34 results on '"Pisanu, M."'
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2. Language production impairments in patients with a first episode of psychosis
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Gargano, G, Caletti, E, Perlini, C, Turtulici, N, Bellani, M, Bonivento, C, Garzitto, M, Siri, F, Longo, C, Bonetto, C, Cristofalo, D, Scocco, P, Semrov, E, Preti, A, Lazzarotto, L, Gardellin, F, Lasalvia, A, Ruggeri, M, Marini, A, Brambilla, P, Bertani, M, Bissoli, S, De Santi, K, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, M, Ballarin, M, De Girolamo, G, Fioritti, A, Neri, G, Pileggi, F, Rucci, P, Chiavetto, L, Scasselatti, C, Zanardini, R, Bertoldo, A, Marinelli, V, Rambaldelli, G, Bardella, S, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosi, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefani, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, C, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Aldi, F, Bianchi, B, Cappellari, P, Conti, R, De Battisti, L, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visona, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Santonastaso, P, Cremonese, C, Veronese, A, Anderle, P, Angelozzi, A, Baron, I, Candeago, E, Castelli, F, Chieco, M, Di Costanzo, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanzi, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, De Risio, A, Gatto, A, Grana, S, Favero, E, Franceschini, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Di Bortolo, E, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, Dominoni, A, Andreose, L, Boemio, M, Bressan, L, Cabbia, A, Canesso, E, Cian, R, Dal Piccol, C, Pasqua, M, Di Prisco, A, Mantellato, L, Luison, M, Morgante, S, Santi, M, Sacillotto, M, Scabbio, M, Sponga, P, Sguotto, M, Stach, F, Vettorato, M, Martinello, G, Dassie, F, Marino, S, Cibiniel, L, Masetto, I, Cabianca, O, Valente, A, Caberlotto, L, Passoni, A, Flumian, P, Daniel, L, Gion, M, Stanziale, S, Alborino, F, Bortolozzo, V, Bacelle, L, Bicciato, L, Basso, D, Navaglia, F, Manoni, F, Ercolin, M, Giubilini, F, Imbesi, M, Leuci, E, Mazzi, F, Anelli, S, Amore, M, Bigi, L, Britta, W, Anna, G, Bonatti, U, Borziani, M, Crosato, S, Fabris, I, Galluccio, R, Galeotti, M, Gozzi, M, Greco, V, Guagnini, E, Pagani, S, Maccherozzi, S, Malvasi, R, Marchi, F, Melato, E, Mazzucchi, E, Marzullo, F, Pellegrini, P, Petrolini, N, Volta, P, Bonara, F, Brusamonti, E, Croci, R, Flamia, I, Fontana, F, Losi, R, Marchioro, R, Raffaini, L, Ruju, L, Saginario, A, Tondelli, M, Marrama, D, Bernardelli, L, Bonacini, F, Florindo, A, Merli, M, Nappo, P, Sola, L, Tondelli, O, Tonna, M, Torre, M, Tosatti, M, Venturelli, G, Zampolla, D, Bernardi, A, Cavalli, C, Cigala, L, Ciraudo, C, Di Bari, A, Ferri, L, Gombi, F, Leurini, S, Mandatelli, E, Maccaferri, S, Oroboncoide, M, Pisa, B, Ricci, C, Poggi, E, Zurlini, C, Malpeli, M, Colla, R, Teodori, E, Vecchia, L, D'Andrea, R, Trenti, T, Paolini, P, Carpeggiani, P, Ghigi, D, Gagliostro, M, Pratelli, M, Antonelli, A, Battistini, L, Bellini, F, Bonini, E, Capelli, C, Didomizio, C, Drei, C, Fucci, G, Gualandi, A, Grazia, M, Losi, A, Mazzoni, F, Marangoni, D, Monna, G, Morselli, M, Oggioni, A, Oprandi, S, Paganelli, W, Passerini, M, Piscitelli, M, Reggiani, G, Rossi, G, Salvatori, F, Trasforini, S, Uslenghi, C, Veggetti, S, Bartolucci, G, Baruffa, R, Bertelli, R, Borghi, L, Ciavarella, P, Paltrinieri, E, Rizzardi, F, Serra, P, Suzzi, D, Arienti, P, Aureli, F, Avanzi, R, Callegari, V, Corsino, A, Host, P, Michetti, R, Rizzo, F, Simoncelli, P, Soldati, E, Succi, E, Bertozzi, M, Canetti, E, Cavicchioli, L, Ceccarelli, E, Cenni, S, Marzola, G, Gallina, V, Leoni, C, Olivieri, A, Piccolo, E, Ravagli, S, Russo, R, Tedeschini, D, Verenini, M, Abram, W, Granata, V, Curcio, A, Guerra, G, Granini, S, Natali, L, Montanari, E, Pasi, F, Ventura, U, Valenti, S, Francesca, M, Farneti, R, Ravagli, P, Floris, R, Maroncelli, O, Volpones, G, Casali, D, Miceli, M, Bencini, A, Cellini, M, De Biase, L, Barbara, L, Charles, L, Pratesi, C, Tanini, A, Loparrino, R, Ulivelli, C, Cussoto, C, Dei, N, Fumanti, E, Pantani, M, Zeloni, G, Bellini, R, Cellesi, R, Dorigo, N, Gulli, P, Ialeggio, L, Pisanu, M, Rinaldi, G, Konze, A, Cocchi, A, Meneghelli, A, Frova, M, Monzani, E, Zanobio, A, Malagoli, M, Pagani, R, Barbera, S, Morganti, C, Amade, E, Brambilla, V, Montanari, A, Caterina, G, Lopez, C, Marocchi, A, Moletta, A, Sberna, M, Cascio, M, Scarone, S, Gargano G., Caletti E., Perlini C., Turtulici N., Bellani M., Bonivento C., Garzitto M., Siri F. M., Longo C., Bonetto C., Cristofalo D., Scocco P., Semrov E., Preti A., Lazzarotto L., Gardellin F., Lasalvia A., Ruggeri M., Marini A., Brambilla P., Bertani M. E., Bissoli S., De Santi K., Lunardi S., Negretto V., Poli S., Tosato S., Zamboni M. G., Ballarin M., De Girolamo G., Fioritti A., Neri G., Pileggi F., Rucci P., Chiavetto L. B., Scasselatti C., Zanardini R., Bertoldo A., Marinelli V., Rambaldelli G., Bardella S., Lamonaca D., Lunardon M., Magnabosco R., Martucci M., Nicolau S., Nifosi F., Pavanati M., Rossi M., Piazza C., Piccione G., Sala A., Sale A., Stefani B., Zotos S., Balbo M., Boggian I., Ceccato E., Dall'Agnola R., Girotto B., Goss C., Leoni R., Mai A., Pasqualini A., Roccato S., Rossi A., Strizzolo S., Urbani A., Aldi F., Bianchi B., Cappellari P., Conti R., De Battisti L., Lazzarin E., Merlin S., Migliorini G., Pozzan T., Sarto L., Visona S., Brazzoli A., Campi A., Carmagnani R., Giambelli S., Gianella A., Lunardi L., Madaghiele D., Maestrelli P., Paiola L., Posteri E., Viola L., Zamberlan V., Zenari M., Zanoni M., Bonadonna G., Bonomo M., Santonastaso P., Cremonese C., Veronese A., Anderle P., Angelozzi A., Baron I. A. G., Candeago E. B. F., Castelli F., Chieco M., Di Costanzo E., Derossi M., Doriguzzi M., Galvano O., Lattanzi M., Lezzi R., Marcato M., Marcolin A., Marini F., Matranga M., Scalabrin D., Zucchetto M., Zadro F., Austoni G., Bianco M., Bordino F., Dario F., De Risio A., Gatto A., Grana S., Favero E., Franceschini A., Friederici S., Marangon V., Pascolo M., Ramon L., Zambolin S., Riolo R., Buffon A., Di Bortolo E., Fortin S., Matarrese F., Mogni S., Codemo N., Russi A., Silvestro A., Turella E., Viel P., Dominoni A., Andreose L., Boemio M., Bressan L., Cabbia A., Canesso E., Cian R., Dal Piccol C., Pasqua M. M. D., Di Prisco A., Mantellato L., Luison M., Morgante S., Santi M., Sacillotto M., Scabbio M., Sponga P., Sguotto M., Stach F., Vettorato M., Martinello G., Dassie F., Marino S., Cibiniel L., Masetto I., Cabianca O., Valente A., Caberlotto L., Passoni A., Flumian P., Daniel L., Gion M., Stanziale S., Alborino F., Bortolozzo V., Bacelle L., Bicciato L., Basso D., Navaglia F., Manoni F., Ercolin M., Giubilini F., Imbesi M., Leuci E., Mazzi F., Anelli S., Amore M., Bigi L., Britta W., Anna G. B., Bonatti U., Borziani M., Crosato S., Fabris I., Galluccio R., Galeotti M., Gozzi M., Greco V., Guagnini E., Pagani S., Maccherozzi S., Malvasi R., Marchi F., Melato E., Mazzucchi E., Marzullo F., Pellegrini P., Petrolini N., Volta P., Bonara F., Brusamonti E., Croci R., Flamia I., Fontana F., Losi R., Marchioro R., Raffaini L., Ruju L., Saginario A., Tondelli M., Marrama D., Bernardelli L., Bonacini F., Florindo A., Merli M., Nappo P., Sola L., Tondelli O., Tonna M., Torre M., Tosatti M., Venturelli G., Zampolla D., Bernardi A., Cavalli C., Cigala L., Ciraudo C., Di Bari A., Ferri L., Gombi F., Leurini S., Mandatelli E., Maccaferri S., Oroboncoide M., Pisa B., Ricci C., Poggi E., Zurlini C., Malpeli M., Colla R., Teodori E., Vecchia L., D'Andrea R., Trenti T., Paolini P., Carpeggiani P., Ghigi D., Gagliostro M., Pratelli M., Antonelli A., Battistini L., Bellini F., Bonini E., Capelli C. B. R., DiDomizio C., Drei C., Fucci G., Gualandi A., Grazia M. R., Losi A. M., Mazzoni F. M. P., Marangoni D., Monna G., Morselli M., Oggioni A., Oprandi S., Paganelli W., Passerini M., Piscitelli M., Reggiani G., Rossi G., Salvatori F., Trasforini S., Uslenghi C., Veggetti S., Bartolucci G., Baruffa R., Bertelli R., Borghi L., Ciavarella P., Paltrinieri E., Rizzardi F., Serra P., Suzzi D., Arienti P., Aureli F., Avanzi R., Callegari V., Corsino A., Host P., Michetti R., Rizzo F., Simoncelli P., Soldati E., Succi E., Bertozzi M., Canetti E., Cavicchioli L., Ceccarelli E., Cenni S., Marzola G., Gallina V., Leoni C., Olivieri A., Piccolo E., Ravagli S., Russo R., Tedeschini D., Verenini M., Abram W., Granata V., Curcio A., Guerra G., Granini S., Natali L., Montanari E., Pasi F., Ventura U., Valenti S., Francesca M., Farneti R., Ravagli P., Floris R., Maroncelli O., Volpones G., Casali D., Miceli M., Bencini A., Cellini M., De Biase L., Barbara L., Charles L., Pratesi C., Tanini A., Loparrino R., Ulivelli C., Cussoto C., Dei N., Fumanti E., Pantani M., Zeloni G., Bellini R., Cellesi R., Dorigo N., Gulli P., Ialeggio L., Pisanu M., Rinaldi G., Konze A., Cocchi A., Meneghelli A., Frova M., Monzani E., Zanobio A., Malagoli M., Pagani R., Barbera S., Morganti C., Amade E. S., Brambilla V., Montanari A., Caterina G., Lopez C., Marocchi A., Moletta A., Sberna M., Cascio M. T., Scarone S., Gargano, G, Caletti, E, Perlini, C, Turtulici, N, Bellani, M, Bonivento, C, Garzitto, M, Siri, F, Longo, C, Bonetto, C, Cristofalo, D, Scocco, P, Semrov, E, Preti, A, Lazzarotto, L, Gardellin, F, Lasalvia, A, Ruggeri, M, Marini, A, Brambilla, P, Bertani, M, Bissoli, S, De Santi, K, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, M, Ballarin, M, De Girolamo, G, Fioritti, A, Neri, G, Pileggi, F, Rucci, P, Chiavetto, L, Scasselatti, C, Zanardini, R, Bertoldo, A, Marinelli, V, Rambaldelli, G, Bardella, S, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosi, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefani, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, C, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Aldi, F, Bianchi, B, Cappellari, P, Conti, R, De Battisti, L, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visona, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Santonastaso, P, Cremonese, C, Veronese, A, Anderle, P, Angelozzi, A, Baron, I, Candeago, E, Castelli, F, Chieco, M, Di Costanzo, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanzi, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, De Risio, A, Gatto, A, Grana, S, Favero, E, Franceschini, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Di Bortolo, E, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, Dominoni, A, Andreose, L, Boemio, M, Bressan, L, Cabbia, A, Canesso, E, Cian, R, Dal Piccol, C, Pasqua, M, Di Prisco, A, Mantellato, L, Luison, M, Morgante, S, Santi, M, Sacillotto, M, Scabbio, M, Sponga, P, Sguotto, M, Stach, F, Vettorato, M, Martinello, G, Dassie, F, Marino, S, Cibiniel, L, Masetto, I, Cabianca, O, Valente, A, Caberlotto, L, Passoni, A, Flumian, P, Daniel, L, Gion, M, Stanziale, S, Alborino, F, Bortolozzo, V, Bacelle, L, Bicciato, L, Basso, D, Navaglia, F, Manoni, F, Ercolin, M, Giubilini, F, Imbesi, M, Leuci, E, Mazzi, F, Anelli, S, Amore, M, Bigi, L, Britta, W, Anna, G, Bonatti, U, Borziani, M, Crosato, S, Fabris, I, Galluccio, R, Galeotti, M, Gozzi, M, Greco, V, Guagnini, E, Pagani, S, Maccherozzi, S, Malvasi, R, Marchi, F, Melato, E, Mazzucchi, E, Marzullo, F, Pellegrini, P, Petrolini, N, Volta, P, Bonara, F, Brusamonti, E, Croci, R, Flamia, I, Fontana, F, Losi, R, Marchioro, R, Raffaini, L, Ruju, L, Saginario, A, Tondelli, M, Marrama, D, Bernardelli, L, Bonacini, F, Florindo, A, Merli, M, Nappo, P, Sola, L, Tondelli, O, Tonna, M, Torre, M, Tosatti, M, Venturelli, G, Zampolla, D, Bernardi, A, Cavalli, C, Cigala, L, Ciraudo, C, Di