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3,513 results on '"Pisanu A"'

1. Absolute reference for microwave polarization experiments -- The COSMOCal project and its proof of concept

Author

Ritacco, A., Bizzarri, L., Savorgnano, S., Boulanger, F., Pérault, M., Treuttel, J., Morfin, P., Catalano, A., Darson, D., Ponthieu, N., Feret, A., Maffei, B., Chahadih, A., Pisano, G., Zannoni, M., Nati, F., Macías-Pérez, J. F., Monfardini, A., Calvo, M., Murgia, M., Ortu, P., Pisanu, T., Aumont, J., Errard, J., Leclercq, S., and Migliaccio, M.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The cosmic microwave background (CMB), a remnant of the Big Bang, provides unparalleled insights into the primordial universe, its energy content, and the origin of cosmic structures. The success of forthcoming terrestrial and space experiments hinges on meticulously calibrated data. Specifically, the ability to achieve an absolute calibration of the polarization angles with a precision of < 0.1 deg is crucial to identify the signatures of primordial gravitational waves and cosmic birefringence within the CMB polarization. We introduce the COSMOCal project, designed to deploy a polarized source in space for calibrating microwave frequency observations. The project aims to integrate microwave polarization observations from small and large telescopes, ground-based and in space, into a unified scale, enhancing the effectiveness of each observatory and allowing robust combination of data. To demonstrate the feasibility and confirm the observational approach of our project, we developed a prototype instrument that operates in the atmospheric window centered at 260 GHz, specifically tailored for use with the NIKA2 camera at the IRAM 30 m telescope. We present the instrument components and their laboratory characterization. The results of tests performed with the fully assembled prototype using a KIDs-based instrument, similar concept of NIKA2, are also reported. This study paves the way for an observing campaign using the IRAM 30m telescope and contributes to the development of a space-based instrument., Comment: 13 pages, 13 figures. Submitted to Astronomy and Astrophysics

Published
2024

2. Study of solar brightness profiles in the 18-26 GHz frequency range with INAF radio telescopes II. Evidence for coronal emission

Author

Marongiu, M., Pellizzoni, A., Righini, S., Mulas, S., Nesti, R., Burtovoi, A., Romoli, M., Serra, G., Valente, G., Egron, E., Murtas, G., Iacolina, M. N., Melis, A., Guglielmino, S. L., Loru, S., Zucca, P., Zanichelli, A., Bachetti, M., Bemporad, A., Buffa, F., Concu, R., Deiana, G. L., Karakotia, C., Ladu, A., Maccaferri, A., Marongiu, P., Messerotti, M., Navarrini, A., Orfei, A., Ortu, P., Pili, M., Pisanu, T., Pupillo, G., Romano, P., Saba, A., Schirru, L., Tiburzi, C., Abbo, L., Frassati, F., Giarrusso, M., Jerse, G., Landini, F., Pancrazzi, M., Russano, G., Sasso, C., and Susino, R.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

One of the most important objectives of solar physics is the physical understanding of the solar atmosphere, the structure of which is also described in terms of the density (N) and temperature (T) distributions of the atmospheric matter. Several multi-frequency analyses show that the characteristics of these distributions are still debated, especially for the outer coronal emission. We aim to constrain the T and N distributions of the solar atmosphere through observations in the centimetric radio domain. We employ single-dish observations from two of the INAF radio telescopes at the K-band frequencies (18 - 26 GHz). We investigate the origin of the significant brightness temperature ($T_B$) level that we detected up to the upper corona ($\sim 800$ Mm of altitude with respect to the photospheric solar surface). To probe the physical origin of the atmospheric emission and to constrain instrumental biases, we reproduced the solar signal by convolving specific 2D antenna beam models. The analysis of the solar atmosphere is performed by adopting a physical model that assumes the thermal bremsstrahlung as the emission mechanism, with specific T and N distributions. The modelled $T_B$ profiles are compared with those observed by averaging solar maps obtained during the minimum of solar activity (2018 - 2020). The T and N distributions are compatible (within $25\%$ of uncertainty) with the model up to $\sim 60$ Mm and $\sim 100$ Mm of altitude, respectively. The analysis of the role of the antenna beam pattern on our solar maps proves the physical nature of the atmospheric emission in our images up to the coronal tails seen in our $T_B$ profiles. The challenging analysis of the coronal radio emission at higher altitudes, together with the data from satellite instruments will require further multi-frequency measurements., Comment: 12 pages, 8 figures, 5 tables, accepted by A&A; v1

Published
2024

3. Study of solar brightness profiles in the 18-26 GHz frequency range with INAF radio telescopes I: solar radius

Author

Marongiu, M., Pellizzoni, A., Mulas, S., Righini, S., Nesti, R., Murtas, G., Egron, E., Iacolina, M. N., Melis, A., Valente, G., Serra, G., Guglielmino, S. L., Zanichelli, A., Romano, P., Loru, S., Bachetti, M., Bemporad, A., Buffa, F., Concu, R., Deiana, G. L., Karakotia, C., Ladu, A., Maccaferri, A., Marongiu, P., Messerotti, M., Navarrini, A., Orfei, A., Ortu, P., Pili, M., Pisanu, T., Pupillo, G., Saba, A., Schirru, L., Tiburzi, C., and Zucca, P.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The Sun is an extraordinary workbench, from which several fundamental astronomical parameters can be measured with high precision. Among these parameters, the solar radius $R_{\odot}$ plays an important role in several aspects, such as in evolutionary models. Despite the efforts in obtaining accurate measurements of $R_{\odot}$, the subject is still debated and measurements are puzzling and/or lacking in many frequency ranges. We aimed to determine the mean, equatorial, and polar radii of the Sun ($R_c$, $R_{eq}$, and $R_{pol}$) in the frequency range 18.1 - 26.1 GHz. We employed single-dish observations from the newly-appointed Medicina "Gavril Grueff" Radio Telescope and the Sardinia Radio Telescope (SRT) throughout 5 years, from 2018 to mid-2023, in the framework of the SunDish project for solar monitoring. Two methods to calculate the radius at radio frequencies are considered and compared. To assess the quality of our radius determinations, we also analysed the possible degrading effects of the antenna beam pattern on our solar maps, using two 2D-models. We carried out a correlation analysis with the evolution of the solar cycle through the calculation of Pearson's correlation coefficient $\rho$. We obtained several values for the solar radius - ranging between 959 and 994 arcsec - and $\rho$, with typical errors of a few arcsec. Our $R_{\odot}$ measurements, consistent with values reported in literature, suggest a weak prolatness of the solar limb ($R_{eq}$ > $R_{pol}$), although $R_{eq}$ and $R_{pol}$ are statistically compatible within 3$\sigma$ errors. The correlation analysis using the solar images from Grueff shows (1) a positive correlation between the solar activity and the temporal variation of $R_c$ (and $R_{eq}$) at all observing frequencies, and (2) a weak anti-correlation between the temporal variation of $R_{pol}$ and the solar activity at 25.8 GHz., Comment: 18 pages, 12 figures, 6 tables, accepted by A&A; v1

Published
2024

4. The MISTRAL Instrument and the Characterization of Its Detector Array

Author

Paiella, A., Cacciotti, F., Isopi, G., Barbavara, E., Battistelli, E. S., de Bernardis, P., Capalbo, V., Carbone, A., Carretti, E., Ciccalotti, E., Columbro, F., Coppolecchia, A., Cruciani, A., D’Alessandro, G., De Petris, M., Govoni, F., Lamagna, L., Levati, E., Marongiu, P., Mascia, A., Masi, S., Molinari, E., Murgia, M., Navarrini, A., Novelli, A., Occhiuzzi, A., Orlati, A., Pappalardo, E., Pettinari, G., Piacentini, F., Pisanu, T., Poppi, S., Porceddu, I., Ritacco, A., Schirru, M. R., and Vargiu, G.

Published
2024
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5. Observing galaxy clusters and the cosmic web through the Sunyaev Zel'dovich effect with MISTRAL

Author

Battistelli, E. S., Barbavara, E., de Bernardis, P., Cacciotti, F., Capalbo, V., Carbone, A., Carretti, E., Ciccalotti, D., Columbro, F., Coppolecchia, A., Cruciani, A., D'Alessandro, G., De Petris, M., Govoni, F., Isopi, G., Lamagna, L., Levati, E., Marongiu, P., Mascia, A., Masi, S., Molinari, E., Murgia, M., Navarrini, A., Novelli, A., Occhiuzzi, A., Orlati, A., Pappalardo, E., Paiella, A., Pettinari, G., Piacentini, F., Pisanu, T., Poppi, S., Porceddu, I., Ritacco, A., Schirru, M. R., and Vargiu, G. P.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Galaxy clusters and surrounding medium, can be studied using X-ray bremsstrahlung emission and Sunyaev Zel'dovich (SZ) effect. Both astrophysical probes, sample the same environment with different parameters dependance. The SZ effect is relatively more sensitive in low density environments and thus is useful to study the filamentary structures of the cosmic web. In addition, observations of the matter distribution require high angular resolution in order to be able to map the matter distribution within and around galaxy clusters. MISTRAL is a camera working at 90GHz which, once coupled to the Sardinia Radio Telescope, can reach $12''$ angular resolution over $4'$ field of view (f.o.v.). The forecasted sensitivity is $NEFD \simeq 10-15mJy \sqrt{s}$ and the mapping speed is $MS= 380'^{2}/mJy^{2}/h$. MISTRAL was recently installed at the focus of the SRT and soon will take its first photons., Comment: To appear in Proc. of the mm Universe 2023 conference, Grenoble (France), June 2023, published by F. Mayet et al. (Eds), EPJ Web of conferences, EDP Sciences

Published
2023

6. Towards a tailored approach for patients with acute diverticulitis and abscess formation. The DivAbsc2023 multicentre case–control study

Author

Podda, Mauro, Ceresoli, Marco, Di Martino, Marcello, Ortenzi, Monica, Pellino, Gianluca, Pata, Francesco, Ielpo, Benedetto, Murzi, Valentina, Balla, Andrea, Lepiane, Pasquale, Tamini, Nicolo’, De Carlo, Giulia, Davolio, Alessia, Di Saverio, Salomone, Cardinali, Luca, Botteri, Emanuele, Vettoretto, Nereo, Gelera, Pier Paolo, De Simone, Belinda, Grasso, Antonella, Clementi, Marco, Meloni, Danilo, Poillucci, Gaetano, Favi, Francesco, Rizzo, Roberta, Montori, Giulia, Procida, Giuseppa, Recchia, Irene, Agresta, Ferdinando, Virdis, Francesco, Cioffi, Stefano Piero Bernardo, Pellegrini, Martina, Sartelli, Massimo, Coccolini, Federico, Catena, Fausto, and Pisanu, Adolfo

Published
2024
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10. Effectiveness and safety of low molecular weight heparin in the management of acute pancreatitis: a systematic review and meta-analysis

Author

Mauro Podda, Valentina Murzi, Paola Marongiu, Marcello Di Martino, Belinda De Simone, Kumar Jayant, Monica Ortenzi, Federico Coccolini, Massimo Sartelli, Fausto Catena, Benedetto Ielpo, and Adolfo Pisanu

Subjects
Acute pancreatitis, Low molecular weight heparin, Pancreatitis treatment, Clinical outcomes in pancreatitis, Systematic review and meta-analysis, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Recent studies suggest that low-molecular-weight heparin (LMWH) may play a role in mitigating the severity of acute pancreatitis (AP). This systematic review and meta-analysis aims to synthesise existing evidence on the effectiveness and safety of LMWH in the treatment of moderately-severe and severe AP. Methods This systematic review and meta-analysis was conducted in accordance with the 2020 update of the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The systematic search was conducted in MEDLINE, the Cochrane Central Register of Controlled Trials, Scopus, and EMBASE, covering studies published up to February 2024. Randomised controlled trials (RCTs) and observational studies (n-RCTs) that reported the differences in the outcomes of AP for patients receiving LMWH in addition to the standard treatment (Intervention), compared to patients managed by standard treatment without LMWH (Control) were eligible. A random-effects model was used to calculate the pooled relative risk (RR) and mean differences (MD) with the corresponding 95% CI. Results Thirteen studies were included in the meta-analysis, all published between 2004 and 2022. Eight studies were RCTs, and five were n-RCTs. Data from 13,709 patients (6.971 Interventions and 6.738 Controls) were analysed. The comparison of Intervention and Control groups showed the superiority of LMWH to standard treatments in terms of overall mortality (RR = 0.44, 95% CI = 0.31; 0.64, P

Published
2024
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13. Exploring the genetics of lithium response in bipolar disorders

Author

Herrera-Rivero, Marisol, Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Amare, Azmeraw T., Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Bhattacharjee, Abesh Kumar, Biernacka, Joanna M., Birner, Armin, Cearns, Micah, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R., Colom, Francesc, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J. Raymond, Etain, Bruno, Falkai, Peter, Ferensztajn-Rochowiak, Ewa, Forstner, Andreas J., Frank, Josef, Frisén, Louise, Frye, Mark A., Fullerton, Janice M., Gallo, Carla, Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hasler, Roland, Hauser, Joanna, Heilbronner, Urs, Herms, Stefan, Hoffmann, Per, Hou, Liping, Hsu, Yi-Hsiang, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Kuo, Po-Hsiu, Kusumi, Ichiro, König, Barbara, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Maj, Mario, Manchia, Mirko, Marie-Claire, Cynthia, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan L., Millischer, Vincent, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Novák, Tomas, Nöthen, Markus M., O’Donovan, Claire, Ozaki, Norio, Papiol, Sergi, Pfennig, Andrea, Pisanu, Claudia, Potash, James B., Reif, Andreas, Reininghaus, Eva, Richard-Lepouriel, Hélène, Roberts, Gloria, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schubert, Klaus Oliver, Schulte, Eva C., Schweizer, Barbara W., Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Streit, Fabian, Tekola-Ayele, Fasil, Thalamuthu, Anbupalam, Tortorella, Alfonso, Turecki, Gustavo, Veeh, Julia, Vieta, Eduard, Viswanath, Biju, Witt, Stephanie H., Zandi, Peter P., Alda, Martin, Bauer, Michael, McMahon, Francis J., Mitchell, Philip B., Rietschel, Marcella, Schulze, Thomas G., and Baune, Bernhard T.

