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481 results on '"Pircher, Hanspeter"'

1. Correction: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

Author

Kögl, Tamara, primary, Chang, Hsin-Fang, additional, Staniek, Julian, additional, Chiang, Samuel C.C., additional, Thoulass, Gudrun, additional, Lao, Jessica, additional, Weißert, Kristoffer, additional, Dettmer-Monaco, Viviane, additional, Geiger, Kerstin, additional, Manna, Paul T., additional, Beziat, Vivien, additional, Momenilandi, Mana, additional, Tu, Szu-Min, additional, Keppler, Selina J., additional, Pattu, Varsha, additional, Wolf, Philipp, additional, Kupferschmid, Laurence, additional, Tholen, Stefan, additional, Covill, Laura E., additional, Ebert, Karolina, additional, Straub, Tobias, additional, Groß, Miriam, additional, Gather, Ruth, additional, Engel, Helena, additional, Salzer, Ulrich, additional, Schell, Christoph, additional, Maier, Sarah, additional, Lehmberg, Kai, additional, Cornu, Tatjana I., additional, Pircher, Hanspeter, additional, Shahrooei, Mohammad, additional, Parvaneh, Nima, additional, Elling, Roland, additional, Rizzi, Marta, additional, Bryceson, Yenan T., additional, Ehl, Stephan, additional, Aichele, Peter, additional, and Ammann, Sandra, additional

Published
2024
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2. Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

Author

Kögl, Tamara, primary, Chang, Hsin-Fang, additional, Staniek, Julian, additional, Chiang, Samuel C.C., additional, Thoulass, Gudrun, additional, Lao, Jessica, additional, Weißert, Kristoffer, additional, Dettmer-Monaco, Viviane, additional, Geiger, Kerstin, additional, Manna, Paul T., additional, Beziat, Vivien, additional, Momenilandi, Mana, additional, Tu, Szu-Min, additional, Keppler, Selina J., additional, Pattu, Varsha, additional, Wolf, Philipp, additional, Kupferschmid, Laurence, additional, Tholen, Stefan, additional, Covill, Laura E., additional, Ebert, Karolina, additional, Straub, Tobias, additional, Groß, Miriam, additional, Gather, Ruth, additional, Engel, Helena, additional, Salzer, Ulrich, additional, Schell, Christoph, additional, Maier, Sarah, additional, Lehmberg, Kai, additional, Cornu, Tatjana I., additional, Pircher, Hanspeter, additional, Shahrooei, Mohammad, additional, Parvaneh, Nima, additional, Elling, Roland, additional, Rizzi, Marta, additional, Bryceson, Yenan T., additional, Ehl, Stephan, additional, Aichele, Peter, additional, and Ammann, Sandra, additional

Published
2024
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6. Supplementary Figure 10 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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7. Supplementary Figure 7 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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8. Supplementary Figure 8 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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9. Supplementary Figure 4 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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10. Supplementary References from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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11. Supplementary Figure 3 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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12. Supplementary Figure 9 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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13. Supplementary Figure 2 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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14. Supplementary Table 1 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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15. Supplementary Figure 5 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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16. Supplementary Table 2 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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17. Supplementary Figure 6 from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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18. Supplementary Materials and Methods from Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

Author

Wu, Richard C., primary, Liu, Shujuan, primary, Chacon, Jessica A., primary, Wu, Sheng, primary, Li, Yufeng, primary, Sukhumalchandra, Pariya, primary, Murray, James L., primary, Molldrem, Jeffrey J., primary, Hwu, Patrick, primary, Pircher, Hanspeter, primary, Lizée, Gregory, primary, and Radvanyi, Laszlo G., primary

Published
2023
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22. Supplementary Figures 1-10 from Tumor-Reactive CD8+ Early Effector T Cells Identified at Tumor Site in Primary and Metastatic Melanoma

Author

Anichini, Andrea, primary, Molla, Alessandra, primary, Vegetti, Claudia, primary, Bersani, Ilaria, primary, Zappasodi, Roberta, primary, Arienti, Flavio, primary, Ravagnani, Fernando, primary, Maurichi, Andrea, primary, Patuzzo, Roberto, primary, Santinami, Mario, primary, Pircher, Hanspeter, primary, Di Nicola, Massimo, primary, and Mortarini, Roberta, primary

Published
2023
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24. MHC I tetramer staining tends to overestimate the number of functionally relevant self‐reactive CD8 T cells in the preimmune repertoire.

Author

Pircher, Hanspeter, Pinschewer, Daniel D., and Boehm, Thomas

Subjects
T cell receptors, T cells, LYMPHOCYTIC choriomeningitis virus, CD8 antigen, VIRUS diseases
Abstract

Previous studies that used peptide‐MHC (pMHC) tetramers (tet) to identify self‐specific T cells have questioned the effectiveness of thymic‐negative selection. Here, we used pMHCI tet to enumerate CD8 T cells specific for the immunodominant gp33 epitope of lymphocytic choriomeningitis virus glycoprotein (GP) in mice transgenically engineered to express high levels of GP as a self‐antigen in the thymus. In GP‐transgenic mice (GP+), monoclonal P14 TCR+ CD8 T cells that express a GP‐specific TCR could not be detected by gp33/Db‐tet staining, indicative of their complete intrathymic deletion. By contrast, in the same GP+ mice, substantial numbers of polyclonal CD8 T cells identifiable by gp33/Db‐tet were present. The gp33‐tet staining profiles of polyclonal T cells from GP+ and GP‐negative (GP−) mice were overlapping, but mean fluorescence intensities were ∼15% lower in cells from GP+ mice. Remarkably, the gp33‐tet+ T cells in GP+ mice failed to clonally expand after lymphocytic choriomeningitis virus infection, whereas those of GP− mice did so. In Nur77GFP‐reporter mice, dose‐dependent responses to gp33 peptide‐induced TCR stimulation revealed that gp33‐tet+ T cells with high ligand sensitivity are lacking in GP+ mice. Hence, pMHCI tet staining identifies self‐specific CD8 T cells but tends to overestimate the number of truly self‐reactive cells. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors

Author

Sahin, Mehmet, primary, Remy, Melissa M., additional, Fallet, Benedict, additional, Sommerstein, Rami, additional, Florova, Marianna, additional, Langner, Anna, additional, Klausz, Katja, additional, Straub, Tobias, additional, Kreutzfeldt, Mario, additional, Wagner, Ingrid, additional, Schmidt, Cinzia T., additional, Malinge, Pauline, additional, Magistrelli, Giovanni, additional, Izui, Shozo, additional, Pircher, Hanspeter, additional, Verbeek, J. Sjef, additional, Merkler, Doron, additional, Peipp, Matthias, additional, and Pinschewer, Daniel D., additional

Published
2022
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31. ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

Author

Maul-Pavicic, Andrea, Chiang, Samuel C. C., Rensing-Ehl, Anne, Jessen, Birthe, Fauriat, Cyril, Wood, Stephanie M., Sjöqvist, Sebastian, Hufnagel, Markus, Schulze, Ilka, Bass, Thilo, Schamel, Wolfgang W., Fuchs, Sebastian, Pircher, Hanspeter, McCarl, Christie-Ann, Mikoshiba, Katsuhiko, Schwarz, Klaus, Feske, Stefan, Bryceson, Yenan T., Ehl, Stephan, and Yokoyama, Wayne M.

Published
2011

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