Bari, A, Ferri, L, Gombi, F, Leurini, S, Mandatelli, E, Maccaferri, S, Oroboncoide, M, Pisa, B, Ricci, C, Poggi, E, Zurlini, C, Malpeli, M, Colla, R, Teodori, E, Vecchia, L, D'Andrea, R, Trenti, T, Paolini, P, Carpeggiani, P, Ghigi, D, Gagliostro, M, Pratelli, M, Antonelli, A, Battistini, L, Bellini, F, Bonini, E, Capelli, C, Didomizio, C, Drei, C, Fucci, G, Gualandi, A, Grazia, M, Losi, A, Mazzoni, F, Marangoni, D, Monna, G, Morselli, M, Oggioni, A, Oprandi, S, Paganelli, W, Passerini, M, Piscitelli, M, Reggiani, G, Rossi, G, Salvatori, F, Trasforini, S, Uslenghi, C, Veggetti, S, Bartolucci, G, Baruffa, R, Bertelli, R, Borghi, L, Ciavarella, P, Paltrinieri, E, Rizzardi, F, Serra, P, Suzzi, D, Arienti, P, Aureli, F, Avanzi, R, Callegari, V, Corsino, A, Host, P, Michetti, R, Rizzo, F, Simoncelli, P, Soldati, E, Succi, E, Bertozzi, M, Canetti, E, Cavicchioli, L, Ceccarelli, E, Cenni, S, Marzola, G, Gallina, V, Leoni, C, Olivieri, A, Piccolo, E, Ravagli, S, Russo, R, Tedeschini, D, Verenini, M, Abram, W, Granata, V, Curcio, A, Guerra, G, Granini, S, Natali, L, Montanari, E, Pasi, F, Ventura, U, Valenti, S, Francesca, M, Farneti, R, Ravagli, P, Floris, R, Maroncelli, O, Volpones, G, Casali, D, Miceli, M, Bencini, A, Cellini, M, De Biase, L, Barbara, L, Charles, L, Pratesi, C, Tanini, A, Loparrino, R, Ulivelli, C, Cussoto, C, Dei, N, Fumanti, E, Pantani, M, Zeloni, G, Bellini, R, Cellesi, R, Dorigo, N, Gulli, P, Ialeggio, L, Pisanu, M, Rinaldi, G, Konze, A, Cocchi, A, Meneghelli, A, Frova, M, Monzani, E, Zanobio, A, Malagoli, M, Pagani, R, Barbera, S, Morganti, C, Amade, E, Brambilla, V, Montanari, A, Caterina, G, Lopez, C, Marocchi, A, Moletta, A, Sberna, M, Cascio, M, Scarone, S, Gargano G., Caletti E., Perlini C., Turtulici N., Bellani M., Bonivento C., Garzitto M., Siri F. M., Longo C., Bonetto C., Cristofalo D., Scocco P., Semrov E., Preti A., Lazzarotto L., Gardellin F., Lasalvia A., Ruggeri M., Marini A., Brambilla P., Bertani M. E., Bissoli S., De Santi K., Lunardi S., Negretto V., Poli S., Tosato S., Zamboni M. G., Ballarin M., De Girolamo G., Fioritti A., Neri G., Pileggi F., Rucci P., Chiavetto L. B., Scasselatti C., Zanardini R., Bertoldo A., Marinelli V., Rambaldelli G., Bardella S., Lamonaca D., Lunardon M., Magnabosco R., Martucci M., Nicolau S., Nifosi F., Pavanati M., Rossi M., Piazza C., Piccione G., Sala A., Sale A., Stefani B., Zotos S., Balbo M., Boggian I., Ceccato E., Dall'Agnola R., Girotto B., Goss C., Leoni R., Mai A., Pasqualini A., Roccato S., Rossi A., Strizzolo S., Urbani A., Aldi F., Bianchi B., Cappellari P., Conti R., De Battisti L., Lazzarin E., Merlin S., Migliorini G., Pozzan T., Sarto L., Visona S., Brazzoli A., Campi A., Carmagnani R., Giambelli S., Gianella A., Lunardi L., Madaghiele D., Maestrelli P., Paiola L., Posteri E., Viola L., Zamberlan V., Zenari M., Zanoni M., Bonadonna G., Bonomo M., Santonastaso P., Cremonese C., Veronese A., Anderle P., Angelozzi A., Baron I. A. G., Candeago E. B. F., Castelli F., Chieco M., Di Costanzo E., Derossi M., Doriguzzi M., Galvano O., Lattanzi M., Lezzi R., Marcato M., Marcolin A., Marini F., Matranga M., Scalabrin D., Zucchetto M., Zadro F., Austoni G., Bianco M., Bordino F., Dario F., De Risio A., Gatto A., Grana S., Favero E., Franceschini A., Friederici S., Marangon V., Pascolo M., Ramon L., Zambolin S., Riolo R., Buffon A., Di Bortolo E., Fortin S., Matarrese F., Mogni S., Codemo N., Russi A., Silvestro A., Turella E., Viel P., Dominoni A., Andreose L., Boemio M., Bressan L., Cabbia A., Canesso E., Cian R., Dal Piccol C., Pasqua M. M. D., Di Prisco A., Mantellato L., Luison M., Morgante S., Santi M., Sacillotto M., Scabbio M., Sponga P., Sguotto M., Stach F., Vettorato M., Martinello G., Dassie F., Marino S., Cibiniel L., Masetto I., Cabianca O., Valente A., Caberlotto L., Passoni A., Flumian P., Daniel L., Gion M., Stanziale S., Alborino F., Bortolozzo V., Bacelle L., Bicciato L., Basso D., Navaglia F., Manoni F., Ercolin M., Giubilini F., Imbesi M., Leuci E., Mazzi F., Anelli S., Amore M., Bigi L., Britta W., Anna G. B., Bonatti U., Borziani M., Crosato S., Fabris I., Galluccio R., Galeotti M., Gozzi M., Greco V., Guagnini E., Pagani S., Maccherozzi S., Malvasi R., Marchi F., Melato E., Mazzucchi E., Marzullo F., Pellegrini P., Petrolini N., Volta P., Bonara F., Brusamonti E., Croci R., Flamia I., Fontana F., Losi R., Marchioro R., Raffaini L., Ruju L., Saginario A., Tondelli M., Marrama D., Bernardelli L., Bonacini F., Florindo A., Merli M., Nappo P., Sola L., Tondelli O., Tonna M., Torre M., Tosatti M., Venturelli G., Zampolla D., Bernardi A., Cavalli C., Cigala L., Ciraudo C., Di Bari A., Ferri L., Gombi F., Leurini S., Mandatelli E., Maccaferri S., Oroboncoide M., Pisa B., Ricci C., Poggi E., Zurlini C., Malpeli M., Colla R., Teodori E., Vecchia L., D'Andrea R., Trenti T., Paolini P., Carpeggiani P., Ghigi D., Gagliostro M., Pratelli M., Antonelli A., Battistini L., Bellini F., Bonini E., Capelli C. B. R., DiDomizio C., Drei C., Fucci G., Gualandi A., Grazia M. R., Losi A. M., Mazzoni F. M. P., Marangoni D., Monna G., Morselli M., Oggioni A., Oprandi S., Paganelli W., Passerini M., Piscitelli M., Reggiani G., Rossi G., Salvatori F., Trasforini S., Uslenghi C., Veggetti S., Bartolucci G., Baruffa R., Bertelli R., Borghi L., Ciavarella P., Paltrinieri E., Rizzardi F., Serra P., Suzzi D., Arienti P., Aureli F., Avanzi R., Callegari V., Corsino A., Host P., Michetti R., Rizzo F., Simoncelli P., Soldati E., Succi E., Bertozzi M., Canetti E., Cavicchioli L., Ceccarelli E., Cenni S., Marzola G., Gallina V., Leoni C., Olivieri A., Piccolo E., Ravagli S., Russo R., Tedeschini D., Verenini M., Abram W., Granata V., Curcio A., Guerra G., Granini S., Natali L., Montanari E., Pasi F., Ventura U., Valenti S., Francesca M., Farneti R., Ravagli P., Floris R., Maroncelli O., Volpones G., Casali D., Miceli M., Bencini A., Cellini M., De Biase L., Barbara L., Charles L., Pratesi C., Tanini A., Loparrino R., Ulivelli C., Cussoto C., Dei N., Fumanti E., Pantani M., Zeloni G., Bellini R., Cellesi R., Dorigo N., Gulli P., Ialeggio L., Pisanu M., Rinaldi G., Konze A., Cocchi A., Meneghelli A., Frova M., Monzani E., Zanobio A., Malagoli M., Pagani R., Barbera S., Morganti C., Amade E. S., Brambilla V., Montanari A., Caterina G., Lopez C., Marocchi A., Moletta A., Sberna M., Cascio M. T., and Scarone S.
- Abstract
Language production has often been described as impaired in psychiatric diseases such as in psychosis. Nevertheless, little is known about the characteristics of linguistic difficulties and their relation with other cognitive domains in patients with a first episode of psychosis (FEP), either affective or non-affective. To deepen our comprehension of linguistic profile in FEP, 133 patients with FEP (95 non-affective, FEP-NA; 38 affective, FEP-A) and 133 healthy controls (HC) were assessed with a narrative discourse task. Speech samples were systematically analyzed with a well-established multilevel procedure investigating both micro- (lexicon, morphology, syntax) and macro-linguistic (discourse coherence, pragmatics) levels of linguistic processing. Executive functioning and IQ were also evaluated. Both linguistic and neuropsychological measures were secondarily implemented with a machine learning approach in order to explore their predictive accuracy in classifying participants as FEP or HC. Compared to HC, FEP patients showed language production difficulty at both micro- and macro-linguistic levels. As for the former, FEP produced shorter and simpler sentences and fewer words per minute, along with a reduced number of lexical fillers, compared to HC. At the macro-linguistic level, FEP performance was impaired in local coherence, which was paired with a higher percentage of utterances with semantic errors. Linguistic measures were not correlated with any neuropsychological variables. No significant differences emerged between FEP-NA and FEP-A (p≥0.02, after Bonferroni correction). Machine learning analysis showed an accuracy of group prediction of 76.36% using language features only, with semantic variables being the most impactful. Such a percentage was enhanced when paired with clinical and neuropsychological variables. Results confirm the presence of language production deficits already at the first episode of the illness, being such impairment not related to ot
- Published
- 2022
3. Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ
- Author
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Noto, A, De Vitis, C, Pisanu, M E, Roscilli, G, Ricci, G, Catizone, A, Sorrentino, G, Chianese, G, Taglialatela-Scafati, O, Trisciuoglio, D, Del Bufalo, D, Di Martile, M, Di Napoli, A, Ruco, L, Costantini, S, Jakopin, Z, Budillon, A, Melino, G, Del Sal, G, Ciliberto, G, and Mancini, R
- Published
- 2017
- Full Text
- View/download PDF
4. Language production impairments in patients with a first episode of psychosis
- Author
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Gargano G., Caletti E., Perlini C., Turtulici N., Bellani M., Bonivento C., Garzitto M., Siri F. M., Longo C., Bonetto C., Cristofalo D., Scocco P., Semrov E., Preti A., Lazzarotto L., Gardellin F., Lasalvia A., Ruggeri M., Marini A., Brambilla P., Bertani M. E., Bissoli S., De Santi K., Lunardi S., Negretto V., Poli S., Tosato S., Zamboni M. G., Ballarin M., De Girolamo G., Fioritti A., Neri G., Pileggi F., Rucci P., Chiavetto L. B., Scasselatti C., Zanardini R., Bertoldo A., Marinelli V., Rambaldelli G., Bardella S., Lamonaca D., Lunardon M., Magnabosco R., Martucci M., Nicolau S., Nifosi F., Pavanati M., Rossi M., Piazza C., Piccione G., Sala A., Sale A., Stefani B., Zotos S., Balbo M., Boggian I., Ceccato E., Dall'Agnola R., Girotto B., Goss C., Leoni R., Mai A., Pasqualini A., Roccato S., Rossi A., Strizzolo S., Urbani A., Aldi F., Bianchi B., Cappellari P., Conti R., De Battisti L., Lazzarin E., Merlin S., Migliorini G., Pozzan T., Sarto L., Visona S., Brazzoli A., Campi A., Carmagnani R., Giambelli S., Gianella A., Lunardi L., Madaghiele D., Maestrelli P., Paiola L., Posteri E., Viola L., Zamberlan V., Zenari M., Zanoni M., Bonadonna G., Bonomo M., Santonastaso P., Cremonese C., Veronese A., Anderle P., Angelozzi A., Baron I. A. G., Candeago E. B. F., Castelli F., Chieco M., Di Costanzo E., Derossi M., Doriguzzi M., Galvano O., Lattanzi M., Lezzi R., Marcato M., Marcolin A., Marini F., Matranga M., Scalabrin D., Zucchetto M., Zadro F., Austoni G., Bianco M., Bordino F., Dario F., De Risio A., Gatto A., Grana S., Favero E., Franceschini A., Friederici S., Marangon V., Pascolo M., Ramon L., Zambolin S., Riolo R., Buffon A., Di Bortolo E., Fortin S., Matarrese F., Mogni S., Codemo N., Russi A., Silvestro A., Turella E., Viel P., Dominoni A., Andreose L., Boemio M., Bressan L., Cabbia A., Canesso E., Cian R., Dal Piccol C., Pasqua M. M. D., Di Prisco A., Mantellato L., Luison M., Morgante S., Santi M., Sacillotto M., Scabbio M., Sponga P., Sguotto M., Stach F., Vettorato M., Martinello G., Dassie F., Marino S., Cibiniel L., Masetto I., Cabianca O., Valente A., Caberlotto L., Passoni A., Flumian P., Daniel L., Gion M., Stanziale S., Alborino F., Bortolozzo V., Bacelle L., Bicciato L., Basso D., Navaglia F., Manoni F., Ercolin M., Giubilini F., Imbesi M., Leuci E., Mazzi F., Anelli S., Amore M., Bigi L., Britta W., Anna G. B., Bonatti U., Borziani M., Crosato S., Fabris I., Galluccio R., Galeotti M., Gozzi M., Greco V., Guagnini E., Pagani S., Maccherozzi S., Malvasi R., Marchi F., Melato E., Mazzucchi E., Marzullo F., Pellegrini P., Petrolini N., Volta P., Bonara F., Brusamonti E., Croci R., Flamia I., Fontana F., Losi R., Marchioro R., Raffaini L., Ruju L., Saginario A., Tondelli M., Marrama D., Bernardelli L., Bonacini F., Florindo A., Merli M., Nappo P., Sola L., Tondelli O., Tonna M., Torre M., Tosatti M., Venturelli G., Zampolla D., Bernardi A., Cavalli C., Cigala L., Ciraudo C., Di Bari A., Ferri L., Gombi F., Leurini S., Mandatelli E., Maccaferri S., Oroboncoide M., Pisa B., Ricci C., Poggi E., Zurlini C., Malpeli M., Colla R., Teodori E., Vecchia L., D'Andrea R., Trenti T., Paolini P., Carpeggiani P., Ghigi D., Gagliostro M., Pratelli M., Antonelli A., Battistini L., Bellini F., Bonini E., Capelli C. B. R., DiDomizio C., Drei C., Fucci G., Gualandi A., Grazia M. R., Losi A. M., Mazzoni F. M. P., Marangoni D., Monna G., Morselli M., Oggioni A., Oprandi S., Paganelli W., Passerini M., Piscitelli M., Reggiani G., Rossi G., Salvatori F., Trasforini S., Uslenghi C., Veggetti S., Bartolucci G., Baruffa R., Bertelli R., Borghi L., Ciavarella P., Paltrinieri