Published
2024
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14. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Perrone, Gennaro, Giuffrida, Mario, Abu-Zidan, Fikri, Kruger, Vitor F., Livrini, Marco, Petracca, Gabriele Luciano, Rossi, Giorgio, Tarasconi, Antonio, Tian, Brian W. C. A., Bonati, Elena, Mentz, Ricardo, Mazzini, Federico N., Campana, Juan P., Gasser, Elisabeth, Kafka-Ritsch, Reinhold, Felsenreich, Daniel M., Dawoud, Christopher, Riss, Stefan, Gomes, Carlos Augusto, Gomes, Felipe Couto, Gonzaga, Ricardo Alessandro Teixeira, Canton, Cassio Alfred Brattig, Pereira, Bruno Monteiro, Fraga, Gustavo P., Zem, Leticia Gonçalves, Cordeiro-Fonseca, Vinicius, de Mesquita Tauil, Renato, Atanasov, Boyko, Belev, Nikolay, Kovachev, Nikola, Meléndez, L. Juan José, Dimova, Ana, Dimov, Stefan, Zelić, Zdravko, Augustin, Goran, Bogdanić, Branko, Morić, Trpimir, Chouillard, Elie, Bajul, Melinda, De Simone, Belinda, Panis, Yves, Esposito, Francesco, Notarnicola, Margherita, Lauka, Lelde, Fabbri, Anna, Hentati, Hassen, Fnaiech, Iskander, Aurélien, Venara, Bougard, Marie, Roulet, Maxime, Demetrashvili, Zaza, Pipia, Irakli, Merabishvili, Giorgi, Bouliaris, Konstantinos, Koukoulis, Georgios, Doudakmanis, Christos, Xenaki, Sofia, Chrysos, Emmanuel, Kokkinakis, Stamatios, Vassiliu, Panteleimon, Michalopoulos, Nikolaos, Margaris, Ioannis, Kechagias, Aristotelis, Avgerinos, Konstantinos, Katunin, Jevgeni, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Mulita, Francesk, Maroulis, Ioannis, Vailas, Michail, Marinis, Athanasios, Siannis, Ioannis, Bourbouteli, Eirini, Manatakis, Dimitrios K., Tasis, Nikolaos, Acheimastos, Vasileios, Maria, Sotiropoulou, Stylianos, Kapiris, Kuzeridis, Harilaos, Korkolis, Dimitrios, Fradelos, Evangelos, Kavalieratos, George, Petropoulou, Thalia, Polydorou, Andreas, Papacostantinou, Ioannis, Triantafyllou, Tania, Kimpizi, Despina, Theodorou, Dimitrios, Toutouzas, Konstantinos, Chamzin, Alexandros, Frountzas, Maximos, Schizas, Dimitrios, Karavokyros, Ioannis, Syllaios, Athanasios, Charalabopoulos, Alexandros, Boura, Maria, Baili, Efstratia, Ioannidis, Orestis, Loutzidou, Lydia, Anestiadou, Elissavet, Tsouknidas, Ioannis, Petrakis, Georgios, Polenta, Eleni, Bains, Lovenish, Gupta, Rahul, Singh, Sudhir K., Khanduri, Archana, Bala, Miklosh, Kedar, Asaf, Pisano, Marcello, Podda, Mauro, Pisanu, Adolfo, Martines, Gennaro, Trigiante, Giuseppe, Lantone, Giuliano, Agrusa, Antonino, Di Buono, Giuseppe, Buscemi, Salvatore, Veroux, Massimiliano, Gioco, Rossella, Veroux, Gastone, Oragano, Luigi, Zonta, Sandro, Lovisetto, Federico, Feo, Carlo V., Pesce, Antonio, Fabbri, Nicolò, Lantone, Giulio, Marino, Fabio, Perrone, Fabrizio, Vincenti, Leonardo, Papagni, Vincenzo, Picciariello, Arcangelo, Rossi, Stefano, Picardi, Biagio, Del Monte, Simone Rossi, Visconti, Diego, Osella, Giulia, Petruzzelli, Luca, Pignata, Giusto, Andreuccetti, Jacopo, D’Alessio, Rossella, Buonfantino, Massimo, Guaitoli, Eleonora, Spinelli, Stefano, Sampietro, Gianluca Matteo, Corbellini, Carlo, Lorusso, Leonardo, Frontali, Alice, Pezzoli, Isabella, Bonomi, Alessandro, Chierici, Andrea, Cotsoglou, Christian, Manca, Giuseppe, Delvecchio, Antonella, Musa, Nicola, Casati, Massimiliano, Letizia, Laface, Abate, Emmanuele, Ercolani, Giorgio, D’Acapito, Fabrizio, Solaini, Leonardo, Guercioni, Gianluca, Cicconi, Simone, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Sena, Giuseppe, Castaldo, Pasquale, Cardamone, Eugenia, Portale, Giuseppe, Zuin, Matteo, Spolverato, Ylenia, Esposito, Marialusia, Isernia, Roberta Maria, Di Salvo, Maria, Manunza, Romina, Esposito, Giuseppe, Agus, Marcello, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele Tiziano, Tonucci, Tommaso Panici, Luppi, Davide, Casadei, Massimiliano, Bonilauri, Stefano, Pezzolla, Angela, Panebianco, Annunziata, Laforgia, Rita, De Luca, Maurizio, Zese, Monica, Parini, Dario, Jovine, Elio, De Sario, Giuseppina, Lombardi, Raffaele, Aprea, Giovanni, Palomba, Giuseppe, Capuano, Marianna, Argenio, Giulio, Orio, Gianluca, Armellino, Mariano Fortunato, Troian, Marina, Guerra, Martina, Nagliati, Carlo, Biloslavo, Alan, Germani, Paola, Aizza, Giada, Monsellato, Igor, Chahrour, Ali Chaouki, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Sganga, Gabriele, Fransvea, Pietro, Bianchi, Valentina, Boati, Paolo, Ferrara, Francesco, Palmieri, Francesco, Cianci, Pasquale, Gattulli, Domenico, Restini, Enrico, Cillara, Nicola, Cannavera, Alessandro, Nita, Gabriela Elisa, Sarnari, Jlenia, Roscio, Francesco, Clerici, Federico, Scandroglio, Ildo, Berti, Stefano, Cadeo, Alessandro, Filippelli, Alice, Conti, Luigi, Grassi, Carmine, Cattaneo, Gaetano Maria, Pighin, Marina, Papis, Davide, Gambino, Giovanni, Bertino, Vanessa, Schifano, Domenico, Prando, Daniela, Fogato, Luisella, Cavallo, Fabio, Ansaloni, Luca, Picheo, Roberto, Pontarolo, Nicholas, Depalma, Norma, Spampinato, Marcello, D’Ugo, Stefano, Lepre, Luca, Capponi, Michela Giulii, Campa, Rossella Domenica, Sarro, Giuliano, Dinuzzi, Vincenza Paola, Olmi, Stefano, Uccelli, Matteo, Ferrari, Davide, Inama, Marco, Moretto, Gianluigi, Fontana, Michele, Favi, Francesco, Picariello, Erika, Rampini, Alessia, Barberis, Andrea, Azzinnaro, Antonio, Oliva, Alba, Totaro, Luigi, Benzoni, Ilaria, Ranieri, Valerio, Capolupo, Gabriella Teresa, Carannante, Filippo, Caricato, Marco, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Pantalone, Desire, Alemanno, Giovanni, Scheiterle, Maximilian, Ceresoli, Marco, Cereda, Marco, Fumagalli, Chiara, Zanzi, Federico, Bolzon, Stefano, Guerra, Enrico, Lecchi, Francesca, Cellerino, Paola, Ardito, Antonella, Scaramuzzo, Rosa, Balla, Andrea, Lepiane, Pasquale, Tartaglia, Nicola, Ambrosi, Antonio, Pavone, Giovanna, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Ricci, Claudio, Torre, Beatrice, Russo, Iris Shari, Rottoli, Matteo, Tanzanu, Marta, Belvedere, Angela, Milone, Marco, Manigrasso, Michele, De Palma, Giovanni Domenico, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Magnone, Stefano, Bertoli, Paolo, Pisano, Michele, Massucco, Paolo, Palisi, Marco, Luzzi, Andrea-Pierre, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Kobe, Yoshiro, Toma, Takayuki, Shimamura, Fumihiko, Parker, Robert, Ranketi, Sinkeet, Mitei, Mercy, Svagzdys, Saulius, Pauzas, Henrikas, Zilinskas, Justas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Wong, Michael Pak-Kai, Jusoh, Asri Che, Zakaria, Muhammad Nazreen, Cruz, Daniel Rios, Elizalde, Aurea Barbara Rodriguez, Reynaud, Alejandro Bañon, Hernandez, Edgard Efren Lozada, Monroy, Jose maria Victor Palomo, Hinojosa-Ugarte, Diego, Quiodettis, Martha, Du Bois, María Esther, Latorraca, José, Major, Piotr, Pędziwiatr, Michał, Pisarska-Adamczyk, Magdalena, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, da Costa, Silvia Dantas, Pereira, Bela, Ferreira, Ana Rita Oliveira, Almeida, Filipe, Rocha, Ricardo, Carneiro, Carla, Perez, Diego Pita, Carvas, João, Rocha, Catarina, Ferreira, Cátia, Marques, Rita, Fernandes, Urânia, Leao, Pedro, Goulart, André, Pereira, Rita Gonçalves, Patrocínio, Sara Daniela Direito, de Mendonça, Nuno Gonçalo Gonçalves, Manso, Maria Isabel Cerqueira, Morais, Henrique Manuel Cardoso, Cardoso, Paulo Sebastião, Calu, Valentin, Miron, Adrian, Toma, Elena Adelina, Gachabayov, Mahir, Abdullaev, Abakar, Litvin, Andrey, Nechay, Taras, Tyagunov, Alexander, Yuldashev, Anvar, Bradley, Alison, Wilson, Michael, Panyko, Arpád, Látečková, Zuzana, Lacko, Vladimír, Lesko, Dusan, Soltes, Marek, Radonak, Jozef, Turrado-Rodriguez, Victor, Termes-Serra, Roser, Morales-Sevillano, Xavier, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Degiuli, Maurizio, Sofia, Silvia, Reddavid, Rossella, de Manzoni Garberini, Andrea, Buffone, Angelica, del Pozo, Eduardo Perea, Aparicio-Sánchez, Daniel, Dos Barbeito, Sandra, Estaire-Gómez, Mercedes, Vitón-Herrero, Rebeca, de los Ángeles Gil Olarte-Marquez, Mª, Gil-Martínez, José, Alconchel, Felipe, Nicolás-López, Tatiana, Rahy-Martin, Aida Cristina, Pelloni, María, Bañolas-Suarez, Raquel, Mendoza-Moreno, Fernando, Nisa, Francisca García-Moreno, Díez-Alonso, Manuel, Rodas, María Elisa Valle, Agundez, María Carmona, Andrés, María Inmaculada Pérez, Moreira, Claudia Cristina Lopes, Perez, Aintzane Lizarazu, Ponce, Iñigo Augusto, González-Castillo, Ana María, Membrilla-Fernández, Estela, Salvans, Silvia, Serradilla-Martín, Mario, Pardo, Pablo Sancho, Rivera-Alonso, Daniel, Dziakova, Jana, Huguet, Jose Mugüerza, Valle, Naila Pagès, Ruiz, Enrique Colás, Valcárcel, Cristina Rey, Moreno, Cristina Ruiz, Salazar, Yeniffer Tatiana Moreno, García, Juan Jesús Rubio, Micó, Silvia Sevila, López, Joaquín Ruiz, Farré, Silvia Pérez, Gomez, Maite Santamaria, Petit, Nuria Mestres, Titos-García, Alberto, Aranda-Narváez, Jose Manuel, Romacho-López, Laura, Sánchez-Guillén, Luis, Aranaz-Ostariz, Veronica, Bosch-Ramírez, Marina, Martínez-Pérez, Aleix, Martínez-López, Elías, Sebastián-Tomás, Juan Carlos, Jimenez-Riera, Granada, Jimenez-Vega, Javier, Cuellar, Jose Aurelio Navas, Campos-Serra, Andrea, Muñoz-Campaña, Anna, Gràcia-Roman, Raquel, Alegre, Javier Martínez, Pinto, Francisca Lima, O’Sullivan, Sara Nuñez, Antona, Francisco Blanco, Jiménez, Beatriz Muñoz, López-Sánchez, Jaime, Carmona, Zahira Gómez, Fernández, Rocio Torres, Sierra, Isabel Blesa, de León, Laura Román García, Moreno, Verónica Polaino, Iglesias, Eva, Cumplido, Paola Lora, Bravo, Altea Arango, Simó, Ignacio Rey, Domínguez, Carlota López, Caamaño, Aloia Guerreiro, Lozano, Rafael Calleja, Martínez, Manuel Durán, Torres, Álvaro Naranjo, de Quiros, Javier Tomas Morales Bernaldo, Pellino, Gianluca, Cloquell, Miriam Moratal, Moller, Elsa García, Jalal-Eldin, Sami, Abdoun, Ahmed K., Hamid, Hytham K. S., Lohsiriwat, Varut, Mongkhonsupphawan, Aitsariya, Baraket, Oussama, Ayed, Karim, Abbassi, Imed, Ali, Ali Ben, Ammar, Houssem, Kchaou, Ali, Tlili, Ahmed, Zribi, Imen, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Guner, Ali, Usta, Mehmet Arif, Reis, Murat Emre, Mantoglu, Baris, Gonullu, Emre, Akin, Emrah, Altintoprak, Fatih, Bayhan, Zulfu, Firat, Necattin, Isik, Arda, Memis, Ufuk, Bayrak, Mehmet, Altıntaş, Yasemin, Kara, Yasin, Bozkurt, Mehmet Abdussamet, Kocataş, Ali, Das, Koray, Seker, Ahmet, Ozer, Nazmi, Atici, Semra Demirli, Tuncer, Korhan, Kaya, Tayfun, Ozkan, Zeynep, Ilhan, Onur, Agackiran, Ibrahim, Uzunoglu, Mustafa Yener, Demirbas, Eren, Altinel, Yuksel, Meric, Serhat, Hacım, Nadir Adnan, Uymaz, Derya Salim, Omarov, Nail, Balık, Emre, Tebala, Giovanni D., Khalil, Hany, Rana, Mridul, Khan, Mansoor, Florence, Charlotte, Swaminathan, Christie, Leo, Cosimo Alex, Liasis, Lampros, Watfah, Josef, Trostchansky, Ivan, Delgado, Edward, Pontillo, Marcelo, Latifi, Rifat, Coimbra, Raul, Edwards, Sara, Lopez, Ana, Velmahos, George, Dorken, Ander, Gebran, Anthony, Palmer, Amanda, Oury, Jeffrey, Bardes, James M., Seng, Sirivan Suon, Coffua, Lauren S., Ratnasekera, Asanthi, Egodage, Tanya, Echeverria-Rosario, Karla, Armento, Isabella, Napolitano, Lena M., Sangji, Naveen F., Hemmila, Mark, Quick, Jacob A., Austin, Tyler R., Hyman, Theodore S., Curtiss, William, McClure, Amanda, Cairl, Nicholas, Biffl, Walter L., Truong, Hung P., Schaffer, Kathryn, Reames, Summer, Banchini, Filippo, Capelli, Patrizio, Coccolini, Federico, Sartelli, Massimo, Bravi, Francesca, Vallicelli, Carlo, Agnoletti, Vanni, Baiocchi, Gian Luca, and Catena, Fausto

Published
2024
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15. Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Author

Ou, Anna H., Rosenthal, Sara B., Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Alda, Martin, Amare, Azmeraw T., Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bauer, Michael, Baune, Bernhard T., Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Bhattacharjee, Abesh Kumar, Biernacka, Joanna M., Cervantes, Pablo, Chen, Guo-Bo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R., Colom, Francesc, Cousins, David A., Cruceanu, Cristiana, Czerski, Piotr M., Dantas, Clarissa R., Dayer, Alexandre, Del Zompo, Maria, Degenhardt, Franziska, DePaulo, J. Raymond, Étain, Bruno, Falkai, Peter, Fellendorf, Frederike Tabea, Ferensztajn-Rochowiak, Ewa, Forstner, Andreas J., Frisén, Louise, Frye, Mark A., Fullerton, Janice M., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Gruber, Oliver, Hashimoto, Ryota, Hauser, Joanna, Heilbronner, Urs, Herms, Stefan, Hoffmann, Per, Hofmann, Andrea, Hou, Liping, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kato, Tadafumi, Kittel-Schneider, Sarah, König, Barbara, Kuo, Po-Hsiu, Kusumi, Ichiro, Lackner, Nina, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Jaramillo, Carlos A. López, MacQueen, Glenda, Maj, Mario, Manchia, Mirko, Marie-Claire, Cynthia, Martinsson, Lina, Mattheisen, Manuel, McCarthy, Michael J., McElroy, Susan L., McMahon, Francis J., Mitchell, Philip B., Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, Ösby, Urban, Ozaki, Norio, Papiol, Sergi, Perlis, Roy H., Pisanu, Claudia, Potash, James B., Pfennig, Andrea, Reich-Erkelenz, Daniela, Reif, Andreas, Reininghaus, Eva Z., Rietschel, Marcella, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schubert, K. Oliver, Schulze, Thomas G., Schweizer, Barbara W., Seemüller, Florian, Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D., Shimoda, Kazutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Tighe, Sarah K., Tortorella, Alfonso, Turecki, Gustavo, Vieta, Eduard, Volkert, Julia, Witt, Stephanie, Wray, Naomi R., Wright, Adam, Young, L. Trevor, Zandi, Peter P., and Kelsoe, John R.

Published
2024
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17. Potential New Inflammatory Markers in Bronchiectasis: A Literature Review

Author

Francesco Rocco Bertuccio, Nicola Baio, Simone Montini, Valentina Ferroni, Vittorio Chino, Lucrezia Pisanu, Marianna Russo, Ilaria Giana, Alessandro Cascina, Valentina Conio, Amelia Grosso, Erica Gini, Federica Albicini, Angelo Guido Corsico, and Giulia Maria Stella

Subjects
bronchiectasis, inflammatory molecular drivers, TSLP, mucins, endotype, personalised medicine, Biology (General), QH301-705.5
Abstract

Specific molecular and inflammatory endotypes have been identified for chronic respiratory disorders, including asthma and COPD (chronic obstructive pulmonary disease). These endotypes correspond with clinical aspects of disease, enabling targeted medicines to address certain pathophysiologic pathways, often referred to as “precision medicine”. With respect to bronchiectasis, many comorbidities and underlying causes have been identified. Inflammatory endotypes have also been widely studied and reported. Additionally, several genes have been shown to affect disease progression. However, the lack of a clear classification has also hampered our understanding of the disease’s natural course. The aim of this review is, thus, to summarize the current knowledge on biomarkers and actionable targets of this complex pathologic condition and to point out unmet needs, which are required in the design of effective diagnostic and therapeutic trials.

Published
2024
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18. Lithium and its effects: does dose matter?

Author

Mirko Manchia, Pasquale Paribello, Martina Pinna, Luca Steardo, Bernardo Carpiniello, Federica Pinna, Claudia Pisanu, Alessio Squassina, and Tomas Hajek

Subjects
Micro-dose, Suicide, GSK-3Beta, BDNF, Drinking water, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Decades of clinical research have demonstrated the efficacy of lithium in treating acute episodes (both manic and depressive), as well as in preventing recurrences of bipolar disorder (BD). Specific to lithium is its antisuicidal effect, which appears to extend beyond its mood-stabilizing properties. Lithium’s clinical effectiveness is, to some extent, counterbalanced by its safety and tolerability profile. Indeed, monitoring of lithium levels is required by its narrow therapeutic index. There is consensus that adequate serum levels should be above 0.6 mEq/L to achieve clinical effectiveness. However, few data support the choice of this threshold, and increasing evidence suggests that lithium might have clinical and molecular effects at much lower concentrations. Content This narrative review is aimed at: (1) reviewing and critically interpreting the clinical evidence supporting the use of the 0.6 mEq/L threshold, (2) reporting a narrative synthesis of the evidence supporting the notion that lithium might be effective in much lower doses. Among these are epidemiological studies of lithium in water, evidence on the antisuicidal, anti-aggressive, and neuroprotective effects, including efficacy in preventing cognitive impairment progression, Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS), of lithium; and (3) revieweing biological data supporting clinically viable uses of lithium at low levels with the delineation of a mechanistic hypothesis surrounding its purported mechanism of action. The study selection was based on the authors’ preference, reflecting the varied and extensive expertise on the review subject, further enriched with an extensive pearl-growing strategy for relevant reviews and book sections. Conclusions Clinical and molecular effects of lithium are numerous, and its effects also appear to have a certain degree of specificity related to the dose administered. In sum, the clinical effects of lithium are maximal for mood stabilisation at concentrations higher than 0.6 mEq/l. However, lower levels may be sufficient for preventing depressive recurrences in older populations of patients, and microdoses could be effective in decreasing suicide risk, especially in patients with BD. Conversely, lithium’s ability to counteract cognitive decline appears to be exerted at subtherapeutic doses, possibly corresponding to its molecular neuroprotective effects. Indeed, lithium may reduce inflammation and induce neuroprotection even at doses several folds lower than those commonly used in clinical settings. Nevertheless, findings surrounding its purported mechanism of action are missing, and more research is needed to investigate the molecular targets of low-dose lithium adequately.

