, additional

Published
2016
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18. Genome Wide Association Study of Sickle Cell Disease Individuals with Stroke Risk

Author

Santiago, Rayra Pereira, primary, Vieira, Camilo, additional, Adanho, Corynne Stephanie Ahouefa, additional, Guarda, Caroline Conceição, additional, Santana, Sanzio Silva, additional, Figueiredo, Camylla Vilas Boas, additional, Aleluia, Milena Magalhães, additional, Pitanga, Thassila Nogueira, additional, Fiuza, Luciana Magalhaes, additional, Maffili, Vitor Valério, additional, Ferreira, Júnia Raquel Dutra, additional, Oliveira, Rodrigo Mota, additional, Lyra, Isa Menezes, additional, Zanette, Dalila Luciola, additional, and Goncalves, Marilda Souza, additional

Published
2016
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19. Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with βS Haplotype in Children with Sickle Cell Anemia.

Author

Ndidi, Uche Samuel, Adanho, Corynne Stephanie Ahouefa, Santiago, Rayra Pereira, Yahouédéhou, Sètondji Cocou Modeste Alexandre, Santana, Sânzio Silva, Mafili, Vitor Valério, Pitanga, Thassila Nogueira, Fonseca, Cleverson Alves, Ferreira, Junia Raquel Dutra, Adorno, Elisângela Vitoria, Lyra, Isa Menezes, Adekile, Adekunle D., Barbosa, Cynara Gomes, and Goncalves, Marilda Souza

Subjects
SICKLE cell anemia, ALANINE aminotransferase, ASPARTATE aminotransferase, LACTATE dehydrogenase, BASOPHILS, MONONUCLEAR leukocytes
Abstract

The present study aimed to investigate the association of Nε-carboxymethyllysine (CML) with laboratory parameters and βS haplotypes in pediatric sickle cell anemia (SCA) patients with or without hydroxyurea (HU) therapy. We included 55 children with SCA (SCAtotal), where 27 were on HU treatment (SCA-HU+) and 28 without HU treatment (SCA-HU-). Laboratory characteristics were determined using electronic methods while CML was measured using competitive ELISA. βS haplotypes were determined by RFLP-PCR. Significant increases in MCV and MCH and significant decreases in leukocytes, eosinophils, basophils, atypical lymphocytes, lymphocytes, and monocytes were found in SCA-HU+ compared to SCA-HU-. SCA-HU+ presented significant reduction in aspartate transaminase and lactate dehydrogenase and increase in creatinine levels compared to SCA-HU-. CML levels were significantly higher in both SCA-HU+ and SCA-HU- compared to the healthy control. In addition, a negative correlation was found between CML and alanine transaminase in SCA-HU+ and SCAtotal (p<0.01). A significant association was found between CML levels and βS haplotypes. The results suggest that CML has a role to play in SCA complications, independent of HU therapy. [ABSTRACT FROM AUTHOR]

Published
2019
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21. Tuberculosis

Author

Duarte, Tonya Azevedo, Dutra, Alberto Augusto Noronha, Nery, Joilda Silva, Ribeiro, Samantha Brum, Pitanga, Thassila Nogueira, Silva, José R. Lapa e, Arruda, Sérgio Marcos, and Boéchat, Neio

Subjects
Ectosomes, Human polymorphonuclear neutrophil, Tuberculosis, Cellular immune response, Mycobacterium tuberculosis
Abstract