E., Rizzardi F., Serra P., Suzzi D., Arienti P., Aureli F., Avanzi R., Callegari V., Corsino A., Host P., Michetti R., Rizzo F., Simoncelli P., Soldati E., Succi E., Bertozzi M., Canetti E., Cavicchioli L., Ceccarelli E., Cenni S., Marzola G., Gallina V., Leoni C., Olivieri A., Piccolo E., Ravagli S., Russo R., Tedeschini D., Verenini M., Abram W., Granata V., Curcio A., Guerra G., Granini S., Natali L., Montanari E., Pasi F., Ventura U., Valenti S., Francesca M., Farneti R., Ravagli P., Floris R., Maroncelli O., Volpones G., Casali D., Miceli M., Bencini A., Cellini M., De Biase L., Barbara L., Charles L., Pratesi C., Tanini A., Loparrino R., Ulivelli C., Cussoto C., Dei N., Fumanti E., Pantani M., Zeloni G., Bellini R., Cellesi R., Dorigo N., Gulli P., Ialeggio L., Pisanu M., Rinaldi G., Konze A., Cocchi A., Meneghelli A., Frova M., Monzani E., Zanobio A., Malagoli M., Pagani R., Barbera S., Morganti C., Amade E. S., Brambilla V., Montanari A., Caterina G., Lopez C., Marocchi A., Moletta A., Sberna M., Cascio M. T., Scarone S., Gargano, G, Caletti, E, Perlini, C, Turtulici, N, Bellani, M, Bonivento, C, Garzitto, M, Siri, F, Longo, C, Bonetto, C, Cristofalo, D, Scocco, P, Semrov, E, Preti, A, Lazzarotto, L, Gardellin, F, Lasalvia, A, Ruggeri, M, Marini, A, Brambilla, P, Bertani, M, Bissoli, S, De Santi, K, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, M, Ballarin, M, De Girolamo, G, Fioritti, A, Neri, G, Pileggi, F, Rucci, P, Chiavetto, L, Scasselatti, C, Zanardini, R, Bertoldo, A, Marinelli, V, Rambaldelli, G, Bardella, S, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosi, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefani, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, C, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Aldi, F, Bianchi, B, Cappellari, P, Conti, R, De Battisti, L, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visona, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Santonastaso, P, Cremonese, C, Veronese, A, Anderle, P, Angelozzi, A, Baron, I, Candeago, E, Castelli, F, Chieco, M, Di Costanzo, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanzi, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, De Risio, A, Gatto, A, Grana, S, Favero, E, Franceschini, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Di Bortolo, E, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, Dominoni, A, Andreose, L, Boemio, M, Bressan, L, Cabbia, A, Canesso, E, Cian, R, Dal Piccol, C, Pasqua, M, Di Prisco, A, Mantellato, L, Luison, M, Morgante, S, Santi, M, Sacillotto, M, Scabbio, M, Sponga, P, Sguotto, M, Stach, F, Vettorato, M, Martinello, G, Dassie, F, Marino, S, Cibiniel, L, Masetto, I, Cabianca, O, Valente, A, Caberlotto, L, Passoni, A, Flumian, P, Daniel, L, Gion, M, Stanziale, S, Alborino, F, Bortolozzo, V, Bacelle, L, Bicciato, L, Basso, D, Navaglia, F, Manoni, F, Ercolin, M, Giubilini, F, Imbesi, M, Leuci, E, Mazzi, F, Anelli, S, Amore, M, Bigi, L, Britta, W, Anna, G, Bonatti, U, Borziani, M, Crosato, S, Fabris, I, Galluccio, R, Galeotti, M, Gozzi, M, Greco, V, Guagnini, E, Pagani, S, Maccherozzi, S, Malvasi, R, Marchi, F, Melato, E, Mazzucchi, E, Marzullo, F, Pellegrini, P, Petrolini, N, Volta, P, Bonara, F, Brusamonti, E, Croci, R, Flamia, I, Fontana, F, Losi, R, Marchioro, R, Raffaini, L, Ruju, L, Saginario, A, Tondelli, M, Marrama, D, Bernardelli, L, Bonacini, F, Florindo, A, Merli, M, Nappo, P, Sola, L, Tondelli, O, Tonna, M, Torre, M, Tosatti, M, Venturelli, G, Zampolla, D, Bernardi, A, Cavalli, C, Cigala, L, Ciraudo, C, Di Bari, A, Ferri, L, Gombi, F, Leurini, S, Mandatelli, E, Maccaferri, S, Oroboncoide, M, Pisa, B, Ricci, C, Poggi, E, Zurlini, C, Malpeli, M, Colla, R, Teodori, E, Vecchia, L, D'Andrea, R, Trenti, T, Paolini, P, Carpeggiani, P, Ghigi, D, Gagliostro, M, Pratelli, M, Antonelli, A, Battistini, L, Bellini, F, Bonini, E, Capelli, C, Didomizio, C, Drei, C, Fucci, G, Gualandi, A, Grazia, M, Losi, A, Mazzoni, F, Marangoni, D, Monna, G, Morselli, M, Oggioni, A, Oprandi, S, Paganelli, W, Passerini, M, Piscitelli, M, Reggiani, G, Rossi, G, Salvatori, F, Trasforini, S, Uslenghi, C, Veggetti, S, Bartolucci, G, Baruffa, R, Bertelli, R, Borghi, L, Ciavarella, P, Paltrinieri, E, Rizzardi, F, Serra, P, Suzzi, D, Arienti, P, Aureli, F, Avanzi, R, Callegari, V, Corsino, A, Host, P, Michetti, R, Rizzo, F, Simoncelli, P, Soldati, E, Succi, E, Bertozzi, M, Canetti, E, Cavicchioli, L, Ceccarelli, E, Cenni, S, Marzola, G, Gallina, V, Leoni, C, Olivieri, A, Piccolo, E, Ravagli, S, Russo, R, Tedeschini, D, Verenini, M, Abram, W, Granata, V, Curcio, A, Guerra, G, Granini, S, Natali, L, Montanari, E, Pasi, F, Ventura, U, Valenti, S, Francesca, M, Farneti, R, Ravagli, P, Floris, R, Maroncelli, O, Volpones, G, Casali, D, Miceli, M, Bencini, A, Cellini, M, De Biase, L, Barbara, L, Charles, L, Pratesi, C, Tanini, A, Loparrino, R, Ulivelli, C, Cussoto, C, Dei, N, Fumanti, E, Pantani, M, Zeloni, G, Bellini, R, Cellesi, R, Dorigo, N, Gulli, P, Ialeggio, L, Pisanu, M, Rinaldi, G, Konze, A, Cocchi, A, Meneghelli, A, Frova, M, Monzani, E, Zanobio, A, Malagoli, M, Pagani, R, Barbera, S, Morganti, C, Amade, E, Brambilla, V, Montanari, A, Caterina, G, Lopez, C, Marocchi, A, Moletta, A, Sberna, M, Cascio, M, and Scarone, S
- Subjects
Language Disorders ,Multidisciplinary ,Comprehension ,Humans ,Language ,Neuropsychological Tests ,Psychotic Disorders ,Psychosis ,Language Disorder ,Psychosis, Language, Cognition, Neuropsychology ,Cognition ,Neuropsychology ,Neuropsychological Test ,Settore MED/25 - Psichiatria ,Human - Abstract
Language production has often been described as impaired in psychiatric diseases such as in psychosis. Nevertheless, little is known about the characteristics of linguistic difficulties and their relation with other cognitive domains in patients with a first episode of psychosis (FEP), either affective or non-affective. To deepen our comprehension of linguistic profile in FEP, 133 patients with FEP (95 non-affective, FEP-NA; 38 affective, FEP-A) and 133 healthy controls (HC) were assessed with a narrative discourse task. Speech samples were systematically analyzed with a well-established multilevel procedure investigating both micro- (lexicon, morphology, syntax) and macro-linguistic (discourse coherence, pragmatics) levels of linguistic processing. Executive functioning and IQ were also evaluated. Both linguistic and neuropsychological measures were secondarily implemented with a machine learning approach in order to explore their predictive accuracy in classifying participants as FEP or HC. Compared to HC, FEP patients showed language production difficulty at both micro- and macro-linguistic levels. As for the former, FEP produced shorter and simpler sentences and fewer words per minute, along with a reduced number of lexical fillers, compared to HC. At the macro-linguistic level, FEP performance was impaired in local coherence, which was paired with a higher percentage of utterances with semantic errors. Linguistic measures were not correlated with any neuropsychological variables. No significant differences emerged between FEP-NA and FEP-A (p≥0.02, after Bonferroni correction). Machine learning analysis showed an accuracy of group prediction of 76.36% using language features only, with semantic variables being the most impactful. Such a percentage was enhanced when paired with clinical and neuropsychological variables. Results confirm the presence of language production deficits already at the first episode of the illness, being such impairment not related to other cognitive domains. The high accuracy obtained by the linguistic set of features in classifying groups support the use of machine learning methods in neuroscience investigations.
- Published
- 2022
5. Asymptomatic and symptomatic deep venous thrombosis in hospitalized acutely ill medical patients. risk factors and therapeutic implications
- Author
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Loffredo L., Vidili G., Sciacqua A., Cogliati C., Di Giulio R., Bernardini S., Ciacci P., Pietrangelo A., Orlando F., Paraninfi A., Boddi M., Di Minno G., Falsetti L., Lodigiani C., Santoliquido A., Ettorre E., Pignatelli P., Arezzo M. F., Gutu E., Harenberg J., Violi F., Casciaro M. A., Morelli S., Accapezzato D., Rossi E., Palumbo I. M., Pannunzio A., Fallarino A., Maggio E., Bocchini V. P., Gioia C., Izzo R., Luongo R., Cosenza M., Bisciglia M. F., Battaglia S., Pirillo L. S., Capozza A., Summa M. L., Armentaro G., Volpentesta M., Rullo R., Baldinia L., Arienti V., Meloni P. L., Sauchella A., Melis S., Berria M., Solinas B., Vilardi L., Sarobba P., Pisanu M., Mangatia P., Cringoli M., Blanca D., Casella F., Vegetti A., Crociani A., Donnarumma E., Pacciani G., Rovereto R., Lunardi S., Tufano A., Pacetti V., Domenicali M., Leopoldo P., Ceci F., Loffredo, L., Vidili, G., Sciacqua, A., Cogliati, C., Di Giulio, R., Bernardini, S., Ciacci, P., Pietrangelo, A., Orlando, F., Paraninfi, A., Boddi, M., Di Minno, G., Falsetti, L., Lodigiani, C., Santoliquido, A., Ettorre, E., Pignatelli, P., Arezzo, M. F., Gutu, E., Harenberg, J., Violi, F., Casciaro, M. A., Morelli, S., Accapezzato, D., Rossi, E., Palumbo, I. M., Pannunzio, A., Fallarino, A., Maggio, E., Bocchini, V. P., Gioia, C., Izzo, R., Luongo, R., Cosenza, M., Bisciglia, M. F., Battaglia, S., Pirillo, L. S., Capozza, A., Summa, M. L., Armentaro, G., Volpentesta, M., Rullo, R., Baldinia, L., Arienti, V., Meloni, P. L., Sauchella, A., Melis, S., Berria, M., Solinas, B., Vilardi, L., Sarobba, P., Pisanu, M., Mangatia, P., Cringoli, M., Blanca, D., Casella, F., Vegetti, A., Crociani, A., Donnarumma, E., Pacciani, G., Rovereto, R., Lunardi, S., Tufano, A., Pacetti, V., Domenicali, M., Leopoldo, P., and Ceci, F.
- Subjects
anticoagulants ,asymptomatic deep venous thrombosis ,compression ultrasound ,Anticoagulant ,medical patient ,Hematology ,Asymptomatic deep venous thrombosi ,Deep venous thrombosi ,deep venous thrombosis - Abstract
Background Acutely ill medical patients experience deep venous thrombosis (DVT) during the hospitalization, however the time course of DVT is still unclear. Objectives To evaluate risk factors in acutely ill hospitalized medical patients for proximal asymptomatic DVT (ADVT) and symptomatic DVT (SDVT) at admission and discharge. Patients/Methods In this prospective observational study, consecutive acutely ill medical patients (hospitalized mainly for acute medical disease as infections, neoplasm, anemia, heart failure) underwent compression ultrasonography (CUS) of proximal lower limb veins within 48 h from admission and at discharge to diagnose ADVT and SDVT. Covid-19 patients, anticoagulant therapy, surgical procedures, acute SDVT, and acute pulmonary embolism, were exclusion criteria. Biographical characteristics at hospitalization, D-Dimer (assessed by ELISA)) and DD-improve score. Results Of 2,100 patients (1002 females, 998 males, age 71 ± 16 years) 58 (2.7%) had proximal ADVT at admission. Logistic regression analysis showed that age, and active cancer were independently associated with ADVT at admission. The median length of hospitalization was 10 days [interquartile range: 6–15]. During the hospital stay, 6 patients (0.3%) with a negative CUS at admission experienced DVT (2 SDVT and 4 ADVT). In the subgroup of patients (n = 1118), in whom D-dimer was measured at admission, D-Dimer and IMPROVE-DD score were associated with ADVT at admission (n = 37) and with all DVT (n = 42) at discharge. ROC curve defined an IMPROVE-DD score of 2.5 as the optimal cut-off for discriminating patients with and without thrombotic events. Conclusions We provide evidence of early development of ADVT in unselected acutely ill medical patients suggesting the need of investigating patients by CUS immediately after hospital admission (within 48 h). Advanced age, active cancer, known thrombophilia and increased IMPROVE-DD score may identify patients at risk. The benefit of anticoagulation needs to be investigated in patients with these specific risk factors and negative CUS at admission. Trial registration NCT03157843.