Published
2024
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19. Exploring the genetics of lithium response in bipolar disorders

Author

Marisol Herrera-Rivero, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Azmeraw T. Amare, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M. Biernacka, Armin Birner, Micah Cearns, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Francesc Colom, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Peter Falkai, Ewa Ferensztajn-Rochowiak, Andreas J. Forstner, Josef Frank, Louise Frisén, Mark A. Frye, Janice M. Fullerton, Carla Gallo, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Roland Hasler, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Po-Hsiu Kuo, Ichiro Kusumi, Barbara König, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Cynthia Marie-Claire, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Tomas Novák, Markus M. Nöthen, Claire O’Donovan, Norio Ozaki, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Hélène Richard-Lepouriel, Gloria Roberts, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Klaus Oliver Schubert, Eva C. Schulte, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fabian Streit, Fasil Tekola-Ayele, Anbupalam Thalamuthu, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Biju Viswanath, Stephanie H. Witt, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Marcella Rietschel, Thomas G. Schulze, and Bernhard T. Baune

Subjects
Bipolar disorder, Lithium treatment, Psychiatric symptoms, Comorbidity, Genetics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N = 2064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II. Results We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism. Conclusions Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II.

Published
2024
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20. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F. Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W. C. A. Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan P. Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M. Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P. Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L. Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konstantinos Bouliaris, Georgios Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Panteleimon Vassiliu, Nikolaos Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitrios Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir K. Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V. Feo, Antonio Pesce, Nicolò Fabbri, Giulio Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D’Alessio, Massimo Buonfantino, Eleonora Guaitoli, Stefano Spinelli, Gianluca Matteo Sampietro, Carlo Corbellini, Leonardo Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andrea Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D’Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Spolverato, Marialusia Esposito, Roberta Maria Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Luigi Giuseppe Asti, Daniele Tiziano Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, Gaetano Maria Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, Vanessa Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D’Ugo, Luca Lepre, Michela Giulii Capponi, Rossella Domenica Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, Desire Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, Paola Cellerino, Antonella Ardito, Rosa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci, Beatrice Torre, Iris Shari Russo, Matteo Rottoli, Marta Tanzanu, Angela Belvedere, Marco Milone, Michele Manigrasso, Giovanni Domenico De Palma, Micaela Piccoli, Gianmaria Casoni Pattacini, Stefano Magnone, Paolo Bertoli, Michele Pisano, Paolo Massucco, Marco Palisi, Andrea-Pierre Luzzi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Yoshiro Kobe, Takayuki Toma, Fumihiko Shimamura, Robert Parker, Sinkeet Ranketi, Mercy Mitei, Saulius Svagzdys, Henrikas Pauzas, Justas Zilinskas, Tomas Poskus, Marius Kryzauskas, Matas Jakubauskas, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Michael Pak-Kai Wong, Asri Che Jusoh, Muhammad Nazreen Zakaria, Daniel Rios Cruz, Aurea Barbara Rodriguez Elizalde, Alejandro Bañon Reynaud, Edgard Efren Lozada Hernandez, Jose maria Victor Palomo Monroy, Diego Hinojosa-Ugarte, Martha Quiodettis, María Esther Du Bois, José Latorraca, Piotr Major, Michał Pędziwiatr, Magdalena Pisarska-Adamczyk, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Silvia Dantas da Costa, Bela Pereira, Ana Rita Oliveira Ferreira, Filipe Almeida, Ricardo Rocha, Carla Carneiro, Diego Pita Perez, João Carvas, Catarina Rocha, Cátia Ferreira, Rita Marques, Urânia Fernandes, Pedro Leao, André Goulart, Rita Gonçalves Pereira, Sara Daniela Direito Patrocínio, Nuno Gonçalo Gonçalves de Mendonça, Maria Isabel Cerqueira Manso, Henrique Manuel Cardoso Morais, Paulo Sebastião Cardoso, Valentin Calu, Adrian Miron, Elena Adelina Toma, Mahir Gachabayov, Abakar Abdullaev, Andrey Litvin, Taras Nechay, Alexander Tyagunov, Anvar Yuldashev, Alison Bradley, Michael Wilson, Arpád Panyko, Zuzana Látečková, Vladimír Lacko, Dusan Lesko, Marek Soltes, Jozef Radonak, Victor Turrado-Rodriguez, Roser Termes-Serra, Xavier Morales-Sevillano, Pierfrancesco Lapolla, Andrea Mingoli, Gioia Brachini, Maurizio Degiuli, Silvia Sofia, Rossella Reddavid, Andrea de Manzoni Garberini, Angelica Buffone, Eduardo Perea del Pozo, Daniel Aparicio-Sánchez, Sandra Dos Barbeito, Mercedes Estaire-Gómez, Rebeca Vitón-Herrero, Mª de los Ángeles Gil Olarte-Marquez, José Gil-Martínez, Felipe Alconchel, Tatiana Nicolás-López, Aida Cristina Rahy-Martin, María Pelloni, Raquel Bañolas-Suarez, Fernando Mendoza-Moreno, Francisca García-Moreno Nisa, Manuel Díez-Alonso, María Elisa Valle Rodas, María Carmona Agundez, María Inmaculada Pérez Andrés, Claudia Cristina Lopes Moreira, Aintzane Lizarazu Perez, Iñigo Augusto Ponce, Ana María González-Castillo, Estela Membrilla-Fernández, Silvia Salvans, Mario Serradilla-Martín, Pablo Sancho Pardo, Daniel Rivera-Alonso, Jana Dziakova, Jose Mugüerza Huguet, Naila Pagès Valle, Enrique Colás Ruiz, Cristina Rey Valcárcel, Cristina Ruiz Moreno, Yeniffer Tatiana Moreno Salazar, Juan Jesús Rubio García, Silvia Sevila Micó, Joaquín Ruiz López, Silvia Pérez Farré, Maite Santamaria Gomez, Nuria Mestres Petit, Alberto Titos-García, Jose Manuel Aranda-Narváez, Laura Romacho-López, Luis Sánchez-Guillén, Veronica Aranaz-Ostariz, Marina Bosch-Ramírez, Aleix Martínez-Pérez, Elías Martínez-López, Juan Carlos Sebastián-Tomás, Granada Jimenez-Riera, Javier Jimenez-Vega, Jose Aurelio Navas Cuellar, Andrea Campos-Serra, Anna Muñoz-Campaña, Raquel Gràcia-Roman, Javier Martínez Alegre, Francisca Lima Pinto, Sara Nuñez O’Sullivan, Francisco Blanco Antona, Beatriz Muñoz Jiménez, Jaime López-Sánchez, Zahira Gómez Carmona, Rocio Torres Fernández, Isabel Blesa Sierra, Laura Román García de León, Verónica Polaino Moreno, Eva Iglesias, Paola Lora Cumplido, Altea Arango Bravo, Ignacio Rey Simó, Carlota López Domínguez, Aloia Guerreiro Caamaño, Rafael Calleja Lozano, Manuel Durán Martínez, Álvaro Naranjo Torres, Javier Tomas Morales Bernaldo de Quiros, Gianluca Pellino, Miriam Moratal Cloquell, Elsa García Moller, Sami Jalal-Eldin, Ahmed K. Abdoun, Hytham K. S. Hamid, Varut Lohsiriwat, Aitsariya Mongkhonsupphawan, Oussama Baraket, Karim Ayed, Imed Abbassi, Ali Ben Ali, Houssem Ammar, Ali Kchaou, Ahmed Tlili, Imen Zribi, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Ali Guner, Mehmet Arif Usta, Murat Emre Reis, Baris Mantoglu, Emre Gonullu, Emrah Akin, Fatih Altintoprak, Zulfu Bayhan, Necattin Firat, Arda Isik, Ufuk Memis, Mehmet Bayrak, Yasemin Altıntaş, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Koray Das, Ahmet Seker, Nazmi Ozer, Semra Demirli Atici, Korhan Tuncer, Tayfun Kaya, Zeynep Ozkan, Onur Ilhan, Ibrahim Agackiran, Mustafa Yener Uzunoglu, Eren Demirbas, Yuksel Altinel, Serhat Meric, Nadir Adnan Hacım, Derya Salim Uymaz, Nail Omarov, Emre Balık, Giovanni D. Tebala, Hany Khalil, Mridul Rana, Mansoor Khan, Charlotte Florence, Christie Swaminathan, Cosimo Alex Leo, Lampros Liasis, Josef Watfah, Ivan Trostchansky, Edward Delgado, Marcelo Pontillo, Rifat Latifi, Raul Coimbra, Sara Edwards, Ana Lopez, George Velmahos, Ander Dorken, Anthony Gebran, Amanda Palmer, Jeffrey Oury, James M. Bardes, Sirivan Suon Seng, Lauren S. Coffua, Asanthi Ratnasekera, Tanya Egodage, Karla Echeverria-Rosario, Isabella Armento, Lena M. Napolitano, Naveen F. Sangji, Mark Hemmila, Jacob A. Quick, Tyler R. Austin, Theodore S. Hyman, William Curtiss, Amanda McClure, Nicholas Cairl, Walter L. Biffl, Hung P. Truong, Kathryn Schaffer, Summer Reames, Filippo Banchini, Patrizio Capelli, Federico Coccolini, Massimo Sartelli, Francesca Bravi, Carlo Vallicelli, Vanni Agnoletti, Gian Luca Baiocchi, and Fausto Catena

Subjects
Hartmann’s procedure, Ostomy, Emergency surgery, Resection, Primary anastomosis, Left side, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P

Published
2024
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21. The importance of cognitive intervention in acquired traumatic brain injury during 6 months of multidisciplinary rehabilitation: a case description

Author

Patrizia Pisanu, Nicolò Contu, Cristiana Picciau, Stefano Milighetti, Emiliano Deiana, Valeria Vannucci, Benedetta Centonze, Sara Pirastru, Sinai Del Carmen Fabriani Sanchez, and Dario Lucchetti

Subjects
Neurocognitive disorder, LCF, traumatic brain injury, neurorehabilitation, cognitive rehabilitation, Medicine
Abstract

Planning an immediate and multidisciplinary rehabilitation is crucial to reduce the significant physical, cognitive, and psychosocial impact resulting from head trauma. This study highlights the importance of ongoing cognitive rehabilitation in conjunction with other rehabilitation therapies, such as motor, occupational, and speech therapy, for a 19-year-old woman who suffered an acquired traumatic brain injury in a high-energy vehicle accident. When the patient was admitted to the hospital, their cognitive functioning (LCF) was 4 (confused-agitated state), their Barthel index was 0, their Glasgow coma scale (GCS) was 7, and their disability rating scale (DRS) was 7. The patient’s cognitive functioning improved to LCF 8 (purposeful-appropriate), numerical rating scale: 0/10, Barthel index: 53, GCS:15, and DRS: 5 at the time of discharge from the neurorehabilitation unit. In conclusion, early cognitive intervention in a multidisciplinary rehabilitation program is essential to maximizing the patient’s potential and improving the rehabilitation’s outcome.

Published
2024
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23. Lipid rafts mediate multilineage differentiation of human dental pulp-derived stem cells (DPSCs)

Author

Santilli, Francesca, Fabrizi, Jessica, Martellucci, Stefano, Santacroce, Costantino, Iorio, Egidio, Pisanu, Maria Elena, Chirico, Mattea, Lancia, Loreto, Pulcini, Fanny, Manganelli, Valeria, Sorice, Maurizio, Delle Monache, Simona, and Mattei, Vincenzo

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Stem Cell Research, Prevention, Dental/Oral and Craniofacial Disease, Underpinning research, 1.1 Normal biological development and functioning, DPSCs, lipid rafts, gangliosides, osteogenic, chondrogenic and adipogenic differentiation, multilineage differentiation, mesenchymal stem cells, dental pulp stem cells, Biological sciences, Biomedical and clinical sciences
Abstract

Cell outer membranes contain glycosphingolipids and protein receptors, which are integrated into glycoprotein domains, known as lipid rafts, which are involved in a variety of cellular processes, including receptor-mediated signal transduction and cellular differentiation process. In this study, we analyzed the lipidic composition of human Dental Pulp-Derived Stem Cells (DPSCs), and the role of lipid rafts during the multilineage differentiation process. The relative quantification of lipid metabolites in the organic fraction of DPSCs, performed by Nuclear Magnetic Resonance (NMR) spectroscopy, showed that mono-unsaturated fatty acids (MUFAs) were the most representative species in the total pool of acyl chains, compared to polyunsatured fatty acids (PUFAs). In addition, the stimulation of DPSCs with different culture media induces a multilineage differentiation process, determining changes in the gangliosides pattern. To understand the functional role of lipid rafts during multilineage differentiation, DPSCs were pretreated with a typical lipid raft affecting agent (MβCD). Subsequently, DPSCs were inducted to differentiate into osteoblast, chondroblast and adipoblast cells with specific media. We observed that raft-affecting agent MβCD prevented AKT activation and the expression of lineage-specific mRNA such as OSX, PPARγ2, and SOX9 during multilineage differentiation. Moreover, this compound significantly prevented the tri-lineage differentiation induced by specific stimuli, indicating that lipid raft integrity is essential for DPSCs differentiation. These results suggest that lipid rafts alteration may affect the signaling pathway activated, preventing multilineage differentiation.

Published
2023

24. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Author

Amare, Azmeraw T., Thalamuthu, Anbupalam, Schubert, Klaus Oliver, Fullerton, Janice M., Ahmed, Muktar, Hartmann, Simon, Papiol, Sergi, Heilbronner, Urs, Degenhardt, Franziska, Tekola-Ayele, Fasil, Hou, Liping, Hsu, Yi-Hsiang, Shekhtman, Tatyana, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Hasler, Roland, Richard-Lepouriel, Hélène, Perroud, Nader, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M., Birner, Armin, Marie-Claire, Cynthia, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Del Zompo, Maria, DePaulo, J. Raymond, Étain, Bruno, Jamain, Stephane, Falkai, Peter, Forstner, Andreas J., Frisen, Louise, Frye, Mark A., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Fallgatter, Andreas J., Stegmaier, Sophia, Ethofer, Thomas, Biere, Silvia, Petrova, Kristiyana, Schuster, Ceylan, Adorjan, Kristina, Budde, Monika, Heilbronner, Maria, Kalman, Janos L., Kohshour, Mojtaba Oraki, Reich-Erkelenz, Daniela, Schaupp, Sabrina K., Schulte, Eva C., Senner, Fanny, Vogl, Thomas, Anghelescu, Ion-George, Arolt, Volker, Dannlowski, Udo, Dietrich, Detlef, Figge, Christian, Jäger, Markus, Lang, Fabian U., Juckel, Georg, Konrad, Carsten, Reimer, Jens, Schmauß, Max, Schmitt, Andrea, Spitzer, Carsten, von Hagen, Martin, Wiltfang, Jens, Zimmermann, Jörg, Andlauer, Till F. M., Fischer, Andre, Bermpohl, Felix, Ritter, Philipp, Matura, Silke, Gryaznova, Anna, Falkenberg, Irina, Yildiz, Cüneyt, Kircher, Tilo, Schmidt, Julia, Koch, Marius, Gade, Kathrin, Trost, Sarah, Haussleiter, Ida S., Lambert, Martin, Rohenkohl, Anja C., Kraft, Vivien, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Ferensztajn-Rochowiak, Ewa, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Tortorella, Alfonso, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan, Colom, Francesc, Millischer, Vincent, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, O’Donovan, Claire, Ozaki, Norio, Pfennig, Andrea, Pisanu, Claudia, Potash, James B., Reif, Andreas, Reininghaus, Eva, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schweizer, Barbara W., Severino, Giovanni, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Maj, Mario, Turecki, Gustavo, Vieta, Eduard, Veeh, Julia, Witt, Stephanie H., Wright, Adam, Zandi, Peter P., Mitchell, Philip B., Bauer, Michael, Alda, Martin, Rietschel, Marcella, McMahon, Francis J., Schulze, Thomas G., Clark, Scott R., and Baune, Bernhard T.

Published
2023
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26. Insights into attention and memory difficulties in post-COVID syndrome using standardized neuropsychological tests and experimental cognitive tasks

Author

Sandra Arbula, Elisabetta Pisanu, Giulia Bellavita, Alina Menichelli, Alberta Lunardelli, Giovanni Furlanis, Paolo Manganotti, Stefano Cappa, and Raffaella Rumiati

Subjects
Medicine, Science
Abstract

Abstract The COVID-19 pandemic has given rise to post-acute cognitive symptoms, often described as ‘brain fog’. To comprehensively grasp the extent of these issues, we conducted a study integrating traditional neuropsychological assessments with experimental cognitive tasks targeting attention control, working memory, and long-term memory, three cognitive domains most commonly associated with ‘brain fog’. We enrolled 33 post-COVID patients, all self-reporting cognitive difficulties, and a matched control group (N = 27) for cognitive and psychological assessments. Our findings revealed significant attention deficits in post-COVID patients across both neuropsychological measurements and experimental cognitive tasks, evidencing reduced performance in tasks involving interference resolution and selective and sustained attention. Mild executive function and naming impairments also emerged from the neuropsychological assessment. Notably, 61% of patients reported significant prospective memory failures in daily life, aligning with our recruitment focus. Furthermore, our patient group showed significant alterations in the psycho-affective domain, indicating a complex interplay between cognitive and psychological factors, which could point to a non-cognitive determinant of subjectively experienced cognitive changes following COVID-19. In summary, our study offers valuable insights into attention challenges faced by individuals recovering from COVID-19, stressing the importance of comprehensive cognitive and psycho-affective evaluations for supporting post-COVID individuals.

