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3 results on '"Pisapia T"'

1. Effectiveness and safety of the A-H1N1 vaccine in children: a hospital-based case-control study

Author

Menniti Ippolito F, Da Cas R, Sagliocca L, Traversa G, Ferrazin F, Santuccio C, Tartaglia L, Trotta F, Di Pietro P, Renna S, Rossi R, Domenichini B, Gamba S, Trovato F, Tovo P, Bianciotto M, Calitri C, Gabiano C, Raffaldi I, Urbino A, Da Dalt L, Bavero V, Giordano L, Baraldi M, Bertuola F, Lorenzon E, Parata F, Perilongo G, Vendramin S, Frassineti M, Calvani AM, Chiappini E, De Martino M, Fancelli C, Mannelli F, Mazzantini R, Sollai S, Venturini E, Pirozzi N, Rauchi U, Reale A, Mores N, Bersani G, De Nisco A, Chiaretti A, Riccardi R, Romagnoli C, Tipo V, Dinardo M, Pisapia T, RAFANIELLO, Concetta, Fucà F, Di Rosa E., CAPUANO, Annalisa, PARRETTA, Elisabetta, Menniti Ippolito, F, Da Cas, R, Sagliocca, L, Traversa, G, Ferrazin, F, Santuccio, C, Tartaglia, L, Trotta, F, Di Pietro, P, Renna, S, Rossi, R, Domenichini, B, Gamba, S, Trovato, F, Tovo, P, Bianciotto, M, Calitri, C, Gabiano, C, Raffaldi, I, Urbino, A, Da Dalt, L, Bavero, V, Giordano, L, Baraldi, M, Bertuola, F, Lorenzon, E, Parata, F, Perilongo, G, Vendramin, S, Frassineti, M, Calvani, Am, Chiappini, E, De Martino, M, Fancelli, C, Mannelli, F, Mazzantini, R, Sollai, S, Venturini, E, Pirozzi, N, Rauchi, U, Reale, A, Mores, N, Bersani, G, De Nisco, A, Chiaretti, A, Riccardi, R, Romagnoli, C, Tipo, V, Dinardo, M, Pisapia, T, Capuano, Annalisa, Parretta, Elisabetta, Rafaniello, Concetta, Fucà, F, and Di Rosa, E.

Published
2011

2. Increased D-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice

Author

Robert Nisticò, Carmen Mazzola, Francesco Errico, Dalila Astone, Nicola Biagio Mercuri, Antimo D'Aniello, Alessandro Usiello, Francesco Napolitano, Teresa Pisapia, Michela Giustizieri, Errico, Francesco, Robert, Nistic?, Napolitano, Francesco, Carmen, Mazzola, Dalila, Astone, Teresa, Pisapia, Michela, Giustizieri, Antimo, D?aniello, Nicola B., Mercuri, Alessandro, Usiello, Errico, F, Nisticò, R, Napolitano, F, Mazzola, C, Astone, D, Pisapia, T, Giustizieri, M, D'Aniello, A, Mercuri, Nb, and Usiello, Alessandro

Subjects
Agonist, Male, Aging, Maze Learning, Animals, Synapses, Hippocampus, Brain, D-Aspartic Acid, Exploratory Behavior, Mice, Excitatory Postsynaptic Potentials, Mice, Inbred C57BL, Up-Regulation, Neuronal Plasticity, medicine.drug_class, Nonsynaptic plasticity, Hippocampal formation, Biology, Inbred C57BL, NMDA receptors, Synaptic plasticity, pathology/physiology, Animals, Brain, metabolism/physiology, D-Aspartic Acid, metabolism/physiology, Excitatory Postsynaptic Potentials, physiology, Exploratory Behavior, physiology, Hippocampus, pathology/physiology, Male, Maze Learning, physiology, Mice, Mice, Inbred C57BL, Neuronal Plasticity, physiology, Synapses, parasitology/physiology, Up-Regulation, physiology, Metaplasticity, D-Aspartete, Brain aging, reference memory, medicine, d-Aspartate, General Neuroscience, Settore BIO/14, Long-term potentiation, NMDA receptor, nervous system, Neurology (clinical), Geriatrics and Gerontology, Neuroscience, Developmental Biology
Abstract

"Until recently, free d-amino acids were thought to be involved only in bacterial physiology. Nevertheless, today there is evidence that D-serine, by acting as co-agonist at NMDARs, plays a role in controlling neuronal functions in mammals. Besides D-serine, another D-amino acid, D-aspartate (D-Asp), is found in the mammalian brain with a temporal gradient of occurrence: high in embryo and low in adult. In this study, we demonstrate that D-Asp acts as an endogenous NMDAR agonist, since it triggers currents via interaction with each of NR2A-D receptor subunits. According to its pharmacological features, we showed that oral administration of D-Asp strongly enhances NMDAR-dependent LTP in adulthood and, in turn, completely rescues the synaptic plasticity decay observed in the hippocampus of aged animals. Therefore, our findings suggest a tantalizing hypothesis for which this in-embryo-occurring D-amino acid, when "forced" over its physiological content, may disclose plasticity windows inside which it counteracts the age-related reduction of NMDAR signaling."

Published
2009

3. Increased D-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice.

Author

Errico F, Nisticò R, Napolitano F, Mazzola C, Astone D, Pisapia T, Giustizieri M, D'Aniello A, Mercuri NB, and Usiello A

Subjects
Aging pathology, Animals, Brain metabolism, Brain physiology, D-Aspartic Acid metabolism, Excitatory Postsynaptic Potentials physiology, Exploratory Behavior physiology, Hippocampus pathology, Male, Maze Learning physiology, Mice, Mice, Inbred C57BL, Synapses parasitology, Aging physiology, D-Aspartic Acid physiology, Hippocampus physiology, Neuronal Plasticity physiology, Synapses physiology, Up-Regulation physiology
Abstract

Until recently, free d-amino acids were thought to be involved only in bacterial physiology. Nevertheless, today there is evidence that D-serine, by acting as co-agonist at NMDARs, plays a role in controlling neuronal functions in mammals. Besides D-serine, another D-amino acid, D-aspartate (D-Asp), is found in the mammalian brain with a temporal gradient of occurrence: high in embryo and low in adult. In this study, we demonstrate that D-Asp acts as an endogenous NMDAR agonist, since it triggers currents via interaction with each of NR2A-D receptor subunits. According to its pharmacological features, we showed that oral administration of D-Asp strongly enhances NMDAR-dependent LTP in adulthood and, in turn, completely rescues the synaptic plasticity decay observed in the hippocampus of aged animals. Therefore, our findings suggest a tantalizing hypothesis for which this in-embryo-occurring D-amino acid, when "forced" over its physiological content, may disclose plasticity windows inside which it counteracts the age-related reduction of NMDAR signaling., (Copyright © 2010 Elsevier Inc. All rights reserved.)

Published
2011
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