- Published
- 2022
6. Erratum: Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ
- Author
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Noto, A, De Vitis, C, Pisanu, M E, Roscilli, G, Ricci, G, Catizone, A, Sorrentino, G, Chianese, G, Taglialatela-Scafati, O, Trisciuoglio, D, Del Bufalo, D, Di Martile, M, Di Napoli, A, Ruco, L, Costantini, S, Jakopin, Z, Budillon, A, Melino, G, Del Sal, G, Ciliberto, G, and Mancini, R
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- 2017
- Full Text
- View/download PDF
7. Elective cancer surgery in COVID-19–Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study
- Author
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James C Glasbey, Dmitri Nepogodiev, Joana Ff Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Mohammad Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganyli, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham Ma Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar, Raghavan Vidya, Aneel A Bhangu, James C Glasbey, Omar Omar, Aneel A Bhangu, Kwabena Siaw-Acheampong, Ruth A Benson, Edward Bywater, Daoud Chaudhry, Brett E Dawson, Jonathan P Evans, James C Glasbey, Rohan R Gujjuri, Emily Heritage, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew Knight, Samuel Lawday, Elizabeth Li, Harvinder S Mann, Ella J Marson, Kenneth A McLean, Siobhan C McKay, Emily C Mills, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana Ff Simoes, Isobel M Trout, Mary L Venn, Richard Jw Wilkin, Aneel A Bhangu, James C Glasbey, Neil J Smart, Ana Minaya-Bravo, Jonathan P Evans, Gaetano Gallo, Susan Moug, Francesco Pata, Peter Pockney, Salomone Di Saverio, Abigail Vallance, Dale Vimalchandran, Ewen A Griffiths, Sivesh K Kamarajah, Richard Pt Evans, Philip Townend, Keith Roberts, Siobhan McKay, John Isaac, Sohei Satoi, John Edwards, Aman S Coonar, Adrian Marchbank, Edward J Caruana, Georgia R Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J Price, Daniel M Fountain, Michael D Jenkinson, Peter Hutchinson, Hani J Marcus, Rory J Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G Schache, Stuart C Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T S Shylasree, R Kottayasamy Seenivasagam, Joe Ng, Keiiji Fujiwara, Grant D Stewart, Benjamin Lamb, Krishna Narahari, Alan McNeill, Alexandra Colquhoun, John McGrath, Steve Bromage, Ravi Barod, Veeru Kasivisvanathan, Tobias Klatte, Joana Ff Simoes, Tom Ef Abbott, Sadi Abukhalaf, Michel Adamina, Adesoji O Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeiers, Osaid Alser, Muhammad Alshaar, Sattar Alshryda, Alexis P Arnaud, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany K Bankhead-Kendall, Emma Barlow, David Beard, Ruth A Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A Breen, Chris Bretherton, Igor Lima Buarque, Joshua Burke, Edward J Caruana, Mohammad Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moises Cukier, Miguel F Cunha, Giana H Davidson, Anant Desai, Salomone Di Saverio, Thomas M Drake, John G Edwards, Muhammed Elhadi, Sameh Emile, Shebani Farik, Marco Fiore, J Edward Fitzgerald, Samuel Ford, Tatiana Garmanova, Gaetano Gallo, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A Griffiths, Madalegna GrÜndl, Constantine Halkias, Ewen M Harrison, Intisar Hisham, Peter J Hutchinson, Shelley Hwang, Arda Isik, Michael D Jenkinson, Pascal Jonker, Haytham Ma Kaafarani, Debby Keller, Angelos Kolias, Schelto Kruijff, Ismail Lawani, Hans Lederhuber, Sezai Leventoglu, Andrey Litvin, Andrew Loehrer, Markus W Löffler, Maria Aguilera Lorena, Maria Marta Modolo, Piotr Major, Janet Martin, Hassan N Mashbari, Dennis Mazingi, Symeon Metallidis, Ana Minaya-Bravo, Helen M Mohan, Rachel Moore, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, 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McNaught, R Alam, A Budacan, J Cahill, M Kalkat, S Karandikar, L Kenyon, D Naumann, A Patel, J Ayorinde, T Chase, T Cuming, A Ghanbari, L Humphreys, S Tayeh, A Aboelkassem Ibrahim, R Bichoo, H Cao, Akw Chai, J Choudhury, C Evans, H Fitzjohn, H Ikram, M Langstroth, M Loubani, A McMillan, S Nazir, Ssa Qadri, A Robinson, E Ross, T Sehgal, A Wilkins, J Dixon, J Dunning, K Freystaetter, M Jha, S Lester, A Madhavan, S V Thulasiraman, Y Viswanath, T Curl-Roper, C Delimpalta, Ccl Liao, V Velchuru, E Westwood, E Belcher, G Bond-Smith, S Chidambaram, F Di Chiara, K Fasanmade, L Fraser, H Fu, M Ganau, S Gore, J Graystone, D Jeyaretna, H Khatkar, M Lami, M Maher, S Mastoridis, R Mihai, R Piper, S Prabhu, Obf Risk, U Selbong, K Shah, R Smillie, H Soleymani Majd, S Sravanam, D Stavroulias, G D Tebala, M Vatish, C Verberne, K Wallwork, S Winter, M I Bhatti, H Boyd-Carson, E Elsey, E Gemmill, P Herrod, M Jibreel, E Lenzi, T Saafan, D Sapre, T Sian, N Watson, A Athanasiou, G Bourke, L Bradshaw, A Brunelli, J Burke, P Coe, F Costigan, H Elkadi, M Ho, J Johnstone, A Kanatas, V Kantola, A Kaufmann, A Laios, S Lam, E MacInnes, S Munot, C Nahm, M Otify, C Pompili, I Smith, G Theophilou, G Toogood, R Wade, D Ward, C West, S Annamalai, C Ashmore, A Boddy, T Hossain, A Kourdouli, A Gvaramadze, A Jibril, L Prusty, D Thekkinkattil, A Harky, M Shackcloth, A Askari, C Chan, N Cirocchi, S Kudchadkar, K Patel, J Sagar, S Shaw, R Talwar, M Abdalla, R Edmondson, O Ismail, D Jones, K Newton, N Stylianides, A Aderombi, U Andaleeb, O Bajomo, K Beatson, W Garrett, M Mehmood, V Ng, R Al-Habsi, G S Divya, B Keeler, B Al-Sarireh, R Egan, R Harries, A Henry, M Kittur, Z Li, K Parkins, F Soliman, N Spencer, D Thompson, C Burgess, C Gemmell, C Grieco, M Hollyman, L Hunt, J Morrison, S Ojha, N Ryan, F Abbadessa, S Barnard, C Chan, N Dawe, J Hammond, Ali F Mahmoud, I McPherson, C Mellor, J Moir, S Pandanaboyana, J Powell, B Rai, A Rogers, C Roy, A Sachdeva, C Saleh, S Tingle, T Williams, J Manickavasagam, C McDonald, N McGrath, N McSorley, K Ragupathy, L Ramsay, A Solth, O Kakisi, K Seebah, I Shaikh, L Sreedharan, M Youssef, J Shah, P Ameerally, N McLarty, S Mills, A Shenfine, K Sahnan, J Abu, E Addae-Boateng, D Bratt, L Brock, N Burnside, S Cadwell-Sneath, K Gajjar, C Gan, C Grundy, K Hallam, K Hassell, M Hawari, A Joshi, H Khout, K Konstantinidi, Rxn Lee, D Nunns, R Schiemer, T Walton, H Weaver, L Whisker, K Williamson, J McVeigh, R Myatt, M A Williams, R Kaur, E Leung, S Sundar, M Michel, S Patil, S Ravindran, J Sarveswaran, L Scott, M Edmond, E King, M Almond, A Bhangu, O Breik, L D Cato, A Desai, S Ford, E Griffiths, M Idle, M Kamal, A Kisiel, R Kulkarni, Jkc Mak, T Martin, P Nankivell, A Parente, S Parmar, A M Pathanki, L Phelan, P Praveen, S Saeed, N Sharma, J Singh, F Tirotta, D Vijayan, A Geddes, J McCaul, J McMahon, A H Khan, F Khan, A Mansuri, S Mukherjee, M Patel, M Sarigul, S Singh, K L Tan, A Woodham, A Adiamah, H Brewer, A Chowdhury, J Evans, D Humes, J Jackman, A Koh, C Lewis-Lloyd, O Oyende, J Reilly, D Worku, P Cool, G Cribb, K Shepherd, C Bisset, S Moug, N Elson, G Faulkner, P Saleh, C Underwood, G Brixton, L Findlay, T Klatte, A Majkowska, J Manson, R Potter, A Bhalla, Z Chia, P Daliya, A Goyal, E Grimley, A Hamad, A Kumar, F L Malcolm, E Theophilidou, J Bowden, N Campain, I Daniels, C Evans, G Fowler, J John, L Massey, F McDermott, J McGrath, A McLennan, M Ng, J Pascoe, N Rajaretnam, S Bulathsinhala, B Davidson, G Fusai, C Hidalgo Salinas, N Machairas, T Pissanou, J M Pollok, D A Raptis, F Soggiu, H Tzerbinis, S E Xyda, A Beamish, E Davies, R Foulkes, D Magowan, H Nassa, R Ooi, C Price, L Smith, F Solari, A Tang, G Williams, Y Al-Tamimi, A Bacon, N Beasley, D Chew, M Crank, N Ilenkovan, M Macdonald, B Narice, O Rominiyi, A Thompson, I Varley, T Drake, E Harrison, G Linder, J Mayes, R McGregor, R Skipworth, V Zamvar, E Davies, P Hawkin, T Raymond, O Ryska, R Baron, D Dunne, S Gahunia, C Halloran, N Howes, R McKinney, F McNicol, J Russ, P Szatmary, J R Tan, A Thomas, P Whelan, A Anzak, A Banerjee, O Fuwa, F Hughes, J D Jayasinghe, C Knowles, H Kocher, I Leal Silva, F S Ledesma, A Minicozzi, L Navaratne, R Rahman, R Ramamoorthy, C Sohrabi, M Thaha, B Thakur, M Venn, V Yip, R Baumber, J Parry, S Evans, L Jeys, G Morris, M Parry, J Stevenson, N Ahmadi, G Aresu, Z M Barrett-Brown, A S Coonar, H Durio Yates, D Gearon, J Hogan, M King, A Peryt, I S Pradeep, C Smith, M Adishesh, R Atherton, K Baxter, M Brocklehurst, M Chaudhury, N Krishnamohan, J McAleer, G Owens, E Parkin, P Patkar, I Phang, A Aladeojebi, M Ali, B Barmayehvar, A Gaunt, M Gowda, E Halliday, M Kitchen, F Mansour, M Thomas, D Zakai, N Abbassi-Ghadi, H Assalaarachchi, A Currie, M Flavin, A Frampton, M Hague, C Hammer, J Hopper, J Horsnell, S Humphries, A Kamocka, T K Madhuri, S Preston, P Singh, J Stebbing, A Tailor, D Walker, F Aljanadi, M Jones, P Mhandu, C O'Donnell, R Turkington, Z Al-Ishaq, S Bhasin, A S Bodla, A Burahee, A Crichton, R Fossett, N Pigadas, S Pickford, E Rahman, D Snee, R Vidya, N Yassin, F Colombo, D Fountain, M T Hasan, K Karabatsou, R Laurente, O Pathmanaban, A Al-Mukhtar, S Brown, J Edwards, A Giblin, C Kelty, M Lee, G Lye, T Newman, A Sharkey, C Steele, N Sureshkumar Shah, E Whitehall, R Athwal, A Baker, L Jones, C Konstantinou, S Ramcharan, S Singh, J Vatish, R Wilkin, M Ethunandan, G K Sekhon, H Shields, R Singh, F Wensley, S Lawday, A Lyons, T Abbott, S Anwar, K Ghufoor, C Sohrabi, E Chung, R Hagger, A Hainsworth, A Karim, H Owen, A Ramwell, K Williams, C Baker, A Davies, J Gossage, M Kelly, W Knight, J Hall, G Harris, G James, C Kang, D J Lin, A D Rajgor, T Royle, R Scurrah, B Steel, L J Watson, D Choi, R Hutchison, A Jain, V Luoma, H Marcus, R May, A Menon, B Pramodana, L Webber, I A Aneke, P Asaad, B Brown, J Collis, S Duff, A Khan, F Moura, B Wadham, H Warburton, T Elmoslemany, M Jenkinson, C Millward, R Zakaria, S Mccluney, C Parmar, S Shah, J Allison, M S Babar, B Collard, S Goodrum, K Lau, A Patel, R Scott, E Thomas, H Whitmore, D Balasubramaniam, B Jayasankar, S Kapoor, A Ramachandran, A Elhamshary, Smb Imam, K Kapriniotis, V Kasivisvanathan, J Lindsay, S Rakhshani-Moghadam, N Beech, M Chand, L Green, N Kalavrezos, H Kiconco, R McEwen, C Schilling, D Sinha, J Pereca, J Singh, S Chopra, D Egbeare, R Thomas, T Combellack, Sef Jones, M Kornaszewska, M Mohammed, A Sharma, G Tahhan, V Valtzoglou, J Williams, P Eskander, K Gash, L Gourbault, M Hanna, T Maccabe, C Newton, J Olivier, S Rozwadowski, E Teh, D West, H Al-Omishy, M Baig, H Bates, G Di Taranto, K Dickson, N Dunne, C Gill, D Howe, D Jeevan, A Khajuria, K Martin-Ucar AMcEvoy, P Naredla, V Ng, S Robertson, M Sait, D R Sarma, S Shanbhag, T Shortland, S Simmonds, J Skillman, N Tewari, G Walton, M A Akhtar, A Brunt, J McIntyre, K Milne, M M Rashid, A Sgro, K E Stewart, A Turnbull, M Aguilar Gonzalez, S Talukder, C Boyle, D Fernando, K Gallagher, A Laird, D Tham, M Bath, P Patki, C Sohrabi, C Tanabalan, T Arif, C Magee, T Nambirajan, S Powell, R Vinayagam, I Flindall, A Hanson, V Mahendran, S Green, M Lim, L MacDonald, V Miu, L Onos, K Sheridan, R Young, F Alam, O Griffiths, C Houlden, R Jones, V S Kolli, A K Lala, S Leeson, R Peevor, Z Seymour, L Chen, E Henderson, A Loehrer, K Brown, D Fleming, A Haynes, C Heron, C Hill, H Kay, E Leede, K McElhinney, K Olson, E C Osterberg, C Riley, P Srikanth, M Thornhill, D Blazer, G DiLalla, E S Hwang, W Lee, M Lidsky, J Plichta, L Rosenberger, R Scheri, K Shah, K Turnage, J Visgauss, S Zani, J Farma, J Clark, D Kwon, E Etchill, H E Gabre-Kidan AJenny, A Kent, M Ladd, C Long, H Malapati, A Margalit, S Rapaport, J Rose, K Stevens, L Tsai, D Vervoort, P Yesantharao, A Dehal, D Klaristenfeld, K Huynh, L Brown, I Ganly, J Mullinax, N Gusani, J Hazelton, J Maines, J S Oh, A Ssentongo, P Ssentongo, M Azam, A Choudhry, W Marx, J Fleming, A Fuson, J Gigliotti, A Ovaitt, Y Ying, M K Abel, V Andaya, K Bigay, M A Boeck, L Chen, H Chern, C Corvera, I El-Sayed, A Glencer, P Ha, Bcs Hamilton, C Heaton, K Hirose, D M Jablons, K Kirkwood, L Z Kornblith, J R Kratz, R Lee, P N Miller, E Nakakura, B Nunez-Garcia, R O'Donnell, D Ozgediz, P Park, B Robinson, A Sarin, B Sheu, M Varma, K Wai, R Wustrack, M J Xu, D Beswick, J Goddard, J Manor, J Song, T Fullmer, C Gaskill, N Gross, K Kiong, C L Roland, S N Zafar, M Abdallah, A Abouassi, M Almasri, G Kulkarni, H Marwan, M Mehdi, S Aoun, V S Ban, H H Batjer, J Caruso, D Abbott, A Acher, T Aiken, J Barrett, E Foley, P Schwartz, S N Zafar, A Hawkins, A Maiga, J Laufer, S Scasso