Published
2024
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27. Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Author

Anna H. Ou, Sara B. Rosenthal, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Martin Alda, Azmeraw T. Amare, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Michael Bauer, Bernhard T. Baune, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M. Biernacka, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Francesc Colom, David A. Cousins, Cristiana Cruceanu, Piotr M. Czerski, Clarissa R. Dantas, Alexandre Dayer, Maria Del Zompo, Franziska Degenhardt, J. Raymond DePaulo, Bruno Étain, Peter Falkai, Frederike Tabea Fellendorf, Ewa Ferensztajn-Rochowiak, Andreas J. Forstner, Louise Frisén, Mark A. Frye, Janice M. Fullerton, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Tadafumi Kato, Sarah Kittel-Schneider, Barbara König, Po-Hsiu Kuo, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Carlos A. López Jaramillo, Glenda MacQueen, Mario Maj, Mirko Manchia, Cynthia Marie-Claire, Lina Martinsson, Manuel Mattheisen, Michael J. McCarthy, Susan L. McElroy, Francis J. McMahon, Philip B. Mitchell, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Novák, Urban Ösby, Norio Ozaki, Sergi Papiol, Roy H. Perlis, Claudia Pisanu, James B. Potash, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Eva Z. Reininghaus, Marcella Rietschel, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, K. Oliver Schubert, Thomas G. Schulze, Barbara W. Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Sarah K. Tighe, Alfonso Tortorella, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie Witt, Naomi R. Wray, Adam Wright, L. Trevor Young, Peter P. Zandi, and John R. Kelsoe

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

Published
2024
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28. Solar observations with single-dish INAF radio telescopes: continuum imaging in the 18-26 GHz range

Author

Pellizzoni, A., Righini, S., Iacolina, M. N., Marongiu, M., Mulas, S., Murtas, G., Valente, G., Egron, E., Bachetti, M., Buffa, F., Concu, R., Deiana, G. L., Guglielmino, S. L., Ladu, A., Loru, S., Maccaferri, A., Marongiu, P., Melis, A., Navarrini, A., Orfei, A., Ortu, P., Pili, M., Pisanu, T., Pupillo, G., Saba, A., Schirru, L., Serra, G., Tiburzi, C., Zanichelli, A., Zucca, P., and Messerotti, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We present a new solar radio imaging system implemented through the upgrade of the large single-dish telescopes of the Italian National Institute for Astrophysics (INAF), not originally conceived for solar observations. During the development and early science phase of the project (2018-2020), we obtained about 170 maps of the entire solar disk in the 18-26 GHz band, filling the observational gap in the field of solar imaging at these frequencies. These solar images have typical resolutions in the 0.7-2 arcmin range and a brightness temperature sensitivity <10 K. Accurate calibration adopting the Supernova Remnant Cas A as a flux reference, provided typical errors <3% for the estimation of the quiet-Sun level components and for active regions flux measurements. As a first early science result of the project, we present a catalog of radio continuum solar imaging observations with Medicina 32-m and SRT 64-m radio telescopes including the multi-wavelength identification of active regions, their brightness and spectral characterization. The interpretation of the observed emission as thermal bremsstrahlung components combined with gyro-magnetic variable emission pave the way to the use of our system for long-term monitoring of the Sun. We also discuss useful outcomes both for solar physics (e.g. study of the chromospheric network dynamics) and space weather applications (e.g. flare precursors studies)., Comment: 43 pages, 11 figures, 6 tables, accepted for publication in Solar Physics

Published
2022
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29. High angular resolution Sunyaev Zel'dovich observations: the case of MISTRAL

Author

Battistelli, E. S., Barbavara, E., de Bernardis, P., Cacciotti, F., Capalbo, V., Carretti, E., Columbro, F., Coppolecchia, A., Cruciani, A., D'Alessandro, G., De Petris, M., Govoni, F., Isopi, G., Lamagna, L., Marongiu, P., Masi, S., Mele, L., Molinari, E., Murgia, M., Navarrini, A., Orlati, A., Paiella, A., Pettinari, G., Piacentini, F., Pisanu, T., Poppi, S., Presta, G., and Radiconi, F.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The MIllimeter Sardinia radio Telescope Receiver based on Array of Lumped elements kids, MISTRAL, is a millimetric ($\simeq 90GHz$) multipixel camera being built for the Sardinia Radio Telescope. It is going to be a facility instrument and will sample the sky with 12 arcsec angular resolution, 4 arcmin field of view, through 408 Kinetic Inductance Detectors (KIDs). The construction and the beginning of commissioning is planned to be in 2022. MISTRAL will allow the scientific community to propose a wide variety of scientific cases including protoplanetary discs study, star forming regions, galaxies radial profiles, and high angular resolution measurements of the Sunyaev Zel'dovich (SZ) effect with the investigation of the morphology of galaxy cluster and the search for the Cosmic Web., Comment: 18 pages, 6 figure, accepted for pubblication in the International Journal of Modern Physics D

Published
2022

30. Contributions of birds to the feeding of ticks at host community level: Effects of tick burden, host density and yearly fluctuations

Author

Amalia Rataud, Alex Drouin, Laure Bournez, Benoit Pisanu, Sara Moutailler, Pierre-Yves Henry, and Maud Marsot

Subjects
Bird community, Tick feeding, Ixodes ricinus, Infectious and parasitic diseases, RC109-216
Abstract

The eco-epidemiology of tick-borne diseases hinges on the abundance and distribution of hosts that sustain tick populations and the pathogens they carry. Research into the role of bird species in the feeding of Ixodes ricinus ticks, the primary tick species of veterinary and public health importance in Europe, remains scarce. This study endeavors to bridge these knowledge gaps by (i) assessing the density of feeding ticks (DFT) within a bird community to pinpoint species making substantial contributions, and (ii) exploring interannual variations in DFT over an extended timeline. Furthermore, we investigate whether variations in individual tick burden (TB) were more closely associated with the characteristics of bird species or interannual variations affecting the density of questing tick, using interannual TB variation as a surrogate. To fulfill these aims, we conducted a 13-year longitudinal study monitoring I. ricinus ticks feeding on a bird community in a periurban forest in France, covering breeding periods from 2007 to 2019. Within this community, we identified seven principal bird species significantly contributing to I. ricinus tick feeding: the Common Blackbird (Turdus merula), the Song Thrush (Turdus philomelos), the European Robin (Erithacus rubecula), the Dunnock (Prunella modularis), the Eurasian Blackcap (Sylvia atricapilla), the Great Tit (Parus major), and the Common Nightingale (Luscinia megarhynchos). Our results show that the bird community's contribution to tick feeding remained relatively consistent from year-to-year, though certain years displayed higher or lower DFT values related to the average over the study period. Moreover, five out the seven major species accounted for 80 % to 95 % of DFT annually. Consequently, we emphasized the need to broaden the scope of future research on bird contributions to tick population dynamics beyond merely thrushes (Turdidae species), to encompass a more diverse range of species, particularly those common birds that engage in ground foraging activities. Furthermore, variations in individual tick burden were predominantly influenced by the characteristics of bird species rather than by interannual variability in infestation rates. This finding suggests a significant role for species-specific traits in determining tick exposure and susceptibility. In conclusion, our study offers new insights into the medium-term dynamics of tick-bird ecological systems, underscoring the need for future study of tick populations and their interactions with vertebrate hosts to improve our understanding of tick-borne disease circulation.

Published
2024
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31. Follow-up strategies for patients with splenic trauma managed non-operatively: the 2022 World Society of Emergency Surgery consensus document.

Author

Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Virdis, Francesco, Favi, Francesco, Wiik Larsen, Johannes, Coccolini, Federico, Sartelli, Massimo, Pararas, Nikolaos, Beka, Solomon, Bonavina, Luigi, Bova, Raffaele, Pisanu, Adolfo, Abu-Zidan, Fikri, Balogh, Zsolt, Chiara, Osvaldo, Wani, Imtiaz, Stahel, Philip, Di Saverio, Salomone, Scalea, Thomas, Soreide, Kjetil, Sakakushev, Boris, Amico, Francesco, Martino, Costanza, Hecker, Andreas, deAngelis, Nicola, Chirica, Mircea, Kirkpatrick, Andrew, Pikoulis, Emmanouil, Kluger, Yoram, Bensard, Denis, Ansaloni, Luca, Fraga, Gustavo, Civil, Ian, Tebala, Giovanni, Di Carlo, Isidoro, Cui, Yunfeng, Coimbra, Raul, Agnoletti, Vanni, Sall, Ibrahima, Tan, Edward, Picetti, Edoardo, Litvin, Andrey, Damaskos, Dimitrios, Inaba, Kenji, Leung, Jeffrey, Maier, Ronald, Biffl, Walt, Leppaniemi, Ari, Moore, Ernest, Gurusamy, Kurinchi, Catena, Fausto, and Galante, Joseph

Subjects
Consensus, Conservative treatment, Diagnostic imaging, Embolization, Follow-up, Nonoperative management, Spleen, Trauma, Abdominal Injuries, Adult, Child, Consensus, Follow-Up Studies, Hemoglobins, Heparin, Low-Molecular-Weight, Humans, Prospective Studies, Wounds, Nonpenetrating
Abstract

BACKGROUND: In 2017, the World Society of Emergency Surgery published its guidelines for the management of adult and pediatric patients with splenic trauma. Several issues regarding the follow-up of patients with splenic injuries treated with NOM remained unsolved. METHODS: Using a modified Delphi method, we sought to explore ongoing areas of controversy in the NOM of splenic trauma and reach a consensus among a group of 48 international experts from five continents (Africa, Europe, Asia, Oceania, America) concerning optimal follow-up strategies in patients with splenic injuries treated with NOM. RESULTS: Consensus was reached on eleven clinical research questions and 28 recommendations with an agreement rate ≥ 80%. Mobilization after 24 h in low-grade splenic trauma patients (WSES Class I, AAST Grades I-II) was suggested, while in patients with high-grade splenic injuries (WSES Classes II-III, AAST Grades III-V), if no other contraindications to early mobilization exist, safe mobilization of the patient when three successive hemoglobins 8 h apart after the first are within 10% of each other was considered safe according to the panel. The panel suggests adult patients to be admitted to hospital for 1 day (for low-grade splenic injuries-WSES Class I, AAST Grades I-II) to 3 days (for high-grade splenic injuries-WSES Classes II-III, AAST Grades III-V), with those with high-grade injuries requiring admission to a monitored setting. In the absence of specific complications, the panel suggests DVT and VTE prophylaxis with LMWH to be started within 48-72 h from hospital admission. The panel suggests splenic artery embolization (SAE) as the first-line intervention in patients with hemodynamic stability and arterial blush on CT scan, irrespective of injury grade. Regarding patients with WSES Class II blunt splenic injuries (AAST Grade III) without contrast extravasation, a low threshold for SAE has been suggested in the presence of risk factors for NOM failure. The panel also suggested angiography and eventual SAE in all hemodynamically stable adult patients with WSES Class III injuries (AAST Grades IV-V), even in the absence of CT blush, especially when concomitant surgery that requires change of position is needed. Follow-up imaging with contrast-enhanced ultrasound/CT scan in 48-72 h post-admission of trauma in splenic injuries WSES Class II (AAST Grade III) or higher treated with NOM was considered the best strategy for timely detection of vascular complications. CONCLUSION: This consensus document could help guide future prospective studies aiming at validating the suggested strategies through the implementation of prospective trauma databases and the subsequent production of internationally endorsed guidelines on the issue.

Published
2022

32. BDNF plasma concentrations, cognitive test performances and lifetime suicide ideation in psychotic disorders: a secondary analysis

Author

P. Paribello, M. Manchia, U. Isayeva, R. Collu, P. Federica, M. Scherma, C. Pisanu, A. Meloni, C. C. Zai, D. Congiu, A. Squassina, W. Fratta, P. Fadda, and B. Carpiniello

Subjects
Psychiatry, RC435-571
Abstract

Introduction Psychotic disorders present a significant lifetime risk for suicide. Past estimates suggest that up to 25-50% of individuals with schizophrenia (SCZ) may attempt suicide during their lifetime. A growing body of literature indicates that the level of cognitive performances may be associated with a differing level of lifetime suicide attempts, albeit inconsistently depending on the diagnostic category and study setting. However, the vast majority of the literature in the field is composed of cross-sectional studies, limiting the overall interpretation of the available evidence. Objectives In the present study, we probed the possible association of BDNF plasma levels, cognitive functions assessed through the Brief Assessment of Cognition in Schizophrenia (BACS) and lifetime suicide ideation and/or attempts (LSI+LSA). More specifically, we tested whether such association would persist during the 2 years follow-up divided in 5 different timepoints at 6-month intervals, if present. Methods The present study represents a secondary analysis of a previously described cohort (Manchia et al. Brain Sci. 2022 Dec 4;12(12):1666). The sample comprised 105 subjects with SZC or schizoaffective disorder. We employed the 1) Wilcoxon test for non-parametric data 2) linear modelling to test the possible association of BACS-defined cognitive task performances with LSI+LSA. We also investigated if either BDNF plasma levels or four tested BDNF SNP genes would mediate this association. Results From a total of 105 subjects, data relevant to the analysis were available for 89 subjects. We observed a significant association between BACS-Letter fluency task (BACS-LF) with LSI+LSA, persisting even when adjusting for gender, duration of untreated psychosis, total Positive and Negative Syndrome Scale score, age, chlorpromazine equivalents of antipsychotic therapy and for the effect of time. The association remained significant even when adjusting with the Bonferroni-Holms method for multiple comparisons (p=0.002). No association was found either for BDNF plasma levels or the tested BDNF genes for the tested outcomes. Conclusions In our sample, higher BACS-LF performances appeared to be associated with a higher lifetime risk of LSI+LSA. This report adds to the previous literature suggesting that different cognitive performance levels may represent one of the many chronic risk factors associated with LSI+LSA, and that may ultimately complexly interact with more proximal ones. Disclosure of Interest None Declared

Published
2024
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34. Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries

Author

Dönmez, A Eylül, Goswami, Aakansha Giri, Raheja, Aashna, Bhadani, Aayush, El Kady, Abd Elrahman Safwat, Alniemi, Abdalaziz, Awad, Abdalkarim, Aladl, Abdalla, Younis, Abdalla, Alwali, Abdallah, Khalil, Abdallah, Mansour, Abdallah, Elkhouly, Abdallah Mohamed, Rashad Temerik, Abdallah, Hasan, Abdallatef, Chied, Abdelhafid, Abdraba, Abdelhamid, Hrora, Abdelmalek, Abdelshafi, Abdelrahman, Alwali, Abdelrahman, Maraqa, Abdelrahman, Ghaffar, Abdul, Chekfa, Abdul Jabar, Al Balushi, Abdul Majeed, Quddus, Abdul, Hammadieh, Abdul Rahman, Muntaka, Abdul-Jalilu Mohammed, Asekun, Abdulazeez, Alshahrani, Abdulaziz, Jowharji, Abdulaziz, Alshukre, Abdulbaset, Khair Etareig, Abdulhafid, Abubakar Abdulkarim, Abdulhafiz, Ashiru, Abdulhafiz, Alailesh, Abdulhamid, Al-Mallah, Abdullah, Baydoun, Abdullah, Chaudhry, Abdullah, Askin, Abdullah Emre, Almutairi, Abdulmjeed, Belkhair, Abdulmunem, Abdllah, Abdulrahman, Alhammali, Abdulrahman, Basalim, Abdulrahman, Abouelnagah, Abdulrahman Galal Mohamed Mostafa, Ghazal, Abdulrahman, Mohammed, Abdulrahman, Qasem, Abdulrahman, Anadani, Abdulrazak, Jimoh, Abdulrazaq, Lawal, Abdulrazzaq Oluwagbemiga, Khaity, Abdulrhman, Lawal, Abdulwahab, Elzoubi, Abdurrahim Esseid, Sheshe, Abdurrahman Abba, Cetişli, Abdurrahman Furkan, Oyedele, Abeeb, Aljahdali, Abeer, Aboelnasr, Abeer Gamal Elsyed, Demessie, Abel, Bhargava, Abhilasha, Sonkar, Abhinav Arun, Bavaharan, Abhirame, Khan, Abid, Campbell, Abigail, Oyelekan, Abimbola Adeola Akintunde, Okunlola, Abiodun Idowu, Ojewuyi, Abiodun, Ekerin, Abiola, Saleh, Abobakr, Khairy, Abouelatta, Muthunayagam, Abraham Benjamin, Botha, Abraham, Teshome Sahilemariam, Abraham, Nawawi, Abrar, Muhammad, Abubakar Bala, Dahiru, Abubakar, Yahaya, Abubakar, Abdelmalik, Abubaker, Anuar, Abul Akmal Arif, Ousseini, Adakal, Leon -Del- Angel, Adalberto, Frankel, Adam, Gyedu, Adam, Lim, Adam, Lukáč, Adam, Peckham-Cooper, Adam, Sabbah, Adam, Varga, Adam, Sanou, Adama, Issaka, Adamu, Ningi, Adamu, Yeshitila, Addis, Yingess, Addisu, Olugbami, Adebayo, Moses, Damola-Okesiji, Adebola, Lawal, Adedayo, Ojo, Adedoyin, Hashmi, Adeel, Fakoya, Adegbolahan, Ishola, Adegoke, Abiodun, Adekunle, Ajayi, Adekunle, Mouffokes, Adel, Bonelli, Adele, Adekoya, Adeleke, Akeem Aderogba, Adeleke, Özcan, Adem, Ayoade, Ademidun, Adeyeye, Ademola, Agbaje, Ademola, Talabi, Ademola, Ademuyiwa, Adesoji, Adewumiya, Adesoji, Ademuyiwa, Adesoji O, Aderounmu, Adewale, Adisa, Adewale, Oke, Adewale, Ragab, Adham, Alzadjali, Adil, Baksi, Aditya, Jayapalan, Aditya, Md Yunos, Adnan, Pisanu, Adolfo, Salazar, Adolfo, Salinas Barragan, Adrian Alberto, Fox, Adrian, Stollberg, Adrian, Franco, Adriana, Neves, Adriana, Vricheva, Adriana, Hodonou, Adrien Montcho, Aghayeva, Afag, Liaquat, Affifa, Alsultan, Afnan, Morad, Afnan, Kalidis, Afroditi Angella, Gkouniaroudi, Agathi, Karakosta, Agathi, Lovi, Agbenya, Yevide, Agossou Barthélémy, Duro, Agustin, Rodriguez Gonzalez, Agustin, Tariq, Ahbala, Abaidalla, Ahmad, Abuhammad, Ahmad, Abuhantash, Ahmad, Mansour, Ahmad Adel, Ahmad Zaidi, Ahmad Al Hafeez, Alahmad Alismael, Ahmad, Alayed, Ahmad, Alfarwan, Ahmad, Alhaj, Ahmad, Ali, Ahmad, Alroobi, Ahmad, Alsheikh, Ahmad, Alusef, Ahmad, Alzu'Bi, Ahmad, Kayali, Ahmad Amir, Bouhuwaish, Ahmad, Doghaim, Ahmad, El-Sherbiney, Ahmad, Ghazal, Ahmad, Ramly, Ahmad Nasir, Raza, Ahmad, Qureshi, Ahmad Uzair, Arnaout, Ahmad Yamen, Abdelhamid, Ahmed, Abuthaher, Ahmed, Adel, Ahmed, Ahmayda, Ahmed, Al-Mouahhed, Ahmed, Alagha, Ahmed, Albalawi, Ahmed, Albhaisi, Ahmed, Alrifaee, Ahmed, Azam, Ahmed, Barakat, Ahmed, Al-Hajjaj, Ahmed Basim Abed, Dawoud, Ahmed, El Shamarka, Ahmed, El-Bastwesy, Ahmed, Elghrieb, Ahmed, Elkhalifa, Ahmed, Elmosalamy, Ahmed, Elshazli Mahmoud, Ahmed, Montaser, Ahmed G., Gbeadese, Ahmed, Haty, Ahmed, K. 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Chisom, Jamieson-Grigg, Chloe, Ong, Chon Sum, Alphonse, Chris, Bode, Chris, Varghese, Chris, Carrillo Sarango, Christian, Esteo Verdu, Christian, Krautz, Christian, Mosca, Christian, Nimbona, Christian, Nikolaou, Christina, Wiesner, Christina, Kloppers, Christo, Kourouniotis, Christoforos, Seiler, Christoph, Knee, Christopha, Mpirimbanyi, Christophe, Aboah, Christopher, Amah, Christopher, Cheong, Christopher, Harmston, Christopher, Leung, Christopher, Seet, Christopher, Smart, Christopher, Chouliaras, Christos, Damaskos, Christos, Doudakmanis, Christos, Kaselas, Christos, Limas, Christos, Ntagkas, Christos, Papazacharias, Christos, Stefanou, Christos, Thrasyvoulou, Christos, Tsalikidis, Christos, Karagianni, Chrysanthi, Kolla, Chrysoula-Christina, Ugwunne, Chuka, Ilo, Chukwudi, Nwegbu, Chukwuemeka, Onwuzu, Chukwuka, Weadick, Ciara, De Martino, Ciro, Donohoe, Claire, Gutierrez De La Rosa, Clara Elena, Florián Villa, Clara Marcela, Petcu, Clara Teodora, Cecconi, Claudia, Banal, Claudine, Brandi, Claudio, Hossu, Claudiu, Onuoha, Clement, Osime, Clement, Shelton, Clifford, Fuentes Orozco, Clotilde, Adumah, Collins, Dina, Constantin, Nastos, Constantinos, Aguero, Coral, Markin, Coretta, Hoogerboord, Cornelis, Da Lio, Corrado, Saviello, Cosimo, Bezede, Cosmin, Distefano, Costanza, Elliot-Wilson, Courtney, Bokossa, Covalic, Lupercio Figueroa, Cristian Israel, Riboni, Cristiana, Meola, Cristiano, Costa, Cristina, Gas, Cristina, Larotonda, Cristina, Soddu, Cristina, Vacca, Cristina, Vera Mansilla, Cristina, Li, Crystal, Agbonrofo, Cynthia, Akli-Nartey, Cynthia, Molewa, Cynthia, Nelly Rosine, Cyuzuzo Ngwije, Rega, D., Koike, Daisuke, Wickramasinghe, Dakshitha, Clarke, Damian, Fry, Damian, Hannedige, Damsadie, Powell, Dan-Beck, Kasasbeh, Dana, Samardali, Dana, Sharl Ajami, Dani, Badran, Dania, Adjei, Daniel, Muhie, Daniel Ahmed, Pérez Muñoz, Daniel Alejandro, Alifoe, Daniel, Aparicio-López, Daniel, Baños Méndez, Daniel, Cristian, Daniel, Eaton, Daniel, Gero, Daniel, Makary, Daniel, Montwedi, Daniel, Muñoz, Daniel, Patterson, Daniel, Reim, Daniel, Agbley, Daniel Yao Dodzie, Patiño García, Daniela Cristina, Di Pietrantonio, Daniela, Pais, Daniela, Rosado, Daniela, Tavares, Daniela, Alberti, Daniele, Fusario, Daniele, Massaro, Daniele, Paglione, Daniele, Pironi, Daniele, Kurochka, Daniil, Centonze, Danilo Corrado, Hackner, Danilo, Herrera, Danilo, Amangaliyev, Daniyar, Silva-Cano, Danny Wladimir, Chaudhry, Daoud, Palmisano, Dario, Ribero, Dario, Vukosav, Dario, Misca, Darius, Lowen, Darren, Rattray, Darren, Walia, Darshanjit Singh, Maan, Darvesh, Muyenzi, Daryle, Verdi, Daunia, Bardsley, David, Reyes Rodríguez, David Estuardo, Fra Corral, David, Garcia López De Goicoechea, David, Gavit, David, Gómez, David, Idowu, David, Konkin, David, Labadah, David Kplorla Kekeli, Liu, David, Merlini, David, Mitchell, David, Moro-Valdezate, David, Osifo, David, Proud, David, Ridder, David, Gobatti, Davide, Muschitiello, Davide, Pertile, Davide, Zulian, Davide, Mengiste, Dawit, Mikami, Dean, Mohanty, Debajyoti, Chatterjee, Debarghya, Komolafe, Deborah Olaitan, Scotto Di Carlo, Deborah, Wright, Deborah, Rahme, Deema, Talreja, Deep Parkash, Jain, Deepak, Rajput, Deepak, Singh, Deepak, Anbu, Deepika, Ibrahim, Dena, Phom, Denchu, Hili, Denise, Osei, Dennis Broni, Daary, Dennis, Kyeremeh, Dennis, Shen, Dennis, Uymaz, Derya Salim, Cianflocca, Desiree, Ashitey, Desmond, Evripidou, Despo, Papageorgouli, Despoina, Kaushal, Devesh, Abeysirigunawardana, Dewmi, Dugar, Dharmendra, Mallik, Dhiraj, Ghosh, Dhruva, Houmran, Diaa, Abdulrahman, Diala, Pantoja Pachajoa, Diana Alejandra, Cardona Gomez, Diana Catalina, Fenner, Diana, Gonzalez, Diana Samantha, Siriwardena, Diana, Garcés Palacios, Diana Sofía, Stoian, Diana, Zuikyte, Diana, Sosa Méndez, Dianne Alitzá, Wickramarathna, Dickson, Mutter, Didier, Palma Portillo, Diego Andrés, Chavez Fernandez, Diego, Córdova García, Diego, Enjuto, Diego, Giulitti, Diego, Sasia, Diego, Visconti, Diego, Yiğit, Dilara, George, Dilip, Rabaia, Dima, Georgiev, Dimitar, Hadzhiev, Dimitar, Alexandrou, Dimitrios, Balalis, Dimitrios, Giakoustidis, Dimitrios, Manatakis, Dimitrios K., Korkolis, Dimitrios, Lytras, Dimitrios, Massaras, Dimitrios, Moris, Dimitrios, Politis, Dimitrios, Sampanis, Dimitrios, Schizas, Dimitrios, Tsiardas, Dimitrios, Vardakostas, Dimitrios, Kotsaris, Dimitris, Khattab, Dina Hesham, M. Awad, Dina, Alrokh, Dina Sami, Schippers, Dina, Waleed, Dina, Salinovic, Dinko, Gonçalves Múrias Gomes, Diogo Miguel, Silva, Diogo, Vaz Acosta, Diogo, Morton, Dion, Panagopoulos, Dionisios, Kelgiorgi, Dionysia, Dellaportas, Dionysios, Prevezanos, Dionysios, Joshi, Dipti, Ozal, Direm, Yigit, Direnc, Chimkaomasiri, Divine, Jabbar, Diya, Nepogodiev, Dmitri, Belekar, Dnyanesh, Abdalaziz, Doaa, Abunemer, Doaa, Attia, Doaa, Elkafrawy, Doaa, Dimitrov, Dobromir, Pignatelli, Domenica, Merlicco, Domenico, Soriero, Domenico, Zerbo, Domenico, Atouguia, Domingas, Fairbrass, Dominic, T. Enti, Donald, Venskutonis, Donatas, Rukavina, Dora, Caruso, Dorena, Herappe, Dorihela, Lee, Dorinda Norbetha, Ofosuhene, Doris, Hajela, Apoorva, Badwan, Basem, Kulkarni, Datta, Dhawan, Deep, Dhillon, Jeevanjit, Mehmood, Manzer, Mahmood, Namrah, Nikam, Narendra, Ramchandani, Radhakrishna, Thind, Ravinder Singh, Riazhussain, D Hafiz, Maqsood, Saliha, Alalawi, Yousef, Tyagi, Harshdeep, Kshirsagar, Shivani, Ahmed, Hisham, Juan Carlos, Luna Cydejko, Kone, Dramane, Omar, Duaa, Alves, Duarte Gil, Subasinghe, Duminda, Ommi, Durgesh, Joshiba, Durshney, Chakarov, Dzhevdet, Arkoh, Ebenezer Ameyaw, Frimpong-Manso, Ebenezer, Ada, Ece, Lincango, Eddy P., Lozada Hernandez, Edgard Efren, Hodžić, Edin, Di Marco, Edith, Baccalini, Edoardo Andrea, Baldini, Edoardo, González Marín, Eduardo, Gutierrez, Eduardo, Sepúlveda, Eduardo, Dainius, Edvinas, Zhang, Edward, Yenli, Edwin Mwintiereh Ta-Ang, Antoniou, Efstathios, Kapasakis, Efstathios, Baili, Efstratia, Poulios, Efthymios, Kubiliute, Egle, Osaze, Ehioghae, Afeikhena, Ehis, Elshennawy, Eiad, Athanasopoulou, Eirini, Synekidou, Eirini, Ekaladze, Eka, Tampaki, Ekaterini Christina, Adam, Elaf, Adel Hamdoun Aziz, Elaf, Yousuf, Elamin, Gialamas, Eleftherios, Spartalis, Eleftherios, Bedzhanyan, Elen, Toma, Elena Adelina, Daukšaitė, Elena, Desiato, Elena, Dvivedi, Elena, Hadzhieva, Elena, Martí Cuñat, Elena, Montalbán Martínez, Elena, Montanari, Elena, Signaroli, Elenasofia, Efremidou, Eleni, Gavriil, Eleni, Karakeke, Eleni, Mavrodimitraki, Eleni, Papamattheou, Eleni, Jose, Elenza, Cianci, Eleonora, Ciccioli, Eleonora, Daleva, Eleonora, Locci, Eleonora, Lori, Eleonora, Silanos, Eleonora, Ayala, Elí, Bankart, Eliana, Brolese, Eliane, Efstathiou, Elias, Salloum, Elias, Colak, Elif, Terzi, Elif Didem, Ametefe, Elikem, Cagigal Ortega, Elima Pilar, Donnarumma, Elio, Mina, Elisa, Reitano, Elisa, Wallner, Elisabeth, Moggia, Elisabetta, Betz, Elise, Kontis, Elissaios, Anestiadou, Elissavet, Gimson, Eliza, Lun, Elizabeth, Fraser, Elizabeth, Li, Elizabeth, Torres De Anda, Elizabeth Magaly, Murphy, Elizabeth Mary Ann, O'Connell, Elizabeth, Redondo, Elizabeth, Lun, Elizabeth Weng Yan, Francis, Ella, Haiden, Elmar, Hamed, Elmonzir, Alkhalifa, Elmustafa, Dexter, Eloise, Daketsey, Elorm, Setsoafia, Elorm, Mohamed, Elsagad, Mohammed, Elsamoual, Hegab, Elsayed, Ay, Elvin, Adinolfi, Elvira, Mbanzabugabo, Elvis, Chin, Elynn, Ahmed, Emad Ali, Younes, Eman, Basile, Emanuela, Gessa, Emanuela, Pontecorvi, Emanuele, Romairone, Emanuele, Hatangimana, Eméry, Ndizeye, Emile, Ciofic, Emilia, Dijan, Emilio, López-Negrete Cueto, Emilio, Baker, Emily, Reid, Emily, Schmidt, Emily, Alić, Emir, Bičakčić, Emir, Agbowada, Emma, Colton, Emma, Downing, Emma, Haege, Emma, O'Neill, Emma, Roussos, Emmanouel, Nachelleh, Emmanuel Aadereyir, Adebunmi, Emmanuel, Obiesie, Emmanuel Ahuizechukwu, Akakpo, Emmanuel Bismark, Konlan, Emmanuel Dammigu Francis, Nwangwu, Emmanuel Ifeanyi, Kafui Ayodeji, Emmanuel, Ofori, Emmanuel Owusu, Spanoudakis, Emmanuel, Abate, Emmanuele, Balik, Emre, Bozdağ, Emre, Bozkurt, Emre, Karabulut, Emre Cagri, Ozoran, Emre, Tunçcan, Emre, Tuzuner, Emre, Halilović, Emsad, Alabed, Enaam, Zidan, Enas, Hodžić, Enes, Aybar, Engin, Yildirim, Engin Okan, Wong, Enoch, Yhoshu, Enono, Bisogno, Enrica, Andolfi, Enrico, Ferri, Enrico, Potenza, Enrico, Spalice, Enrico, Volpin, Enrico, González, Enrique, Downes, Eoin, Gallo, Erdachew, Kamer, Erdinc, Naidoo, Eressa, Erginöz, Ergin, Bara, Eric, Irungu, Eric, García-Villegas, Eric Yusif, Mazzotta, Erica, Monati, Erica, Chan, Erick, Gómez Mejía, Erika, Dylja, Eris, Somuncu, Erkan, Yavuz, Erkan, Begunić, Ernes, Margelis, Ernest, Osei, Ernest Owusu, Saitoglou, Ertzan, Agastra, Ervis, Mazumdar, Eshan, Soyer Güldoğan, Esra, Abu Siam, Esra'A, Abdelbaset, Esraa, Abdu, Esraa, Adel Mahmod Sultan, Esraa, Nubi Mohamed, Esraa Gamal, Abuobaida Banaga Hag El Tayeb, Essam Eldien, Ali, Essraa, Page-Taylor, Estelle, Marra, Ester, Garcia Santos, Esther Pilar, Elsheikh, Ethar, Unal, Ethem, Tan, Eugene, De Leo, Eugenio, Borges, Eva, Gáspár, Éva, Ruiz-Daum, Eva, Apostolopoulos, Evaggelos, Samara, Evangelia, Barkolias, Evangelos, Fradelos, Evangelos, Hopping, Eve, Romo Ascencio, Evelia Veronica, Sosa Ferreira, Ever David, Shestakov, Evgenii, Tyurina, Evgenya, Hristova, Evguenia, Efthymiou, Evripidis, Tokidis, Evripidis, Harrison, Ewen, Dontoh, Ewurama Akroma, Mansour, Eyad, Yeshialem, Eyosiyas, Dabbagh, Ezeddin, Amer, Ezzeldin, Manasci, Fabiana, Gomes, Fabio, Medas, Fabio, d'Acapito, Fabrizio, Vassallo, Fabrizio, Haddad, Fadi, Elhabishi, Fadwa, Akhtar, Fahad, Tauheed, Fahad, Al Abbood, Fahd, Gareb, Fahed, Ghazali, Fairuz, Alnazawi, Faisal, Ondago, Faith, Rasoaherinomenjanahary, Fanjandrainy, Wiese, Fanny, González Ponce, Fanny Yesenia, Georgiades, Fanourios, Ali, Farah, Galley, Fareeda, Huda, Farhanul, Amir, Farhat Naaz, Ashraf, Fariha, Alfarsi, Faris, Ayasra, Faris, Ali, Farman, Mahmoud, Faten, Aliskander, Fater, Tahir Lwdie, Fathea, Buyuker, Fatih, Aguilar Del Castillo, Fátima, Mohammed Daoud, Fatima Ahmed, Alowjaly, Fatima, Oni, Fatima, Rauf, Fatima, Elkhafeefi, Fatimah, Hourri, Fatine, Monib, Fatma A., Alshreef, Fatma, Benghalbon, Fatma, Ntirenganya, Faustin, Ashraf, Fauziyah, Chahrour, Fayez, Ahmad, Fazal, Parray, Fazlul Qadir, Philips, Febi, Campus, Federica, Di Marco, Federica, Ferraina, Federica, Frongia, Federica, Maffeis, Federica, Natali, Federica, Pederiva, Federica, Scolari, Federica, Tofani, Federica, Marin, Federico Alberto Niccolò, Biolchini, Federico, Cappellacci, Federico, Corronca, Federico, Mazzola, Federico, Suldrup, Federico, Nyarko, Felicia, Casas J, Felipe, Zapata, Felipe, Aigner, Felix, Alakaloko, Felix, Amoako, Felix, Camacho, Felix, Hammett, Felix, Kuubetersob B. N, Felix, Alahmad, Feras, Alnimri, Feras, Haddad, Feras, Gool, Ferhana, Castro, Fernanda, Diaz, Fernanda, Lucero, Fernanda, Vovola, Fernanda, Mahnic, Fernando, Mercado Sanchez, Fernando, Prieto La Noire, Fernando, Soggiu, Fiammetta, Tsige, Fikreab, Brzeszczyński, Filip, Rudisch, Filip, Valente Costa Pinto, Filipa, Ramalho De Almeida, Filipe, Banchini, Filippo, Palomino Escalante, Fiorella, Fadzlullah, Fitri, Terefe, Fitsum, Sulo, Fjorenta, Ciccarone, Flavia, Tirelli, Flavio, Krämer, Florian, Grama, Florin, Spanos, Foivos, Solimene, Folco, Akinwande, Foluso, Osman, Forzia, Stefou, Foteini, Kyramargios, Fotios, Stavratis, Fotios, Alassani, Fousseni, Ascari, Francesca, Cammelli, Francesca, D'Agostino, Francesca, Tropeano, Francesca Paola, Peters, Francesca, Ré, Francesca, Brucchi, Francesco, Casti, Francesco, Coratti, Francesco, Ferrara, Francesco, Floris, Francesco, Izzo, Francesco, Maffei, Francesco, Palmieri, Francesco, Pata, Francesco, Porcelli, Francesco, Selvaggi, Francesco, Velluti, Francesco, Mulita, Francesk, Bello, Francis, Caiquo, Francis, Dossou, Francis, Eshun, Francis Junior, Opoku Twene, Francis, Tierenye, Francis, Quayson, Francis William, Romo Rosales, Francisco David, Ibañez Ortiz, Francisco, León Frutos, Francisco Javier, Redondo Calvo, Francisco Javier, Silva Rivera, Francisco Javier, Barbosa Camacho, Francisco José, Bujalance Cabrera, Francisco Manuel, Ruescas, Francisco, Irakiza, Franck Fanon, Corvatta, Franco, Pascual, Franco Raúl, Roviello, Franco, Roodt, Francois, Gyamfi, Frank Enoch, Olaniru, Frank, Owusu, Frank, Bader, Franz G., Anzinger, Franz-Xaver, Agbodo, Fred David Anku, Ris, Frederic, Agbemafoh, Frederick Mawuli, Afonso, Frederico, Nazareth, Frederico, Berrevoet, Frederik, Hounde, Fréjus, Demiral, Furkan, Hassooni, Furqan Ridha Hassooni, Kafa, Gabi, Cárdenas Rivera, Gabriel, Ntwari, Gabriel, Szydlo Shein, Gabriel, Ambriz González, Gabriela, Nita, Gabriela Elisa, Bellio, Gabriele, Moitzi, Gabriele, Urdang, Gabriella, Marom, Gad, Gallo, Gaetano, Luglio, Gaetano, Poillucci, Gaetano, Singh, Gagandeep, Saletta, Gaia, Abouelnagah, Galal, Yarovenko, Galina, Kazobinka, Gallina, Ahmed, Gamal Mutwakil Gamal, Rahman, Ganiyu Adebisi, Smith, Garett, Pillai, Gargi, Saxena, Garima, Gbessi, Gaspard, Nkunguzi, Gaston, Jalal, Gaurav, Chillarge, Gauri, Singh, Gautam, Mevognon, Gedeon, Getachew, Gedion, George, Gejoe, De La Peña González, Gema, Martínez Izquierdo, Gema, Grande, Gennaro, Birikorang, Geoffrey, Weber, Georg F., Singer, Georg, Ansong, George, Bashour, George, Brown, George Darko, Hneino, George, Kavalieratos, George, Kenchadze, George, Nagy, George, Pappas Gogos, George, Skroubis, George, Waiyaki, George, Cox, Georgia, Zeringa, Georgia, De Wee, Georgin, Hart, Georgina, Bekakos, Georgios, Fragulidis, Georgios, Kapogiannatos, Georgios, Karakaidos, Georgios, Kokkinos, Georgios, Kostoulas, Georgios, Koukoulis, Georgios, Peros, Georgios, Rados, Georgios, Tsoulfas, Georgios, Verras, Georgios-Ioannis, Berger, Geraint, Adoro, Gerard Ayuka, Chamoso Mialdea, Gerardo, Palmieri, Gerardo, Procaccini, Gerardo, Steenkamp, Gerhard, Viscido, Germán Rodrigo, Dajti, Gerti, Alemayehu, Getachew, Seyfu, Gezachew, Birqeeq, Ghada, Alsheikh, Ghadeer, Alrayyes, Ghaith, El Hunjul, Ghalib Nashaat, Zaza, Ghayath, Matroud, Ghazlah, Alhadwah, Ghena, Maltinti, Gherardo, Awais, Ghina, Shamsi, Ghina, Calini, Giacomo, Carganico, Giacomo, Zanus, Giacomo, Canu, Gian Luigi, Mendiola, Gian, Ibero Casadiego, Giana Pamela, Cocorullo, Gianfranco, Baronio, Gianluca, Pellino, Gianluca, Zanni, Gianluca, Poto, Gianmario