Texto completo: acesso restrito. p. 218–225 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-12T14:17:56Z No. of bitstreams: 1 Tonya Azevedo Duarte.pdf: 1042368 bytes, checksum: 72a82354af873a14f7ec429585669248 (MD5) Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-08-12T19:56:24Z (GMT) No. of bitstreams: 1 Tonya Azevedo Duarte.pdf: 1042368 bytes, checksum: 72a82354af873a14f7ec429585669248 (MD5) Made available in DSpace on 2014-08-12T19:56:24Z (GMT). No. of bitstreams: 1 Tonya Azevedo Duarte.pdf: 1042368 bytes, checksum: 72a82354af873a14f7ec429585669248 (MD5) Previous issue date: 2012 Background The existence of ectosome-like microvesicles released by neutrophils was proposed a few decades ago. Other studies revealed that the innate immune response during mycobacterial infection is accompanied by an intense migration of neutrophils to the site of infection, which may be important during the acute phase of tuberculosis. We found that the ectosomes derived from infected neutrophils are biologically active and can influence the survival of Mycobacterium tuberculosis within macrophages. Methods Mycobacteria were cultured on supplemented Middlebrook-7H9 broth. All strains were grown to the exponential phase and quantitated by serial dilution. Human neutrophils and macrophages were infected with mycobacteria. Ectosomes from neutrophils were isolated post-infection and characterized by transmission electron microscopy and flow cytometry. To determine whether these microvesicles influenced mycobactericidal activity, mycobacteria-infected macrophages were treated with isolated ectosomes. Results Ectosomes were released from neutrophils infected with mycobacteria. These ectosomes were derived from neutrophil plasma membrane and a small proportion stained with PKH26. These microvesicles, when incubated with infected macrophages, influenced antimycobacterial activity. Conclusions This is the first study to demonstrate that ectosomes that are shed from infected neutrophils influence mycobactericidal activity in macrophages in vitro, suggesting that these microvesicles have biological significance. Nevertheless, major gaps in our knowledge of microvesicle biology remain.

Published
2012
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22. Correlations between Transcranial Doppler Velocities and Laboratory Markers of SCA Severity

Author

Adanho, Corynne Stephanie A., Santiago, Rayra Pereira, Vieira, Camilo, Guarda, Caroline Conceicao, Santana, Sanzio, Figueiredo, Camylla Vilas Boas, Fiuza, Luciana Magalhaes, Caetano, Karoline Brito Coelho, Pitanga, Thassila Nogueira, Yahouedehou, Setondji Cocou Modeste Alexandre, Aleluia, Milena, Ferreira, Junia Raquel Dutra, Maffili, Vitor Valerio, Zanette, Dalila Luciola, Lyra, Isa Menezes, and Goncalves, Marilda

Published
2017
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24. Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

Author

Pitanga, Thassila Nogueira, primary, de Aragão França, Luciana, additional, Rocha, Viviane Costa Junqueira, additional, Meirelles, Thayna, additional, Matos Borges, Valéria, additional, Gonçalves, Marilda Souza, additional, Pontes-de-Carvalho, Lain Carlos, additional, Noronha-Dutra, Alberto Augusto, additional, and dos-Santos, Washington Luis Conrado, additional

Published
2014
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27. Endothelial Protein C Receptor (EPCR), Oxide Nitric Synthase (NOS) and Tissue Factor (Factor III) Gene Expression: The Role Like Promising Biomarkers In Sickle Cell Anemia

Author

Cerqueira, Bruno A. V., primary, Boas, Wendell Vilas, additional, Fonseca, Teresa Cristina, additional, Souza, Regiana Q., additional, Aleluia, Milena Magalhães, additional, Cunha, Bruna A., additional, Pimenta, Felipe A., additional, Pitanga, Thassila Nogueira, additional, Reis, João Oliveira, additional, Santana, Sanzio Silva, additional, and Goncalves, Marilda Souza, additional

Published
2013
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29. Association of homocysteine and inflammatory-related molecules in sickle cell anemia.