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Aged, 80 and over ,Male ,Critical Care ,SARS-CoV-2 ,International Cooperation ,COVID-19 ,Middle Aged ,Cohort Studies ,Logistic Models ,Postoperative Complications ,Elective Surgical Procedures ,Neoplasms ,Outcome Assessment, Health Care ,Humans ,Female ,Epidemics ,Aged - Abstract
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
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- 2021
8. The Emergency Surgery Frailty Index (EmSFI): development and internal validation of a novel simple bedside risk score for elderly patients undergoing emergency surgery
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Costa, Bersigotti, Gianluca, Massa, Laura, Lepre, Giulia, Fransvea, Luca, Lucarini, Pietro, Crucitti A, Mercantini, Alessio, Balducci, Paolo, Sganga, Genoveffa, Agresta, Gabriele, Alemanno, F., Anania, G., Antropoli, G., Argenio, M., Atzeni, G., Avenia, J., Azzinnaro, N., Baldazzi, A., Balducci, G., Barbera, G., Bellanova, G., Bergamini, G., Bersigotti, C., Bianchi, L., Bombardini, P. P., Borzellino, C., Bozzo, G., Brachini, S., Buonanno, G., Canini, G. M., Cardella, T., Carrara, S., Cassini, G., Castriconi, D., Ceccarelli, M., Celi, G., Ceresoli, D., Chiarugi, M., Cillara, M., Cimino, N., Cobuccio, F., Cocorullo, L., Colangelo, G., Costa, E., Crucitti, Antonio, Dalla , Caneva, A., De , Luca, P, de , Manzoni Garberini, M., Nisco, A., Prizio, C., Sol, M., Dibella, A., Falcioni, A., Falco, T., Farina, N., Finotti, C., Fontana, E., Francioni, T., Fransvea, G., Frezza, P., Garbarino, B., Garulli, G., Genna, G., Giannessi, M., Gioffrè, S., Giordano, A., Gozzo, A., Grimaldi, D., Gulotta, S., Iacopini, G., Iarussi, V., Laracca, T., Laterza, G., Leonardi, E., Lepre, A., Lorenzon, L., Luridiana, L., Malagnino, G., Mar, A., Marini, G., Marzaioli, P., Massa, R., Mecarelli, G., Mercantini, V., Mingoli, P., Nigri, A., Occhionorelli, G., Paderno, S., Palini, N., Paradies, G. M., Paroli, D., Perrone, M., Petrucciani, F., Petruzzelli, N., Pezzolla, L., Piazza, A., Piazza, D., Piccoli, V., Pisanu, M., Podda, A., Poillucci, M., Porfidia, G., Rossi, R., Ruscelli, G., Spagnoli, P., Sulis, A., Tartaglia, R., Tranà, D., Travaglino, C., Tomaiuolo, A., Valeri, P., Vasquez, A., Zago, G., Zanoni, M., null, E., Null, Crucitti (ORCID:0000-0003-3496-4185), Costa, Bersigotti, Gianluca, Massa, Laura, Lepre, Giulia, Fransvea, Luca, Lucarini, Pietro, Crucitti A, Mercantini, Alessio, Balducci, Paolo, Sganga, Genoveffa, Agresta, Gabriele, Alemanno, F., Anania, G., Antropoli, G., Argenio, M., Atzeni, G., Avenia, J., Azzinnaro, N., Baldazzi, A., Balducci, G., Barbera, G., Bellanova, G., Bergamini, G., Bersigotti, C., Bianchi, L., Bombardini, P. P., Borzellino, C., Bozzo, G., Brachini, S., Buonanno, G., Canini, G. M., Cardella, T., Carrara, S., Cassini, G., Castriconi, D., Ceccarelli, M., Celi, G., Ceresoli, D., Chiarugi, M., Cillara, M., Cimino, N., Cobuccio, F., Cocorullo, L., Colangelo, G., Costa, E., Crucitti, Antonio, Dalla , Caneva, A., De , Luca, P, de , Manzoni Garberini, M., Nisco, A., Prizio, C., Sol, M., Dibella, A., Falcioni, A., Falco, T., Farina, N., Finotti, C., Fontana, E., Francioni, T., Fransvea, G., Frezza, P., Garbarino, B., Garulli, G., Genna, G., Giannessi, M., Gioffrè, S., Giordano, A., Gozzo, A., Grimaldi, D., Gulotta, S., Iacopini, G., Iarussi, V., Laracca, T., Laterza, G., Leonardi, E., Lepre, A., Lorenzon, L., Luridiana, L., Malagnino, G., Mar, A., Marini, G., Marzaioli, P., Massa, R., Mecarelli, G., Mercantini, V., Mingoli, P., Nigri, A., Occhionorelli, G., Paderno, S., Palini, N., Paradies, G. M., Paroli, D., Perrone, M., Petrucciani, F., Petruzzelli, N., Pezzolla, L., Piazza, A., Piazza, D., Piccoli, V., Pisanu, M., Podda, A., Poillucci, M., Porfidia, G., Rossi, R., Ruscelli, G., Spagnoli, P., Sulis, A., Tartaglia, R., Tranà, D., Travaglino, C., Tomaiuolo, A., Valeri, P., Vasquez, A., Zago, G., Zanoni, M., null, E., Null, and Crucitti (ORCID:0000-0003-3496-4185)
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Background Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emergency surgery. Study design 1024 patients older than 65 years who required urgent surgical procedures were prospectively recruited from 38 Italian centers participating to the multicentric FRAILESEL (Frailty and Emergency Surgery in the Elderly) study, between December 2016 and May 2017. A univariate analysis was carried out, with the purpose of developing a frailty index in emergency surgery called "EmSFI". Receiver operating characteristic curve analysis was then performed to test the accuracy of our predictive score. Results 784 elderly patients were consecutively enrolled, constituting the development set and results were validated considering further 240 consecutive patients undergoing colorectal surgical procedures. A logistic regression analysis was performed identifying different EmSFI risk classes. The model exhibited good accuracy as regard to mortality for both the development set (AUC = 0.731 [95% CI 0.654-0.772]; HL test chi(2) = 6.780; p = 0.238) and the validation set (AUC = 0.762 [95% CI 0.682-0.842]; HL test chi(2) = 7.238; p = 0.299). As concern morbidity, our model showed a moderate accuracy in the development group, whereas a poor discrimination ability was observed in the validation cohort. Conclusions The validated EmSFI represents a reliable and time-sparing tool, despite its discriminative value decreased regarding complications. Thus, further studies are needed to investigate specifically surgical settings, validating the EmSFI prognostic role in assessing the procedure-related morbidity risk.
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- 2020
9. Verocytotoxin-producing Escherichia coli O157 in minced beef and dairy products in Italy
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Conedera, G., Dalvit, P., Martini, M., Galiero, G., Gramaglia, M., Goffredo, E., Loffredo, G., Morabito, S., Ottaviani, D., Paterlini, F., Pezzotti, G., Pisanu, M., Semprini, P., and Caprioli, A.
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- 2004
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10. Detection of Human Bocavirus Species 2 and 3 in Bivalve Shellfish in Italy
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La Rosa, G., primary, Purpari, G., additional, Guercio, A., additional, Di Bella, S., additional, Gucciardi, F., additional, Proroga, Y. T. R., additional, Pisanu, M., additional, Della Libera, S., additional, Iaconelli, M., additional, and Suffredini, E., additional
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- 2018
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11. Microbiological survey of raw and ready-to-eat leafy green vegetables marketed in Italy
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Losio, M.N., Pavoni, E., Bilei, S., Bertasi, B., Bove, D., Capuano, F., Farneti, S., Blasi, G., Comin, D., Cardamone, C., Decastelli, L., Delibato, E., De Santis, P., Di Pasquale, S., Gattuso, A., Goffredo, E., Fadda, A., Pisanu, M., and De Medici, D.
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- 2015
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12. Safety characteristics of bridleways
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Denti M., Pisanu M., Usai E., Casazza S., CHECCHI, ANTONIO, Denti M., Pisanu M., Usai E., Checchi A., and Casazza S.
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SAFETY ,BRIDLEWAY ,HORSE - Abstract
The world of equestrian exhibitions aims most of its attention on the overall image and glamour, without focusing organizational strains on safety among public, workers and horses. Preventing accidents on workplaces means protecting the safeness of people, both public and workers, and animals. The not easy definition of risks in the equestrian range rises from the extreme variability and arduous foreseeing of working states and from the considerable number of activities which are often simultaneously performed. The objective is to reach a real optimization of safety in equestrian exhibitions, fairs and expositions, developing a level of attention in the areas of safety for people, workers and horses, so that a good degree of protection can be reached in a global and commensurate way. Only applying some simple but basic rules, it will be possible to grant a complete and effective safety in the framework of every respectable equestrian show.
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- 2010
13. The salivary proteome profile in patients affected by SAPHO syndrome characterized by a top-down RP-HPLC-ESI-MS platform
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Sanna, M, Firinu, D, Manconi, Pe, Pisanu, M, Murgia, G, Piras, V, Castagnola, Massimo, Messana, I, Del Giacco, Sr, Cabras, T., Castagnola, Massimo (ORCID:0000-0002-0959-7259), Sanna, M, Firinu, D, Manconi, Pe, Pisanu, M, Murgia, G, Piras, V, Castagnola, Massimo, Messana, I, Del Giacco, Sr, Cabras, T., and Castagnola, Massimo (ORCID:0000-0002-0959-7259)
- Abstract
SAPHO syndrome is a rare and often unrecognized disease with prominent inflammatory cutaneous and articular symptoms characterized by musculoskeletal manifestations (synovitis, hyperostosis, osteomyelitis) associated with dermatological conditions (severe acne and pustulosis). The acidic soluble fraction of whole saliva from 10 adult women affected by SAPHO syndrome and from a group of 28 healthy women was analysed by RP-HPLC-ESI-MS with the aim of discovering salivary biomarkers of the disorder. The levels of the oral proteins and peptides were correlated with clinical data. The following proteins showed a significant decreased concentration in saliva of SAPHO subjects with respect to controls: cystatin S1 and SN, histatins, the major acidic PRPs, P-C and P-B peptides. The cystatin SN abundance lowered according to the disease duration and histatins showed positive correlations with the C reactive protein. Statistical analysis performed excluding one patient with a different pattern of salivary proteins/peptides highlighted a positive relationship between cystatin S1, histatins 3, histatin 5, and the neutrophil count. Moreover, histatin 3 correlated positively with the total white cell count and negatively with the erythrocyte sedimentation rate. Levels and frequency of S100A12 protein showed a trend to increase in SAPHO patients. The high expression of this pro-inflammatory protein is probably related to the inflammatory response and to the altered neutrophil responses to functional stimuli that characterize SAPHO syndrome suggesting a possible application as a salivary biomarker.