Edoardo, Gravante, Gianpiero, Aduroja, Gideon, Almogy, Gidon, Bond-Smith, Giles, Natchagande, Gilles, Bechara, Gio, Brachini, Gioia, Riccioli, Giordana, Ercolani, Giorgio, Farris, Giorgio, Giraudo, Giorgio, Mammolo, Giovanna, Pavone, Giovanna, Sgarzini, Giovanna, Aprea, Giovanni, Fonsi, Giovanni Battista, Boroni, Giovanni, De Angeli, Giovanni, De Palma, Giovanni Domenico, Emiliani, Giovanni, Grava, Giovanni, Guercio, Giovanni, De Carlo, Giulia, Del Corpo, Giulia, Duranti, Giulia, Galatioto, Giulia, Grassi, Giulia, Graziano, Giulia, Marini, Giulia Maria Francesca, Munzi, Giulia, Tarantino, Giulia, Borda-Luque, Giuliano, Pellicano', Giuseppe Antonino, Canonico, Giuseppe, Carollo, Giuseppe, Ietto, Giuseppe, Palomba, Giuseppe, Pascarella, Giuseppe, Salamone, Giuseppe, Sica, Giuseppe, Sorrentino, Giuseppe, Orlando, Giuseppina, Pignata, Giusto, Pisarevi, Givi, Akcakoca, Gizem, Owusu, Godfred, Yohanna Abrak, Godwin, Kurtoglu, Gokalp Kagan, Kurtoglugk, Gokalp Kagan, Alıcı, Gökhan, Kurtoglu, Goktug Mert, Delgado Hernandez, Gonzalo, Augustin, Goran, Bhat, Gowhar Aziz, Sundaram Venkatesan, Gowtham, Chang, Grace, Eke, Grace, Lee, Grace, Massarra, Grace, Travaglini, Grazia, Scialandrone, Grazisa, Stavrou, Gregor A., Di Franco, Gregorio, Charalambous, Gregory, Christodoulidis, Gregory, Kouraklis, Gregory, Goodwin, Gregory Richard, Devidze, Grigol, Fialho, Guilherme, Santos, Guilherme, Cabezudo, Guillermo, García-Santos, Guillermo, Pou, Guillermo, Romero Reyna, Guillermo, Yanowsky-Reyes, Guillermo, Ozyuksel, Gul, Karadeniz Cakmak, Guldeniz, Kucuk, Gultekin Ozan, Bulbuloglu, Guney Cem, Sarp, Guray, Kaur, Gurleen, Nibogora, Guy Darcy, Hamdan, Gymar, Ogundipe, Habeeb, Yunes, Habib, Ayesh, Hadeel, Al Atassi, Hadi, Jalilehvand, Hadis, Masalma, Hafez, Jafarkhan, Hafis, Shahid, Hafiz Huzaifa, Younus, Hafsa, Al-Derume, Hail, Shames, Haitam, Mimouni, Haithem Ahmed, Aldare, Hajar, Odah Bashi, Hajar Omar, Abusnina, Hajer, Altounsi, Hajir, Qayum, Hajra, Baysal, Hakan, Bolukbasi, Hakan, Yigitbas, Hakan, Alkhatib, Hala, Afzal, Haleema, Mftah, Halima, Oyinlola, Halimah, Tümer, Haluk, Dolo, Hamadoun, Braham, Hamdi, Ozsahin, Hamdi, Abu-Arish, Hamdoon, Al-Aamri, Hamed, Fadlalmola, Hammad Ali, Abu Obead, Hamza, Al-Fahel, Hamza, Al-Zoubi, Hamza, Asaad, Hamza, Ejaz, Hamza, Jaber, Hamza, Bhatti, Hamza Waqar, Mohammadi Sardoo, Hamzeh, Farhat, Hana, Idheiraj, Hanadi, Zwaraa, Hanady, Al Sohabi, Hanan, Basharat, Hanan, Said, Hanan, Al-Abdallat, Haneen, Foad, Haneen, Daaboul, Hanen, Al Qadhi, Hani, Elhallaq, Hani, Alhusaini, Hanin, Lidbetter, Hannah, Reilly, Hannah, Moya- Ambriz, Hannia Betzabeth, Lederhuber, Hans, Fehrer, Hans-Jörg, Xiao, Haotian, Iswariah, Harish, Kaur, Harmeena, Cheema, Harnoor Kaur, Foda, Haroun, Chauhan, Harpreet, Kaur, Harpreet, Sagar, Harry, Unwin, Harry, Kaur, Harsharan, Panga, Harshavardhan, Gupta, Harshit, Prabhakar, Harshit Kumar, Anand, Harshitha, Pahwa, Harvinder Singh, Abbadi, Hasan, Amoudi, Hasan, Zaini, Hasan Hadi Zaini, Škiljo, Hasan, Miyasika, Hasangi, Altabbaa, Hashem, Haj Freej, Hasn, Abdelazim, Hassan, Habiba, Hassan, Kamal, Hassan, Sabir, Hassan, Zaigham, Hassan, Pehlivan, Hatice, Telci, Hatice, Abuobaida, Hayat, Tetley, Heather, Taher, Heba, Aguado López, Héctor, Askarpour, Hedyeh, Sherif Farouk Ahmed Hassan, Heidi, Devesa, Helena, Arbogast, Helmut, Nuñez Del Barrio, Henar, Abiyere, Henry, Delacave, Henry, Rice, Henry E., Pleass, Henry, Bradly, Hera, Islam, Heraa, Lule, Herman, Abozied, Hesham, Le Roux, Hettie, Hamdar, Hiba, Yaghmour, Hiba, Bileid Bakeer, Hibah, Al Miskry, Hilal, Ulman, Hilmican, Abdoun, Hind, Essalim, Hind, Yonekura, Hiroshi, Kato, Hiroyuki, Amin-Tai, Hizami, Kynaston, Holly, Pérez Baca, Honorio De Jesús, Irfan Khan, Hoor, Amir, Hosam, Elghadban, Hosam, Elfeki, Hossam, Wain, Howard, Adjei, Hubert, Dąbrowski, Hubert, Novák, Hubert, Alzuhd, Huda, Capote, Hugo, Gomez-Fernandez, Hugo, Stark, Hugo, Willy-Chidire, Hulda, Aouagbe Behanzin, Hulrich, Oneizah, Humam M.A., Dalati, Husam, Ebied, Husam, Mahajna, Husam, Ahmad, Husnain, Altawati, Husni, Adi, Hussam, Albalawi, Hussam, Alfakeer, Hussein, Embarek, Hussein, Ibrahim, Hussein, Malkawi, Hussein, Ekwuazi, Hyginus, Psilopatis, Iason, Wasiu, Ibitowa, Kereet, Ibraheem M., Suleiman, Ibrahem, Fortune, Ibrahim, Aburumman, Ibrahim, Adel, Ibrahim, Adham, Ibrahim, Ali, Ibrahim, Arnaout, Ibrahim, Çakır, Ibrahim, Suleiman, Ibrahim Eneye, Fagiri, Ibrahim, Hajmohammed, Ibrahim, 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Bertrand, Martin, Dum, Martin, Kajic, Martin, Karamanliev, Martin, Kyereh, Martin, Lucchini, Martin, Schön, Martin, Morna, Martin Tangnaa, Binda, Martina, Ceolin, Martina, Martorana, Martina, Zambon, Martina, Shams, Marvi, Alansary, Marwa, Alnuwayli, Marwa, Khalifa, Marwa, Bahnacy, Marwan, Iqreewi, Marway, Nnabagulanyi, Mary, Saleem, Marya, Alhimyar, Maryam, Kamal, Maryam, Masood, Maryam, Razaq, Maryam, Siddique, Maryam, Lazo Ramírez, Maryzela, Edeeb, Masaoud, Solkar, Maseera, Adetoyi, Mashood, Adeniyi, Caccetta, Massimiliano, Casati, Massimiliano, Veroux, Massimiliano, Dugo, Massimo, Bevanda, Mateo, Santillan, Mateo, Mietła, Mateusz, Pryt, Mateusz, Muir, Mathew, Bei, Matilda, McGuinness, Matt, Aulicino, Matteo, Castrovillari, Matteo, Filardo, Matteo, Palmeri, Matteo, Pisano, Matteo, Rottoli, Matteo, Gjoka, Mattheus, Binks, Matthew, Corcos, Matthew, Kwon, Matthew, Maybury, Matthew, Sammut, Matthew, Tutton, Matthew, Watson, Matthew, Biebl, Matthias, Janda, Matthias, Maak, Matthias, Wichmann, Matthias, Berselli, Mattia, Gritti, Mattia, Molteni, Mattia, Pacilli, Maurizio, Favoriti, Mauro, Garino, Mauro, Podda, Mauro, Santarelli, Mauro, Alfaid, Mawada, Albert, Mawadri Jimmy Isaac, Oyortey, Mawuenyo Attawa, Enßlin, Max, Berlet, Maximilian, Brunner, Maximilian, Kießler, Maximilian, Scheiterle, Maximilian, Sohn, Maximilian, Busch, Maximiliane, Perkins, Maya, Sabboh, Maya, Badkur, Mayank, Okudero, Mayowa, Mohamedshafee, Maysoon, Al-Juaifari, Maytham Aqeel, Elesseily, Mazen, Mohammad, Mazen, Nikberg, Maziar, Jean Claude, Mbonicura, Şermet, Medeni, Chisthi, Meer, Luthra, Meera, Sulciner, Megan, Kaple, Meghali, Bhat, Meghana, Koç, Mehmet Ali, Avci, Mehmet Alperen, Kizilkaya, Mehmet Celal, Kara, Mehmet Emin, Ozcelik, Mehmet Faik, Ozsoy, Mehmet Sait, Zaigham, Mehreen, Mesfin, Mekdelawit, Kalender, Mekselina, Mellado Tellez, Mel Paul, González De Miguel, Melania, Farrugia, Melanie, Theodoridou, Melanie, Barcelona, Melden Darrell, Aktas, Melik Kagan, Fernández Zurita, Melissa Andrea, Bautista, Melissa, Park, Melissa, Rodríguez-Ordoñez, Melissa-Zohemia, Yashar, Meltem, Worku, Mengistu, Al-Fraijat, Meran, Estaire Gómez, Mercedes, Shoshkova, Meri Danailova, Kruščica, Merima, Tanal, Mert, Çuhadar, Merve, Tokocin, Merve, Agyapong, Meshach Manu, Erkaya, Metincan, Okechukwu, Mgbako, Adinku, Michael, Bickford, Michael, Ediale, Michael, Issa, Michael, Konstantinidis, Michael K., Lie, Michael, M. Nathan, Michael, Maclean, Michael, Nortey, Michael, Pellen, Michael, Pham, Michael, Pitiakoudis, Michael, Singh, Michael Prodip, Spartalis, Michael, Van Der Colf, Michael, Wilson, Michael, Billis, Michail, Karanikas, Michail, Papamichail, Michail, Vailas, Michail, Kisielewski, Michał, Kusiński, Michał, Nycz, Michał, Święch, Michał, Fagbayimu, Micheal, Adamina, Michel, Fiogbe, Michel, Prudhomme, Michel, Angelucci, Michela, Campanelli, Michela, Cricrì, Michele, Grande, Michele, Manigrasso, Michele, Scopelliti, Michele, George, Michelle, Mozel, Michelle, Galasyuk, Mick, Chevallay, Mickael, Giuliano, Micol, Dobón Rascón, Miguel Ángel, Fernandez Romero, Miguel Angel, García Ureña, Miguel Ángel, Zaragoza Mendieta, Miguel Ángel, Bejarano Serrano, Miguel, Brito, Miguel, Calderon, Miguel, Jurado Román, Miguel, Palas, Miguel, Li Valencia, Miguel Roberto, Sebastián-Mendoza, Miguel-Julián, Muresan, Mihai-Stefan, Slavchev, Mihail, Agapov, Mikhail, Milentijević, Milica, Catterall, Millie, Stjepanovic, Milos, Doss, Mina, Natey, Mina, Aikins, Minas, Mattis, Minca, Ekanayake, Minoli Tharushika, Tora, Mir Mehrab Sharmin, Alsharayri, Mira, Shalaby, Mira, Boras, Miran, Riba Martínez, Mireia, Mogiatti, Mirella, Salibašić, Mirhan, Biancu, Miriam, Cappiello, Miriam, Koschke, Miriam Luise, Sadek, Mirna, Szura, Miroslaw, Horga, Miruna, Dason, Mishael, Tayyab, Mishal, Imirski, Mitko, Pejović, Mladen, Tabaza, Mo'Ath, Alneasan, Moaaz, Shalkamy, Moamen, Issa, Moammad Issa, Erfan, Moatasem, Ewedah, Moataz, Srour, Moayad, Beletachew, Moges, Abbas, Mohamad, Farho, Mohamad Ali, Marawy, Mohamad Kher, Klib, Mohamad, Morjan, Mohamad, Sawas, Mohamad Nabhan, Elghriani, Mohamed Abdelbaset Masoud, Abdelmaboud, Mohamed, Abdelmaksoud, Mohamed, Abdullahi, Mohamed, Abo Abdo, Mohamed, Ahmed, Mohamed, Ahmoud, Mohamed, Al Sayed, Mohamed, Suliman, Mohamed Almouafaq, Alsori, Mohamed, Altajouri, Mohamed, Assalhi, Mohamed, Berrakkouch, Mohamed, Elnour, Mohamed, Abdelsalam, Mohamed Elsayed Elaraby Abdelrahim, Elsayed Metwally, Mohamed, Hajalamin, Mohamed, Kamal Matter, Mohamed, Khaled, Mohamed, Kouta, Mohamed, Masoud, Mohamed, Almihashhish, Mohamed Miftah, Mokhtar, Mohamed, Mostafa, Mohamed, Yassin, Mohamed Musa, Bouhafs, Mohamed Nedjmeddine, Herdan, Mohamed Omar, Omer, Mohamed, Osman, Mohamed, Zaazou, Mohamed, Zahed Abdalla, Mohamed, Melouane, Mohamed-Sami, Abed, Mohammad, Sawaftah, Mohammad Ahmad Mohammad, Al-Masri, Mohammad, Al-Qannas, Mohammad, Ali-Hassanzadeh, Mohammad, Yunus, Mohammad Alif, Aloulou, Mohammad, Alrantisi, Mohammad, Araydah, Mohammad, Bani Hani, Mohammad, Barakat, Mohammad, Durrani, Mohammad, Khan, Mohammad Faisal, Dwikat, Mohammad Fuad, Hasan, Mohammad, Nabhan, Mohammad Hassan, Hijazi, Mohammad, Abu Albahrain, Mohammad Karam, Barakat, Mohammad Mounzer, Mubarak, Mohammad, Omar, Mohammad, Pourfridoni, Mohammad, Mslmani, Mohammad Rabee, Salah, Mohammad, Tanashat, Mohammad, Yahmad, Mohammad, Elmujtaba, Mohammed, Abd Al-Fattah, Mohammed, Abdelkabir, Mohammed, Abosedra, Mohammed, Sarker, Mohammed Abu Kawsar, Abudabbous, Mohammed, Abuwarda, Mohammed, Elgak, Mohammed Ahmed, Al Hinai, Mohammed, Al Zebda, Mohammed, Al-Shehari, Mohammed, Alharthi, Mohammed, Ali, Mohammed, Ismael Alamin, Mohammed Ali, Alqadasi, Mohammed, Alshanwani, Mohammed, Alshehri, Mohammed, Asaad, Mohammed, Bashir, Mohammed, Bohlala, Mohammed, Meghaizerou, Mohammed El Amine, Albanna, Mohammed Emad Hashem, Ghunaim, Mohammed, Goga, Mohammed, Hajhamad, Mohammed, Hamada Takrouney, Mohammed, Hammoda, Mohammed, Hamoud Almahly, Mohammed, Muragi, Mohammed, Mohammed, Mohammed Mustafa Hassan, Obaid, Mohammed, Omar, Mohammed, Said, Mohammed, Salah, Mohammed, Saleh Khatab, Mohammed, Aliyu, Mohammed Salele, Shakhshir, Mohammed, Sheriff, Mohammed, Tageldin, Mohammed, Abdelfattah, Mohanad, Daher, Mohanad, Lotfy, Mohanad, Alqedrh, Mohannad, Nasani, Mohannad, Mohd Shah, Mohd Shahrulsalam, Madany, Mohie El-Din Mostafa, Mobolaji-Ojibara, Mojisola, Nkogatse, Moleseng, Alazabi, Mona, Gupta, Money, Bogdan, Monica, Guerrero, Monica, Noguez Castillo, Monica, Gureh, Monika, Kacem, Montasser Jamaleddine, Tarar, Moosa Feroze, Seto, Morel, Steinruecke, Moritz, Edena, Morrison, Abdulsalam, Moruf, Abdelhadi Suliman Adam, Mosab, Saleh, Mosab, Anati, Mosaikah, Dokurugu, Moses Abdulai, Agunloye, Moses, Ibadin, Moses, Momoh, Moses, Abdelkarim, Mostafa, Kamar, Mostafa, Kotb, Mostafa, Mahran, Mostafa, Mohamad Amin, Mostafa, Shalaby, Mostafa, Waseem, Mostafa, Almaletti, Motasem, Saifi, Motaz, Tsuruta, Motohisa, Agbadebo, Mouhamed, Arnaout, Moumen, Ojo, Moyosoluwa, Sharma, Mrthyunjayani, Azzuz, Muad Mohamed Ramadan, Haj Hussein, Mudar, Ameen, Muftiat Omolola, Nkoronko, Mugisha, Fitri, Muhamad, Abdullah, Muhammad, Bashir, Muhammad Ahmad, Sadiq, Muhammad Ahmad, Ahmed, Muhammad, Ali, Muhammad, Al-Yusuf, Muhammad Ali, Haider, Muhammad Aliyan, Alshaar, Muhammad, Mirza, Muhammad Bilal, Che Yaacob, Muhammad, Daniyan, Muhammad, Elzayat, Muhammad, Butt, Muhammad Faizan, Sadiq, Muhammad Hamza, Chishti, Muhammad Haris, Ismail, Muhammad Izzat Shufphi, Kashif, Muhammad, Khalid, Muhammad, Mansoor Iqbal, Muhammad, Bin Khalid, Muhammad Moaz, Rafique, Muhammad Nouman, Raheem, Muhammad, Khalid, Muhammad Saud, Usama, Muhammad, Usman Malik, Muhammad, Saqib, Muhammad Waleed, Elhadi, Muhammed, Ateş, Muhammed Ikbal, Demirpolat, Muhammed Taha, Ergenç, Muhammer, Bello, Muideen, Kulimbet, Mukhtar, Nyirenda, Mulinda, Taeme, Mulugeta, Denini, Muna, Aziz, Munazzah, Yahaya, Mundashiru, Eugene, Muneza, Amadu, Munira, Chauhan, Munish, Acar, Murat, Teressa, Murti, Dauphin, Muryango, Arafat, Musa, Althomali, Musab, Rayzah, Musaed, Husain, Musharraf, Tolani, Musliu Adetola, Abu Jayyab, Mustafa, Al-Attraqchi, Mustafa, Kara, Mustafa Alper, Seker, Mustafa Ege, Gün, Mustafa, Hamed, Mustafa, Mehanny, Mustafa, Oncel, Mustafa, Sabri Massadi, Mustafa, Uyanik, Mustafa Safa, Uzunoglu, Mustafa Yener, Abdullahi, Mustapha, Saidani, Mustapha, Nofal, Mutaz, San, Myat, Ishak, Myrna, Keramida, Myrto D., Nik Burhanuddin, N.M. Syahrin, Talat, Nabila, Shehata, Nada, Alasbahi, Nadeen, Marcos, Nádia, Al Amri, Nadiah, Absy, Nadine, Parker, Naeelah, Lindi, Naeimah, Omer, Nafisa, Papadogianni, Nafsika, Rawal, Nagendra, Ismaiel, Nahar, Ben Hasan, Najat, Albahloul, Najla, Gokhare Viswanath, Nakul, Srinivas, Namitha, Christian, Nana Ama, Obuobi, Nana Kwame Asare, Beharry, Naomi, Yousefzadeh Kandevani, Naser, Alnamari, Nashwan, Oyelowo, Nasir, Oloko, Nasirudeen, Alzerwi, Nasser, Mosbah, Nasser, Shulman, Nastassia, Andrade, Natacha, Boumas, Natacha, Cobeño Tamayo, Natalia, Barrera Lopez, Natalia Guadalupe, Palamara, Natalia, Blencowe, Natalie, Marzouqa, Natalie, Blencowe, Natalie S, Salgadoe, Natalie, Techapongsatorn, Nathakorn, Paez, Nathaly, Ekwo, Nathan, Saini, Navdeep, Malik, Naveed Akhtar, Sharma, Naveen, Kumar, Navin, Chaudhry, Navneet Kumar, Karimbocus, Nawaaz, Rasool, Nazeerah, Lodhi, Nazia, Kavak, Nazli, Ildephonse, Ndayiragije, Diomede, Nduwimana, Bayleyegn, Nebiyou S., S.Bayleyegn, Nebiyou, Jović, Nediljko, 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Nikolaos, Memos, Nikolaos, Michalopoulos, Nikolaos, Mathioudakis, Nikolaos Nestor, Roukounakis, Nikolaos, Stamos, Nikolaos, Tasis, Nikolaos, Tsakiridis, Nikolaos, Vlachakos, Nikolaos, Zampitis, Nikolaos, Kouzakos, Nikolas, Börner, Nikolaus, Dimitriou, Nikoletta, Dafnios, Nikos, Banerjee, Niladri, Klammer, Nils, Maharjan, Nima, Rabai, Nimah, Oscar, Nimpaye, Harrison, Nina, Kheyrbek, Nina, Kansakar, Nirajan, Bhat, Nisar, Krishnappa, Nischal, Pahuja, Nisha, Paul Ambrose, Nitin, Renovat, Niyongabo, Musawa, Nizar, Nwanne, Njideka, Steve, Nkurunziza, Chidumije, Nnaemeka, Nwafulume, Nnaemeka, Celestine, Nnamani, Duru, Nnamdi, López Bernal, Noelia Esthela, Laquatra, Noemi, Pasqua, Noemi, Awwad, Noor Al-Deen, Ali, Nora, Hielscher, Nora, Trabulsi, Nora, Hüser, Norbert, Muñoz Montes, Norberto, Eshak, Norma-Sol, Rajab, Nosaiba, Lahnaoui, Nouhaila, Ouachou, Nouhaila, Ali, Nour, Dadoush, Nour, Fazili, Noureen, Theophile, Ntahompagaze, Ntanzi, Ntuthuko, Bibila, Nubia Samuel, Alwaer, Nuhay, Naabo, Nuhu, Jiagge, Nuna, Freitas Oliveira, Nuno Miguel, Pratas, Nuno, Morricone, Nunzia, Franco, Nunzio Francesco, Binti Yusri, Nur Aima, Ramli, Nur Natasya, Abd Ghani, Nur Suriyana, Umar, Nura, Aly, Nuran Khaled, Lakhanov, Nurgali, Al-Hroub, Nurhan, Kiziltoprak, Nurhilal, Chavarrias, Nuria, Maulenov, Nurlan, Akinbami, Nurudeen, Abdulraheem, Nurudeen Toyin, Karunaratne, Nuwanthika, Jeannette, Nyiransabiyera, Altobaishat, Obieda, Egwuonwu, Ochonma Amobi, Enciu, Octavian, Cohen-Arazi, Oded, Pheiffer, Odette, Okoye, Odili Aloysius, Omoike, Ofure, čančar, Ognjen, Ekwunife, Okechukwu Hyginus, Emuze, Okundayo, Eljizoly, Ola Abdallah, Al Hamdani, Ola, Emadeldeen, Ola, Morgan, Ola, Olajumoke, Oladapo, Popoola, Olakunle, Ajiboye, Olalekan, Olasehinde, Olalekan, Jolayemi, Olamide, Babatunde, Olanrewaju, Balogun, Olanrewaju, Olajide, Olawumi, Lisin, Oleg, Bellou, Olga, Jurić, Oliver, Ladlow, Oliver, Whitehurst, Oliver, Camilleri, Olivia, Montaño Angeles, Olivia, Pryer, Olivia, Ray, Olivia, Gabom, Olivier, Ndizeye, Olivier, Ojewuyi, Olufemi, Oluyemi, Olukayode, Elebute, Olumide, Ogunsua, Oluseyi, Fasiku, Olushola Kayode, Fasoro, Olusola, Fatudimu, Oluwafemi, Osunlusi, Oluwafemi, Owolanke, Oluwagbenga, Oso, Oluwarotimi, Alaba, Oluwaseun, Ojo, Oluwaseun, Oluseye, Oluwaseun, Oyinloye, Oluwaseun, Al Alyani, Omaima, Okrah, Omane, Agha, Omar, Al-Fahel, Omar, Almomani, Omar, Alruwaili, Omar, Ibarra, Omar, Ibrahim, Omar, Khalil, Omar, Kouli, Omar, Lima Azurdia, Omar, Mansour, Omar, Mohamed Mokbel, Omar, Omar, Omar, Bedak, Omer, Ozkan, Omer Faruk, Yalkın, Omer, Mohamed, Omnia, Ayandipo, Omobolaji, Faboya, Omolara, Williams, Omolara Modupe, Irowa, Omorodion, Attawodi, Onuche, Salako, Opeyemi, Ioannidis, Orestis, Agcaoglu, Orhan, Martin Sole, Oriol, Webster, Orla, Abouhiekal, Osama, Al Shaqran, Osama, Bahsas-Zaky, Osama, Nubi, Osama Gamal, Hany, Osama, Matar, Osama, Mahafdah, Osama R., Sarhan, Osama, Osagie, Osasumwen, Soublett Rivas, Óscar Alexander, Gülcicek, Osman Bilgin, Cuenca Torres, Osmar Manuel, Carpineto Samorani, Osvaldo, Arsalan, Othman, Coyoy-Gaitán, Otto, Nouhail, Oumaima, Boujidi, Oumama, Dicko, Ousmane A A, Ahmad, Owais, Christianah, Oyegbola, Küpçüoğlu, Özge, Zanbak Mutlu, Özgecan Pırıl, Chadha, P, Prabhu, P Santosh, Carmignani, Pablo, Arteaga Asensio, Pablo Cesar, Del Val Ruiz, Pablo, Royo Dachary, Pablo, Sancho Pardo, Pablo, Vásquez, Pablo, Sukhvibul, Pakkapol, Assouto, Pamphile, Evangelou, Panagiota, Dorovinis, Panagiotis, Kapsampelis, Panagiotis, Kokoropoulos, Panagiotis, Kostoglou, Panagiotis, Manikis, Panagiotis, Sakarellos, Panagiotis, Lykoudis, Panagis, Kumar, Pankaj, Patel, Panna, Paraskeva, Panoraia, Vassiliu, Panteleimon, Antonakis, Pantelis, De Nardi, Paola, Marongiu, Paola, Kamenova, Paolina, Venturelli, Paolina, Belotti, Paolo, Ubiali, Paolo, Grivas, Paraskevas, Stamopoulos, Paraskevas, Chatzikomnitsa, Paraskevi, Trakosari, Paraskevi, Tekam Wadje, Parfait Stéphane, Manjunath, Parikshith, Gupta, Pariza, Dhamija, Parth, Haque, Parvez, Haque, 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2024
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35. A machine learning predictive model for recurrence of resected distal cholangiocarcinoma: Development and validation of predictive model using artificial intelligence