Author

Vilas-Boas, Wendell, Veloso Cerqueira, Bruno Antonio, Figueiredo, Camylla V. B., Santiago, Rayra Pereira, da Guarda, Caroline C., Pitanga, Thassila Nogueira, Santana, Sanzio Silva, Dias Zanette, Angela Maria, and Goncalves, Marilda de Souza

Subjects
HOMOCYSTEINE, SICKLE cell anemia, CYTOKINES, CELL adhesion molecules, INTERLEUKIN-17, VASCULAR diseases
Abstract

Objective: Investigate the role of homocysteine (Hcy), Th17-related cytokines, and adhesion molecules in the inflammatory state seen in the sickle cell anemia (SCA). Methods: We studied the Hcy, interleukin (IL)-17, and transforming growth factor β (TGF-β) cytokine levels of 62 SCA patients, as well as the expression levels of inflammatory and endothelial activation markers. Results: We found significant associations between Hcy levels and increased expression of IL-17 and TGF-β among SCA patients, and a positive significant correlation between Hcy and soluble vascular cellular adhesion molecules (sVCAM). SCA individuals had raised IL-17 levels when compared with controls. Discussion: These results suggest a possible role of Hyc in the induction of TGF-β and IL-17. Other authors proposed that Hcy may contribute to the initiation and progression of vascular disease by monocyte activation, resulting in the secretion of cytokines that amplify the inflammatory response. The role of Hcy in cytokine production and oxidative stress in the endothelium may explain the increase of sVCAM expression and, the vascular activation currently described among the SCA individuals with the highest Hcy serum levels. The chronic inflammation was observed in hyperhomocysteinemic mice, with an increased expression of VCAM-1 and plasma levels of tumor necrosis factor-alpha, showing an association of this inflammatory molecule and vascular changes. Conclusion: Our findings suggest that the increased levels of IL-17,Hcy and sVCAM contributes contributes to the vascular inflammation and activation presented by SCA patients, which probably have an important role in vaso-occlusion. On the basis of the presented data, IL-17 and Hcy might be considered as important components in the pathogenesis of SCA. [ABSTRACT FROM AUTHOR]

Published
2016
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32. Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with β S Haplotype in Children with Sickle Cell Anemia.

Author

Ndidi US, Adanho CSA, Santiago RP, Yahouédéhou SCMA, Santana SS, Mafili VV, Pitanga TN, Fonseca CA, Ferreira JRD, Adorno EV, Lyra IM, Adekile AD, Barbosa CG, and Goncalves MS

Subjects
Antisickling Agents therapeutic use, Aspartate Aminotransferases metabolism, Child, Creatinine metabolism, Female, Genotype, Haplotypes, Humans, Hydroxyurea therapeutic use, Inflammation, L-Lactate Dehydrogenase metabolism, Leukocytes, Lysine metabolism, Male, Anemia, Sickle Cell drug therapy, Anemia, Sickle Cell genetics, Lysine analogs & derivatives, beta-Globins genetics
Abstract

The present study aimed to investigate the association of N ε -carboxymethyllysine (CML) with laboratory parameters and β S haplotypes in pediatric sickle cell anemia (SCA) patients with or without hydroxyurea (HU) therapy. We included 55 children with SCA (SCA total ), where 27 were on HU treatment (SCA-HU + ) and 28 without HU treatment (SCA-HU - ). Laboratory characteristics were determined using electronic methods while CML was measured using competitive ELISA. β S haplotypes were determined by RFLP-PCR. Significant increases in MCV and MCH and significant decreases in leukocytes, eosinophils, basophils, atypical lymphocytes, lymphocytes, and monocytes were found in SCA-HU + compared to SCA-HU - . SCA-HU + presented significant reduction in aspartate transaminase and lactate dehydrogenase and increase in creatinine levels compared to SCA-HU - . CML levels were significantly higher in both SCA-HU + and SCA-HU - compared to the healthy control. In addition, a negative correlation was found between CML and alanine transaminase in SCA-HU + and SCA total ( p < 0.01). A significant association was found between CML levels and β S haplotypes. The results suggest that CML has a role to play in SCA complications, independent of HU therapy., Competing Interests: The authors have no conflict of interest to declare., (Copyright © 2019 Uche Samuel Ndidi et al.)

Published
2019
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