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- 2015
14. A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial
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Ruggeri, Mirella, Bonetto, Chiara, Lasalvia, Antonio, Girolamo, De, G, Fioritti, A, Rucci, P, Santonastaso, P, Neri, G, Pileggi, F, Ghigi, D, Miceli, M, Scarone, S, Cocchi, A, Torresani, S, Faravelli, C, Zimmermann, Christa, Meneghelli, A, Cremonese, C, Scocco, P, Leuci, E, Mazzi, F, Gennarelli, M, Brambilla, P, Bissoli, S, Bertani, Me, Tosato, Sarah, DE SANTI, Katia, Poli, Sara, Cristofalo, Doriana, Tansella, Michele, Get, Up, Group, Ruggeri, M, Mirella, Me, Bonetto, C, Cristofalo, D, De Santi, K, Lasalvia, A, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, Mg, Ballarin, M, Bocchio, Chiavetto, L, Scasselatti, C, Zanardini, R, Bellani, Marcella, Bertoldo, A, Marinelli, Veronica, Perlini, Cinzia, Rambaldelli, Gianluca, Bertani, M, Lazzarotto, L, Bardella, S, Gardellin, F, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosì, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefan, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, Claudia, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Ald, F, Bianchi, B, Cappellari, P, Conti, R, Battisti, De, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visonà, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Veronese, A, Anderle, P, Angelozz, A, Amalric, I, Baron, G, Candeago, Eb, Castelli, F, Chieco, M, Costanzo, Di, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanz, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, Risio, De, A, Gatto, A, Granà, S, Favero, E, Franceschin, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Bortolo, Di, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, Dominoni, A, Andreose, L, Boemio, M, Bressan, L, Cabbia, A, Canesso, E, Cian, R, Dal, Piccol, Dalla, C, Pasqua, Mm, Prisco, Di, Mantellato, L, Luison, M, Morgante, S, Santi, M, Sacillotto, M, Scabbio, M, Sponga, P, Sguotto, Ml, Stach, F, Vettorato, Mg, Martinello, G, Dassiè, F, Marino, S, Cibiniel, L, Masetto, I, Cabianca, O, Valente, A, Caberlotto, L, Passoni, A, Flumian, P, Daniel, L, Gion, M, Stanziale, S, Alborino, F, Bortolozzo, V, Bacelle, L, Bicciato, L, Basso, D, Navaglia, F, Manoni, F, Ercolin, M, Giubilini, F, Imbesi, M, Semrov, E, Giovanni, Cs, Taro, E, Ceno, V, Ovest, P, Anelli, S, Amore, M, Bigi, L, Britta, W, Anna, Gb, Bonatti, U, Borziani, M, Crosato, I, Galluccio, R, Galeotti, M, Gozzi, M, Greco, V, Guagnini, E, Pagani, S, Maccherozzi, M, Marchi, F, Melato, E, Mazzucchi, E, Marzullo, F, Pellegrini, P, Petrolini, N, Volta, P, Bonara, F, Brusamonti, E, Croci, R, Flamia, I, Fontana, F, Losi, R, Marchioro, R, Raffaini, L, Ruju, L, Saginario, A, Tondelli, Mg, Marrama, D, Bernardelli, L, Bonacini, F, Florindo, A, Merli, M, Nappo, P, Sola, L, Tondelli, O, Tonna, M, Torre, Mt, Tosatti, M, Venturelli, G, Zampolla, D, Bernardi, A, Cavalli, C, Cigala, L, Ciraudo, C, Bari, Di, Ferri, L, Gombi, F, Leurini, S, Mandatelli, E, Maccaferri, S, Oroboncoide, M, Pisa, B, Ricci, C, Poggi, E, Zurlini, C, Malpeli, M, Colla, R, Teodori, E, Vecchia, L, D'Andrea, R, Trenti, T, Paolini, P, Carpeggiani, P, Gagliostro, M, Pratelli, M, Lazzaro, S, Antonelli, A, Battistini, L, Bellini, F, Bonini, E, Capelli, Cb, Didomizio, C, Drei, C, Fucci, G, Gualandi, A, Grazia, Mr, Losi, Am, Mazzoni, Fm, Marangoni, D, Monna, G, Morselli, M, Oggioni, A, Oprandi, S, Paganelli, W, Passerini, M, Piscitelli, M, Reggiani, G, Rossi, G, Salvatori, F, Trasforini, S, Uslenghi, C, Veggetti, S, Bartolucci, G, Baruffa, R, Bertelli, R, Borghi, L, Ciavarella, P, Paltrinieri, E, Rizzardi, F, Serra, P, Suzzi, D, Carlo, U, Arienti, P, Aureli, F, Avanzi, R, Callegari, V, Corsino, A, Host, P, Michetti, R, Rizzo, F, Simoncelli, P, Soldati, E, Succi, E, Bertozzi, M, Canetti, E, Cavicchioli, L, Ceccarelli, E, Cenni, S, Marzola, G, Gallina, V, Leoni, C, Olivieri, A, Piccolo, E, Ravagli, S, Russo, R, Tedeschini, D, Verenini, M, Abram, W, Granata, V, Curcio, A, Guerra, G, Granini, S, Natali, L, Montanari, E, Pasi, F, Ventura, U, Valenti, S, Francesca, M, Farneti, R, Ravagli, P, Floris, R, Maroncelli, O, Volpones, G, Casali, D, Bencini, A, Cellini, M, Biase, De, Barbara, L, Charles, L, Pratesi, C, Tanini, A, Loparrino, R, Ulivelli, C, Cussoto, C, Dei, N, Fumanti, E, Pantani, M, Zeloni, G, Bellini, R, Cellesi, R, Dorigo, N, Gullì, P, Ialeggio, L, Pisanu, M, Rinaldi, G, Konze, A, Modignani, L, Frova, M, Monzani, E, Zanobio, A, Malagoli, M, Pagani, R, Barbera, S, Morganti, C, Amadè, Es, Brambilla, V, Montanari, A, Caterina, G, Lopez, C, Marocchi, A, Moletta, A, Sberna, M, Cascio, Mt, Manzone, Ml, Barbara, B, Mari, L, Razzini, E, Bianchi, Y, Pellizzer, Mr, Verdecchia, A, Sferrazza, Mg, Pismataro, R, D'Eril, Gv, Barassi, A, Pacciolla, R, Faraci, G, Rosmini, B, Carpi, F, Soelva, M, Anderlan, M, Francesco, De, M, Duregger, E, Vettori, C, Doimo, S, Kompatscher, E, Forer, M, Kerschbaumer, H, Gampe, A, Nicoletti, M, Acerbi, C, Aquilino, D, Azzali, S, Bensi, L, Cappellari, D, Casana, E, Campagnola, N, Dal, Corso, Di, E, Micco, E, Gobbi, E, Mairaghi, L, Malak, S, Mesiano, L, Paterlini, F, Perini, M, Puliti, Em, Rispoli, R, Rizzo, E, Sergenti, C, Soave, M, Alpi, A, Bislenghi, L, Bolis, T, Colnaghi, F, Fascendini, S, Grignani, S, Patelli, G, Casale, S, Zimmermann, C, Deledda, G, Goss, C, Mazzi, Maria Angela, Rimondini, Michela, Scassellati, C, Bonvicini, C, Longo, S, Ventriglia, M, Squitti, R, Frisoni, G, Pievani, M, Balestrieri, M, Perlini, C, Marinelli, V, Bellani, M, Rambaldelli, G, Atzori, M, Beltramello, A, Alessandrini, F, Pizzini, Francesca, Zoccatelli, G, Politi, P, Emanuele, E, Brondino, N, Martino, G, Bergami, A, Zarbo, R, Riva, Ma, Fumagalli, F, Molteni, R, Calabrese, F, Guidotti, G, Luoni, A, Macchi, F, Artioli, S, Baldetti, M, Bizzocchi, M, Bolzon, D, Bonello, E, Cacciari, G, Carraresi, C, Caselli, G, Furlato, K, Garlassi, S, Gavarini, A, Macchetti, F, Marteddu, V, Plebiscita, G, Totaro, S, Bebbington, P, Birchwood, M, Dazzan, P, Kuipers, E, Thornicroft, G, Pariante, C, Lawrie, S, Soares, J. C., Ruggeri, M., Bonetto, C., Lasalvia, A., De Girolamo, G., Bertani, M., Rucci, P., Santonastaso, P., Neri, G., Pileggi, F., Ghigi, D., Miceli, M., Scarone, S., Cocchi, A., Torresani, S., Faravelli, C., Zimmermann, C., Meneghelli, A., Cremonese, C., Scocco, P., Leuci, E., Mazzi, F., Gennarelli, Massimo, Brambilla, P., Bissoli, S., Lazzarotto, L., Bardella, S., Gardellin, F., Lamonaca, D., Lunardon, M., Magnabosco, R., Martucci, M., Nicolau, S., Nifosì, F., Bertani, M. E., Tosato, S., De Santi, K., Poli, S., Cristofalo, D., Tansella, Michele, Lunardi, S., Negretto, V., Zamboni, M. G., Ballarin, M., Chiavetto, Luisella Bocchio, Scasselatti, C., Zanardini, R., Bellani, M., Bertoldo, A., Marinelli, Valentina, Perlini, C., Rambaldelli, G., Pasqualini, A., Pavanati, M., Rossi, M., Piazza, C., Piccione, G., Sala, A., Roccato, S., Rossi-, A., Sale, A., Stefan, B., Strizzolo, S., Zotos, S., Balbo, M., Boggian, I., Ceccato, E., Dall’Agnola, R., Girotto, B., Leoni, R., Mai, A., Urbani, Alessandro, Ald, F., Bianchi, Benedetta, Cappellari, P., Conti, R., De Battisti, L., Lazzarin, E., Merlin, S., Migliorini, G., Pozzan, T., Sarto, L., Visonà, S., Brazzoli, A., Campi, A., Carmagnani, R., Giambelli, S., Gianella, A., Lunardi-, L., Madaghiele, D., Maestrelli, P., Paiola, L., Posteri, E., Viola, L., Zamberlan, V., Zenari, M., Zanoni, M., Bonadonna, G., Bonomo, M., Veronese, A., Anderle, P., Angelozz, A., Amalric, I., Baron, G., Candeago, E. B., Castelli, F., Chieco, M., Di Costanzo, E., Derossi, M., Doriguzzi, M., Galvano, O., Lattanz, M., Lezzi, R., Marcato, M., Marcolin, A., Marini, F., Matranga, M., Scalabrin, D., Zucchetto, M., Zadro, F., Austoni, G., Bianco, M., Bordino, F., Dario, F., DE RISIO, Alfredo, Gatto, A., Granà, S., Favero, E., Franceschin, A., Friederici, S., Marangon, V., Pascolo, M., Ramon, L., Zambolin, S., Riolo, R., Buffon, A., Di Bortolo, E., Fortin, S., Matarrese, F., Mogni, S., Codemo, N., Russi, A., Silvestro, Antonina, Turella, E., Viel, P., Dominoni, A., Andreose, L., Boemio, M., Bressan, L., Cabbia, A., Canesso, E., Cian, R., Dal Piccol, C., Dalla Pasqua, M. M., Di Prisco, A., Mantellato, L., Luison, M., Morgante, S., Santi, M., Sacillotto, M., Scabbio, M., Sponga, P., Sguotto, M. L., Stach, F., Vettorato, M. G., Martinello, G., Dassiè, F., DI MARINO, Simone, Cibiniel, L., Masetto, I., Cabianca, O., Valente, MADDALENA AGNESE, Caberlotto, L., Passoni, A., Flumian, P., Daniel, L., Gion, M., Stanziale, S., Alborino, F., Bortolozzo, V., Bacelle, L., Bicciato, L., Basso, D., Navaglia, F., Manoni, F., Ercolin, M., Giubilini, F., Imbesi, M., Semrov, E., Giovanni, C. S., Taro e Ceno, V., Ovest, P., Anelli, S., Amore, M., Bigi, L., Britta, W., Anna, G. B., Bonatti, U., Borziani, M., Crosato, I., Galluccio, R., Galeotti, M., Gozzi, M., Greco, V., Guagnini, E., Pagani, S., Maccherozzi, M., Marchi, F., Melato, E., Mazzucchi, E., Marzullo, F., Pellegrini, Pietro Carlo, Petrolini, N., Volta, P., Bonara, F., Brusamonti, E., Croci, R., Flamia, I., Fontana, F., Losi, R., Marchioro, R., Raffaini, L., Ruju, L., Saginario, A., Tondelli, M. G., Marrama, D., Bernardelli, L., Bonacini, F., Florindo, A., Merli, M., Nappo, P., Sola, L., Tondelli-, O., Tonna, M., Torre, M. T., Tosatti, M., Venturelli, G., Zampolla, D., Bernardi, A., Cavalli, Chiara, Cigala, L., Ciraudo, C., Di Bari, A., Ferri, L., Gombi, F., Leurini, S., Mandatelli, E., Maccaferri, S., Oroboncoide, M., Pisa, B., Ricci, Carmine, Poggi, E., Zurlini, C., Malpeli, M., Colla, R., Teodori, E., Vecchia, L., D’Andrea, R., Trenti, T., Paolini, P., Carpeggiani, P., Gagliostro, M., Pratelli, M., Lazzaro, S., Antonelli, A., Battistini, Luca, Bellini, Fiorella, Bonini, E., Capelli, C. B., Didomizio, C., Drei, C., Fucci, G., Gualandi, A., Grazia, M. R., Losi-, A. M., Mazzoni, F. M., Marangoni, D., Monna, G., Morselli, M., Oggioni, A., Oprandi, S., Paganelli, W., Passerini, M., Piscitelli, M., Reggiani, G., Rossi-, G., Salvatori, Franco, Trasforini, S., Uslenghi, C., Veggetti, S., Bartolucci, Giuliana, Baruffa, R., Bertelli, R., Borghi, L., Ciavarella, P., Paltrinieri, E., Rizzardi, F., Serra, P., Suzzi, D., Carlo, U., Arienti, P., Aureli, F., Avanzi, R., Callegari, V., Corsino, A., Host, P., Michetti, R., Rizzo, F., Simoncelli, P., Soldati, E., Succi, E., Bertozzi, M., Canetti, E., Cavicchioli, L., Ceccarelli, E., Cenni, S., Marzola, G., Gallina, V., Leoni, C., Olivieri, A., Piccolo, Elisa, Ravagli, S., Russo, R., Tedeschini, D., Verenini, M., Abram, W., Granata, V., Curcio, A., Guerra, G., Granini, S., Natali, L., Montanari, Eleonora, Pasi, F., Ventura, U., Valenti, S., Francesca, M., Farneti, R., Ravagli-, P., Floris, R., Maroncelli, O., Volpones, G., Casali, D., Bencini, A., Cellini, M., De Biase, L., Barbara, L., Charles, L., Pratesi, C., Tanini, A., Loparrino, R., Ulivelli, C., Cussoto, C., Dei, N., Fumanti, E., Pantani, M., Zeloni, G., Bellini-, R., Cellesi, R., Dorigo, N., Gullì, P., Ialeggio, L., Pisanu, M., Rinaldi, G., Konze, A., Modignani, L., Frova, M., Monzani, E., Amadè, E. S., Zanobio, A., Malagoli, M., Pagani-, R., Barbera, S., Morganti, C., Brambilla-, V., Montanari-, A., Caterina, G., LOPEZ CORTES, Carlo, Marocchi, A., Moletta, A., Sberna, M., Cascio, M. T., Manzone, M. L., Barbara-, B., Mari, L., Razzini, E., Bianchi-, Y., Pellizzer, M. R., Verdecchia, A., Sferrazza, M. G., Pismataro, R., D’Eril, G. V., Barassi, A., Pacciolla, R., Faraci, G., Rosmini, B., Carpi, F., Soelva, M., Anderlan, M., De Francesco, M., Duregger, E., Vettori, C., Doimo, S., Kompatscher, E., Forer, M., Kerschbaumer, H., Gampe, A., Nicoletti, M., Acerbi, C., Aquilino, D., Azzali, S., Bensi, L., Cappellari-, D., Casana, E., Campagnola, N., Dal Corso, E., Di Micco, E., Gobbi, E., Mairaghi, L., Malak, S., Mesiano, L., Paterlini, F., Perini, Matteo, Puliti, E. M., Rispoli, R., Rizzo-, E., Sergenti, C., Soave, M., Alpi, A., Bislenghi, L., Bolis, T., Colnaghi, F., Fascendini, S., Grignani, S., Patelli, G., Casale, S., Deledda, G., Goss, C., Mazzi-, M., Rimondini, M., Scassellati, C., Bonvicini, C., Longo, Salvatore, Bocchio Chiavetto, L., Ventriglia, M., Squitti, R., Frisoni, G., Pievani, M., Balestrieri, M., Atzori, M., Beltramello, A., Alessandrini, F., Pizzini, F., Zoccatelli, G., Politi, P., Emanuele, E., Brondino, N., Martino, G., Bergami, A., Zarbo, R., Riva, M. A., Fumagalli, F., Molteni, R., Calabrese, F., Guidotti, Giovanni, Luoni, Alessia, Macchi, F., Artioli, S., Baldetti, M., Bizzocchi, M., Bolzon, D., Bonello, E., Cacciari, G., Carraresi, C., Caselli, G., Furlato, K., Garlassi, S., Gavarini, A., Macchetti, F., Marteddu, V., Plebiscita, G., Totaro, S., Bebbington, P., Birchwood, M., Dazzan, P., Kuipers, E., Thornicroft, G., Pariante, C., Lawrie, S., Soares, J. C., Mirella Ruggeri, Chiara Bonetto, Antonio Lasalvia, Giovanni De Girolamo, Angelo Fioritti, Paola Rucci, Paolo Santonastaso, Giovanni Neri, Francesca Pileggi, Daniela Ghigi, Maurizio Miceli, Silvio Scarone, Angelo Cocchi, Stefano Torresani, Carlo Faravelli, Christa Zimmermann, Anna Meneghelli, Carla Cremonese, Paolo Scocco, Emanuela Leuci, Fausto Mazzi, Massimo Gennarelli, Paolo Brambilla, Sarah Bissoli, Maria Elena Bertani, Sarah Tosato, Katia De Santi, Sara Poli, Doriana Cristofalo, Michele Tansella, and and THE GET UP GROUP
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Research design ,Time Factors ,early psychosis, psychosocial interventions, cluster randomized triales ,medicine.medical_treatment ,Psychological intervention ,Medicine (miscellaneous) ,Assertive community treatment ,Severity of Illness Index ,law.invention ,Study Protocol ,Randomized controlled trial ,law ,Recurrence ,Early psychosi ,Cluster Analysis ,Pharmacology (medical) ,lcsh:R5-920 ,Family Relation ,Community Mental Health Service ,First-episode psychosis ,Community Mental Health Center ,Community Mental Health Services ,Cognitive behavioral therapy ,Treatment Outcome ,Cognitive Therapy ,Italy ,Research Design ,First-episode psychosisEarly psychosisCognitive behavioral therapyPsychosocial interventionAssertive community treatment ,Family Relations ,lcsh:Medicine (General) ,Psychosocial ,Human ,pragmatic trial ,Early psychosis ,Family intervention ,Psychosocial intervention ,Community Mental Health Centers ,Humans ,Patient Selection ,Psychotic Disorders ,Sample Size ,Case Management ,Cognitive Behavioral Therapy ,medicine.medical_specialty ,psychosocial interventions ,Time Factor ,cluster randomized triales ,Psychotic Disorder ,First-episode psychosi ,medicine ,Psychiatry ,Cluster Analysi ,business.industry ,Mental health ,Cognitive therapy ,business - Abstract
Background Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in ‘real-world’ services. Methods/Design The Psychosis early Intervention and Assessment of Needs and Outcome (PIANO) trial is part of a larger research program (Genetics, Endophenotypes and Treatment: Understanding early Psychosis - GET UP) which aims to compare, at 9 months, the effectiveness of a multi-component psychosocial intervention versus treatment as usual (TAU) in a large epidemiologically based cohort of patients with FEP and their family members recruited from all public community mental health centers (CMHCs) located in two entire regions of Italy (Veneto and Emilia Romagna), and in the cities of Florence, Milan and Bolzano. The GET UP PIANO trial has a pragmatic cluster randomized controlled design. The randomized units (clusters) are the CMHCs, and the units of observation are the centers’ patients and their family members. Patients in the experimental group will receive TAU plus: 1) cognitive behavioral therapy sessions, 2) psycho-educational sessions for family members, and 3) case management. Patient enrolment will take place over a 1-year period. Several psychopathological, psychological, functioning, and service use variables will be assessed at baseline and follow-up. The primary outcomes are: 1) change from baseline to follow-up in positive and negative symptoms’ severity and subjective appraisal; 2) relapse occurrences between baseline and follow-up, that is, episodes resulting in admission and/or any case-note records of re-emergence of positive psychotic symptoms. The expected number of recruited patients is about 400, and that of relatives about 300. Owing to the implementation of the intervention at the CMHC level, the blinding of patients, clinicians, and raters is not possible, but every effort will be made to preserve the independency of the raters. We expect that this study will generate evidence on the best treatments for FEP, and will identify barriers that may hinder its feasibility in ‘real-world’ clinical settings, patient/family conditions that may render this intervention ineffective or inappropriate, and clinical, psychological, environmental, and service organization predictors of treatment effectiveness, compliance, and service satisfaction. Trial registration ClinicalTrials.gov Identifier NCT01436331
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- 2012
15. Prevalence of Escherichia coli O157 in ground beef and dairy products in Italy
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Conedera, G, Caprioli, A., Dalvit, P., Martini, Marco, Galiero, G., Gramaglia, M., Goffredo, E., Loffredo, G., Morabito, S., Ottavini, D., Pezzetti, G., Pisanu, M., and Semprini, P.