Author

Perez, Marc, Palnaes Hansen, Carsten, Burdio, Fernando, Sanchez-Velázquez, Patricia, Giuliani, Antonio, Lancellotti, Francesco, de Liguori-Carino, Nicola, Malleo, Giuseppe, Marchegiani, Giovanni, Podda, Mauro, Pisanu, Adolfo, De Luca, Giuseppe Massimiliano, Anselmo, Alessandro, Siragusa, Leandro, Kobbelgaard Burgdorf, Stefan, Tschuor, Christoph, Cacciaguerra, Andrea Benedetti, Koh, Ye Xin, Masuda, Yoshio, Hao Xuan, Mark Yeo, Seeger, Nico, Breitenstein, Stefan, Grochola, Filip Lukasz, Di Martino, Marcello, Secanella, Luis, Busquets, Juli, Dorcaratto, Dimitri, Mora-Oliver, Isabel, Ingallinella, Sara, Salvia, Roberto, Abu Hilal, Mohammad, Aldrighetti, Luca, and Ielpo, Benedetto

Published
2024
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37. Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes

Author

Tamil Selvi Sundaram, Maria Filippa Addis, Carlotta Giromini, Raffaella Rebucci, Salvatore Pisanu, Daniela Pagnozzi, and Antonella Baldi

Subjects
Medicine, Science
Abstract

Abstract Omega-3 polyunsaturated fatty acids (n-3 PUFA), such as the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are reported to beneficially affect the intestinal immunity. The biological pathways modulated by n-3 PUFA during an infection, at the level of intestinal epithelial barrier remain elusive. To address this gap, we investigated the proteomic changes induced by n-3 PUFA in porcine enterocyte cell line (IPEC-J2), in the presence and absence of lipopolysaccharide (LPS) stress conditions using shotgun proteomics analysis integrated with RNA-sequencing technology. A total of 33, 85, and 88 differentially abundant proteins (DAPs) were identified in cells exposed to n-3 PUFA (DHA:EPA), LPS, and n-3 PUFA treatment followed by LPS stimulation, respectively. Functional annotation and pathway analysis of DAPs revealed the modulation of central carbon metabolism, including the glycolysis/gluconeogenesis, pentose phosphate pathway, and oxidative phosphorylation processes. Specifically, LPS caused metabolic dysregulation in enterocytes, which was abated upon prior treatment with n-3 PUFA. Besides, n-3 PUFA supplementation facilitated enterocyte development and lipid homeostasis. Altogether, this work for the first time comprehensively described the biological pathways regulated by n-3 PUFA in enterocytes, particularly during endotoxin-stimulated metabolic dysregulation. Additionally, this study may provide nutritional biomarkers in monitoring the intestinal health of human and animals on n-3 PUFA-based diets.