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- 2003
16. Monitoring response to cytostatic cisplatin in a HER2(+) ovary cancer model by MRI and in vitro and in vivo MR spectroscopy
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Pisanu, M E, primary, Ricci, A, additional, Paris, L, additional, Surrentino, E, additional, Liliac, L, additional, Bagnoli, M, additional, Canevari, S, additional, Mezzanzanica, D, additional, Podo, F, additional, Iorio, E, additional, and Canese, R, additional
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- 2013
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17. Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer
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Granata, A, primary, Nicoletti, R, additional, Tinaglia, V, additional, De Cecco, L, additional, Pisanu, M E, additional, Ricci, A, additional, Podo, F, additional, Canevari, S, additional, Iorio, E, additional, Bagnoli, M, additional, and Mezzanzanica, D, additional
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- 2013
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18. STUDY ON THE NOROVIRUS PRESENCE IN MYTILUS GALLOPROVINCIALIS SUBJECTED TO DEPURATION IN TWO C.D.Ms. IN THE SARDINIA REGION
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Bazzardi, R., primary, Pisanu, M., additional, Fattaccio, M.C., additional, Canu, A., additional, Marongiu, E., additional, Serra, S., additional, and Fadda, G., additional
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- 2012
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19. EFFICACY OF DEPURATION ON SAFETY OF MEDITERRANEAN MUSSELS (Mytilus galloprovincialis) REARED IN THE OLBIA GULF
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Meloni, D., primary, Mureddu, A., additional, Pisanu, M., additional, Serra, S., additional, Piras, A., additional, Virgilio, S, additional, and Mazzette, R., additional
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- 2008
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20. Monitoring response to cytostatic cisplatin in a HER2(+) ovary cancer model by MRI and in vitro and in vivo MR spectroscopy.
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Pisanu, M E, Ricci, A, Paris, L, Surrentino, E, Liliac, L, Bagnoli, M, Canevari, S, Mezzanzanica, D, Podo, F, Iorio, E, and Canese, R
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OVARIAN cancer treatment , *ANTINEOPLASTIC agents , *CISPLATIN , *HER2 gene , *MAGNETIC resonance imaging of cancer , *NUCLEAR magnetic resonance spectroscopy - Abstract
Background:Limited knowledge is available on alterations induced by cytostatic drugs on magnetic resonance spectroscopy (MRS) and imaging (MRI) parameters of human cancers, in absence of apoptosis or cytotoxicity. We here investigated the effects of a cytostatic cisplatin (CDDP) treatment on 1H MRS and MRI of HER2-overexpressing epithelial ovarian cancer (EOC) cells and in vivo xenografts.Methods:High-resolution MRS analyses were performed on in vivo passaged SKOV3.ip cells and cell/tissue extracts (16.4 or 9.4 T). In vivo MRI/MRS quantitative analyses (4.7 T) were conducted on xenografts obtained by subcutaneous implantation of SKOV3.ip cells in SCID mice. The apparent diffusion coefficient (ADC) and metabolite levels were measured.Results:CDDP-induced cytostatic effects were associated with a metabolic shift of cancer cells towards accumulation of MRS-detected neutral lipids, whereas the total choline profile failed to be perturbed in both cultured cells and xenografts. In vivo MRI examinations showed delayed tumour growth in the CDDP-treated group, associated with early reduction of the ADC mean value.Conclusion:This study provides an integrated set of information on cancer metabolism and physiology for monitoring the response of an EOC model to a cytostatic chemotherapy, as a basis for improving the interpretation of non-invasive MR examinations of EOC patients. [ABSTRACT FROM AUTHOR]
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- 2014
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21. Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer.
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Granata, A, Nicoletti, R, Tinaglia, V, De Cecco, L, Pisanu, M E, Ricci, A, Podo, F, Canevari, S, Iorio, E, Bagnoli, M, and Mezzanzanica, D
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OVARIAN cancer treatment ,CHOLINE kinase ,TARGETED drug delivery ,CELL metabolism ,PHOSPHOCHOLINE ,GENE expression - Abstract
Background:Aberrant choline metabolism has been proposed as a novel cancer hallmark. We recently showed that epithelial ovarian cancer (EOC) possesses an altered MRS-choline profile, characterised by increased phosphocholine (PCho) content to which mainly contribute over-expression and activation of choline kinase-alpha (ChoK-alpha).Methods:To assess its biological relevance, ChoK-alpha expression was downmodulated by transient RNA interference in EOC in vitro models. Gene expression profiling by microarray analysis and functional analysis was performed to identify the pathway/functions perturbed in ChoK-alpha-silenced cells, then validated by in vitro experiments.Results:In silenced cells, compared with control, we observed: (I) a significant reduction of both CHKA transcript and ChoK-alpha protein expression; (II) a dramatic, proportional drop in PCho content ranging from 60 to 71%, as revealed by
1 H-magnetic spectroscopy analysis; (III) a 35-36% of cell growth inhibition, with no evidences of apoptosis or modification of the main cellular survival signalling pathways; (IV) 476 differentially expressed genes, including genes related to lipid metabolism. Ingenuity pathway analysis identified cellular functions related to cell death and cellular proliferation and movement as the most perturbed. Accordingly, CHKA-silenced cells displayed a significant delay in wound repair, a reduced migration and invasion capability were also observed. Furthermore, although CHKA silencing did not directly induce cell death, a significant increase of sensitivity to platinum, paclitaxel and doxorubicin was observed even in a drug-resistant context.Conclusion:We showed for the first time in EOC that CHKA downregulation significantly decreased the aggressive EOC cell behaviour also affecting cells' sensitivity to drug treatment. These observations open the way to further analysis for ChoK-alpha validation as a new EOC therapeutic target to be used alone or in combination with conventional drugs. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
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22. Prevalence of thermotolerant Campylobacter in broiler flocks and broiler carcasses in Italy
- Author
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Di Giannatale, E., Prencipe, V., Colangeli, P., Alessiani, A., Lisa Barco, Staffolani, M., Tagliabue, S., Grattarola, C., Cerrone, A., Costa, A., Pisanu, M., Santucci, U., Iannitto, G., and Migliorati, G.
- Subjects
Hot Temperature ,lcsh:Veterinary medicine ,Broiler ,Carcass ,Campylobacter ,fluids and secretions ,Italy ,Caeca ,Prevalence ,Animals ,lcsh:SF600-1100 ,lcsh:Animal culture ,Cecum ,Chickens ,Abattoirs ,lcsh:SF1-1100 - Abstract
In accordance with European Union regulations, from 5 February until 15 December 2008, sampling and analysis activities were conducted in Italy to assess the extent of contamination caused by thermotolerant Campylobacter in broiler chickens farmed nationwide. The survey involved 48 poultry slaughterhouses distributed across eleven regions of Italy, where the caeca and carcasses of 393 slaughter batches were sampled. A total of 284 batches (72.3%) gave positive results for Campylobacter spp. as follows: 52.1% were contaminated by C. jejuni, 55.6% by C. coli and 1.1% by C. lari. C. jejuni and C. coli were isolated together in 37 batches (13% of positive results). Campylobacter spp. was isolated only from the caeca in 251 slaughter batches (63.9%) including caecal isolates of C. jejuni (48.2%), C. coli (50.6%), and C. lari (1.2%). Carcasses from 182 batches (46.3%) were contaminated by C. jejuni in 40.7% of cases, C. coli in 57.7% and the absence of C. lari from all batches examined. The contamination level observed in the carcasses ranged between 10 and 1.6 × 10(7) cfu/g.
23. Phosphatidylcholine-specific phospholipase c as a new molecular target to weaken the effects of her2 amplification in breast carcinoma
- Author
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Paris, L., Cecchetti, S., Abalsamo, L., Spadaro, F., Luana Lugini, Pisanu, M. E., Iorio, E., Natali, P. G., Ramoni, C., and Podo, F.
24. Aberrant phosphatidylcholine metabolism as source of biomarkers and therapeutic targets in human ovarian cancer
- Author
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Iorio, E., Ricci, A., Pisanu, M. E., Bagnoli, M., Cecco, L., Mezzanzanica, D., Canese, R., Francesca Spadaro, Canevari, S., and Podo, F.
25. Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis
- Author
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Carlo Leonetti, Erica Salvati, Chiara Cingolani, M. E. Pisanu, Annamaria Biroccio, Anna Bagnato, A. Rizzo, Ettore Novellino, Carmen D'Angelo, Eric Gilson, Antonio Randazzo, Bruno Pagano, Sara Iachettini, Pasquale Zizza, A. Stoppacciaro, M. Porru, Francesca Spinella, Salvati, E., Zizza, P., Rizzo, A., Iachettini, S., Cingolani, C., D'Angelo, C., Porru, M., Randazzo, Antonio, Pagano, Bruno, Novellino, Ettore, Pisanu, M. E., Stoppacciaro, A., Spinella, F., Bagnato, A., Gilson, E., Leonetti, C., and Biroccio, A.
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Tumor angiogenesis ,Endothelium ,Angiogenesis ,VEGF receptors ,Mice, Nude ,Neovascularization, Physiologic ,Animals ,Cell Line, Tumor ,Cells, Cultured ,Human Umbilical Vein Endothelial Cells ,Humans ,Ligands ,Mice ,Mice, Inbred C57BL ,Neoplasms ,Vascular Endothelial Growth Factor Receptor-2 ,G-Quadruplexes ,Neovascularization, Pathologic ,Promoter Regions, Genetic ,Genetics ,Biology ,Gene Regulation, Chromatin and Epigenetics ,G-quadruplex ,chemistry.chemical_compound ,medicine ,Kinase insert domain receptor ,Actin cytoskeleton ,Cell biology ,Vascular endothelial growth factor ,Endothelial stem cell ,Vascular endothelial growth factor A ,medicine.anatomical_structure ,chemistry ,Immunology ,Cancer cell ,Cancer research ,Nucleic acid ,biology.protein ,Corrigendum - Abstract
Tumor angiogenesis is mainly mediated by vascular endothelial growth factor (VEGF), a pro-angiogenic factor produced by cancer cells and active on the endothelium through the VEGF receptor 2 (VEGFR-2). Here we identify a G-rich sequence within the proximal promoter region of vegfr-2, able to form an antiparallel G-quadruplex (G4) structure. This G4 structure can be efficiently stabilized by small molecules with the consequent inhibition of vegfr-2 expression. Functionally, the G4-mediated reduction of VEGFR-2 protein causes a switching off of signaling components that, converging on actin cytoskeleton, regulate the cellular events leading to endothelial cell proliferation, migration and differentiation. As a result of endothelial cell function impairment, angiogenic process is strongly inhibited by G4 ligands both in vitro and in vivo. Interestingly, the G4-mediated antiangiogenic effect seems to recapitulate that observed by using a specific interference RNA against vegfr-2, and it is strongly antagonized by overexpressing the vegfr-2 gene. In conclusion, we describe the evidence for the existence of G4 in the promoter of vegfr-2, whose expression and function can be markedly inhibited by G4 ligands, thereby revealing a new, and so far undescribed, way to block VEGFR-2 as target for anticancer therapy.
- Published
- 2014
26. Evaluation of the microbiological and chemical aspects of autochthonous wild snails in Sardinia.
- Author
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Coroneo V, Marras L, Giaccone V, Conficoni D, Brignardello SAS, Bissacco E, Trapella C, Alogna A, Gentili V, Parisi A, Loi F, Cappai S, Pisanu M, and Cogoni MP
- Abstract
This study was conducted to acquire knowledge on the epidemiology and ecology of some zoonotic agents in snails. Chemical and microbiological analysis was carried out on 46 samples of snails belonging to the species of Helix aspersa and Helix (Eobania) vermiculata . The association between heavy metals and wild snails, a native consumer product in the Region of Sardinia, was determined. The molecular characterisation of Listeria monocytogenes virulence genes has shown a genetic profile that deserves more attention for the improvement of surveillance and risk prevention. Specimens of H. vermiculata showed higher concentrations of cadmium (M=0.80±0.56 mg/kg) than H. aspersa (M=0.61±0.17 mg /kg). A further objective was to determine whether the samples showed significant differences from the point of view of secretion characterisation, in terms of protein content, and to identify species-specific correlations and possible relationships with the environment. The presence of Salmonella enterica sub.sp houtenae (6,14: z4, z23) and Salmonella enterica subsp diarizonae (47: k: e, n, z15) (1 sample), Listeria monocytogenes (2 samples) with Molecular characterization of virulence genes together with the measurement of heavy metals in samples of wild snails has shown a health and hygiene profile that would deserve greater attention for the improvement of the surveillance and prevention of microbiological and chemical risk in such products which currently show a tendency towards increase in consumption., Competing Interests: Conflict of interest: The authors declare no potential conflict of interest., (©Copyright: the Author(s).)
- Published
- 2022
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27. Outbreak of acute hepatitis A associated with men who have sex with men (MSM) in North Sardinia 2017-2018.
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Bazzardi R, Dore E, Ciccozzi M, Lai A, Pisanu M, Babudieri S, and Maida I
- Subjects
- Adult, Coinfection, HIV Infections, Hepatitis A virus genetics, Hepatitis A virus isolation & purification, Homosexuality, Male, Hospitalization, Humans, Italy epidemiology, Male, Molecular Diagnostic Techniques, Phylogeny, RNA, Viral, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors, Serologic Tests, Disease Outbreaks, Hepatitis A epidemiology, Hepatitis A virus classification, Sexual and Gender Minorities
- Abstract
Introduction: We describe an outbreak of hepatitis A among men who have sex with men (MSM) which evolved in Sassari (Italy), between January 2017 and December 2018, close to a contextual of large concurrent hepatitis A outbreak reported in Europe and recently, in Italy., Methodology: HAV RNA detection and molecular characterization was performed from serum samples and/or stool by RT - PCR of VP1/2A junction region that ranges from nt. 2,873 to nt. 3,376. The phylogenetic correlation of the circulating hepatitis A strains was assessed by sequencing method according to the HAVNET protocol., Results: 10 Acute Hepatitis A virus (AHA)-positive cases, 8 of which were among men who have sex with men (MSM) were identified. All patients were tested at the time of hospitalization for the presence of anti-HIV antibodies, only two MSM resulted co-infected by HIV. No differences were observed in median age (37 years vs. 41 years, P-value = 0.14), severity or duration of hospitalization between seropositive and HIV-negative men. Phylogenetic analysis was conducted in 2 cases and revealed two distinct sequences of genotype IA linking to clusters recognized in MSM in other European countries in 2016., Conclusion: Our study reported a recent increase of notified hepatitis A cases attributable to cases in the European interconnectedness of MSM in Sassari, a small locality. Hepatitis A vaccination for MSM in Sardinia region is recommended; however, our data emphasize the need of hepatitis A screening and vaccination not only for MSM with occasional partners but also for those in monogamous relationships., Competing Interests: No Conflict of Interest is declared, (Copyright (c) 2020 Riccardo Bazzardi, Elena Dore, Massimo Ciccozzi, Alessia Lai, Margherita Pisanu, Sergio Babudieri, Ivana Maida.)
- Published
- 2020
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28. Evaluation of short purification cycles in naturally contaminated Mediterranean mussels (Mytilus galloprovincialis) harvested in Sardinia (Italy).
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Sferlazzo G, Meloni D, Lamon S, Marceddu M, Mureddu A, Consolati SG, Pisanu M, and Virgilio S
- Subjects
- Animals, Escherichia coli genetics, Escherichia coli isolation & purification, Food Microbiology, Hepatitis A virus genetics, Hepatitis A virus isolation & purification, Italy, Polymerase Chain Reaction methods, Salinity, Salmonella genetics, Salmonella isolation & purification, Temperature, Vibrio classification, Vibrio genetics, Vibrio isolation & purification, Virulence genetics, Food Contamination, Mytilus microbiology, Seafood microbiology, Shellfish microbiology
- Abstract
The aim of the present study was to investigate the effect of short purification cycles on the safety of naturally contaminated Mytilus galloprovincialis from harvesting areas of the Gulf of Olbia (Sardinia, Italy). Samples from ten batches of mussels were collected before, during and after purification treatment at two purification centres (A-B). All the samples were analysed for Escherichia coli and Salmonella spp according to Council Regulation (EC) 2285/2015. Detection and enumeration of Vibrio spp were performed according to previously published methods. Presumptive identification of Vibrio spp isolates were performed by means of conventional biochemical tests and polymerase chain reaction. The presence of Hepatitis A virus was detected by nested reverse transcriptase-polymerase chain reaction. Environmental parameters (water temperature and salinity) were also recorded. The results of Escherichia coli counts showed the overall efficacy of the short purification cycles; a purification cycle of 8 h led to a rapid decline in the concentration. The decrease in Escherichia coli counts does not correlate with the presence of naturally occurring vibrios, the decline of which occurs at an even slower rate. The average contamination levels for Vibrio spp before purification were 8.20 ± 0.47 and 7.99 ± 0.62 Log
10 CFU/g in samples collected at purification plants A and B, respectively. After purification, the average contamination levels were 8.10 ± 0.60 Log10 CFU/g at purification plant A and 7.85 ± 0.57 Log10 CFU/g at purification plant B. The contaminated samples revealed the presence of Vibrio alginolyticus (n=21), Vibrio fluvialis (n=12), Vibrio cholerae (n=4), Vibrio parahaemolyticus (n=2) and Vibrio vulnificus (n=1). The Vibrio parahaemolyticus isolates carried the tdh or the trh genes. None of the isolates was tdh+/trh+. Salmonella spp and Hepatitis A virus were not detected. The adoption of short purification cycles for Mytilus galloprovincialis in the presence of pathogenic vibrios might not be sufficient to guarantee the safety of consumers., (Copyright © 2018 Elsevier Ltd. All rights reserved.)- Published
- 2018
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29. The salivary proteome profile in patients affected by SAPHO syndrome characterized by a top-down RP-HPLC-ESI-MS platform.
- Author
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Sanna M, Firinu D, Manconi PE, Pisanu M, Murgia G, Piras V, Castagnola M, Messana I, del Giacco SR, and Cabras T
- Subjects
- Adult, Female, Humans, Middle Aged, Saliva chemistry, Statistics, Nonparametric, Acquired Hyperostosis Syndrome metabolism, Chromatography, High Pressure Liquid methods, Proteome analysis, Proteomics methods, Salivary Proteins and Peptides analysis, Spectrometry, Mass, Electrospray Ionization methods
- Abstract
SAPHO syndrome is a rare and often unrecognized disease with prominent inflammatory cutaneous and articular symptoms characterized by musculoskeletal manifestations (synovitis, hyperostosis, osteomyelitis) associated with dermatological conditions (severe acne and pustulosis). The acidic soluble fraction of whole saliva from 10 adult women affected by SAPHO syndrome and from a group of 28 healthy women was analysed by RP-HPLC-ESI-MS with the aim of discovering salivary biomarkers of the disorder. The levels of the oral proteins and peptides were correlated with clinical data. The following proteins showed a significant decreased concentration in saliva of SAPHO subjects with respect to controls: cystatin S1 and SN, histatins, the major acidic PRPs, P-C and P-B peptides. The cystatin SN abundance lowered according to the disease duration and histatins showed positive correlations with the C reactive protein. Statistical analysis performed excluding one patient with a different pattern of salivary proteins/peptides highlighted a positive relationship between cystatin S1, histatins 3, histatin 5, and the neutrophil count. Moreover, histatin 3 correlated positively with the total white cell count and negatively with the erythrocyte sedimentation rate. Levels and frequency of S100A12 protein showed a trend to increase in SAPHO patients. The high expression of this pro-inflammatory protein is probably related to the inflammatory response and to the altered neutrophil responses to functional stimuli that characterize SAPHO syndrome suggesting a possible application as a salivary biomarker.
- Published
- 2015
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30. Preliminary Study on Norovirus, Hepatitis A Virus, Escherichia coli and their Potential Seasonality in Shellfish from Different Growing and Harvesting Areas in Sardinia Region.
- Author
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Bazzardi R, Fattaccio MC, Salza S, Canu A, Marongiu E, and Pisanu M
- Abstract
Edible lamellibranch molluscs can be involved in foodborne disease and infections of varying severity. They are filter feeding animals able to retain and concentrate in their organism bacteria, parasites, viruses and biotoxins marine algae present in their external environment. Major shellfish harvesting and relaying areas from different areas in Sardinia region were defined and studied by analysing different physicochemical parameters in the water and the levels of Escherichia coli ( E. coli ), Norovirus (NoVs) genogroup I (NoVGI), NoVs genogroup II (NoVGII) and hepatitis A virus (HAV) in the shellfish harvested and farmed from 2009 to 2011. During that period the identification of the viral agents was carried out by one step real-time reverse transcriptase-polymerase chain reaction and Escherichia coli according to ISO TS 16649-3:2005 standard method. A total of 1266 shellfish samples were tested for NoVGI, NoVGII, HAV and faecal indicators. Norovirus contamination was found in 337 samples (26.6%); only one sample of mussels was positive for HAV (0.08%); while E. coli prevalence was 3.8% in shellfish. The probability of observing shellfish samples positive for NoVs, HAV and E. coli presence was associated with harvesting, growing and relaying areas, period of sampling, environmental parameters, animal species (P<0.05). Although the higher prevalence rate of human enteropathogenic viruses was found in the winter period, we did not observe a significant relationship between the effect of seawater temperature (seasonality) and NoVs presence all over the study period; in fact, according to statistical analysis, the presence of human enteric viruses does not appear to be related to water temperature., Competing Interests: the authors declare no potential conflict of interests.
- Published
- 2014
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- View/download PDF
31. Microbiological and Chemical Evaluation of Helix Spp. Snails from Local and Non-EU Markets, Utilised as Food in Sardinia.
- Author
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Corda A, Mara L, Virgilio S, Pisanu M, Chessa G, Parisi A, and Cogoni MP
- Abstract
With this study, 28 pools of snails of the genus Helix , respectively Helix aspersa (n=24) and Helix vermiculata (n=4) were analysed. They were taken from snail farming and stores. The snails were from Sardinia, other regions of Italy, and from abroad. All the samples were examined as pool looking for these microbiological target: Salmonella spp., Listeria monocytogenes , Escherichia coli O157, Clostridium perfringens , Norovirus and Hepatitis A Virus (HAV). In the same pools, the concentration of cadmium and lead by inductively coupled plasma mass spectrometry was also determined. The levels of these heavy metals were quite high, especially for cadmium. Two samples were positive for Salmonella spp., while no sample was positive for Escherichia coli O157, HAV and Norovirus. Two samples were positive for Clostridium perfringens and 8 for Listeria monocytogenes . The microrganisms related to Listeria monocytogenes were identified using biochemical techniques, then serotyped and gene sequenced by multiple loci sequence typing technique. Furthermore, antimicrobial restistence was tested on the same samples., Competing Interests: the authors declare no potential conflict of interests.
- Published
- 2014
- Full Text
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32. Genetic susceptibility to Candida infection: a new look at an old entity.
- Author
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Firinu D, Pisanu M, Piras B, Meleddu R, Lorrai MM, Manconi PE, and Del Giacco SR
- Subjects
- CARD Signaling Adaptor Proteins physiology, Humans, Interleukin-17 genetics, Mutation, STAT1 Transcription Factor genetics, Toll-Like Receptor 3 genetics, Candidiasis genetics, Genetic Predisposition to Disease
- Published
- 2013
33. An uncommon association of antiphospholipid syndrome, selective IgA deficiency and resistant-to-treatment relapsing polychondritis: efficacy of infliximab.
- Author
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Firinu D, Frau A, Pisanu M, Lorai MM, Meleddu R, Musu F, Manconi PE, and Del Giacco SR
- Subjects
- Female, Humans, Infliximab, Middle Aged, Antibodies, Monoclonal therapeutic use, Antiphospholipid Syndrome complications, IgA Deficiency complications, Polychondritis, Relapsing drug therapy, Tumor Necrosis Factor-alpha antagonists & inhibitors
- Abstract
Autoimmune complications in the context of primary immunodeficiency diseases represent a well-known phenomenon, and this is widely recognized also for Selective Immunoglobulin A deficiency (IgAD), the most common primary antibody deficiency (PAD). Relapsing polychondritis (RP) is a rare immune-mediated, difficult to treat, disorder in which the cartilaginous tissues are the target for inflammation and damage. Ocular inflammatory manifestations in RP are frequent and often sight-threatening. Antiphospholipid syndrome (APS) is an acquired prothrombotic state related to circulating autoantibodies against phospholipids and/or their cofactors. Rare reports of APS associated to RP, PAD and APS or PAD and RP are available.
- Published
- 2012
34. Prevalence of thermotolerant Campylobacter in broiler flocks and broiler carcasses in Italy.
- Author
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Di Giannatale E, Prencipe V, Colangeli P, Alessiani A, Barco L, Staffolani M, Tagliabue S, Grattarola C, Cerrone A, Costa A, Pisanu M, Santucci U, Iannitto G, and Migliorati G
- Subjects
- Abattoirs, Animals, Campylobacter physiology, Cecum microbiology, Hot Temperature, Italy, Campylobacter isolation & purification, Chickens microbiology
- Abstract
In accordance with European Union regulations, from 5 February until 15 December 2008, sampling and analysis activities were conducted in Italy to assess the extent of contamination caused by thermotolerant Campylobacter in broiler chickens farmed nationwide. The survey involved 48 poultry slaughterhouses distributed across eleven regions of Italy, where the caeca and carcasses of 393 slaughter batches were sampled. A total of 284 batches (72.3%) gave positive results for Campylobacter spp. as follows: 52.1% were contaminated by C. jejuni, 55.6% by C. coli and 1.1% by C. lari. C. jejuni and C. coli were isolated together in 37 batches (13% of positive results). Campylobacter spp. was isolated only from the caeca in 251 slaughter batches (63.9%) including caecal isolates of C. jejuni (48.2%), C. coli (50.6%), and C. lari (1.2%). Carcasses from 182 batches (46.3%) were contaminated by C. jejuni in 40.7% of cases, C. coli in 57.7% and the absence of C. lari from all batches examined. The contamination level observed in the carcasses ranged between 10 and 1.6 × 10(7) cfu/g.
- Published
- 2010
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