Published
2023
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38. Groundwater temperature measurement of Chiang Mai basin

Author

Chanakan Wisessan, Pisanu Wongpornchai, Fongsaward Suvagondha Singharajwarapan, Nattaporn Chaiyat, and Pimwaree Thitiwatthanakarn

Subjects
groundwater, temperature-depth, vapor compression refrigerant, chiang mai, Technology, Technology (General), T1-995, Science, Science (General), Q1-390
Abstract

Groundwater temperature is one of the main factors that is considered when deciding on installation of a vapor compression refrigeration system with groundwater used for heat transfer. Groundwater temperature measurement is a necessity for the system installation. A total of 75 groundwater wells within the Chiang Mai Basin were selected for temperature monitoring stations. The temperature-depth profile of shallow groundwater showed that temperature had little change below 2 m depth from the water table. The temperature-depth profile of deep groundwater showed the separation of upper and lower temperature zones. Mostly, the temperature of the upper zone of deep groundwater has a positive slope. The temperature of the lower zone of deep groundwater is relatively constant. Both the shallow and deep groundwater temperatures are below the atmospheric temperature. The seasons, hydrogeologic units, and land use types have affected groundwater temperature of the Chiang Mai Basin only little.

Published
2023

39. A Secondary Analysis of the Complex Interplay between Psychopathology, Cognitive Functions, Brain Derived Neurotrophic Factor Levels, and Suicide in Psychotic Disorders: Data from a 2-Year Longitudinal Study

Author

Pasquale Paribello, Mirko Manchia, Ulker Isayeva, Marco Upali, Davide Orrù, Federica Pinna, Roberto Collu, Diego Primavera, Luca Deriu, Edoardo Caboni, Maria Novella Iaselli, Davide Sundas, Massimo Tusconi, Maria Scherma, Claudia Pisanu, Anna Meloni, Clement C. Zai, Donatella Congiu, Alessio Squassina, Walter Fratta, Paola Fadda, and Bernardo Carpiniello

Subjects
psychotic disorders, suicidal behaviour, cognitive functions, BDNF, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Identifying phenotypes at high risk of suicidal behaviour is a relevant objective of clinical and translational research and can facilitate the identification of possible candidate biomarkers. We probed the potential association and eventual stability of neuropsychological profiles and serum BDNF concentrations with lifetime suicide ideation and attempts (LSI and LSA, respectively) in individuals with schizophrenia (SCZ) and schizoaffective disorder (SCA) in a 2-year follow-up study. A secondary analysis was conducted on a convenience sample of previously recruited subjects from a single outpatient clinic. Retrospectively assessed LSI and LSA were recorded by analysing the available longitudinal clinical health records. LSI + LSA subjects consistently exhibited lower PANSS-defined negative symptoms and better performance in the BACS-letter fluency subtask. There was no significant association between BDNF levels and either LSI or LSA. We found a relatively stable pattern of lower negative symptoms over two years among patients with LSI and LSA. No significant difference in serum BDNF concentrations was detected. The translational viability of using neuropsychological profiles as a possible avenue for the identification of populations at risk for suicide behaviours rather than the categorical diagnosis represents a promising option but requires further confirmation.

Published
2024
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41. Tackling challenges in rare diseases: The ISGACA approach on non-pancreatic cancers in the periampullary region

Author

Berger, Adam C., Alseidi, Adnan, Pisanu, Adolfo, Ramirez-Del Val, Alejandro, Serrablo, Alejandro, Anselmo, Alessandro, Ferrero, Alessandro, Giani, Alessandro, Mazzotta, Alessandro, Zerbi, Alessandro, Moekotte, Alma, Zureikat, Amer H., Cacciaguerra, Andrea Benedetti, de Wilde, Anouk, Koerkamp, Bas Groot, Ielpo, Bennedetto, Björnsson, Bergthor, Al, Bilal, Sarireh, Goh, Brian K.P., Gayet, Brice, Ball, Chad G., Vollmer, Charles M., Tang, Chung N., van Dam, Coen, Ricci, Claudio, Droogh, Daphne, Korkolis, Dimitris, Sparrelid, Ernesto, Ausania, Fabio, di Benedetto, Fabrizio, Lancelotti, Francesco, Berrevoet, Frederik, Kazemier, Geert, Nappo, Gennaro, Poya, Ghorbani, Marchegiani, Giovanni, Fusai, Giuseppe Kito, Malleo, Giuseppe, Seppanen, Hanna, Wilmink, Hanneke, Han, Ho-Seong, Frigerio, Isabella, Halle, James, Christein, John D., Kleeff, Jorg, de Vos Geelen, Judith, Johansen, Karin, Roberts, Keith J., Hayek, Kevin el, Khalil, Khalid, Webber, Laurence, Siragusa, Leandro, Bolm, Louisa, Maglione, Manuel, Ramaekers, Mark, Giuffrida, Mario, Gruppo, Mario, Serradilla, Mario, Ramaeckers, Mark, Fontana, Martina, Guerra, Martina, Dillhoff, Mary E., Mortimer, Matthew C.M., House, Michael G., Mazzola, Michele, Suarez Muñoz, Miguel Angel, Vladimirov, Miljana, Luyer, Misha, Bonds, Morgan, Kerem, Mustafa, Napoli, Niccolò, Mowbray, Nicholas, Jamieson, Nigel B., Soubrane, Olivier, Pessaux, Patrick, Mauro, Podda, Valle, Raffaele Dalla, Zheng, Richard, Casadei, Riccardo, Bhogal, Ricky, Salvia, Roberto, Salem, Ronald R., Cabús, Santiago Sánchez, Koek, Sharnice, Delis, Spiros, Bouwense, Stefan, Dreyer, Stephan, Behrman, Stephen W., White, Steven, Robinson, Stuart, Mieog, Sven, S.Kent, Tara, Vanagas, Tomas, Boggi, Ugo, Wellner, Ulrich, Mavroeidis, Vasileios K., Fisher, William E., Koh, Ye Xin, Soonawalla, Zahir, Uijterwijk, Bas A., Lemmers, Daniël H., Moekotte, Alma L., Zaniboni, Alberto, Ghidini, Michele, Milella, Michele, Scarpa, Aldo, Luchini, Claudio, Baboeram, Nigel, Klei, Dorine S., Manzoni, Alberto, Bannone, Elisa, Oneda, Ester, Besselink, Marc G., and Abu Hilal, Mohammed

Published
2024
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42. IRON: A retrospective international multicenter study on robotic versus laparoscopic versus open approach in gallbladder cancer

Author

Ielpo, Benedetto, Vittoria d’Addetta, Maria, Burdio, Fernando, Sanchez-Velazquez, Patricia, Vellalta, Gemma, Cremona, Simone, Villamonte, Maria, Morelli, Luca, Furbetta, Niccoló, Di Franco, Gregorio, Comandatore, Annalisa, Mastrangelo, Mattia, Mazzone, Chiara, Masetti, Michele, Offi, Maria Fortuna, Geraldi, Eleonora, Aldrighetti, Luca, Ingallinella, Sara, Ratti, Francesca, Rosso, Edoardo, De Blasi, Vito, Anselmo, Alessandro, Conte, Luigi Eduardo, Memeo, Riccardo, Delvecchio, Antonella, Sukandy, Iswanto, Moraldi, Luca, Grazi, Gian Luca, Spampinato, Marcello G., D'Ugo, Stefano, Heng Chiow, Adrian Kah, Yi Yee, Francis Zheng, Tan, Hiang Jin, Thiruchelvam, Nita, Lancellotti, Francesco, Satyadas, Thomas, Fedi, Massimo, De Vincenti, Rosita, Leo, Francesca, Pesi, Benedetta, Belli, Andrea, Izzo, Francesco, Cutolo, Carmen, Romano, Fabrizio, Scotti, Mauro Alessandro, Carissimi, Francesca, Garancini, Mattia, Ciulli, Cristina, Mazzola, Michele, Ferrari, Giovanni, Zironda, Andrea, Giani, Alessandro, Giuliani, Giuseppe, Federica Dorma, Maria Pia, Guerra, Francesco, Di Marino, Michele, Coratti, Andrea, Mina, Elisa, Romanzi, Andrea, Prieto, Mikel, Perfecto, Arkaitz, Ioannidis, Orestis, Lombardeas, Odysseas, Ardito, Francesco, Giuliante, Felice, Lopez-Lopez, Victor, Robles-Campos, Ricardo, Martinie, John, Mccarron, Frances, Romito, Raffaele, Nicolosi, Filadelfio Massimiliano, Ben Dhaou, Anis, Chamekh, Atef, Rezgui, Bochra, Pacilli, Mario, Pavone, Giovanna, Tartaglia, Nicola, Gupta, Rahul, Grego, Davide Giovanni, Ricci, Claudio, Pata, Francesco, Nardo, Bruno, Facundo, Helena, Guevara, Oscar, Lorenzin, Dario, Guglielmi, Alfredo, Ruzzenente, Andrea, Valle, Valentina, Alberto, Mangano, Giulianotti, PierCristoforo, Vicente, Emilio, Ferri, Valentina, Avella, Pasquale, Calise, Fulvio, Rocca, Aldo, Bianchi, Paolo, Rompianesi, Gianluca, Troisi, Roberto I., Donadon, Matteo, di Martino, Marcello, Podda, Mauro, Pisanu, Adolfo, Torzilli, Guido, Vittoria d'Addetta, Maria, Di Martino, Marcello, and Giulianotti, Pier Cristoforo

Published
2024
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43. Symptomatic remission and recovery in major psychosis: Is there a role for BDNF? A secondary analysis of the LABSP cohort data

Author

Isayeva, Ulker, Manchia, Mirko, Collu, Roberto, Primavera, Diego, Deriu, Luca, Caboni, Edoardo, Iaselli, Novella Maria, Sundas, Davide, Tusconi, Massimo, Pinna, Federica, Paribello, Pasquale, Scherma, Maria, Pisanu, Claudia, Meloni, Anna, Zai, Clement C., Congiu, Donatella, Squassina, Alessio, Fratta, Walter, Fadda, Paola, and Carpiniello, Bernardo

Published
2024
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46. Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Montrreal, Laura, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Franco-Macías, Emilio, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Frank-García, Ana, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-Madrona, Sebastián, García-González, Pablo, Alarcón-Martín, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Pérez-Cordón, Alba, Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Martín Montes, Angel, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Abdelnour, Carla, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., and Ruiz, Agustín

Published
2023
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47. Do Long-Acting Injectable Antipsychotics Influence Serum Levels of Brain-Derived Neurotrophic Factor in People With Schizophrenia and Schizoaffective Disorder?

Author

Mirko Manchia, Ulker Isayeva, Roberto Collu, Diego Primavera, Luca Deriu, Edoardo Caboni, Maria Novella Iaselli, Davide Sundas, Massimo Tusconi, Clement C. Zai, Maria Scherma, Alessio Squassina, Donatella Congiu, Pasquale Paribello, Federica Pinna, Claudia Pisanu, Anna Meloni, Walter Fratta, Paola Fadda, and Bernardo Carpiniello

Subjects
Psychiatry, RC435-571
Abstract

Schizophrenia (SCZ) and schizoaffective disorder (SAD) are severe and complex psychiatric disorders whose liability threshold is modulated by the interplay of biological, mainly genetic, and environmental factors. Consistent evidence has pointed to the role of serum brain-derived neurotrophic factor (BDNF) as a plausible illness biomarker in SCZ spectrum disorders. There is no consensus, however, on the temporal trajectory of this decline. Here, we present a secondary analysis of the Longitudinal Assessment of BDNF in Sardinian Psychotic patients (LABSP) study, focusing on the impact of antipsychotic therapy, particularly long-acting injectable (LAI), on the longitudinal trajectory of serum BDNF levels and analyzing the effect of BDNF genetic variants. LABSP patients were assessed every 6 months for a series of measures, including the assessment of BDNF serum levels over 24 months. Blood samples for each patient were taken at the same time of the day (between 8:00 and 10:00 a.m.). BDNF serum levels were determined using the BDNF ELISA Kit. Four tag single nucleotide polymorphisms (SNPs) within the BDNF gene (rs1519480, rs11030104, rs6265 [Val66Met], and rs7934165) were selected using standard parameters and analyzed with polymerase chain reaction (PCR). Mixed-effects linear regression models (MLRMs) were used to analyze longitudinal data. Twenty-four patients out of 105 LABSP (22.9%) patients received therapy with LAI. Analysis with MLRM showed a significant effect of LAI treatment associated with increasing serum BDNF levels (Z=2.2, p=0.02). However, oral antipsychotics did not significantly impact the longitudinal trajectory of serum BDNF levels (Z=0.15, p=0.9). There was no moderating effect of variants within the BDNF gene on the identified association. We identified a significant longitudinal increase in serum BDNF in SCZ and SAD patients treated with LAI antipsychotic therapy. The significant impact of this preparation of antipsychotic treatment on serum BDNF, despite the limited sample size, points to a moderate to large magnitude of effect that should be investigated in future prospective studies.

Published
2024
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48. Uncommon finding in a pulmonary graft versus host disease: A first report of Tsukamurella pneumonia in a pulmonary graft-versus-host disease

Author

F.R. Bertuccio, N. Baio, V. Chino, S. Montini, P. Putignano, L. Pisanu, M. Siciliano, J. Bagnarino, V. Monzillo, D. Barbarini, V. Conio, A. Cascina, G. Stella, and A.G. Corsico

Subjects
Tsukamurella, Pneumonia, Immunocompromised, Multidisciplinary team discussion, Gene sequencing, Graft versus host disease, Infectious and parasitic diseases, RC109-216
Abstract

A 64-year-old woman presented to Our Department with 2 weeks history of fever and cough. Through a series of radiological and invasive diagnostic studies we finally reach an unexpected diagnosis of Tsukamurella pneumonia; Diagnosing an ILD is a dynamic process, and that is the reason why complex cases discussed in a multidisciplinary team may need to be reconsidered in light of evolution of the disease and the results of the performed exams with a flexible approach. Tsukamurella spp. is an obligate aerobic, Gram-positive, weakly acid-fast, non-motile bacillus that belongs to the order Actinomycetales. Pneumonia caused by Tsukamurella is exceedingly rare, and only few cases are reported in the literature. Our aim is to evidence the paramount importance of Multidisciplinary team discussion in deciding the most appropriate diagnostic is of and therapeutical strategy.

Published
2024
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49. An integrated precision medicine approach in major depressive disorder: a study protocol to create a new algorithm for the prediction of treatment response

Author

Bernhard T. Baune, Alessandra Minelli, Bernardo Carpiniello, Martina Contu, Jorge Domínguez Barragán, Chus Donlo, Ewa Ferensztajn-Rochowiak, Rosa Glaser, Britta Kelch, Paulina Kobelska, Grzegorz Kolasa, Dobrochna Kopeć, María Martínez de Lagrán Cabredo, Paolo Martini, Miguel-Angel Mayer, Valentina Menesello, Pasquale Paribello, Júlia Perera Bel, Giulia Perusi, Federica Pinna, Marco Pinna, Claudia Pisanu, Cesar Sierra, Inga Stonner, Viktor T. H. Wahner, Laura Xicota, Johannes C. S. Zang, Massimo Gennarelli, Mirko Manchia, Alessio Squassina, Marie-Claude Potier, Filip Rybakowski, Ferran Sanz, and Mara Dierssen

Subjects
major depressive disorder (MDD), treatment resistant depression (TRD), antidepressant treatment response, genomics, transcriptomics, predictive algorithm, Psychiatry, RC435-571
Abstract

Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the most common option among the first-line treatment choice; however, only about one third of patients respond to the first trial and about 30% are classified as treatment-resistant depression (TRD). TRD is associated with specific clinical features and genetic/gene expression signatures. To date, single sets of markers have shown limited power in response prediction. Here we describe the methodology of the PROMPT project that aims at the development of a precision medicine algorithm that would help early detection of non-responder patients, who might be more prone to later develop TRD. To address this, the project will be organized in 2 phases. Phase 1 will involve 300 patients with MDD already recruited, comprising 150 TRD and 150 responders, considered as extremes phenotypes of response. A deep clinical stratification will be performed for all patients; moreover, a genomic, transcriptomic and miRNomic profiling will be conducted. The data generated will be exploited to develop an innovative algorithm integrating clinical, omics and sex-related data, in order to predict treatment response and TRD development. In phase 2, a new naturalistic cohort of 300 MDD patients will be recruited to assess, under real-world conditions, the capability of the algorithm to correctly predict the treatment outcomes. Moreover, in this phase we will investigate shared decision making (SDM) in the context of pharmacogenetic testing and evaluate various needs and perspectives of different stakeholders toward the use of predictive tools for MDD treatment to foster active participation and patients’ empowerment. This project represents a proof-of-concept study. The obtained results will provide information about the feasibility and usefulness of the proposed approach, with the perspective of designing future clinical trials in which algorithms could be tested as a predictive tool to drive decision making by clinicians, enabling a better prevention and management of MDD resistance.

Published
2024
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50. Lung consolidation in a young-age active smoker: An unexpected diagnosis

Author

F.R. Bertuccio, N. Baio, V. Chino, V. Ferroni, S. Montini, L. Pisanu, A. Cascina, V. Conio, A.G. Corsico, and G.M. Stella

Subjects
Hypersensitivity pneumonitis, Interstitial lung diseases, Multidisciplinary-team discussion, Diseases of the respiratory system, RC705-779
Abstract

A 29-year-old man presented to Emergency Department with nonspecific symptoms. Through a series of radiological and invasive diagnostic studies we finally reach an unexpected diagnosis of hypersentivity pneumonitis; this is a complex and heterogeneous disease which diagnosis can be challenging as its clinical, radiologic and histopathologic features overlap with those of other interstitial lung diseases (ILDs). Diagnosing an ILD is a dynamic process, and that is the reason why complex cases discussed in a multidisciplinary team may need to be reconsidered in light of evolution of the disease and the results of the performed exams with a flexible approach.

Published
2024
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